{"id":1238,"date":"2026-05-06T23:37:59","date_gmt":"2026-05-06T15:37:59","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=1238"},"modified":"2026-05-06T23:38:32","modified_gmt":"2026-05-06T15:38:32","slug":"nanoactive-dhm","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=1238","title":{"rendered":"NanoActive DHM"},"content":{"rendered":"
Scientific Breakthrough: Epigenetic Anti-AgingDeveloped byPuriPharmCo. Ltd.<\/p>\n

1. Epigenetics and Skin Aging<\/h2>\n

What is Epigenetics?<\/h2>\n

Epigenetics is the science studying how lifestyle and environmental factors influence gene expression.<\/p>\n

This process occurs without changing the underlying DNA sequence.<\/p>\n

Instead, it alters gene activity by turning genes “on” or “off” based on external stimuli.<\/p>\n

It provides a profound new target for anti-aging interventions by addressing the root causes of cellular decline.<\/p>\n

<\/p>\n

The Identical Twins Study<\/h2>\n

<\/p>\n

Primary Drivers of Skin Aging<\/h2>\n

<\/p>\n

The Process of DNA Methylation<\/h2>\n

Lifestyle and environmental factors influence gene expression primarily through DNA methylation.<\/p>\n

Methyl groups (epigenetic factors) attach to the DNA molecule.<\/p>\n

These methylation marks can activate or, more commonly in aging, improperly repress or “silence” specific genes.<\/p>\n

This makes the DNA inaccessible to the machinery that keeps cells youthful and functional.<\/p>\n

<\/p>\n

Hypermethylation and Aging<\/h2>\n

<\/p>\n

2. The DHM Breakthrough<\/h2>\n

Introducing Dihydromyricetin: The world’s first cosmetic DNA methylation inhibitor.<\/p>\n

A Global Innovation<\/h2>\n

Dihydromyricetin (DHM)\uff1a<\/p>\n

NanoActive DHM features Dihydromyricetin, globally recognized as the first cosmetic ingredient scientifically proven to inhibit DNA methylation. This represents a paradigm shift, leading a completely new direction in epigenetic anti-aging interventions.<\/p>\n

Mechanism of Action<\/h2>\n

Inhibit Methylation: DHM acts directly at the genetic level to regulate and inhibit the excessive DNA methylation patterns that accumulate over time.<\/p>\n

Reactivate Youth Genes: By removing these inhibitory methyl tags, DHM successfully reactivates silenced youth genes.<\/p>\n

Restore Vitality: This fundamentally delays cellular aging by returning skin cells to their peak functional state, rather than just treating surface symptoms.<\/p>\n

<\/p>\n

Natural Plant Source<\/h2>\n

NanoActive DHM is extracted exclusively from Ampelopsis Grossedentata, commonly known as Vine Tea.<\/p>\n

It belongs to the Vitaceae family, Ampelopsis genus.<\/p>\n

This specific plant is exceptionally rich in naturally occurring Dihydromyricetin.<\/p>\n

It provides a clean, sustainable, and highly potent botanical source for epigenetic anti-aging formulations.<\/p>\n

<\/p>\n

Cultivation & Extraction<\/h2>\n

<\/p>\n

3. Advanced Nanoliposome Technology<\/h2>\n

Nanoliposome Principles<\/h2>\n

Definition: Nanoliposomes are microscopic vesicles composed of phospholipid bilayers that perfectly mimic the human cell membrane structure.<\/p>\n

Average Size: Ranging from 10 to 50 nm, they are perfectly sized to penetrate the skin barrier effectively.<\/p>\n

Encapsulation: They possess a high drug entrapment efficiency, capable of securely encapsulating both hydrophobic and hydrophilic active ingredients like DHM.<\/p>\n

<\/p>\n

Technology Advantages<\/h2>\n

<\/p>\n

The Dual Breakthrough<\/h2>\n

<\/p>\n

4. Clinical Efficacy and Validation<\/h2>\n

DNA Methylation Impact<\/h2>\n

Reversing the Clock<\/h2>\n

Under experimental conditions (20\u00b5M DHM over 6 weeks on a skin equivalent model), DHM treatment significantly affected over 10,000 methylation sites. It successfully induced a young epidermal DNA methylation pattern, restoring youthful epigenetic characteristics.<\/p>\n

Epidermal Structure Improvement<\/h2>\n

<\/p>\n

Reactivation of Youth Genes<\/h2>\n

<\/p>\n

5. Market Application & Value<\/h2>\n

Competitive Advantage<\/h2>\n

<\/p>\n

Target Market & Applications<\/h2>\n

<\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

Scientific Breakthrough: Epigenetic Anti-AgingDeveloped […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[35,34],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1238"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1238"}],"version-history":[{"count":3,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1238\/revisions"}],"predecessor-version":[{"id":1241,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1238\/revisions\/1241"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1238"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1238"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}