{"id":1380,"date":"2026-09-03T22:25:56","date_gmt":"2026-09-03T14:25:56","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=1380"},"modified":"2026-09-03T22:25:56","modified_gmt":"2026-09-03T14:25:56","slug":"nanoactive-xantho","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=1380","title":{"rendered":"NanoActive™ Xantho\u00a0"},"content":{"rendered":"

 <\/p>\n

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PURIPHARM CO. LTD.<\/p>\n

NanoActive™ Xantho<\/b><\/p>\n

The Multi-Pathway Hop Bioactive for Skin & Scalp Longevity<\/p>\n

INCI NAME \u2014 HUMULUS LUPULUS EXTRACT<\/p>\n

Powered by PURISOME\u00ae Liposome Delivery Technology<\/p>\n

XANTHOHUMOL \u00b7 C21H22O5 \u00b7 A PRENYLATED CHALCONE FROM HUMULUS LUPULUS<\/p>\n

02 \u00b7 POSITIONING<\/b><\/p>\n

More Than a Botanical Antioxidant<\/b><\/p>\n

From Hops to High-Performance Beauty Science<\/i><\/p>\n

Xanthohumol is a prenylated chalcone naturally present in hops (Humulus lupulus L.) that connects several major biological pathways underlying visible skin aging, uneven tone, redness, blemish-prone skin and scalp stress.<\/p>\n

NanoActive™ Xantho brings this multi-pathway biology into modern cosmetic formulation through advanced liposome delivery.<\/b><\/p>\n

01\uff5cOxidative Defense:<\/b>multi-ROS and singlet-oxygen quenching capacity<\/p>\n

02\uff5cInflammation Control:<\/b>modulation of NF-\u03baB-driven inflammatory signaling<\/p>\n

03\uff5cTone Optimization:<\/b>keratinocyte\u2013melanocyte stress communication<\/p>\n

04\uff5cMatrix Preservation:<\/b>MMP and elastase inhibition, structural protein support<\/p>\n

05\uff5cBlemish Ecosystem Support:<\/b>microbial, oxidative and inflammatory balance<\/p>\n

06\uff5cScalp Homeostasis:<\/b>a healthier foundation for scalp and hair<\/p>\n

03 \u00b7 PRODUCT PROFILE<\/b><\/p>\n

NanoActive™ Xantho at a Glance<\/b><\/p>\n

A Clean Technical Profile \u2014 Confirmed Information Only<\/i><\/p>\n

Item\uff1a<\/b>Product<\/p>\n

Confirmed information\uff1a<\/b>NanoActive™ Xantho<\/p>\n

Item\uff1a<\/b>INCI name<\/p>\n

Confirmed information\uff1a<\/b>HUMULUS LUPULUS EXTRACT<\/p>\n

Item\uff1a<\/b>Botanical source<\/p>\n

Confirmed information\uff1a<\/b>Humulus lupulus L.<\/p>\n

Item\uff1a<\/b>Signature bioactive<\/p>\n

Confirmed information\uff1a<\/b>Xanthohumol<\/p>\n

Item\uff1a<\/b>Bioactive family<\/p>\n

Confirmed information\uff1a<\/b>Prenylated chalcones<\/p>\n

Item\uff1a<\/b>Technology platform<\/p>\n

Confirmed information\uff1a<\/b>NanoActive™ \u00b7 PURISOME\u00ae Liposome Delivery<\/p>\n

Item\uff1a<\/b>Application fields<\/p>\n

Confirmed information\uff1a<\/b>Skin Care + Scalp & Hair Care<\/p>\n

Core Cosmetic Positioning<\/b><\/p>\n

Antioxidant \u00b7 Soothing \u00b7 Tone-Evening \u00b7 Anti-Aging \u00b7 Blemish Care \u00b7 Scalp Care<\/p>\n

One botanical molecule. Multiple interconnected pathways of skin and scalp aging.<\/b><\/p>\n

04 \u00b7 THE MOLECULE<\/b><\/p>\n

Xanthohumol: A Distinctive Prenylated Chalcone<\/b><\/p>\n

Botanical Origin. Molecular Precision.<\/i><\/p>\n

Xanthohumol combines the radical-scavenging chemistry of a polyphenol with a prenylated molecular architecture that supports interactions with lipid-rich biological environments.<\/p>\n

<\/p>\n

Prenyl side chain: affinity for lipid-rich biological environments. Polyphenolic chalcone core: radical-scavenging chemistry.<\/p>\n

Humulus lupulus L.: the cone of the hop plant, a natural reservoir of prenylated chalcones.<\/p>\n

Reported Biological Activities<\/b><\/p>\n

Reported biological activity\uff1a<\/b>Antioxidant<\/p>\n

Description\uff1a<\/b>Multi-ROS defense<\/p>\n

Reported biological activity\uff1a<\/b>Antimicrobial<\/p>\n

Description\uff1a<\/b>Broad Gram-positive activity<\/p>\n

Reported biological activity\uff1a<\/b>Anti-inflammatory<\/p>\n

Description\uff1a<\/b>NF-\u03baB pathway modulation<\/p>\n

Reported biological activity\uff1a<\/b>Pigmentation-modulating<\/p>\n

Description\uff1a<\/b>Multi-level tone pathways<\/p>\n

Reported biological activity\uff1a<\/b>ECM-protective<\/p>\n

Description\uff1a<\/b>MMP and elastase inhibition<\/p>\n

Ko\u0142odziejczak A, et al. Int J Mol Sci. 2024;25:11938. \u00b7 Oledzka E. Int J Mol Sci. 2024;25:3398.<\/p>\n

05 \u00b7 DELIVERY SCIENCE<\/b><\/p>\n

Why Advanced Delivery Matters<\/b><\/p>\n

Great biology meets a formulation challenge: NanoActive™ technology translates a lipophilic botanical active into a formulation-friendly format.<\/p>\n

<\/p>\n

PURISOME\u00ae liposome concept\u2014xanthohumol positioned within the phospholipid bilayer<\/p>\n

Native xanthohumol\uff1a<\/b>Highly lipophilic chalcone<\/p>\n

NanoActive™ Xantho\uff1a<\/b>Liposome-based incorporation strategy<\/p>\n

Native xanthohumol\uff1a<\/b>Poor aqueous solubility<\/p>\n

NanoActive™ Xantho\uff1a<\/b>Improved dispersion concept<\/p>\n

Native xanthohumol\uff1a<\/b>Challenging dispersion in water-rich cosmetic systems<\/p>\n

NanoActive™ Xantho\uff1a<\/b>Protection within a lipid-compatible microenvironment<\/p>\n

Native xanthohumol\uff1a<\/b>Delivery depends strongly on formulation environment<\/p>\n

NanoActive™ Xantho\uff1a<\/b>Designed for modern skin and scalp formulations<\/p>\n

Native xanthohumol\uff1a<\/b>\u2014<\/p>\n

NanoActive™ Xantho\uff1a<\/b>A rational route to unlock a hydrophobic botanical active<\/p>\n

Published research has investigated xanthohumol delivery using nanoliposomes, nanoparticles, solid lipid nanoparticles, microemulsions and other nanocarrier systems. Liposome-based delivery is a rational formulation strategy for sophisticated skin and scalp care systems.<\/p>\n

Oledzka E. Int J Mol Sci. 2024;25:3398. \u00b7 Khatib N, et al. J Food Process Preserv. 2019;43:e14075. \u00b7 Harish V, et al. Pharmaceutics. 2022;14:2403.<\/p>\n

06 \u00b7 MECHANISM MAP<\/b><\/p>\n

One Active, Multiple Beauty Pathways<\/b><\/p>\n

A Systems Approach to Skin & Scalp Longevity<\/i><\/p>\n

<\/p>\n

A systems approach to skin and scalp longevity<\/p>\n

Pathway\uff1a<\/b>ROS \/ singlet oxygen<\/p>\n

Reported direction\uff1a<\/b>Quenched \u2193<\/p>\n

Pathway\uff1a<\/b>NF-\u03baB inflammatory signaling<\/p>\n

Reported direction\uff1a<\/b>Modulated \u2193<\/p>\n

Pathway\uff1a<\/b>GM-CSF \/ melanocyte activation<\/p>\n

Reported direction\uff1a<\/b>Suppressed \u2193<\/p>\n

Pathway\uff1a<\/b>MMPs + elastase<\/p>\n

Reported direction\uff1a<\/b>Inhibited \u2193<\/p>\n

Pathway\uff1a<\/b>Collagen \u00b7 elastin \u00b7 fibrillin<\/p>\n

Reported direction\uff1a<\/b>Supported \u2191<\/p>\n

Pathway\uff1a<\/b>Acne-associated microbial pressure<\/p>\n

Reported direction\uff1a<\/b>Reduced \u2193<\/p>\n

Visible Outcomes<\/b><\/p>\n

More resilient-looking skin \u00b7 reduced appearance of redness \u00b7 more even-looking tone \u00b7 firmer, smoother appearance \u00b7 blemish-prone skin support \u00b7 healthier scalp environment.<\/b><\/p>\n

07 \u00b7 ANTIOXIDANT EVIDENCE<\/b><\/p>\n

Antioxidant Performance Beyond Conventional Benchmarks<\/b><\/p>\n

Exceptional Defense Against Multiple Reactive Oxygen Species<\/i><\/p>\n

Total ORAC \u2014 Published Assay<\/b><\/p>\n

<\/p>\n

Total ORAC: xanthohumol 4.20, green tea catechin reference 4.20, vitamin C 1.40, vitamin E 0.75<\/p>\n

Xanthohumol delivered approximately 3\u00d7 the total ORAC value of vitamin C and more than 5\u00d7 that of vitamin E in this assay system.<\/b><\/p>\n

Singlet Oxygen Absorbance Capacity \u2014 SOAC<\/b><\/p>\n

SOAC sample\uff1a<\/b>Xanthohumol<\/p>\n

Vitamin E equivalents\uff1a<\/b>14.1<\/p>\n

SOAC sample\uff1a<\/b>Green tea catechin reference<\/p>\n

Vitamin E equivalents\uff1a<\/b>1.8<\/p>\n

SOAC sample\uff1a<\/b>Vitamin E<\/p>\n

Vitamin E equivalents\uff1a<\/b>1.0<\/p>\n

Why Singlet Oxygen Matters<\/b><\/p>\n

Lipid oxidation \u00b7 squalene peroxidation \u00b7 photo-oxidative stress \u00b7 inflammatory amplification \u00b7 visible aging.<\/p>\n

Yamaguchi N, Satoh-Yamaguchi K, Ono M. Phytomedicine. 2009;16:369\u2013376. DOI: 10.1016\/j.phymed.2008.12.021.<\/p>\n

08 \u00b7 INFLAMMATION CONTROL<\/b><\/p>\n

Breaking the Oxidative\u2013Inflammatory Loop<\/b><\/p>\n

Calm the Signals That Accelerate Visible Aging<\/i><\/p>\n

Xanthohumol\u2014Interrupts the Cascade<\/b><\/p>\n

Environmental \/ UV stress\u2192ROS generation\u2192TLR4 \/ MD2\u2014NF-\u03baB activation<\/p>\n

\u2192TNF-\u03b1 \u00b7 IL-1\u03b2 \u00b7 IL-6 \u00b7 IL-12 \u00b7 NO\u2192Redness \u00b7 irritation \u00b7 ECM degradation \u00b7 uneven appearance<\/p>\n

Published Evidence<\/b><\/p>\n

Suppression of NF-\u03baB-related inflammatory signaling; reduced IL-12 production; reduced nitric oxide production; modulation of TNF-\u03b1, IL-1\u03b2 and IL-6 signaling; and reduced chronic inflammatory response in experimental skin models.<\/p>\n

Designed to help move stressed skin from inflammatory reactivity toward visible equilibrium.<\/b><\/p>\n

Cho Y-C, et al. Int Immunopharmacol. 2010;10:556\u2013561. \u00b7 Philips N, et al. Anti-Inflamm Anti-Allergy Agents Med Chem. 2010;9:142\u2013149. \u00b7 Ko\u0142odziejczak A, et al. Int J Mol Sci. 2024;25:11938.<\/p>\n

09 \u00b7 TONE SCIENCE\uff5cGM-CSF<\/b><\/p>\n

Interrupting Keratinocyte-to-Melanocyte Stress Signaling<\/b><\/p>\n

GM-CSF\u2014A Distinctive Skin-Stress Target<\/i><\/p>\n

UV and chemical stress activate epidermal keratinocytes\u2192Stressed keratinocytes release GM-CSF\u2192Melanocyte activation and stress-associated pigmentation signaling<\/p>\n

Reduction of Stress-Induced GM-CSF Release\u2014In Vitro<\/b><\/p>\n

<\/p>\n

PMA-induced stress \u221248%; UVB-induced stress \u221221%<\/p>\n

Stress model\uff1a<\/b>PMA-induced stress<\/p>\n

With xanthohumol\uff1a<\/b>52% of control, a 48% reduction<\/p>\n

Positive-control context\uff1a<\/b>57% reduction<\/p>\n

Stress model\uff1a<\/b>UVB-induced stress<\/p>\n

With xanthohumol\uff1a<\/b>79% of control, a 21% reduction<\/p>\n

Positive-control context\uff1a<\/b>45% reduction<\/p>\n

Targeting the communication between stressed keratinocytes and melanocytes.<\/b><\/p>\n

Patent-reported keratinocyte data: WO2010044076.<\/p>\n

10 \u00b7 TONE SCIENCE\uff5cEX VIVO<\/b><\/p>\n

Ex Vivo Human Skin: Keeping the UV Stress Signal Near Baseline<\/b><\/p>\n

A Compelling Keratinocyte\u2013Melanocyte Story<\/i><\/p>\n

Study element\uff1a<\/b>Model<\/p>\n

Detail\uff1a<\/b>Human skin explants<\/p>\n

Study element\uff1a<\/b>Donor panel<\/p>\n

Detail\uff1a<\/b>n=6 donors<\/p>\n

Study element\uff1a<\/b>Skin phototype<\/p>\n

Detail\uff1a<\/b>Phototype III<\/p>\n

Study element\uff1a<\/b>Stress induction<\/p>\n

Detail\uff1a<\/b>UVA + UVB challenge<\/p>\n

<\/p>\n

Active melanocytes: baseline 5.6, UVAB 10.5, UVAB + xanthohumol approximately basal<\/p>\n

Endpoint\uff1a<\/b>GM-CSF release<\/p>\n

Baseline\uff1a<\/b>5.35 pg\/mL<\/p>\n

UVAB\uff1a<\/b>approximately 4\u00d7 baseline<\/p>\n

UVAB + xanthohumol\uff1a<\/b>6.95 pg\/mL<\/p>\n

Endpoint\uff1a<\/b>Active melanocytes<\/p>\n

Baseline\uff1a<\/b>5.6<\/p>\n

UVAB\uff1a<\/b>10.5<\/p>\n

UVAB + xanthohumol\uff1a<\/b>approximately basal<\/p>\n

Xanthohumol helped disconnect UV stress from melanocyte activation.<\/b><\/p>\n

Patent-reported ex vivo human skin data: WO2010044076.<\/p>\n

11 \u00b7 TONE SCIENCE\uff5cMULTI-LEVEL<\/b><\/p>\n

More Than Tyrosinase: Multi-Level Tone Optimization<\/b><\/p>\n

Target Pigmentation Across the Epidermal Signaling Network<\/i><\/p>\n

01\uff5cSignal\u2014GM-CSF stress-signal control:<\/b>reduced keratinocyte-driven melanocyte activation following UV stress<\/p>\n

02\uff5cSynthesis\u2014melanogenic enzyme modulation:<\/b>published mushroom tyrosinase studies demonstrate potent inhibition of L-tyrosine and L-DOPA oxidation<\/p>\n

03\uff5cTransfer\u2014reduced melanocyte dendricity:<\/b>reported decrease in dendrite number and length, potentially reducing pigment transfer<\/p>\n

04\uff5cClearance\u2014melanosome clearance:<\/b>published cell studies indicate enhanced melanosome degradation in keratinocytes<\/p>\n

From pigment signaling to pigment transfer and clearance\u2014a multi-level approach to visible tone uniformity.<\/b><\/p>\n

Goenka S, Simon SR. Biochem Biophys Rep. 2021;26:100955. \u00b7 Ko\u0142odziejczak A, et al. Int J Mol Sci. 2024;25:11938. \u00b7 WO2010044076.<\/p>\n

12 \u00b7 HUMAN EVIDENCE<\/b><\/p>\n

Human Use Data: Visible Tone Evening in 8 Weeks<\/b><\/p>\n

Patent-Reported Human Cosmetic Study<\/i><\/p>\n

Study Design<\/b><\/p>\n

25 female subjects; mean age 34.1 \u00b1 6.1 years; phototypes III\u2013IV; twice-daily application for 8 weeks; test cream containing 3% P1 xanthohumol preparation, equivalent to 22.5 ppm xanthohumol. Measurements included L*, ITA\u00b0, redness a* and pigmented-spot morphology.<\/p>\n

Result\uff1a<\/b>Objective brightness \/ ITA\u00b0 criteria<\/p>\n

Finding\uff1a<\/b>68\u201372% of subjects demonstrated improvement after 8 weeks<\/p>\n

Result\uff1a<\/b>Pigmented spot area<\/p>\n

Finding\uff1a<\/b>\u221212.6% after 8 weeks<\/p>\n

Result\uff1a<\/b>Visible redness<\/p>\n

Finding\uff1a<\/b>Significantly reduced after 8 weeks<\/p>\n

Visible tone uniformity backed by human cosmetic-use data.<\/b><\/p>\n

Patent-reported human-use data: WO2010044076. Not proprietary NanoActive™ Xantho clinical testing.<\/p>\n

13 \u00b7 MATRIX LONGEVITY<\/b><\/p>\n

Defending the Youthful Extracellular Matrix<\/b><\/p>\n

Protect What Gives Skin Its Strength and Elasticity<\/i><\/p>\n

Matrix Synthesis \u21cc Matrix Degradation<\/b><\/p>\n

Slows degradation\uff1a<\/b>Inhibits MMP-1, MMP-2, MMP-8, MMP-9 and elastase<\/p>\n

Supports structural renewal\uff1a<\/b>Published fibroblast data report increased biosynthesis of collagen I, III and V, elastin, fibrillin-1 and fibrillin-2<\/p>\n

Slows degradation\uff1a<\/b>MMP-1 inhibition: 91% at 100 \u00b5g\/mL MMP-8 inhibition: 99% at 100 \u00b5g\/mL<\/p>\n

Supports structural renewal\uff1a<\/b>Structural proteins associated with skin strength and elasticity<\/p>\n

Slows degradation\uff1a<\/b>Reported IC50: MMP-1 20.5 \u00b5g\/mL; MMP-8 16.8 \u00b5g\/mL<\/p>\n

Supports structural renewal\uff1a<\/b>\u2014<\/p>\n

Dual-action matrix strategy\u2014slow degradation while supporting structural renewal.<\/b><\/p>\n

Yamaguchi N, et al. Phytomedicine. 2009;16:369\u2013376. \u00b7 Philips N, et al. J Cosmet Sci. 2010;61:125\u2013132.<\/p>\n

14 \u00b7 BLEMISH CARE<\/b><\/p>\n

A Multi-Target Active for Blemish-Prone Skin<\/b><\/p>\n

Beyond Antibacterial: Rebalancing the Blemish Ecosystem<\/i><\/p>\n

Target\uff1a<\/b>Microbial pressure<\/p>\n

Direction\uff1a<\/b>Acne-associated bacteria \u2193<\/p>\n

Target\uff1a<\/b>Oxidative stress<\/p>\n

Direction\uff1a<\/b>ROS and singlet oxygen \u2193<\/p>\n

Target\uff1a<\/b>Inflammatory signaling<\/p>\n

Direction\uff1a<\/b>COX-2 \/ PGE2 \/ IL-1\u03b2 \/ TNF-\u03b1-associated pathways \u2193<\/p>\n

Target\uff1a<\/b>Matrix stress<\/p>\n

Direction\uff1a<\/b>MMP-driven collagen degradation \u2193<\/p>\n

Published MIC Values\u2014\u00b5g\/mL<\/b><\/p>\n

<\/p>\n

MIC values: C. acnes 3 \u00b5g\/mL; S. aureus 1; S. epidermidis 3; S. pyogenes 1<\/p>\n

Organism\uff1a<\/b>C. acnes<\/p>\n

Published MIC, \u00b5g\/mL\uff1a<\/b>3<\/p>\n

Organism\uff1a<\/b>S. aureus<\/p>\n

Published MIC, \u00b5g\/mL\uff1a<\/b>1<\/p>\n

Organism\uff1a<\/b>S. epidermidis<\/p>\n

Published MIC, \u00b5g\/mL\uff1a<\/b>3<\/p>\n

Organism\uff1a<\/b>S. pyogenes<\/p>\n

Published MIC, \u00b5g\/mL\uff1a<\/b>1<\/p>\n

Cutibacterium acnes was reported as Propionibacterium acnes in the original study.<\/p>\n

Antioxidant + antimicrobial + inflammation-modulating + matrix-protective activity in one botanical platform.<\/b><\/p>\n

Yamaguchi N, et al. Phytomedicine. 2009;16:369\u2013376.<\/p>\n

15 \u00b7 SCALP & HAIR CARE<\/b><\/p>\n

Scalp-First Hair Care<\/b><\/p>\n

Healthy-Looking Hair Starts with Scalp Homeostasis<\/i><\/p>\n

<\/p>\n

Scalp and follicular microenvironment\u2014oxidative, sebum and microbial stress signals<\/p>\n

01\uff5cOxidative-Stress Defense:<\/b>helps counter environmental and photo-oxidative stress affecting the scalp<\/p>\n

02\uff5cScalp Comfort:<\/b>supports modulation of inflammatory signaling associated with visible redness and discomfort<\/p>\n

03\uff5cSebum Environment Support:<\/b>hop and xanthohumol literature supports sebum-conscious cosmetic concepts<\/p>\n

04\uff5cMicrobial-Balance-Oriented Care:<\/b>broad activity against relevant Gram-positive microorganisms supports scalp-purifying concepts<\/p>\n

05\uff5cFollicular Environment Protection:<\/b>helps maintain a healthier biochemical environment around the scalp and follicular opening<\/p>\n

A scalp-first active for stronger skin foundations and healthier-looking hair.<\/b><\/p>\n

WO2010044076 describes topical xanthohumol applications for improving the overall condition of skin and scalp.<\/p>\n

16 \u00b7 APPLICATIONS<\/b><\/p>\n

Formulation & Application Opportunities<\/b><\/p>\n

From High-Performance Facial Care to Advanced Scalp Systems<\/i><\/p>\n

Skin Care\uff1a<\/b>Antioxidant serums; tone-evening essences; anti-aging concentrates<\/p>\n

Scalp & Hair Care\uff1a<\/b>Scalp serums; scalp tonics; scalp essences<\/p>\n

Skin Care\uff1a<\/b>Blemish-prone skin serums; post-stress soothing products; redness-care formulations<\/p>\n

Scalp & Hair Care\uff1a<\/b>Sebum-conscious scalp care; sensitive-scalp formulas; anti-pollution scalp care<\/p>\n

Skin Care\uff1a<\/b>Urban defense \/ anti-pollution care; after-sun skin care<\/p>\n

Scalp & Hair Care\uff1a<\/b>Premium shampoos; conditioners; leave-on scalp treatments<\/p>\n

Skin Care\uff1a<\/b>Eye and facial care; premium night-repair products<\/p>\n

Scalp & Hair Care\uff1a<\/b>Hair-density appearance support concepts*<\/p>\n

*Based on scalp health.<\/p>\n

Suitable for development across sophisticated leave-on and rinse-off skin and scalp formats.<\/b><\/p>\n

17 \u00b7 THE NANOACTIVE™ XANTHO ADVANTAGE<\/b><\/p>\n

One Active. Six Strategic Beauty Territories.<\/b><\/p>\n

01\uff5cAntioxidant Shield:<\/b>multi-ROS and singlet-oxygen defense<\/p>\n

02\uff5cRedness & Comfort:<\/b>multi-pathway inflammatory-signaling modulation<\/p>\n

03\uff5cEven-Tone Science:<\/b>GM-CSF, melanocyte activation, pigment transport and melanosome pathways<\/p>\n

04\uff5cMatrix Longevity:<\/b>MMP \/ elastase inhibition plus structural-protein support<\/p>\n

05\uff5cBlemish Ecosystem:<\/b>antimicrobial, antioxidant, inflammatory and matrix approach<\/p>\n

06\uff5cScalp Homeostasis:<\/b>oxidative, inflammatory, sebum and microbial-environment support<\/p>\n

Multi-Pathway Botanical Intelligence, Delivered by Liposome Science.<\/b><\/p>\n

NanoActive™ Xantho transforms the biological versatility of hop-derived xanthohumol into a modern active platform for next-generation skin and scalp care.<\/p>\n

18 \u00b7 EVIDENCE BASE<\/b><\/p>\n

Selected Scientific References<\/b><\/p>\n

Human & Ex Vivo Evidence \u00b7 Primary Mechanistic Data \u00b7 High-Quality Reviews<\/i><\/p>\n

01\uff5c<\/b>Yamaguchi N, Satoh-Yamaguchi K, Ono M. In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components addressing acne vulgaris.Phytomedicine.<\/i>2009;16:369\u2013376. DOI: 10.1016\/j.phymed.2008.12.021.<\/p>\n

02\uff5c<\/b>Philips N, Samuel M, Arena R, et al. Direct inhibition of elastase and matrix metalloproteinases and stimulation of biosynthesis of fibrillar collagens, elastin, and fibrillins by xanthohumol.J Cosmet Sci.<\/i>2010;61:125\u2013132.<\/p>\n

03\uff5c<\/b>Cho YC, You SK, Kim HJ, et al. Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis.Int Immunopharmacol.<\/i>2010;10:556\u2013561.<\/p>\n

04\uff5c<\/b>Goenka S, Simon SR. Depigmenting effect of xanthohumol from hop extract in MNT-1 human melanoma cells and normal human melanocytes.Biochem Biophys Rep.<\/i>2021;26:100955.<\/p>\n

05\uff5c<\/b>Ko\u0142odziejczak A, Dziedzic M, Algiert-Zieli\u0144ska B, et al. A Novel Look at Mechanisms and Applications of Xanthohumol in Dermatology and Cosmetology.Int J Mol Sci.<\/i>2024;25:11938. DOI: 10.3390\/ijms252211938.<\/p>\n

06\uff5c<\/b>Oledzka E. Xanthohumol\u2014A Miracle Molecule with Biological Activities: A Review of Biodegradable Polymeric Carriers and Naturally Derived Compounds for Its Delivery.Int J Mol Sci.<\/i>2024;25:3398. DOI: 10.3390\/ijms25063398.<\/p>\n

07\uff5c<\/b>Gerh\u00e4user C. Broad spectrum antiinfective potential of xanthohumol from hop in comparison with activities of other hop constituents and metabolites.Mol Nutr Food Res.<\/i>2005;49:827\u2013831.<\/p>\n

08\uff5c<\/b>WO2010044076. Cosmetic and topical uses of xanthohumol, including skin brightening, reduction of skin redness and GM-CSF-related mechanisms.<\/p>\n

Evidence hierarchy: human \/ ex vivo cosmetic evidence \u2192 primary peer-reviewed mechanistic data \u2192 high-quality scientific reviews.<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

  PURIPHARM CO. LTD. NanoActive™ Xantho The […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1380"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1380"}],"version-history":[{"count":1,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1380\/revisions"}],"predecessor-version":[{"id":1381,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1380\/revisions\/1381"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1380"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}