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<\/p>\nDual-phase botanical smoothing \u00d7 retinoid-like renewal<\/p>\n
Smooth today. Renew tomorrow.<\/b><\/p>\n
Made with PURISOME\u00ae FlexVes™ liposome technology<\/p>\n
<\/p>\n
PuriPharm Co. Ltd. \u00b7 Innovation for health & beauty \u00b7 www.puriactives.com<\/p>\n
THE ANTI-AGING CHALLENGE \u00b7 \u6297\u8001\u6311\u6218<\/p>\n
Seconds \u2192 hoursThe apparent dimension of aging \u2014 seen and felt<\/b><\/p>\n
\u00b7 Facial-expression-related skin micro-relief<\/p>\n
\u00b7 Temporary appearance of expression lines<\/p>\n
\u00b7 Surface irregularity and roughness<\/p>\n
\u00b7 The wrinkles consumers notice first \u2014 and most want to improve quickly<\/p>\n
Weeks \u2192 monthsThe structural, biological dimension of aging<\/b><\/p>\n
\u00b7 Progressive loss of collagen and extracellular matrix<\/p>\n
\u00b7 Photoaging and cumulative oxidative stress<\/p>\n
\u00b7 Uneven pigmentation, slowed epidermal turnover<\/p>\n
\u00b7 Gradual loss of firmness and smoothness<\/p>\n
Effective anti-aging care must answer both clocks \u2014 immediately visible smoothing, and progressive biological renewal.<\/b><\/p>\n
THE CONCEPT \u00b7 \u4ea7\u54c1\u6982\u5ff5<\/p>\n
Acmella oleracea extract<\/b><\/p>\n
Fast-phase botanical smoothing, targeting the appearance of expression lines<\/p>\n
Bakuchiol<\/b><\/p>\n
Renewal phase \u2014 retinoid-like collagen and photoaging care<\/p>\n
PURISOME\u00ae<\/b><\/p>\n
Nano-liposome platform unifying protection, delivery, and release<\/p>\n
PhytoRetin Duo is designed to combine the two strategies \u2014 complementary, not redundant.<\/b><\/p>\n
PRODUCT AT A GLANCE \u00b7 \u4ea7\u54c1\u6982\u89c8<\/p>\n
| Item<\/th>\n | Details<\/th>\n<\/tr>\n | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| INCI names<\/td>\n | ACMELLA OLERACEA EXTRACT \/ BAKUCHIOL<\/td>\n<\/tr>\n | ||||||||||||||||||||||||||||
| Positioning<\/td>\n | Dual-phase botanical smoothing \u00d7 retinoid-like renewal<\/td>\n<\/tr>\n | ||||||||||||||||||||||||||||
| Technology platform<\/td>\n | PURISOME\u00ae FlexVes™ liposome technology \u2014 PuriPharm\u2019s proprietary nano-liposome platform<\/td>\n<\/tr>\n | ||||||||||||||||||||||||||||
| Core benefits<\/td>\n | Instantly visible smoothing \u00b7 expression-line appearance care \u00b7 collagen support \u00b7 photoaging care \u00b7 tone and texture improvement<\/td>\n<\/tr>\n | ||||||||||||||||||||||||||||
| Applications<\/td>\n | Facial serums \u00b7 eye care \u00b7 night repair \u00b7 sensitive-skin anti-aging \u00b7 scalp essences<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
A phospholipid bilayer vesicle encapsulating both botanical actives<\/p>\n Smooth today. Renew tomorrow.<\/b><\/p>\n EFFICACY ARCHITECTURE \u00b7 \u529f\u6548\u67b6\u6784<\/p>\n Why dual-phase anti-aging?<\/h2>\nMinutes \u2192 days<\/b><\/p>\n Instant \u2014 the apparent level<\/b><\/p>\n \u00b7 Rapidly and visibly smooths skin micro-relief<\/p>\n \u00b7 Expression-line appearance care<\/p>\n \u00b7 Surface refinement consumers can perceive quickly<\/p>\n Driven by Acmella oleracea extract<\/p>\n Weeks \u2192 months<\/b><\/p>\n Renewal \u2014 progressive biological renewal<\/b><\/p>\n \u00b7 Retinoid-like renewal and collagen support<\/p>\n \u00b7 Extracellular matrix protection and photoaging care<\/p>\n \u00b7 Gradual improvement in tone, texture, and firmness<\/p>\n Driven by bakuchiol<\/p>\n One ingredient answers today\u2019s mirror; the other invests in tomorrow\u2019s skin.<\/b><\/p>\n ACTIVE ONE \u00b7 FAST PHASE \u00b7 ACMELLA<\/p>\n Acmella oleracea \u2014 plant science and active chemistry<\/h2>\nA precision botanical for expression-line appearance.<\/b>Acmella oleracea (the \u201celectric daisy\u201d) is an Asteraceae plant whose aerial parts are rich in N-alkylamides \u2014 most notably spilanthol, which gives the extract its signature sensory and smoothing activity. In cosmetics, the extract is positioned for rapidly visible smoothing and refinement of skin micro-relief, especially in expression-active areas such as the eye contour.<\/p>\n Active chemistry<\/b><\/p>\n \u00b7 Spilanthol (N-isobutyl-2E,6Z,8E-decatrienamide) \u2014 the principal alkylamide in the flower heads<\/p>\n \u00b7 One of the bioactive N-isobutylamides isolated and identified from Spilanthes acmella (synonym of Acmella oleracea)<\/p>\n \u00b7 Lipophilic character \u2014 ideally suited to encapsulation in phospholipid vesicles<\/p>\n Cosmetic positioning:<\/b>rapidly visible smoothing \u00b7 expression-line appearance care \u00b7 refinement of skin micro-relief<\/p>\n Sources: Ramsewak RS, et al. Phytochemistry. 1999;51(6):729\u2013732. \u00b7 Savi\u0107 SM, et al. Int J Cosmet Sci. 2025;47(2):362\u2013382. doi:10.1111\/ics.13034<\/p>\n ACTIVE ONE \u00b7 MECHANISM \u00b7 \u673a\u5236<\/p>\n Rapid smoothing \u2014 the story of expression lines<\/h2>\nThe biology of expression lines<\/b><\/p>\n 1<\/b>\u3000Repeated facial movements create temporary mechanical folds in the skin surface<\/p>\n 2<\/b>\u3000The folds alter skin micro-relief \u2014 fine surface lines appear around the eyes and mouth<\/p>\n 3<\/b>\u3000With age and slowing turnover, the temporary creases become increasingly persistent and visible<\/p>\n Ex vivo evidence<\/b><\/p>\n In an ex vivo nerve\u2013muscle co-culture model, Acmella oleracea extract produced a rapid, dose-dependent, and fully reversible<\/b> inhibition of muscle-fiber contraction frequency.<\/p>\n Contractile activity recovered within one hour of washout \u2014 supporting a gentle, non-destructive cosmetic mode of action.<\/p>\n This evidence supports cosmetic smoothing claims only \u2014 no pharmacological or neuromuscular claims are made.<\/p>\n Acmella extract delivers rapidly perceptible smoothing of expression-line appearance \u2014 the \u201cfast\u201d half of the dual-phase strategy.<\/b><\/p>\n Source: Demarne F, Passaro G. Use of an Acmella oleracea extract in an anti-wrinkle cosmetic composition. US Patent 7,531,193 B2. 2009.<\/p>\n ACTIVE ONE \u00b7 CLINICAL EVIDENCE \u00b7 \u4e34\u5e8a\u8bc1\u636e<\/p>\n Acmella \u2014 measurable smoothing on human skin<\/h2>\nStudy design<\/b><\/p>\n \u00b7 Test system: human volunteers, eye-contour and perioral areas<\/p>\n \u00b7 Design: randomized, split-face, controlled reference<\/p>\n \u00b7 Test product: serum containing Acmella oleracea extract<\/p>\n \u00b7 Duration: 2 weeks, twice daily<\/p>\n \u00b7 Endpoints: hydration, smoothness, roughness, desquamation, wrinkle parameters<\/p>\n +10\u201340%<\/b>Skin hydration (p < 0.05)<\/p>\n ~+15%<\/b>Skin smoothness (p < 0.05)<\/p>\n \u221220\u201330%<\/b>Skin roughness (p < 0.05)<\/p>\n ~\u221215%<\/b>Wrinkle parameters (p < 0.05)<\/p>\n Tolerability:<\/b>no eye-irritation potential (HET-CAM test), and spilanthol did not permeate porcine-ear skin \u2014 supporting a favorable topical safety profile.<\/p>\n Source: Savi\u0107 SM, et al. Int J Cosmet Sci. 2025;47(2):362\u2013382. doi:10.1111\/ics.13034 \u00b7 Ingredient-level evidence (Grade B) \u2014 not finished-product data on PhytoRetin Duo.<\/p>\n ACTIVE TWO \u00b7 RENEWAL PHASE \u00b7 BAKUCHIOL<\/p>\n Bakuchiol \u2014 the modern botanical retinol alternative<\/h2>\nA phenolic monoterpene isolated from the seeds of Psoralea corylifolia. Structurally unrelated to retinoids, bakuchiol is a functional analog<\/b> of retinol \u2014 acting on overlapping renewal pathways without retinol\u2019s signature irritation.<\/p>\n \u00b7 Retinoid-like gene-expression signature, with an entirely different molecular structure<\/p>\n \u00b7 Photostable \u2014 suitable for morning and evening use<\/p>\n \u00b7 Antioxidant activity supporting photoaging care<\/p>\n \u00b7 Clinically demonstrated better tolerability than retinol<\/p>\n Molecular profile<\/b><\/p>\n Bakuchiol \u00b7 phenolic monoterpene (meroterpene)<\/p>\n C\u2081\u2088H\u2082\u2084O \u00b7 molecular weight 256.4<\/p>\n Lipophilic \u2014 ideally suited to lipid-bilayer encapsulation<\/p>\n \u201cRetinoid-like\u201d describes functional similarity \u2014 not retinoic-acid-receptor agonism.<\/p>\n Sources: Chaudhuri RK, Bojanowski K. Int J Cosmet Sci. 2014;36(3):221\u2013230. \u00b7 Dhaliwal S, et al. Br J Dermatol. 2019;180(2):289\u2013296.<\/p>\n ACTIVE TWO \u00b7 MECHANISM \u00b7 \u673a\u5236<\/p>\n Bakuchiol \u2014 renewal across four dimensions<\/h2>\nCollagen support<\/b> \u2014 gene-expression studies show up-regulation of collagen types I and IV, and stimulation of type III collagen in mature fibroblasts.<\/p>\n Extracellular matrix protection<\/b> \u2014 supports the dermal matrix environment that underlies firmness and visible wrinkle depth.<\/p>\n Antioxidant defense<\/b> \u2014 proven antioxidant activity against oxidative stress, the central driver of photoaging.<\/p>\n Tone & pigmentation care<\/b> \u2014 clinically observed improvement in the appearance of pigmentation, complementing the anti-wrinkle benefit.<\/p>\n A multi-pathway botanical acting on the structural timeline of skin aging \u2014 measured in weeks and months, not minutes.<\/b><\/p>\n Sources: Chaudhuri RK, Bojanowski K. Int J Cosmet Sci. 2014;36(3):221\u2013230. \u00b7 Dhaliwal S, et al. Br J Dermatol. 2019;180(2):289\u2013296.<\/p>\n ACTIVE TWO \u00b7 MOLECULAR EVIDENCE \u00b7 \u5206\u5b50\u8bc1\u636e<\/p>\n A retinoid-like molecular signature<\/h2>\nGene-expression profiling \u2014 CHAUDHURI & BOJANOWSKI (2014)<\/b><\/p>\n DNA microarray analysis on skin models showed a broad overall similarity<\/b> between the gene-expression effects of bakuchiol and retinol \u2014 despite no structural resemblance between the two molecules. The similarity was confirmed gene by gene and validated at the protein level by ELISA and histochemistry. Key renewal markers \u2014 collagens I, III, IV and aquaporin 3 \u2014 were all modulated in a retinoid-like direction.<\/p>\n \u00b7 Microarray<\/b> \u2014 retinoid-like modulation of the skin gene-expression profile<\/p>\n \u00b7 Protein level<\/b> \u2014 collagen stimulation confirmed by ELISA and histochemistry<\/p>\n \u00b7 Clinical case<\/b> \u2014 twice-daily use for 12 weeks improved fine lines, wrinkles, pigmentation, elasticity, and firmness<\/p>\n Functional similarity \u2014 without retinol-associated adverse effects in this study.<\/b><\/p>\n Claim boundary: bakuchiol is described as retinoid-like \/ retinol-inspired \u2014 not as a retinoic-acid-receptor agonist.<\/p>\n Source: Chaudhuri RK, Bojanowski K. Int J Cosmet Sci. 2014;36(3):221\u2013230. doi:10.1111\/ics.12117<\/p>\n ACTIVE TWO \u00b7 CLINICAL EVIDENCE \u00b7 \u4e34\u5e8a\u8bc1\u636e<\/p>\n Head-to-head against retinol \u2014 Dhaliwal et al., 2019<\/h2>\nStudy design<\/b><\/p>\n \u00b7 Design: prospective, randomized, double-blind<\/p>\n \u00b7 Subjects: 44 (facial photoaging)<\/p>\n \u00b7 Regimen: bakuchiol 0.5% cream twice daily vs retinol 0.5% cream once daily<\/p>\n \u00b7 Duration: 12 weeks, assessed at weeks 0\/4\/8\/12<\/p>\n \u00b7 Endpoints: wrinkle surface area (image analysis), physician-graded pigmentation, tolerability<\/p>\n
The two compounds showed no statistically significant difference on wrinkle and pigmentation endpoints. Photoaging improvement was comparable \u2014 while the bakuchiol group reported significantly less facial scaling and stinging.<\/b><\/p>\n Source: Dhaliwal S, et al. Br J Dermatol. 2019;180(2):289\u2013296. doi:10.1111\/bjd.16918 \u00b7 Ingredient-level evidence (Grade B).<\/p>\n THE DUO SYSTEM \u00b7 \u53cc\u6d3b\u6027\u4f53\u7cfb<\/p>\n Two timelines, one active system<\/h2>\nFast phase \u00b7 Acmella oleracea extract<\/b><\/p>\n Rapidly visible smoothing \u00b7 expression-line appearance care \u00b7 surface and micro-relief refinement<\/p>\n +<\/b><\/p>\n Renewal phase \u00b7 Bakuchiol<\/b><\/p>\n Collagen support \u00b7 extracellular matrix protection and photoaging care \u00b7 tone and texture improvement<\/p>\n PhytoRetin Duo \u2014 instant + progressive beauty performance<\/b><\/p>\n A two-phase strategy built on complementary botanical mechanisms \u2014 ingredient-level evidence; no combination-synergy claim is made.<\/p>\n DELIVERY PLATFORM \u00b7 \u9012\u9001\u5e73\u53f0<\/p>\n PURISOME\u00ae FlexVes™ liposome technology<\/h2>\nPURISOME\u00ae is PuriPharm\u2019s proprietary advanced nano-liposome platform, built on more than a decade of nano-delivery R&D and industrialization experience. Both botanical actives are encapsulated within skin-affine phospholipid bilayer vesicles.<\/p>\n 01\u3000Encapsulation & protection<\/b> \u2014 protects oxidation- and degradation-prone actives, extending shelf-life stability.<\/p>\n 02\u3000Enhanced penetration<\/b> \u2014 promotes interaction with the stratum corneum, deposition, and bioavailability.<\/p>\n 03\u3000Sustained release<\/b> \u2014 gradual, controlled release extends contact time with a gentler skin feel.<\/p>\n 04\u3000Formulation elegance<\/b> \u2014 improves formulation compatibility and sensory performance.<\/p>\n
Phospholipid bilayer vesicle \u2014 the PURISOME\u00ae carrier structure<\/p>\n PURISOME\u00ae SCIENCE \u00b7 \u79d1\u5b66<\/p>\n Why nano-scale lipid delivery?<\/h2>\n
Fluorescence skin cross-sections \u2014 the smaller the lipid vesicle, the deeper it reaches into the skin (particle size decreases a \u2192 c). Redrawn from Verma DD, et al. Int J Pharm. 2003;258:141\u2013151.<\/p>\n Particle size determines deposition.<\/b>Reducing vesicle size increases the total contact area with skin, supporting more efficient delivery into its superficial structures.<\/p>\n
Nano-scale carriers distribute between superficial corneocytes and deposit in the skin\u2019s shallow structures.<\/p>\n Large particles stay on the surface; nano-scale vesicles spread, conform, and deposit where they can make a difference.<\/p>\n PURISOME\u00ae engineers carriers to the nano scale \u2014 because particle size decides how far an active can go.<\/b><\/p>\n Source: Verma DD, Verma S, Blume G, Fahr A. Int J Pharm. 2003;258(1\u20132):141\u2013151. \u00b7 Delivery-platform literature (Grade C) \u2014 the scientific basis of the PURISOME\u00ae approach.<\/p>\n PURISOME\u00ae SCIENCE \u00b7 \u79d1\u5b66<\/p>\n Skin-affine phospholipid delivery<\/h2>\nBarrier interaction<\/b> \u2014 phospholipid vesicles are structurally compatible with the skin\u2019s own lipid environment, adsorbing to and interacting with the stratum-corneum lipid matrix.<\/p>\n Sustained delivery<\/b> \u2014 encapsulated actives release progressively at the skin surface and in shallow structures \u2014 extending contact time and smoothing transient concentration peaks.<\/p>\n Moisture-support film<\/b> \u2014 a continuous nano-scale lipid film supports the barrier\u2019s water-retention function.<\/p>\n
The smaller the particles, the more continuous the surface film formed by lipid nanoparticles \u2014 effective surface coverage and contact increase accordingly.<\/p>\n A carrier built in the skin\u2019s own chemical language \u2014 welcomed, not resisted.<\/b><\/p>\n Sources: Cevc G, Blume G. Biochim Biophys Acta. 1992;1104:226\u2013232. \u00b7 Honeywell-Nguyen PL, et al. Adv Drug Deliv Rev. 2004;56(5):603\u2013631. \u00b7 Delivery-platform literature (Grade C).<\/p>\n PURISOME\u00ae SCIENCE \u00b7 \u79d1\u5b66<\/p>\n The follicular reservoir and targeted delivery<\/h2>\n
Follicular deposition concept \u2014 surface (a), infundibulum (b), and deep-follicle (c) delivery zones. SC: stratum corneum \u00b7 E: epidermis \u00b7 D: dermis. Redrawn from Patzelt & Lademann.<\/p>\n
The hair follicle as a reservoir and shunt pathway for lipid carriers of suitable particle size.<\/p>\n A size-selective pathway<\/b> \u2014 nanoparticles can enter open hair follicles; in porcine-skin models, nm-scale particles reached the deepest follicular regions, driven by a \u201cgear-pump\u201d effect of hair movement.<\/p>\n A built-in reservoir<\/b> \u2014 particles deposited in follicles can be stored for days, supporting prolonged local release of encapsulated actives.<\/p>\n Scalp relevance<\/b> \u2014 high follicular density makes the scalp a natural target for follicular delivery \u2014 a technical rationale for premium scalp essences.<\/p>\n Sources: Patzelt A, et al. Eur J Pharm Biopharm. 2011;77(3):427\u2013436. \u00b7 Lademann J, et al. Skin Pharmacol Physiol. 2007;20(5):232\u2013238. \u00b7 Vogt A, et al. J Invest Dermatol. 2006;126(6):1316\u20131322. \u00b7 Delivery-platform literature (Grade C).<\/p>\n COMMERCIAL OPPORTUNITY \u00b7 SKINCARE APPLICATIONS<\/p>\n Skincare applications<\/h2>\n\u00b7 Anti-aging serums<\/b> \u2014 the flagship format of the dual-phase positioning<\/p>\n \u00b7 Eye care<\/b> \u2014 crow\u2019s-feet smoothing + progressive renewal<\/p>\n \u00b7 Expression-line serums<\/b> \u2014 precision care for high-movement areas<\/p>\n \u00b7 Premium night serums<\/b> \u2014 the overnight renewal narrative<\/p>\n \u00b7 Retinol-alternative products<\/b> \u2014 botanical renewal without retinol irritation<\/p>\n \u00b7 Sensitive-skin anti-aging<\/b> \u2014 a gentle renewal positioning<\/p>\n \u00b7 Brightening + anti-aging<\/b> \u2014 pigmentation care combined with anti-wrinkle care<\/p>\n \u00b7 Neck & d\u00e9collet\u00e9 care<\/b> \u2014 smoothing care for delicate expression zones<\/p>\n One active system \u2014 an entire premium anti-aging product line.<\/b><\/p>\n COMMERCIAL OPPORTUNITY \u00b7 SCALP & HAIR<\/p>\n Scalp & hair care opportunities<\/h2>\nPositioning within strict evidence boundaries<\/b><\/p>\n \u00b7 Scalp renewal<\/b> \u2014 bakuchiol\u2019s retinoid-like renewal logic extends naturally to scalp skin<\/p>\n \u00b7 Antioxidant scalp care<\/b> \u2014 defending the follicular microenvironment against oxidative stress<\/p>\n \u00b7 Healthy scalp environment<\/b> \u2014 conditioning and barrier support<\/p>\n \u00b7 Scalp anti-aging concept<\/b> \u2014 the scalp ages like facial skin, yet rarely receives the same care<\/p>\n \u00b7 Premium scalp-essence positioning<\/b> \u2014 a differentiated, science-driven story<\/p>\n The PURISOME\u00ae scalp advantage<\/b><\/p>\n The scalp carries the highest density of terminal hair follicles in the human body.<\/p>\n PURISOME\u00ae nano-lipid carriers are sized within the range indicated by follicular-delivery literature, depositing in the follicular reservoir \u2014 enabling prolonged, localized release at the follicle.<\/p>\n Evidence discipline: the scalp positioning is built on ingredient-level skin evidence and delivery-platform rationale. No direct human hair-growth claim is made for either active.<\/p>\n Sources: Patzelt A, et al. Eur J Pharm Biopharm. 2011;77(3):427\u2013436. \u00b7 Lademann J, et al. Skin Pharmacol Physiol. 2007;20(5):232\u2013238.<\/p>\n FOR FORMULATORS \u00b7 \u81f4\u914d\u65b9\u5e08<\/p>\n Formulation opportunities<\/h2>\nPURISOME\u00ae encapsulation is designed for formulation compatibility and sensory elegance, allowing PhytoRetin Duo to fit a broad range of leave-on formats.<\/p>\n
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