{"id":1396,"date":"2026-09-17T21:46:18","date_gmt":"2026-09-17T13:46:18","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=1396"},"modified":"2026-09-17T21:46:18","modified_gmt":"2026-09-17T13:46:18","slug":"puriactives-biocalmin","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=1396","title":{"rendered":"PuriActives\u00ae BioCalmin"},"content":{"rendered":"

PuriActives\u00ae BioCalmin<\/h2>\n

Precision Molecular Soothing for Sensitive Skin & Scalp<\/p>\n

PURIPHARM CO. LTD. \u2014 COSMETIC ACTIVE INGREDIENTS<\/b><\/p>\n

PuriActives\u00ae BioCalmin<\/h2>\n

<\/p>\n

Precision Molecular Soothing for Sensitive Skin & Scalp<\/b><\/p>\n

INCI:<\/b> Hydroxyphenyl Propamidobenzoic AcidScientific name:<\/b> Dihydroavenanthramide D (DHAvD), nature-inspired synthetic avenanthramide<\/p>\n

<\/p>\n

Nature-Inspired Chemistry \u00b7 Fast Comfort \u00b7 Multi-Pathway Defense<\/b><\/p>\n

THE CHALLENGE \u2014 SKIN BIOLOGY<\/b><\/p>\n

When Skin Overreacts, Multiple Signals Converge<\/h2>\n

COMMON MANIFESTATIONS\uff1aItching\u3001Redness\u3001Burning\u3001Stinging\u3001Tightness\u3001Dryness\u3001Irritation\u3001Scalp discomfort<\/b><\/p>\n

POTENTIAL TRIGGERS\uff1aSurfactantsEnvironmental stress\u3001Dry skin\u3001Shaving\u3001Hair coloring\u3001Bleaching\u3001Exfoliating acid\u3001Retinoids\u3001Frequent cleansing\u3001Compromised skin barrier<\/b><\/p>\n

THE SIGNALING CASCADE \u2014 SCHEMATIC<\/b><\/p>\n

External Stress<\/b><\/p>\n

\u2193<\/p>\n

Sensory Nerve Activation \u00b7 Substance P<\/b><\/p>\n

\u2193<\/p>\n

Mast Cell Activation<\/b><\/p>\n

\u2193<\/p>\n

Histamine + Inflammatory Mediators<\/b><\/p>\n

\u2193<\/p>\n

Itch \u00b7 Redness \u00b7 Discomfort<\/b><\/p>\n

One trigger can set off the full neurogenic irritation chain \u2014 effective soothing starts upstream.<\/p>\n

THE MOLECULE<\/b><\/p>\n

Nature-Inspired Precision Chemistry<\/h2>\n

<\/p>\n

Dihydroavenanthramide D (DHAvD) | MW \u2248 285.3 Da | logP \u2248 3.34<\/p>\n\n\n\n\n\n\n
Item<\/th>\nInformation<\/th>\n<\/tr>\n
INCI NAME<\/td>\nHydroxyphenyl Propamidobenzoic Acid<\/td>\n<\/tr>\n
SCIENTIFIC NAME<\/td>\nDihydroavenanthramide D (DHAvD)<\/td>\n<\/tr>\n
INGREDIENT FAMILY<\/td>\nNature-inspired synthetic avenanthramide<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

A synthetic analogue nature-inspired by oat avenanthramides \u2014 the phenolic anthranilic acid amides behind the protective chemistry of oats \u2014 engineered as a highly defined molecular active with consistent, reproducible performance.<\/p>\n

Key actions<\/b><\/p>\n

Anti-itchAnti-rednessAnti-histamine pathway<\/p>\n

Product attributes<\/b><\/p>\n

AntioxidantEffective at low concentrationsSkin & scalp soothing<\/p>\n

Molecular properties per published pharmaceutical-formulation research on DHAvD. Highly defined molecular identity \u2014 not an oat extract. Activity at low concentrations, across both skin and scalp applications.<\/p>\n

DESIGN LOGIC<\/b><\/p>\n

From Oat Defense Chemistry to Targeted Cosmetic Soothing<\/h2>\n

Avenanthramides are anthranilic acid amides known for biological activities relevant to skin comfort. PuriActives\u00ae BioCalmin translates that biology into one defined, reproducible molecule.<\/p>\n

Oat Avenanthramide Biology<\/b><\/p>\n

\u2193<\/p>\n

Structure\u2013Activity Understanding<\/b><\/p>\n

\u2193<\/p>\n

Dihydroavenanthramide D<\/b><\/p>\n

\u2193<\/p>\n

Consistent Molecular Soothing Performance<\/b><\/p>\n

MOLECULAR ADVANTAGES<\/b><\/p>\n

Controlled molecular identityReproducible quality, batch after batchStrong activity at ppm-level concentrations<\/p>\n

MULTIFUNCTIONAL ADVANTAGES<\/b><\/p>\n

Multifunctional soothing profileAntioxidant capacityBroad formulation potential<\/p>\n

Nature-Inspired. Molecularly Defined.<\/b>The premium positioning \u2014 beyond \u201cnaturalness\u201d: defined, reproducible, potent.<\/p>\n

MECHANISM<\/b><\/p>\n

One Molecule. Four Levels of Skin Comfort.<\/h2>\n

NET RESULT:<\/b> Less Itch \u00b7 Less Redness \u00b7 Less Irritation \u00b7 More Comfort<\/p>\n

01 Substance P \/ Mast Cell Pathway<\/b><\/p>\n

Helps inhibit Substance P-induced histamine release from mast cells.<\/p>\n

02 Histamine-Related Itch & Redness<\/b><\/p>\n

Helps reduce downstream itch and erythema responses in challenged skin.<\/p>\n

03 Inflammatory Signaling<\/b><\/p>\n

Published mechanistic research supports modulation of NF-\u03baB-related inflammatory signaling.<\/p>\n

04 Oxidative Stress<\/b><\/p>\n

Strong radical-scavenging activity helps limit the oxidative amplification of irritation.<\/p>\n

MECHANISM IN FOCUS<\/b><\/p>\n

Interrupting the Substance P\u2013Mast Cell\u2013Histamine Axis<\/h2>\n

Sensory Nerve<\/b><\/p>\n

\u2193<\/p>\n

Substance P<\/b><\/p>\n

\u2193<\/p>\n

Mast Cell<\/b><\/p>\n

\u2193<\/p>\n

Histamine<\/b><\/p>\n

\u2193<\/p>\n

Itch \u00b7 Redness<\/b><\/p>\n

PuriActives\u00ae BioCalmin inhibits Substance P-induced histamine release.<\/p>\n

Substance P released from sensory nerves stimulates mast cells and promotes histamine release, driving itching, redness and neurogenic skin discomfort. Published studies show that synthetic avenanthramides including Dihydroavenanthramide D inhibit Substance P-induced histamine release from mast cells; the original patent literature describes anthranilic acid amides for precisely this purpose.<\/p>\n

Target the Signal Before It Becomes Visible Discomfort.<\/b><\/p>\n

Evidence type: in vitro mast-cell assay; patent literature.<\/p>\n

EVIDENCE \u2014 IN VITRO<\/b><\/p>\n

Strong Activity at ppm-Level Concentrations<\/h2>\n

<\/p>\n

\u221281%<\/b>histamine net release at 500 ppm DHAvD vs. stimulated control<\/p>\n

Published in-vitro mast-cell results show progressive, dose-dependent suppression of histamine net release as DHAvD concentration rises from 0.5 to 500 ppm \u2014 potent activity well below typical use levels.<\/p>\n

Histamine net release relative to Substance P-stimulated control (= 100%). Chart redrawn from published data.Source: Schmaus G, Herrmann M, Joppe H, Lange S, Koch O, Pillai R, R\u00f6ding J. Dihydroavenanthramide D for Anti-irritant and Anti-itch. Cosmetics & Toiletries.<\/i> 2007;122(11):55\u201366.<\/p>\n

EVIDENCE \u2014 HUMAN IN VIVO<\/b><\/p>\n

From Mast Cells to Human Skin<\/h2>\n\n\n\n\n\n\n\n\n\n
HUMAN IN VIVO \u2014 HISTAMINE CHALLENGE<\/th>\nSTUDY DESIGN<\/th>\n<\/tr>\n
Method<\/td>\nDouble-blind, placebo controlled<\/td>\n<\/tr>\n
Challenge<\/td>\nHistamine challenge (skin-prick model)<\/td>\n<\/tr>\n
Subjects<\/td>\n\u2248 10 subjects per study<\/td>\n<\/tr>\n
Formulations<\/td>\nO\/W emulsions with 500 ppm synthetic avenanthramides<\/td>\n<\/tr>\n
Controls<\/td>\nPlacebo & untreated controls<\/td>\n<\/tr>\n
Assessment<\/td>\nItch and redness scoring up to 180 minutes<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Itch Reduction<\/b><\/p>\n

<\/p>\n

significantly lower vs placebo \u2014 p < 0.05<\/p>\n

Redness Reduction<\/b><\/p>\n

<\/p>\n

significantly lower vs placebo \u2014 p < 0.05<\/p>\n

Schematic representation of the published outcome \u2014 synthetic avenanthramides including Dihydroavenanthramide D significantly reduced histamine-induced itch and redness versus placebo and untreated skin; bar heights are illustrative, not original quantitative values. Source: Schmaus G, et al. Cosmetics & Toiletries.<\/i> 2007;122(11):55\u201366.<\/p>\n

Visible Redness Down. Perceived Itch Down.<\/p>\n

POTENCY<\/b><\/p>\n

Powerful Soothing Does Not Require High Loading<\/h2>\n

500 ppm<\/p>\n

= 0.05% active<\/p>\n

The concentration that demonstrated meaningful anti-itch and anti-redness activity in the published human histamine-challenge model.<\/p>\n

High biological potency<\/b><\/p>\n

Meaningful activity at a low concentration.<\/p>\n

Efficient formulation concept<\/b><\/p>\n

Supports efficient formulation design.<\/p>\n

Attractive in sophisticated sensitive-skin formulations<\/b><\/p>\n

Suitable for advanced sensitive-skin products.<\/p>\n

Compatible with multi-active cosmetic systems<\/b><\/p>\n

Can be integrated into multi-active systems.<\/p>\n

Published active concentration for Dihydroavenanthramide D (Schmaus G, et al. 2007). Final PuriActives\u00ae BioCalmin use level and assay: refer to the current PuriPharm TDS \/ SPEC.<\/p>\n

EVIDENCE \u2014 ANTIOXIDANT<\/b><\/p>\n

Soothing + Radical Defense<\/h2>\n

ABTS ANTIOXIDANT ASSAYIC50 = 26.54 \u03bcMIC50 = 7.57 \u03bcg\/mL<\/b><\/p>\n

Published ABTS data report radical-scavenging activity for DHAvD comparable with the reference antioxidants \u03b1-tocopherol and Trolox under the same assay conditions.<\/p>\n

    \n
  • Helps neutralize reactive radicals<\/li>\n
  • Helps reduce oxidative amplification of irritation<\/li>\n
  • Supports environmental-stress protection concepts<\/li>\n
  • Complements sensitive-skin and healthy-aging formulations<\/li>\n<\/ul>\n

    Calm Today. Defend Against Tomorrow\u2019s Stress.<\/p>\n

    Source: Schmaus G, et al. Dihydroavenanthramide D for Anti-irritant and Anti-itch. Cosmetics & Toiletries.<\/i> 2007;122(11):55\u201366.<\/p>\n

    MECHANISTIC CONTEXT<\/b><\/p>\n

    Beyond Histamine: Supporting Control of the Inflammatory Cascade<\/h2>\n

    ROS \/ Cytokine Stress<\/b><\/p>\n

    \u2193<\/p>\n

    I\u03baB degradation<\/b><\/p>\n

    \u2193<\/p>\n

    NF-\u03baB Activation<\/b><\/p>\n

    \u2193<\/p>\n

    Inflammatory Mediator Expression<\/b><\/p>\n

    Published mechanistic studies on DHAvD demonstrate suppression of NF-\u03baB-related signaling and downstream iNOS \/ NO responses in experimental biological models \u2014 a second, histamine-independent layer of the molecule\u2019s soothing logic.<\/p>\n

    How to read this evidence:<\/b> Supporting mechanistic evidence \u2014 not a direct clinical skin-efficacy claim. The experimental disease model in the source publication is not a product indication.<\/p>\n

    MECHANISTIC STUDY \u2014 NF-\u03baB \u00b7 iNOS \u00b7 NOReference: Lv N, Song MY, Lee YR, et al. Biochem Biophys Res Commun.<\/i> 2009;387(1):97\u2013102.<\/p>\n

    MOLECULAR ROBUSTNESS<\/b><\/p>\n

    Stable Across a Remarkably Broad pH Window<\/h2>\n

    Broad pH stability expands formulation possibilities.<\/p>\n

    pH 3\u3000\u2014\u3000pH 5\u3000\u2014\u3000pH 7\u3000\u2014\u3000pH 9\u3000\u2014\u3000pH 12<\/p>\n

    acidicalkaline<\/p>\n

    Published stability research evaluated DHAvD at pH 3 \u00b7 5 \u00b7 7 \u00b7 9 \u00b7 12 over 24 weeks and reported only slight degradation \u2014 even under very acidic and very alkaline conditions.<\/p>\n

    24 weeks of stability evaluation<\/b><\/p>\n

    WHERE BROAD pH STABILITY MATTERS<\/b><\/p>\n

    Facial skin careCleansing productsShaving products<\/p>\n

    MORE APPLICATIONS<\/b><\/p>\n

    Scalp productsHair coloring systemsBleaching-associated comfort concepts<\/p>\n

    Molecule-level stability data (published research; Schmaus G, et al. 2007). Final product pH range and handling: current PuriPharm TDS \/ SPEC.<\/p>\n

    FORMULATION SCIENCE<\/b><\/p>\n

    Unlocking Dermal Availability Through Smart Vehicle Design<\/h2>\n

    <\/p>\n

    Vehicle design determines how much DHAvD reaches viable skin.<\/p>\n

    EX VIVO HUMAN SKIN \u2014 FRANZ DIFFUSION<\/b><\/p>\n

      \n
    • 2\u20134\u00d7 higher DHAvD release within 30 minutes with a 2% butylene glycol \/ pentylene glycol blend<\/li>\n
    • \u2248 2\u00d7 penetration into viable skin layers within 30 minutes<\/li>\n
    • Sustained delivery advantage maintained over 300 minutes<\/li>\n<\/ul>\n

      <\/p>\n

      41% vs 12% of the applied dose, optimized vs reference formulation.<\/p>\n

      Published formulation science using Dihydroavenanthramide D. Source: Heuschkel S, Wohlrab J, Schmaus G, Neubert RHH. Eur J Pharm Biopharm.<\/i> 2008;70(1):239\u2013247. doi:10.1016\/j.ejpb.2008.04.005<\/p>\n

      SCALP CARE<\/b><\/p>\n

      Sensitive Scalp Is Sensitive Skin<\/h2>\n

      <\/p>\n

      WHAT SENSITIVE SCALP FEELS LIKE<\/b><\/p>\n

      Itching \u00b7 Burning \u00b7 Redness \u00b7 Dryness \u00b7 Tightness \u00b7 Dandruff-associated discomfort \u00b7 Irritation after coloration or bleaching<\/p>\n

      WHERE BIOCALMIN FITS<\/b><\/p>\n

      Scalp soothing tonicsSensitive-scalp shampoosAnti-dandruff shampoosScalp serums<\/p>\n

      MORE APPLICATIONS<\/b><\/p>\n

      Dry-scalp treatmentsHair-color aftercareBleaching \/ perming comfortDaily scalp care<\/p>\n

      Comfort Starts at the Scalp.<\/p>\n

      EVIDENCE \u2014 CLINICAL SCALP STUDY<\/b><\/p>\n

      Noticeable Scalp Comfort in 30 Minutes<\/h2>\n

      <\/p>\n

      \u221257%<\/p>\n

      scalp itch vs. placebo<\/p>\n

      after 30 minutes \u00b7 single application \u00b7 p < 0.05<\/p>\n\n\n\n\n\n\n\n
      CLINICAL SCALP STUDY<\/th>\nInformation<\/th>\n<\/tr>\n
      Participants<\/td>\n18 volunteers with itchy scalp<\/td>\n<\/tr>\n
      Test formulation<\/td>\n1% tested same-active formulation<\/td>\n<\/tr>\n
      Design<\/td>\nSingle application, placebo controlled<\/td>\n<\/tr>\n
      Evaluation<\/td>\n30-minute evaluation<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      <\/p>\n

      Relative scalp itch (placebo = 100%).<\/p>\n

      Source: Published same-active scalp clinical study; n = 18; 30-minute single-application evaluation. Chart redrawn in the PuriPharm visual system.<\/p>\n

      EVIDENCE \u2014 CLINICAL SCALP STUDY<\/b><\/p>\n

      Immediate Comfort. Sustained Performance.<\/h2>\n

      CLINICAL SCALP STUDY \u2014 5 DAYS\u221240%<\/b> itching vs. baseline after five days\u221247%<\/b> itching vs. placebo after five days<\/p>\n

      The same study reported a marked reduction in burning sensation.<\/p>\n

      <\/p>\n

      \u221240% vs baseline<\/p>\n

      <\/p>\n

      \u221247% vs placebo<\/p>\n

      From Fast Relief to Daily Scalp Comfort<\/p>\n

      18 volunteers with itchy scalp \u00b7 once-daily use \u00b7 5-day treatment \u00b7 placebo comparison \u00b7 symptom scores for itching and burning. Published same-active scalp clinical study; charts redrawn from reported results.<\/p>\n

      SCALP CARE \u2014 COMBINATION CONCEPT<\/b><\/p>\n

      Go Beyond Flake Control<\/h2>\n

      Anti-Dandruff Active + Dihydroavenanthramide D<\/b><\/p>\n

      \u2193<\/p>\n

      Flake Management + Itch Comfort<\/b><\/p>\n

      Published patent literature reports combinations of DHAvD with climbazole for itchy scalp and anti-dandruff applications. Human studies described in the patent showed improved itch reduction when the two actives were combined \u2014 the anti-dandruff active manages flakes while DHAvD addresses the itch signal.<\/p>\n

      0.05% DHAvD + 0.2% ClimbazoleSynergy index 0.77<\/b>synergistically enhanced itch-relieving activity in the patent dataset<\/p>\n

      APPLICATIONS:<\/b> Anti-dandruff shampoo \u00b7 Anti-dandruff scalp serum \u00b7 Scalp lotion \u00b7 Itchy dry-scalp products<\/p>\n

      PATENT REFERENCES:<\/b>WO2004047833A2 \u2014 Anthranilic acid amides and derivatives thereof as cosmetic and pharmaceutical agents (2004)WO2007062957A1 \/ EP1959915B1 \/ US8911795B2 \u2014 Anthranilic acid amide + anti-dandruff active combinations for itch relief (2007)<\/p>\n

      APPLICATIONS \u2014 SKIN CARE<\/b><\/p>\n

      High-Performance Soothing Across Skin-Care Categories<\/h2>\n

      <\/p>\n

      Add Comfort Without Compromising Performance.<\/p>\n

      SENSITIVE SKIN<\/b><\/p>\n

      Sensitive-skin serumSoothing essenceRedness-care creamDaily comfort moisturizerSensitive body lotion<\/p>\n

      HIGH-ACTIVITY SKIN CARE<\/b><\/p>\n

      Retinoid companion careAHA \/ BHA \/ PHA formulationsBrightening systemsPost-exfoliation careAdvanced anti-aging formulas<\/p>\n

      STRESS & RECOVERY<\/b><\/p>\n

      After-sunAfter-shavePost-cleansing comfortDry, itchy-feeling skin careMask formulationsEnvironmental-stress products<\/p>\n

      APPLICATIONS \u2014 HAIR & SCALP<\/b><\/p>\n

      A Dedicated Soothing Strategy for Modern Scalp Care<\/h2>\n

      <\/p>\n

      APPLICATION CONCEPTS<\/b><\/p>\n

      Sensitive scalp shampooScalp soothing tonicAnti-dandruff shampooAnti-dandruff serumDry scalp care<\/p>\n

      MORE FORMATS<\/b><\/p>\n

      Scalp essencePost-hair-color carePost-bleaching comfortRelaxing \/ straightening aftercareLeave-on scalp spray<\/p>\n

      CORE BENEFIT ARCHITECTURE<\/b><\/p>\n

      Anti-ItchAnti-RednessScalp ComfortAnti-Dandruff SupportPost-Chemical-Treatment Soothing<\/p>\n

      From sensitive-skin care to advanced scalp comfort \u2014 one molecule, two territories.<\/p>\n

      WHY PURIACTIVES\u00ae BIOCALMIN<\/b><\/p>\n

      Calm the Signal. Restore the Comfort.<\/h2>\n

      <\/p>\n

      PuriActives\u00ae BioCalmin \u2014 Hydroxyphenyl Propamidobenzoic Acid. A precision molecule for next-generation soothing formulations, from sensitive-skin care to advanced scalp comfort.<\/p>\n

      FAST<\/b><\/p>\n

      Rapidly helps relieve itch and discomfort.<\/p>\n

      TARGETED<\/b><\/p>\n

      Acts on the Substance P\u2013mast cell\u2013histamine pathway.<\/p>\n

      PROVEN<\/b><\/p>\n

      Supported by human, cellular and formulation research.<\/p>\n

      MULTIFUNCTIONAL<\/b><\/p>\n

      Soothing + redness care + antioxidant defense.<\/p>\n

      VERSATILE<\/b><\/p>\n

      Designed for advanced skin and scalp concepts.<\/p>\n","protected":false},"excerpt":{"rendered":"

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