{"id":2083,"date":"2026-10-08T18:44:06","date_gmt":"2026-10-08T10:44:06","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=2083"},"modified":"2026-10-08T18:44:06","modified_gmt":"2026-10-08T10:44:06","slug":"puriactives-rhamnocalm","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=2083","title":{"rendered":"PuriActives\u00ae RhamnoCalm™"},"content":{"rendered":"

01 \u00b7 PuriActives\u00ae RhamnoCalm™: Rhamnose-Rich Soothing Polysaccharide<\/h2>\n

A rhamnose-rich biofunctional polysaccharide linking glycobiology with skin and scalp soothing. Recognizing cellular signals for targeted soothing.<\/p>\n

Key active: Biosaccharide Gum-2. A functional cosmetic active based on glycobiological cell recognition.<\/p>\n

PuriPharm Co. Ltd. (\u6d66\u745e\u751f\u7269\u533b\u836f\u6280\u672f\u6709\u9650\u516c\u53f8).<\/p>\n

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02 \u00b7 Product at a Glance: Biotechnology in the Language of Skin<\/h2>\n

Trade name: PuriActives\u00ae RhamnoCalm™. Key active: Biosaccharide Gum-2.<\/p>\n

Category: a biotechnology-derived functional polysaccharide active for soothing cosmetic formulations.<\/p>\n

Positioning: sensitive skin soothing, rapid redness reduction, anti-irritant care, neuro-comfort, inflammatory signal modulation, support for tolerance of potent actives, healthy aging, and scalp soothing and stress management.<\/p>\n

Central idea: rhamnose-rich polysaccharides interact with biological recognition mechanisms in keratinocytes to soothe stressed skin and scalp and support lasting resilience. Rhamnose-powered biological soothing.<\/p>\n

Image: illustrative textures for serums, gels, and creams.<\/p>\n

03 \u00b7 Why Skin Becomes Sensitive: The Biological Pathway of Discomfort<\/h2>\n

Before redness becomes visible, daily stressors can already trigger alarm signals in epidermal cells.<\/p>\n

Stressors include UV and pollution, surfactant cleansing, retinol and exfoliating acids, chemical hair coloring or perming, heat, friction and shaving, dryness and barrier stress, and lifestyle or urban stress.<\/p>\n

Pathway: environmental and chemical stress on facial or scalp epidermis \u2192 keratinocyte activation \u2192 IL-1\u03b1 release and initiation of inflammation \u2192 neutrophil recruitment and adhesion \u2192 the PLA2, arachidonic acid, and PGE2 cascade \u2192 erythema, warmth, and visible discomfort.<\/p>\n

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04 \u00b7 Key Active: A Rhamnose-Rich Branched Biosaccharide<\/h2>\n

Biosaccharide Gum-2 is a biotechnology-derived extracellular polysaccharide produced through modern fermentation, with a branched structure rich in rhamnose residues.<\/p>\n

Its biofunctional concept centers on skin\u2013glycan interactions, with sugar units recognized at the keratinocyte surface.<\/p>\n

L-rhamnose (Rha): a recognition unit interacting with lectin-like carbohydrate recognition sites.<\/p>\n

D-galactose (Gal): a structural unit of the branched glycan backbone.<\/p>\n

Glucuronic acid (GlcA): an acidic sugar unit contributing to the glycan\u2019s biological properties.<\/p>\n

These related sugar units together define the interaction profile. The branched structure is schematic, with darker units indicating rhamnose-rich recognition motifs.<\/p>\n

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05 \u00b7 Glycobiological Cell Recognition<\/h2>\n

Human keratinocytes have membrane-associated lectins and carbohydrate recognition systems that can interact with rhamnose-containing glycans.<\/p>\n

Rhamnose-rich Biosaccharide Gum-2 \u2192 interaction with cell-surface lectin\/carbohydrate recognition sites \u2192 modulation of intercellular communication \u2192 reduced spread of irritation responses \u2192 less redness and discomfort, with restored comfort and resilience.<\/p>\n

This is a recognition-based glycobiological concept, not a pharmacological receptor claim.<\/p>\n

Image: fluorescence microscopy of human skin cells.<\/p>\n

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06 \u00b7 Rhamnose\u2013Keratinocyte Communication<\/h2>\n

Cell affinity encoded in glycans: the schematic shows rhamnose-containing units in dark blue interacting with lectin-like carbohydrate recognition sites in gold.<\/p>\n

Image: a 3D model of epidermal keratinocyte layers.<\/p>\n

Scientific basis: Condaminet et al., Experimental Cell Research, 1997, supports the basis for recognition of \u03b1-L-rhamnosyl structures by surface lectins on keratinocytes. DOI: 10.1006\/excr.1997.3518. [1]<\/p>\n

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07 \u00b7 Inflammatory Signal Network: Five Intervention Points<\/h2>\n

External stress (UV, surfactants, coloring or perming) \u2192 keratinocyte activation \u2192 IL-1\u03b1\/TNF-\u03b1 release \u2192 inflammatory cell recruitment \u2192 neutrophil adhesion \u2192 PLA2 activation \u2192 membrane phospholipid and arachidonic acid pathways \u2192 COX \u2192 PGE2 \u2192 erythema and warmth.<\/p>\n

Five intervention points: modulate the initiating IL-1\u03b1 signal, reduce neutrophil adhesion, inhibit PLA2 activity, modulate PGE2 signaling, and promote \u03b2-endorphin release for neuro-comfort.<\/p>\n

Signals amplify from external stress to visible redness, and RhamnoCalm™ is positioned for soothing at several nodes.<\/p>\n

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08 \u00b7 Multi-Target Soothing: Five Mechanisms<\/h2>\n

Main pathway: cellular stress \u2192 keratinocyte activation \u2192 IL-1\u03b1 \u2192 neutrophil adhesion \u2192 the PLA2\/arachidonic acid cascade \u2192 PGE2 \u2192 erythema, warmth, and discomfort.<\/p>\n

1. Modulate initiation by reducing keratinocyte IL-1\u03b1 signaling.<\/p>\n

2. Reduce neutrophil adhesion and further signal propagation.<\/p>\n

3. Inhibit PLA2 to modulate the arachidonic acid cascade upstream.<\/p>\n

4. Modulate PGE2 to help reduce redness, warmth, and discomfort.<\/p>\n

5. A parallel neuro-comfort pathway promotes keratinocyte \u03b2-endorphin release to support comfort beyond inflammatory signaling.<\/p>\n

The concept covers a cascade at multiple levels rather than a single inflammatory endpoint.<\/p>\n

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09 \u00b7 In Vitro Reference Data: IL-1\u03b1<\/h2>\n

Model: reconstructed human epidermis stimulated with 0.025% tretinoin cream.<\/p>\n

The rhamnose-rich polysaccharide reference system reduced induced IL-1\u03b1 by approximately 11% at 0.66% and 28% at 2%.<\/p>\n

This relates to modulation of sensitivity signals at the onset of inflammation.<\/p>\n

Source: in vitro reference research on rhamnose-rich Biosaccharide Gum-2. In vitro data do not represent clinical efficacy of finished products.<\/p>\n

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10 \u00b7 In Vitro Reference Data: Neutrophil Adhesion<\/h2>\n

Keratinocytes were stimulated with LPS, then fluorescence-labeled human neutrophils were added to measure adhesion.<\/p>\n

The reference system reduced adhesion by approximately 22% at 1% and 40% at 2%. Reduced adhesion can help limit continued inflammatory signal propagation.<\/p>\n

Image: a reference light microscopy image of keratinocytes.<\/p>\n

Source: in vitro reference research on rhamnose-rich Biosaccharide Gum-2.<\/p>\n

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11 \u00b7 In Vitro Reference Data: Upstream PLA2 Modulation<\/h2>\n

Phospholipase A2 (PLA2) is a key upstream enzyme in the arachidonic acid inflammatory cascade: cell membrane phospholipids \u2192 PLA2 \u2192 arachidonic acid \u2192 COX \u2192 PGE2 \u2192 visible erythema, warmth, and discomfort.<\/p>\n

At approximately 0.5%, the reference system reduced PLA2 activity by about 38%\u201340%, with relatively stable inhibition over the 0.5%\u20132% test range.<\/p>\n

RhamnoCalm™ is positioned for upstream intervention in the visible redness cascade.<\/p>\n

Source: reference in vitro enzyme research on rhamnose-rich Biosaccharide Gum-2.<\/p>\n

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12 \u00b7 In Vitro Reference Data: PGE2<\/h2>\n

Prostaglandin E2 (PGE2) is an important mediator of skin erythema, warmth, irritation, and inflammatory discomfort.<\/p>\n

Model A, human neutrophils: a 1% reference system reduced PGE2 synthesis by approximately 32%.<\/p>\n

Model B, keratinocytes: another reference system at a higher test concentration reported a maximum decrease of approximately 69% in PGE2 release.<\/p>\n

These are independent models and must not be combined into a single dose\u2013response curve. Modulation occurs at several levels from enzymes to mediators.<\/p>\n

Source: in vitro reference research on rhamnose-rich Biosaccharide Gum-2.<\/p>\n

13 \u00b7 Neuro-Comfort: \u03b2-Endorphin Release<\/h2>\n

Keratinocytes participate in the skin\u2019s neuroimmune and endocrine network. Rhamnose-rich polysaccharide signaling promotes \u03b2-endorphin release, which is associated with comfort and modulation of pain signaling.<\/p>\n

Reference data after 36 hours of in vitro keratinocyte culture: release increased approximately 46% with the 1% system and 55% with the 5% system. The presentation reports statistical significance without a specific p-value.<\/p>\n

Conceptual pathway: keratinocytes \u2192 \u03b2-endorphin release \u2192 greater comfort and fewer discomfort signals.<\/p>\n

Patent WO2004078789A1 describes rhamnose-containing branched polysaccharides with high keratinocyte affinity that can promote \u03b2-endorphin release, together with cosmetic compositions and uses. [4]<\/p>\n

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14 \u00b7 Human Reference Data: Redness Reduction at 2 Hours<\/h2>\n

UV-induced erythema reference study: 20 volunteers, UV-induced redness on the back, and a cream containing 5% of the test system compared with placebo.<\/p>\n

Instrumental measurement of the a* erythema parameter at 2 hours showed an average decrease of approximately 44% in visible redness among the relevant participants.<\/p>\n

Source: a human reference study of rhamnose-rich Biosaccharide Gum-2, not direct clinical data for a finished product.<\/p>\n

15 \u00b7 Sensitive and Active Skin Care: Soothing and Tolerance Support<\/h2>\n

The IL-1\u03b1 study in tretinoin-stimulated reconstructed epidermis provides a formulation rationale for pairing rhamnose-rich soothing polysaccharides with potent actives. The source positions the product to preserve active performance while improving irritation, tightness, redness, and overall comfort.<\/p>\n

Concepts include retinol\/retinal, AHA\/BHA\/PHA exfoliation, high-concentration vitamin C, brightening actives, acne-prone skin care, and soothing cosmetics after irritating care procedures.<\/p>\n

Other opportunities include post-sun, post-shave and depilation aftercare, daily redness care, compromised barriers, and sensitive skin care. Comfort is part of formulation strategy.<\/p>\n

Image: soothing care after sun exposure and UV stress.<\/p>\n

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16 \u00b7 Healthy Aging: Soothing and Skin Resilience<\/h2>\n

Inflammation, cellular senescence, ECM damage, and skin aging are interconnected.<\/p>\n

Rhamnose research: in vitro and in vivo evidence relates to epidermal and dermal benefits, collagen IV, and procollagen I. Pageon et al., 2019, doi:10.1111\/ics.12523. [2]<\/p>\n

Rhamnose-rich oligosaccharide\/polysaccharide research: these materials can counter increases in the senescence marker SA-\u03b2-gal induced by advanced glycation end products (AGEs) in human skin fibroblasts. Ravelojaona et al., 2009, doi:10.1016\/j.archger.2007.12.004. [3]<\/p>\n

Patent WO2006037813A1 concerns saccharide compounds with repeated rhamnose-rich motifs and cosmetic anti-aging uses. [5]<\/p>\n

Attribution boundary: free rhamnose research must be distinguished from Biosaccharide Gum-2 product data. Free sugar results are not measurements of RhamnoCalm™.<\/p>\n

17 \u00b7 From Face to Scalp: Scalp Is Skin<\/h2>\n

The scalp and facial skin share keratinocytes, epidermal barriers, inflammatory responses, and sensory systems.<\/p>\n

Stressors include frequent washing, strong surfactants, coloring, bleaching, perming, oxidants, hot blow-drying, UV, pollution, dryness, friction, and styling residue.<\/p>\n

Common concerns include tightness, redness, dryness, irritation, sensitivity, and discomfort.<\/p>\n

Pathway: external stress \u2192 scalp keratinocyte stress \u2192 IL-1\u03b1\/PLA2\/PGE2 \u2192 discomfort and erythema. The positioning is based on glycobiological cell recognition. Patent WO2004078789A1 supports cosmetic applications on covering tissues including skin and scalp. [4]<\/p>\n

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18 \u00b7 Sensitive Scalp Care Solutions<\/h2>\n

Sensitive scalp shampoo: reduce discomfort during cleansing.<\/p>\n

Scalp soothing serum\/spray: for dry, tight, or reactive scalp.<\/p>\n

Post-color\/post-bleach care: for scalp after oxidative coloring or bleaching.<\/p>\n

Post-perm care: support comfort after chemical hair treatment.<\/p>\n

Oil-control plus comfort: for pollution, heat, and lifestyle stress.<\/p>\n

After-sun scalp care: for scalp after UV exposure.<\/p>\n

Men\u2019s scalp care: for areas prone to friction-related discomfort.<\/p>\n

Positioning includes scalp soothing, redness support, comfort after coloring or perming, stress-responsive care, and barrier-conscious hair care, without hair-growth or hair-loss prevention claims.<\/p>\n

19 \u00b7 Application Map: Skin and Hair Care<\/h2>\n

Sensitive skin: soothing serums, lotions, creams, and sprays.<\/p>\n

Potent anti-aging care: retinol, retinal, and acid products.<\/p>\n

Post-sun care: gels, lotions, and recovery sprays.<\/p>\n

Redness-prone skin: redness care serums, soothing masks, and barrier care.<\/p>\n

Healthy aging: anti-aging serums and creams.<\/p>\n

Baby\/child and gentle care: subject to product positioning and regulatory requirements.<\/p>\n

Acne-prone skin: oil-control serums and soothing support in acne-care formulas.<\/p>\n

After-shave\/depilation care: soothing products.<\/p>\n

From daily serums to post-color or post-perm scalp care, one glycan technology supports multiple comfort concepts.<\/p>\n

20 \u00b7 Formulation Guide: Technical Parameters<\/h2>\n

The full parameters appear below. They are based on the supplied technical information for a system equivalent in active strength to a 2.5% Biosaccharide Gum-2 reference solution.<\/p>\n

If the commercial product has a different active content, recalculate the recommended addition level accordingly. This fermentation-derived functional polysaccharide is positioned in the source for performance at low addition levels.<\/p>\n\n\n\n\n\n\n\n\n
Parameter<\/th>\nRecommendation<\/th>\n<\/tr>\n
Recommended addition level<\/td>\n3%\u20135% (for a system equivalent in active strength to a 2.5% Biosaccharide Gum-2 reference solution)<\/td>\n<\/tr>\n
Solubility<\/td>\nWater \u00b7 Propylene glycol \u00b7 Glycerin<\/td>\n<\/tr>\n
Recommended formulation pH<\/td>\nApproximately 4\u20138<\/td>\n<\/tr>\n
Thermal stability<\/td>\nUp to approximately 80 \u00b0C<\/td>\n<\/tr>\n
Processing<\/td>\nPreferably add during cooling below 45 \u00b0C. Reference information also permits addition to the aqueous phase at higher temperatures.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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21 \u00b7 Formulation Concepts: Complementary Combinations<\/h2>\n

RhamnoCalm™ + panthenol: soothing and hydration.<\/p>\n

+ allantoin: multi-pathway soothing.<\/p>\n

+ ectoin: protection against environmental stress.<\/p>\n

+ niacinamide: soothing and barrier care.<\/p>\n

+ Zinc PCA: oil control and comfort for acne-prone skin or scalp.<\/p>\n

+ ceramides: barrier resilience.<\/p>\n

+ retinoids: potent anti-aging care with a tolerable experience, with further opportunities in PAD\/salicylic acid systems.<\/p>\n

These are complementary formulation concepts. Unvalidated combinations do not support synergy claims.<\/p>\n

22 \u00b7 Why RhamnoCalm™: Cell Recognition and Multi-Target Soothing<\/h2>\n

Quantitative reference results: approximately 44% less visible redness at 2 hours (UV human model), 40% lower neutrophil adhesion (in vitro, 2% system), 28% lower induced IL-1\u03b1 (reconstructed epidermis, 2%), approximately 40% lower PLA2 activity (in vitro, 0.5%), and 46% more \u03b2-endorphin release (keratinocytes, 1%).<\/p>\n

Key positioning: rhamnose\u2013keratinocyte recognition, multi-target soothing involving IL-1\u03b1, adhesion, PLA2, and PGE2, \u03b2-endorphin-related neuro-comfort, rapid visible redness reduction, and modulation at several cascade nodes.<\/p>\n

Applications include sensitive or stressed skin, retinoid\/acid\/active formulations, skin and scalp care, healthy aging, and biotechnology-derived rhamnose-rich glycans.<\/p>\n

All figures are reference data for Biosaccharide Gum-2 systems. The corresponding chapters specify the models and conditions.<\/p>\n

23 \u00b7 Scientific References and Data Notes<\/h2>\n

1. Condaminet B. et al. Ultraviolet rays induced expression of lectins on the surface of a squamous carcinoma keratinocyte cell line. Experimental Cell Research. 1997;232(2):216\u2013224. DOI: 10.1006\/excr.1997.3518.<\/p>\n

2. Pageon H. et al. Potentially beneficial effects of rhamnose on skin ageing: an in vitro and in vivo study. International Journal of Cosmetic Science. 2019;41(3):213\u2013220. DOI: 10.1111\/ics.12523.<\/p>\n

3. Ravelojaona V., Robert A.M., Robert L. Expression of senescence-associated beta-galactosidase by human skin fibroblasts, effect of advanced glycation end-products and fucose or rhamnose-rich polysaccharides. Archives of Gerontology and Geriatrics. 2009;48(2):151\u2013154. DOI: 10.1016\/j.archger.2007.12.004.<\/p>\n

4. WO2004078789A1 \u2014 Novel agent for stimulating the release of beta-endorphins, cosmetic and\/or dermatological compositions containing same and uses thereof.<\/p>\n

5. WO2006037813A1 \u2014 Cosmetic composition comprising a saccharide compound having a repeated rhamnose-rich motif and its cosmetic use for skin anti-aging activity.<\/p>\n

Quantitative efficacy figures are reference data for rhamnose-rich Biosaccharide Gum-2 systems in the supplied technical information. Conditions are specified in each section. In vitro data do not represent clinical efficacy of finished products.<\/p>\n

PuriActives\u00ae and RhamnoCalm™ are trademarks of PuriPharm Co. Ltd. This material introduces cosmetic ingredients and makes no medicinal claims.<\/p>\n

www.puriactives.com<\/p>\n","protected":false},"excerpt":{"rendered":"

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