{"id":857,"date":"2019-02-21T09:20:16","date_gmt":"2019-02-21T01:20:16","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?page_id=857"},"modified":"2019-02-21T09:44:58","modified_gmt":"2019-02-21T01:44:58","slug":"platform-technology","status":"publish","type":"page","link":"http:\/\/www.puriactives.com\/en\/?page_id=857","title":{"rendered":"Platform Technology"},"content":{"rendered":"<div id=\"pl-857\"  class=\"panel-layout\" ><div id=\"pg-857-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-857-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-857-0-0-0\" class=\"so-panel widget widget_siteorigin-panels-postloop panel-first-child panel-last-child\" data-index=\"0\" >\n\n\t\t\n\t\t\n<article id=\"post-1292\" class=\"post-1292 post type-post status-publish format-standard hentry category-news\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1292\" title=\"Permalink to PURIACTIVES\u00ae PAD\" rel=\"bookmark\">PURIACTIVES\u00ae PAD<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1292\" title=\"18:53\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-06-23T18:53:57+08:00\">06\/23\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-06-23T18:53:57+08:00\">06\/23\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<p>PURIPHARM CO. LTD. &amp; PURIACTIVES\u00ae PLATFORM<\/p>\n<p>PuriPharm Co. Ltd. is a leading supplier of high-purity functional cosmetic actives, specializing in nano-encapsulation and advanced delivery systems for the global beauty industry.<\/p>\n<p>The PuriActives\u00ae platform represents a portfolio of science-backed, formulation-friendly active ingredients designed for modern skin and scalp care formulations.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-1ce3c6af1adcd9a708efe9940aa084bf~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-deb7e337780ec11eb906f87a4848480a&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"138\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-1ce3c6af1adcd9a708efe9940aa084bf~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-13625cce9ac8b0eb65054a567ceacf94&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-1ce3c6af1adcd9a708efe9940aa084bf~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-c7a85a88cd3a67c17825cb066bcd782e&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Each ingredient in the PuriActives\u00ae portfolio is selected and optimized for:<\/p>\n<ul>\n<li>Demonstrated efficacy through scientific literature and in-house validation<\/li>\n<li>Optimal formulation compatibility across a broad range of cosmetic product types<\/li>\n<li>Regulatory compliance for North American, European, and Asian markets<\/li>\n<li>Supply reliability and consistent batch-to-batch quality<\/li>\n<\/ul>\n<h2>PRODUCT SNAPSHOT<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-0dc0db6c35be04e1e54f86cc32508d47~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-055a6b89127c1b82172294f622117a37&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"919\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-0dc0db6c35be04e1e54f86cc32508d47~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-7c62ba122b3b5f0aa9eeea7d0505e7d9&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-6b638ac3ec84db56966eb25eec6055d0~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-e1f08130e6e575818da516e477e38c2b&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-f578e1c7b59b46e96f9f2408ece9943a~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-5a5e9ba986a109ab4f8509cabfd3334d&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"988\" data-rawheight=\"760\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-f578e1c7b59b46e96f9f2408ece9943a~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-b287154ec7d8647243ed5cbca3f3f39d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-3e7d262171dc871dad8104d355bdb6ad~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-2c592c95e2eb08f2804ea6037a620f99&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>WHY POTASSIUM AZELOYL DIGLYCINATE?<\/h2>\n<p>Azelaic acid is a well-recognized cosmetic ingredient with multiple skin benefits. However, its practical use in cosmetic formulations has been limited by poor water solubility, low pH requirements, and skin tolerability concerns.<\/p>\n<p>Potassium azeloyl diglycinate (PAD) was developed as a water-soluble derivative that retains the beneficial properties of azelaic acid while overcoming its formulation limitations.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-de68c2801c647cd33af53d6af6acdad1~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-41833eeeae4fc4f5d63d8da2026ca356&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"349\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-de68c2801c647cd33af53d6af6acdad1~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-c71ad039d8f78b1b041f5bcf7a667eb1&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-24ef9e297e143dc08403fb01f0bc900d~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-56e22fec1b5039a90acc07b962d5e0f6&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>FROM AZELAIC ACID TO A FORMULATION-FRIENDLY DERIVATIVE<\/h2>\n<p>Side-by-side comparison of key properties<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-f1ba0c6bd4ef167c8c3b789f61b63efe~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-6d8687eadd60654a81fd134c961fcb49&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"459\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-f1ba0c6bd4ef167c8c3b789f61b63efe~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-3de1ebc2159f77b7c8eac60e9d7affe6&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-eccde44bdc7675030cb3f7d1ae4600d0~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-86967d404c8f335aa52e921e7ffa5b2e&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>TECHNICAL PROFILE &amp; QUALITY SPECIFICATIONS<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-3184d0f35ef4980f4175b166ce559dfc~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-d51877f7e24f507026135847ffd60036&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"501\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-3184d0f35ef4980f4175b166ce559dfc~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-4309cf428ee2a3e90d1852f5813ffcd7&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-42e6a41174f830cf3911f952db89abbc~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-c914129afc3f3c04cb58953a10faa9af&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>MARKET NEED<\/h2>\n<p>Oily, Blemish-Prone, Uneven-Tone &amp; Sensitive Skin<\/p>\n<p>Global consumers increasingly seek multifunctional, gentle solutions for complex skin concerns. PuriActives\u00ae PAD addresses all of these needs in a single molecule.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-146c0ca423802e5235eada2938e4f361~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-2b1836f987bf04c687562ec0728e6f5d&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"423\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-146c0ca423802e5235eada2938e4f361~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-acaa1104869d6f54b4c7686cea772d9b&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-2d9abf0e1247d02bce446902a9d02eea~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-6a4652e9622a479ee40193f5a594584d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>MECHANISM OVERVIEW: MULTI-PATHWAY SKIN BALANCE<\/h2>\n<p>PuriActives\u00ae PAD works through five complementary pathways for comprehensive skin, scalp, and hair benefits:<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-2909aa2bd5ecd1541d26f3556843fab9~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-a67ab15aaf2c6b02fdf60a0f382b2d6d&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"458\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-2909aa2bd5ecd1541d26f3556843fab9~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-61497b63400be4121b0e4357bbbdcfed&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-26f5196ed93c22240db038b3beb29f02~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215415&amp;auth_key=1782215415-0-0-9755acb83614b05cffcd3323940b0994&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Brightening Mechanism: Tyrosinase \/ Melanin Pathway<\/p>\n<p>Tyrosinase \u2014 The Rate-Limiting Enzyme<\/p>\n<p>Tyrosinase catalyzes the conversion of tyrosine to melanin pigments in melanocytes. It is the key regulatory enzyme in melanin synthesis, making it a primary target for skin-brightening actives.<\/p>\n<p>PAD Mechanism of Action<\/p>\n<p>PuriActives\u00ae PAD has been reported to inhibit tyrosinase activity, helping to reduce melanin production and supporting a brighter, more even-looking skin tone.<\/p>\n<p>Key Pathway Cascade<\/p>\n<p>PAD \u2192 Tyrosinase Inhibition \u2192 Reduced Melanin Synthesis \u2192 Brighter Skin Appearance<\/p>\n<p>Clinical Relevance<\/p>\n<p>Tyrosinase inhibitors are widely used in cosmetic brightening products. PAD offers a water-soluble, well-tolerated alternative for formulators seeking brightening efficacy without the formulation challenges of azelaic acid.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-930b03a356ac1141c026005e9c1c704b~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-98928f603f073ca344ba56d14a535917&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"752\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-930b03a356ac1141c026005e9c1c704b~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-c1470ce488957b3d66f7f514d5882483&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-f75cfd0995cb757de9b6dfa8a5b0c26c~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215415&amp;auth_key=1782215415-0-0-9c5fef5775ebb839aeb934c6f8671b08&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Uneven Tone and Dark Spot Care<\/p>\n<p>Dark spots and uneven skin tone result from localized melanin overproduction, often triggered by UV exposure, hormonal changes, or post-inflammatory responses. PuriActives\u00ae PAD helps address this through its tyrosinase-inhibition-related activity, supporting a more uniform-looking complexion over continued use.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-0c769aa5c5019371e63db637932b1105~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-7b75760e069da5f6a72308b1ea7d4f69&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"382\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-0c769aa5c5019371e63db637932b1105~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-bf5feda87cd7788c6647fc28b038f5da&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-c4d80842f9533a80df04d09a5f1d6644~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-50b94a4584802a4fa32da938b28479cd&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Sebum Balance Mechanism<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-448be5ec9b6363199a4726049151a94e~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-625b192f0504709da55665ed2d71268e&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"470\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-448be5ec9b6363199a4726049151a94e~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-681080bc8928c61c73626564f4a0ebef&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-a0c8b41c522188d357d591ddc02bfbb1~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-7bb60080c666c80c2738bdc3abd611ab&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Blemish-Prone Skin Care Positioning<\/p>\n<p>Excess sebum, inflammation, and blemish formation are interconnected concerns. PuriActives\u00ae PAD&#8217;s dual action \u2014 sebum balance support plus anti-inflammatory properties \u2014 makes it well-suited for blemish-prone skin care formulations.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-e4bd83da4ac3aad5d39e6be19dff20f1~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-941caeb63086dd12ae3bca374dde46fe&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"375\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-e4bd83da4ac3aad5d39e6be19dff20f1~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-3bd335b8e7815f08f2040fc91efabe42&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-0d4ab572751d78ae1fefc9551fb9df26~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-d8d46ce425be6b964557261f2d0fa0c5&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Redness-Prone and Sensitive-Skin Comfort<\/p>\n<p>Redness-prone skin is often associated with elevated inflammatory mediators, including IL-1\u03b1 (interleukin-1 alpha), a key pro-inflammatory cytokine. PuriActives\u00ae PAD has been reported to help reduce IL-1\u03b1 release, providing anti-inflammatory support that soothes the appearance of redness. Combined with glycine&#8217;s skin-conditioning properties and a neutral pH of 6.5\u20137.5, PAD offers excellent tolerance for sensitive skin.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-fbd951b1cdbf122464d8e8e79bb5ea25~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-279b1a8934c301e943fe4cf45e3ebbfc&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"377\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-fbd951b1cdbf122464d8e8e79bb5ea25~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-2949b290015db9da364845221fe4dca8&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-925420507b4822cffa55712b38972907~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-d723ec735902f8cbf675135f71ce7366&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Hydration and Elasticity Support<\/p>\n<p>The glycine moiety in PuriActives\u00ae PAD contributes humectant and skin-conditioning properties. Glycine is a naturally occurring amino acid that helps support skin moisture retention, elasticity, and suppleness \u2014 complementing brightening and sebum-balancing benefits to create a well-rounded multifunctional active.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-ac8bda966870ddc41c599061da8f6ca6~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-330195564f36e1db8de08b658167e7a3&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"419\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-ac8bda966870ddc41c599061da8f6ca6~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-ee02be26d093a0c89609d23ac9e6e77e&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-bfd10e27972a180cd387f9e64e72a495~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-29665ae0192fb2a99e12dd5e6a1fa3df&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Scalp Care Opportunity<\/p>\n<p>Scalp health is increasingly recognized as the foundation of healthy-looking hair. Oily scalp, discomfort, and imbalance are common concerns. PuriActives\u00ae PAD&#8217;s sebum-regulating and anti-inflammatory properties translate effectively to scalp care, offering brands a science-backed active for this emerging category.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-e10b39f3a8cc82b44e7b984428588420~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-17c863a79590668c7ad651fc2720c43b&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"423\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-e10b39f3a8cc82b44e7b984428588420~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-8ca71495207ec443b7d33d929b8832bf&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-2c2831e64ead8e35aa07d80f53b40f90~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-db86d2a41f70ccf9f70a6d66d843dacb&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Hair-Care Mechanism: 5\u03b1-Reductase \/ IL-1\u03b1 \/ Scalp Balance<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-d24b66efd8cbcc4f2f2b713ebba75232~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-c36a6b50fca27b45f9a11b7961e68c2d&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"475\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-d24b66efd8cbcc4f2f2b713ebba75232~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-f45e7c8c34437e6812505f7c93be4186&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-8544148ceee8fd158e585f6d6b6739c9~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215415&amp;auth_key=1782215415-0-0-cb0907756e20f24b13489c19a9ea422a&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Hair Fiber Care Patent Story<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-9b080e8e562ce4884f3f14d5a165bcac~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-a724a17d6598ac49441d2fa9fcfc9167&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"445\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-9b080e8e562ce4884f3f14d5a165bcac~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-da072864766ce1da9545aa3a5d0a0222&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-c2c93654b1ed51e43c7049d557c8c7c0~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-84c181b2bdc122acc4d15840d2962d31&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Formulation Advantages<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-e322a1f051e4fe86464286d38675370b~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-2b6fc713c2f7c5549b8db6c9abcbbdc2&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"533\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-e322a1f051e4fe86464286d38675370b~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215415&amp;auth_key=1782215415-0-0-385dc2cac39094dbc53bf0898d52f24d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-a36e15577285db9c1696470c7d6a7f37~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215415&amp;auth_key=1782215415-0-0-88ba3d33521ab22a784d1338aa65510d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Recommended Use Level &amp; Formulation Formats<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-45a8610ea3f740c2760af1c7645a01f3~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-11fab7953132aae067f46d7905275ab2&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"523\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-45a8610ea3f740c2760af1c7645a01f3~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-782a215c040040f792d421d6e3665d1f&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-58ec56f6fee4707cb1d5943c5f4047be~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-845f253749624795b5c4b2e136a71fcb&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Application Concepts<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-9204050279c61be8c0b09c8e582b5f3a~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-9f567e0bd5f63545c37248ad90f84cbf&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"493\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-9204050279c61be8c0b09c8e582b5f3a~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-15f8610003b0ea2976fd32ba7f7d781d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-c9cdb7d560311126abb36f67924ed6d1~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-d3845710f07d3db2978c372a522e7479&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Claim Language &amp; Regulatory-Friendly Wording<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-009a3a334206e0a1c3c0614f1f8ca9ea~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-ba226c472c123c879ac3390f317f9ba5&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"382\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-009a3a334206e0a1c3c0614f1f8ca9ea~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-1adba047a02fa803d798773c6f5c9450&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-58748a358aa1d30ce78b62ba12dee1a5~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-08a86bdb3924f6ecd2450e6cfba6c9d5&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Competitive Value Proposition<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-7b56e7dcc898a847e65e13f1a45413d2~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-4796d33e1c076a8bc1925965591bc81b&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"511\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-7b56e7dcc898a847e65e13f1a45413d2~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-1d981cf7e4fe616dc851b18bb38872e2&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-f30daed84caf14167f1d0c7ca4a07515~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-08e639b075d5fd73e61ae2c008d2077d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Summary: One Molecule, Skin + Scalp + Hair Balance<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-a96244b48a94c413ed7ec5a034aedda6~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1782212091-0-0-42ca44ba6f177f645006c068473ece60&amp;bizSceneCode=article_draft&amp;expiration=1782212091&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"404\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-a96244b48a94c413ed7ec5a034aedda6~resize:0:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-d597f89527415b9538914d4eecd00ddc&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2052825789847041943\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-f5b130dd6e26926a9eca676ed4eac0b8~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1782215414&amp;auth_key=1782215414-0-0-e80b73c6742612d0d34efc0a04d9ae75&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1292 -->\n\n\t\n\t\t\n<article id=\"post-1289\" class=\"post-1289 post type-post status-publish format-standard hentry category-news tag-nano-liposomal-haematococcus-astaxanthin-anti-oxidation tag-smoothness\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1289\" title=\"Permalink to PuriActives\u00ae PALMITOYL METHOXYTRYPTAMINE\" rel=\"bookmark\">PuriActives\u00ae PALMITOYL METHOXYTRYPTAMINE<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1289\" title=\"20:25\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-06-16T20:25:35+08:00\">06\/16\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-06-16T20:25:35+08:00\">06\/16\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<p>Available in Pure Crystalline Powder &amp; NanoActive\u00ae Water-Soluble Liquid Grades<\/p>\n<h2>1. PRODUCT IDENTIFICATION<\/h2>\n<ul>\n<li>Trade Name: PuriActives\u00ae PALMITOYL METHOXYTRYPTAMINE (Pure Powder Grade) \/ NanoActive\u00ae PALMITOYL METHOXYTRYPTAMINE (Water-Soluble Liquid Grade)<\/li>\n<li>INCI Name (US\/EU):<\/li>\n<\/ul>\n<p>Pure Powder Grade: Palmitoyl Methoxytryptamine<\/p>\n<p>NanoActive\u00ae Grade: Water, Glycerin, Phospholipids, Palmitoyl Methoxytryptamine, Caprylic\/Capric Glyceride<\/p>\n<ul>\n<li>Chemical Name (Active): N-[2-(5-methoxy-1H-indol-3-yl)ethyl]hexadecanamide<\/li>\n<li>CAS Number (Active): 224422-91-3<\/li>\n<li>Molecular Formula (Active): C\u2082\u2087H\u2084\u2084N\u2082O\u2082<\/li>\n<li>Molecular Weight (Active): 428.66 g\/mol<\/li>\n<li>Chemical Structure: CH\u2083-(CH\u2082)\u2081\u2084-CO-NH-CH\u2082-CH\u2082-C\u2088H\u2084(OCH\u2083)NH<\/li>\n<\/ul>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-516db06c074bc178bb0326a88fd8343a~resize:1440:q75.jpg?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781612511-0-0-cece333fe791ebb21ab0fd5f6ddfe7b0&amp;bizSceneCode=article_draft&amp;expiration=1781612511&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"720\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-516db06c074bc178bb0326a88fd8343a~resize:0:q75.jpg?source=1f5c5e47&amp;expiration=1781615672&amp;auth_key=1781615672-0-0-28ceab0cdd9a69b9d1e651bff9df2c0d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2050310319852074545\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-5be8b6cf81b9c54662514e9b142d206e~resize:1440:q75.jpg?source=1f5c5e47&amp;expiration=1781615673&amp;auth_key=1781615673-0-0-381d7e8b22e475880c2913e6576fea64&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>2. PRODUCT DESCRIPTION<\/h2>\n<p>PuriActives\u00ae Palmitoyl Methoxytryptamine is a high-purity, bio-mimetic lipid-alkaloid conjugate engineered to deliver profound neuro-cosmetic soothing and cellular anti-inflammatory benefits. By coupling the potent neuro-active molecule 5-methoxytryptamine (a direct analog and precursor of melatonin) with palmitic acid, this compound exhibits exceptional skin-penetration kinetics and lipid-membrane affinity.<\/p>\n<p>To address the inherent solubility limitations of the pure lipophilic crystalline powder in water-based cosmetic architectures, PuriPharm offers NanoActive\u00ae Palmitoyl Methoxytryptamine. Utilizing state-of-the-art advanced nano-delivery technology, this grade encapsulates the active within a biomimetic phospholipid bilayer membrane (average particle size &lt; 100 nm). This advanced delivery system transforms a highly lipophilic compound into a thermodynamic-stable, optically transparent, and water-dispersible active, dramatically boosting skin bioavailability and offering effortless formulation flexibility.<\/p>\n<h2>3. CORE MECHANISMS OF ACTION<\/h2>\n<h2>A. Neurogenic Soothing via TRP Channel Modulation<\/h2>\n<p>Sensitive skin is characterized by hyper-excited sensory nerve endings. Palmitoyl Methoxytryptamine acts as a gentle, soothing modulator of neurogenic pathways. It targets transient receptor potential (TRP) channels, specifically mitigating the over-activation of TRPV1 (capsaicin receptor), which in turn suppresses sensations of burning, stinging, tightness, and itching.<\/p>\n<h2>B. Anti-Inflammaging &amp; PPAR-\u03b1 Activation<\/h2>\n<p>Similar to endogenous endocannabinoid-like molecules (such as Palmitoylethanolamide \/ PEA), Palmitoyl Methoxytryptamine serves as an agonist for the nuclear receptor PPAR-\u03b1 (Peroxisome Proliferator-Activated Receptor Alpha). This activation triggers downstream anti-inflammatory cascades:<\/p>\n<ul>\n<li>Inhibits the release of pro-inflammatory cytokines such as IL-1\u03b2, IL-6, and TNF-\u03b1.<\/li>\n<li>Suppresses mast cell degranulation, mitigating sudden skin redness and histamine-induced itchiness.<\/li>\n<\/ul>\n<h2>C. Melatonin Receptor Agonism &amp; Circadian Repair<\/h2>\n<p>Because 5-methoxytryptamine is a direct deacetylation analog of melatonin (N-acetyl-5-methoxytryptamine), Palmitoyl Methoxytryptamine acts as a highly potent biomimetic agent for cutaneous melatonin receptors (MT1 and MT2). This direct agonism:<\/p>\n<ul>\n<li>Resets and synchronizes the skin&#8217;s biological clock genes (such as CLOCK and PER1).<\/li>\n<li>Enhances the skin\u2019s endogenous defense against oxidative stress induced by ultraviolet (UV) radiation and blue light.<\/li>\n<li>Accelerates nocturnal DNA repair and cell regeneration, restoring a radiant and rested complexion overnight.<\/li>\n<\/ul>\n<h2>D. Enhanced Bioavailability via Lipophilic Vectoring &amp; Nano-Carrier Delivery<\/h2>\n<ul>\n<li>Pure Powder: Conjugation with palmitic acid increases the partition coefficient (log P \u2248 7.15), allowing the active to integrate seamlessly into the intercellular lipid matrix of the stratum corneum.<\/li>\n<li>NanoActive\u00ae Liquid: The phospholipid membrane of the nano-carriers fuses directly with the lipid bilayers of the stratum corneum. This bypasses the rate-limiting barrier of intercellular lipid transport, creating a &#8220;depot effect&#8221; in the viable epidermis and accelerating cellular uptake of the active molecule.<\/li>\n<\/ul>\n<h2>4. TECHNICAL SPECIFICATIONS<\/h2>\n<h2>[Grade A] PuriActives\u00ae PALMITOYL METHOXYTRYPTAMINE (Pure Powder)<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-f49e60814fd53905e4264e7e31478ff0~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781612511-0-0-57b38a49a3a8bc3f85f3d14581dce19c&amp;bizSceneCode=article_draft&amp;expiration=1781612511&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"521\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-f49e60814fd53905e4264e7e31478ff0~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781615672&amp;auth_key=1781615672-0-0-8fa78a31056eff4d272e60ffe7e86db0&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2050310319852074545\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-b404e096c61ace9990570bbe0407ab95~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781615673&amp;auth_key=1781615673-0-0-7260f0bea0891d29289f375e800038ad&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>[Grade B] NanoActive\u00ae PALMITOYL METHOXYTRYPTAMINE (Water-Soluble Liquid)<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-379ad8e9ddf122f37cade8c9cfb4ae62~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781612511-0-0-1d75f59e66fc359ee70c4cb2ecb822c8&amp;bizSceneCode=article_draft&amp;expiration=1781612511&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"568\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-379ad8e9ddf122f37cade8c9cfb4ae62~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781615672&amp;auth_key=1781615672-0-0-299315a2b2159e29784b6d36679b8506&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2050310319852074545\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-fa5f6aefb3531bd06c5b8c30c752e255~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781615673&amp;auth_key=1781615673-0-0-d966ebf3a8ff1b11c83edf70ffbdefa8&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Microbiological Specifications (Both Grades)<\/h2>\n<ul>\n<li>Total Aerobic Plate Count: \u2264 100 CFU\/g<\/li>\n<li>Yeasts and Molds: \u2264 10 CFU\/g<\/li>\n<li>Pathogens (E. coli, S. aureus, P. aeruginosa): Negative\/g<\/li>\n<\/ul>\n<h2>5. COSMETIC BENEFITS &amp; CLINICAL CLAIMS<\/h2>\n<ul>\n<li>Instant Neuro-Soothing: Rapidly reduces sensory discomfort, itching, and neuro-sensitivity.<\/li>\n<li>Anti-Redness &amp; Erythema Control: Dampens micro-vascular reactivity and controls flushing in rosacea-prone skin.<\/li>\n<li>Skin Barrier Recovery: Accelerates epidermal barrier repair and decreases trans-epidermal water loss (TEWL).<\/li>\n<li>Intense Inflammaging Defense: Protects structural proteins (collagen and elastin) from enzymatic degradation caused by chronic low-grade inflammation.<\/li>\n<li>Chronobiological Renewal: Aids in resetting skin repair rhythms, restoring a radiant and rested complexion overnight.<\/li>\n<\/ul>\n<h2>6. FORMULATION &amp; PROCESSING GUIDELINES (PURE POWDER)<\/h2>\n<h2>A. Recommended Usage Levels<\/h2>\n<ul>\n<li>Daily Soothing &amp; Maintenance Creams: 0.05% &#8211; 0.2%<\/li>\n<li>Intensive SOS \/ Post-Procedure Care: 0.2% &#8211; 0.5%<\/li>\n<\/ul>\n<h2>B. Solubility &amp; Incorporation<\/h2>\n<ul>\n<li>Oil Phase: Soluble in hot cosmetic esters and lipids (e.g., Caprylic\/Capric Triglyceride, Squalane, C12-15 Alkyl Benzoate) at 75\u00b0C &#8211; 80\u00b0C.<\/li>\n<li>Water Phase: Insoluble in water.<\/li>\n<\/ul>\n<h2>C. Processing Temperature<\/h2>\n<p>\u25cf Stable at temperatures up to 85\u00b0C. It is recommended to dissolve the active in the oil phase before emulsification.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-242e9056d1253c02ce038358c3a6f606~resize:1440:q75.jpg?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781612511-0-0-d9d81d018b550d0e78f117a3ee8c9344&amp;bizSceneCode=article_draft&amp;expiration=1781612511&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"720\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-242e9056d1253c02ce038358c3a6f606~resize:0:q75.jpg?source=1f5c5e47&amp;expiration=1781615672&amp;auth_key=1781615672-0-0-cffc979721b0bad1425f7e340a9cd308&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-be6753be699b5b124ab6cc6907ede1dc~resize:1440:q75.jpg?source=1f5c5e47&amp;expiration=1781615673&amp;auth_key=1781615673-0-0-271f735939acd7fb24ba22ce4ba14394&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>7. FORMULATION &amp; PROCESSING GUIDELINES (NANOACTIVE\u00ae LIQUID)<\/h2>\n<h2>A. Recommended Usage Levels<\/h2>\n<ul>\n<li>Daily Soothing Serums &amp; Toners: 1.0% &#8211; 4.0% (Equivalent to 0.05% &#8211; 0.2% pure active)<\/li>\n<li>High-Concentration Clinical Soothing Ampoules: 4.0% &#8211; 10.0% (Equivalent to 0.2% &#8211; 0.5% pure active)<\/li>\n<\/ul>\n<h2>B. Solubility &amp; Incorporation<\/h2>\n<ul>\n<li>Water Phase: 100% dispersible in water. It yields an elegant, optically transparent solution, ideal for clear gel, serum, toner, and essence formulations.<\/li>\n<li>Incorporation: Highly recommended to add to the water phase or post-emulsification phase during the cooling stage at temperatures below 40\u00b0C.<\/li>\n<\/ul>\n<h2>C. Processing Guidelines &amp; Shear Sensitivity<\/h2>\n<p>\u25cf Avoid exposing NanoActive\u00ae grade to high-shear homogenization equipment (e.g., rotor-stator homogenizers) for prolonged periods, as extreme shear can disrupt the lipid vesicle bilayers. Use paddle stirring or gentle marine propellers to disperse.<\/p>\n<h2>D. pH Stability (NanoActive\u00ae)<\/h2>\n<p>\u25cf Optimum stability is observed within a pH range of 4.5 &#8211; 6.5.<\/p>\n<h2>8. STORAGE, SHELF LIFE &amp; REGULATORY<\/h2>\n<p>\u25cf Storage Conditions: Store in the original, tightly sealed container.<\/p>\n<ul>\n<li>Pure Powder: Keep in a cool, dry, and well-ventilated area, preferably refrigerated at 2\u00b0C &#8211; 8\u00b0C for long-term storage.<\/li>\n<li>NanoActive\u00ae Liquid: Do not freeze. Store at 4\u00b0C &#8211; 25\u00b0C, protected from direct sunlight and heat.<\/li>\n<\/ul>\n<p>\u25cf Shelf Life: 24 months from the date of manufacture when stored under prescribed conditions.<\/p>\n<p>\u25cf Regulatory Compliance: Approved for use in cosmetics worldwide (including EU, USA, and China IECIC listing). Vegan-compliant, cruelty-free, and non-GMO.<\/p>\n<p>Disclaimer: The information contained in this document is provided in good faith and is based on our current technical knowledge. Formulation results may vary depending on other raw materials and processing equipment used. It is the formulator&#8217;s responsibility to conduct final product safety and efficacy tests.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-5feab926b0ff39c1d79e2f8c483a9704~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781612511-0-0-4d0141f3cac28cd9b275301e2b5271d0&amp;bizSceneCode=article_draft&amp;expiration=1781612511&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-5feab926b0ff39c1d79e2f8c483a9704~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781615673&amp;auth_key=1781615673-0-0-99d9f55cfdfff6906fc4894c3a7c5bbb&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2050310319852074545\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-762f7acd7270aa98a1f07d16c7e79284~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781615673&amp;auth_key=1781615673-0-0-fe33447ba541fe4055858649e20485f5&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1289 -->\n\n\t\n\t\t\n<article id=\"post-1285\" class=\"post-1285 post type-post status-publish format-standard hentry category-news tag-anti-dandruff tag-anti-dermatitis tag-anti-free-radicals\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1285\" title=\"Permalink to NANOACTIVE ENOXOLONE PuriActives Core Molecule x NanoActive Delivery\" rel=\"bookmark\">NANOACTIVE ENOXOLONE PuriActives Core Molecule x NanoActive Delivery<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1285\" title=\"23:58\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-06-15T23:58:52+08:00\">06\/15\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-06-15T23:58:52+08:00\">06\/15\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<h2>PuriPharm: Dual Pillars of Innovation<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-d6bc87e7424a43dfc7be9e39aef9d3c1~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-43e023dc5c6aa33ae7a2ab957903b455&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"376\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-d6bc87e7424a43dfc7be9e39aef9d3c1~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542338&amp;auth_key=1781542338-0-0-bc88c08807fa9b8c0f57421eaf617ac0&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-4c920061a4e86ab92250bb9e55a98c7d~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-b4db1249efc22386d9e70ff9aca90132&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Two Core Innovation Pillars<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-ff9b839b3e5b1b3650a4e738591f9bad~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-0b1b3bc174b9bf2b8f2d39ba0bc6f3cb&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"410\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-ff9b839b3e5b1b3650a4e738591f9bad~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542338&amp;auth_key=1781542338-0-0-ccca003343150f2a3859ab3ad10f8439&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-019bf53fcdc2891713ae52c74bd1d7d7~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-7c4fd6c57a1e4791ea3eee83bd2c2ff7&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>PuriActives: Enoxolone from Licorice Root<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-fcbdc2334b2a4dd0de53be52895dd866~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-98ed5bb5426e1adb0e09888c6f0b95a6&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"498\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-fcbdc2334b2a4dd0de53be52895dd866~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-7dee5b46924788d9e777af3c9e322390&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-00e2644cf2e7ef5f0ada8b766916e17c~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-1b9207d0fafa88adebbdd4056097aeb9&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>NanoActive NanoCarrier: Delivery Architecture<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-39b4777f4c33693167bc7a844f63ca14~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-1dfcc9e8e9d4fbc9dffd39018d8dc58a&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"458\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-39b4777f4c33693167bc7a844f63ca14~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-a7af8cfb92b5a040ba46814fa408823d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-645f5ff707af63e30ab525c04c392c78~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-ba6bcb062297600d0da95f2550ba6834&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Application Challenges: Enoxolone Limitations<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-8ebbcf59b6b736c3db8afffe0345bb08~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-042351143689bb39ee76174f500b6382&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"448\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-8ebbcf59b6b736c3db8afffe0345bb08~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-765f37021f53ee2b8cdccf7c4133765c&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-7406835f58fb899af6150b7668b06ed1~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-0c6055b49671cd9081e970cbaf5cccce&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>NanoActive System Solution<\/h2>\n<p>NanoActive Enoxolone = PuriActives Molecule + NanoActive Technology<\/p>\n<p>Through nano-encapsulation, insoluble crystalline powder becomes a clear, transparent, stable bioactive liquid. We deliver precision-calculated efficacy.<\/p>\n<h2>NanoActive Parameters: Size Advantage<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-f8984840a4b56e5b73dafbecb24d83c2~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-e96b55250d135c1f5b7516ede703e1ab&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"610\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-f8984840a4b56e5b73dafbecb24d83c2~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542338&amp;auth_key=1781542338-0-0-594d02059117bc6e505a3e0432735284&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-10d6154664dfc75319d1cc36cb64f484~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-6df4276e940ad201eb786c434636fdeb&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Product Technical Specifications<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-a2d0268f024ed2ebdbf503a246e35702~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-03e457f0dd2455b7a502d77572e3fa9a&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"500\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-a2d0268f024ed2ebdbf503a246e35702~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542338&amp;auth_key=1781542338-0-0-cedbf3c1c59f655c4b1ca517d86ed57e&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-c7e0dbfbb3fad0be70bb9468fe41bd42~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-7d160f9688f427796f1bf0e6ac3e4e40&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>NanoActive Drives Deep Penetration<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-09fa43ebb379af86d3fa2524e70df737~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-8e4b8f9dd723c09336e47b5979686c4c&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"689\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-09fa43ebb379af86d3fa2524e70df737~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542338&amp;auth_key=1781542338-0-0-89149f14a0ca32666d9dca95145c4185&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-3b4554218852d8eba51587121dec3dab~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-89668a0518c2130f1ec3fa0bc25aa7dc&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-fb3acc060383b3aba657061641679258~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-f3120858463aadcc26ed7f1ff89b0e84&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"1215\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-fb3acc060383b3aba657061641679258~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-015792670d57b7f7b53a8082a5c83573&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2050002735462982656\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-97a045d1ed97816594dcb31d4ee309a0~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-40242602e1c0e865a9c773f7fc477fe8&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Multi-dimensional Efficacy<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-35453cef291d9371b2fd6183c980a9e1~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-9e8f774ab7d5307d1aa2e411b648b28e&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"502\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-35453cef291d9371b2fd6183c980a9e1~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542338&amp;auth_key=1781542338-0-0-1e00658c8c60c1272aedd0526210a515&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-2633eb4756b593d378bbe4ac98a3c47d~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-7f4159d4fb3e7f722b6e371c181bfa4c&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Anti-inflammatory Power: TSLP Inhibition<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-0bff3d1ea1e7989454d2566e4c7fb9d0~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-c8bf704b87a2d34c4afb3ab833e1596c&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"435\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-0bff3d1ea1e7989454d2566e4c7fb9d0~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-3de54416ac8beb85c7004ca1656f2d29&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-8423a68ac6253dceab5aa0a2180118cd~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-d0bdacffa0268bef7c70d95b9cc66093&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Clinical Evidence: Atopic Dermatitis Relief<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-8d5126b8a0f2017c26085b4afc3091ea~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-e8427cfb643317278ccae021ccf08cc0&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"341\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-8d5126b8a0f2017c26085b4afc3091ea~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542338&amp;auth_key=1781542338-0-0-d2a6c88bed876d3f33c411be670d95fa&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-f30d5667d6c0e74f1772498e665bf79c~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-d76c3e22b082a4f6894421e7b1bc8d9b&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>NanoActive Antioxidant Defense Matrix<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-8ebd1c998921259b20abfeb93a884fca~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-76a62a31f54da1322a5c5bd093344249&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"402\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-8ebd1c998921259b20abfeb93a884fca~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-71f15701bb08ff03c484f80c276459ab&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-c931ff1b678ca691f6a66fc8c90ef808~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-35f16defc3e4edc8b878bdc7d29df165&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>11\u03b2-HSD1 Inhibition: Correcting Steroid Skin<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-75b9c2718463d831d0a988deddc4cf8c~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-2474115516357ccbf700044beb9b0f3b&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"998\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-75b9c2718463d831d0a988deddc4cf8c~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542338&amp;auth_key=1781542338-0-0-ca363d4e49d47306bd5d749cc29b3460&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-594b066f5cd15e77cf36c01e77e3826c~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-e266e6d21e957602dbef63abd014e3a2&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-d64ae993369f0ea2b7e09b83f0129229~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-370e99e073fe64864878667088d2a8c5&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"1023\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-d64ae993369f0ea2b7e09b83f0129229~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-b0313c431659b668e7f189e013692c17&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2050002735462982656\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-bfc80cf82ac1a6a4f6f07d4b44322550~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542340&amp;auth_key=1781542340-0-0-33af064109f8676b193a1b3db4a3984e&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Antimicrobial Activity<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-65e047cadc2e204275d31e2d12dd3a1f~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-8da42aa99dea1f31917ea4fa893cfed4&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"551\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-65e047cadc2e204275d31e2d12dd3a1f~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-b19e7b62b84ae3e77aa780fa2366902f&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-d3d3a86f7b0ec4b0f42d95cc7431174d~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-c7fd7cf7d0e2e742d7a85170d7156cf3&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Skin Barrier Repair &amp; Soothing<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-edef4bda974d6ad76ff016b65113147f~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-b088ad8824700e831aa62e2f05d72a30&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"472\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-edef4bda974d6ad76ff016b65113147f~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-4ba7387acfbc4fc42691943b95b5d84f&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2050002735462982656\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-b2806df73a57b5c5ecceec5f9e3bb5af~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-1db1a2489673be20ec4dc5d1d8355557&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>Formulation Application Guide<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-5a3c8515049d9de1c508feee58b5ecce~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781539182-0-0-814dbcde75a922f1e7660a66cd3c55c2&amp;bizSceneCode=article_draft&amp;expiration=1781539182&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"459\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-5a3c8515049d9de1c508feee58b5ecce~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781542338&amp;auth_key=1781542338-0-0-b29d50abce8525147f4a8e3340cdb7c4&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-be5c92f841e5eacc9ca4d01b66767826~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781542339&amp;auth_key=1781542339-0-0-e25d6be3126a0e21b432581382194be1&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p><img src=\"https:\/\/picx.zhimg.com\/80\/v2-4817c2f8bd9586301a61909a7255591e_720w.png\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/pic1.zhimg.com\/v2-4817c2f8bd9586301a61909a7255591e.png\" data-watermark-src=\"https:\/\/picx.zhimg.com\/v2-a2b40865a9771dc74f5ee1fb67d27040.png\" data-private-watermark-src=\"\" \/><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1285 -->\n\n\t\n\t\t\n<article id=\"post-1283\" class=\"post-1283 post type-post status-publish format-standard hentry category-news tag-nano-liposomal-haematococcus-astaxanthin-anti-oxidation tag-resists-uva tag-smoothness\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1283\" title=\"Permalink to PuriActives\u00ae PALMITOYL TRYPTAMINE\" rel=\"bookmark\">PuriActives\u00ae PALMITOYL TRYPTAMINE<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1283\" title=\"21:20\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-06-14T21:20:14+08:00\">06\/14\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-06-14T21:20:14+08:00\">06\/14\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<p>Available in Pure Crystalline Powder &amp; NanoActive\u00ae Water-Soluble Liquid Grades<\/p>\n<h2>1. PRODUCT IDENTIFICATION<\/h2>\n<ul>\n<li>Trade Name: PuriActives\u00ae PALMITOYL TRYPTAMINE (Pure Powder Grade) \/ NanoActive\u00ae PALMITOYL TRYPTAMINE (Water-Soluble Liquid Grade)<\/li>\n<\/ul>\n<p>INCI Name (US\/EU):<\/p>\n<ul>\n<li>Pure Powder Grade: Palmitoyl Tryptamine<\/li>\n<li>NanoActive\u00ae Grade: Water, Glycerin, Phospholipids, Palmitoyl Tryptamine, Caprylic\/Capric Triglyceride<\/li>\n<li>Chemical Name (Active): N-[2-(1H-indol-3-yl)ethyl]hexadecanamide<\/li>\n<li>CAS Number (Active): 21469-15-8<\/li>\n<li>Molecular Formula (Active): C\u2082\u2086H\u2084\u2082N\u2082O<\/li>\n<li>Molecular Weight (Active): 398.63 g\/mol<\/li>\n<li>Chemical Structure: CH\u2083-(CH\u2082)\u2081\u2084-CO-NH-CH\u2082-CH\u2082-C\u2088H\u2085NH<\/li>\n<\/ul>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-0cc38cfc6812ee7969d1cb3cb3a741c0~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781443306-0-0-d994f07c0fa5e1e9272b8b3dcc9aaf2b&amp;bizSceneCode=article_draft&amp;expiration=1781443306&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"1080\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-0cc38cfc6812ee7969d1cb3cb3a741c0~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781446217&amp;auth_key=1781446217-0-0-da556a1dc5ed549aeb142f5fe60f8eac&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2049599573971170849\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-a02aeff2f343c3fe6b3a2801c550dc95~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781446218&amp;auth_key=1781446218-0-0-7b064b38f43cf2773ed980eb93c8fc7c&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>2. PRODUCT DESCRIPTION<\/h2>\n<p><b>PuriActives\u00ae Palmitoyl Tryptamine <\/b>is a high-purity, bio-mimetic lipid-alkaloid conjugate engineered to deliver profound neuro-cosmetic soothing and cellular anti-inflammatory benefits. By coupling the potent neuro-active molecule tryptamine with palmitic acid, this compound exhibits exceptional skin-penetration kinetics and lipid-membrane affinity.<\/p>\n<p>To address the inherent solubility limitations of the pure lipophilic crystalline powder in water-based cosmetic architectures, PuriPharm offers <b>NanoActive\u00ae Palmitoyl Tryptamine<\/b>. Utilizing state-of-the-art advanced nano-delivery technology, this grade encapsulates the active within a biomimetic phospholipid bilayer membrane (average particle size &lt; 100 nm). This advanced delivery system transforms a highly lipophilic compound into a thermodynamic-stable, optically transparent, and water-dispersible active, dramatically boosting skin bioavailability and offering effortless formulation flexibility.<\/p>\n<h2>3. CORE MECHANISMS OF ACTION<\/h2>\n<h2>A. Neurogenic Soothing via TRP Channel Modulation<\/h2>\n<p>Sensitive skin is characterized by hyper-excited sensory nerve endings. Palmitoyl Tryptamine acts as a gentle, soothing modulator of neurogenic pathways. It targets transient receptor potential (TRP) channels, specifically mitigating the over-activation of TRPV1 (capsaicin receptor), which in turn suppresses sensations of burning, stinging, tightness, and itching.<\/p>\n<h2>B. Anti-Inflammaging &amp; PPAR-\u03b1 Activation<\/h2>\n<p>Similar to endogenous endocannabinoid-like molecules (such as Palmitoylethanolamide \/ PEA), Palmitoyl Tryptamine serves as an agonist for the nuclear receptor PPAR-\u03b1 (Peroxisome Proliferator-Activated Receptor Alpha). This activation triggers downstream anti-inflammatory cascades:<\/p>\n<ul>\n<li>Inhibits the release of pro-inflammatory cytokines such as IL-1\u03b2, IL-6, and TNF-\u03b1.<\/li>\n<li>Suppresses mast cell degranulation, mitigating sudden skin redness and histamine-induced itchiness.<\/li>\n<\/ul>\n<h2>C. Melatonin Pathway Synergy &amp; Circadian Repair<\/h2>\n<p>Because tryptamine is an biochemical precursor in the melatonin and serotonin synthesis pathways, topical application of Palmitoyl Tryptamine supports the skin\u2019s nocturnal repair mechanisms. It enhances the skin\u2019s endogenous defense against oxidative stress induced by ultraviolet (UV) radiation and blue light, helping to maintain cellular homeostasis during sleep.<\/p>\n<h2>D. Enhanced Bioavailability via Lipophilic Vectoring &amp; Nano-Carrier Delivery<\/h2>\n<ul>\n<li>Pure Powder: Conjugation with palmitic acid increases the partition coefficient (log P \u2248 6.83), allowing the active to integrate seamlessly into the intercellular lipid matrix of the stratum corneum.<\/li>\n<li>NanoActive\u00ae Liquid: The phospholipid membrane of the nano-carriers fuses directly with the lipid bilayers of the stratum corneum. This bypasses the rate-limiting barrier of intercellular lipid transport, creating a &#8220;depot effect&#8221; in the viable epidermis and accelerating cellular uptake of the active molecule.<\/li>\n<\/ul>\n<h2>4. TECHNICAL SPECIFICATIONS<\/h2>\n<p>[Grade A] PuriActives\u00ae PALMITOYL TRYPTAMINE (Pure Powder)<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-273e7b15b6062f5156c67f680f31a7be~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781443306-0-0-cae4bd48c260bb4350793aefd25a83bf&amp;bizSceneCode=article_draft&amp;expiration=1781443306&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"495\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-273e7b15b6062f5156c67f680f31a7be~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781446217&amp;auth_key=1781446217-0-0-40692e2fe88fe0c77f8c26fda475df6e&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-8c2b04a9676edd894d844d873ebd3490~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781446218&amp;auth_key=1781446218-0-0-a72b02df60bb5df5783ec9102ed92d3c&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>[Grade B] NanoActive\u00ae PALMITOYL TRYPTAMINE (Water-Soluble Liquid)<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-80f7ea15d7996ffa19274077224df7cf~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781443306-0-0-c38c9602263b2677f9481d4a3b5b6d61&amp;bizSceneCode=article_draft&amp;expiration=1781443306&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"564\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-80f7ea15d7996ffa19274077224df7cf~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781446217&amp;auth_key=1781446217-0-0-b24d7e3fd798ba1bc8542a15865a4f6f&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-38a32b6a0e016d709251a8140206eca1~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781446218&amp;auth_key=1781446218-0-0-c654bc269a23fd291ec7e4e06504e1a6&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Microbiological Specifications (Both Grades)<\/p>\n<ul>\n<li>Total Aerobic Plate Count: \u2264 100 CFU\/g<\/li>\n<li>Yeasts and Molds: \u2264 10 CFU\/g<\/li>\n<li>Pathogens (E. coli, S. aureus, P. aeruginosa): Negative\/g<\/li>\n<\/ul>\n<h2>5. COSMETIC BENEFITS &amp; CLINICAL CLAIMS<\/h2>\n<ul>\n<li>Instant Neuro-Soothing: Rapidly reduces sensory discomfort, itching, and neuro-sensitivity.<\/li>\n<li>Anti-Redness &amp; Erythema Control: Dampens micro-vascular reactivity and controls flushing in rosacea-prone skin.<\/li>\n<li>Skin Barrier Recovery: Accelerates epidermal barrier repair and decreases trans-epidermal water loss (TEWL).<\/li>\n<li>Intense Inflammaging Defense: Protects structural proteins (collagen and elastin) from enzymatic degradation caused by chronic low-grade inflammation.<\/li>\n<li>Chronobiological Renewal: Aids in resetting skin repair rhythms, restoring a radiant and rested complexion overnight.<\/li>\n<\/ul>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-420a51dbb64183dba5746ec761c2bac2~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781443306-0-0-b40c08bd6269d2b07c741aed4c431852&amp;bizSceneCode=article_draft&amp;expiration=1781443306&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"721\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-420a51dbb64183dba5746ec761c2bac2~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781446217&amp;auth_key=1781446217-0-0-c69cabf0d3c93fc644af8d2765ac7240&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2049599573971170849\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-19fbfb6dc7a20d378e843177505b0cc3~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781446218&amp;auth_key=1781446218-0-0-df6c964cd6f60c51ec753a1d3e7d27c0&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>6. FORMULATION &amp; PROCESSING GUIDELINES (PURE POWDER)<\/h2>\n<h2>A. Recommended Usage Levels<\/h2>\n<ul>\n<li>Daily Soothing &amp; Maintenance Creams: 0.05% &#8211; 0.2%<\/li>\n<li>Intensive SOS \/ Post-Procedure Care: 0.2% &#8211; 0.5%<\/li>\n<\/ul>\n<h2>B. Solubility &amp; Incorporation<\/h2>\n<ul>\n<li>Oil Phase: Soluble in hot cosmetic esters and lipids (e.g., Caprylic\/Capric Triglyceride, Squalane, C12-15 Alkyl Benzoate) at 75\u00b0C &#8211; 80\u00b0C.<\/li>\n<li>Water Phase: Insoluble in water.<\/li>\n<\/ul>\n<h2>C. Processing Temperature<\/h2>\n<p>\u25cfStable at temperatures up to 85\u00b0C. It is recommended to dissolve the active in the oil phase before emulsification.<\/p>\n<h2>7. FORMULATION &amp; PROCESSING GUIDELINES (NANOACTIVE\u00ae LIQUID)<\/h2>\n<h2>A. Recommended Usage Levels<\/h2>\n<ul>\n<li>Daily Soothing Serums &amp; Toners: 1.0% &#8211; 4.0% (Equivalent to 0.05% &#8211; 0.2% pure active)<\/li>\n<li>High-Concentration Clinical Soothing Ampoules: 4.0% &#8211; 10.0% (Equivalent to 0.2% &#8211; 0.5% pure active)<\/li>\n<\/ul>\n<h2>B. Solubility &amp; Incorporation<\/h2>\n<ul>\n<li>Water Phase: 100% dispersible in water. It yields an elegant, optically transparent solution, ideal for clear gel, serum, toner, and essence formulations.<\/li>\n<li>Incorporation: Highly recommended to add to the water phase or post-emulsification phase during the cooling stage at temperatures below 40\u00b0C.<\/li>\n<\/ul>\n<h2>C. Processing Guidelines &amp; Shear Sensitivity<\/h2>\n<ul>\n<li>Avoid exposing NanoActive\u00ae grade to high-shear homogenization equipment (e.g., rotor-stator homogenizers) for prolonged periods, as extreme shear can disrupt the lipid vesicle bilayers. Use paddle stirring or gentle marine propellers to disperse.<\/li>\n<\/ul>\n<h2>D. pH Stability (NanoActive\u00ae)<\/h2>\n<ul>\n<li>Optimum stability is observed within a pH range of 4.5 &#8211; 6.5.<\/li>\n<\/ul>\n<h2>8. STORAGE, SHELF LIFE &amp; REGULATORY<\/h2>\n<ul>\n<li><b>Storage Conditions: <\/b>Store in the original, tightly sealed container.<\/li>\n<li>Pure Powder: Keep in a cool, dry, and well-ventilated area, preferably refrigerated at 2\u00b0C &#8211; 8\u00b0C for long-term storage.<\/li>\n<li>NanoActive\u00ae Liquid: Do not freeze. Store at 4\u00b0C &#8211; 25\u00b0C, protected from direct sunlight and heat.<\/li>\n<li><b>Shelf Life: <\/b>24 months from the date of manufacture when stored under prescribed conditions.<\/li>\n<li><b>Regulatory Compliance: <\/b>Approved for use in cosmetics worldwide (including EU, USA, and China IECIC listing). Vegan-compliant, cruelty-free, and non-GMO.<\/li>\n<\/ul>\n<p>Disclaimer: The information contained in this document is provided in good faith and is based on our current technical knowledge. Formulation results may vary depending on other raw materials and processing equipment used. It is the formulator&#8217;s responsibility to conduct final product safety and efficacy tests.<\/p>\n<p><img src=\"https:\/\/pic1.zhimg.com\/80\/v2-e23d9ff3e08406b89a6ed2ba5f539959_720w.png\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/picx.zhimg.com\/v2-e23d9ff3e08406b89a6ed2ba5f539959.png\" data-watermark-src=\"https:\/\/picx.zhimg.com\/v2-6ceac7fbbc30412642e4fef9a0015526.png\" data-private-watermark-src=\"\" \/><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1283 -->\n\n\t\n\t\t\n<article id=\"post-1281\" class=\"post-1281 post type-post status-publish format-standard hentry category-news tag-anti-dandruff tag-anti-dermatitis tag-anti-oxidation\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1281\" title=\"Permalink to PuriActives\u00ae SupraSalix Supramolecular Salicylic Acid\" rel=\"bookmark\">PuriActives\u00ae SupraSalix Supramolecular Salicylic Acid<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1281\" title=\"19:45\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-06-13T19:45:26+08:00\">06\/13\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-06-13T19:45:26+08:00\">06\/13\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<h2>Technical Dossier | PuriPharm Co. Ltd. \u2014\u2014 A Breakthrough 3-in-1 Targeted Solution: Sebum Control \u2022 Barrier Repair \u2022 Microbiome Balance<\/h2>\n<h2>1. Product Overview<\/h2>\n<p>Traditional Salicylic Acid (SA) is highly efficacious in anti-acne and sebum control treatments. However, its free-acid form is notoriously associated with adverse effects, including severe irritation, flaking, and disruption of the skin barrier. To address this persistent industry challenge, PuriPharm Co. Ltd. has engineered PuriActives\u00ae SupraSalix (Supramolecular Salicylic Acid), specifically designed for modern sensitive skin and compromised complexions.<\/p>\n<p>Powered by cutting-edge supramolecular self-assembly technology, PuriActives\u00ae SupraSalix utilizes a core of Salicylic Acid and Zinc Amino Acid. It innovatively integrates the biomimetic repair network of Xyloglucan and the prebiotic engine of \u03b1-Glucan Oligosaccharide.<\/p>\n<p>This active ingredient shatters the traditional paradigm that &#8220;anti-acne equals barrier damage.&#8221; By achieving a 4D synergistic effect\u2014sustained-release desensitization, comedolytic sebum control, biomimetic repair, and microbiome balance\u2014it stands as a next-generation, ultra-mild anti-acne active formulated for sensitive skin, acne vulgaris, and seborrheic dermatitis.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-cabf53711c10a5b5fa2f41084af26dc0~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781351086-0-0-8c8a7bb7c707043f43102ead796aad9b&amp;bizSceneCode=article_draft&amp;expiration=1781351086&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"469\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-cabf53711c10a5b5fa2f41084af26dc0~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781354115&amp;auth_key=1781354115-0-0-77e783f8ad6caaeda43616b3aa975931&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-a93019599d7a7927774de1d0d1b91258~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781354115&amp;auth_key=1781354115-0-0-134a86d44db202d90b7bb6f59ef49ae8&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>2. Core Components &amp; Mechanism of Action<\/h2>\n<p>The exceptional efficacy of PuriActives\u00ae SupraSalix originates from its meticulously designed matrix of four core components:<\/p>\n<h2>2.1 The Core Anti-Acne Engine: Salicylic Acid &amp; Zinc Amino Acid<\/h2>\n<p>A supramolecular network cleverly conjugates Salicylic Acid with Zinc Amino Acid (primarily Zinc Glycinate) to achieve &#8220;reduced toxicity, enhanced efficacy&#8221; alongside kinetic sustained release.<\/p>\n<ul>\n<li>Salicylic Acid: A lipophilic BHA that penetrates deep into hair follicles to dissolve keratin plugs and sebum, exerting potent comedolytic action. Simultaneously, it inhibits COX enzyme activity to block the production of pro-inflammatory mediators like prostaglandins.<\/li>\n<li>Zinc Ion: An essential trace element. It inhibits 5\u03b1-reductase activity, significantly reducing sebum hypersecretion at the source. It also disrupts pathogenic biofilms for broad-spectrum antimicrobial action while accelerating wound healing and tissue remodeling.<\/li>\n<li>Amino Acid (e.g., Glycine): The smallest amino acid. It not only acts as a carrier to enhance Zinc&#8217;s skin penetration but is also a critical component of the Natural Moisturizing Factor (NMF) and collagen, effectively soothing localized dryness caused by acid peeling.<\/li>\n<\/ul>\n<h2>2.2 The Invisible Biomimetic Barrier: Xyloglucan<\/h2>\n<p>A natural polysaccharide extracted from Tamarind seeds, widely recognized in pharmaceutical applications for treating eczema, dermatitis, and psoriasis.<\/p>\n<ul>\n<li>&#8220;Second Skin&#8221; Effect: Exhibits outstanding film-forming properties, creating a breathable, invisible biomimetic shield on the skin surface to defend against external aggressors (e.g., PM2.5, allergens).<\/li>\n<li>Deep Hydration &amp; Repair: Significantly reduces Transepidermal Water Loss (TEWL), providing a moist healing microenvironment for a compromised stratum corneum. It synergizes with amino acids to accelerate barrier repair and diminish erythema (redness) and acne marks.<\/li>\n<\/ul>\n<h2>2.3 The Microbiome Modulator: \u03b1-Glucan Oligosaccharide<\/h2>\n<p>A highly active, plant-derived prebiotic.<\/p>\n<ul>\n<li>Targeted Feeding: Selectively promotes the proliferation of beneficial skin flora (e.g., Staphylococcus epidermidis) while remaining indigestible to pathogens (e.g., Cutibacterium acnes, Malassezia).<\/li>\n<li>Competitive Inhibition: By robustly cultivating beneficial bacteria to occupy the ecological niche, it competitively inhibits the microorganisms responsible for acne and seborrheic dermatitis, cutting off the root cause of recurrent breakouts from an ecological standpoint.<\/li>\n<\/ul>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-647ea71b3c9fbce1e623a11fed4fd970~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781351086-0-0-a1c6741fd5c6cfa5f8c0a304b94a86a5&amp;bizSceneCode=article_draft&amp;expiration=1781351086&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"720\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-647ea71b3c9fbce1e623a11fed4fd970~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781354115&amp;auth_key=1781354115-0-0-76558d8732ba00dbc9709d557813fb1a&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2049213266774249979\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-e3028f83f99a8b6d1ee20ca9b8786815~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781354115&amp;auth_key=1781354115-0-0-d744887bbf9df85eb1f89dcb033d5d9a&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>3. 4D Synergy Matrix<\/h2>\n<p>PuriActives\u00ae SupraSalix is not a simple physical blend. Through PuriPharm&#8217;s supramolecular technology, it establishes a 1+1+1&gt;3 synergistic network:<\/p>\n<ul>\n<li>1D Clear &amp; Control: SA pore unclogging + Zinc&#8217;s active sebaceous inhibition. A dual-action approach to drastically improve oily skin and congested pores.<\/li>\n<li>2D Targeted Anti-inflammatory: Zinc (inhibiting the upstream NF-kB pathway) combined with SA (inhibiting the downstream COX pathway). Delivers rapid erythema reduction and soothes inflamed papules.<\/li>\n<li>3D Biomimetic Repair: Xyloglucan&#8217;s physical film-forming + Amino acid&#8217;s biochemical hydration. Perfectly neutralizes the harsh peeling effects of acids, enabling simultaneous &#8220;Clear &amp; Repair.&#8221;<\/li>\n<li>4D Microbiome Balance: \u03b1-Glucan Oligosaccharide reconstructs the microbial barrier, complementing the antimicrobial properties of Zn and SA. It systematically improves acne-prone and reactive skin profiles, preventing future relapses.<\/li>\n<\/ul>\n<h2>4. Core Advantages vs. Benchmark<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-8a5f617ddd49719368e76120ce053893~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781351086-0-0-bb22847faf1418d761d0187f78ecfdff&amp;bizSceneCode=article_draft&amp;expiration=1781351086&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"431\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-8a5f617ddd49719368e76120ce053893~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781354114&amp;auth_key=1781354114-0-0-1e7014eaf1ab41d69fe03a68076779bf&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-eb0268f23ce512f542f67b76cc2d0b2a~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781354115&amp;auth_key=1781354115-0-0-cb44daf41839f2c7ebd158d6a9885e9b&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>5. Applications &amp; Formulation Guidelines<\/h2>\n<p>PuriActives\u00ae SupraSalix demonstrates exceptional compatibility and solubility, making it highly versatile for various cosmetic formats including toners, serums, emulsions, gels, and wash-off products.<\/p>\n<p>Primary Application Scenarios:<\/p>\n<ol>\n<li>Professional Acne\/Comedone Care: Anti-acne serums, spot treatment gels, chemical peel solutions (highly recommended for sensitive skin peeling).<\/li>\n<li>Sebum &amp; Pore Management: Pore-refining toners, mattifying\/balancing emulsions, deep-cleansing mud masks.<\/li>\n<li>Seborrheic Dermatitis &amp; Scalp Care: Anti-dandruff shampoos, scalp oil-control serums, scalp microbiome treatments.<\/li>\n<li>SOS Redness &amp; Repair Care: Post-extraction soothing treatments, anti-inflammatory products for barrier-compromised phases.<\/li>\n<\/ol>\n<p>Formulation Guidelines:<\/p>\n<ul>\n<li>Appearance: (Please refer to the actual product COA)<\/li>\n<li>Solubility: Excellent water solubility; easily incorporated into the aqueous phase.<\/li>\n<li>Recommended Dosage: 1.0% &#8211; 5.0% (Depending on specific product claims and efficacy substantiation).<\/li>\n<li>Optimal pH Range: 4.0 &#8211; 6.5 (A mildly acidic environment favors the stability of the supramolecular network and SA activity. Strongly alkaline environments should be avoided).<\/li>\n<li>Compatibility: Pairs excellently with active ingredients such as Niacinamide, Hyaluronic Acid, and Ceramides. Note: Avoid prolonged co-existence with high concentrations of strong metal chelating agents (e.g., EDTA) in the same system to prevent competitive disruption of the Zinc complex structure.<\/li>\n<\/ul>\n<p>Copyright Statement: PuriActives\u00ae is a registered trademark of PuriPharm Co. Ltd. The information provided in this document is based on current scientific research and in vitro \/ in vivo testing, intended solely as a reference for formulators and R&amp;D professionals.<\/p>\n<p><img src=\"https:\/\/pica.zhimg.com\/80\/v2-e23d9ff3e08406b89a6ed2ba5f539959_720w.png\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/pica.zhimg.com\/v2-e23d9ff3e08406b89a6ed2ba5f539959.png\" data-watermark-src=\"https:\/\/picx.zhimg.com\/v2-6ceac7fbbc30412642e4fef9a0015526.png\" data-private-watermark-src=\"\" \/><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1281 -->\n\n\t\n\t\t\n<article id=\"post-1278\" class=\"post-1278 post type-post status-publish format-standard hentry category-news tag-nano-liposomal-haematococcus-astaxanthin-anti-oxidation tag-stratum-corneum-repair\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1278\" title=\"Permalink to PuriActives\u00ae Sodium Algin Sulfate The Marine-Derived GAGs Biomimetic for Ultimate Cellular Regeneration\" rel=\"bookmark\">PuriActives\u00ae Sodium Algin Sulfate The Marine-Derived GAGs Biomimetic for Ultimate Cellular Regeneration<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1278\" title=\"21:17\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-06-09T21:17:21+08:00\">06\/09\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-06-09T21:17:21+08:00\">06\/09\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<p>Company: PuriPharm Co. Ltd.<\/p>\n<p>Product Category: Active Ingredient \/ Anti-Aging &amp; Skin Barrier Repair<\/p>\n<p>Format: Technical &amp; Marketing Brochure<\/p>\n<h2>1. Executive Summary<\/h2>\n<p>PuriActives\u00ae Sodium Algin Sulfate is an advanced, highly purified sulfated polysaccharide derived from premium marine brown algae. Engineered through precise biomimetic biotechnology, it acts as a structural and functional analogue to endogenous Glycosaminoglycans (GAGs), specifically Heparan Sulfate.<\/p>\n<p>By mimicking the extracellular matrix&#8217;s (ECM) natural biological environment, Sodium Algin Sulfate plays a crucial role in stabilizing growth factors, reducing chronic inflammation (&#8220;inflammaging&#8221;), and accelerating deep skin tissue repair. It is the ultimate marine-biotech solution for premium anti-aging, soothing, and post-procedure recovery formulations.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-0976662ba2a19e9c677832b51ccb4b41~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781011081-0-0-0ae7af696e1e43edf530935e79064adb&amp;bizSceneCode=article_draft&amp;expiration=1781011081&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"752\" data-rawheight=\"1125\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-0976662ba2a19e9c677832b51ccb4b41~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781014407&amp;auth_key=1781014407-0-0-1d3658bc8c4b9bcc829c0c133859cd77&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2047788426120914539\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-e8b4b4e29e667bcd503294e1a3a583e5~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781014407&amp;auth_key=1781014407-0-0-2488a40ea9f989f20647d3fcda564eca&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>2. The Scientific Rationale: A Master of the Extracellular Matrix (ECM)<\/h2>\n<p>As skin ages, the natural pool of Heparan Sulfate in the ECM depletes, leading to structural collapse, impaired cellular communication, and accelerated wrinkling.<\/p>\n<p>PuriActives\u00ae Sodium Algin Sulfate features a precisely controlled Degree of Sulfation (DS) that closely mimics human GAGs.<\/p>\n<ul>\n<li>Growth Factor Stabilization: Its negatively charged sulfated topology allows it to bind specifically to endogenous growth factors (e.g., FGF, EGF, TGF-\u03b2), protecting them from proteolytic degradation and amplifying their signaling pathways for collagen synthesis.<\/li>\n<li>MMP Inhibition: It competitively binds to and inhibits Matrix Metalloproteinases (MMPs), particularly Hyaluronidase and Elastase, preserving the skin&#8217;s natural hyaluronic acid and elastin reservoirs.<\/li>\n<\/ul>\n<h2>3. Core Clinical Efficacies<\/h2>\n<h2>I. Profound Anti-Aging &amp; Wrinkle Reduction<\/h2>\n<p>By acting as a biological reservoir for growth factors, Sodium Algin Sulfate stimulates fibroblast proliferation and upregulates the synthesis of Collagen I and III. It restores the dermal-epidermal junction (DEJ) architecture, resulting in visibly firmer skin and a reduction in fine lines.<\/p>\n<h2>II. Rapid Barrier Repair &amp; Soothing<\/h2>\n<p>Exhibiting exceptional anti-inflammatory properties, it actively downregulates pro-inflammatory cytokines (such as IL-1\u03b1 and TNF-\u03b1). It accelerates epidermal re-epithelialization, making it highly effective for sensitive skin, rosacea, and post-aesthetic procedure care (e.g., post-laser, post-peel).<\/p>\n<h2>III. Deep, Sustained Hydration<\/h2>\n<p>Unlike standard humectants that merely hold water on the surface, its high molecular weight and dense charge network create a breathable, 3D bio-polymeric film. This shields against trans-epidermal water loss (TEWL) while actively modulating cellular hydration channels from within.<\/p>\n<h2>4. Technical Specifications &amp; Formulation Guidelines<\/h2>\n<ul>\n<li>INCI Name: Sodium Algin Sulfate (and) Water (Aqua)<\/li>\n<li>Appearance: Clear to slightly yellowish, viscous liquid.<\/li>\n<li>Odor: Characteristic (mild marine origin).<\/li>\n<li>Solubility: 100% soluble in water. Insoluble in oils and high concentrations of ethanol.<\/li>\n<li>pH Value (at 20\u00b0C): 5.0 \u2013 7.5<\/li>\n<li>Recommended Usage Level: 1.0% \u2013 5.0%<\/li>\n<\/ul>\n<p>Formulation Advantages (The PuriPharm Edge):<\/p>\n<ul>\n<li>High Compatibility: Compatible with a wide range of cosmetic chassis, including clear serums, O\/W emulsions, and hydrogels.<\/li>\n<li>Stability: Highly stable against thermal stress (up to 80\u00b0C) and light. Can be added to the aqueous phase before homogenization or post-added during the cooling phase below 40\u00b0C.<\/li>\n<li>Synergistic Potential: Pairs perfectly with peptides, ceramides, and PuriPharm&#8217;s NanoActive\u00ae encapsulates (like NanoActive\u00ae Phloretin) for comprehensive anti-aging and barrier-repair protocols.<\/li>\n<\/ul>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-ce6029b810affb9e76bc306ea14d3028~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1781011081-0-0-d5c0c221125346c5d32fb5b7f3cb0356&amp;bizSceneCode=article_draft&amp;expiration=1781011081&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"717\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-ce6029b810affb9e76bc306ea14d3028~resize:0:q75.png?source=1f5c5e47&amp;expiration=1781014406&amp;auth_key=1781014406-0-0-3606d11c6b2a16064f8164a9af929ea8&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-cf2d3db998f06693222240d27dc51615~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1781014407&amp;auth_key=1781014407-0-0-7a0e18358127ba849b93ca717b90df17&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>5. Application Horizons<\/h2>\n<ul>\n<li>Intensive Anti-Aging Serums: To restructure the dermal matrix and enhance firmness.<\/li>\n<li>Dermatological Soothing Creams: For hypersensitive, reactive, or compromised skin.<\/li>\n<li>Post-Procedure Care: Accelerating recovery after laser treatments, micro-needling, or chemical peels.<\/li>\n<li>Scalp Care Therapies: Reducing scalp inflammation and maintaining follicular ECM health.<\/li>\n<\/ul>\n<p>PuriPharm Co. Ltd.<\/p>\n<p>Active Science. Advanced Delivery. Real Impact.<\/p>\n<p>For technical dossiers, material safety data sheets (MSDS), or formulation assistance, please contact our R&amp;D support team.<\/p>\n<p>Email: Service@puripharm.com | Web: www.PuriActives.com<\/p>\n<p><img src=\"https:\/\/pica.zhimg.com\/80\/v2-e23d9ff3e08406b89a6ed2ba5f539959_720w.png\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/pica.zhimg.com\/v2-e23d9ff3e08406b89a6ed2ba5f539959.png\" data-watermark-src=\"https:\/\/pic1.zhimg.com\/v2-6ceac7fbbc30412642e4fef9a0015526.png\" data-private-watermark-src=\"\" \/><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1278 -->\n\n\t\n\t\t\n<article id=\"post-1273\" class=\"post-1273 post type-post status-publish format-standard hentry category-news tag-anti-inflammatory tag-bioactive-ingredients\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1273\" title=\"Permalink to NanoActive&#x2122; Phloretin Redefining Efficacy with Advanced Nano-Delivery Technology\" rel=\"bookmark\">NanoActive&#x2122; Phloretin Redefining Efficacy with Advanced Nano-Delivery Technology<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1273\" title=\"23:45\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-06-05T23:45:14+08:00\">06\/05\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-06-05T23:47:41+08:00\">06\/05\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<h2>1. Product Overview<\/h2>\n<p>Phloretin, an extraordinary dihydrochalcone polyphenol derived from the root bark of Malus domestica (apple tree), is celebrated for its multi-functional benefits: remarkable tyrosinase inhibition, potent radical scavenging, and cellular DNA protection. However, traditional crystalline Phloretin is notoriously difficult to formulate due to poor water solubility, high oxidation susceptibility, and inability to penetrate the stratum corneum barrier effectively.<\/p>\n<p>PuriPharm introduces NanoActive&#x2122; Phloretin\u2014powered by our proprietary Advanced Nano-Delivery System Technology. By encapsulating Phloretin within a sub-50nm nanostructured lipid matrix, we have unlocked its full potential, transforming nature&#8217;s most potent antioxidant into a stable, highly bioavailable formulation solution.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-c9856d41bd9f5585475b8af6dab477a3~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780674565-0-0-9d6acc9534bdb761e4bf496465b0980f&amp;bizSceneCode=article_draft&amp;expiration=1780674565&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"720\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-c9856d41bd9f5585475b8af6dab477a3~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780678001&amp;auth_key=1780678001-0-0-63a54f2e0f8543071004b60b3e2b2f75&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2046376228542747699\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-9266038cc9a2489c380d3e21412ea3e2~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780678002&amp;auth_key=1780678002-0-0-c5458b5858940b2f8fbce37953147348&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>2. Key Benefits at a Glance<\/h2>\n<p>Breakthrough Bioavailability: Amphiphilic architecture enables seamless delivery across skin barriers.<\/p>\n<p>Enhanced Stability: Protects the active payload from premature oxidation and degradation.<\/p>\n<p>Formulation Freedom: Cold-processable, 100% water-dispersible, and prevents recrystallization or color shift.<\/p>\n<p>Unmatched Potency: Delivers 94% radical scavenging efficiency and powerful tyrosinase inhibition (IC50 = 37.5 \u03bcmol\/L).<\/p>\n<h2>3. The Science Behind the Innovation<\/h2>\n<h2>Advanced Whitening &amp; Melanin Regulation<\/h2>\n<p>Acts at the cellular level to inhibit tyrosinase activity. Fades post-inflammatory hyperpigmentation (PIH) and dramatically improves skin luminosity (L* value) without irritation.<\/p>\n<h2>Broad-Spectrum Antioxidant Matrix<\/h2>\n<p>Neutralizes reactive oxygen species (ROS) far more effectively than crystalline alternatives. The nano-delivery system ensures max dispersion in aqueous environments, achieving 94% scavenging efficiency\u2014outperforming standard Vitamin C.<\/p>\n<h2>Acne Mitigation &amp; Sebum Control<\/h2>\n<p>Targets sebaceous glands to reduce excess lipogenesis while inhibiting pro-inflammatory markers (PGE2, COX-2). Promotes a long-lasting matte finish and accelerates blemish recovery.<\/p>\n<h2>Deep Cellular DNA Defense<\/h2>\n<p>Shields cellular DNA from UV-induced Thymine Dimer formation and prevents the degradation of collagen by blocking MMP-9 expression, addressing the root causes of photoaging.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-b4fc35b05e49ae228827bd469d949bde~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780674565-0-0-ffa9ea3598392009c7271c370792cab8&amp;bizSceneCode=article_draft&amp;expiration=1780674565&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"721\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-b4fc35b05e49ae228827bd469d949bde~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780678001&amp;auth_key=1780678001-0-0-6965ce63144de3c14ebaba9b3c2112e2&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2046376228542747699\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-0848ce118e8a2da8067545475d2b2e24~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780678002&amp;auth_key=1780678002-0-0-8362df62bd90ad4a65911fa27c1f4a66&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>4. Applications &amp; Guidelines<\/h2>\n<p>INCI Name: Phloretin, Phospholipids, Caprylic\/Capric Triglyceride, Glycerin, Water<\/p>\n<p>Recommended Use Level: 0.5% \u2013 2.0%<\/p>\n<p>Optimal pH: 4.5 \u2013 6.5<\/p>\n<p>Applications: Premium skin brightening serums, daily antioxidant defense lotions, anti-acne spot treatments, and cellular repair night creams.<\/p>\n<p>Formulator&#8217;s Note: Ideal for cold-process formulations (add &lt; 45\u00b0C). Compatible with high-clarity clear serums, O\/W emulsions, and gels.<\/p>\n<h2>5. Storage &amp; Safety<\/h2>\n<p>Storage Conditions: Store between 4\u00b0C and 25\u00b0C. Protect from direct light and localized thermal sources. No strict cold chain required.<\/p>\n<p>Safety Profile: 0.0% irritation index in patch testing. Non-phototoxic, non-sensitizing, and GMO-free.<\/p>\n<p><img src=\"https:\/\/pica.zhimg.com\/80\/v2-e23d9ff3e08406b89a6ed2ba5f539959_720w.png\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/picx.zhimg.com\/v2-e23d9ff3e08406b89a6ed2ba5f539959.png\" data-watermark-src=\"https:\/\/picx.zhimg.com\/v2-6ceac7fbbc30412642e4fef9a0015526.png\" data-private-watermark-src=\"\" \/><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1273 -->\n\n\t\n\t\t\n<article id=\"post-1270\" class=\"post-1270 post type-post status-publish format-standard hentry category-news tag-anti-dermatitis tag-anti-inflammatory tag-nano-liposomal-haematococcus-astaxanthin-anti-oxidation\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1270\" title=\"Permalink to NanoActive PHLORETIN\" rel=\"bookmark\">NanoActive PHLORETIN<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1270\" title=\"19:09\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-06-02T19:09:08+08:00\">06\/02\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-06-02T19:09:08+08:00\">06\/02\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<p>&nbsp;<\/p>\n<h2>PURIPHARM: MOLECULAR EXCELLENCE<\/h2>\n<h2>Bridging Science &amp; Formulations<\/h2>\n<p>We empower global personal care brands through two core pillars of innovation, ensuring biological efficacy meets precise spatial delivery.<\/p>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-bfdfd49d204065455d80d4204bdbc5e0~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-22b1668a48a1a39866c77eb752b8c287&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"594\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-bfdfd49d204065455d80d4204bdbc5e0~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-d78f0ab3cde1c7201b3ad09f62ba26fd&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-df52ad82429b39f66aa62d139de1813c~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-9a7bd3e0dfabb17eb2aa5c59ba5d1413&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-6f47a22a31dcb13e99b7f314bda44ea5~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-b54034c79cc8c5ceb26912c4cf0a6f9b&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"886\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-6f47a22a31dcb13e99b7f314bda44ea5~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-e7fe2d1437a45673be7c444b127a3659&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2045219389142823837\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-f217edc10e3866127579f80be8d702a2~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401901&amp;auth_key=1780401901-0-0-5905335daa98db3d66eb145c52703292&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>NANOACTIVE\u00ae ARCHITECTURE<\/h2>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-dead3992a05f9d5e60b2e570791cbae3~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-9f9cc06b0145806cc42cc1f0c7cf417c&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"434\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-dead3992a05f9d5e60b2e570791cbae3~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-6c57ec8d188b5af99f581fe1a554b447&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-3eaead6491ac5b433fe70389c5db3f85~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-68af0519fcee28c3ce219ca65067727a&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>PHLORETIN: THE APPLE EXTRACT<\/h2>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-ae7e66f2863470b9a3b859a8ccc17003~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-66af5ce8c8fd97446b2b4a0f678cdc35&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"401\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-ae7e66f2863470b9a3b859a8ccc17003~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-707760f7095b8e9da5ed4fdf7b24ec36&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-d6f8e51ad4b1188433b871ea63d22b70~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-93aa1b68a052086b4f3d4bab74316b10&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>THE SOLUBILITY CHALLENGE<\/h2>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-17cdc5852a4835e38c01bc4d76816cfb~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-6ae295176dff8b99c451f163415a727b&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"313\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-17cdc5852a4835e38c01bc4d76816cfb~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-ed9023f21f5a8ba92d9945d7acaff0fa&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-2935183c26c68022ebfeff3925b5b1b0~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-cf7df52f6127c82c01749e50825989af&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>NANOACTIVE\u00ae PHLORETIN LIQUID<\/h2>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-cf085ab54bddbedd1076754dbf1ab042~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-92cab21dc6eadbd51e9ef4417b764e5b&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"408\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-cf085ab54bddbedd1076754dbf1ab042~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-0c02499d85f306a51a57cfd30578db24&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-28f5a73463968841f2b11bedbfce1bc0~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-d3e99605394f9e9f42537348fd44f17c&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>PRODUCT SPECIFICATIONS<\/h2>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-efb0419fff90cd65ba5f1159a11fe660~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-77a7d37da844dc03007c5edad26950f5&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"567\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-efb0419fff90cd65ba5f1159a11fe660~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-9b75a3e229944a2a8ed53981d021378f&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-89dbbd749a486bddd08bf94f1cd7e0d8~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-8b52b5cb515814a2e06a8fc37561022c&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>ANTIOXIDANT EFFICACY<\/h2>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-77c58748bbe3ed188a81ea9f4364ee44~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-62db2197a9c0f30b3d22e24e64684e17&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"255\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-77c58748bbe3ed188a81ea9f4364ee44~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-72eff9004e117a41d6df9b71a0388afd&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-bfe17b03ff41881bb9c256b8c52c19a2~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-45f818b4ed6c3dd26cfaa854c6b17bde&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>ANTI-INFLAMMATORY ACTION<\/h2>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-fb9aa7e2a86ef81e64facc224c8173e3~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-1779350aaf00ea9fed9867617485e353&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"536\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-fb9aa7e2a86ef81e64facc224c8173e3~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-86b5b247e7c9a6ca96dc65664f717d73&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2045219389142823837\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-2a369133841417eab902d97476b357b5~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401901&amp;auth_key=1780401901-0-0-a76caecc9f797cced92813a0e054a07e&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-3882f16e6798c28f5aeefd296b18de1b~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-b76ee3c7668cb8ec938fee151cabe254&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"497\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-3882f16e6798c28f5aeefd296b18de1b~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-8a109fda25f1862b6a70e1aa297b7a80&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-42a2f32697fe29cda40cc8cc1e925e1b~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-7fe339922809e88fcde9336dcafec792&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-8b07792df3fda0156e41eb036346f26e~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-b32cd37b4729e98a8176e737a900d660&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"605\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-8b07792df3fda0156e41eb036346f26e~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-f1cd56312a1255fdea2510a225986563&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2045219389142823837\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-f7e1fe1a1c0b871a181382d33e92a885~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401901&amp;auth_key=1780401901-0-0-b443b51cb5fd3b3e06cdf9d6883a93e6&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-87486dd4345aa5f73e3e1aa45d3ac0b9~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-dfa9d3e840c1c6d1d3100485ab782623&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-87486dd4345aa5f73e3e1aa45d3ac0b9~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-1e3afb809cd79319ce739d006b09dd64&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2045219389142823837\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-03d1c469eac4916c4947a2c1ebd2711e~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-ae7905de3e4d16cf59c28225af3d719d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>LUMINOSITY &amp; CLARITY<\/h2>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-27e38b13315fe395c0c356aa48bc5370~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-657fbe672deab7476cc557510f1ce871&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"224\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-27e38b13315fe395c0c356aa48bc5370~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-f4ef984d787fd17961b569037c89a4fa&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-a56bb990d82d281a7c6f773ea123ca72~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-9472663c33f39c659f28051de35eeb24&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>Biological Shield<\/h2>\n<p>Beyond traditional UV filters, NanoActive Phloretin prevents cellular damage at the DNA level:<\/p>\n<p>Prevents Thymine Dimer formation.<\/p>\n<p>Reduces p53 protein expression (Stress marker).<\/p>\n<p>Preserves Langerhans Cells for immune defense.<\/p>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-9a343c9e06fbb95b923542258bb0ad0a~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-e7039929c3602473c50b97c34daec671&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1000\" data-rawheight=\"1125\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-9a343c9e06fbb95b923542258bb0ad0a~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-c4adf3bfc67363e354d42a0d7dd082ce&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2045219389142823837\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-40a80035bbfcaaed6c19549e8b9e21f7~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401901&amp;auth_key=1780401901-0-0-b2613aab623b70a523b38ed13ae8220d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-8286d4d3afeb4e692ecdd9c5f75d6aab~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-e97dd97aec64019ae782d3d625380e2d&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-8286d4d3afeb4e692ecdd9c5f75d6aab~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-e4490c79e39c15fbb7c7f464c3c20caf&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2045219389142823837\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-b6234fec7bc90a609778ecea8defd913~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401901&amp;auth_key=1780401901-0-0-b48db70e96be461fbf27fc0e31728f79&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<h2>FORMULATOR&#8217;S ADVANTAGE<\/h2>\n<p><strong><img src=\"https:\/\/pic-out.zhimg.com\/v2-348479156c1d6a4c970bce885363f9f2~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-9978a2a214347c4f9507d57cc2d5800d&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"412\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-348479156c1d6a4c970bce885363f9f2~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-ef46860d91227eaf3e0a6350d8073531&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-b49b73f4d5cd3355f5ae4e9198d3c45f~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-046c9edc12a9eb37288ea7b2acdef5d2&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-5861cdf2808e4010bef21882205d99a5~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-392e214b29ecd17b9988c471d14903e2&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-5861cdf2808e4010bef21882205d99a5~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-99d158caab7d3a8143e2b4440a18c9fc&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2045219389142823837\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-bfc39494843b3f608055b5073d5b0e59~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401901&amp;auth_key=1780401901-0-0-22198eb11509cdaec29e0d955c37c940&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><img src=\"https:\/\/pic-out.zhimg.com\/v2-cce4aea2d9c7f2c5e7e6d0f0e303639c~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780398596-0-0-7b47fc03d4d0dbffecf8c5f96f937d4b&amp;bizSceneCode=article_draft&amp;expiration=1780398596&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-cce4aea2d9c7f2c5e7e6d0f0e303639c~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780401900&amp;auth_key=1780401900-0-0-393eb08a7ba057eed734ef1babee4b5d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2045219389142823837\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-ade963c988ac8608f2e244c04fdedf34~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780401901&amp;auth_key=1780401901-0-0-9222c2c0344f0bcc37ca8caa378f6688&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n<p><strong><img src=\"https:\/\/picx.zhimg.com\/80\/v2-e23d9ff3e08406b89a6ed2ba5f539959_720w.png\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/picx.zhimg.com\/v2-e23d9ff3e08406b89a6ed2ba5f539959.png\" data-watermark-src=\"https:\/\/pic1.zhimg.com\/v2-6ceac7fbbc30412642e4fef9a0015526.png\" data-private-watermark-src=\"\" \/><\/strong><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1270 -->\n\n\t\n\t\t\n<article id=\"post-1268\" class=\"post-1268 post type-post status-publish format-standard hentry category-news tag-anti-dermatitis tag-anti-free-radicals tag-anti-inflammatory\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1268\" title=\"Permalink to NanoActive Phloretin\" rel=\"bookmark\">NanoActive Phloretin<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1268\" title=\"18:44\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-06-02T18:44:36+08:00\">06\/02\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-06-02T18:44:36+08:00\">06\/02\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<h2>Advanced Nano-Delivery System for Enhanced Bioavailability &amp; Skin Penetration<\/h2>\n<h2>1.PRODUCT DESCRIPTION<\/h2>\n<p>NanoActive Phloretin is a highly advanced, water-dispersible nano-structured delivery system developed specifically for high-end cosmetic and dermatological formulations. Phloretin, a natural dihydrochalcone polyphenol primarily extracted from the root bark of apple trees (Malus domestica), possesses extraordinary biological properties including potent tyrosinase inhibition, broad-spectrum free radical scavenging, anti-inflammatory effects, and cellular DNA protection.<\/p>\n<p>Despite its remarkable therapeutic potential, raw crystalline Phloretin faces significant formulation constraints in personal care applications due to its severe lipophilicity, poor aqueous solubility, susceptibility to oxidation, and limited capacity to cross the thermodynamic barrier of the stratum corneum. PuriPharm overcomes these challenges by utilizing an innovative multi-lamellar liposomal architecture. By encapsulating Phloretin into nanostructured lipid matrices (Particle Size &lt; 50 nm), the system dramatically amplifies active molecule stability, optimizes delivery kinetics, and increases biological skin absorption without the use of irritating organic solvents or high alcohol levels.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-66458e8d63fe0796e8fa7e1602d51f80~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780397070-0-0-7d9d55e6e527f192bd470e4817f29f0d&amp;bizSceneCode=article_draft&amp;expiration=1780397070&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"828\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-66458e8d63fe0796e8fa7e1602d51f80~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780400315&amp;auth_key=1780400315-0-0-ce4ab8d59015ae4145012e9dc55b9901&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-6480fbbdea52778a70d6de0335fee6cf~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780400315&amp;auth_key=1780400315-0-0-c78c0be1f26d3acc32078b3475212acf&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>2.TECHNICAL SPECIFICATIONS<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-78a81f82ee9e78b50f4f324726133d2a~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780397070-0-0-c196fc572af745dabcd7293393f054ad&amp;bizSceneCode=article_draft&amp;expiration=1780397070&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"577\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-78a81f82ee9e78b50f4f324726133d2a~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780400315&amp;auth_key=1780400315-0-0-b2a47673081704b03b7bb214de459ec4&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-ad503c630130656b86defe30b87082f2~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780400315&amp;auth_key=1780400315-0-0-f7cc357eb8c76da030f1f13ed5baea31&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>3. BIOLOGICAL EFFICACY &amp; MECHANISMS<\/h2>\n<h2>3.1 Advanced Melanin Regulation &amp; Skin Whitening<\/h2>\n<p>NanoActive Phloretin acts as a highly effective inhibitor of mammalian tyrosinase, the rate-limiting enzyme in melanogenesis. It downregulates the conversion of L-tyrosine to L-DOPA, suppressing melanin synthesis at a cellular level. Clinical data exhibits an ultra-low half-maximal inhibitory concentration (IC50 = 37.5 \u03bcmol\/L), significantly outperforming traditional agents like Kojic Acid and Arbutin. The nano-delivery system ensures active transport into basal layer melanocytes, effectively fading post-inflammatory hyperpigmentation (PIH), evening out skin tone, and enhancing overall skin translucency and L* luminosity values.<\/p>\n<h2>3.2 Comprehensive Antioxidant &amp; Radical Scavenging Architecture<\/h2>\n<p>The polyphenolic structure of Phloretin offers powerful electron-donating properties to neutralize destructive reactive oxygen species (ROS). In comparative DPPH radical scavenging assays executed within aqueous environments, standard crystalline Phloretin displays suboptimal performance due to poor phase dispersion. Under identical aqueous test conditions:<\/p>\n<p>Pure Crystalline Phloretin: 42% free radical scavenging capacity.<\/p>\n<p>L-Ascorbic Acid (Vitamin C): 88% free radical scavenging capacity.<\/p>\n<p>NanoActive Phloretin: 94% radical scavenging efficiency.<\/p>\n<p>This distinct upregulation is driven by the amphiphilic lipid membrane shell, which maximizes contact surface area with free radicals in the water phase while preserving the inner molecular integrity of the active polyphenol.<\/p>\n<h2>3.3 Sebum Regulation &amp; Anti-Acne Efficacy<\/h2>\n<p>NanoActive Phloretin modifies the sebaceous microenvironment through multi-pathway mechanisms. It restricts excessive sebocyte lipogenesis, yielding a quantifiable reductions in sebum output and a long-lasting matte skin finish within 4 weeks. Concurrently, its strong anti-inflammatory properties inhibit Prostaglandin E2 (PGE2) secretion and cyclooxygenase-2 (COX-2) expression, yielding a 29.1% reduction in inflammatory pustules and acne-induced erythema.<\/p>\n<h2>3.4 Deep Cellular DNA Shield &amp; Photo-Aging Defense<\/h2>\n<p>Beyond traditional cosmetic benefits, NanoActive Phloretin provides genuine biological protection against ultraviolet (UV) irradiation. It enters viable epidermal layers to prevent the formation of cyclobutane pyrimidine dimers (Thymine Dimers) within cellular DNA. It dampens ultraviolet-induced p53 protein expression (a critical cellular stress indicator) and strictly blocks the up-regulation of Matrix Metalloproteinase-9 (MMP-9), thus preventing the structural breakdown of dermal collagen matrices and mitigating chronic photo-induced aging.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-7919fb909d8f9430a7c8a7d6f4f3380f~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780397071-0-0-22dd982d9318bbf13aea095a4249c68d&amp;bizSceneCode=article_draft&amp;expiration=1780397071&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"720\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-7919fb909d8f9430a7c8a7d6f4f3380f~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780400315&amp;auth_key=1780400315-0-0-cbd51101a91ebfcb56368ddb3e142dbb&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-2aaa2a7ed8ab23675174cf4d337acc60~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780400315&amp;auth_key=1780400315-0-0-e191bba0b463a16100601bd8859394b2&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h2>4. FORMULATION &amp; PROCESSING GUIDELINES<\/h2>\n<p>Formulator&#8217;s Edge: Unlike conventional crystalline Phloretin which is prone to recrystallization, sedimentation, and sudden color shifts, NanoActive Phloretin features excellent structural stability and effortless integration into diverse cosmetic chassis.<\/p>\n<p>Recommended Use Level: 0.5% \u2013 2.0% depending on the targeted performance profile (e.g., intensive whitening vs. daily antioxidant defense).<\/p>\n<p>Optimal Formulation pH: Safe and stable across a broad pH span of 3.0 to 6.5. Optimum shelf stability is achieved between pH 4.5 and 6.5.<\/p>\n<p>Processing Temperature: Cold processable. The product should preferably be incorporated during the final phase of manufacturing (cool-down stage) at temperatures below 45\u00b0C.<\/p>\n<p>Incorporation Technique: Directly add to the aqueous phase under gentle stirring. Compatible with surfactant systems, hydrogels, O\/W emulsions, and clear transparent serums without inducing recrystallization.<\/p>\n<h2>5. STORAGE, PACKAGING &amp; SHELF LIFE<\/h2>\n<ul>\n<li>Packaging: Available in 1 kg, 5 kg, and 25 kg food-grade, UV-shielded polyethylene containers.<\/li>\n<li>Storage Conditions: Store in the original sealed container at temperatures between 2\u00b0C and 25\u00b0C (refrigerated storage recommended for maximum lifecycle shelf-life). Keep away from direct sunlight, moisture, and localized heat sources.<\/li>\n<li>Shelf Life: 12 months from the date of manufacture when stored strictly in compliance with recommended conditions.<\/li>\n<\/ul>\n<h2>6. REGULATORY &amp; SAFETY PROFILE<\/h2>\n<p>Safety Assessment: Non-irritating to human skin (0.0% irritation index in patch testing). Non-phototoxic, non-sensitizing, and free from genetically modified organisms (GMO-free).<\/p>\n<p>Compliance: INCI registered components. Globally compliant with EU, US FDA, and China NMPA safety technical standards for cosmetics.<\/p>\n<p><img src=\"https:\/\/picx.zhimg.com\/80\/v2-e23d9ff3e08406b89a6ed2ba5f539959_720w.png\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/pica.zhimg.com\/v2-e23d9ff3e08406b89a6ed2ba5f539959.png\" data-watermark-src=\"https:\/\/picx.zhimg.com\/v2-6ceac7fbbc30412642e4fef9a0015526.png\" data-private-watermark-src=\"\" \/><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1268 -->\n\n\t\n\t\t\n<article id=\"post-1266\" class=\"post-1266 post type-post status-publish format-standard hentry category-oil-control category-platform-technology tag-anti-dermatitis tag-anti-inflammatory tag-luojia-health-forum\">\n\n\t\n\t<div class=\"entry-main\">\n\n\t\t\n\t\t<header class=\"entry-header\">\n\t\t\t\n\t\t\t<h1 class=\"entry-title\"><a href=\"http:\/\/www.puriactives.com\/en\/?p=1266\" title=\"Permalink to Product Introduction: PuriActives\u00ae Ceramide E\" rel=\"bookmark\">Product Introduction: PuriActives\u00ae Ceramide E<\/a><\/h1>\n\n\t\t\t\t\t\t\t<div class=\"entry-meta\">\n\t\t\t\t\tPosted on <a href=\"http:\/\/www.puriactives.com\/en\/?p=1266\" title=\"22:23\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2026-05-29T22:23:21+08:00\">05\/29\/2026<\/time><\/a><time class=\"updated\" datetime=\"2026-05-29T22:23:21+08:00\">05\/29\/2026<\/time> <span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" href=\"http:\/\/www.puriactives.com\/en\/?author=2\" title=\"View all posts by L, Y\" rel=\"author\">L, Y<\/a><\/span><\/span> \t\t\t\t<\/div><!-- .entry-meta -->\n\t\t\t\n\t\t<\/header><!-- .entry-header -->\n\n\t\t\t\t\t<div class=\"entry-content\">\n\t\t\t\t<p>Product Introduction: PuriActives\u00ae Ceramide E<\/p>\n<p>Advanced Biomimetic Lipid for Intensive Skin Barrier Restoration<\/p>\n<p><b>1. Executive Overview: The Next Generation of Dermocosmetics<\/b><\/p>\n<p>PuriActives\u00ae Ceramide E (INCI: Cetyl-PG Hydroxyethyl Palmitamide) represents a breakthrough in biomimetic lipid technology. Engineered specifically for the premium skincare and clinical dermocosmetics market, this high-purity pseudo-ceramide precisely replicates the structural geometry and biological function of human Ceramide Type 2.<\/p>\n<p>By acting as the ultimate &#8220;intercellular cement,&#8221; it effectively fortifies the stratum corneum, restoring the skin&#8217;s primary defense system against modern environmental stressors.<\/p>\n<p><b>2. The Science of Biomimicry: Mechanism of Action<\/b><\/p>\n<p>Natural ceramides are easily depleted by aging, harsh surfactants, and environmental factors, leading to compromised skin barriers (e.g., Atopic Dermatitis, extreme dryness).<\/p>\n<p>PuriActives\u00ae Ceramide E resolves this through advanced structural homology:<\/p>\n<ul>\n<li>Intercalation: Its optimized molecular weight and lipophilic tail allow it to seamlessly intercalate into the existing lipid matrix of the skin.<\/li>\n<li>TEWL Reduction: It physically seals the micro-fissures in the stratum corneum, dramatically reducing Transepidermal Water Loss (TEWL) and locking in endogenous moisture.<\/li>\n<li>Barrier Reinforcement: Protects sensitive nerve endings from external irritants, instantly soothing reactive skin.<\/li>\n<\/ul>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-3c852e4603c74cd75681517c5d3b97c5~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780064696-0-0-bb9832042d6418d90913ebf7adde157a&amp;bizSceneCode=article_draft&amp;expiration=1780064696&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"720\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-3c852e4603c74cd75681517c5d3b97c5~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780067954&amp;auth_key=1780067954-0-0-353e57c2b89ef711141183e9d7a68eda&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2043818608883762000\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-be8cf3828797fbfd1ef22dfe68e4fd69~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780067955&amp;auth_key=1780067955-0-0-e4789ea0ef38ce6a7db02a68c8d7c3c2&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p><b>3. The Thermodynamic Advantage: Lamellar Phases<\/b><\/p>\n<p>Beyond mere occlusion, PuriActives\u00ae Ceramide E is distinguished by its thermodynamic behavior in cosmetic formulations.<\/p>\n<p>When co-emulsified with physiological lipids (cholesterol and free fatty acids), it self-assembles into highly ordered Liquid Crystalline Lamellar Phases.<\/p>\n<ul>\n<li>Sustained Release: This multi-layered structure mimics healthy human sebum, offering long-lasting, sustained hydration rather than a temporary surface coating.<\/li>\n<li>Elegant Skin-Feel: It delivers rich, intensive moisturization without the heavy, greasy tackiness traditionally associated with heavy ointments.<\/li>\n<\/ul>\n<p><b>4. Formulation Excellence: The &#8220;Golden Ratio&#8221;<\/b><\/p>\n<p>To unlock the maximum clinical efficacy of PuriActives\u00ae Ceramide E, our scientists recommend the biomimetic 3:1:1 Ratio (Ceramide : Cholesterol : Free Fatty Acid).<\/p>\n<p>Application Versatility:<\/p>\n<ul>\n<li>Face &amp; Body Care: Barrier repair creams, anti-aging moisturizers, and soothing lotions for sensitive\/eczema-prone skin (Use Level: 0.1% &#8211; 3.0%).<\/li>\n<li>Advanced Hair Care: Deep conditioning masks and post-chemical treatment (bleaching\/coloring) cuticle lipid replenishment.<\/li>\n<li>Baby Care: Ultra-gentle, skin-identical protection for developing skin barriers.<\/li>\n<\/ul>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-a40efb56cfaaf2043debf54c1c651a32~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1780064697-0-0-e69846ea75629f8de26a2376b2fa25d7&amp;bizSceneCode=article_draft&amp;expiration=1780064697&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"720\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-a40efb56cfaaf2043debf54c1c651a32~resize:0:q75.png?source=1f5c5e47&amp;expiration=1780067954&amp;auth_key=1780067954-0-0-890b6eb57668e4bb77e81f62412c9542&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False&amp;draft_token=2043818608883762000\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-c8bfd7f1ff4a62b5af2bdc556e3031e5~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1780067955&amp;auth_key=1780067955-0-0-348e143c8296ca813afdba9dbc91c738&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p><b>5. Premium Quality &amp; &#8220;Clean Label&#8221; Promise<\/b><\/p>\n<p>Manufactured under the rigorous quality control standards of PuriPharm, this ingredient is designed for formulators targeting the &#8220;Clean Beauty&#8221; and high-end clinical segments.<\/p>\n<ul>\n<li>100% Preservative &amp; Antioxidant Free: Eliminates the risk of sensitization from additive chemicals.<\/li>\n<li>Exceptional Purity: Heavy metals meticulously controlled (\u226410mg\/kg), ensuring safety for the most sensitive dermatological applications.<\/li>\n<li>Microbiological Superiority: Meets and exceeds stringent pharmacopeial-grade limits (Aerobic Plate Count \u22641000 CFU\/g).<\/li>\n<li>Proven Stability: Guaranteed shelf life of 36 months at room temperature (4~25\u2103), demonstrating robust chemical stability.<\/li>\n<\/ul>\n<p><i>PuriPharm Co., Ltd. \u2013 Innovating at the intersection of biotechnology and dermatological science. Contact our technical team for custom formulation guidance and clinical data dossiers.<\/i><\/p>\n<p><img src=\"https:\/\/pica.zhimg.com\/80\/v2-e23d9ff3e08406b89a6ed2ba5f539959_720w.png\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"608\" data-watermark=\"original\" data-original-src=\"https:\/\/picx.zhimg.com\/v2-e23d9ff3e08406b89a6ed2ba5f539959.png\" data-watermark-src=\"https:\/\/pica.zhimg.com\/v2-6ceac7fbbc30412642e4fef9a0015526.png\" data-private-watermark-src=\"\" \/><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div><!-- .entry-content -->\n\t\t\n\t\t\n\t<\/div>\n\n<\/article><!-- #post-1266 -->\n\n\t\n\t\t<nav id=\"nav-below\" class=\"site-navigation paging-navigation\">\n\t\t<h2 class=\"assistive-text\">Post navigation<\/h2>\n\n\t\n\t\t<div class='pagination'><span aria-current=\"page\" class=\"page-numbers current\">1<\/span>\n<a class=\"page-numbers\" href=\"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fpages%2F857&#038;paged=2\">2<\/a>\n<a class=\"page-numbers\" href=\"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fpages%2F857&#038;paged=3\">3<\/a>\n<a class=\"page-numbers\" href=\"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fpages%2F857&#038;paged=4\">4<\/a>\n<a class=\"page-numbers\" href=\"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fpages%2F857&#038;paged=5\">5<\/a>\n<a class=\"page-numbers\" href=\"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fpages%2F857&#038;paged=6\">6<\/a>\n<span class=\"page-numbers dots\">&hellip;<\/span>\n<a class=\"page-numbers\" href=\"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fpages%2F857&#038;paged=11\">11<\/a>\n<a class=\"next page-numbers\" href=\"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fpages%2F857&#038;paged=2\">\u4e0b\u4e00\u9875 &raquo;<\/a><\/div>\n\n\t\n\t<\/nav><!-- #nav-below -->\n\t\n<\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/pages\/857"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=857"}],"version-history":[{"count":4,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/pages\/857\/revisions"}],"predecessor-version":[{"id":860,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/pages\/857\/revisions\/860"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}