{"id":1117,"date":"2025-05-16T15:07:48","date_gmt":"2025-05-16T07:07:48","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=1117"},"modified":"2025-05-16T15:11:31","modified_gmt":"2025-05-16T07:11:31","slug":"%e6%b5%a6%e7%91%9e%e7%94%9f%e7%89%a9%e5%8c%bb%e8%8d%af%e6%8a%80%e6%9c%af%e6%9c%89%e9%99%90%e5%85%ac%e5%8f%b8%e4%b8%8e%e6%98%86%e6%98%8e%e5%8c%bb%e7%a7%91%e5%a4%a7%e5%ad%a6%e5%90%88%e4%bd%9c%e7%a0%94","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=1117","title":{"rendered":"PuriPharm Co. Ltd. and Kunming Medical University Collaborate to Achieve Breakthrough in Antidepressant"},"content":{"rendered":"\n<p>Press Release in English <\/p>\n\n\n\n<p>PuriPharm Co. Ltd. and Kunming Medical University Collaborate to Achieve Breakthrough in Antidepressant ResearchNovel Nano-Formulation Technology Enhances Efficacy of Tetrahydrocurcumin PuriPharm Co. Ltd. recently announced a significant research breakthrough in collaboration with Associate Professor Guo Ying\u2019s team from the Department of Pharmacology, Kunming Medical University. The study confirms that PuriPharm\u2019s proprietary nano-tetrahydrocurcumin (THCN) demonstrates superior efficacy in improving lipopolysaccharide (LPS)-induced depressive-like behaviors and neuroprotection in mice compared to traditional tetrahydrocurcumin (THC). The findings were published in\u00a0Acta Universitatis Medicinalis Anhui. Research Highlights \u00b7Enhanced Therapeutic Efficacy: THCN, developed using PuriPharm\u2019s advanced nano-formulation technology, showed superior anti-anxiety effects in long-term administration compared to THC. \u00b7Dual Neuroprotective Mechanisms: THCN alleviated prefrontal cortex demyelination by promoting GFAP expression, while THC mainly exerted its effects through TLR4 pathway inhibition. \u00b7Improved Stability and Bioavailability: The nano-formulation optimized drug delivery, enabling sustained efficacy at a lower dose (10 mg\/kg), a critical step toward clinical translation. Technology Value and Collaboration PuriPharm\u2019s nano-formulation platform addresses challenges such as poor solubility and low stability of natural compounds. This collaboration underscores the potential of interdisciplinary research in advancing novel antidepressant therapies. \u201cOur partnership highlights the power of industry-academia collaboration,\u201d said Associate Professor Guo Ying. \u201cTHCN offers a promising new approach for depression treatment, and we look forward to further clinical development.\u201d About PuriPharm Co. Ltd. PuriPharm specializes in nanomedicine and innovative drug delivery systems, committed to translating cutting-edge science into clinical solutions. With a focus on oncology and neurological disorders, the company leverages its expertise in nanotechnology to develop next-generation therapeutics. Media Contact PuriPharm Co. Ltd.\u00a0 Email:\u00a0service@puripharm.com Website:\u00a0www.puriactives.com<\/p>\n\n\n<div>You need to add a widget, row, or prebuilt layout before you&#8217;ll see anything here. \ud83d\ude42<\/div>","protected":false},"excerpt":{"rendered":"<p>Press Release in English PuriPharm Co. Ltd. and Kunming [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1117"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1117"}],"version-history":[{"count":4,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1117\/revisions"}],"predecessor-version":[{"id":1123,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1117\/revisions\/1123"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1117"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1117"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}