The limitation of native chitosan<\/h3>\n\n- Its amino-group charge exists only below pKa \u2248 6.3\u20136.5; above that range, both charge and solubility collapse.<\/li>\n
- It requires acidic systems, limiting dosage-form choices and active-ingredient combinations.<\/li>\n
- Its performance is weakest across the true pH range of skin and hair products (4.5\u20137).<\/li>\n<\/ul>\n
New market requirements<\/h3>\n\n- Bio-based, biodegradable conditioning polymers.<\/li>\n
- Multifunctionality in one ingredient: conditioning + moisturization + microbial support.<\/li>\n
- Rinse-resistant deposition without build-up or tackiness.<\/li>\n<\/ul>\n
![](\"https:\/\/pic-out.zhimg.com\/v2-40d103f2a9965be9956873f90ac9acbc~resize:1440:q75.jpg?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-3f58da0ffb3f32f57009dc93209afae8&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
![](\"https:\/\/pic-out.zhimg.com\/v2-911328f1e73e6dd3b8c5833e05626f30~resize:1440:q75.png?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-f868cdfdcd5af1b57bcbc8470676ed71&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
Sources: chitosan pKa and pH-dependent charge\u2014J. Mater. Chem. B 2023; ACS Appl. Mater. Interfaces 2023.<\/p>\n
02 \u00b7 PRODUCT OVERVIEW<\/p>\n
One molecule, two care categories.<\/h2>\n
PuriActives\u00ae ChitoQ is a quaternized chitosan: a marine-derived polysaccharide carrying permanent quaternary ammonium groups. It is water-compatible, permanently cationic, and multifunctional for both leave-on and rinse-off systems.<\/p>\n
\n- Cationic affinity deposition on hair keratin and skin surfaces.<\/li>\n
- Conditioning, cuticle smoothing, and anti-static performance.<\/li>\n
- Moisturization benchmarked against hyaluronic acid.<\/li>\n
- Broad-spectrum antimicrobial and anti-biofilm support.<\/li>\n
- A bio-based, biodegradable alternative to synthetic polyquaterniums.<\/li>\n<\/ul>\n
![](\"https:\/\/pic-out.zhimg.com\/v2-b0b82f2d9426f4dd4e590f6efd25e4e6~resize:1440:q75.jpg?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-8d7bbfdeab7996a78c80b6fc3ba9b527&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
\n\n\npH 3\u201310Maintains permanent cationic character across the formulation pH window<\/td>\n 0.625 mg\/mLMIC against Streptococcus mutans\u201490% growth inhibition in vitro<\/td>\n<\/tr>\n \n98.5%Degree of substitution in the current batch (specification \u2265 80%)<\/td>\n CosIngEU-listed INCI\u2014functions: hair conditioning and humectant<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nSources: Gao et al., Molecules 2024 (S. mutans, in vitro); EU CosIng database; Puripharm batch COA (May 2026).<\/p>\n
03 \u00b7 MOLECULAR DESIGN<\/p>\n
From chitosan to ChitoQ: functional quaternization<\/h2>\n
![](\"https:\/\/pic-out.zhimg.com\/v2-c7db362bc053c04b43630f8bbd6d55d9~resize:1440:q75.png?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-5509fff14a96d8cae1ccb5282fa64434&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
Permanent cationic charge<\/h3>\n
Quaternary ammonium groups never deprotonate, preserving charge across the full cosmetic pH range.<\/p>\n
True water compatibility<\/h3>\n
It dissolves directly in water without acidification\u2014add it to the water phase and formulate freely.<\/p>\n
Stronger surface affinity<\/h3>\n
Electrostatic binding to anionic keratin and skin surfaces drives affinity deposition and film formation.<\/p>\n
The quaternization route follows the published synthesis of N-2-hydroxypropyltrimethylammonium chloride chitosan (Gao et al., Molecules 2024).<\/p>\n
04 \u00b7 PHYSICOCHEMICAL PROPERTIES<\/p>\n
Positive charge at any formulation pH<\/h2>\n
![](\"https:\/\/pic-out.zhimg.com\/v2-0a737c78e1fbf54df8f03874bbec68b6~resize:1440:q75.png?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-4365e839b94112404821f5e3db822f69&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
Unconditional charge<\/h3>\n
Quaternary ammonium groups remain protonated from acidic to weakly alkaline media\u2014affinity deposition no longer depends on pH.<\/p>\n
Soluble where chitosan is not<\/h3>\n
High-substitution HACC forms clear aqueous solutions (transmittance >80% at 80% substitution)\u2014no acidification or pre-dissolution required.<\/p>\n
Built for deposition<\/h3>\n
High permanent charge density maximizes electrostatic interaction with anionic keratin and skin\u2014the physical basis for conditioning and film formation.<\/p>\n
Sources: ACS Appl. Mater. Interfaces 2023 (zeta potential of quaternized chitosan, pH 3\u201310); ACS Omega 2021 (QCS charge retention); Gao et al., Molecules 2024 (solubility).<\/p>\n
05 \u00b7 MECHANISM OF ACTION<\/p>\n
Designed to bind precisely where damage occurs<\/h2>\n
![](\"https:\/\/pic-out.zhimg.com\/v2-a4c8f823cd5973d9e090f2b76dfb07d8~resize:1440:q75.png?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-65da7ea507bc66c2d87cf78c760aa3c6&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
\n- Selective attraction:<\/b> the isoelectric point of hair keratin is approximately 3.67. At cosmetic pH, hair carries a net negative charge, and damaged fibres are even more negatively charged.<\/li>\n
- Cationic deposition:<\/b> ChitoQ adsorbs to anionic sites through electrostatic interaction, concentrating deposition where the fibre needs it most and resisting rinse-off.<\/li>\n
- Conditioning film:<\/b> the bound polymer forms a smooth, hydrophilic film that lays cuticles flat, reduces friction and static, and helps retain surface moisture.<\/li>\n<\/ol>\n
The same physical mechanism works on skin: an affinity, breathable cationic film binds water and supports the surface barrier\u2014one mechanism, two categories.<\/p>\n
Source: hair isoelectric point and cationic deposition mechanism\u2014Gavazzoni Dias et al., On Hair Care Physicochemistry, Int. J. Trichology \/ PMC9921463.<\/p>\n
![](\"https:\/\/pic-out.zhimg.com\/v2-927b4f7506581d4290f3d1b429702f52~resize:1440:q75.jpg?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-17fd43697c385f61fe4179c59977ffae&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
EVIDENCE SECTION<\/p>\n
Performance evidence<\/h2>\n
Quantified results from peer-reviewed research on ChitoQ chemistry, presented with transparent evidence grading.<\/p>\n
A<\/b> | Studies on ChitoQ chemistry itself (Chitosan Hydroxypropyltrimonium Chloride)<\/p>\n
B<\/b> | Structurally similar quaternized chitosan\u2014mechanistic support<\/p>\n
C<\/b> | General chitosan literature\u2014physicochemical background<\/p>\n
06 \u00b7 HAIR-CARE PERFORMANCE<\/p>\n
Affinity conditioning beyond rinse-off<\/h2>\n
A cationic film restores surface smoothness and shine.<\/p>\n
Targeted deposition on damaged keratin [B]<\/h3>\n
The affinity of quaternized chitosan for hair keratin has been demonstrated, and its strengthening and conditioning effects have been documented since the earliest quaternized-chitosan patents.<\/p>\n
Easier wet and dry combing [C]<\/h3>\n
The adsorbed film reduces inter-fibre friction, helps detangling, and reduces mechanical breakage during combing.<\/p>\n
Anti-static and frizz control [C]<\/h3>\n
Charge neutralization plus a smoothing film minimizes static and seals cuticles against humidity-induced frizz.<\/p>\n
Shine, softness, and color protection [C]<\/h3>\n
Flat cuticles reflect light evenly, while the protective film helps color resist washing and UV exposure.<\/p>\n
Added scalp-care benefit [A]<\/h3>\n
Demonstrated antimicrobial activity extends the benefit from the hair fibre to the scalp environment.<\/p>\n
Damaged hair has a lower isoelectric point and a denser negative surface charge, so cationic polymers deposit preferentially where repair is most needed.<\/p>\n
Sources: US 4,772,689 (Lang et al., quaternized-chitosan affinity); PCACD 2024 review (chitosan hair care); Gao et al., Molecules 2024. See the evidence section for [A]\/[B]\/[C] grading.<\/p>\n
07 \u00b7 SKIN-CARE PERFORMANCE<\/p>\n
Hyaluronic-acid-level moisturization<\/h2>\n
![](\"https:\/\/pic-out.zhimg.com\/v2-1b02de411b9fc463d7a1a5900c20c8c5~resize:1440:q75.png?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-6eef11e56042eb1eb3f493510e33639b&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
[A] HACC performs within the hyaluronic-acid range, and its ion-exchange derivative can reach 2.2\u00d7 HA. At 43% RH, the HACC derivative also absorbed more moisture than HA (74\u201394% vs 32.4%, 48 h).<\/p>\n
Dual water management<\/h3>\n
A surface rich in hydroxyl and quaternary ammonium groups binds water through hydrogen bonding, while the affinity film helps slow transepidermal water loss. [A\/C]<\/p>\n
Breathable barrier support<\/h3>\n
Chitosan films are non-occlusive: they buffer the stratum corneum against environmental stress while allowing skin to function normally. [C]<\/p>\n
Sensory differentiation<\/h3>\n
The cationic film provides a distinctive smooth, cushioned after-feel\u2014a humectant consumers can actually perceive. [C]<\/p>\n
Sources: Mi et al., Polymers 2021 (PMC8307204)\u2014in vitro comparison of moisture absorption\/retention by HACC, its derivatives, and sodium hyaluronate; chitosan film\/TEWL literature (PCACD 2024).<\/p>\n
08 \u00b7 ANTIMICROBIAL SUPPORT<\/p>\n
A cationic mechanism acting on microbial surfaces<\/h2>\n
\n\n\n0.625 mg\/mLMIC of N-2-HACC against S. mutans; 90.0% growth inhibition at the MIC [A]<\/td>\n > 90%Inhibition of E. coli and S. aureus by quaternized chitosan salts at 0.5 mg\/mL [B]<\/td>\n BiofilmFormation is significantly inhibited, with activity increasing as substitution degree rises [A\/B]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n![](\"https:\/\/pic-out.zhimg.com\/v2-f05e2a9911bba0bf9b3c95ea68479056~resize:1440:q75.jpg?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-59f8df863f92763184e891f1b65d276b&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
How the permanent charge works [A]<\/h3>\n\n- Electrostatic binding to negatively charged cell envelopes.<\/li>\n
- Increased cell-wall permeability (alkaline phosphatase leakage).<\/li>\n
- Disrupted membrane integrity\u2014visible pitting under SEM.<\/li>\n
- Inhibited respiratory metabolism and protein\/DNA synthesis.<\/li>\n<\/ul>\n
Gentle, film-forming antimicrobial support for leave-on systems. Position it as preservative-boosting support; actual in-formula performance must be confirmed by preservative challenge testing.<\/p>\n
Sources: [A] Gao et al., Molecules 2024 (N-2-HACC against S. mutans; MIC\/SEM\/biofilm); [B] Wang et al., Int. J. Biol. Macromol. 2024 (chitosan quaternary ammonium salts; E. coli\/S. aureus).<\/p>\n
09 \u00b7 SAFETY AND MILDNESS<\/p>\n
Cationic performance without the baggage<\/h2>\n
ChitoQ carries its charge on a high-molecular-weight polysaccharide backbone\u2014it stays on the surface where it works, rather than penetrating like a small-molecule quaternary ammonium salt.<\/p>\n
No cytotoxicity in cell testing [A]<\/h3>\n
HACC-based derivatives showed no significant toxicity toward L929 fibroblasts; independent literature describes N-2-HACC as having very low toxicity and high safety.<\/p>\n
Bio-based and biodegradable [A\/C]<\/h3>\n
The marine-derived polysaccharide backbone addresses sustainability and environmental-persistence concerns associated with traditional synthetic cationic polymers.<\/p>\n
Built-in antioxidant benefit [A]<\/h3>\n
Beyond conditioning, HACC derivatives show free-radical scavenging activity (DPPH and superoxide anion).<\/p>\n
A high-molecular-weight cationic biopolymer designed for surface action. Finished-formula suitability and regulatory compliance remain the responsibility of the product developer; a complete toxicology dossier is available upon request.<\/p>\n
Sources: Han et al., Int. J. Biol. Macromol. 2024 (L929 cytotoxicity and antioxidant assays); Gao et al., Molecules 2024; Processes 2026 review (limitations of cationic systems).<\/p>\n
10 \u00b7 HAIR + SCALP SYNERGY<\/p>\n
One functional biopolymer\u2014two cosmetic interfaces<\/h2>\n
![](\"https:\/\/pic-out.zhimg.com\/v2-39e0b65d19378b5a9a922f872a8e2ca3~resize:1440:q75.png?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-dff5812a2346880565ccb79397dda1da&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
Hair fibre<\/h3>\n\n- Targeted deposition [B]:<\/b> cationic chains anchor to negatively charged damaged keratin sites.<\/li>\n
- Cuticle smoothing [C]:<\/b> the adsorbed film lays raised cuticles flat and reduces inter-fibre friction.<\/li>\n
- Anti-static control [C]:<\/b> charge neutralization tames static and humidity-induced frizz.<\/li>\n
- Protective conditioning layer [B]:<\/b> the affinity polymer film helps protect hair from daily mechanical damage.<\/li>\n<\/ul>\n
Scalp<\/h3>\n\n- Moisture management [B]:<\/b> the humectant polysaccharide film helps retain water at the scalp surface.<\/li>\n
- Surface comfort film [C]:<\/b> an ultra-thin polymer layer provides a smooth, protected skin feel.<\/li>\n
- Microenvironment support [A]:<\/b> demonstrated antimicrobial activity supports scalp-care concepts.<\/li>\n
- Formulation support [A]:<\/b> water-phase compatibility simplifies scalp lotions, essences, and cleansing formulas.<\/li>\n<\/ul>\n
The charge-affinity mechanism that conditions hair also serves the skin where hair grows.<\/p>\n
See the evidence section for grading. Sources: Gao et al., Molecules 2024 [A]; Mi et al., Polymers 2021 [B]; US 4,772,689 [B].<\/p>\n
11 \u00b7 PERFORMANCE ARCHITECTURE<\/p>\n
One polymer, six cosmetic functions.<\/h2>\n01 CONDITION | Affinity cationic deposition<\/h3>\n
Permanent charge anchors the polymer to hair keratin and skin surfaces for rinse-resistant conditioning. [B]<\/p>\n
02 SMOOTH | Film-forming surface refinement<\/h3>\n
An ultra-thin adsorbed film smooths cuticles and skin microrelief, reducing friction and roughness. [C]<\/p>\n
03 HYDRATE | Water retention and binding<\/h3>\n
The hydrophilic polysaccharide structure binds water, with moisturization benchmarked against hyaluronic acid. [B]<\/p>\n
04 PROTECT | Polymer protective interface<\/h3>\n
The deposited layer buffers hair fibres and skin surfaces against mechanical and environmental stress. [C]<\/p>\n
05 CONTROL | Anti-static and manageability<\/h3>\n
Charge neutralization reduces static and makes wet and dry combing easier. [C]<\/p>\n
06 SUPPORT | Skin and scalp-care functions<\/h3>\n
Demonstrated antimicrobial and moisturizing activity extends care from hair fibres to scalp and skin. [A]<\/p>\n
Molecule \u2192 mechanism \u2192 performance \u2192 formulation \u2192 consumer benefit<\/p>\n
The functional portfolio is limited to scientifically supported roles; see the evidence section for grading.<\/p>\n
12 \u00b7 APPLICATION OPPORTUNITIES<\/p>\n
One ingredient, two care categories<\/h2>\nHair and scalp<\/h3>\n\n- Conditioning shampoos\u2014deposition without build-up; compatible with amphoteric surfactant systems.<\/li>\n
- Rinse-off conditioners and masks\u2014wet-combing slip, cuticle sealing, and shine.<\/li>\n
- Leave-on anti-frizz serums\/sprays\u2014an anti-static film with humidity resistance.<\/li>\n
- Scalp lotions\u2014moisturization plus microbial-balance support.<\/li>\n
- Color-care systems\u2014film protection against wash-out and UV fading.<\/li>\n<\/ul>\n
Face and body<\/h3>\n\n- Moisturizing serums\/essences\u2014hyaluronic-acid-level hydration with a perceptibly cushioned skin feel.<\/li>\n
- Moisturizers and barrier creams\u2014a breathable film that slows water loss.<\/li>\n
- Sheet-mask essences\u2014affinity hydration that lasts after mask removal.<\/li>\n
- Facial mists\/toners\u2014water-clear and non-tacky.<\/li>\n
- Gentle cleansers\u2014a conditioned after-feel with a microbial-support story.<\/li>\n<\/ul>\n
Every concept inherits the same trio: affinity deposition \u00b7 moisturization \u00b7 microbial support<\/p>\n
Concept directions are provided for development reference only; prototype formulas are available from the Puripharm application laboratory.<\/p>\n
13 \u00b7 FORMULATION GUIDE<\/p>\n
Born for the water phase<\/h2>\n
\n\n\nParameter<\/th>\n Guidance<\/th>\n<\/tr>\n \nINCI \/ form<\/td>\n Chitosan Hydroxypropyltrimonium Chloride\u2014off-white powder<\/td>\n<\/tr>\n \nUse level<\/td>\n Varies by dosage form\u2014the Puripharm application laboratory provides system-specific starting recommendations<\/td>\n<\/tr>\n \nSolubility<\/td>\n Readily soluble in water across a broad pH window\u2014no acidification required<\/td>\n<\/tr>\n \nWorking pH<\/td>\n Functional pH 3\u201310; comfortable formulation range pH 4\u20138<\/td>\n<\/tr>\n \nAddition<\/td>\n Disperse in the water phase under moderate stirring until clear<\/td>\n<\/tr>\n \nCompatibility<\/td>\n Cationic\u2014avoid strongly anionic surfactants\/polymers; best paired with nonionic and amphoteric systems<\/td>\n<\/tr>\n \nProcess tolerance<\/td>\n The polysaccharide backbone is stable; add below 80 \u00b0C to protect color and viscosity<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nFormulator notes<\/h3>\n\n- Rinse-off products: deposit first, rinse second\u2014affinity withstands dilution.<\/li>\n
- Screen salts\u2014high ionic strength compresses charge interactions.<\/li>\n
- Brings light, elegant viscosity to aqueous systems.<\/li>\n
- Pair with humectants (glycerin, betaine, PCA) to strengthen the hydration story.<\/li>\n
- Confirm preservative synergy in the final base through challenge testing.<\/li>\n<\/ul>\n
Prototype formulas (conditioning shampoo, moisturizing serum, and scalp lotion) are available from the Puripharm application laboratory.<\/p>\n
Guidance is based on published physicochemical behavior of quaternized chitosan and Puripharm application experience; validate in the final formula.<\/p>\n
14 \u00b7 DIFFERENTIATION<\/p>\n
A bio-based answer to synthetic cationic polymers<\/h2>\n
\n\n\nDimension<\/th>\n PURIACTIVES\u00ae CHITOQ<\/th>\n Native chitosan<\/th>\n Synthetic polyquaterniums<\/th>\n<\/tr>\n \nSource<\/td>\n Marine-derived, bio-based<\/td>\n Marine-derived, bio-based<\/td>\n Petrochemical<\/td>\n<\/tr>\n \nCharge vs pH<\/td>\n Permanently cationic, pH 3\u201310<\/td>\n Only below pKa \u2248 6.5<\/td>\n Permanently cationic<\/td>\n<\/tr>\n \nWater compatibility<\/td>\n Direct dissolution, no acidification<\/td>\n Acidic media only<\/td>\n Good<\/td>\n<\/tr>\n \nAffinity<\/td>\n High\u2014keratin and skin<\/td>\n Moderate, pH-limited<\/td>\n High<\/td>\n<\/tr>\n \nMultifunctionality<\/td>\n Conditioning + moisturization + antimicrobial support<\/td>\n Film-forming and moisturizing<\/td>\n Conditioning only<\/td>\n<\/tr>\n \nEnd of life<\/td>\n Biodegradable polysaccharide<\/td>\n Biodegradable<\/td>\n Persistence concern<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nSynthetic-grade performance with a biopolymer story\u2014without naming any commercial competitor.<\/p>\n
15 \u00b7 QUALITY AND REGULATORY<\/p>\n
Batch traceability\u2014all 11 tests passed<\/h2>\nSpecification vs representative production batch<\/h3>\n
\n\n\nTest item<\/th>\n Specification<\/th>\n Batch result<\/th>\n<\/tr>\n \nAppearance<\/td>\n Off-white powder<\/td>\n Complies<\/td>\n<\/tr>\n \nSolubility<\/td>\n Soluble in deionized water<\/td>\n Complies<\/td>\n<\/tr>\n \nMoisture<\/td>\n \u2264 10.0%<\/td>\n 8.7%<\/td>\n<\/tr>\n \nAsh<\/td>\n \u2264 1.0%<\/td>\n 0.45%<\/td>\n<\/tr>\n \npH (1% solution)<\/td>\n 5.5\u20137.5<\/td>\n 6.41<\/td>\n<\/tr>\n \nViscosity (1% aqueous solution, 20 \u00b0C)<\/td>\n Meets product claim<\/td>\n 18 mPa\u00b7s<\/td>\n<\/tr>\n \nDegree of deacetylation<\/td>\n \u2265 85.0%<\/td>\n 89.2%<\/td>\n<\/tr>\n \nDegree of substitution<\/td>\n \u2265 80.0%<\/td>\n 98.5%<\/td>\n<\/tr>\n \nArsenic (As)<\/td>\n \u2264 4.0 mg\/kg<\/td>\n Not detected (< 0.01)<\/td>\n<\/tr>\n \nLead (Pb)<\/td>\n \u2264 2.0 mg\/kg<\/td>\n Not detected (< 0.02)<\/td>\n<\/tr>\n \nWater-insoluble matter<\/td>\n \u2264 0.5%<\/td>\n 0.03%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n11 \/ 11All quality tests passed for the current production batch<\/td>\n 98.5%Degree of substitution; specification \u2265 80%<\/td>\n NDArsenic and lead below detection limits (< 0.01 \/ < 0.02 mg\/kg)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nRegulatory identity<\/h3>\n
The INCI name Chitosan Hydroxypropyltrimonium Chloride is listed in the EU CosIng database with hair-conditioning and humectant functions. Each batch is supplied with COA, TDS, and SDS.<\/p>\n
Puripharm Co., Ltd. batch inspection report (May 2026); complete COA, TDS, and SDS are available upon request. EU CosIng listed functions: hair conditioning and humectant.<\/p>\n
16 \u00b7 SUMMARY<\/p>\n
ChitoQ earns a place in your formula<\/h2>\n
Marine chitosan backbone \u2192 functional quaternization \u2192 water compatibility + permanent charge \u2192 biological surface binding \u2192 multifunctional performance<\/p>\n
No more formulation compromise<\/h3>\n
Water compatibility across pH 3\u201310 ends the acidic-system constraint of native chitosan.<\/p>\n
Performance that stays<\/h3>\n
Permanent cationic affinity delivers rinse-resistant conditioning and moisturization.<\/p>\n
A cleaner label story<\/h3>\n
Bio-based, biodegradable, and clean in cell testing\u2014a credible successor to synthetic polyquaterniums.<\/p>\n
Honestly graded evidence<\/h3>\n
ChitoQ-specific data lead the story; related quaternized-chitosan and chitosan literature is clearly labeled.<\/p>\n
One SKU, three functions<\/h3>\n
Conditioning, moisturization, and antimicrobial support simplify formulas and strengthen claims.<\/p>\n
End-to-end support<\/h3>\n
Specifications, dossiers, and prototype formulas travel with the ingredient\u2014not as an afterthought.<\/p>\n
ChitoQ turns an exceptional biopolymer into a reliable formulation tool.<\/p>\n
![](\"https:\/\/pic-out.zhimg.com\/v2-7f7eb6e6d8422d296612a3ce2c350304~resize:1440:q75.jpg?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790167889-0-0-80d35e6035cde5a24248590ab98b9fa4&bizSceneCode=article_draft&expiration=1790167889&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
<\/p>\n
PURIPHARM CO., LTD.<\/p>\n
Let\u2019s build the next generation of care products together.<\/h2>\n
Request PuriActives\u00ae ChitoQ samples, specifications, safety dossiers, and prototype formulas.<\/p>\n
\n\n\nWebsite<\/td>\n www.puriactives.com<\/td>\n<\/tr>\n \nEmail<\/td>\n service@puripharm.com<\/td>\n<\/tr>\n \nPhone<\/td>\n +86-572-2745768<\/td>\n<\/tr>\n \nAddress<\/td>\n Building 6, No. 1366 Hongfeng Road, Huzhou, Zhejiang, China<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nPuriActives\u00ae and ChitoQ\u00ae are registered trademarks of Puripharm Co., Ltd. This presentation introduces a cosmetic ingredient only and contains no drug claims. In vitro and third-party literature data are identified and do not represent clinical performance of finished products.<\/p>\n","protected":false},"excerpt":{"rendered":"
PuriActives\u00ae ChitoQ INCI: Chitosan Hydroxypropyltrimoni […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[35,27],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1404"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1404"}],"version-history":[{"count":1,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1404\/revisions"}],"predecessor-version":[{"id":1405,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1404\/revisions\/1405"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1404"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
New market requirements<\/h3>\n\n- Bio-based, biodegradable conditioning polymers.<\/li>\n
- Multifunctionality in one ingredient: conditioning + moisturization + microbial support.<\/li>\n
- Rinse-resistant deposition without build-up or tackiness.<\/li>\n<\/ul>\n
<\/p>\n
Sources: chitosan pKa and pH-dependent charge\u2014J. Mater. Chem. B 2023; ACS Appl. Mater. Interfaces 2023.<\/p>\n
02 \u00b7 PRODUCT OVERVIEW<\/p>\n
One molecule, two care categories.<\/h2>\n
PuriActives\u00ae ChitoQ is a quaternized chitosan: a marine-derived polysaccharide carrying permanent quaternary ammonium groups. It is water-compatible, permanently cationic, and multifunctional for both leave-on and rinse-off systems.<\/p>\n
\n- Cationic affinity deposition on hair keratin and skin surfaces.<\/li>\n
- Conditioning, cuticle smoothing, and anti-static performance.<\/li>\n
- Moisturization benchmarked against hyaluronic acid.<\/li>\n
- Broad-spectrum antimicrobial and anti-biofilm support.<\/li>\n
- A bio-based, biodegradable alternative to synthetic polyquaterniums.<\/li>\n<\/ul>\n
<\/p>\n
\n\n\npH 3\u201310Maintains permanent cationic character across the formulation pH window<\/td>\n 0.625 mg\/mLMIC against Streptococcus mutans\u201490% growth inhibition in vitro<\/td>\n<\/tr>\n \n98.5%Degree of substitution in the current batch (specification \u2265 80%)<\/td>\n CosIngEU-listed INCI\u2014functions: hair conditioning and humectant<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nSources: Gao et al., Molecules 2024 (S. mutans, in vitro); EU CosIng database; Puripharm batch COA (May 2026).<\/p>\n
03 \u00b7 MOLECULAR DESIGN<\/p>\n
From chitosan to ChitoQ: functional quaternization<\/h2>\n
<\/p>\n
Permanent cationic charge<\/h3>\n
Quaternary ammonium groups never deprotonate, preserving charge across the full cosmetic pH range.<\/p>\n
True water compatibility<\/h3>\n
It dissolves directly in water without acidification\u2014add it to the water phase and formulate freely.<\/p>\n
Stronger surface affinity<\/h3>\n
Electrostatic binding to anionic keratin and skin surfaces drives affinity deposition and film formation.<\/p>\n
The quaternization route follows the published synthesis of N-2-hydroxypropyltrimethylammonium chloride chitosan (Gao et al., Molecules 2024).<\/p>\n
04 \u00b7 PHYSICOCHEMICAL PROPERTIES<\/p>\n
Positive charge at any formulation pH<\/h2>\n
<\/p>\n
Unconditional charge<\/h3>\n
Quaternary ammonium groups remain protonated from acidic to weakly alkaline media\u2014affinity deposition no longer depends on pH.<\/p>\n
Soluble where chitosan is not<\/h3>\n
High-substitution HACC forms clear aqueous solutions (transmittance >80% at 80% substitution)\u2014no acidification or pre-dissolution required.<\/p>\n
Built for deposition<\/h3>\n
High permanent charge density maximizes electrostatic interaction with anionic keratin and skin\u2014the physical basis for conditioning and film formation.<\/p>\n
Sources: ACS Appl. Mater. Interfaces 2023 (zeta potential of quaternized chitosan, pH 3\u201310); ACS Omega 2021 (QCS charge retention); Gao et al., Molecules 2024 (solubility).<\/p>\n
05 \u00b7 MECHANISM OF ACTION<\/p>\n
Designed to bind precisely where damage occurs<\/h2>\n
<\/p>\n
\n- Selective attraction:<\/b> the isoelectric point of hair keratin is approximately 3.67. At cosmetic pH, hair carries a net negative charge, and damaged fibres are even more negatively charged.<\/li>\n
- Cationic deposition:<\/b> ChitoQ adsorbs to anionic sites through electrostatic interaction, concentrating deposition where the fibre needs it most and resisting rinse-off.<\/li>\n
- Conditioning film:<\/b> the bound polymer forms a smooth, hydrophilic film that lays cuticles flat, reduces friction and static, and helps retain surface moisture.<\/li>\n<\/ol>\n
The same physical mechanism works on skin: an affinity, breathable cationic film binds water and supports the surface barrier\u2014one mechanism, two categories.<\/p>\n
Source: hair isoelectric point and cationic deposition mechanism\u2014Gavazzoni Dias et al., On Hair Care Physicochemistry, Int. J. Trichology \/ PMC9921463.<\/p>\n
<\/p>\n
EVIDENCE SECTION<\/p>\n
Performance evidence<\/h2>\n
Quantified results from peer-reviewed research on ChitoQ chemistry, presented with transparent evidence grading.<\/p>\n
A<\/b> | Studies on ChitoQ chemistry itself (Chitosan Hydroxypropyltrimonium Chloride)<\/p>\n
B<\/b> | Structurally similar quaternized chitosan\u2014mechanistic support<\/p>\n
C<\/b> | General chitosan literature\u2014physicochemical background<\/p>\n
06 \u00b7 HAIR-CARE PERFORMANCE<\/p>\n
Affinity conditioning beyond rinse-off<\/h2>\n
A cationic film restores surface smoothness and shine.<\/p>\n
Targeted deposition on damaged keratin [B]<\/h3>\n
The affinity of quaternized chitosan for hair keratin has been demonstrated, and its strengthening and conditioning effects have been documented since the earliest quaternized-chitosan patents.<\/p>\n
Easier wet and dry combing [C]<\/h3>\n
The adsorbed film reduces inter-fibre friction, helps detangling, and reduces mechanical breakage during combing.<\/p>\n
Anti-static and frizz control [C]<\/h3>\n
Charge neutralization plus a smoothing film minimizes static and seals cuticles against humidity-induced frizz.<\/p>\n
Shine, softness, and color protection [C]<\/h3>\n
Flat cuticles reflect light evenly, while the protective film helps color resist washing and UV exposure.<\/p>\n
Added scalp-care benefit [A]<\/h3>\n
Demonstrated antimicrobial activity extends the benefit from the hair fibre to the scalp environment.<\/p>\n
Damaged hair has a lower isoelectric point and a denser negative surface charge, so cationic polymers deposit preferentially where repair is most needed.<\/p>\n
Sources: US 4,772,689 (Lang et al., quaternized-chitosan affinity); PCACD 2024 review (chitosan hair care); Gao et al., Molecules 2024. See the evidence section for [A]\/[B]\/[C] grading.<\/p>\n
07 \u00b7 SKIN-CARE PERFORMANCE<\/p>\n
Hyaluronic-acid-level moisturization<\/h2>\n
<\/p>\n
[A] HACC performs within the hyaluronic-acid range, and its ion-exchange derivative can reach 2.2\u00d7 HA. At 43% RH, the HACC derivative also absorbed more moisture than HA (74\u201394% vs 32.4%, 48 h).<\/p>\n
Dual water management<\/h3>\n
A surface rich in hydroxyl and quaternary ammonium groups binds water through hydrogen bonding, while the affinity film helps slow transepidermal water loss. [A\/C]<\/p>\n
Breathable barrier support<\/h3>\n
Chitosan films are non-occlusive: they buffer the stratum corneum against environmental stress while allowing skin to function normally. [C]<\/p>\n
Sensory differentiation<\/h3>\n
The cationic film provides a distinctive smooth, cushioned after-feel\u2014a humectant consumers can actually perceive. [C]<\/p>\n
Sources: Mi et al., Polymers 2021 (PMC8307204)\u2014in vitro comparison of moisture absorption\/retention by HACC, its derivatives, and sodium hyaluronate; chitosan film\/TEWL literature (PCACD 2024).<\/p>\n
08 \u00b7 ANTIMICROBIAL SUPPORT<\/p>\n
A cationic mechanism acting on microbial surfaces<\/h2>\n
\n\n\n0.625 mg\/mLMIC of N-2-HACC against S. mutans; 90.0% growth inhibition at the MIC [A]<\/td>\n > 90%Inhibition of E. coli and S. aureus by quaternized chitosan salts at 0.5 mg\/mL [B]<\/td>\n BiofilmFormation is significantly inhibited, with activity increasing as substitution degree rises [A\/B]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/p>\n
How the permanent charge works [A]<\/h3>\n\n- Electrostatic binding to negatively charged cell envelopes.<\/li>\n
- Increased cell-wall permeability (alkaline phosphatase leakage).<\/li>\n
- Disrupted membrane integrity\u2014visible pitting under SEM.<\/li>\n
- Inhibited respiratory metabolism and protein\/DNA synthesis.<\/li>\n<\/ul>\n
Gentle, film-forming antimicrobial support for leave-on systems. Position it as preservative-boosting support; actual in-formula performance must be confirmed by preservative challenge testing.<\/p>\n
Sources: [A] Gao et al., Molecules 2024 (N-2-HACC against S. mutans; MIC\/SEM\/biofilm); [B] Wang et al., Int. J. Biol. Macromol. 2024 (chitosan quaternary ammonium salts; E. coli\/S. aureus).<\/p>\n
09 \u00b7 SAFETY AND MILDNESS<\/p>\n
Cationic performance without the baggage<\/h2>\n
ChitoQ carries its charge on a high-molecular-weight polysaccharide backbone\u2014it stays on the surface where it works, rather than penetrating like a small-molecule quaternary ammonium salt.<\/p>\n
No cytotoxicity in cell testing [A]<\/h3>\n
HACC-based derivatives showed no significant toxicity toward L929 fibroblasts; independent literature describes N-2-HACC as having very low toxicity and high safety.<\/p>\n
Bio-based and biodegradable [A\/C]<\/h3>\n
The marine-derived polysaccharide backbone addresses sustainability and environmental-persistence concerns associated with traditional synthetic cationic polymers.<\/p>\n
Built-in antioxidant benefit [A]<\/h3>\n
Beyond conditioning, HACC derivatives show free-radical scavenging activity (DPPH and superoxide anion).<\/p>\n
A high-molecular-weight cationic biopolymer designed for surface action. Finished-formula suitability and regulatory compliance remain the responsibility of the product developer; a complete toxicology dossier is available upon request.<\/p>\n
Sources: Han et al., Int. J. Biol. Macromol. 2024 (L929 cytotoxicity and antioxidant assays); Gao et al., Molecules 2024; Processes 2026 review (limitations of cationic systems).<\/p>\n
10 \u00b7 HAIR + SCALP SYNERGY<\/p>\n
One functional biopolymer\u2014two cosmetic interfaces<\/h2>\n
<\/p>\n
Hair fibre<\/h3>\n\n- Targeted deposition [B]:<\/b> cationic chains anchor to negatively charged damaged keratin sites.<\/li>\n
- Cuticle smoothing [C]:<\/b> the adsorbed film lays raised cuticles flat and reduces inter-fibre friction.<\/li>\n
- Anti-static control [C]:<\/b> charge neutralization tames static and humidity-induced frizz.<\/li>\n
- Protective conditioning layer [B]:<\/b> the affinity polymer film helps protect hair from daily mechanical damage.<\/li>\n<\/ul>\n
Scalp<\/h3>\n\n- Moisture management [B]:<\/b> the humectant polysaccharide film helps retain water at the scalp surface.<\/li>\n
- Surface comfort film [C]:<\/b> an ultra-thin polymer layer provides a smooth, protected skin feel.<\/li>\n
- Microenvironment support [A]:<\/b> demonstrated antimicrobial activity supports scalp-care concepts.<\/li>\n
- Formulation support [A]:<\/b> water-phase compatibility simplifies scalp lotions, essences, and cleansing formulas.<\/li>\n<\/ul>\n
The charge-affinity mechanism that conditions hair also serves the skin where hair grows.<\/p>\n
See the evidence section for grading. Sources: Gao et al., Molecules 2024 [A]; Mi et al., Polymers 2021 [B]; US 4,772,689 [B].<\/p>\n
11 \u00b7 PERFORMANCE ARCHITECTURE<\/p>\n
One polymer, six cosmetic functions.<\/h2>\n01 CONDITION | Affinity cationic deposition<\/h3>\n
Permanent charge anchors the polymer to hair keratin and skin surfaces for rinse-resistant conditioning. [B]<\/p>\n
02 SMOOTH | Film-forming surface refinement<\/h3>\n
An ultra-thin adsorbed film smooths cuticles and skin microrelief, reducing friction and roughness. [C]<\/p>\n
03 HYDRATE | Water retention and binding<\/h3>\n
The hydrophilic polysaccharide structure binds water, with moisturization benchmarked against hyaluronic acid. [B]<\/p>\n
04 PROTECT | Polymer protective interface<\/h3>\n
The deposited layer buffers hair fibres and skin surfaces against mechanical and environmental stress. [C]<\/p>\n
05 CONTROL | Anti-static and manageability<\/h3>\n
Charge neutralization reduces static and makes wet and dry combing easier. [C]<\/p>\n
06 SUPPORT | Skin and scalp-care functions<\/h3>\n
Demonstrated antimicrobial and moisturizing activity extends care from hair fibres to scalp and skin. [A]<\/p>\n
Molecule \u2192 mechanism \u2192 performance \u2192 formulation \u2192 consumer benefit<\/p>\n
The functional portfolio is limited to scientifically supported roles; see the evidence section for grading.<\/p>\n
12 \u00b7 APPLICATION OPPORTUNITIES<\/p>\n
One ingredient, two care categories<\/h2>\nHair and scalp<\/h3>\n\n- Conditioning shampoos\u2014deposition without build-up; compatible with amphoteric surfactant systems.<\/li>\n
- Rinse-off conditioners and masks\u2014wet-combing slip, cuticle sealing, and shine.<\/li>\n
- Leave-on anti-frizz serums\/sprays\u2014an anti-static film with humidity resistance.<\/li>\n
- Scalp lotions\u2014moisturization plus microbial-balance support.<\/li>\n
- Color-care systems\u2014film protection against wash-out and UV fading.<\/li>\n<\/ul>\n
Face and body<\/h3>\n\n- Moisturizing serums\/essences\u2014hyaluronic-acid-level hydration with a perceptibly cushioned skin feel.<\/li>\n
- Moisturizers and barrier creams\u2014a breathable film that slows water loss.<\/li>\n
- Sheet-mask essences\u2014affinity hydration that lasts after mask removal.<\/li>\n
- Facial mists\/toners\u2014water-clear and non-tacky.<\/li>\n
- Gentle cleansers\u2014a conditioned after-feel with a microbial-support story.<\/li>\n<\/ul>\n
Every concept inherits the same trio: affinity deposition \u00b7 moisturization \u00b7 microbial support<\/p>\n
Concept directions are provided for development reference only; prototype formulas are available from the Puripharm application laboratory.<\/p>\n
13 \u00b7 FORMULATION GUIDE<\/p>\n
Born for the water phase<\/h2>\n
\n\n\nParameter<\/th>\n Guidance<\/th>\n<\/tr>\n \nINCI \/ form<\/td>\n Chitosan Hydroxypropyltrimonium Chloride\u2014off-white powder<\/td>\n<\/tr>\n \nUse level<\/td>\n Varies by dosage form\u2014the Puripharm application laboratory provides system-specific starting recommendations<\/td>\n<\/tr>\n \nSolubility<\/td>\n Readily soluble in water across a broad pH window\u2014no acidification required<\/td>\n<\/tr>\n \nWorking pH<\/td>\n Functional pH 3\u201310; comfortable formulation range pH 4\u20138<\/td>\n<\/tr>\n \nAddition<\/td>\n Disperse in the water phase under moderate stirring until clear<\/td>\n<\/tr>\n \nCompatibility<\/td>\n Cationic\u2014avoid strongly anionic surfactants\/polymers; best paired with nonionic and amphoteric systems<\/td>\n<\/tr>\n \nProcess tolerance<\/td>\n The polysaccharide backbone is stable; add below 80 \u00b0C to protect color and viscosity<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nFormulator notes<\/h3>\n\n- Rinse-off products: deposit first, rinse second\u2014affinity withstands dilution.<\/li>\n
- Screen salts\u2014high ionic strength compresses charge interactions.<\/li>\n
- Brings light, elegant viscosity to aqueous systems.<\/li>\n
- Pair with humectants (glycerin, betaine, PCA) to strengthen the hydration story.<\/li>\n
- Confirm preservative synergy in the final base through challenge testing.<\/li>\n<\/ul>\n
Prototype formulas (conditioning shampoo, moisturizing serum, and scalp lotion) are available from the Puripharm application laboratory.<\/p>\n
Guidance is based on published physicochemical behavior of quaternized chitosan and Puripharm application experience; validate in the final formula.<\/p>\n
14 \u00b7 DIFFERENTIATION<\/p>\n
A bio-based answer to synthetic cationic polymers<\/h2>\n
\n\n\nDimension<\/th>\n PURIACTIVES\u00ae CHITOQ<\/th>\n Native chitosan<\/th>\n Synthetic polyquaterniums<\/th>\n<\/tr>\n \nSource<\/td>\n Marine-derived, bio-based<\/td>\n Marine-derived, bio-based<\/td>\n Petrochemical<\/td>\n<\/tr>\n \nCharge vs pH<\/td>\n Permanently cationic, pH 3\u201310<\/td>\n Only below pKa \u2248 6.5<\/td>\n Permanently cationic<\/td>\n<\/tr>\n \nWater compatibility<\/td>\n Direct dissolution, no acidification<\/td>\n Acidic media only<\/td>\n Good<\/td>\n<\/tr>\n \nAffinity<\/td>\n High\u2014keratin and skin<\/td>\n Moderate, pH-limited<\/td>\n High<\/td>\n<\/tr>\n \nMultifunctionality<\/td>\n Conditioning + moisturization + antimicrobial support<\/td>\n Film-forming and moisturizing<\/td>\n Conditioning only<\/td>\n<\/tr>\n \nEnd of life<\/td>\n Biodegradable polysaccharide<\/td>\n Biodegradable<\/td>\n Persistence concern<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nSynthetic-grade performance with a biopolymer story\u2014without naming any commercial competitor.<\/p>\n
15 \u00b7 QUALITY AND REGULATORY<\/p>\n
Batch traceability\u2014all 11 tests passed<\/h2>\nSpecification vs representative production batch<\/h3>\n
\n\n\nTest item<\/th>\n Specification<\/th>\n Batch result<\/th>\n<\/tr>\n \nAppearance<\/td>\n Off-white powder<\/td>\n Complies<\/td>\n<\/tr>\n \nSolubility<\/td>\n Soluble in deionized water<\/td>\n Complies<\/td>\n<\/tr>\n \nMoisture<\/td>\n \u2264 10.0%<\/td>\n 8.7%<\/td>\n<\/tr>\n \nAsh<\/td>\n \u2264 1.0%<\/td>\n 0.45%<\/td>\n<\/tr>\n \npH (1% solution)<\/td>\n 5.5\u20137.5<\/td>\n 6.41<\/td>\n<\/tr>\n \nViscosity (1% aqueous solution, 20 \u00b0C)<\/td>\n Meets product claim<\/td>\n 18 mPa\u00b7s<\/td>\n<\/tr>\n \nDegree of deacetylation<\/td>\n \u2265 85.0%<\/td>\n 89.2%<\/td>\n<\/tr>\n \nDegree of substitution<\/td>\n \u2265 80.0%<\/td>\n 98.5%<\/td>\n<\/tr>\n \nArsenic (As)<\/td>\n \u2264 4.0 mg\/kg<\/td>\n Not detected (< 0.01)<\/td>\n<\/tr>\n \nLead (Pb)<\/td>\n \u2264 2.0 mg\/kg<\/td>\n Not detected (< 0.02)<\/td>\n<\/tr>\n \nWater-insoluble matter<\/td>\n \u2264 0.5%<\/td>\n 0.03%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n11 \/ 11All quality tests passed for the current production batch<\/td>\n 98.5%Degree of substitution; specification \u2265 80%<\/td>\n NDArsenic and lead below detection limits (< 0.01 \/ < 0.02 mg\/kg)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nRegulatory identity<\/h3>\n
The INCI name Chitosan Hydroxypropyltrimonium Chloride is listed in the EU CosIng database with hair-conditioning and humectant functions. Each batch is supplied with COA, TDS, and SDS.<\/p>\n
Puripharm Co., Ltd. batch inspection report (May 2026); complete COA, TDS, and SDS are available upon request. EU CosIng listed functions: hair conditioning and humectant.<\/p>\n
16 \u00b7 SUMMARY<\/p>\n
ChitoQ earns a place in your formula<\/h2>\n
Marine chitosan backbone \u2192 functional quaternization \u2192 water compatibility + permanent charge \u2192 biological surface binding \u2192 multifunctional performance<\/p>\n
No more formulation compromise<\/h3>\n
Water compatibility across pH 3\u201310 ends the acidic-system constraint of native chitosan.<\/p>\n
Performance that stays<\/h3>\n
Permanent cationic affinity delivers rinse-resistant conditioning and moisturization.<\/p>\n
A cleaner label story<\/h3>\n
Bio-based, biodegradable, and clean in cell testing\u2014a credible successor to synthetic polyquaterniums.<\/p>\n
Honestly graded evidence<\/h3>\n
ChitoQ-specific data lead the story; related quaternized-chitosan and chitosan literature is clearly labeled.<\/p>\n
One SKU, three functions<\/h3>\n
Conditioning, moisturization, and antimicrobial support simplify formulas and strengthen claims.<\/p>\n
End-to-end support<\/h3>\n
Specifications, dossiers, and prototype formulas travel with the ingredient\u2014not as an afterthought.<\/p>\n
ChitoQ turns an exceptional biopolymer into a reliable formulation tool.<\/p>\n
<\/p>\n
PURIPHARM CO., LTD.<\/p>\n
Let\u2019s build the next generation of care products together.<\/h2>\n
Request PuriActives\u00ae ChitoQ samples, specifications, safety dossiers, and prototype formulas.<\/p>\n
\n\n\nWebsite<\/td>\n www.puriactives.com<\/td>\n<\/tr>\n \nEmail<\/td>\n service@puripharm.com<\/td>\n<\/tr>\n \nPhone<\/td>\n +86-572-2745768<\/td>\n<\/tr>\n \nAddress<\/td>\n Building 6, No. 1366 Hongfeng Road, Huzhou, Zhejiang, China<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nPuriActives\u00ae and ChitoQ\u00ae are registered trademarks of Puripharm Co., Ltd. This presentation introduces a cosmetic ingredient only and contains no drug claims. In vitro and third-party literature data are identified and do not represent clinical performance of finished products.<\/p>\n","protected":false},"excerpt":{"rendered":"
PuriActives\u00ae ChitoQ INCI: Chitosan Hydroxypropyltrimoni […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[35,27],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1404"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1404"}],"version-history":[{"count":1,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1404\/revisions"}],"predecessor-version":[{"id":1405,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1404\/revisions\/1405"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1404"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/p>\n
Sources: chitosan pKa and pH-dependent charge\u2014J. Mater. Chem. B 2023; ACS Appl. Mater. Interfaces 2023.<\/p>\n
02 \u00b7 PRODUCT OVERVIEW<\/p>\n
One molecule, two care categories.<\/h2>\n
PuriActives\u00ae ChitoQ is a quaternized chitosan: a marine-derived polysaccharide carrying permanent quaternary ammonium groups. It is water-compatible, permanently cationic, and multifunctional for both leave-on and rinse-off systems.<\/p>\n
- \n
- Cationic affinity deposition on hair keratin and skin surfaces.<\/li>\n
- Conditioning, cuticle smoothing, and anti-static performance.<\/li>\n
- Moisturization benchmarked against hyaluronic acid.<\/li>\n
- Broad-spectrum antimicrobial and anti-biofilm support.<\/li>\n
- A bio-based, biodegradable alternative to synthetic polyquaterniums.<\/li>\n<\/ul>\n<\/p>\n
\n\n
\n pH 3\u201310Maintains permanent cationic character across the formulation pH window<\/td>\n 0.625 mg\/mLMIC against Streptococcus mutans\u201490% growth inhibition in vitro<\/td>\n<\/tr>\n \n 98.5%Degree of substitution in the current batch (specification \u2265 80%)<\/td>\n CosIngEU-listed INCI\u2014functions: hair conditioning and humectant<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Sources: Gao et al., Molecules 2024 (S. mutans, in vitro); EU CosIng database; Puripharm batch COA (May 2026).<\/p>\n
03 \u00b7 MOLECULAR DESIGN<\/p>\n
From chitosan to ChitoQ: functional quaternization<\/h2>\n
<\/p>\nPermanent cationic charge<\/h3>\n
Quaternary ammonium groups never deprotonate, preserving charge across the full cosmetic pH range.<\/p>\n
True water compatibility<\/h3>\n
It dissolves directly in water without acidification\u2014add it to the water phase and formulate freely.<\/p>\n
Stronger surface affinity<\/h3>\n
Electrostatic binding to anionic keratin and skin surfaces drives affinity deposition and film formation.<\/p>\n
The quaternization route follows the published synthesis of N-2-hydroxypropyltrimethylammonium chloride chitosan (Gao et al., Molecules 2024).<\/p>\n
04 \u00b7 PHYSICOCHEMICAL PROPERTIES<\/p>\n
Positive charge at any formulation pH<\/h2>\n
<\/p>\nUnconditional charge<\/h3>\n
Quaternary ammonium groups remain protonated from acidic to weakly alkaline media\u2014affinity deposition no longer depends on pH.<\/p>\n
Soluble where chitosan is not<\/h3>\n
High-substitution HACC forms clear aqueous solutions (transmittance >80% at 80% substitution)\u2014no acidification or pre-dissolution required.<\/p>\n
Built for deposition<\/h3>\n
High permanent charge density maximizes electrostatic interaction with anionic keratin and skin\u2014the physical basis for conditioning and film formation.<\/p>\n
Sources: ACS Appl. Mater. Interfaces 2023 (zeta potential of quaternized chitosan, pH 3\u201310); ACS Omega 2021 (QCS charge retention); Gao et al., Molecules 2024 (solubility).<\/p>\n
05 \u00b7 MECHANISM OF ACTION<\/p>\n
Designed to bind precisely where damage occurs<\/h2>\n
<\/p>\n- \n
- Selective attraction:<\/b> the isoelectric point of hair keratin is approximately 3.67. At cosmetic pH, hair carries a net negative charge, and damaged fibres are even more negatively charged.<\/li>\n
- Cationic deposition:<\/b> ChitoQ adsorbs to anionic sites through electrostatic interaction, concentrating deposition where the fibre needs it most and resisting rinse-off.<\/li>\n
- Conditioning film:<\/b> the bound polymer forms a smooth, hydrophilic film that lays cuticles flat, reduces friction and static, and helps retain surface moisture.<\/li>\n<\/ol>\n
The same physical mechanism works on skin: an affinity, breathable cationic film binds water and supports the surface barrier\u2014one mechanism, two categories.<\/p>\n
Source: hair isoelectric point and cationic deposition mechanism\u2014Gavazzoni Dias et al., On Hair Care Physicochemistry, Int. J. Trichology \/ PMC9921463.<\/p>\n
<\/p>\nEVIDENCE SECTION<\/p>\n
Performance evidence<\/h2>\n
Quantified results from peer-reviewed research on ChitoQ chemistry, presented with transparent evidence grading.<\/p>\n
A<\/b> | Studies on ChitoQ chemistry itself (Chitosan Hydroxypropyltrimonium Chloride)<\/p>\n
B<\/b> | Structurally similar quaternized chitosan\u2014mechanistic support<\/p>\n
C<\/b> | General chitosan literature\u2014physicochemical background<\/p>\n
06 \u00b7 HAIR-CARE PERFORMANCE<\/p>\n
Affinity conditioning beyond rinse-off<\/h2>\n
A cationic film restores surface smoothness and shine.<\/p>\n
Targeted deposition on damaged keratin [B]<\/h3>\n
The affinity of quaternized chitosan for hair keratin has been demonstrated, and its strengthening and conditioning effects have been documented since the earliest quaternized-chitosan patents.<\/p>\n
Easier wet and dry combing [C]<\/h3>\n
The adsorbed film reduces inter-fibre friction, helps detangling, and reduces mechanical breakage during combing.<\/p>\n
Anti-static and frizz control [C]<\/h3>\n
Charge neutralization plus a smoothing film minimizes static and seals cuticles against humidity-induced frizz.<\/p>\n
Shine, softness, and color protection [C]<\/h3>\n
Flat cuticles reflect light evenly, while the protective film helps color resist washing and UV exposure.<\/p>\n
Added scalp-care benefit [A]<\/h3>\n
Demonstrated antimicrobial activity extends the benefit from the hair fibre to the scalp environment.<\/p>\n
Damaged hair has a lower isoelectric point and a denser negative surface charge, so cationic polymers deposit preferentially where repair is most needed.<\/p>\n
Sources: US 4,772,689 (Lang et al., quaternized-chitosan affinity); PCACD 2024 review (chitosan hair care); Gao et al., Molecules 2024. See the evidence section for [A]\/[B]\/[C] grading.<\/p>\n
07 \u00b7 SKIN-CARE PERFORMANCE<\/p>\n
Hyaluronic-acid-level moisturization<\/h2>\n
<\/p>\n[A] HACC performs within the hyaluronic-acid range, and its ion-exchange derivative can reach 2.2\u00d7 HA. At 43% RH, the HACC derivative also absorbed more moisture than HA (74\u201394% vs 32.4%, 48 h).<\/p>\n
Dual water management<\/h3>\n
A surface rich in hydroxyl and quaternary ammonium groups binds water through hydrogen bonding, while the affinity film helps slow transepidermal water loss. [A\/C]<\/p>\n
Breathable barrier support<\/h3>\n
Chitosan films are non-occlusive: they buffer the stratum corneum against environmental stress while allowing skin to function normally. [C]<\/p>\n
Sensory differentiation<\/h3>\n
The cationic film provides a distinctive smooth, cushioned after-feel\u2014a humectant consumers can actually perceive. [C]<\/p>\n
Sources: Mi et al., Polymers 2021 (PMC8307204)\u2014in vitro comparison of moisture absorption\/retention by HACC, its derivatives, and sodium hyaluronate; chitosan film\/TEWL literature (PCACD 2024).<\/p>\n
08 \u00b7 ANTIMICROBIAL SUPPORT<\/p>\n
A cationic mechanism acting on microbial surfaces<\/h2>\n
\n\n
\n 0.625 mg\/mLMIC of N-2-HACC against S. mutans; 90.0% growth inhibition at the MIC [A]<\/td>\n > 90%Inhibition of E. coli and S. aureus by quaternized chitosan salts at 0.5 mg\/mL [B]<\/td>\n BiofilmFormation is significantly inhibited, with activity increasing as substitution degree rises [A\/B]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\nHow the permanent charge works [A]<\/h3>\n
- \n
- Electrostatic binding to negatively charged cell envelopes.<\/li>\n
- Increased cell-wall permeability (alkaline phosphatase leakage).<\/li>\n
- Disrupted membrane integrity\u2014visible pitting under SEM.<\/li>\n
- Inhibited respiratory metabolism and protein\/DNA synthesis.<\/li>\n<\/ul>\n
Gentle, film-forming antimicrobial support for leave-on systems. Position it as preservative-boosting support; actual in-formula performance must be confirmed by preservative challenge testing.<\/p>\n
Sources: [A] Gao et al., Molecules 2024 (N-2-HACC against S. mutans; MIC\/SEM\/biofilm); [B] Wang et al., Int. J. Biol. Macromol. 2024 (chitosan quaternary ammonium salts; E. coli\/S. aureus).<\/p>\n
09 \u00b7 SAFETY AND MILDNESS<\/p>\n
Cationic performance without the baggage<\/h2>\n
ChitoQ carries its charge on a high-molecular-weight polysaccharide backbone\u2014it stays on the surface where it works, rather than penetrating like a small-molecule quaternary ammonium salt.<\/p>\n
No cytotoxicity in cell testing [A]<\/h3>\n
HACC-based derivatives showed no significant toxicity toward L929 fibroblasts; independent literature describes N-2-HACC as having very low toxicity and high safety.<\/p>\n
Bio-based and biodegradable [A\/C]<\/h3>\n
The marine-derived polysaccharide backbone addresses sustainability and environmental-persistence concerns associated with traditional synthetic cationic polymers.<\/p>\n
Built-in antioxidant benefit [A]<\/h3>\n
Beyond conditioning, HACC derivatives show free-radical scavenging activity (DPPH and superoxide anion).<\/p>\n
A high-molecular-weight cationic biopolymer designed for surface action. Finished-formula suitability and regulatory compliance remain the responsibility of the product developer; a complete toxicology dossier is available upon request.<\/p>\n
Sources: Han et al., Int. J. Biol. Macromol. 2024 (L929 cytotoxicity and antioxidant assays); Gao et al., Molecules 2024; Processes 2026 review (limitations of cationic systems).<\/p>\n
10 \u00b7 HAIR + SCALP SYNERGY<\/p>\n
One functional biopolymer\u2014two cosmetic interfaces<\/h2>\n
<\/p>\nHair fibre<\/h3>\n
- \n
- Targeted deposition [B]:<\/b> cationic chains anchor to negatively charged damaged keratin sites.<\/li>\n
- Cuticle smoothing [C]:<\/b> the adsorbed film lays raised cuticles flat and reduces inter-fibre friction.<\/li>\n
- Anti-static control [C]:<\/b> charge neutralization tames static and humidity-induced frizz.<\/li>\n
- Protective conditioning layer [B]:<\/b> the affinity polymer film helps protect hair from daily mechanical damage.<\/li>\n<\/ul>\n
Scalp<\/h3>\n
- \n
- Moisture management [B]:<\/b> the humectant polysaccharide film helps retain water at the scalp surface.<\/li>\n
- Surface comfort film [C]:<\/b> an ultra-thin polymer layer provides a smooth, protected skin feel.<\/li>\n
- Microenvironment support [A]:<\/b> demonstrated antimicrobial activity supports scalp-care concepts.<\/li>\n
- Formulation support [A]:<\/b> water-phase compatibility simplifies scalp lotions, essences, and cleansing formulas.<\/li>\n<\/ul>\n
The charge-affinity mechanism that conditions hair also serves the skin where hair grows.<\/p>\n
See the evidence section for grading. Sources: Gao et al., Molecules 2024 [A]; Mi et al., Polymers 2021 [B]; US 4,772,689 [B].<\/p>\n
11 \u00b7 PERFORMANCE ARCHITECTURE<\/p>\n
One polymer, six cosmetic functions.<\/h2>\n
01 CONDITION | Affinity cationic deposition<\/h3>\n
Permanent charge anchors the polymer to hair keratin and skin surfaces for rinse-resistant conditioning. [B]<\/p>\n
02 SMOOTH | Film-forming surface refinement<\/h3>\n
An ultra-thin adsorbed film smooths cuticles and skin microrelief, reducing friction and roughness. [C]<\/p>\n
03 HYDRATE | Water retention and binding<\/h3>\n
The hydrophilic polysaccharide structure binds water, with moisturization benchmarked against hyaluronic acid. [B]<\/p>\n
04 PROTECT | Polymer protective interface<\/h3>\n
The deposited layer buffers hair fibres and skin surfaces against mechanical and environmental stress. [C]<\/p>\n
05 CONTROL | Anti-static and manageability<\/h3>\n
Charge neutralization reduces static and makes wet and dry combing easier. [C]<\/p>\n
06 SUPPORT | Skin and scalp-care functions<\/h3>\n
Demonstrated antimicrobial and moisturizing activity extends care from hair fibres to scalp and skin. [A]<\/p>\n
Molecule \u2192 mechanism \u2192 performance \u2192 formulation \u2192 consumer benefit<\/p>\n
The functional portfolio is limited to scientifically supported roles; see the evidence section for grading.<\/p>\n
12 \u00b7 APPLICATION OPPORTUNITIES<\/p>\n
One ingredient, two care categories<\/h2>\n
Hair and scalp<\/h3>\n
- \n
- Conditioning shampoos\u2014deposition without build-up; compatible with amphoteric surfactant systems.<\/li>\n
- Rinse-off conditioners and masks\u2014wet-combing slip, cuticle sealing, and shine.<\/li>\n
- Leave-on anti-frizz serums\/sprays\u2014an anti-static film with humidity resistance.<\/li>\n
- Scalp lotions\u2014moisturization plus microbial-balance support.<\/li>\n
- Color-care systems\u2014film protection against wash-out and UV fading.<\/li>\n<\/ul>\n
Face and body<\/h3>\n
- \n
- Moisturizing serums\/essences\u2014hyaluronic-acid-level hydration with a perceptibly cushioned skin feel.<\/li>\n
- Moisturizers and barrier creams\u2014a breathable film that slows water loss.<\/li>\n
- Sheet-mask essences\u2014affinity hydration that lasts after mask removal.<\/li>\n
- Facial mists\/toners\u2014water-clear and non-tacky.<\/li>\n
- Gentle cleansers\u2014a conditioned after-feel with a microbial-support story.<\/li>\n<\/ul>\n
Every concept inherits the same trio: affinity deposition \u00b7 moisturization \u00b7 microbial support<\/p>\n
Concept directions are provided for development reference only; prototype formulas are available from the Puripharm application laboratory.<\/p>\n
13 \u00b7 FORMULATION GUIDE<\/p>\n
Born for the water phase<\/h2>\n
\n\n
\n Parameter<\/th>\n Guidance<\/th>\n<\/tr>\n \n INCI \/ form<\/td>\n Chitosan Hydroxypropyltrimonium Chloride\u2014off-white powder<\/td>\n<\/tr>\n \n Use level<\/td>\n Varies by dosage form\u2014the Puripharm application laboratory provides system-specific starting recommendations<\/td>\n<\/tr>\n \n Solubility<\/td>\n Readily soluble in water across a broad pH window\u2014no acidification required<\/td>\n<\/tr>\n \n Working pH<\/td>\n Functional pH 3\u201310; comfortable formulation range pH 4\u20138<\/td>\n<\/tr>\n \n Addition<\/td>\n Disperse in the water phase under moderate stirring until clear<\/td>\n<\/tr>\n \n Compatibility<\/td>\n Cationic\u2014avoid strongly anionic surfactants\/polymers; best paired with nonionic and amphoteric systems<\/td>\n<\/tr>\n \n Process tolerance<\/td>\n The polysaccharide backbone is stable; add below 80 \u00b0C to protect color and viscosity<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Formulator notes<\/h3>\n
- \n
- Rinse-off products: deposit first, rinse second\u2014affinity withstands dilution.<\/li>\n
- Screen salts\u2014high ionic strength compresses charge interactions.<\/li>\n
- Brings light, elegant viscosity to aqueous systems.<\/li>\n
- Pair with humectants (glycerin, betaine, PCA) to strengthen the hydration story.<\/li>\n
- Confirm preservative synergy in the final base through challenge testing.<\/li>\n<\/ul>\n
Prototype formulas (conditioning shampoo, moisturizing serum, and scalp lotion) are available from the Puripharm application laboratory.<\/p>\n
Guidance is based on published physicochemical behavior of quaternized chitosan and Puripharm application experience; validate in the final formula.<\/p>\n
14 \u00b7 DIFFERENTIATION<\/p>\n
A bio-based answer to synthetic cationic polymers<\/h2>\n
\n\n
\n Dimension<\/th>\n PURIACTIVES\u00ae CHITOQ<\/th>\n Native chitosan<\/th>\n Synthetic polyquaterniums<\/th>\n<\/tr>\n \n Source<\/td>\n Marine-derived, bio-based<\/td>\n Marine-derived, bio-based<\/td>\n Petrochemical<\/td>\n<\/tr>\n \n Charge vs pH<\/td>\n Permanently cationic, pH 3\u201310<\/td>\n Only below pKa \u2248 6.5<\/td>\n Permanently cationic<\/td>\n<\/tr>\n \n Water compatibility<\/td>\n Direct dissolution, no acidification<\/td>\n Acidic media only<\/td>\n Good<\/td>\n<\/tr>\n \n Affinity<\/td>\n High\u2014keratin and skin<\/td>\n Moderate, pH-limited<\/td>\n High<\/td>\n<\/tr>\n \n Multifunctionality<\/td>\n Conditioning + moisturization + antimicrobial support<\/td>\n Film-forming and moisturizing<\/td>\n Conditioning only<\/td>\n<\/tr>\n \n End of life<\/td>\n Biodegradable polysaccharide<\/td>\n Biodegradable<\/td>\n Persistence concern<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Synthetic-grade performance with a biopolymer story\u2014without naming any commercial competitor.<\/p>\n
15 \u00b7 QUALITY AND REGULATORY<\/p>\n
Batch traceability\u2014all 11 tests passed<\/h2>\n
Specification vs representative production batch<\/h3>\n
\n\n
\n Test item<\/th>\n Specification<\/th>\n Batch result<\/th>\n<\/tr>\n \n Appearance<\/td>\n Off-white powder<\/td>\n Complies<\/td>\n<\/tr>\n \n Solubility<\/td>\n Soluble in deionized water<\/td>\n Complies<\/td>\n<\/tr>\n \n Moisture<\/td>\n \u2264 10.0%<\/td>\n 8.7%<\/td>\n<\/tr>\n \n Ash<\/td>\n \u2264 1.0%<\/td>\n 0.45%<\/td>\n<\/tr>\n \n pH (1% solution)<\/td>\n 5.5\u20137.5<\/td>\n 6.41<\/td>\n<\/tr>\n \n Viscosity (1% aqueous solution, 20 \u00b0C)<\/td>\n Meets product claim<\/td>\n 18 mPa\u00b7s<\/td>\n<\/tr>\n \n Degree of deacetylation<\/td>\n \u2265 85.0%<\/td>\n 89.2%<\/td>\n<\/tr>\n \n Degree of substitution<\/td>\n \u2265 80.0%<\/td>\n 98.5%<\/td>\n<\/tr>\n \n Arsenic (As)<\/td>\n \u2264 4.0 mg\/kg<\/td>\n Not detected (< 0.01)<\/td>\n<\/tr>\n \n Lead (Pb)<\/td>\n \u2264 2.0 mg\/kg<\/td>\n Not detected (< 0.02)<\/td>\n<\/tr>\n \n Water-insoluble matter<\/td>\n \u2264 0.5%<\/td>\n 0.03%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\n
\n 11 \/ 11All quality tests passed for the current production batch<\/td>\n 98.5%Degree of substitution; specification \u2265 80%<\/td>\n NDArsenic and lead below detection limits (< 0.01 \/ < 0.02 mg\/kg)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Regulatory identity<\/h3>\n
The INCI name Chitosan Hydroxypropyltrimonium Chloride is listed in the EU CosIng database with hair-conditioning and humectant functions. Each batch is supplied with COA, TDS, and SDS.<\/p>\n
Puripharm Co., Ltd. batch inspection report (May 2026); complete COA, TDS, and SDS are available upon request. EU CosIng listed functions: hair conditioning and humectant.<\/p>\n
16 \u00b7 SUMMARY<\/p>\n
ChitoQ earns a place in your formula<\/h2>\n
Marine chitosan backbone \u2192 functional quaternization \u2192 water compatibility + permanent charge \u2192 biological surface binding \u2192 multifunctional performance<\/p>\n
No more formulation compromise<\/h3>\n
Water compatibility across pH 3\u201310 ends the acidic-system constraint of native chitosan.<\/p>\n
Performance that stays<\/h3>\n
Permanent cationic affinity delivers rinse-resistant conditioning and moisturization.<\/p>\n
A cleaner label story<\/h3>\n
Bio-based, biodegradable, and clean in cell testing\u2014a credible successor to synthetic polyquaterniums.<\/p>\n
Honestly graded evidence<\/h3>\n
ChitoQ-specific data lead the story; related quaternized-chitosan and chitosan literature is clearly labeled.<\/p>\n
One SKU, three functions<\/h3>\n
Conditioning, moisturization, and antimicrobial support simplify formulas and strengthen claims.<\/p>\n
End-to-end support<\/h3>\n
Specifications, dossiers, and prototype formulas travel with the ingredient\u2014not as an afterthought.<\/p>\n
ChitoQ turns an exceptional biopolymer into a reliable formulation tool.<\/p>\n
<\/p>\nPURIPHARM CO., LTD.<\/p>\n
Let\u2019s build the next generation of care products together.<\/h2>\n
Request PuriActives\u00ae ChitoQ samples, specifications, safety dossiers, and prototype formulas.<\/p>\n
\n\n
\n Website<\/td>\n www.puriactives.com<\/td>\n<\/tr>\n \n Email<\/td>\n service@puripharm.com<\/td>\n<\/tr>\n \n Phone<\/td>\n +86-572-2745768<\/td>\n<\/tr>\n \n Address<\/td>\n Building 6, No. 1366 Hongfeng Road, Huzhou, Zhejiang, China<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n PuriActives\u00ae and ChitoQ\u00ae are registered trademarks of Puripharm Co., Ltd. This presentation introduces a cosmetic ingredient only and contains no drug claims. In vitro and third-party literature data are identified and do not represent clinical performance of finished products.<\/p>\n","protected":false},"excerpt":{"rendered":"
PuriActives\u00ae ChitoQ INCI: Chitosan Hydroxypropyltrimoni […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[35,27],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1404"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1404"}],"version-history":[{"count":1,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1404\/revisions"}],"predecessor-version":[{"id":1405,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1404\/revisions\/1405"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1404"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- Surface comfort film [C]:<\/b> an ultra-thin polymer layer provides a smooth, protected skin feel.<\/li>\n
- Cuticle smoothing [C]:<\/b> the adsorbed film lays raised cuticles flat and reduces inter-fibre friction.<\/li>\n
- Targeted deposition [B]:<\/b> cationic chains anchor to negatively charged damaged keratin sites.<\/li>\n
- Cationic deposition:<\/b> ChitoQ adsorbs to anionic sites through electrostatic interaction, concentrating deposition where the fibre needs it most and resisting rinse-off.<\/li>\n
- Selective attraction:<\/b> the isoelectric point of hair keratin is approximately 3.67. At cosmetic pH, hair carries a net negative charge, and damaged fibres are even more negatively charged.<\/li>\n