{"id":1394,"date":"2026-09-17T21:06:07","date_gmt":"2026-09-17T13:06:07","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=1394"},"modified":"2026-09-17T21:06:07","modified_gmt":"2026-09-17T13:06:07","slug":"nanoactive-sa-3","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=1394","title":{"rendered":"NanoActive™ SA"},"content":{"rendered":"

NanoActive™ SA Nano-encapsulated Salicylic Acid<\/h2>\n

Precision purification, from pores to scalp<\/p>\n

NEXT-GENERATION SALICYLIC ACID DELIVERY<\/b><\/p>\n

NanoActive™ SA | Nano-encapsulated Salicylic Acid<\/h2>\n

<\/p>\n

Precision purification, from pores to scalp<\/b><\/p>\n

Powered by PURISOME\u00ae FlexVes™ Liposome Technology<\/p>\n

INCI:<\/b> Salicylic Acid<\/p>\n

POSITIONING<\/b><\/p>\n

Proven salicylic acid efficacy \u00d7 advanced nanoliposomal delivery<\/h2>\n

NanoActive™ SA combines the well-established biological value of salicylic acid with PuriPharm\u2019s proprietary nano-delivery platform, offering a more formulation-friendly, skin-compatible and targeted solution for modern cosmetic formulations.<\/p>\n

Classic salicylic acid, scientifically validated<\/b><\/p>\n

Keratin renewal and normalized desquamationComedolytic action and follicular decongestionSebum and blemish management<\/p>\n

PURISOME\u00ae nanoliposomal delivery<\/b><\/p>\n

Water-phase friendlyControlled, sustained deliveryPotential for follicular targeting<\/p>\n

Face care \u00b7 Body care \u00b7 Scalp and hair care<\/b><\/p>\n

MODERN SKIN & SCALP CHALLENGES<\/b><\/p>\n

Oily skin and scalp: persistent, recurring concerns<\/h2>\n

Recurring concerns<\/b><\/p>\n

01 Visibly enlarged pores02 Excess keratin buildup03 Blackheads and whiteheads04 Rough, uneven texture05 Shine and dullness06 Recurrent pore congestion07 Scalp oil and adherent flakes<\/p>\n

What determines the appearance of visible pores?<\/b><\/p>\n

Keratin buildup within folliclesLevel of sebum productionStructural visibility of follicular openingsSkin surface texture<\/p>\n

Pore appearance = keratin \u00d7 sebum \u00d7 structure \u00d7 texture<\/b><\/p>\n

Pore concerns are multifactorial. This limits purely astringent approaches and provides a clear scientific entry point for actives that manage keratinization.<\/p>\n

THE CLASSIC ACTIVE<\/b><\/p>\n

Salicylic acid: an enduring classic in skin science<\/h2>\n

<\/p>\n

Salicylic Acid \u00b7 C\u2087H\u2086O\u2083<\/p>\n

INCI:<\/b> Salicylic AcidType:<\/b> aromatic hydroxy acid (BHA), pKa \u2248 3.0Properties:<\/b> lipophilic, with affinity for sebum-rich and follicular environments; limited solubility in water at room temperature.<\/p>\n

01 Aromatic hydroxy-acid structure<\/b><\/p>\n

The benzene ring and ortho hydroxyl and carboxyl groups determine its distinctive physicochemical behavior.<\/p>\n

02 Lipophilicity<\/b><\/p>\n

Unlike water-soluble AHAs, it can enter sebum-rich follicular environments.<\/p>\n

03 Affinity for the pilosebaceous unit<\/b><\/p>\n

It can act where comedones and blemishes originate.<\/p>\n

04 Activity within the stratum corneum<\/b><\/p>\n

It acts on connections between corneocytes without requiring deep penetration.<\/p>\n

Its molecular properties give salicylic acid a distinctive role in pore and follicular care.<\/p>\n

MECHANISM 01 \u00b7 DESMOLYTIC ACTION<\/b><\/p>\n

Mechanism 1: desmolysis regulates cohesion rather than \u201cdissolving keratin\u201d<\/h2>\n

Modern skin science holds that salicylic acid disrupts intercellular connections and reduces corneocyte cohesion, allowing abnormally accumulated keratin to shed in an orderly manner rather than simply \u201cdissolving keratin.\u201d<\/p>\n

Densely accumulated stratum corneum<\/b><\/p>\n

\u2193<\/p>\n

Reduced corneocyte cohesion<\/b><\/p>\n

\u2193<\/p>\n

Normalized desquamation<\/b><\/p>\n

\u2193<\/p>\n

Smoother skin surface<\/b><\/p>\n

Formulation relevance:<\/b> Desmolysis rather than aggressive peeling supports keratin management with a lower burden. This biology underpins applications for oily skin, pores, blemishes and the scalp.<\/p>\n

MECHANISM 02 \u00b7 COMEDOLYTIC ACTION<\/b><\/p>\n

Mechanism 2: comedolytic action along the follicular pathway<\/h2>\n

Comedone formation cascade<\/b><\/p>\n

Hyperkeratinization<\/b><\/p>\n

\u2193<\/p>\n

Follicular opening blockage<\/b><\/p>\n

\u2193<\/p>\n

Microcomedone<\/b><\/p>\n

\u2193<\/p>\n

Blackhead \/ whitehead<\/b><\/p>\n

\u2193<\/p>\n

Inflammatory lesion<\/b><\/p>\n

\u2460 Normalized desquamation<\/b><\/p>\n

Corrects hyperkeratinization at the follicular opening and reduces blockage at its source.<\/p>\n

\u2461 Lipophilic penetration<\/b><\/p>\n

Moves through the sebum-rich environment into the follicle instead of remaining on the surface.<\/p>\n

\u2462 Reduced cellular buildup<\/b><\/p>\n

Decreases abnormal accumulation of keratinocytes within the follicle.<\/p>\n

\u2463 Comedolysis<\/b><\/p>\n

Helps clear established blockages and improve blackheads and whiteheads.<\/p>\n

Effective comedone management depends on keratinization within the follicle, not only surface cleansing. Salicylic acid\u2019s lipophilicity gives it this distinctive position.<\/p>\n

Mechanism review: Arif T. Clin Cosmet Investig Dermatol.<\/i> 2015;8:455\u2013461.<\/p>\n

MECHANISM 03 \u00b7 INFLAMMATION & BLEMISH BIOLOGY<\/b><\/p>\n

Mechanism 3: the inflammatory dimension of acne biology<\/h2>\n

Inflammation is present throughout acne development, including the invisible microcomedone stage. Blemish care therefore should not begin only after lesions become visible.<\/p>\n

Published literature reports that salicylic acid modulates multiple inflammation-related pathways, including arachidonic-acid metabolism and inflammatory signaling. Together with its desmolytic and comedolytic actions, this supports both purification and stabilization.<\/p>\n

Sebum production + abnormal keratinization<\/b><\/p>\n

\u2193<\/p>\n

Changed follicular microenvironment<\/b><\/p>\n

\u2193<\/p>\n

Microbial involvement<\/b><\/p>\n

\u2193<\/p>\n

Amplified inflammatory cascade<\/b><\/p>\n

\u2193<\/p>\n

Erythema, papules and post-acne marks<\/b><\/p>\n

Salicylic acid intervenes at several upstream points:<\/b> keratinization, the follicular environment and inflammation.<\/p>\n

These mechanism-level statements reflect literature consensus and explain ingredient-level biological relevance. They do not constitute pharmaceutical treatment claims.<\/p>\n

Mechanism review: Arif T. Clin Cosmet Investig Dermatol.<\/i> 2015;8:455\u2013461.<\/p>\n

CLINICAL EVIDENCE 01 \u00b7 ASIAN ACNE STUDY<\/b><\/p>\n

30% salicylic acid peel: a 12-week study in Asian patients with acne<\/h2>\n

35<\/b><\/p>\n

Asian participants<\/p>\n

Mild to moderate<\/b><\/p>\n

Facial acne<\/p>\n

30%<\/b><\/p>\n

Salicylic acid peel<\/p>\n

Every 2 weeks<\/b><\/p>\n

One treatment<\/p>\n

12 weeks<\/b><\/p>\n

Observation period<\/p>\n

77.1%<\/b><\/p>\n

Reported moderate or good improvement<\/p>\n

    \n
  • Significant reduction in inflammatory lesions<\/li>\n
  • Significant reduction in non-inflammatory lesions<\/li>\n
  • Significant decrease in overall acne severity<\/li>\n
  • No statistically significant worsening in stratum-corneum hydration, surface lipids, skin pH or TEWL<\/li>\n<\/ul>\n

    Lee HS, Kim IH. Salicylic acid peels for the treatment of acne vulgaris in Asian patients. Dermatol Surg.<\/i> 2003;29:1196\u20131199.<\/p>\n

    This is published clinical evidence for salicylic acid, not a finished-product efficacy trial of NanoActive™ SA.<\/p>\n

    CLINICAL EVIDENCE 02 \u00b7 COMEDONE COUNT<\/b><\/p>\n

    Mean facial comedone count fell by approximately 75% over 10 weeks<\/h2>\n

    <\/p>\n

    Statistical significance<\/b><\/p>\n

    p = 0.001<\/p>\n

    Study information<\/b><\/p>\n

    Participants: 16 Japanese patientsSystem: 30% salicylic acid in PEGFrequency: once every 2 weeksDuration: 10 weeks<\/p>\n

    Mean count decreased from 39.3 at baseline to 9.2 at Week 10, with continued improvement throughout follow-up.<\/p>\n

    Hashimoto Y, et al. Salicylic acid peels in polyethylene glycol vehicle for the treatment of comedogenic acne in Japanese patients. Dermatol Surg.<\/i> 2008;34:276\u2013279.<\/p>\n

    Published evidence for a 30% salicylic acid\u2013PEG peel, not a finished-product efficacy trial of NanoActive™ SA.<\/p>\n

    POST-ACNE MARKS \u00b7 UNEVEN TONE<\/b><\/p>\n

    From acne to post-acne marks: a framework for managing pigmentation<\/h2>\n

    How salicylic acid can improve uneven tone<\/b><\/p>\n

    \u2460 Normalize exfoliation: accelerate surface renewal<\/b><\/p>\n

    \u2193<\/p>\n

    \u2461 Remove pigment-containing corneocytes: lift superficial deposited pigment<\/b><\/p>\n

    \u2193<\/p>\n

    \u2462 Improve acne-related inflammation: reduce conditions that promote new marks<\/b><\/p>\n

    \u2193<\/p>\n

    A more even-looking skin tone<\/b><\/p>\n

    Salicylic acid is not a tyrosinase inhibitor. Its tone-related value comes from the combined effects of keratin renewal and inflammation management, not direct inhibition of melanin synthesis.<\/p>\n

    Comparative clinical evidence<\/b><\/p>\n

    30% salicylic acid vs 30% glycolic acidMild-to-moderate acne with post-inflammatory hyperpigmentation (PIH)<\/p>\n

    Study findings<\/b><\/p>\n

    Both peel regimens improved PIH; the salicylic acid group showed better tolerability in this study; relevant to combined acne and post-acne-mark concerns.<\/p>\n

    The literature also documents salicylic acid use in superficial peels for melasma and photo-induced uneven tone.<\/p>\n

    Reference: Arif T. Clin Cosmet Investig Dermatol.<\/i> 2015;8:455\u2013461.<\/p>\n

    TEXTURE & PHOTOAGING<\/b><\/p>\n

    Beyond blemish care: keratin renewal and younger-looking texture<\/h2>\n

    Controlled keratin renewal can address not only blemishes, but also surface features associated with aging and photodamage:<\/p>\n

      \n
    • Roughness and grainy texture<\/li>\n
    • Dullness and loss of radiance<\/li>\n
    • Fine surface lines<\/li>\n
    • Uneven texture<\/li>\n
    • Visible signs of photoaging<\/li>\n<\/ul>\n

      <\/p>\n

      Change from baseline with a sodium salicylate formulation<\/p>\n

      Evidence boundary:<\/b> The study tested a sodium salicylate formulation, not free salicylic acid. Histology also indicated increases in fibrillin and procollagen I. The findings support salicylate\/exfoliation biology and are not direct clinical evidence for NanoActive™ SA.<\/p>\n

      Merinville E, et al. Three clinical studies showing the anti-aging benefits of sodium salicylate in human skin. J Cosmet Dermatol.<\/i> 2010;9:174\u2013184. Wrinkle depth and skin roughness decreased significantly at Weeks 4 and 8.<\/p>\n

      THE FORMULATION PARADOX<\/b><\/p>\n

      The challenge with salicylic acid is delivery, not efficacy<\/h2>\n

      Salicylic acid has limited solubility in water at room temperature. Traditional clear aqueous products often rely on ethanol, glycols, surfactant solubilization, partial neutralization and precise pH management, creating a persistent trade-off between efficacy and formulation elegance.<\/p>\n

      Traditional free-salicylic-acid formulation pathway<\/b><\/p>\n

      Salicylic acid powder<\/b><\/p>\n

      \u2193<\/p>\n

      Solvent system<\/b><\/p>\n

      \u2193<\/p>\n

      Partial neutralization<\/b><\/p>\n

      \u2193<\/p>\n

      pH adjustment<\/b><\/p>\n

      \u2193<\/p>\n

      Trade-offs in crystallization, irritation and sensory profile<\/b><\/p>\n

      Each step solves one problem while introducing another compromise.<\/p>\n

      NanoActive™ SA technology pathway<\/b><\/p>\n

      NanoActive™ SA<\/b><\/p>\n

      \u2193<\/p>\n

      Pre-engineered nano-delivery<\/b><\/p>\n

      \u2193<\/p>\n

      Easy incorporation into the aqueous phase<\/b><\/p>\n

      \u2193<\/p>\n

      Controlled active delivery \u00b7 formulation freedom<\/b><\/p>\n

      The carrier addresses solubility so formulators regain design flexibility. Delivery technology is the dividing line in modernizing salicylic acid.<\/p>\n

      FREE ACID & pH<\/b><\/p>\n

      The free-acid state determines effective delivery<\/h2>\n

      Salicylic Acid \u21cc Salicylate\u2212 + H+<\/b><\/p>\n

      Molecular form (free acid)\u3000\u3000Ionic form (salicylate)<\/p>\n

      pH < pKa<\/b><\/p>\n

      Free acid predominates, with a greater tendency to penetrate.<\/p>\n

      pKa \u2248 3.0<\/b><\/p>\n

      Key reference point for the ionization equilibrium.<\/p>\n

      pH > pKa<\/b><\/p>\n

      The salt form predominates, increasing water solubility.<\/p>\n

      01 Molecular and ionic forms<\/b><\/p>\n

      They differ in solubility, partition coefficient and skin penetration.<\/p>\n

      02 pH determines equilibrium<\/b><\/p>\n

      Small pH adjustments can change the free-acid fraction in the same formulation.<\/p>\n

      03 Carrier and pH jointly affect penetration<\/b><\/p>\n

      The formulation itself is part of salicylic acid performance.<\/p>\n

      04 Cost of conventional neutralization<\/b><\/p>\n

      Higher water solubility comes with a changed effective free-acid fraction.<\/p>\n

      PURISOME\u00ae Technology proposition:<\/b> A nanocarrier environment supports effective salicylic acid delivery while improving formulation compatibility and reducing reliance on high solvent levels and complex neutralization strategies.<\/p>\n

      THE PURIPHARM RESPONSE<\/b><\/p>\n

      NanoActive™ SA: PuriPharm\u2019s technology response<\/h2>\n

      NanoActive™ SA<\/b>Nano-encapsulated salicylic acidINCI: Salicylic AcidPowered by PURISOME\u00ae FlexVes™ Liposome Technology<\/p>\n

      Maintains an effective free-acid state<\/b><\/p>\n

      The carrier environment protects the effective form of salicylic acid.<\/p>\n

      Aqueous formulation compatibility<\/b><\/p>\n

      Disperses stably and incorporates easily into aqueous systems.<\/p>\n

      Potential for clear formulations<\/b><\/p>\n

      Supports modern formats such as clear serums and gels.<\/p>\n

      Reduced solvent dependence<\/b><\/p>\n

      Reduces the need for large amounts of ethanol or polyols.<\/p>\n

      Controlled delivery<\/b><\/p>\n

      Gradual release produces more even exposure.<\/p>\n

      Improved skin comfort<\/b><\/p>\n

      A sustained-release approach supports a better user experience.<\/p>\n

      Potential for follicular targeting<\/b><\/p>\n

      Follicular reservoir effect and localized enrichment.<\/p>\n

      Face and scalp applications<\/b><\/p>\n

      One platform supports multiple use cases.<\/p>\n

      This is a redesigned delivery pathway for salicylic acid, not merely salicylic acid placed inside a carrier.<\/p>\n

      THE TECHNOLOGY PLATFORM<\/b><\/p>\n

      PURISOME\u00ae FlexVes™ Liposome Technology<\/h2>\n

      PuriPharm\u2019s proprietary advanced nanoliposomal platform uses skin-compatible phospholipid bilayer vesicles.<\/p>\n

      <\/p>\n

      Cross-sectional schematic: amphiphilic phospholipids self-assemble into a bilayer that encapsulates or associates with the active.<\/p>\n

      01 Improved formulation compatibility<\/b><\/p>\n

      A water-dispersed format bypasses the solubility bottleneck.<\/p>\n

      02 Controlled, sustained release<\/b><\/p>\n

      Carrier association releases the active gradually through interfacial processes.<\/p>\n

      03 Lower potential for localized irritation<\/b><\/p>\n

      Avoids sudden skin contact with a high concentration of free acid.<\/p>\n

      04 Improved deposition and delivery<\/b><\/p>\n

      Skin-compatible lipids promote active deposition in the target region.<\/p>\n

      Hereafter referred to as PURISOME\u00ae Technology. Its four delivery advantages support the same goal: bringing the active to the intended site at an appropriate rate.<\/p>\n

      DELIVERY MECHANISM<\/b><\/p>\n

      PURISOME\u00ae FlexVes™: a redesigned salicylic acid delivery pathway<\/h2>\n

      <\/p>\n

      Schematic: larger particles remain on the surface because they cannot pass through intercellular gaps, while smaller nanocarriers can move along these gaps and release the active.<\/p>\n

      01 Interaction with stratum-corneum lipids<\/b><\/p>\n

      Skin-compatible phospholipids approach intercellular lipids.<\/p>\n

      02 Gradual release<\/b><\/p>\n

      The active is progressively released from the carrier interface.<\/p>\n

      03 Follicular deposition<\/b><\/p>\n

      The carrier moves along the follicular pathway and enriches the target region.<\/p>\n

      Nanoscale delivery \u00b7 skin-compatible lipids \u00b7 controlled release \u00b7 improved compatibility \u00b7 follicular-delivery potential \u00b7 better sensory profile<\/b><\/p>\n

      The schematic follows standard pharmaceutics models of phospholipid bilayer vesicle interactions with skin.<\/p>\n

      FOLLICULAR TARGETING<\/b><\/p>\n

      Follicular targeting and the follicular-reservoir concept<\/h2>\n

      <\/p>\n

      Nanoparticles vs free drug: a, stratum-corneum surface; b, enrichment in the follicular infundibulum; c, migration deeper along the follicle.<\/p>\n

      <\/p>\n

      Particles deposit in the follicular infundibulum and diffuse into surrounding tissue.<\/p>\n

      Follicular targeting \u00b7 follicular reservoir \u00b7 localized enrichment<\/b><\/p>\n

        \n
      • Blackheads and comedones<\/li>\n
      • Oily pores<\/li>\n
      • Scalp buildup<\/li>\n
      • Keratin buildup within follicles<\/li>\n<\/ul>\n

        Statements about follicular targeting and reservoirs are based on the PURISOME\u00ae Technology platform\u2019s delivery concept and are consistent with existing NanoActive™ platform data.<\/p>\n

        Left image adapted from Prow TW, et al. Nanoparticles and microparticles for skin drug delivery. Adv Drug Deliv Rev.<\/i> 2011;63:470\u2013491.<\/p>\n

        CONTROLLED RELEASE & SKIN COMFORT<\/b><\/p>\n

        From concentration peaks to gradual release<\/h2>\n

        Traditional free salicylic acid<\/b><\/p>\n

        <\/p>\n

        Rapid local exposure produces a concentration peak, with potential stinging and irritation.<\/p>\n

        NanoActive™ SA<\/b><\/p>\n

        <\/p>\n

        Carrier-associated delivery supports gradual release, more even local exposure and potential for improved comfort.<\/p>\n

        <\/p>\n

        Nanocarrier occlusion effect<\/b>Smaller particles and a higher number of carriers per unit area can form a denser lipid film on the skin surface. This may improve stratum-corneum hydration, promote active penetration and reduce water loss, adding another mechanistic basis for efficacy with comfort.<\/p>\n

        FOR FORMULATORS<\/b><\/p>\n

        Making salicylic acid easier to formulate and use<\/h2>\n
          \n
        1. Easy incorporation and process-friendly handling<\/li>\n
        2. Suitable for aqueous systems<\/li>\n
        3. Potential for transparent and clear formulations<\/li>\n
        4. Reduced dependence on high ethanol levels<\/li>\n
        5. Less need for aggressive solubilization strategies<\/li>\n
        6. Compatible with serums, gels, cleansers and scalp formats<\/li>\n
        7. Can be added at low temperature, depending on the process<\/li>\n<\/ol>\n\n\n\n\n\n\n
          Process and compatibility guidance<\/th>\nDetails<\/th>\n<\/tr>\n
          Suggested use level<\/td>\nApproximately 1\u20135%<\/td>\n<\/tr>\n
          Addition method<\/td>\nAdd at low temperature<\/td>\n<\/tr>\n
          Compatibility note<\/td>\nAvoid combining with divalent or trivalent metal ions<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

          Based on historical PuriPharm technical materials. If this information differs from the latest product TDS, follow the current TDS.<\/p>\n

          Formulation freedom is itself a product advantage.<\/p>\n

          APPLICATION MAP<\/b><\/p>\n

          One application map, from face to scalp<\/h2>\n

          FACE<\/b><\/p>\n

          Anti-acne serumPore-refining serumKeratin-regulating tonerCleanserClear gelMoisturizer for oily skinBlemish care<\/p>\n

          BODY<\/b><\/p>\n

          Body acne sprays and lotionsKeratosis pilaris careExfoliating body washCare for rough areas<\/p>\n

          SCALP & HAIR<\/b><\/p>\n

          Anti-dandruff shampooShampoo for oily scalpScalp serumScalp exfoliating treatmentScalp-cleansing products<\/p>\n

          One technology platform supports three major application areas: face, body and scalp.<\/p>\n

          SCALP & HAIR 01 \u00b7 SCALP BIOLOGY<\/b><\/p>\n

          From facial pores to scalp follicles<\/h2>\n

          Persistent scalp concerns<\/b><\/p>\n

          01 Scalp keratin buildup02 Excess scalp oil03 Adherent flakes04 Buildup at follicular openings05 Scalp cleanliness and freshness06 Disrupted scalp-renewal rhythm<\/p>\n

          Why salicylic acid suits scalp care<\/b><\/p>\n

          Desmolytic action:<\/b> softens and removes corneocytes adhering to the scalp surface.Reduced surface buildup:<\/b> addresses adherent layers formed by oil and keratin.Clearer follicular openings:<\/b> lipophilicity supports entry along the sebum-rich environment.Improved appearance of oily scalp:<\/b> a fresher scalp and lighter-feeling roots.<\/p>\n

          Scalp follicles present a problem structurally analogous to facial pores. Scalp care is another application of the same keratin biology, not merely an extension of facial care.<\/p>\n

          SCALP & HAIR 02 \u00b7 DANDRUFF CARE<\/b><\/p>\n

          Scalp purification and dandruff care<\/h2>\n

          Biology of dandruff<\/b><\/p>\n

          Dandruff is associated with abnormal desquamation of the stratum corneum.Malassezia<\/i> plays an important role in dandruff biology.Effective management should address flake control, microbial factors and overall scalp condition.<\/p>\n

          Scalp positioning of NanoActive™ SA<\/b><\/p>\n

          \u2460 Desmolytic scalp active\u2461 Scalp-flake removal\u2462 Oily-scalp care\u2463 Follicular cleansing\u2464 Supporting ingredient in anti-dandruff shampoo systems<\/p>\n

          Scientific boundary: salicylic acid should not be claimed as a standalone antifungal ingredient. In multi-ingredient anti-dandruff systems, it contributes keratin management and flake control.<\/p>\n

          Suggested formats:<\/b> anti-dandruff shampoo \u00b7 shampoo for oily scalp \u00b7 scalp serum \u00b7 scalp treatment liquid \u00b7 scalp exfoliating treatment \u00b7 pre-shampoo scalp care<\/p>\n

          Dandruff systems require multiple complementary mechanisms. NanoActive™ SA addresses the keratin and flake-control component.<\/p>\n

          COMPARISON<\/b><\/p>\n

          Traditional salicylic acid vs NanoActive™ SA<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
          Dimension<\/th>\nTraditional salicylic acid<\/th>\nNanoActive™ SA<\/th>\n<\/tr>\n
          Aqueous formulation difficulty<\/td>\nHigh: limited water solubility<\/td>\nLow: easy dispersion and incorporation in water<\/td>\n<\/tr>\n
          Crystallization risk<\/td>\nPotential precipitation and crystallization<\/td>\nCarrier encapsulation lowers risk<\/td>\n<\/tr>\n
          Solvent dependence<\/td>\nOften requires high levels of ethanol or polyols<\/td>\nDependence substantially reduced<\/td>\n<\/tr>\n
          pH management<\/td>\nPrecise control changes the free-acid fraction<\/td>\nA more flexible formulation window<\/td>\n<\/tr>\n
          Delivery profile<\/td>\nRapid release and local concentration peak<\/td>\nGradual release and more even exposure<\/td>\n<\/tr>\n
          Skin comfort<\/td>\nStinging possible at high concentration<\/td>\nSustained-release approach with comfort potential<\/td>\n<\/tr>\n
          Clear-formulation capability<\/td>\nLimited<\/td>\nSupports clear, transparent formulations<\/td>\n<\/tr>\n
          Follicular delivery<\/td>\nRelies on compensating formulation engineering<\/td>\nPotential for follicular targeting and reservoir deposition<\/td>\n<\/tr>\n
          Dosage-form flexibility<\/td>\nLimited selection<\/td>\nSerums, gels, cleansers and scalp formats<\/td>\n<\/tr>\n
          Fit for scalp applications<\/td>\nDual challenge of solubilization and irritation<\/td>\nAqueous-friendly and suited to modern scalp formats<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

          VALUE PROPOSITION<\/b><\/p>\n

          NanoActive™ SA: a four-dimensional value proposition<\/h2>\n

          EFFICACY\uff5cClassic salicylic acid, multidimensional purification<\/b><\/p>\n

          Peer-reviewed literature supports the combined mechanisms of keratin renewal, comedolysis and inflammation modulation.<\/p>\n

          DELIVERY\uff5cPURISOME\u00ae nanoliposomal delivery<\/b><\/p>\n

          Skin-compatible phospholipid bilayer vesicles carry the active and support follicular targeting and reservoir deposition.<\/p>\n

          COMFORT\uff5cSustained-release concept for a better experience<\/b><\/p>\n

          Gradual release smooths concentration peaks and troughs, adding comfort potential to efficacy.<\/p>\n

          FORMULATION\uff5cAqueous-friendly with greater design freedom<\/b><\/p>\n

          From serums to shampoos, the platform enables salicylic acid formats that were previously difficult to formulate.<\/p>\n

          Evidence for efficacy, technology for delivery, attention to experience and room for formulation.<\/p>\n

          REFERENCES<\/b><\/p>\n

          References and evidence grading<\/h2>\n

          Published literature cited in this presentation<\/b><\/p>\n

            \n
          1. Lee HS, Kim IH. Salicylic acid peels for the treatment of acne vulgaris in Asian patients. Dermatol Surg.<\/i> 2003;29:1196\u20131199.<\/li>\n
          2. Hashimoto Y, et al. Salicylic acid peels in polyethylene glycol vehicle for the treatment of comedogenic acne in Japanese patients. Dermatol Surg.<\/i> 2008;34:276\u2013279.<\/li>\n
          3. Arif T. Salicylic acid as a peeling agent: a comprehensive review. Clin Cosmet Investig Dermatol.<\/i> 2015;8:455\u2013461.<\/li>\n
          4. Merinville E, et al. Three clinical studies showing the anti-aging benefits of sodium salicylate in human skin. J Cosmet Dermatol.<\/i> 2010;9:174\u2013184.<\/li>\n<\/ol>\n

            Clinical evidence for salicylic acid<\/b><\/p>\n

            References [1] and [2]: 30% peel systems, not finished-product studies.<\/p>\n

            Evidence for a salicylate derivative<\/b><\/p>\n

            Reference [4]: sodium salicylate, supporting the biological pathway.<\/p>\n

            Mechanism and review literature<\/b><\/p>\n

            Reference [3]: exfoliation, comedolysis and skin-tone applications.<\/p>\n

            None of the published references cited here constitutes a finished-product efficacy trial of NanoActive™ SA.<\/p>\n

            NANOACTIVE™ SA<\/b><\/p>\n

            Making classic salicylic acid more suitable for next-generation formulations<\/h2>\n

            Powered by PURISOME\u00ae FlexVes™ Liposome Technology<\/p>\n

            PuriPharm Co. Ltd.<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

            NanoActive™ SA Nano-encapsulated Salicylic Acid […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1394"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1394"}],"version-history":[{"count":1,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1394\/revisions"}],"predecessor-version":[{"id":1395,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1394\/revisions\/1395"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1394"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}