{"id":1398,"date":"2026-09-17T22:32:50","date_gmt":"2026-09-17T14:32:50","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=1398"},"modified":"2026-09-17T22:32:50","modified_gmt":"2026-09-17T14:32:50","slug":"puriactives-sodium-trehalose-sulfate-10","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=1398","title":{"rendered":"PuriActives\u00ae Sodium Trehalose Sulfate 10%"},"content":{"rendered":"

PuriActives\u00ae Sodium Trehalose Sulfate 10%<\/h2>\n

Beyond Hydration \u00b7 Barrier Biology<\/p>\n

TECHNICAL PRODUCT PRESENTATION<\/b><\/p>\n

PuriActives\u00ae Sodium Trehalose Sulfate 10%<\/h2>\n

<\/p>\n

From Hydration to Activation of the Skin\u2019s Own Moisturizing Barrier<\/b><\/p>\n

Beyond Hydration \u00b7 Barrier Biology<\/p>\n

INCI NAME:<\/b> SODIUM TREHALOSE SULFATEPuriPharm Co. Ltd.<\/p>\n

RETHINKING HYDRATION<\/b><\/p>\n

Moisturization Is More Than Adding Water to Skin<\/h2>\n

CLASSICAL MOISTURIZATION: WATER FROM OUTSIDE<\/b><\/p>\n

Humectant:<\/b> draws water from the environment or deeper layersEmollient:<\/b> softens the stratum corneum and improves skin feelOcclusive:<\/b> forms a film and reduces evaporationAll three add or retain water, but do not directly build the skin\u2019s own moisturizing system.<\/p>\n

BARRIER BIOLOGY: HELPING SKIN MANAGE WATER<\/b><\/p>\n

01 Keratinocyte differentiation and cornification02 Epidermal lipid transport (ABCA12)03 Ceramide barrier organization04 Filaggrin (FLG) metabolism05 Natural moisturizing factor (NMF) production<\/p>\n

PuriActives\u00ae Sodium Trehalose Sulfate moves from external hydration toward support for the skin\u2019s endogenous moisturizing system.<\/p>\n

PRODUCT IDENTITY<\/b><\/p>\n

PuriActives\u00ae Sodium Trehalose Sulfate 10%<\/h2>\n

<\/p>\n

Chemical structure of sodium trehalose sulfate, Maeda et al., 2024<\/p>\n\n\n\n\n\n\n\n
Item<\/th>\nInformation<\/th>\n<\/tr>\n
INCI NAME<\/td>\nSODIUM TREHALOSE SULFATE<\/td>\n<\/tr>\n
Ingredient category<\/td>\nLow-molecular-weight sulfated disaccharide active<\/td>\n<\/tr>\n
Functional positioning<\/td>\nMoisturizing active \u00b7 barrier-care active \u00b7 skin-conditioning active<\/td>\n<\/tr>\n
Molecular feature<\/td>\nMol.Wt. \u2248 694 (tri- or tetra-sulfated)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Trehalose backbone<\/b><\/p>\n

\u2193<\/p>\n

Sulfation<\/b><\/p>\n

\u2193<\/p>\n

Sodium salt<\/b><\/p>\n

Sulfation differentiates it from ordinary trehalose, transforming a sugar into a barrier-active molecule.<\/p>\n

WHY SULFATION<\/b><\/p>\n

Trehalose Is Only the Starting Point: Sulfation Changes Biological Behavior<\/h2>\n

Trehalose<\/b><\/p>\n

<\/p>\n

Sodium trehalose sulfate<\/b><\/p>\n

<\/p>\n

Key comparisons in the Maeda study<\/b><\/p>\n

    \n
  • Unsulfated trehalose did not produce the same complete barrier-gene expression response as sodium trehalose sulfate.<\/li>\n
  • In a 3D epidermal-model TEWL test, the trehalose group did not differ significantly from control, while the sodium trehalose sulfate group showed a significant reduction.<\/li>\n
  • Low-molecular-weight sulfated disaccharides below 1,000 Da can act on stratum-corneum barrier function.<\/li>\n<\/ul>\n

    <\/p>\n

    3D epidermal-model TEWL (g\/cm\u00b2\u00b7h): only the sulfated-sugar group was significantly lower than control, *p<0.05.<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666. Chemical structures reproduced from Figure 2.<\/p>\n

    THREE PILLARS OF THE BARRIER<\/b><\/p>\n

    An Effective Barrier Depends on Three Coordinated Systems<\/h2>\n

    Cornified Envelope<\/b><\/p>\n

    IVL \u00b7 TGM1<\/p>\n

    Intercellular Lipids<\/b><\/p>\n

    ABCA12 \u00b7 Ceramide<\/p>\n

    Natural Moisturizing Factors<\/b><\/p>\n

    FLG \u00b7 CASP14 \u00b7 CAPN1 \u00b7 BLMH<\/p>\n

    Sodium trehalose sulfate is supported by evidence across all three systems.<\/b>These systems determine the \u201cbricks\u201d of the stratum corneum, the \u201cmortar\u201d between them, and water storage within the bricks.<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666.<\/p>\n

    MECHANISM OVERVIEW<\/b><\/p>\n

    One Molecule, Multiple Pathways to Strengthen the Moisturizing Barrier<\/h2>\n

    After topical application, sodium trehalose sulfate participates in epidermal biological regulation:<\/p>\n

    01 IVL \/ TGM1 \u2191<\/b><\/p>\n

    Cornified-envelope formation \u2191<\/p>\n

    02 ABCA12 \u2191<\/b><\/p>\n

    Lamellar-granule lipid transport \u2191Ceramide-barrier organization \u2191<\/p>\n

    03 FLG \/ CASP14 \/ CAPN1 \/ BLMH \u2191<\/b><\/p>\n

    Free amino acids \u2191Natural moisturizing factors (NMF) \u2191<\/p>\n

    All three pathways converge on:<\/b> barrier integrity \u2191 \u00b7 stratum-corneum hydration \u2191 \u00b7 transepidermal water loss (TEWL) \u2193<\/p>\n

    Evidence chain:<\/b> qPCR gene expression \u00b7 immunofluorescence protein validation \u00b7 free-amino-acid measurement \u00b7 3D-model TEWL \u00b7 four-week double-blind human study<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666.<\/p>\n

    LIPID TRANSPORT \u00b7 ABCA12<\/b><\/p>\n

    ABCA12 Enables the Skin to Transport Its Own Barrier Lipids<\/h2>\n

    ABCA12 is a key lipid transporter in keratinocytes. This ATP-binding cassette transporter loads intracellular lipids into lamellar granules and delivers them to the stratum corneum.<\/p>\n

    Intracellular lipid synthesis<\/b><\/p>\n

    \u2193<\/p>\n

    Loading into lamellar granules<\/b><\/p>\n

    \u2193<\/p>\n

    Release of intercellular lipids in the stratum corneum<\/b><\/p>\n

    \u2193<\/p>\n

    Formation of a complete barrier-lipid structure<\/b><\/p>\n

    This supports the endogenous epidermal lipid-transport system rather than merely adding lipids from outside.<\/p>\n

    <\/p>\n

    Relative ABCA12 mRNA expression in a 3D epidermal model, *p<0.05 vs. control.<\/p>\n

    <\/p>\n

    ABCA12 immunofluorescence: stronger signal in the sodium trehalose sulfate group, 3D epidermal model.<\/p>\n

    Sources: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666; Sakai K, et al. Exp Dermatol.<\/i> 2007;16:920\u2013926.<\/p>\n

    CERAMIDE-RICH BARRIER<\/b><\/p>\n

    From ABCA12 to a Ceramide-Rich Barrier<\/h2>\n

    ABCA12 \u2191<\/b><\/p>\n

    \u2193<\/p>\n

    Lipid loading and transport \u2191<\/b><\/p>\n

    \u2193<\/p>\n

    Lamellar granules<\/b><\/p>\n

    \u2193<\/p>\n

    Intercellular lipids<\/b><\/p>\n

    \u2193<\/p>\n

    Ceramide-rich barrier<\/b><\/p>\n

    Immunofluorescence validation: stronger ceramide signal<\/b><\/p>\n

    <\/p>\n

    Control, left; sodium trehalose sulfate treatment, right<\/p>\n

    In a 3D epidermal model, the sodium trehalose sulfate group showed stronger ceramide immunofluorescence than the vehicle control, suggesting support for the organization of intercellular barrier lipids in the stratum corneum.<\/p>\n

    Why it matters:<\/b> Ceramides are core components of stratum-corneum intercellular lipids and determine barrier density. When ABCA12 function is impaired, lamellar-granule lipids decline and structural barrier defects emerge. Supporting ABCA12 supports the skin\u2019s own lipid supply chain.<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666, Figure 5C.<\/p>\n

    FILAGGRIN \u00b7 NMF PATHWAY<\/b><\/p>\n

    Activating the Skin\u2019s Natural Moisturizing Factor Pathway<\/h2>\n

    <\/p>\n

    Pathway by which FLG is degraded in the granular layer and stratum corneum to generate NMF, Maeda et al., 2024, Figure 1.<\/p>\n

    Profilaggrin in the granular layer<\/b><\/p>\n

    \u2193<\/p>\n

    Filaggrin (FLG)<\/b><\/p>\n

    \u2193<\/p>\n

    FLG processing and degradation: CASP14 \/ CAPN1 \/ BLMH<\/b><\/p>\n

    \u2193<\/p>\n

    Free amino acids<\/b><\/p>\n

    \u2193<\/p>\n

    Natural moisturizing factors (NMF)<\/b><\/p>\n

    \u2193<\/p>\n

    Stratum-corneum hydration<\/b><\/p>\n

    This is the skin\u2019s own moisturizing system, not water supplied from outside.<\/p>\n

    Sources: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666; Hoste E, et al. J Invest Dermatol.<\/i> 2011;131:2233\u20132241.<\/p>\n

    MULTI-GENE BARRIER RESPONSE<\/b><\/p>\n

    One Intervention Activates Seven Barrier-Related Pathways<\/h2>\n

    <\/p>\n

    3D epidermal-model qPCR: all seven mRNA markers were significantly upregulated by sodium trehalose sulfate, *p<0.05, **p<0.01 vs. control; n=3.<\/p>\n

    IVL Involucrin \u2191<\/b><\/p>\n

    TGM1 Transglutaminase 1 \u2191<\/b><\/p>\n

    ABCA12 Lipid transport \u2191<\/b><\/p>\n

    FLG Filaggrin \u2191<\/b><\/p>\n

    CASP14 \u2191<\/b><\/p>\n

    CAPN1 \u2191<\/b><\/p>\n

    BLMH \u2191<\/b><\/p>\n

    The response covers cornified-envelope formation, lipid transport and NMF production rather than a single target.<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666, Figure 4.<\/p>\n

    PROTEIN-LEVEL EVIDENCE<\/b><\/p>\n

    From Gene Expression to Barrier Structure<\/h2>\n

    TGM1<\/b><\/p>\n

    <\/p>\n

    Control, left; STS treatment, right<\/p>\n

    ABCA12<\/b><\/p>\n

    <\/p>\n

    Control, left; STS treatment, right<\/p>\n

    Ceramide<\/b><\/p>\n

    <\/p>\n

    Control, left; STS treatment, right<\/p>\n

    FLG<\/b><\/p>\n

    <\/p>\n

    Control, left; STS treatment, right<\/p>\n

    In 3D epidermal-model immunofluorescence, the sodium trehalose sulfate group showed greater fluorescence intensity and distribution area for TGM1, ABCA12, ceramide and FLG than the vehicle control. The evidence therefore extends beyond mRNA changes to proteins and barrier structure.<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666, Figure 5.<\/p>\n

    FREE AMINO ACIDS \u00b7 NMF SOURCE<\/b><\/p>\n

    Increasing the Source Materials for Natural Moisturizing Factors<\/h2>\n

    <\/p>\n

    Free amino acids \/ total amino acids, %, 3D epidermal model, n=4; *p<0.05, **p<0.01 vs. control.<\/p>\n

    Significant increases from 0.05% to 0.20%:<\/b> the 0.05%, 0.10% and 0.20% STS solution groups were all higher than control.<\/p>\n

    Free amino acids are core components of natural moisturizing factors and arise from filaggrin degradation. After sodium trehalose sulfate treatment, the free-amino-acid ratio in the 3D epidermal model was significantly higher than control.<\/p>\n

    It not only attracts water, but also supports the skin in producing its own natural moisturizing factors.<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666, Figure 6.<\/p>\n

    IMMEDIATE HYDRATION<\/b><\/p>\n

    Visible Improvement in Stratum-Corneum Water Content from 15 Minutes<\/h2>\n

    <\/p>\n

    Short-term human forearm test: change in stratum-corneum water content, \u0394\u03bcS, 15 \/ 30 min; n=5; *p<0.05, **p<0.01 vs. control.<\/p>\n

    15 min<\/b><\/p>\n

    An increase in water content was already observed.<\/p>\n

    30 min<\/b><\/p>\n

    The improvement persisted and remained significant.<\/p>\n

    After treatment with 0.05%, 0.1% and 0.2% sodium trehalose sulfate solutions, stratum-corneum water content was significantly higher than with the water control. The comparison 0.3% heparinoid emulsion was significant only at 15 minutes and no longer differed significantly from control at 30 minutes.<\/p>\n

    Immediate hydration and support for endogenous moisturization can be achieved together.<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666, Figure 7A.<\/p>\n

    TEWL \u00b7 BARRIER EFFICIENCY<\/b><\/p>\n

    Reducing Water Loss and Improving Barrier Efficiency<\/h2>\n

    <\/p>\n

    3D epidermal-model TEWL, g\/cm\u00b2\u00b7h, three days after treatment; n=3; *p<0.05 vs. control.<\/p>\n

    Transepidermal water loss is a core measure of skin-barrier integrity. Lower TEWL indicates a stronger ability to retain water. All three sodium trehalose sulfate concentration groups had significantly lower TEWL than control.<\/p>\n

    ABCA12 + ceramide + TGM1 \/ IVL<\/b><\/p>\n

    \u2193<\/p>\n

    Barrier integrity \u2191<\/b><\/p>\n

    \u2193<\/p>\n

    Water loss \u2193<\/b><\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666, Figure 7B.<\/p>\n

    HUMAN STUDY DESIGN<\/b><\/p>\n

    Four-Week Randomized Double-Blind Human Study<\/h2>\n

    Randomized<\/b><\/p>\n

    Random allocation<\/p>\n

    Double-blind<\/b><\/p>\n

    Double-blind design<\/p>\n

    Placebo-controlled<\/b><\/p>\n

    Placebo control<\/p>\n

    4 Weeks<\/b><\/p>\n

    Continuous facial use<\/p>\n\n\n\n\n\n\n\n\n
    Item<\/th>\nStudy information<\/th>\n<\/tr>\n
    Participants<\/td>\nIncluded in statistical analysis: active group n=13; placebo group n=11<\/td>\n<\/tr>\n
    Test formulations<\/td>\nActive group: toner and emulsion containing 0.05% sodium trehalose sulfate; placebo group: visually matched blank formulations<\/td>\n<\/tr>\n
    Use<\/td>\nTwice daily, morning and evening, for four weeks<\/td>\n<\/tr>\n
    Primary endpoints<\/td>\nTEWL and stratum-corneum water content<\/td>\n<\/tr>\n
    Ethics and enrollment<\/td>\nConducted according to the Declaration of Helsinki and approved by an ethics committee, protocol HENM21083001, 1 October 2021; 26 women aged 33\u201359 enrolled<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666.<\/p>\n

    4-WEEK CLINICAL RESULTS<\/b><\/p>\n

    Four Weeks of Use Improved Hydration and Barrier Function Together<\/h2>\n

    <\/p>\n

    TEWL, g\/m\u00b2\u00b7h: active-group mean W0\u2192W4, 17.3\u219216.1; between-group comparison of \u0394TEWL, p<0.01.<\/p>\n

    <\/p>\n

    Stratum-corneum water content, \u03bcS: active group 81.3\u2192105.5, p<0.01; between-group comparison of change, p<0.05.<\/p>\n

    Significant TEWL improvement<\/b><\/p>\n

    Active group \u0394 \u22121.2 vs placebo group \u0394 +3.2<\/p>\n

    Significant increase in stratum-corneum water content<\/b><\/p>\n

    Active group \u0394 +24.2 vs placebo group \u0394 +4.2<\/p>\n

    Significant between-group differences<\/b><\/p>\n

    Both core endpoints favored the active group<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666, Figures 8A and 8B; n=13 active \/ n=11 placebo.<\/p>\n

    HYDRATION + CLARITY<\/b><\/p>\n

    A Healthy Barrier Can Also Improve the Look of Skin<\/h2>\n

    <\/p>\n

    Blood oxygenation index: increased after four weeks in the active group; between-group comparison of change, p<0.05.<\/p>\n

    <\/p>\n

    Melanin index: decreased after four weeks in the active group; between-group comparison of change, p<0.05.<\/p>\n

    The paper also observed improvements in tone-related measures: blood oxygenation index \u2191 and melanin index \u2193.<\/p>\n

    These were accompanying observational endpoints in the four-week human study and do not support a strong whitening claim.<\/p>\n

    Suggested marketing language:<\/b> improves dry, dull appearance \u00b7 enhances a hydrated, translucent look \u00b7 supports a more even, healthy-looking skin tone \u00b7 provides barrier and hydration support for brightening products<\/p>\n

    Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666, Figures 8C and 8D.<\/p>\n

    DRY & SENSITIVE SKIN<\/b><\/p>\n

    Breaking the Barrier Damage\u2013Dryness\u2013Sensitivity Cycle<\/h2>\n

    Barrier disruption<\/b><\/p>\n

    \u2193<\/p>\n

    TEWL \u2191<\/b><\/p>\n

    \u2193<\/p>\n

    Dehydration<\/b><\/p>\n

    \u2193<\/p>\n

    Roughness and tightness<\/b><\/p>\n

    \u2193<\/p>\n

    Environmental sensitivity<\/b><\/p>\n

    \u2193<\/p>\n

    Further barrier disruption<\/b><\/p>\n

    Where sodium trehalose sulfate acts<\/b><\/p>\n

    Barrier:<\/b> supports the cornified envelope and barrier integrityLipids:<\/b> supports endogenous lipid transport and ceramide organizationNMF:<\/b> supports natural moisturizing factor productionHydration:<\/b> increases stratum-corneum water content and reduces TEWL<\/p>\n

    Suitable product concepts<\/b><\/p>\n

    Dry-skin care \u00b7 sensitive-skin barrier care \u00b7 seasonal-transition careMature dry skin \u00b7 companion care for high-activity products such as retinoids and acidsPost-cleansing tightness care<\/p>\n

    SCALP IS SKIN<\/b><\/p>\n

    The Scalp Also Needs an Intact Barrier<\/h2>\n

    <\/p>\n

    The scalp is an extension of the skin and similarly depends on:<\/p>\n

      \n
    • Stratum-corneum structure and the cornified envelope<\/li>\n
    • Intercellular lipids and ceramides<\/li>\n
    • Natural moisturizing factors and water balance<\/li>\n<\/ul>\n

      When the scalp barrier is impaired:<\/b> dryness \u00b7 tightness \u00b7 discomfort \u00b7 flaking \u00b7 reduced quality of hair appearance<\/p>\n

      PuriActives\u00ae Sodium Trehalose Sulfate can extend to:<\/b> scalp serum \u00b7 hair tonic \u00b7 shampoo \u00b7 conditioner \u00b7 scalp mask \u00b7 leave-on scalp essence<\/p>\n

      SULFATED SACCHARIDES PLATFORM<\/b><\/p>\n

      Sulfated Saccharides: an Emerging Scalp and Hair Research Platform<\/h2>\n

      This page concerns platform research on sulfated saccharides. It is not human hair-growth clinical evidence for sodium trehalose sulfate.<\/p>\n

      US 5,618,798: hair and scalp applications of sulfated saccharides<\/b><\/p>\n

      The patent covers topical use of sulfated monosaccharides, disaccharides and oligosaccharides in hair and scalp applications, including shampoo, hair tonic, hair conditioner, gel, emulsion and lotion formats.<\/p>\n

      Positioning of this page:<\/b> scalp moisture + barrier + hair environment. The focus is scalp moisturization and barrier care, not pharmaceutical hair-growth promotion.<\/p>\n

      Supporting studies on sulfated saccharides:<\/b><\/p>\n

        \n
      • US 4,912,093: synthetic sulfated saccharides and wound care<\/li>\n
      • WO 1989\/05646: sulfated saccharides and inflammatory skin care<\/li>\n
      • US 5,605,938: sulfated anionic polymers and cellular mechanisms<\/li>\n
      • FR 2877565: dextran sulfate and soothing applications<\/li>\n
      • Toyama S, et al. 2025: topical OJI-204 for skin dryness and dryness-induced itching, Biomedicines.<\/i> 2025;13:556<\/li>\n<\/ul>\n

        FORMULATION APPLICATIONS<\/b><\/p>\n

        Highly Flexible Applications from Serums to Scalp Care<\/h2>\n

        SKIN CARE<\/b><\/p>\n

        TonerEssence \/ serumAmpouleLotion \/ creamMaskEye careSensitive-skin care<\/p>\n

        HAIR & SCALP<\/b><\/p>\n

        ShampooConditionerScalp serumHair tonicScalp sprayHair mask<\/p>\n

        As a water-soluble, low-molecular-weight active, it is suitable for aqueous products, serums, emulsions, rinse-off scalp products and leave-on scalp products.<\/p>\n

        FORMULATION DESIGN<\/b><\/p>\n

        Building the Next Generation of Barrier-Moisturizing Systems<\/h2>\n

        STS + Hyaluronic Acid<\/b><\/p>\n

        Immediate water retention + support for the endogenous moisturizing system<\/p>\n

        STS + Ceramide<\/b><\/p>\n

        Endogenous lipid transport + exogenous lipid supplementation<\/p>\n

        STS + Panthenol<\/b><\/p>\n

        Barrier support + soothing care<\/p>\n

        STS + Ectoin<\/b><\/p>\n

        Environmental-stress care<\/p>\n

        STS + Niacinamide<\/b><\/p>\n

        Multidimensional barrier care<\/p>\n

        STS + Amino Acid \/ NMF Complex<\/b><\/p>\n

        Endogenous NMF generation + exogenous NMF supplementation<\/p>\n

        These formulation-design suggestions are based on complementary mechanisms. Actual performance of each combination requires validation in the specific formulation.<\/p>\n

        DOSE TRANSLATION<\/b><\/p>\n

        A 10% Active System Connected to the Published Human-Study Dose<\/h2>\n

        PuriActives\u00ae Sodium Trehalose Sulfate 10%: 10% active content in the ingredient<\/b><\/p>\n

        \u2193<\/p>\n

        Recommended finished-formula addition: 0.50%<\/b><\/p>\n

        \u2193<\/p>\n

        Actual sodium trehalose sulfate concentration in the formula: 0.05%<\/b><\/p>\n

        This directly corresponds to the 0.05% active concentration used in the human study by Maeda et al.<\/p>\n

        Studies at this concentration included a four-week randomized double-blind placebo-controlled human trial showing improvements in TEWL and stratum-corneum water content, a short-term human hydration test, and validation of genes, proteins and free amino acids in a 3D epidermal model.<\/p>\n

        Source: Maeda K, et al. Skin Res Technol.<\/i> 2024;30:e13666.<\/p>\n

        WHY PURIACTIVES\u00ae<\/b><\/p>\n

        PuriActives\u00ae Sodium Trehalose Sulfate 10%<\/h2>\n

        01 Barrier biology<\/b><\/p>\n

        ABCA12 \/ TGM1 \/ IVLSupports the cornified envelope and endogenous lipid transport<\/p>\n

        02 Endogenous moisturization<\/b><\/p>\n

        FLG \/ NMF \/ free amino acidsSupports the skin in producing its own moisturizing factors<\/p>\n

        03 Human validation<\/b><\/p>\n

        Four-week randomized double-blind studyTEWL \u2193 \u00b7 stratum-corneum water content \u2191<\/p>\n

        04 Dual-scenario application<\/b><\/p>\n

        Skin + scalpOne platform for skin and scalp care<\/p>\n

        Lasting moisturization means more than bringing water into the skin. It also means helping the skin manage its own water.<\/b><\/p>\n

        REFERENCES<\/b>Maeda K, Zhou Z, Guo M, Zhang J, Chen L, Yang F. Functional properties and skin care effects of sodium trehalose sulfate. Skin Res Technol.<\/i> 2024;30:e13666. doi:10.1111\/srt.13666Hoste E, et al. J Invest Dermatol.<\/i> 2011;131:2233\u20132241. \u00b7 Denecker G, et al. Nat Cell Biol.<\/i> 2007;9:666\u2013674. \u00b7 Sakai K, et al. Exp Dermatol.<\/i> 2007;16:920\u2013926.Supporting platform research on sulfated saccharides: US 4,912,093 \u00b7 US 5,618,798 \u00b7 WO 1989\/05646 \u00b7 US 5,605,938 \u00b7 FR 2877565 \u00b7 Toyama S, et al. Biomedicines.<\/i> 2025;13:556.<\/p>\n

        PuriPharm Co. Ltd.<\/b>www.puriactives.com \u00b7 service@puripharm.com+86-572-2745768 \u00b7 Building 6, No. 1366 Hongfeng Road, Huzhou, Zhejiang, ChinaPuriActives\u00ae is a registered trademark of PuriPharm Co., Ltd. This material introduces a cosmetic ingredient.<\/p>\n","protected":false},"excerpt":{"rendered":"

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