{"id":1209,"date":"2026-04-17T22:57:07","date_gmt":"2026-04-17T14:57:07","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=1209"},"modified":"2026-04-17T22:57:07","modified_gmt":"2026-04-17T14:57:07","slug":"nanoactive-r-retinoate-product-data-sheet","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=1209","title":{"rendered":"NanoActive r-RETINOATE PRODUCT DATA SHEET"},"content":{"rendered":"

PRODUCT DATA SHEET<\/h2>\n

Product Name: <\/b>NanoActive r-RETINOATE<\/p>\n

Manufacturer: <\/b>PuriPharm Co., Ltd.<\/p>\n

Awards: <\/b>2019 Ringier Technology Innovation Award (Personal Care)<\/p>\n

1. Product Overview<\/h2>\n

NanoActive r-RETINOATE<\/b>is a next-generation, high-performance Vitamin A derivative engineered to overcome the traditional limitations of retinoid application in cosmetic science. Utilizing a proprietary 20\u201330 nm nano-encapsulation delivery system, this bioactive ingredient combines exceptional anti-aging efficacy with unprecedented stability and skin tolerability.<\/p>\n

Formed by esterifying the hydroxyl group of retinol with retinoic acid, Retinyl Retinoate retains the bioactivity of both precursor molecules. It delivers up to 8x the activity of standard retinol while eliminating the characteristic irritation and photosensitivity. Crucially, its distinctive blue-light absorption profile and high photostability make it a breakthrough retinoid that is completely safe and effective for daytime application.<\/p>\n

<\/p>\n

2. Chemical Description & Composition<\/h2>\n
    \n
  • INCI Name: Retinyl Retinoate, Ascorbic Acid (Vitamin C), Phospholipids, Caprylic\/Capric Triglyceride, Glycerin, Water<\/li>\n
  • Product Type: Nano-encapsulated Bioactive System<\/li>\n
  • Active Concentration: Available in 1.0% or 5.0% Retinyl Retinoate specifications<\/li>\n<\/ul>\n

    3. Physical & Chemical Properties<\/h2>\n
      \n
    • Appearance: Yellow-orange viscous liquid<\/li>\n
    • Odor: Characteristic<\/li>\n
    • pH Value: 5.0 \u2013 8.0<\/li>\n
    • Solubility: Amphiphilic (compatible with both water and oil phases)<\/li>\n
    • Photostability: Excellent (not light-sensitive; suitable for day-care formulations)<\/li>\n<\/ul>\n

      4. Platform Technology & Delivery System<\/h2>\n

      PuriPharm’s advanced nano-delivery platform transforms how retinoids interact with the skin structure:<\/p>\n

        \n
      • Targeted Follicular Absorption: The 20\u201330 nm particle size allows the nanocarriers to accumulate efficiently within the hair follicle pathway. This creates a deep-skin “follicular reservoir” where actives can be retained rather than merely remaining on the skin’s surface.<\/li>\n
      • Sustained Release Kinetics: Once deposited in the appendages, the nano-emulsion structure facilitates a controlled, slow-release mechanism that extends the activity window for more than 10 days, ensuring long-lasting efficacy without overwhelming the skin barrier.<\/li>\n
      • Unique Occlusion Effect: Nano-sized lipid carriers create a highly uniform, tight surface film, increasing residence time and local deposition of the active compound.<\/li>\n<\/ul>\n

        5. Mechanism of Action: The One-Step Advantage<\/h2>\n

        Traditional retinol formulations require a slow, three-step metabolic conversion (Retinyl Esters \u2192 Retinol \u2192 Retinal \u2192 Retinoic Acid) to become biologically active.<\/p>\n

        NanoActive r-RETINOATE features a direct “One-Step Conversion.”<\/b>As a direct precursor, it is highly efficient and minimizes intermediate degradation.<\/p>\n

        Biocompatibility & Cytotoxicity:<\/p>\n

        In vitro data demonstrates that Retinyl Retinoate possesses significantly lower cytotoxicity compared to standard retinol. The IC50 of retinol is 25 \u03bcM, whereas the IC50 of NanoActive r-RETINOATE is 40 \u03bcM (an approximately 60% improvement in cellular tolerability), showcasing its ability to provide intense rejuvenation without the peeling, erythema, and barrier compromise associated with traditional Vitamin A.<\/p>\n

        6. Proven Cosmetic Benefits & Efficacy Data<\/h2>\n

        A. Profound Anti-Aging & UV Repair (12-Week Clinical Study)<\/h2>\n

        A controlled clinical trial comparing 0.06% Retinyl Retinoate (Group A) against 0.075% Retinol (Group B) applied twice daily demonstrated superior anti-aging performance:<\/p>\n

          \n
        • Elasticity Improvement: 90.9% of Group A subjects reported noticeable periocular elasticity improvement (vs. 81.8% in Group B).<\/li>\n
        • Photodamage Reversal: Group A exhibited an 8.61% measurable improvement in photodamage repair (vs. 7.43% in Group B).<\/li>\n
        • Longevity of Efficacy: NanoActive r-RETINOATE showed a significantly weaker “diminishing marginal effect,” meaning anti-wrinkle benefits continued to compound and remain highly visible even over long-term (1 year+) usage.<\/li>\n<\/ul>\n

          B. Hyaluronic Acid (HA) Expression<\/h2>\n

          In vivotesting on epidermal and dermal tissues (HABP staining) confirms that NanoActive r-RETINOATE significantly upregulates endogenous mucopolysaccharide (hyaluronic acid) synthesis, heavily outperforming both standard retinol and retinoic acid.<\/p>\n

          C. Multi-Pathway Skin Enhancement<\/h2>\n
            \n
          • Structural Integrity: Inhibits UV-induced Matrix Metalloproteinases (MMP) activity, reducing the breakdown of endogenous proteins, protecting elastic fibers, and promoting collagen synthesis.<\/li>\n
          • Tone & Clarity: Works synergistically with its Vitamin C component to inhibit tyrosinase, accelerate melanin metabolism, and reduce visible redness.<\/li>\n
          • Texture & Blemishes: Promotes healthy keratinocyte activity, increases epidermal thickness, and functions via multiple mechanisms to clear blemishes and accelerate the repair of acne marks.<\/li>\n<\/ul>\n

            <\/p>\n

            7. Formulation Guidance<\/h2>\n

            NanoActive r-RETINOATE is engineered for formulation elegance and versatility:<\/p>\n

              \n
            • Recommended Use Level: 1.0% \u2013 5.0%<\/li>\n
            • Optimum pH Range: 3.0 \u2013 6.5<\/li>\n
            • Processing: Simple to formulate. Add to the system at the final stage of manufacturing (post-emulsification, during the cooling phase) to protect the nanostructure.<\/li>\n
            • Compatibility: Highly compatible with a wide range of cosmetic matrices. Works exceptionally well in synergy with additional Hyaluronic Acid, Vitamin C, and biocomposite polysaccharides (e.g., hydrolyzed myrtle) for accelerated wrinkle-reduction claims.<\/li>\n<\/ul>\n

              8. Recommended Applications<\/h2>\n
                \n
              • Daytime Anti-Aging Care: Day creams, lotions, and serums targeting fine lines, leveraging its unique photostability.<\/li>\n
              • Intensive Photodamage Repair: Post-sun recovery formulations and deep wrinkle repair treatments.<\/li>\n
              • Advanced Brightening: Radiance serums addressing hyperpigmentation and uneven skin tone (pairs perfectly with brightening regimens).<\/li>\n
              • Acne & Barrier Repair: Clarifying formulations aimed at treating blemishes, repairing acne marks, and thickening the epidermal layer.<\/li>\n<\/ul>\n

                Disclaimer: <\/b>This document is provided for informational and technical support purposes only, based on PuriPharm Co., Ltd. research and development data. Formulators are responsible for conducting full stability, compatibility, and safety evaluations of their finished cosmetic products. PuriPharm Co., Ltd. makes no warranties regarding the specific outcomes of end-user formulations.<\/i><\/p>\n

                <\/p>\n","protected":false},"excerpt":{"rendered":"

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