{"id":1948,"date":"2026-10-07T13:11:30","date_gmt":"2026-10-07T05:11:30","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=1948"},"modified":"2026-10-07T13:11:30","modified_gmt":"2026-10-07T05:11:30","slug":"nanoactive-rosursol","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=1948","title":{"rendered":"NanoActive RosUrsol™"},"content":{"rendered":"

NanoActive RosUrsol™<\/h2>\n

Rosemary Nano-Liposomes<\/b><\/p>\n

INCI \u2014 ROSMARINUS OFFICINALIS (ROSEMARY) EXTRACT \u00b7 enriched with high-purity ursolic acid and carnosic acid<\/p>\n

Botanical intelligence \u00b7 defined actives \u00b7 engineered delivery<\/p>\n

Powered by PURISOME\u00ae FlexVes™ liposome technology<\/p>\n

\"\"<\/p>\n

Phospholipid bilayer vesicle \u2014 the PURISOME\u00ae nano-liposome platform<\/p>\n

PuriPharm Co., Ltd.NanoActive™ \u00b7 PURISOME\u00ae<\/p>\n

01 \u00b7 POSITIONING<\/p>\n

From botanical extract to precision active platform<\/h2>\n

NanoActive RosUrsol™ is not an ordinary rosemary extract \u2014 it is a standardized botanical active delivery platform<\/b>.<\/p>\n

Rosemary<\/b> (Mediterranean botanical)\u3000\u2192\u3000Standardized actives<\/b> (ursolic acid \uff0b carnosic acid)\u3000\u2192\u3000NanoActive™<\/b> (water-compatible platform)<\/p>\n

Conventional rosemary extract<\/b><\/p>\n

\u00b7 Composition may vary from batch to batch<\/p>\n

\u00b7 Limited standardization of active constituents<\/p>\n

\u00b7 Lipophilic actives poorly compatible with water-based formulas<\/p>\n

\u00b7 Positioning dominated by the botanical story<\/p>\n

\u00b7 Performance strongly dependent on extraction process and base<\/p>\n

NanoActive RosUrsol™ rosemary nano-liposomes<\/b><\/p>\n

\u00b7 Enriched with defined, high-value phytochemicals<\/p>\n

\u00b7 High-purity ursolic acid + carnosic acid actives<\/p>\n

\u00b7 Water-compatible delivery concept<\/p>\n

\u00b7 Advanced lipid carrier technology<\/p>\n

\u00b7 Cosmetic and food application potential<\/p>\n

\u00b7 Science-driven positioning<\/p>\n

The name RosUrsol™<\/b> \u2014 Ros (rosemary) + Ursol (ursolic acid) \u2014 stands for a standardized rosemary-derived platform built on high-value lipophilic phytochemicals, with carnosic acid as the complementary active axis.<\/p>\n

01 \u00b7 POSITIONING<\/p>\n

RosUrsol™ at a glance<\/h2>\n

Four pillars define the platform \u2014 chemistry, delivery, biology and application breadth.<\/p>\n

Dual botanical actives<\/b><\/p>\n

Enriched with high-purity ursolic acid and carnosic acid \u2014 two chemically defined lipophilic rosemary phytochemicals.<\/p>\n

Water compatibility<\/b><\/p>\n

A water-dispersible delivery form designed for modern water-rich formulation systems.<\/p>\n

Multi-pathway biology<\/b><\/p>\n

Complementary mechanisms spanning skin tone, photo-stress, barrier, inflammation and neuro-skin biology.<\/p>\n

Cosmetics + food<\/b><\/p>\n

The same rosemary-derived defense chemistry serving skin care, scalp care and food-lipid protection.<\/p>\n

PRODUCT IDENTITY<\/b><\/p>\n

Product \u2014 NanoActive RosUrsol™ rosemary nano-liposomes \u00b7 INCI \u2014 rosemary extract (ROSEMARY EXTRACT)<\/p>\n

Active platform \u2014 a standardized rosemary-derived fraction enriched with high-purity ursolic acid and carnosic acid<\/p>\n

Technology \u2014 powered by PURISOME\u00ae FlexVes™ liposome technology<\/p>\n

02 \u00b7 PHYTOCHEMISTRY<\/p>\n

Rosemary \u2014 a phytochemical platform<\/h2>\n

RosUrsol™ focuses on the high-value lipophilic active space<\/b> of the rosemary leaf.<\/p>\n

\"\"<\/p>\n

Rosmarinus officinalis L. (Salvia rosmarinus), Lamiaceae \u2014 a chemically rich Mediterranean botanical.<\/p>\n

NanoActive RosUrsol™ focuses on the lipophilic fraction \u2014 ursolic acid + carnosic acid.<\/b><\/p>\n\n\n\n\n\n\n\n\n
Molecule<\/th>\nClass<\/th>\nFormula<\/th>\nMW<\/th>\nSolubility<\/th>\n<\/tr>\n
Ursolic acid<\/td>\nPentacyclic triterpene<\/td>\nC30H48O3<\/td>\n456.7<\/td>\nOil-soluble<\/td>\n<\/tr>\n
Carnosic acid<\/td>\nPhenolic diterpene<\/td>\nC20H28O4<\/td>\n332.4<\/td>\nOil-soluble<\/td>\n<\/tr>\n
Carnosol<\/td>\nPhenolic diterpene<\/td>\nC20H26O4<\/td>\n330.4<\/td>\nOil-soluble<\/td>\n<\/tr>\n
Rosmarinic acid<\/td>\nPhenolic acid<\/td>\nC18H16O8<\/td>\n360.3<\/td>\nWater-soluble<\/td>\n<\/tr>\n
Related phenolics<\/td>\nPolar fraction<\/td>\n\u2014<\/td>\n\u2014<\/td>\nWater-soluble<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Lipophilic fraction \u2014 the RosUrsol™ space<\/b>\u3000\u00b7\u3000Polar fraction \u2014 outside this platform’s scope<\/b><\/p>\n

Molecular data sources \u2014 PubChem (CID 64945, 65126) and published rosemary active specifications. Ursolic acid, carnosic acid, carnosol and rosmarinic acid are chemically distinct molecules.<\/p>\n

02 \u00b7 PHYTOCHEMISTRY<\/p>\n

Two signature molecules<\/h2>\n

Defined chemistry first \u2014 the foundation of standardization.<\/p>\n

\"\"<\/p>\n

URSOLIC ACID<\/b><\/p>\n

Pentacyclic triterpene<\/p>\n

C30H48O3 \u00b7 MW 456.7 \u00b7 XlogP 7.3<\/p>\n

CAS 77-52-1<\/p>\n

\"\"<\/p>\n

CARNOSIC ACID<\/b><\/p>\n

Phenolic diterpene<\/p>\n

C20H28O4 \u00b7 MW 332.4 \u00b7 XlogP 4.9<\/p>\n

CAS 3650-09-7<\/p>\n

Both are strongly lipophilic \u2014 delivery engineering is at the core of this platform.<\/b><\/p>\n

Structures from PubChem (CID 64945, 65126). Formulas and molecular weights verified against public specifications.<\/p>\n

03 \u00b7 DUAL-ACTIVE SCIENCE<\/p>\n

Two signature botanical actives, complementary biology<\/h2>\n

Each molecule covers different research territories; together they span skin defense, tone and structure.<\/p>\n

URSOLIC ACID<\/b>pentacyclic triterpene \u2014 research areas<\/p>\n

\u00b7 Melanophagy \u2014 melanosome clearance\u3000\u00b7 biology of pigmentation\u3000\u00b7 cellular stress response\u00b7 skin barrier \/ lipid biology\u3000\u00b7 ECM homeostasis\u3000\u00b7 inflammatory balance<\/p>\n

NanoActive RosUrsol™<\/b>an integrated botanical defense platform<\/p>\n

CARNOSIC ACID<\/b>phenolic diterpene \u2014 research areas<\/p>\n

\u00b7 Antioxidant defense \/ ROS modulation\u3000\u00b7 Nrf2 cellular defense\u3000\u00b7 photoaging \/ MMP regulation\u00b7 inflammatory signaling\u3000\u00b7 TRPA1 \/ neuro-skin biology\u3000\u00b7 lipid oxidation protection<\/p>\n

04 \u00b7 URSOLIC ACID<\/p>\n

Beyond melanin synthesis: supporting melanosome clearance<\/h2>\n

Published research points to a second axis of skin-tone biology \u2014 degradation, not only production<\/b>.<\/p>\n

\"\"<\/p>\n

Evidence level 2 \u00b7 primary research \u2014 ursolic acid, in vitro<\/b><\/p>\n

In \u03b1-MSH-stimulated B16F1 melanocytes, ursolic acid (5\u201310 \u00b5M) activated autophagy, promoted melanosome degradation and reduced melanin content.<\/p>\n

Bafilomycin A1, an autophagosome\u2013lysosome fusion inhibitor, blocked melanosome clearance; knockout of the autophagy gene ATG5 abolished the anti-pigment effect \u2014 establishing melanophagy as the mechanism.<\/p>\n

Park HJ et al. Biochem Biophys Res Commun. 2020;531(2):209\u2013214. PMID 32792197.<\/p>\n

04 \u00b7 URSOLIC ACID<\/p>\n

From mechanism to visible skin tone<\/h2>\n

Human evidence from an ursolic-acid-rich botanical system supports the relevance of ursolic-acid biology to skin tone.<\/p>\n

Axis 1 \u2014 production<\/b><\/p>\n

Melanogenesis regulation \u2014 tyrosinase and melanogenic regulators (TYRP-1, TYRP-2, MITF), demonstrated for ursolic-acid-rich systems in melanocyte models.<\/p>\n

Axis 2 \u2014 clearance<\/b><\/p>\n

Melanosome clearance \u2014 ursolic acid promotes melanosome autophagy (melanophagy) in B16F1 melanocytes (Park HJ et al. 2020).<\/p>\n

Dual-axis tone management \u2014 production and clearance together tell a more complete skin-tone science story.<\/b><\/p>\n

\"\"<\/p>\n

Annurca apple oil extract (AAO), standardized to 784 \u00b5g\/mL ursolic acid; 2.5% formulation, randomized double-blind placebo-controlled trial, n = 42, 28 days; all endpoints p < 0.001 vs placebo. Maisto M et al. Sci Rep. 2025. PMID 41387498.<\/p>\n

04 \u00b7 URSOLIC ACID<\/p>\n

Skin resilience: barrier lipids and ECM homeostasis<\/h2>\n

Ursolic-acid biology reaches beyond tone \u2014 into epidermal lipids and matrix balance.<\/p>\n

Barrier and epidermal lipid biology<\/b><\/p>\n

\u00b7 Topical ursolic acid accelerated epidermal permeability-barrier recovery (>20% vs control at 6 h) and induced keratinocyte differentiation via PPAR-\u03b1 \u2014 hairless-mouse and HaCaT models (Ahn SK et al. 2007, PMID 17727365).<\/p>\n

\u00b7 Liposome-encapsulated ursolic acid increased ceramides in cultured human keratinocytes and human skin, and collagen in dermal fibroblasts (Both DM et al. 2000, DOI 10.1159\/000053280).<\/p>\n

A liposomal precedent:<\/b> the ceramide\/collagen evidence above was generated with a liposomal ursolic-acid format \u2014 directly relevant to the PURISOME\u00ae delivery concept.<\/p>\n

ECM homeostasis \u2014 not a \u201ccollagen booster\u201d<\/b><\/p>\n

Healthy ECM = synthesis ↔ organization ↔ remodeling. Published evidence suggests context-dependent regulation of extracellular-matrix biology. RosUrsol™ therefore uses balanced language:<\/p>\n

\u00b7 ECM homeostasis \u00b7 matrix protection \u00b7 healthy matrix turnover \u00b7 firmer appearance<\/p>\n

Sweeping claims such as \u201cursolic acid always increases collagen\u201d are deliberately avoided \u2014 matrix biology is context-dependent.<\/p>\n

Evidence level 2 \u2014 primary ursolic-acid research (in vitro \/ animal \/ human-skin ceramide assessment).<\/p>\n

05 \u00b7 CARNOSIC ACID<\/p>\n

Where direct antioxidant chemistry meets cellular defense<\/h2>\n

Carnosic acid is not just \u201ca strong antioxidant\u201d \u2014 it defends on two complementary levels.<\/p>\n

Level 1 \u2014 direct defense<\/b><\/p>\n

\u00b7 Reacts directly with ROS and free radicals<\/p>\n

\u00b7 Lipid-phase antioxidant chemistry \u2014 protection where oxidation begins<\/p>\n

\u00b7 Readily oxidized itself: a chemical quencher consumed in defense<\/p>\n

Level 2 \u2014 biological defense<\/b><\/p>\n

\u00b7 Redox-sensitive cell signaling (Keap1\u2013Nrf2\u2013ARE)<\/p>\n

\u00b7 Activates endogenous defense enzymes<\/p>\n

\u00b7 Protection continues through its oxidized derivatives<\/p>\n

\"\"<\/p>\n

Evidence level 2 \u2014 primary carnosic-acid research<\/b><\/p>\n

Loussouarn M et al. Plant Physiology. 2017. PMID 28916593: when lipids are oxidized by ROS, carnosic acid is consumed and oxidized into derivatives including carnosol; EPR confirmed that carnosic acid \u2014 not carnosol \u2014 quenches ROS, while carnosol inhibits lipid peroxidation within the lipid phase. Carnosic acid does not remain chemically unchanged while acting as an antioxidant.<\/b><\/p>\n

05 \u00b7 CARNOSIC ACID<\/p>\n

Helping cells build their own defense<\/h2>\n

The Keap1\u2013Nrf2\u2013ARE pathway \u2014 the cell’s own antioxidant program, switched on by redox-activated carnosic acid.<\/p>\n

\"\"<\/p>\n

What it means for skin<\/b><\/p>\n

\u00b7 Nrf2 is the master regulator of the cellular antioxidant response<\/p>\n

\u00b7 Activation brings endogenous, durable defense capacity \u2014 not one-off radical quenching<\/p>\n

\u00b7 Supports photo-stress defense, skin resilience and healthy-aging positioning<\/p>\n

Evidence discipline<\/b><\/p>\n

\u00b7 Keap1\u2013Nrf2 activation by carnosic acid is established in experimental cell and neuronal models (Satoh T et al. J Neurochem. 2008)<\/p>\n

\u00b7 Confirming skin relevance in fibroblasts and keratinocytes is a priority of the RosUrsol™ research program<\/p>\n

Evidence level 2\/4 \u2014 pathway literature; neuronal Nrf2 data are not presented as human-skin clinical evidence. Pathway diagram redrawn.<\/p>\n

05 \u00b7 CARNOSIC ACID<\/p>\n

Interrupting the UV\u2013ROS\u2013MMP cascade<\/h2>\n

Photoaging is a signaling cascade \u2014 carnosic acid intervenes at two defined nodes.<\/p>\n

\"\"<\/p>\n

What human skin-cell studies show<\/b><\/p>\n

\u00b7 Carnosic acid significantly and concentration-dependently inhibited UVA- and UVB-induced MMP-1, MMP-3 and MMP-9 expression in human dermal fibroblasts (Hs68)<\/p>\n

\u00b7 UVB-induced ROS generation was attenuated; ERK activation and AP-1 formation were suppressed<\/p>\n

\u00b7 EGFR activation was unaffected \u2014 suggesting selectivity within the upstream cascade<\/p>\n

\u00b7 UVB-enhanced GADD45 expression (a marker of oxidative DNA damage) was significantly reduced<\/p>\n

Park M et al. Exp Dermatol. 2013;22(5):336\u2013341. DOI 10.1111\/exd.12138. PMID 23614740. Cascade diagram redrawn; evidence level 2 \u2014 human skin-cell research.<\/p>\n

05 \u00b7 CARNOSIC ACID<\/p>\n

The evidence in human skin cells<\/h2>\n

Park M et al. 2013 \u2014 the key dataset behind the carnosic-acid anti-photoaging story.<\/p>\n

Study design<\/b><\/p>\n

\u00b7 Compound<\/b> \u2014 carnosic acid (rosemary phenolic diterpene)<\/p>\n

\u00b7 Models<\/b> \u2014 Hs68 dermal fibroblasts; primary normal human dermal fibroblasts; normal human epidermal keratinocytes<\/p>\n

\u00b7 Stimulus<\/b> \u2014 UVA \/ UVB irradiation<\/p>\n

\u00b7 Readouts<\/b> \u2014 Western blot, qRT-PCR, enzyme-activity assays<\/p>\n

Key findings<\/b><\/p>\n

\u00b7 MMP inhibition<\/b> \u2014 concentration-dependent inhibition of UV-induced MMP-1, MMP-3, MMP-9<\/p>\n

\u00b7 Signal blockade<\/b> \u2014 suppressed UVB-induced ERK activation and AP-1 formation<\/p>\n

\u00b7 ROS attenuation<\/b> \u2014 reduced UVB-induced ROS generation; EGFR unaffected<\/p>\n

\u00b7 DNA-damage marker<\/b> \u2014 UVB-enhanced GADD45 significantly reduced<\/p>\n

\u00b7 Cross-model confirmation<\/b> \u2014 fibroblast line, primary fibroblasts and keratinocytes<\/p>\n

Park M et al. Exp Dermatol. 2013;22(5):336\u2013341. DOI 10.1111\/exd.12138. PMID 23614740. Evidence level 2 \u2014 human skin-cell research; not finished-product data for NanoActive RosUrsol™.<\/p>\n

05 \u00b7 CARNOSIC ACID<\/p>\n

Calming stress signals upstream<\/h2>\n

Carnosic acid acts on the signaling chain that drives inflammatory mediators \u2014 not merely at the downstream end.<\/p>\n

\"\"<\/p>\n

Validated in skin-relevant models<\/b><\/p>\n

\u00b7 HaCaT keratinocytes \u2014 inhibited IL-6, IL-8 and MCP-1 under SLS \/ retinoic-acid stimulation<\/p>\n

\u00b7 RAW264.7 macrophages \u2014 blocked NO, TNF-\u03b1 and PGE\u2082 release upon TLR2 \/ TLR4 activation<\/p>\n

Positioning territories<\/b><\/p>\n

\u00b7 Environmentally stressed skin\u3000\u00b7 inflammaging & skin resilience\u3000\u00b7 sensitive-skin positioning\u3000\u00b7 scalp stress & the follicular environment<\/p>\n

Oh J et al. Mediators Inflamm. 2012;2012:781375. DOI 10.1155\/2012\/781375. PMID 22577255. Pathway diagram redrawn; evidence level 2. Cosmetic concept only \u2014 no disease-treatment claims.<\/p>\n

05 \u00b7 CARNOSIC ACID<\/p>\n

Activating the neuro-skin dialogue<\/h2>\n

A 2025 discovery links carnosic acid to TRPA1, a cutaneous sensory-neuron channel \u2014 a forward-looking science story.<\/p>\n

\"\"<\/p>\n

Experimental findings<\/b><\/p>\n

\u00b7 Topical rosemary extract accelerated wound closure and reduced fibrosis in an adult mouse wound model<\/p>\n

\u00b7 Carnosic acid was identified as the key active acting via TRPA1<\/p>\n

\u00b7 Mice lacking TRPA1 in sensory neurons lost the pro-regenerative response<\/p>\n

Translation into cosmetic language<\/b><\/p>\n

\u00b7 skin regenerative biology\u3000\u00b7 neuro-skin communication\u3000\u00b7 skin recovery & resilience\u3000\u00b7 tissue-renewal biology<\/p>\n

Rapp E et al. JCI Insight. 2025:e196267. DOI 10.1172\/jci.insight.196267. PMID 41129748.<\/p>\n

05 \u00b7 CARNOSIC ACID<\/p>\n

2025 regenerative biology: the spotlight study<\/h2>\n

Rapp E et al., JCI Insight 2025 \u2014 how a topical rosemary extract talks to sensory neurons.<\/p>\n

01A screen pinpointed the signal<\/b><\/p>\n

Among multiple botanical extracts, rosemary specifically activated the TRPA1 ion channel \u2014 the channel behind the regenerative response in the mouse ear-wound model.<\/p>\n

02Carnosic acid is the key active<\/b><\/p>\n

Carnosic acid \u2014 the principal bioactive of rosemary leaf \u2014 acts as a TRPA1 agonist on cutaneous sensory neurons, connecting phytochemistry to neuro-skin signaling.<\/p>\n

03TRPA1 dependence confirmed<\/b><\/p>\n

Mice lacking TRPA1 in sensory neurons showed no rosemary-induced regenerative response \u2014 mechanistic specificity, not a generic botanical effect.<\/p>\n

What it means for ROSURSOL™<\/b><\/p>\n

\u00b7 One defined molecule \u2014 carnosic acid \u2014 carries the activity, supporting the \u201cstandardized active\u201d positioning<\/p>\n

\u00b7 Opens a credible neuro-skin and skin-recovery narrative for premium skin and scalp care<\/p>\n

\u00b7 Shows how fast rosemary science is advancing \u2014 and why defined actives matter<\/p>\n

Claims discipline.<\/b>These are experimental mouse findings. RosUrsol™ communication language is regenerative biology, recovery and resilience \u2014 never wound or scar treatment.<\/p>\n

06 \u00b7 INTEGRATED SKIN BIOLOGY<\/p>\n

One platform, multi-pathway defense<\/h2>\n

The integrated biology map \u2014 two molecules, complementary territories, shared outcomes.<\/p>\n

Ursolic acid<\/b><\/p>\n

Melanophagy\u3000\u00b7\u3000barrier lipids\u3000\u00b7\u3000ECM homeostasis\u3000\u00b7\u3000inflammatory balance<\/p>\n

NanoActive RosUrsol™<\/b><\/p>\n

Carnosic acid<\/b><\/p>\n

Nrf2 defense\u3000\u00b7\u3000UV\u2013MMP protection\u3000\u00b7\u3000inflammatory signaling\u3000\u00b7\u3000TRPA1 biology<\/p>\n

SHARED OUTCOME TERRITORIES<\/b><\/p>\n

Skin resilience \u00b7 even skin tone \u00b7 photo-stress defense \u00b7 healthy aging \u00b7 skin recovery<\/p>\n

07 \u00b7 DELIVERY ENGINEERING<\/p>\n

Powerful actives, inconvenient physics<\/h2>\n

Ursolic acid and carnosic acid are both strongly lipophilic \u2014 excellent chemistry, inconvenient formulation behavior.<\/p>\n

7.3<\/b>XlogP \u2014 ursolic acid \u00b7 strongly lipophilic triterpene<\/p>\n

4.9<\/b>XlogP \u2014 carnosic acid \u00b7 lipophilic phenolic diterpene<\/p>\n

The conventional challenges<\/b><\/p>\n

High-value lipophilic phytochemicals\u2193 poor water compatibility\u2193 limited formulation versatility\u2193 difficult dispersion\u2193 crystallization \/ precipitation risk\u2193 hard to use in clear or water-rich systems<\/p>\n

The formulation paradox:<\/b> the very property that makes these molecules powerful \u2014 lipid affinity \u2014 keeps them out of the water-rich systems that dominate modern skin care and food innovation.<\/p>\n

07 \u00b7 DELIVERY ENGINEERING<\/p>\n

Turning lipophilic botanical actives into a water-compatible platform<\/h2>\n

The NanoActive™ answer: change how the active behaves in a formula through delivery engineering.<\/p>\n

\"\"<\/p>\n

Concept schematic \u2014 a lipophilic active carried within a phospholipid bilayer vesicle.<\/p>\n

Advanced delivery engineering\u3000\u2192\u3000water-compatible dispersion platform\u3000\u2192\u3000expanded formulation possibilities<\/b><\/p>\n

\u00b7 The active resides in a lipid-compatible vesicular environment<\/p>\n

\u00b7 Disperses uniformly in water-rich and multiphase systems<\/p>\n

\u00b7 Protects oxidation- and degradation-prone molecules<\/p>\n

\u00b7 Compatible with serums, lotions, emulsions and scalp formats<\/p>\n

07 \u00b7 DELIVERY ENGINEERING<\/p>\n

PURISOME\u00ae FlexVes™ liposome technology<\/h2>\n

PuriPharm’s proprietary advanced nano-liposome platform \u2014 the technical core of every NanoActive™ product.<\/p>\n

\"\"<\/p>\n

Phospholipid bilayer vesicle encapsulating lipophilic actives (schematic).<\/p>\n

Built on more than a decade of nano-delivery R&D and industrialization experience, PURISOME\u00ae encapsulates actives in skin-affine phospholipid bilayer vesicles \u2014 delivering four core values.<\/p>\n

1 \u00b7 Protection<\/b>\u3000shields oxidation- and degradation-prone actives; supports shelf-life stability.<\/p>\n

2 \u00b7 Delivery<\/b>\u3000enhances stratum-corneum penetration and bioavailability.<\/p>\n

3 \u00b7 Sustained release<\/b>\u3000controlled, sustained release that reduces irritation potential.<\/p>\n

4 \u00b7 Formulation compatibility<\/b>\u3000improves formulation versatility and sensory performance.<\/p>\n

07 \u00b7 DELIVERY ENGINEERING<\/p>\n

Designed for the skin interface<\/h2>\n

Nano-scale carriers interact with skin differently \u2014 particle size, surface film and lipid affinity all play a role.<\/p>\n

\"\"<\/p>\n

Skin cross-sections \u2014 smaller carrier systems distribute deeper into skin (concept schematic, carrier literature).<\/p>\n

\"\"<\/p>\n

Reducing particle size increases effective nanocarrier concentration and surface contact (concept schematic).<\/p>\n

\u00b7 Lipid affinity<\/b> \u2014 phospholipid vesicles are structurally compatible with the skin’s own lipid architecture<\/p>\n

\u00b7 Flexible vesicles<\/b> \u2014 FlexVes™ vesicles are designed to interact with the stratum-corneum interface<\/p>\n

\u00b7 Surface film & reservoir<\/b> \u2014 nanocarriers can deposit on the surface to form reservoirs, supporting sustained availability<\/p>\n

\u00b7 Protection in transit<\/b> \u2014 encapsulation shields oxidation-prone carnosic acid until application<\/p>\n

Conceptual delivery-system schematics (evidence level 4 \u2014 carrier literature).<\/p>\n

08 \u00b7 COSMETIC APPLICATIONS<\/p>\n

Scalp and follicle care<\/h2>\n

The follicular unit offers topical carrier systems a unique pathway \u2014 and a reservoir.<\/p>\n

Nanoparticle deposition along the follicular pathway<\/b><\/p>\n

\"\"<\/p>\n

The follicular unit as a delivery reservoir<\/b><\/p>\n

\"\"<\/p>\n

Concept schematics \u2014 PuriPharm technical library.<\/p>\n

The scalp stress environment<\/b><\/p>\n

\u00b7 Scalp oxidative stress and UV exposure<\/p>\n

\u00b7 Sebum-lipid oxidation at follicular openings<\/p>\n

\u00b7 Inflammatory stress in the follicular microenvironment<\/p>\n

\u00b7 Delivering lipophilic phytochemicals to where they are truly needed<\/p>\n

NanoActive RosUrsol™ \u2014 a dual-active antioxidant and resilience platform for premium scalp care.<\/b><\/p>\n

Scalp-vitality positioning; no hair-growth or hair-loss treatment claims.<\/p>\n

08 \u00b7 COSMETIC APPLICATIONS<\/p>\n

Cosmetic application territories<\/h2>\n

One active platform, four formulation territories \u2014 all compatible with modern water-rich formats.<\/p>\n

Skin tone & clarity<\/b><\/p>\n

\u00b7 tone-evening serums\u3000\u00b7 post-blemish mark care\u3000\u00b7 brightening serums\u3000\u00b7 dull-skin care<\/p>\n

Photoaging & anti-aging<\/b><\/p>\n

\u00b7 antioxidant serums\u3000\u00b7 daily environmental-defense serums\u3000\u00b7 anti-photoaging creams\u3000\u00b7 overnight repair serums\u3000\u00b7 mature-skin care<\/p>\n

Barrier & resilience<\/b><\/p>\n

\u00b7 barrier-support serums\u3000\u00b7 stressed-skin care\u3000\u00b7 lipid-repair creams\u3000\u00b7 sensitive-skin formulas<\/p>\n

Scalp care<\/b><\/p>\n

\u00b7 scalp antioxidant serums\u3000\u00b7 scalp anti-aging serums\u3000\u00b7 follicular-environment care\u3000\u00b7 oil-control \/ oxidative-stress scalp formats<\/p>\n

Application territories are based on the published ursolic-acid \/ carnosic-acid evidence base and PURISOME\u00ae delivery logic.<\/p>\n

09 \u00b7 FOOD SCIENCE<\/p>\n

From skin lipids to food lipids<\/h2>\n

One botanical system, two protective environments.<\/p>\n

\"\"<\/p>\n

09 \u00b7 FOOD SCIENCE<\/p>\n

Lipid oxidation: the cascade that spoils food<\/h2>\n

Understanding the free-radical chain is the basis of every antioxidant strategy.<\/p>\n

1 \u00b7 Initiation<\/b>LH \u2192 L\u2022<\/p>\n

Heat, light or trace metals abstract hydrogen from unsaturated lipids.<\/p>\n

2 \u00b7 Propagation<\/b>L\u2022 + O\u2082 \u2192 LOO\u2022\u3000\u00b7\u3000LOO\u2022 + LH \u2192 LOOH + L\u2022<\/p>\n

A self-propagating free-radical chain.<\/p>\n

3 \u00b7 Decomposition<\/b>LOOH \u2192 aldehydes \u00b7 ketones<\/p>\n

Volatile oxidation products form.<\/p>\n

Consequences<\/b><\/p>\n

Rancidity \u00b7 off-odors \u00b7 aroma deterioration \u00b7 color instability \u00b7 loss of polyunsaturated fatty acids \u00b7 nutritional degradation<\/p>\n

Rosemary diterpenes are lipid-phase defense molecules \u2014 they act where the cascade begins: inside the lipid matrix.<\/b><\/p>\n

09 \u00b7 FOOD SCIENCE<\/p>\n

Protection where oxidation begins \u2014 the lipid phase<\/h2>\n

Carnosic acid is the first-line quencher; its oxidized derivatives extend the defense network.<\/p>\n

\"\"<\/p>\n

Mechanistic basis<\/b><\/p>\n

\u00b7 Carnosic acid scavenges singlet oxygen and free radicals, and is oxidized into derivatives including carnosol<\/p>\n

\u00b7 Carnosol acts directly in the lipid phase, inhibiting peroxidation and stabilizing membrane structures<\/p>\n

\u00b7 This relay broadens the action spectrum \u2014 a cascade antioxidant system documented in planta and in lipid models<\/p>\n

Relevance to food systems<\/b><\/p>\n

\u00b7 Free-radical quenching chemistry in the lipid phase<\/p>\n

\u00b7 Protects unsaturated fatty acids and oxidation-sensitive lipid systems<\/p>\n

\u00b7 Conversion into antioxidant-relevant derivatives extends protection over time<\/p>\n

\u00b7 Rosemary antioxidant diterpenes are compositional markers of food-grade rosemary extract<\/p>\n

Loussouarn M et al. Plant Physiology. 2017. PMID 28916593. Evidence level 2\/3 \u2014 primary rosemary-diterpene research. Mechanism diagram redrawn.<\/p>\n

09 \u00b7 FOOD SCIENCE<\/p>\n

The food application space<\/h2>\n

At the heart of the food story is oxidative stability \u2014 flavor, color, nutritional quality and shelf-life support.<\/p>\n

Edible oils & fats<\/b><\/p>\n

\u00b7 PUFA-rich oils\u3000\u00b7 specialty oils\u3000\u00b7 blended oils\u3000\u00b7 functional lipids<\/p>\n

Meat & savory products<\/b><\/p>\n

\u00b7 meat products\u3000\u00b7 processed meats\u3000\u00b7 emulsified meat systems\u3000\u00b7 fat-containing savory foods<\/p>\n

Bakery & fats<\/b><\/p>\n

\u00b7 bakery fats\u3000\u00b7 fillings\u3000\u00b7 nut-based systems\u3000\u00b7 fat-containing snacks<\/p>\n

Nutritional products<\/b><\/p>\n

\u00b7 lipid-based nutritional products\u3000\u00b7 functional food formulations\u3000\u00b7 oxidation-sensitive nutritional systems<\/p>\n

Regulatory context \u2014 rosemary extract<\/b><\/p>\n

Rosemary extract has an established regulatory heritage as a food antioxidant \u2014 E392 (extracts of rosemary) in the EU, with carnosic acid and carnosol as its key compositional markers. That heritage applies to the rosemary-extract category; the specific regulatory status of NanoActive RosUrsol™ \u2014 botanical source, process, carrier system, nano character, target food categories and labeling \u2014 must be verified jurisdiction by jurisdiction. No automatic equivalence to E392 is claimed.<\/b><\/p>\n

09 \u00b7 FOOD SCIENCE<\/p>\n

Water-compatible formats open new matrix space<\/h2>\n

An R&D platform opportunity \u2014 to be validated matrix by matrix, jurisdiction by jurisdiction.<\/p>\n

The conventional limitation<\/b><\/p>\n

Lipophilic rosemary antioxidants excel in lipid phases \u2014 but are difficult to introduce uniformly into water-rich or multiphase systems.<\/p>\n

The ROSURSOL™ opportunity space<\/b><\/p>\n

\u00b7 Emulsions and nutritional emulsions<\/p>\n

\u00b7 Sauces and aqueous premixes<\/p>\n

\u00b7 Multiphase food matrices<\/p>\n

\u00b7 Beverages \u2014 where technology and regulation permit<\/p>\n

10 \u00b7 SUMMARY<\/p>\n

Why NanoActive RosUrsol™<\/h2>\n

Five essentials \u2014 and one claims architecture spanning cosmetics and food.<\/p>\n

01<\/b>\u3000Standardized rosemary phytochemistry \u2014 not a variable generic botanical extract<\/p>\n

02<\/b>\u3000Ursolic acid + carnosic acid \u2014 two defined, high-value actives<\/p>\n

03<\/b>\u3000Complementary biological defense \u2014 multi-pathway coverage without synergy inflation<\/p>\n

04<\/b>\u3000A water-compatible delivery platform \u2014 PURISOME\u00ae FlexVes™ liposome technology<\/p>\n

05<\/b>\u3000Cosmetic + food innovation potential \u2014 one chemistry, two industries<\/p>\n

THE CLAIMS ARCHITECTURE \u2014 DUAL BOTANICAL ACTIVES, MULTI-SYSTEM PROTECTION<\/b><\/p>\n

Cosmetic science<\/b>\u3000antioxidant defense \u00b7 photo-stress protection \u00b7 skin resilience \u00b7 even skin tone \u00b7 ECM homeostasis \u00b7 skin regenerative biology \u00b7 scalp defense<\/p>\n

Food science<\/b>\u3000lipid protection \u00b7 oxidative stability \u00b7 quality preservation \u00b7 flavor protection \u00b7 color stability \u00b7 PUFA protection \u00b7 shelf-life support<\/p>\n

NanoActive RosUrsol™ rosemary nano-liposomes \u00b7 PURISOME\u00ae FlexVes™ liposome technologyPuriPharm Co., Ltd. \u00b7 www.puriactives.com<\/p>\n

10 \u00b7 SUMMARY \u00b7 REFERENCES<\/p>\n

References<\/h2>\n

1 \u00b7 Park HJ et al. Ursolic acid inhibits pigmentation by increasing melanosomal autophagy in B16F1 cells. Biochem Biophys Res Commun. 2020;531(2):209\u2013214. DOI 10.1016\/j.bbrc.2020.07.125 \u00b7 PMID 32792197<\/p>\n

2 \u00b7 Maisto M et al. Apple oil as a source of ursolic acid for the treatment of hyperpigmentary disorders with molecular and clinical evaluation. Sci Rep. 2025. PMID 41387498<\/p>\n

3 \u00b7 Ahn SK et al. Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via PPAR-\u03b1. J Dermatol. 2007. PMID 17727365<\/p>\n

4 \u00b7 Both DM, Goodtzova K, Yarosh DB, Brown DA. Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells. Horm Res. 2000;54(5\u20136):318\u2013321. DOI 10.1159\/000053280<\/p>\n

5 \u00b7 Loussouarn M et al. Carnosic acid and carnosol, two major antioxidants of rosemary, act through different mechanisms. Plant Physiology. 2017. PMID 28916593<\/p>\n

6 \u00b7 Park M et al. Carnosic acid, a phenolic diterpene from rosemary, prevents UV-induced expression of matrix metalloproteinases in human skin fibroblasts and keratinocytes. Exp Dermatol. 2013;22(5):336\u2013341. DOI 10.1111\/exd.12138 \u00b7 PMID 23614740<\/p>\n

7 \u00b7 Oh J et al. Syk\/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid. Mediators Inflamm. 2012;2012:781375. DOI 10.1155\/2012\/781375 \u00b7 PMID 22577255<\/p>\n

8 \u00b7 Rapp E et al. Carnosic acid in topical rosemary extract enhances skin repair via TRPA1 activation. JCI Insight. 2025:e196267. DOI 10.1172\/jci.insight.196267 \u00b7 PMID 41129748<\/p>\n

9 \u00b7 Satoh T et al. Carnosic acid activates the Keap1\/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem. 2008.<\/p>\n

10 \u00b7 Commission Regulation (EU) No 231\/2012 \u2014 specifications for food additives; E392 extracts of rosemary.<\/p>\n

Image credits \u2014 vesicle schematics, skin cross-sections and follicular schematics, molecular structures \u2014 PuriPharm technical library (company archive); structure data from PubChem.<\/p>\n","protected":false},"excerpt":{"rendered":"

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