<\/p>\n
\u221a Anit-acne: quickly and significantly reduce spots<\/p>\n
- \n
- Reduce 50% of spots or rashes within 2 weeks<\/li>\n<\/ul>\n
\u221a Preservative activity: improve the efficacy of parabens or completely replace them<\/p>\n
\u221a High security<\/p>\n
\u221a Compliant with Japanese Quasi Drugsto be used in anti-acne products<\/p>\n
![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/07\/pionin-300x178.jpg\")
<\/p>\nAnti-acne, whitening, anti-freckle<\/p>\n
Highly efficient molecule in anti-bacteria & anti-melanin<\/strong><\/p>\n
![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/07\/pan1212-300x127.jpg\")
<\/p>\nPIONIN \u00ae<\/sub><\/strong> similar to cyanine dyes. Even a single PIONIN \u00ae<\/sub><\/strong> molecule also has anti-bacterial activity, which is the reason why\u00a0 PIONIN \u00ae<\/sub><\/strong> is still efficient even with an extremely low dose:<\/p>\n
- \n
- resistant to propionibacterium acnes and inhibits melanin production.<\/li>\n
- improves the corrosion resistance of finished products<\/li>\n<\/ul>\n
![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/07\/pionn3.png\")
<\/p>\nBy causing collapse of cell membrane and cell wall and intracelluar degradation, PIONIN\u00ae<\/sub><\/strong> will damage the microorganisms.<\/p>\n
Inhibits bacteria and fungi with an extremely low dose of use (<\/em> In vitro test )<\/em><\/strong><\/p>\n
In vitro test (see table below, agar plate dilution) proves that the extremely low dose of use of PIONIN \u00ae<\/sub><\/strong> can also inhibit a wide range of bacteria and fungi. The lowest concentration of PIONIN \u00ae<\/sub><\/strong> used to inhibit bacterial growth is called the Minimum Inhibitory Concentration (MIC).<\/p>\n
\n\n
\n Bacterial names (<\/strong> Unfinished )<\/strong><\/td>\n MIC %<\/strong><\/td>\n<\/tr>\n \n Liquid achromobacter sp<\/td>\n 0.001<\/td>\n<\/tr>\n \n Enterobacteriaceae<\/td>\n 0.01<\/td>\n<\/tr>\n \n Botulinum toxin<\/td>\n 0.005<\/td>\n<\/tr>\n \n Escherichia coli<\/td>\n 0.01<\/td>\n<\/tr>\n \n Brown flavobacterium<\/td>\n 0.001<\/td>\n<\/tr>\n \n Proteusbacillus vulgaris<\/td>\n 0.001<\/td>\n<\/tr>\n \n Pseudomonas aeruginosa<\/td>\n 0.1<\/td>\n<\/tr>\n \n Salmonella enteritidis<\/td>\n 0.005<\/td>\n<\/tr>\n \n Staphylococcus aureus<\/td>\n 0.0005<\/td>\n<\/tr>\n \n Staphylococcus citrate<\/td>\n 0.001<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n
\n\n
\n Fungi names ( Unfinished )<\/strong><\/td>\n MIC %<\/strong><\/td>\n<\/tr>\n \n Absidia orchidis<\/td>\n 0.0001<\/td>\n<\/tr>\n \n Tinea capitis fungus<\/td>\n 0.001<\/td>\n<\/tr>\n \n Black aspergillus<\/td>\n 0.005<\/td>\n<\/tr>\n \n Aspergillus flavus<\/td>\n 0.0005<\/td>\n<\/tr>\n \n Candida albicans<\/td>\n 0.001<\/td>\n<\/tr>\n \n Epidermophyton floccosum<\/td>\n 0.0001<\/td>\n<\/tr>\n \n Gypsum-like microsporum<\/td>\n 0.0001<\/td>\n<\/tr>\n \n Soft rot rhizopus nigricans<\/td>\n 0.001<\/td>\n<\/tr>\n \n Saccharomyces sake<\/td>\n 0.001<\/td>\n<\/tr>\n \n Zygosaccharomyces<\/td>\n 0.0005<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n
Strong inhibition of melanin<\/strong><\/p>\n
PIONIN \u00ae<\/strong> can prevent the formation of melanin. In vitro test indicates that:<\/p>\n
- \n
- 0.000003% PIONIN \u00ae<\/strong> can suppress 50% melanin formation<\/li>\n
- 0.00001% PIONIN \u00ae<\/strong> can suppress 83% melanin formation.<\/li>\n<\/ul>\n
In contrast, 0.07% kojic acid can inhibit 100% melanin formation.<\/p>\n
![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/07\/pionn4-300x179.png\")
<\/p>\nHighly safe and non-irritant<\/strong><\/p>\n
- \n
- Human body patch test ( human body, 0.2%, 48 \u00a0hours ): negative<\/li>\n
- Initial skin irritation ( rabbit, 0.2%, 24 \u00a0hours ): negative<\/li>\n
- Sustained skin irritation ( rabbit, 0.01%, 90 \u00a0day ):negative<\/li>\n
- Eye irritation ( rabbit, 0.0007%, 24 \u00a0hour ): negative<\/li>\n
- Skin sensitization ( Guinea pig, 0.2%, maximum test ):\u00a0 negative<\/li>\n
- Phototoxicity ( rabbit, 0.2%): negative<\/li>\n
- Photosensitization ( Guinea Pig, 0.2%, Adjuvant-Strip Method ): negative<\/li>\n
- Induced gene mutation (10\u03bcg, Ames test, \u00b1S9 mix): negative<\/li>\n
- Acute Toxicity LD 50 ( mouse )\uff1a325 mg\/kg<\/li>\n<\/ul>\n
Fast & deep effect on anti-acne<\/strong><\/p>\n
![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/07\/pionn5.png\")
<\/p>\nClinical Test: Within two weeks, it reduced 50% spots<\/strong><\/p>\n
Testing program: Carry out test in 38 testees with acne problems
\nMethod: Wash face 3 times every day with emulsion containing 0.001% of PIONIN and smears twice a week with cream containing 0.005% of PIONIN.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/07\/pionn6-300x208.png\")
<\/p>\nBactericidal activity : PIONIN can be used as a preservative<\/strong><\/p>\n
The PIONIN \u00ae’s bactericidal ability allows it to be used as a preservative. In vitro test data shows that in term of anti-bacteria and anti-fungi of various kinds, PIONIN \u00ae is more effective than paraben methyl ester. Therefore, just adding a small amount of paraben in the formulation containing PIONIN \u00ae is enough to achieve an antibacterial effect.<\/p>\n
![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/07\/pionn7.jpg\")
<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/07\/pionn8.jpg\")
<\/p>\nApplication : Aniti-acne, anti-freckle, whitening, cleansing<\/strong>
\n\u2022 Anti-acne, oily skin, anti-freckle
\n\u2022 Whitening
\n\u2022 Cleaning formula, hand cream<\/p>\nDefinition<\/strong>
\n\u2022 Commodity names : PIONIN \u00ae
\n\u2022 English name : BIOXYNE
\n\u2022 INCI name : Quaternary Ammonium Salt -73
\n\u2022 China INCI (2007): has been included
\n\u2022 China INCI (2010): has been included
\n\u2022 CAS#: 15763-48-1
\n\u2022 EINECS#: 239-852-5
\n\u2022 Related regulations : Compliant with Japanese Quasi-drugs for using in acne products.<\/p>\nFormula Guidelines<\/strong><\/p>\n
\n\n
\n Dose of use<\/td>\n 0.001%~0.005%<\/strong><\/td>\n<\/tr>\n \n Suitable pH<\/strong><\/td>\n 5.5 – 8<\/strong><\/td>\n<\/tr>\n \n Solubility<\/td>\n butylene glycol \uff0cpropylene glycol\uff0cethanol\uff0c1<\/strong>\uff0c<\/strong>2<\/strong>– pentanediol<\/td>\n<\/tr>\n \n Thermal Stability<\/td>\n Up to 90 \u00b0C<\/strong><\/td>\n<\/tr>\n \n Operation Guide<\/td>\n Since PIONIN is slightly soluble in water, we recommend dissolving it in ethylene glycol and ethanol before adding the formula. It is recommended to keep the solvent in the boiling water and at the same time stir and mix them when dissolving PIONIN.<\/td>\n<\/tr>\n \n Photostability<\/td>\n Unstable; cosmetic products containing PIONIN need to be canned in opaque containers.<\/td>\n<\/tr>\n \n Existing Information<\/td>\n Overview, technical materials, PPT, technical indicators, MSDS<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n
Technical indicators<\/strong><\/p>\n
\n\n
\n Appearance<\/td>\n Crystal powder<\/td>\n<\/tr>\n \n Colour<\/td>\n Light yellow to yellow<\/td>\n<\/tr>\n \n Odor<\/td>\n Odorless<\/td>\n<\/tr>\n \n Purity (HPLC)<\/td>\n > 97%<\/td>\n<\/tr>\n \n Maximum absorption<\/td>\n 411 +\/- 2 nm<\/td>\n<\/tr>\n \n Melting point<\/td>\n 224 – 228 \u00b0 C<\/td>\n<\/tr>\n \n Loss on drying (90\u2103\uff0c3 hours )<\/td>\n < 0.5%<\/td>\n<\/tr>\n \n Ash<\/td>\n < 0.2%<\/td>\n<\/tr>\n \n Arsenic<\/td>\n < 2 ppm<\/td>\n<\/tr>\n \n Heavy metal (Pb)<\/td>\n < 10 ppm<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Storage<\/strong><\/p>\n
\n\n
\n Sample Specifications<\/td>\n 0.1g<\/td>\n<\/tr>\n \n Packaging<\/td>\n 5g<\/td>\n<\/tr>\n \n Quality guaranteed period<\/td>\n 3 years<\/td>\n<\/tr>\n \n Storage<\/td>\n Stored in a cool, dry, dark place<\/td>\n<\/tr>\n \n Use<\/td>\n Special care is taken to prevent the powder from diffusing into the air. Wear a mask to avoid inhaling powder. After use please wash your body, hands, mouth and face thoroughly (see MSDS).<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n The information in this publication is based on accuracy and integrity. However, we do not provide any guarantee or assurance for the information given because of circumstances beyond our control. Every customer should evaluate our products according to their actual needs. The information listed above is not the same as the recommended information of our products, as it may infringe the patents of other interested parties.
\n<\/strong><\/p>\n<\/p>\n","protected":false},"excerpt":{"rendered":"
\u221a Highly efficient with very low dose of use Borad acti […]<\/p>\n","protected":false},"author":1,"featured_media":118,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[17],"tags":[24,19,20,22,21,18,23],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1"}],"version-history":[{"count":2,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1\/revisions"}],"predecessor-version":[{"id":126,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1\/revisions\/126"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/media\/118"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- 0.00001% PIONIN \u00ae<\/strong> can suppress 83% melanin formation.<\/li>\n<\/ul>\n
- 0.000003% PIONIN \u00ae<\/strong> can suppress 50% melanin formation<\/li>\n