PURIPHARM CO. LTD. \u00b7 SCIENTIFIC PRODUCT PRESENTATION \u00b7 TECHNICAL MARKETING MATERIAL<\/p>\n
Polyamino Sugar Condensate<\/p>\n
NMF-Inspired Hydration Conditioning \u00b7 For Skin and Hair<\/b><\/p>\n![](\"https:\/\/pic-out.zhimg.com\/v2-f6164c0715dc7207addebb66e6f7fe9a~resize:1440:q75.jpg?animatedImageAutoPlay=false&animatedImagePlayCount=1&auth_key=1790834791-0-0-e84168b845846976a2e31e57b003dfac&bizSceneCode=article_draft&expiration=1790834791&incremental=false&mid=af87d0ba5943ed43c9d129c257d04f1b&overTime=60&precoder=false&protocol=v2&retryCount=3&sampling=false&sceneCode=editor_copy_outbound&source=bfcaadb1\")
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INCI NAME<\/b>\u3000POLYAMINO SUGAR CONDENSATE<\/p>\n
CAS NUMBER<\/b>\u3000120022-92-6<\/p>\n
AUDIENCE<\/b>\u3000Cosmetic R&D \u00b7 Formulation \u00b7 Technical Marketing<\/p>\n
THE HYDRATION CHALLENGE<\/p>\n
Why water management matters equally for skin and hair<\/p>\n
Skin<\/b><\/p>\n
A water-gradient tissue.<\/b> The stratum corneum is driest at the surface, with water content rising toward the viable epidermis; its mechanical softness depends precisely on that water.<\/p>\n
Water is lost continuously.<\/b> Low humidity, seasonal change, and frequent cleansing all make the stratum corneum lose water faster than it can be replenished.<\/p>\n
Skin feel tracks hydration.<\/b> As water content falls, corneocytes lose plasticity \u2014 skin feels tight, rough, and no longer supple.<\/p>\n
Hair and Scalp<\/b><\/p>\n
A non-living keratin fiber.<\/b> Hair cannot repair itself; its softness, flexibility, and manageability are governed by water status and surface condition.<\/p>\n
Damage accumulates.<\/b> Chemical treatments, heat styling, and UV lift the cuticle, increase inter-fiber friction, and alter moisture-uptake behavior.<\/p>\n
The scalp is skin too.<\/b> The same stratum-corneum hydration logic applies where the hair is rooted.<\/p>\n
Behind skin feel and hair feel lies one shared variable: the hydration state of keratin.<\/b><\/p>\n
PRODUCT OVERVIEW<\/p>\n
Sugar-derived + amino-acid-derived humectant chemistry in one ingredient system<\/p>\n
PuriActives\u00ae PuriNMF is a condensed cosmetic ingredient system that unites sugar-derived hydrophilic functionality with amino-acid-derived functionality \u2014 designed for water management and conditioning of skin, scalp, and hair.<\/p>\n
| INCI<\/td>\n | POLYAMINO SUGAR CONDENSATE<\/td>\n<\/tr>\n | |||||||||||||||||||||||||||||||||||||||||||
| CAS No.<\/td>\n | 120022-92-6<\/td>\n<\/tr>\n | |||||||||||||||||||||||||||||||||||||||||||
| Positioning<\/td>\n | NMF-inspired hydration conditioning<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n Core Benefit Pillars<\/b><\/p>\n 01<\/b>\u3000Attracts water<\/p>\n 02<\/b>\u3000Retains water<\/p>\n 03<\/b>\u3000Keratin conditioning<\/p>\n 04<\/b>\u3000Skin softness & suppleness<\/p>\n 05<\/b>\u3000Hair softness & manageability<\/p>\n 06<\/b>\u3000Scalp hydration<\/p>\n 07<\/b>\u3000For rinse-off and leave-on systems<\/p>\n Positioning statement: PuriNMF is designed in line with the biological logic of the natural moisturizing factor (NMF); its chemical composition is not identical to endogenous NMF.<\/p>\n THE INGREDIENT<\/p>\n What Is Polyamino Sugar Condensate?<\/h2>\nIngredient identity, cosmetic function, and ingredient heritage<\/p>\n Ingredient identity<\/b> \u2014 a condensate of sugar-derived and amino-acid-derived structural units, supplied as a single cosmetic ingredient under a single INCI name.<\/p>\n Cosmetic function<\/b> \u2014 humectant and skin-conditioning chemistry: a dense array of polar functional groups provides multiple water-association sites at the keratin interface.<\/p>\n Heritage and safety precedent<\/b> \u2014 a well-established cosmetic ingredient with a long history of use. Its safety was assessed in a published JACT report (1982) and reviewed again in 2023 by the Cosmetic Ingredient Review (CIR) Expert Panel.<\/p>\n Final Report of the Safety Assessment of Polyamino Sugar Condensate. J Am Coll Toxicol. 1982;1(4):25\u201332. \u00b7 Raj PS, et al. Int J Toxicol. 2023;42(3 Suppl):91S\u201392S.<\/p>\n NMF SCIENCE<\/p>\n Filaggrin proteolysis generates amino-acid chemistry that locks water into the stratum corneum<\/p>\n Filaggrin \u2192 proteolysis in the upper epidermis \u2192 release of free amino acids \u2192 formation of NMF components such as PCA \u2192 water binding within corneocytes \u2192 corneocyte plasticity maintained \u2192 supple, smooth skin<\/b><\/p>\n Layered structure of the epidermis. Illustration: OpenStax, Anatomy & Physiology, Wikimedia Commons, CC BY 4.0.<\/p>\n Positioning note: PuriNMF is an NMF-inspired design \u2014 built around amino-acid and sugar humectant chemistry; its composition is not identical to endogenous NMF.<\/p>\n What NMF does:<\/b> stratum corneum hydration \u00b7 water retention \u00b7 keratin flexibility \u00b7 corneocyte mechanics \u00b7 surface smoothness<\/p>\n NMF SCIENCE<\/p>\n NMF composition and its role in keratin hydration<\/p>\n Approximate shares of NMF dry weight. Source: Rawlings AV, Harding CR. Dermatol Ther. 2004;17(Suppl 1):43\u201348.<\/p>\n Amino-acid-derived solutes bind water inside corneocytes and keep keratin flexible \u2014 the biochemical foundation of a soft, smooth skin surface.<\/p>\n Raman depth profiling: NMF concentrates in the upper stratum corneum. Semi-quantitative NMF concentration versus stratum-corneum depth, placebo (A) versus an NMF-containing formulation (B). Figure: Schleusener J, et al. Molecules. 2021;26(6):1649. DOI: 10.3390\/molecules26061649.<\/p>\n Why it matters:<\/b> the NMF-rich upper stratum corneum is exactly where dryness is felt first. Hydration strategies acting at this interface address the sensory core of dry skin.<\/p>\n NMF SCIENCE<\/p>\n Hydroxyl-rich systems interact with water through dense hydrogen-bonding functionality<\/p>\n Hydroxyl-rich water interaction<\/b> \u2014 sugar-derived units carry dense hydroxyl (\u2013OH) groups. Each \u2013OH can form hydrogen bonds with water molecules, associating water at the keratin interface.<\/p>\n Hygroscopic buffering<\/b> \u2014 sugar-derived systems slow evaporation by lowering surface water activity, helping the stratum corneum hold onto water in dry environments.<\/p>\n Evidence Note \u2014 Drying Model<\/b><\/p>\n An in vitro Raman desorption study showed that a natural sugar-derived complex \u2014 most pronounced in combination with glycerol \u2014 increased total, partially bound, and unbound water at the skin surface and at 8 \u00b5m stratum-corneum depth over a 6-hour drying period.<\/p>\n Sugar-derived systems can prolong water retention during drying.<\/b><\/p>\n Fluhr JW, et al. J Biophotonics. 2023;16:e202200201. DOI: 10.1002\/jbio.202200201. Ingredient-class evidence, not PuriNMF product data.<\/p>\n MECHANISTIC MODEL<\/p>\n A two-dimensional functional model \u2014 from condensate chemistry to conditioned keratin<\/p>\n A functional mechanistic model based on ingredient-class scientific principles \u2014 not a chemical structure, and not product-specific efficacy data.<\/p>\n WATER-BINDING SCIENCE<\/p>\n Distinct water states together define stratum-corneum hydration<\/p>\n Tightly bound water<\/b> \u2014 closely associated with the polar sites of keratin and NMF \u2014 the structural water that maintains corneocyte plasticity.<\/p>\n Partially bound water<\/b> \u2014 weakly associated, exchangeable water \u2014 a buffering pool that responds to the environment and the formulation.<\/p>\n Mobile \/ unbound water<\/b> \u2014 freely moving water \u2014 the first fraction to evaporate, and the hardest to keep without humectant support.<\/p>\n Measurement is key.<\/b> Confocal Raman microspectroscopy can resolve these water states along stratum-corneum depth \u2014 making hydration measurable below the surface.<\/p>\n In vivo confocal Raman spectra of human stratum corneum \u2014 fingerprint region (A) and high-wavenumber region (B). The 3,000\u20133,700 cm\u207b\u00b9 water band is the analytical basis for resolving water states.<\/p>\n Formulation implication:<\/b> ingredients that raise the bound-water fraction \u2014 not just total water \u2014 support a hydration state that persists between applications.<\/p>\n Figures: Schleusener J, et al. Molecules. 2021;26(6):1649. \u00b7 Fluhr JW, et al. J Biophotonics. 2023;16:e202200201.<\/p>\n EVIDENCE FOCUS<\/p>\n In vivo Raman depth profiling of formulations containing NMF components<\/p>\n Relative tightly bound water content versus stratum-corneum depth after placebo (C) and an NMF-component formulation (D), over 14 days of follow-up. Black: untreated control. Figure (panels C\u2013D): Schleusener J, et al. Molecules. 2021;26(6):1649. DOI: 10.3390\/molecules26061649. Ingredient-class evidence, not PuriNMF product data.<\/p>\n After twice-daily use of a formulation containing NMF components, tightly bound water increased in the superficial stratum corneum \u2014 the zone where dryness is first perceived.<\/p>\n A complementary Raman desorption study points the same way for sugar-derived systems: higher total, partially bound, and unbound water under drying stress.<\/p>\n Key point:<\/b> NMF and sugar humectant chemistry acts on bound water \u2014 below the surface, not merely at it.<\/p>\n Fluhr JW, et al. J Biophotonics. 2023;16:e202200201.<\/p>\n FROM WATER TO TOUCH<\/p>\n The mechanical meaning of a hydrated stratum corneum<\/p>\n 01<\/b>\u3000Water associates with the polar sites of keratin and NMF components.<\/p>\n 02<\/b>\u3000Corneocytes swell with water, stay plastic, and resist brittle fracture on bending.<\/p>\n 03<\/b>\u3000The stratum corneum softens \u2014 surface roughness and the feeling of tightness recede.<\/p>\n 04<\/b>\u3000Skin feels soft and smooth \u2014 the sensory endpoint of hydration.<\/p>\n Lateral (A\u2013B) and lamellar (C\u2013D) organization of intercellular lipids along stratum-corneum depth \u2014 Raman-based structural parameters. Figure: Schleusener J, et al. Molecules. 2021;26(6):1649. DOI: 10.3390\/molecules26061649.<\/p>\n Barrier context:<\/b> ordered lateral packing of intercellular lipids locks water in place \u2014 hydration and lipid organization work as one system.<\/p>\n SKINCARE POSITIONING<\/p>\n Hydration \u00b7 Softness \u00b7 Conditioning \u2014 a structured skin-benefit platform<\/p>\n A\u3000HYDRATION<\/b>Supports water attraction and retention at the stratum-corneum interface.<\/p>\n B\u3000SOFTNESS<\/b>Maintains a softer, more supple stratum-corneum feel.<\/p>\n C\u3000CONDITIONING<\/b>Provides a hydrated surface environment compatible with care concepts for dry, stressed skin.<\/p>\n D\u3000POST-CLEANSING COMFORT<\/b>Suited to cleansing systems where tightness and dryness are formulation challenges.<\/p>\n E\u3000NMF-INSPIRED CARE<\/b>A strong science-marketing bridge to endogenous moisturizing biology.<\/p>\n F\u3000DRY-SKIN APPLICATIONS<\/b>For dry skin, seasonal dryness, low-humidity environments, frequent cleansing, mature skin, body care, hand care, and barrier-oriented formulations.<\/p>\n One ingredient platform across leave-on skincare and rinse-off cleansing systems.<\/b><\/p>\n SKIN \u2014 PUBLISHED PRECEDENT<\/p>\n Published patent literature on Polyamino Sugar Condensate in topical cleansing\/conditioning compositions<\/p>\n EP 0 535 789 A2<\/b><\/p>\n Topical cleansing and conditioning compositions<\/p>\n This published application discloses topical cleansing and conditioning compositions containing Polyamino Sugar Condensate, covering its use in skin-cleansing systems with a conditioning benefit. It establishes a direct documentary link between this ingredient and rinse-off skin-conditioning concepts.<\/p>\n What it supports<\/b><\/p>\n \u00b7 Cosmetic humectant use of the ingredient\u3000\u00b7 Skin-conditioning positioning<\/p>\n \u00b7 Relevance in cleansing formulations\u3000\u00b7 Suitability for rinse-off products<\/p>\n What it is not<\/b><\/p>\n \u00b7 Not clinical evidence for PuriNMF\u3000\u00b7 Not an efficacy study of a PuriPharm finished product<\/p>\n EP0535789A2. Cited as a published formulation precedent; the patentee is deliberately omitted. Patent disclosure \u2260 clinical proof.<\/p>\n HAIR SCIENCE<\/p>\n Fiber structure, surface condition, and how damage shows up<\/p>\n SEM of a human hair fiber: overlapping cuticle scales (\u00d71.0k, scale bar 50 \u00b5m). Image: CSIRO ScienceImage 8115, CC BY 3.0.<\/p>\n Hair damage can appear as<\/b><\/p>\n Lifted cuticle \u00b7 increased surface roughness \u00b7 higher friction \u00b7 altered moisture-uptake behavior \u00b7 brittleness \u00b7 loss of flexibility \u00b7 poor manageability<\/p>\n Hair-fiber cross-section (schematic):<\/b> cuticle (protective scales) \u00b7 cortex (keratin-rich matrix) \u00b7 medulla (when present)<\/p>\n Intercellular regions hold the structure together.<\/p>\n What determines fiber feel is surface condition and moisture behavior \u2014 not color or styling.<\/b><\/p>\n HAIRCARE POSITIONING<\/p>\n Hydration \u00b7 Softness \u00b7 Flexibility \u00b7 Manageability<\/p>\n Water association<\/b> \u2014 supports hydration at the hair-surface interface.<\/p>\n Soft touch<\/b> \u2014 helps maintain a soft feel along the fiber.<\/p>\n Flexibility<\/b> \u2014 a hydrated keratin environment helps improve fiber flexibility.<\/p>\n Manageability<\/b> \u2014 suited to formulations targeting dry, stressed, or chemically treated hair.<\/p>\n Scalp hydration<\/b> \u2014 extends NMF-inspired hydration thinking to scalp care.<\/p>\n Target Formats<\/b><\/p>\n Shampoos \u00b7 conditioners \u00b7 hair masks \u00b7 leave-in conditioners \u00b7 moisturizing mists \u00b7 hair serums \u00b7 scalp serums \u00b7 scalp sprays \u00b7 scalp masks \u00b7 pre-wash treatments \u00b7 dry-hair care \u00b7 curly-hair care \u00b7 chemically treated hair care<\/p>\n Cuticle detail, SEM (scale bar 20 \u00b5m). Image: Foreade, Wikimedia Commons, CC BY-SA 4.0.<\/p>\n Claim discipline:<\/b> PuriNMF makes no bond-repair or disulfide-bond-repair claims.<\/p>\n SCALP + HAIR \u00b7 SIGNATURE<\/p>\n HAIR & SCALP \u2014 PUBLISHED PRECEDENT<\/p>\n Polyamino Sugar Condensate in documented hair and scalp care compositions<\/p>\n US 5,523,078 A<\/b><\/p>\n Hair and scalp care compositions and methods of making<\/p>\n This granted patent applies Polyamino Sugar Condensate in hair and scalp care compositions, disclosing use levels of 0.1\u20130.25 wt%. It documents an established role for the ingredient in hair and scalp formulation practice.<\/p>\n What it supports<\/b><\/p>\n \u00b7 Hair-conditioning positioning of the ingredient\u3000\u00b7 Scalp-care relevance<\/p>\n \u00b7 Documented use level: 0.1\u20130.25 wt%\u3000\u00b7 Precedent across hair\/scalp care formats<\/p>\n Important boundaries<\/b><\/p>\n \u00b7 The disclosed range is not PuriPharm’s recommended dosage\u3000\u00b7 A patent disclosure is not clinical evidence for PuriNMF<\/p>\n US5523078A. Cited as a published formulation precedent; the patentee is deliberately omitted. Recommended use levels: see PuriPharm technical documentation.<\/p>\n APPLICATION MATRIX<\/p>\n One hydration-conditioning platform across skincare, cleansing, scalp, and hair formats<\/p>\n Skin Care<\/b><\/p>\n Moisturizing essences \u00b7 serums \u00b7 toners \u00b7 gel creams \u00b7 moisturizing creams \u00b7 sheet masks \u00b7 sleeping masks \u00b7 body lotions \u00b7 hand creams<\/p>\n Cleansing<\/b><\/p>\n Facial cleansers \u00b7 cleansing balms \u00b7 body washes \u00b7 hand soaps<\/p>\n Positioning: post-cleansing comfort, reduced tightness<\/p>\n Scalp Care<\/b><\/p>\n Scalp serums \u00b7 scalp essences \u00b7 scalp sprays \u00b7 pre-wash treatments \u00b7 scalp masks<\/p>\n Positioning: NMF-inspired scalp hydration, leave-on comfort<\/p>\n Hair Care<\/b><\/p>\n Shampoos \u00b7 conditioners \u00b7 hair masks \u00b7 leave-in conditioners \u00b7 moisturizing mists \u00b7 hair serums \u00b7 curly-hair care \u00b7 chemically treated hair care<\/p>\n Positioning: hydration conditioning, softness, manageability<\/p>\n FORMULATION DESIGN<\/p>\n PuriNMF as the hydration-conditioning core \u2014 complementary formulation design<\/p>\n TECHNICAL SNAPSHOT<\/p>\n Verified identity data only \u2014 no invented specifications<\/p>\n Full technical documentation \u2014 appearance, assay, pH, solubility, recommended dosage, process guidance, storage, shelf life, packaging, and preservation \u2014 is available on request from PuriPharm Co. Ltd.<\/p>\n WHY PURINMF<\/p>\n The commercial value, in five points<\/p>\n 01\u3000NMF-inspired dual chemistry<\/b> \u2014 sugar-derived and amino-acid-derived functionality coexist in one condensate system \u2014 distinct from ordinary single-polyol humectants.<\/p>\n 02\u3000Two keratin systems<\/b> \u2014 one platform across skin, scalp, and hair \u2014 one continuous scientific narrative from facial care to fiber care.<\/p>\n 03\u3000An evidence-aligned story<\/b> \u2014 grounded in NMF biology, Raman water-state research, and published patent precedent \u2014 with clear boundaries around every claim.<\/p>\n 04\u3000Leave-on and rinse-off<\/b> \u2014 from cleansers and shampoos to essences, masks, mists, and scalp care \u2014 one ingredient, broad format coverage.<\/p>\n 05\u3000Claim discipline<\/b> \u2014 literature-anchored, technically confident language that R&D, regulatory, and brand-science teams can all rely on.<\/p>\n PuriActives\u00ae PuriNMF \u2014 an advanced hydration-conditioning platform for skin, scalp, and hair.<\/b><\/p>\n PURIPHARM CO. LTD.<\/p>\n Hydration conditioning inspired by NMF biology<\/p>\n Key References<\/b><\/p>\n Rawlings AV, Harding CR. Dermatol Ther. 2004;17(Suppl 1):43\u201348. \u00b7 Schleusener J, et al. Molecules. 2021;26(6):1649. DOI: 10.3390\/molecules26061649. \u00b7 Fluhr JW, et al. J Biophotonics. 2023;16:e202200201. DOI: 10.1002\/jbio.202200201. \u00b7 Final Report of the Safety Assessment of Polyamino Sugar Condensate. J Am Coll Toxicol. 1982;1(4):25\u201332. \u00b7 Raj PS, et al. Int J Toxicol. 2023;42(3 Suppl):91S\u201392S.<\/p>\n Patents<\/b><\/p>\n EP0535789A2 \u2014 Topical cleansing and conditioning compositions. \u00b7 US5523078A \u2014 Hair and scalp care.<\/p>\n Image Credits<\/b><\/p>\n OpenStax, Anatomy & Physiology (CC BY 4.0) \u00b7 CSIRO ScienceImage 8115 (CC BY 3.0) \u00b7 Foreade, Wikimedia Commons (CC BY-SA 4.0).<\/p>\n For technical documentation, samples, and formulation support, please contact PuriPharm Co. Ltd.<\/p>\n","protected":false},"excerpt":{"rendered":" PURIPHARM CO. 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