{"id":1406,"date":"2026-09-24T22:07:16","date_gmt":"2026-09-24T14:07:16","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=1406"},"modified":"2026-09-24T22:07:16","modified_gmt":"2026-09-24T14:07:16","slug":"puriactives-biofuco-powder","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=1406","title":{"rendered":"PuriActives\u00ae BioFuco&#x2122; Powder"},"content":{"rendered":"<h2>PuriActives\u00ae BioFuco&#x2122; Powder<\/h2>\n<p>A Microbiome-Friendly Prebiotic Powder Blend<\/p>\n<p>A tri-saccharide system for skin and scalp microbiome balance<\/p>\n<p>INCI: Biosaccharide Gum-1 \u00b7 Xylitol \u00b7 Lactitol<\/p>\n<p>Microbiome balance \u00b7 Barrier &amp; hydration \u00b7 Smart powder format<\/p>\n<p>Product Technology &amp; Market Introduction \u00b7 Cosmetic Active Ingredient<\/p>\n<p>01 \u00b7 SKIN ECOLOGY<\/p>\n<h2>The Next Logic of Skincare: Skin Is an Ecosystem<\/h2>\n<p>Skin is more than a physical barrier \u2014 it is an ecosystem built by microorganisms, sebum, water, and immune cells together. Resident flora occupy ecological niches, produce antimicrobial molecules, and \u201ceducate\u201d the immune system: they are the first \u201cliving line of defense\u201d of skin homeostasis.<\/p>\n<p>When the flora falls out of balance (dysbiosis), dryness, sensitivity, breakouts, and dandruff follow \u2014 the answer is to restore balance, not to eliminate indiscriminately.<\/p>\n<p><b>Dryness &amp; flaking \u00b7 Sensitivity &amp; redness \u00b7 Breakouts \u00b7 Dandruff<\/b>\u2014 all are scientifically linked to microbiome imbalance<\/p>\n<table data-draft-node=\"block\" data-draft-type=\"table\" data-size=\"normal\" data-row-style=\"normal\">\n<tbody>\n<tr>\n<td>106microorganisms \/ cm\u00b2Order of magnitude of microbial density on healthy skin<\/td>\n<td>\u22481,000bacterial species identified on human skinDiversity is closely tied to skin health<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Sources: Grice &amp; Segre, Nat Rev Microbiol, 2011; Byrd et al., Nat Rev Microbiol, 2018.<\/p>\n<p>02 \u00b7 WHY THE MICROBIOME<\/p>\n<h2>From \u201cKilling\u201d to \u201cNurturing\u201d: The Shift Toward Microbiome Balance<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-3ed65b763aa88b346676ef8ec12d70ab~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1790258379-0-0-91596edbafba10e3494a0e515cd4b5ba&amp;bizSceneCode=article_draft&amp;expiration=1790258379&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"594\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-3ed65b763aa88b346676ef8ec12d70ab~resize:0:q75.png?source=1f5c5e47&amp;expiration=1790261457&amp;auth_key=1790261457-0-0-b15a266521e0f085e64534a9cb3db8b9&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-ef574e68ed41aaad71fb5b4650f69909~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1790261458&amp;auth_key=1790261458-0-0-8bbdefce51c2ade5c511b5ad57379edf&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h3>Traditional Antimicrobial Logic\uff5cKILL THEM ALL<\/h3>\n<p>Broad-spectrum antimicrobials remove microbes indiscriminately; resident and pathogenic flora are damaged alike; the ecological vacuum lets pathogens rebound faster; barrier and flora homeostasis are repeatedly disrupted.<\/p>\n<h3>Microbiome Balance Logic\uff5cBALANCE THE ECOSYSTEM<\/h3>\n<p>Provide sugar substrates usable by resident flora; selectively limit pathogen adhesion and biofilms; restore the natural balance of niche competition; a better microenvironment builds a stronger barrier.<\/p>\n<p>Sources: Byrd et al., Nat Rev Microbiol, 2018; Katsuyama et al., J Dermatol Sci, 2005.<\/p>\n<p>03 \u00b7 PRODUCT CONCEPT<\/p>\n<h2>BioFuco&#x2122; Powder: A Tri-Saccharide Prebiotic Active<\/h2>\n<h3>Biosaccharide Gum-1\uff5cA Fucose-Rich Polysaccharide<\/h3>\n<p>A fermentation-derived polysaccharide. Film-forming water lock for lasting hydration; soothing and skin-friendly with high skin affinity; enhances formulation sensory feel.<\/p>\n<h3>Xylitol\uff5cA Prebiotic Five-Carbon Sugar Alcohol<\/h3>\n<p>A prebiotic pentitol. A selective substrate for resident flora; upregulates filaggrin to support the barrier; limits pathogen adhesion and biofilm formation.<\/p>\n<h3>Lactitol\uff5cA Prebiotic Disaccharide Alcohol<\/h3>\n<p>A prebiotic disaccharide polyol. Selectively utilized by beneficial bacteria; a multi-hydroxyl hydrating structure; improves scalp and skin comfort.<\/p>\n<p>Polysaccharide network \u00d7 prebiotic sugar alcohols \u00d7 microbiome modulation \u2014 not a simple blend, but a synergistic active system designed around the skin ecosystem.<\/p>\n<table data-draft-node=\"block\" data-draft-type=\"table\" data-size=\"normal\" data-row-style=\"normal\">\n<tbody>\n<tr>\n<td>PositioningMicrobiome-friendly activePrebiotic skin-conditioning system<\/td>\n<td>Technical ProfileFermentation biotechnologyPreservative-free powder<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>04 \u00b7 SYNERGY SYSTEM<\/p>\n<h2>The Tri-Saccharide System: One Synergistic Eco-Active<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-46503f1840ce5403cc8b4595d98ce94e~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1790258379-0-0-0951c8161947a95273dc7b096b0fff3a&amp;bizSceneCode=article_draft&amp;expiration=1790258379&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"545\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-46503f1840ce5403cc8b4595d98ce94e~resize:0:q75.png?source=1f5c5e47&amp;expiration=1790261457&amp;auth_key=1790261457-0-0-24113014c01f742968ab66c8d863f86c&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-25f9f1fa18c86178c636ca2a1ba83abd~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1790261458&amp;auth_key=1790261458-0-0-7bd4706295be5d284c26878ddbfe0ce1&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h3>Microbiome Modulation<\/h3>\n<p>Selectively feeds resident flora while restraining opportunistic pathogens.<\/p>\n<h3>Barrier Support<\/h3>\n<p>Xylitol upregulates filaggrin and reduces TEWL.<\/p>\n<h3>Lasting Hydration<\/h3>\n<p>Film-forming + humectant sugars + endogenous NMF.<\/p>\n<h3>Soothing Comfort<\/h3>\n<p>The fucose-rich polysaccharide soothes sensitive, reactive skin.<\/p>\n<p>The synergy logic is based on published research evidence for each component; see the evidence page and source notes.<\/p>\n<p>05 \u00b7 PREBIOTIC MODULATION<\/p>\n<h2>Selective Prebiotics: Feed the Residents, Restrain the Opportunists<\/h2>\n<h3>Staphylococcus epidermidis<\/h3>\n<p>Resident flora \u00b7 produces antimicrobial peptides \u00b7 maintains homeostasis<\/p>\n<p><b>1% xylitol significantly promotes growth<\/b>; higher growth rate in pure culture (p &lt; 0.001).<\/p>\n<h3>Staphylococcus aureus<\/h3>\n<p>Opportunistic pathogen \u00b7 linked to atopic skin concerns \u00b7 can form biofilms<\/p>\n<p><b>5% xylitol significantly inhibits growth<\/b>; growth suppressed in pure culture (p &lt; 0.001).<\/p>\n<h3>Cutibacterium acnes<\/h3>\n<p>Common in sebum-rich areas \u00b7 overgrowth linked to breakouts<\/p>\n<p><b>5% xylitol significantly inhibits growth<\/b>; both tested strains suppressed (p &lt; 0.005\u20130.001).<\/p>\n<p>Mechanism: xylitol is difficult for opportunistic pathogens such as S. aureus to ferment, yet can be metabolized by specific resident flora; it also inhibits S. aureus glycocalyx synthesis and biofilm formation \u2014 the essential difference between prebiotic modulation and broad-spectrum antimicrobial action. Lactitol is likewise selectively utilized by beneficial bacteria in microbiome models.<\/p>\n<p>Sources: Anglenius et al., Korean J Microbiol, 2020 (in vitro, pure culture); Katsuyama et al., J Dermatol Sci, 2005; lactitol prebiotic evidence: Bj\u00f6rklund et al., Age, 2012 (microbiome model).<\/p>\n<p>06 \u00b7 REBUILDING THE NICHE<\/p>\n<h2>Beyond Inhibition \u2014 Rebuilding a Resident-Dominated Niche<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-ca9d1ee4d778f1e6ee6c3537d78d45af~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1790258379-0-0-4208a1202da17466263a6fdffe9fe9b8&amp;bizSceneCode=article_draft&amp;expiration=1790258379&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"592\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-ca9d1ee4d778f1e6ee6c3537d78d45af~resize:0:q75.png?source=1f5c5e47&amp;expiration=1790261457&amp;auth_key=1790261457-0-0-f5c846f367ed8ac8d0d4e008bea2b849&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-42299153f5aea3b95acdd805ecc621cb~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1790261458&amp;auth_key=1790261458-0-0-28d9124a4aeaf6e40a9461b109627f6e&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h3>Selectivity Is Clear<\/h3>\n<p>The combination inhibits biofilm formation by opportunistic S. aureus by up to 64.7%, while affecting resident S. epidermidis by only &lt; 2.5%.<\/p>\n<h3>Co-Culture Confirmation<\/h3>\n<p>The system reversed the growth advantage of S. aureus, restoring dominance to S. epidermidis \u2014 niche competition shifted back toward health.<\/p>\n<h3>In-Vivo Echo<\/h3>\n<p>A xylitol-containing cream applied to atopic dry skin significantly reduced S. aureus colonization and improved dryness within 4 weeks.<\/p>\n<p>Source: Katsuyama et al., J Dermatol Sci, 2005 (Part 2, human study).<\/p>\n<p>07 \u00b7 SKIN BARRIER<\/p>\n<h2>Microbiome \u2192 Barrier \u2192 Skin Resilience<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-4dedffbd74ad52323bc22a584896bddc~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1790258379-0-0-3c9568730eaf377599ac965de4e41cf4&amp;bizSceneCode=article_draft&amp;expiration=1790258379&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"468\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-4dedffbd74ad52323bc22a584896bddc~resize:0:q75.png?source=1f5c5e47&amp;expiration=1790261457&amp;auth_key=1790261457-0-0-429ed27d74e1e197b5c07eddeec39b42&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-956575a9f5da8532e32caa33da3a598a~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1790261457&amp;auth_key=1790261457-0-0-9be58cfe3d79bfacb23f397763332af3&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Human evidence: barrier support (14 days, n = 12, dry skin).<\/p>\n<table data-draft-node=\"block\" data-draft-type=\"table\" data-size=\"normal\" data-row-style=\"normal\">\n<tbody>\n<tr>\n<td>TEWL \u2193TEWL significantly reduced; barrier function improved<\/td>\n<td>Filaggrin \u2191More filaggrin-positive epidermal cells (~25% vs. control)<\/td>\n<td>Hydration \u2191Stratum corneum hydration and biomechanics improved together<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>A 5% glycerol + 5% xylitol formula used for 14 days: TEWL fell significantly while skin hydration, epidermal and dermal thickness, and the DEJ undulation index all rose; in-vitro data identify xylitol as the key component upregulating filaggrin expression.<\/p>\n<p>In an SLS acute-irritation human model, xylitol and glycerol showed dose-dependent anti-irritant and anti-inflammatory effects \u2014 direct evidence for sensitive-skin and compromised-barrier scenarios.<\/p>\n<p>Sources: Korponyai et al., Acta Derm Venereol, 2017 (in vivo); Sz\u00e9l et al., J Eur Acad Dermatol Venereol, 2015 (in vivo).<\/p>\n<p>08 \u00b7 HYDRATION<\/p>\n<h2>A Triple Hydration Mechanism: Film \u00b7 Humectancy \u00b7 NMF<\/h2>\n<p><b>8h<\/b>Biosaccharide Gum-1 hydration lasts 8 hours in human testingIngredient technical dossier (in-vivo volunteer study)<\/p>\n<h3>01 Film-Forming \u2014 a \u201cBreathable Moisture Film\u201d<\/h3>\n<p>The high-molecular-weight polysaccharide forms a non-occlusive moisturizing film on the skin surface, slowing water loss for immediate and long-lasting hydration with a silky, non-sticky feel.<\/p>\n<h3>02 Humectancy \u2014 Hydrogen-Bond \u201cWater Capture\u201d<\/h3>\n<p>The multi-hydroxyl structures of xylitol and lactitol bind water molecules through hydrogen bonds, raising stratum corneum water content and maintaining dynamic moisture balance even in dry environments.<\/p>\n<h3>03 Endogenous NMF \u2014 Upregulating Filaggrin<\/h3>\n<p>Xylitol upregulates filaggrin expression in keratinocytes \u2014 filaggrin breakdown products are the primary source of natural moisturizing factor (NMF), reinforcing hydration from within rather than relying on external humectants alone.<\/p>\n<p>Sources: Korponyai et al., Acta Derm Venereol, 2017; Cohen et al., J Chem Soc Faraday Trans, 1993; Biosaccharide Gum-1 ingredient technical dossier (in vivo).<\/p>\n<p>09 \u00b7 SOOTHING &amp; COMFORT<\/p>\n<h2>The Skin-Friendly Science of a Fucose-Rich Polysaccharide<\/h2>\n<p>Fucose is a natural component of human glycoproteins and glycolipids \u2014 skin \u201crecognizes\u201d Biosaccharide Gum-1, which is naturally highly affine and highly tolerated.<\/p>\n<p>This makes it a time-proven soothing ingredient for sensitive and reactive skin care.<\/p>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-84f5a8b101a355b908bbac679d74dfd0~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1790258379-0-0-af66a9a78c357f934669456c1dec40c8&amp;bizSceneCode=article_draft&amp;expiration=1790258379&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"541\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-84f5a8b101a355b908bbac679d74dfd0~resize:0:q75.png?source=1f5c5e47&amp;expiration=1790261457&amp;auth_key=1790261457-0-0-e5fc956e181ab2e50b77eff0bcd8b7c7&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-ceb5133ca359326bac87b4ee60e2afab~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1790261458&amp;auth_key=1790261458-0-0-cc6717e6c37d9bb61d5985561336d69b&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>Sources: Biosaccharide Gum-1 ingredient technical dossier (in-vivo volunteer testing); Sz\u00e9l et al., J Eur Acad Dermatol Venereol, 2015 (in vivo); CIR Expert Panel safety assessment of microbial polysaccharide gums.<\/p>\n<p>PART II \u00b7 THE SMART POWDER FORMAT<\/p>\n<h2>From Liquid Actives to a Smart Powder<\/h2>\n<p>A more stable, more convenient, more efficient delivery form for a microbiome active<\/p>\n<p>10 \u00b7 WHY POWDER<\/p>\n<h2>Why a Powder: Five Pain Points of Liquid Actives, Solved One by One<\/h2>\n<h3>Preservative-Free Format<\/h3>\n<p>Low water activity inhibits microbial growth, reducing reliance on preservatives.<\/p>\n<h3>Easy to Store<\/h3>\n<p>A solid form \u2014 simply sealed at room temperature; stable in long-term inventory.<\/p>\n<h3>Easy to Ship<\/h3>\n<p>Over 95% of water weight removed; built for global supply chains.<\/p>\n<h3>Easy to Handle<\/h3>\n<p>Free-flowing and non-caking; convenient to weigh and dose in both lab and production.<\/p>\n<h3>Easy to Disperse<\/h3>\n<p>Disperses quickly and evenly in the water phase; suitable for transparent formulas as well.<\/p>\n<table data-draft-node=\"block\" data-draft-type=\"table\" data-size=\"normal\" data-row-style=\"normal\">\n<tbody>\n<tr>\n<th>Traditional Liquid Actives<\/th>\n<th>BIOFUCO&#x2122; POWDER<\/th>\n<\/tr>\n<tr>\n<td>~97% water \u00b7 requires a preservation system<\/td>\n<td>Solid composite powder \u00b7 low water activity by design<\/td>\n<\/tr>\n<tr>\n<td>Heavy to ship \u00b7 shelf life challenged by microbes<\/td>\n<td>Light to ship \u00b7 storage-friendly \u00b7 flexible supply chain<\/td>\n<\/tr>\n<tr>\n<td>Low-dose actives are hard to weigh precisely<\/td>\n<td>Solid dilution ensures weighing and dispersion accuracy<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>The format comparison is based on the typical ~97% water content of liquid products in public technical literature; actual formulation performance should be verified.<\/p>\n<p>11 \u00b7 SMART SOLID DILUTION<\/p>\n<h2>Smart Solid Dilution: Every Milligram Under Precise Control<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-df0c2a23010376186e18ae91b4cc889c~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1790258379-0-0-0b4fc973cc9560aebfe176bb6a0600a1&amp;bizSceneCode=article_draft&amp;expiration=1790258379&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"438\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-df0c2a23010376186e18ae91b4cc889c~resize:0:q75.png?source=1f5c5e47&amp;expiration=1790261457&amp;auth_key=1790261457-0-0-937c3f0329a4cb9908cf293135c85995&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-f787079be40dd4c907fad4bb1043eb71~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1790261458&amp;auth_key=1790261458-0-0-eb788e1b608d28b19f87afe0db8dfcdb&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h3>What It Means for Formulators<\/h3>\n<ul>\n<li>Accurate dosing: gram-scale handling with milligram-level precision.<\/li>\n<li>Uniform dispersion: no local concentration spikes.<\/li>\n<li>Non-caking: free-flowing and disperses instantly in water.<\/li>\n<li>Scalable dosing: seamless scale-up from lab to production.<\/li>\n<li>Standardized delivery: consistent active content from batch to batch.<\/li>\n<li>High efficacy at low dose: a 1%\u20132% reference use level delivers the designed activity.<\/li>\n<\/ul>\n<p>Use levels are reference ranges and should be optimized against formulation goals; the solid dilution process is a product design description.<\/p>\n<p>12 \u00b7 SCALP MICROBIOME<\/p>\n<h2>The Scalp: An Ecosystem That Also Needs Balance<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-9018a14c09c9e9db29b4eec17c342cf2~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1790258379-0-0-91e384ca34828d1ce40b5b59baee766a&amp;bizSceneCode=article_draft&amp;expiration=1790258379&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"592\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-9018a14c09c9e9db29b4eec17c342cf2~resize:0:q75.png?source=1f5c5e47&amp;expiration=1790261457&amp;auth_key=1790261457-0-0-606558a1c72e57729566a8b65817b502&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-9b70b61372533e65e76f3385209fb323~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1790261458&amp;auth_key=1790261458-0-0-999bc880de861634827dfba591480b51&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<p>The microbial fingerprint of dandruff: lipophilic Malassezia rises from 46% to 74%\u201383%, while resident C. acnes falls from 26% to single digits \u2014 dandruff is fundamentally a flora-imbalance problem.<\/p>\n<p>The cascade of imbalance: dysbiosis accompanies elevated TEWL and pH plus a compromised scalp barrier, leading to dryness, itching, flaking, and scalp sensitivity.<\/p>\n<p>A new care target: maintain scalp flora homeostasis and nourish the resident ecology \u2014 the next generation of scalp care beyond \u201caggressive anti-dandruff.\u201d<\/p>\n<p>13 \u00b7 SCALP EVIDENCE<\/p>\n<h2>Xylitol \u00d7 Lactitol: Evidence for Scalp Hydration and Barrier<\/h2>\n<p><img src=\"https:\/\/pic-out.zhimg.com\/v2-5ae3602b7731863cab958972ba6d81cb~resize:1440:q75.png?animatedImageAutoPlay=false&amp;animatedImagePlayCount=1&amp;auth_key=1790258379-0-0-ab0734ada9e07e583df815836094ea7b&amp;bizSceneCode=article_draft&amp;expiration=1790258379&amp;incremental=false&amp;mid=af87d0ba5943ed43c9d129c257d04f1b&amp;overTime=60&amp;precoder=false&amp;protocol=v2&amp;retryCount=3&amp;sampling=false&amp;sceneCode=editor_copy_outbound&amp;source=bfcaadb1\" data-caption=\"\" data-size=\"normal\" data-rawwidth=\"1080\" data-rawheight=\"571\" data-watermark=\"original\" data-original-src=\"https:\/\/pic-private.zhihu.com\/v2-5ae3602b7731863cab958972ba6d81cb~resize:0:q75.png?source=1f5c5e47&amp;expiration=1790261457&amp;auth_key=1790261457-0-0-1cb8f7cacf50dd6cf879c8ce98e4191d&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-watermark-src=\"https:\/\/pic-private.zhihu.com\/v2-5a6640baca9a5bafda543a115a762134~resize:1440:q75.png?source=1f5c5e47&amp;expiration=1790261458&amp;auth_key=1790261458-0-0-510d990ccc010aced736dd537397280f&amp;protocol=v2&amp;sampling=False&amp;animatedImagePlayCount=1&amp;overTime=60&amp;incremental=False&amp;sceneCode=article_draft_web&amp;animatedImageAutoPlay=False&amp;retryCount=3&amp;precoder=False\" data-private-watermark-src=\"\" \/><\/p>\n<h3>Study Design<\/h3>\n<p>28 volunteers (16 women \/ 12 men) used a xylitol\u2013lactitol wash-and-care regimen 3 times over 10 days \u2014 shampoo 1% + conditioner 1% + leave-on product 2%, against a placebo control.<\/p>\n<h3>Results<\/h3>\n<p>Scalp hydration rose +27% immediately and held at +17% on day 10; TEWL improved by -12.7% (trend); video microscopy showed regulated desquamation and stronger scalp barrier integrity.<\/p>\n<h3>Implication<\/h3>\n<p>By restoring scalp ecological balance \u2014 feeding beneficial flora and restraining harmful flora \u2014 dryness, itching, and dandruff discomfort are relieved at the source.<\/p>\n<p>14 \u00b7 SKINCARE APPLICATIONS<\/p>\n<h2>Skincare Applications: From Concept to Everyday Formulas<\/h2>\n<h3>Microbiome Concepts<\/h3>\n<p>Microbiome skincare serums \u00b7 prebiotic \/ postbiotic creams \u00b7 post-cleansing microbiome care \u00b7 flora-balancing lotions<\/p>\n<h3>Targeted Care<\/h3>\n<p>Soothing care for sensitive skin \u00b7 barrier-repair creams \u00b7 long-lasting hydrating serums and masks \u00b7 microbiome care for blemish-prone skin<\/p>\n<h3>Gentle Scenarios<\/h3>\n<p>Gentle baby and child care \u00b7 hydrating soothing mists \u00b7 cleansers and rinse-off products \u00b7 after-sun repair gels<\/p>\n<p><b>Positioning: <\/b>a microbiome-friendly active \u00b7 a prebiotic skin-conditioning systemSuitable for leave-on and rinse-off systems; the water-soluble powder fits serums, creams, masks, mists, and cleansers.<\/p>\n<p>Whether for a new \u201cflora balance\u201d concept launch or a sensitive-skin formula that pairs soothing with barrier support, BioFuco&#x2122; Powder delivers a clear scientific narrative and formulator-friendliness through a concise INCI combination.<\/p>\n<p>15 \u00b7 HAIR &amp; SCALP CARE<\/p>\n<h2>From Scalp Ecology to Hair Condition<\/h2>\n<table data-draft-node=\"block\" data-draft-type=\"table\" data-size=\"normal\" data-row-style=\"normal\">\n<tbody>\n<tr>\n<td>Scalp MicrobiomeBalanced scalp flora<\/td>\n<td>Scalp BarrierScalp barrier integrity<\/td>\n<td>Comfort &amp; HydrationComfort and moisture<\/td>\n<td>Healthy HairA healthy environment for hair<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Typical Product Applications<\/h3>\n<ul>\n<li>Microbiome shampoos<\/li>\n<li>Leave-on scalp serums<\/li>\n<li>Soothing scalp mists<\/li>\n<li>Conditioners and hair masks<\/li>\n<li>Anti-dandruff support care<\/li>\n<li>Products for sensitive scalps<\/li>\n<\/ul>\n<p>Bonus: the film-forming property of Biosaccharide Gum-1 can remain on the hair fiber surface after rinsing, helping smooth the cuticle and enhance smoothness and shine (ingredient technical dossier).<\/p>\n<p>16 \u00b7 FORMULATOR-FRIENDLY<\/p>\n<h2>For Formulators: Usage Guide and Technical Notes<\/h2>\n<table data-draft-node=\"block\" data-draft-type=\"table\" data-size=\"normal\" data-row-style=\"normal\">\n<tbody>\n<tr>\n<th>Item<\/th>\n<th>Recommendation<\/th>\n<\/tr>\n<tr>\n<td>Reference use level<\/td>\n<td>0.5%\u20132.0% (reference range; optimize per formulation goals and efficacy positioning)<\/td>\n<\/tr>\n<tr>\n<td>Phase of addition<\/td>\n<td>Add to the water phase; \u226445\u00b0C for emulsion systems, room temperature for gels and aqueous systems<\/td>\n<\/tr>\n<tr>\n<td>Dissolution &amp; dispersion<\/td>\n<td>Sprinkle slowly into the water phase under stirring; disperses and dissolves within minutes; pre-disperse and sieve for transparent formulas<\/td>\n<\/tr>\n<tr>\n<td>pH suitability<\/td>\n<td>4.0\u20138.0 (reference range; suits mildly acidic to neutral systems)<\/td>\n<\/tr>\n<tr>\n<td>Compatibility &amp; compliance<\/td>\n<td>Good compatibility with common surfactants, thickeners, and preservation systems (reference); all three ingredients are IECIC-listed cosmetic raw materials; xylitol has been assessed by CIR<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>The above is a reference guide based on the ingredient&#8217;s public technical documentation and does not constitute precise process parameters; final formulation parameters should be confirmed through laboratory validation and stability testing.<\/p>\n<p>17 \u00b7 EVIDENCE CHAIN<\/p>\n<h2>The Evidence Chain: Mechanism \u2192 Evidence \u2192 Benefit<\/h2>\n<table data-draft-node=\"block\" data-draft-type=\"table\" data-size=\"normal\" data-row-style=\"normal\">\n<tbody>\n<tr>\n<th>Mechanism<\/th>\n<th>Key Evidence (Source \u00b7 Level)<\/th>\n<th>Cosmetic Benefit<\/th>\n<\/tr>\n<tr>\n<td>Selective microbiome modulation<\/td>\n<td>1% xylitol promotes S. epidermidis; 5% inhibits S. aureus \/ C. acnes \u2014 Anglenius et al., Korean J Microbiol, 2020 \u00b7 in vitro<\/td>\n<td>Microbiome-friendly concept<\/td>\n<\/tr>\n<tr>\n<td>Anti-biofilm &amp; niche rebuilding<\/td>\n<td>Xylitol inhibits S. aureus glycocalyx and biofilms \u2014 Katsuyama et al., J Dermatol Sci, 2005 \u00b7 in vitro + human; prebiotic blend inhibits S. aureus biofilms by up to 64.7% \u2014 Di Lodovico et al., Microorganisms, 2021 \u00b7 in vitro<\/td>\n<td>Blemish-prone and sensitive skin care<\/td>\n<\/tr>\n<tr>\n<td>Barrier strengthening<\/td>\n<td>Filaggrin expression up, TEWL significantly down (14 days, n=12) \u2014 Korponyai et al., Acta Derm Venereol, 2017 \u00b7 human<\/td>\n<td>Barrier repair<\/td>\n<\/tr>\n<tr>\n<td>Triple hydration<\/td>\n<td>Polysaccharide film hydrates for 8 hours \u2014 ingredient dossier \u00b7 human; polyol hydrogen bonding to water \u2014 Cohen et al., 1993; filaggrin\/NMF upregulation \u2014 Korponyai et al., 2017<\/td>\n<td>Long-lasting hydration<\/td>\n<\/tr>\n<tr>\n<td>Soothing &amp; comfort<\/td>\n<td>Post-challenge volunteer testing confirms soothing \u2014 ingredient dossier \u00b7 human; dose-dependent anti-irritation in the SLS model \u2014 Sz\u00e9l et al., JEADV, 2015 \u00b7 human<\/td>\n<td>Sensitive-skin comfort<\/td>\n<\/tr>\n<tr>\n<td>Scalp microbiome care<\/td>\n<td>Scalp hydration +27% (immediate) \/ +17% (day 10), TEWL -12.7% (day 10, n=28) \u2014 PCT\/IB2004\/004345 patent-family clinical data \u00b7 human<\/td>\n<td>Scalp and hair care<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>In-vitro \/ dossier data \u2260 finished-product clinical efficacy; third-party literature is for technical reference only and does not represent results for the BioFuco&#x2122; Powder finished formulation.<\/p>\n<p>SUMMARY &amp; CONTACT<\/p>\n<h2>Feed the beneficial flora. Balance the microbiome.<\/h2>\n<table data-draft-node=\"block\" data-draft-type=\"table\" data-size=\"normal\" data-row-style=\"normal\">\n<tbody>\n<tr>\n<td>Microbiome BalanceFeed residents, restrain opportunists<\/td>\n<td>Barrier SupportFilaggrin \u00b7 TEWL \u00b7 NMF<\/td>\n<td>HydrationFilm + humectancy + NMF<\/td>\n<\/tr>\n<tr>\n<td>Skin ComfortSoothing for sensitive skin<\/td>\n<td>Scalp CareBacked by clinical evidence<\/td>\n<td>Smart Powder FormatPreservative-free \u00b7 easy to use<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>PuriActives\u00ae BioFuco&#x2122; Powder \u2014 the prebiotic powder for skin and scalp microbiome balance<\/p>\n<p>PURIPHARM CO., LTD.<\/p>\n<p>www.puriactives.com \u00b7 service@puripharm.com \u00b7 +86-572-2745768Building 6, No. 1366 Hongfeng Road, Huzhou, Zhejiang, China<\/p>\n<p>This material is for cosmetic ingredient introduction only and does not constitute pharmaceutical claims; in-vitro and ingredient dossier data are not equivalent to finished-product clinical efficacy; cited third-party literature is for technical reference only. PuriActives\u00ae and BioFuco&#x2122; are trademarks of PURIPHARM CO., LTD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PuriActives\u00ae BioFuco&#x2122; Powder A Microbiome-Friend [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[40,71,34],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1406"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1406"}],"version-history":[{"count":1,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1406\/revisions"}],"predecessor-version":[{"id":1407,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/1406\/revisions\/1407"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1406"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}