{"id":2121,"date":"2026-10-08T21:32:25","date_gmt":"2026-10-08T13:32:25","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=2121"},"modified":"2026-10-08T21:32:25","modified_gmt":"2026-10-08T13:32:25","slug":"puriactives-supra-allantoin","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=2121","title":{"rendered":"PuriActives\u00ae Supra-Allantoin"},"content":{"rendered":"

01 \u00b7 PuriActives\u00ae Supra-Allantoin<\/h2>\n

Beyond soothing: from skin barrier care to skin and scalp microbiome balance.<\/p>\n

PuriActives\u00ae Supramolecular Care System. PuriPharm Co. Ltd.<\/p>\n

02 \u00b7 Contents: From Molecule to Application<\/h2>\n

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03 \u00b7 Product Concept: From Soothing to Integrated Care<\/h2>\n

PuriActives\u00ae Supra-Allantoin combines Zinc PCA, Allantoin, Xyloglucan, and Alpha-Glucan Oligosaccharide. The presentation describes an integrated supramolecular care system in which four components cooperate within a hydrophilic network to address sebum management, soothing and recovery, flexible film formation, and microbiome balance across skin, scalp, and hair care.<\/p>\n

Purify: Zinc PCA for sebum and scalp environment management.<\/p>\n

Soothe: Allantoin for soothing and recovery.<\/p>\n

Protect: Xyloglucan for a flexible film and barrier interface.<\/p>\n

Balance: Alpha-Glucan Oligosaccharide for microbiome balance.<\/p>\n

One active system addresses oiliness, irritation, barrier stress, and microbial balance in sensitive oily skin and scalp.<\/p>\n

Source: PuriPharm public supramolecular product platform, puriactives.com (platform narrative).<\/p>\n

Source link from the presentation: https:\/\/www.puriactives.com\/en\/?p=1281<\/p>\n

04 \u00b7 Supra-Architecture: Four Components, One Integrated System<\/h2>\n

Zinc PCA (INCI: Zinc PCA): sebum balance, freshness, and scalp environment management. Functional Zn\u00b2\u207a ions and the skin-compatible PCA carrier form a small functional node.<\/p>\n

Allantoin (INCI: Allantoin): soothing, recovery, and support for stressed skin. This polar ureide molecule forms the soothing and recovery core.<\/p>\n

Xyloglucan (INCI: Xyloglucan): flexible film formation, a biomimetic interface, and support for skin cell recovery. A hydroxyl-rich polysaccharide backbone creates a flexible hydrophilic network.<\/p>\n

Alpha-Glucan Oligosaccharide (INCI: Alpha-Glucan Oligosaccharide; \u03b1-GOS): prebiotic microbiome balance and barrier support. These short-chain sugars can be selectively utilized by skin commensals.<\/p>\n

Sources: Allantoin\u2014Ara\u00fajo et al. 2010; Xyloglucan\u2014Nie & Deters 2013; \u03b1-GOS\u2014Duan et al. 2021; Zinc PCA\u2014public international supplier technical information. Full references appear in the final section.<\/p>\n

Source link from the presentation: https:\/\/ajiaminoscience.eu\/personalcare\/produit\/ajidew-zn-100\/<\/p>\n

05 \u00b7 Supra-Architecture: Dynamic Multipoint Interactions<\/h2>\n

The presentation proposes a dynamic hydrophilic network in which Zn\u00b2\u207a\/Zinc PCA functional nodes interact with Allantoin polar sites and polysaccharide hydroxyl groups through coordination, hydrogen bonding, electrostatic interactions, and hydrophilic associations.<\/p>\n

Structural modules comprise Zinc PCA functional nodes, a hydroxyl-rich flexible Xyloglucan backbone, Allantoin carbonyl\/ureide polar sites, and an \u03b1-GOS short-chain sugar ecological module. The architecture integrates four care functions in one system.<\/p>\n

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06 \u00b7 Molecular Mechanisms: Four Complementary Functions<\/h2>\n

Zinc PCA: functional zinc ions and the skin-compatible PCA carrier support sebum and microbial environment management.<\/p>\n

Allantoin: a ureide molecule provides the soothing and recovery core.<\/p>\n

Xyloglucan: a dense hydroxyl-rich polysaccharide network creates a flexible hydrophilic interface.<\/p>\n

\u03b1-GOS: prebiotic sugars can be selectively utilized by skin commensals.<\/p>\n

Small molecules deliver activity, polysaccharides organize the interface, and prebiotic sugars extend care into the microbial ecosystem. A dynamic supramolecular network forms the center.<\/p>\n

Sources: Zinc PCA sebum, freshness, and dandruff-care applications\u2014public international supplier information; XG film formation\u2014Kochumalayil et al. 2010, DOI: 10.1039\/C0JM00367K.<\/p>\n

Source link from the presentation: https:\/\/ajiaminoscience.eu\/personalcare\/produit\/ajidew-zn-100\/<\/p>\n

\"\"<\/p>\n

07 \u00b7 From Cell Recovery to Barrier Homeostasis<\/h2>\n

Surface ecosystem (\u03b1-GOS\/Zinc PCA): an ingredient-level human \u03b1-GOS study reported improved Simpson index in the low-diversity group, with trends toward increased S. epidermidis and decreased S. aureus.<\/p>\n

Stratum corneum (\u03b1-GOS): patent ex vivo\/cellular experiments observed changes in the barrier-associated proteins filaggrin and involucrin (NL2037619A).<\/p>\n

Epidermis (Xyloglucan): in vitro work supports proliferation and migration of human keratinocytes and fibroblasts, involving pro-proliferative signaling (Nie & Deters 2013).<\/p>\n

Dermis\/recovery layer (Allantoin): an animal open-wound model suggested inflammatory modulation, fibroblast proliferation, and extracellular matrix (ECM) synthesis (Ara\u00fajo 2010; preclinical evidence).<\/p>\n

Repair the tissue interface, support the barrier, and rebalance the ecosystem. The layer diagram illustrates mechanisms and does not establish product delivery depth.<\/p>\n

Sources: Duan 2021, 10.5107\/sccj.55.176; NL2037619A; Nie & Deters 2013, 10.1155\/2013\/359756; Ara\u00fajo 2010, 10.1590\/S0102-86502010000500014.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1590\/S0102-86502010000500014<\/p>\n

\"\"<\/p>\n

08 \u00b7 Skin Benefits: Sensitive, Oily, and Barrier-Stressed Skin<\/h2>\n

Calm without heaviness. Balance without stripping. Protect beyond the surface.<\/p>\n

Soothing and recovery: Allantoin + Xyloglucan combine a soothing core with a biomimetic interface to support stressed skin recovery.<\/p>\n

Shine and sebum balance: Zinc PCA supports management of visible sebum and a fresh feel.<\/p>\n

Barrier and moisture environment: Xyloglucan + \u03b1-GOS combine flexible hydrophilic film formation and prebiotic support.<\/p>\n

Microbiome balance: \u03b1-GOS + Zinc PCA integrate prebiotic microbial management with sebum environment management.<\/p>\n

Applications: sensitive oily skin serums, post-procedure\/post-exfoliation care concepts, sebum-balancing soothing lotions, complementary care for acne-prone skin, and fresh-feeling men\u2019s care.<\/p>\n

Source: a case series of 11 participants using a Zinc PCA-containing facial cream reported improvement in all participants after 8 weeks (Piquero-Casals et al. 2020). This is evidence from a multi-ingredient formulation.<\/p>\n

Source link from the presentation: https:\/\/pubmed.ncbi.nlm.nih.gov\/32574015\/<\/p>\n

09 \u00b7 Scalp Is Skin: Extending Barrier and Microbiome Science<\/h2>\n

Oil balance, scalp comfort, the microbiome, and hair surface care.<\/p>\n

Zinc PCA: freshness and use in dandruff-care formulations. Allantoin: soothing and sensitive scalp care concepts. \u03b1-GOS: microbiome-friendly scalp care concepts. Xyloglucan: flexible film formation and deposition-interface concepts for hair care.<\/p>\n

Formats: sebum-balancing shampoos, scalp serums, complementary dandruff-care products, sensitive scalp cleansing and conditioning, oily-root sprays, and leave-on scalp care.<\/p>\n

Image: illustrative macro photography of scalp and hair roots.<\/p>\n

Source: a prospective cohort of 20 participants reported improvement with a salicylic acid\/piroctone olamine\/Zinc PCA scalp regimen (PMID 39778065, 2025). These results relate to a multi-ingredient regimen.<\/p>\n

Source link from the presentation: https:\/\/pubmed.ncbi.nlm.nih.gov\/39778065\/<\/p>\n

\"\"<\/p>\n

10 \u00b7 Evidence Architecture: Clarifying Evidence Strength<\/h2>\n

The presentation organizes its system narrative using human, ex vivo, cellular, materials, and patent evidence. The diagram lists, from top to bottom, the Supra-Allantoin system, human\/clinical evidence, ex vivo\/cellular evidence, preclinical\/materials evidence, and patent\/supplier data.<\/p>\n

Human\/clinical: facial flora research on \u03b1-GOS and multi-ingredient facial\/scalp formulations containing Zinc PCA.<\/p>\n

Ex vivo\/cellular: \u03b1-GOS-associated filaggrin\/involucrin findings and XG skin cell proliferation\/migration.<\/p>\n

Preclinical\/materials: Allantoin animal wound models and XG film properties.<\/p>\n

Patent\/supplier: allantoin\u2013metal complexes and public Zinc PCA technical data.<\/p>\n

Communication follows the evidence and its limits. Ingredient, combination-formulation, patent, and materials studies do not establish direct human efficacy of the complete Supra-Allantoin system. Details follow in the next three sections and references.<\/p>\n

Source link from the presentation: https:\/\/www.jstage.jst.go.jp\/article\/sccj\/55\/2\/55_176\/_article\/-char\/en<\/p>\n

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11 \u00b7 Human \u03b1-GOS Evidence: Two-Week Microbiome Observations<\/h2>\n

Study design: an \u03b1-GOS-containing gel was applied to the whole face twice daily for 2 weeks. Wet-swab sampling and DNA metagenomic analysis assessed facial flora.<\/p>\n

Result 1: microbial diversity improved in the group with a low initial Simpson Index (SI). C. acnes abundance moved toward a more appropriate level in that group.<\/p>\n

Result 2: the overall population showed trends toward increased S. epidermidis and decreased S. aureus.<\/p>\n

Prebiotic care supports ecological balance. This is ingredient-level human evidence for \u03b1-GOS, and trend findings retain the source wording.<\/p>\n

Source: Duan Z, Yokota M, Eda Y. The Effect of Alpha-Glucan Oligosaccharide on Facial Skin Flora. J Soc Cosmet Chem Jpn. 2021;55(2):176\u2013181. DOI: 10.5107\/sccj.55.176.<\/p>\n

Source link from the presentation: https:\/\/www.jstage.jst.go.jp\/article\/sccj\/55\/2\/55_176\/_article\/-char\/en<\/p>\n

12 \u00b7 Recovery Evidence: Allantoin and a Biomimetic Polysaccharide Interface<\/h2>\n

Allantoin (preclinical animal model): histological findings in the open-wound model of Ara\u00fajo et al. 2010 involved inflammatory modulation, fibroblast proliferation, and ECM synthesis, providing a preclinical basis for soothing and recovery mechanisms.<\/p>\n

Xyloglucan (human skin cells in vitro): Nie & Deters 2013 reported that tamarind Xyloglucan promoted proliferation, cell-cycle progression, and migration, involving pro-proliferative signaling.<\/p>\n

Materials research by Kochumalayil et al. 2010 showed that water-cast XG films combined stiffness, strength, and ductile toughness, supporting a flexible biomimetic protective interface.<\/p>\n

A soothing core and a biomimetic interface supporting recovery.<\/p>\n

Sources: Ara\u00fajo, Acta Cir Bras. 2010;25(5):460\u2013466, 10.1590\/S0102-86502010000500014; Nie & Deters, 10.1155\/2013\/359756; Kochumalayil, 10.1039\/C0JM00367K.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1590\/S0102-86502010000500014<\/p>\n

13 \u00b7 Zinc PCA: Sebum and Scalp Balance<\/h2>\n

Public supplier information describes reduction of excess visible sebum, freshness of skin and hair, mild antimicrobial activity against yeasts and molds, and use in dandruff-care shampoo formulations.<\/p>\n

Patent support: technical data on 5\u03b1-reductase and MIC support the sebum-management rationale (CN107126379B).<\/p>\n

Clinical context from a combination cream: 11 patients with mild-to-moderate facial seborrheic dermatitis used a multi-ingredient Zinc PCA-containing cream for 8 weeks. All improved: 81.8% received an excellent rating and 18.1% a good rating, with 0 recorded adverse reactions. Percentages are retained exactly as supplied.<\/p>\n

Sources: public international supplier Zinc PCA information; Piquero-Casals J et al. J Drugs Dermatol. 2020;19(6), DOI: 10.36849\/JDD.2020.5121; CN107126379B.<\/p>\n

Source link from the presentation: https:\/\/ajiaminoscience.eu\/personalcare\/produit\/ajidew-zn-100\/<\/p>\n

Source link from the presentation: https:\/\/patents.google.com\/patent\/CN107126379B\/en<\/p>\n

14 \u00b7 Formulation Guide: Multiple Skin & Scalp Formats<\/h2>\n

Five-point addition gradient: 0.5%, 1%, 2%, 3%, and 5%. Evaluate clarity, viscosity, pH, electrolyte stability, centrifugation\/thermal cycling, and performance. The presentation recommends 1\u20133%, with up to 5% for enhanced formulations.<\/p>\n

Processing: preferably add to the aqueous phase or at a later stage. Evaluate the effects of pH, strong chelators, anionic surfactants, and electrolytes on Zn\u00b2\u207a and the supramolecular network.<\/p>\n

Sources: NL2037619A (\u03b1-GOS barrier proteins and formulation-range context); JP6995791B2 (XG cleansing\/conditioning formats); WO2014027120A2 (XG hair deposition).<\/p>\n

Source link from the presentation: https:\/\/patents.google.com\/patent\/NL2037619A\/en<\/p>\n\n\n\n\n\n\n\n\n\n
Format<\/th>\nApplication<\/th>\n<\/tr>\n
Soothing sebum-balancing serum<\/td>\nDaily care for sensitive oily skin<\/td>\n<\/tr>\n
Gel cream \/ lotion<\/td>\nSebum balance, soothing, and moisturization<\/td>\n<\/tr>\n
Mask<\/td>\nIntensive soothing care<\/td>\n<\/tr>\n
Scalp serum<\/td>\nScalp barrier and microbiome<\/td>\n<\/tr>\n
Shampoo<\/td>\nFresh-feeling sebum-balancing cleansing system<\/td>\n<\/tr>\n
Scalp spray<\/td>\nLeave-on scalp care<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

15 \u00b7 Regulatory & Safety Readiness: Established Ingredient Foundations<\/h2>\n

China: the PuriPharm ingredient database records XYLOGLUCAN in the 2025 and 2021 Inventory of Existing Cosmetic Ingredients, with a highest historical leave-on use level of 1.989%.<\/p>\n

USA: the presentation cites 21 CFR \u00a7347.10 for Allantoin as an OTC skin protectant at 0.5\u20132%. Its history of topical use and CIR safety assessment provide an established foundation.<\/p>\n

International: public \u03b1-GOS supplier information addresses use in the EU, USA, China, and Japan and COSMOS-related natural-origin information.<\/p>\n

The presentation positions all four components as established cosmetic ingredients for global development. These regulatory\/database statements reproduce the supplied presentation and do not imply approval or certification of this complex or finished products. They have not been independently updated for this conversion.<\/p>\n

Sources: PuriPharm Xyloglucan database; 21 CFR \u00a7347.10; Becker et al. 2010, CIR Allantoin safety assessment; public international \u03b1-GOS supplier information.<\/p>\n

Source link from the presentation: https:\/\/www.puriactives.com\/db\/public\/index.php\/materials\/detail\/22408<\/p>\n

Source link from the presentation: https:\/\/www.ecfr.gov\/current\/title-21\/chapter-I\/subchapter-D\/part-347\/subpart-B\/section-347.10<\/p>\n

Source link from the presentation: https:\/\/www.solabia.com\/cosmetics\/product\/bioecolia\/<\/p>\n

16 \u00b7 Market Positioning: From Soothing to Integrated Balance<\/h2>\n

A supramolecular care system built around Allantoin.<\/p>\n

Traditional Allantoin solutions: a single soothing position, established recovery care with a limited mechanism narrative, and substantial similarity between offerings.<\/p>\n

Supra-Allantoin positioning: soothing\/recovery and sebum balance, flexible film formation and microbiome care, and dual skin\/scalp applications.<\/p>\n

Four-in-One architecture: an integrated four-component supramolecular system.<\/p>\n

Mechanism chain: a three-layer narrative from molecule to microbiome.<\/p>\n

Dual applications: one active story for skin and scalp care.<\/p>\n

Expandable evidence framework: literature, patents, human, cellular, and materials evidence.<\/p>\n

17 \u00b7 Application Markets: Formulations with Multiple Care Functions<\/h2>\n

Functional sensitive-skin brands: sensitive oily skin serums, soothing masks, and barrier care concepts.<\/p>\n

Oily\/acne-prone skin brands: sebum-balancing recovery lotions and complementary acne care products.<\/p>\n

Professional scalp care brands: oily scalp serums, sebum-balancing shampoos, complementary dandruff-care products, and leave-on scalp sprays.<\/p>\n

International ODM\/OEM innovation centers: platform development of multiple formats across skin and scalp formulation libraries.<\/p>\n

Target contexts: sensitive\/oily skin, barrier stress, and scalp imbalance. One active story spans facial, scalp, and hair-care innovation.<\/p>\n

Image: illustrative photography of a translucent serum texture.<\/p>\n

\"\"<\/p>\n

18 \u00b7 Communication System<\/h2>\n

Primary: Calm. Balance. Protect.<\/p>\n

Alternatives: Beyond Soothing. From Molecule to Microbiome. One Supra-System. Skin & Scalp in Balance. Four Components. One Intelligent Interface.<\/p>\n

19 \u00b7 Scientific Evidence Sources: Six Core Evidence Streams<\/h2>\n

Six evidence dimensions address the human microbiome, skin cells, recovery mechanisms, clinical contexts, supramolecular chemistry, and barrier proteins. Original slide references in the table are retained for evidence navigation.<\/p>\n\n\n\n\n\n\n\n\n\n
Evidence dimension<\/th>\nProfessional source<\/th>\nSupporting content<\/th>\n<\/tr>\n
\u2460 Human microbiome<\/td>\nDuan et al. 2021, J Soc Cosmet Chem Jpn. DOI: 10.5107\/sccj.55.176<\/td>\n\u03b1-GOS: human flora changes over 2 weeks (slide 11)<\/td>\n<\/tr>\n
\u2461 Skin cells<\/td>\nNie & Deters 2013. DOI: 10.1155\/2013\/359756<\/td>\nXyloglucan: human skin cell proliferation and migration (slide 12)<\/td>\n<\/tr>\n
\u2462 Recovery mechanisms<\/td>\nAra\u00fajo et al. 2010, Acta Cir Bras. DOI: 10.1590\/S0102-86502010000500014<\/td>\nAllantoin: inflammatory modulation \/ fibroblasts \/ ECM (slide 12)<\/td>\n<\/tr>\n
\u2463 Clinical use contexts<\/td>\nPiquero-Casals et al. 2020, J Drugs Dermatol. DOI: 10.36849\/JDD.2020.5121<\/td>\nZinc PCA-containing facial care: improvement over 8 weeks (slide 13)<\/td>\n<\/tr>\n
\u2464 Supramolecular chemistry<\/td>\nWO1995026194A1 (allantoin\u2013metal complexes)<\/td>\nPrecedent for allantoin\u2013zinc coordination structures (slide 5)<\/td>\n<\/tr>\n
\u2465 Barrier proteins<\/td>\nNL2037619A (filaggrin \/ involucrin ex vivo)<\/td>\n\u03b1-GOS: barrier-associated protein support (slide 7)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

20 \u00b7 Scientific References & Patents<\/h2>\n

The following retains the full journal, human study, patent, supplier, and platform references from the presentation. Source hyperlinks are retained from the presentation. No additional URLs have been invented.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1590\/S0102-86502010000500014<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1155\/2013\/359756<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1039\/C0JM00367K<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.10.078<\/p>\n

Source link from the presentation: https:\/\/www.jstage.jst.go.jp\/article\/sccj\/55\/2\/55_176\/_article\/-char\/en<\/p>\n

Source link from the presentation: https:\/\/pubmed.ncbi.nlm.nih.gov\/32574015\/<\/p>\n

Source link from the presentation: https:\/\/pubmed.ncbi.nlm.nih.gov\/39778065\/<\/p>\n

Source link from the presentation: https:\/\/www.cir-safety.org\/ingredient\/allantoin<\/p>\n

Source link from the presentation: https:\/\/patents.google.com\/patent\/WO1995026194A1\/en<\/p>\n

Source link from the presentation: https:\/\/patents.google.com\/patent\/NL2037619A\/en<\/p>\n

JOURNALS & HUMAN STUDIES<\/p>\n

Ara\u00fajo LU, Grabe-Guimar\u00e3es A, Mosqueira VCF, et al. Profile of wound healing process induced by allantoin. Acta Cir Bras. 2010;25(5):460\u2013466. DOI: 10.1590\/S0102-86502010000500014<\/p>\n

Nie W, Deters AM. Tamarind seed xyloglucans promote proliferation and migration of human skin cells. Dermatol Res Pract. 2013:359756. DOI: 10.1155\/2013\/359756<\/p>\n

Kochumalayil J, Sehaqui H, Zhou Q, Berglund LA. Tamarind seed xyloglucan \u2014 a thermostable high-performance biopolymer. J Mater Chem. 2010;20:4321\u20134327. DOI: 10.1039\/C0JM00367K<\/p>\n

Picone P, et al. Biocompatibility, hemocompatibility and antimicrobial properties of xyloglucan-based hydrogel film. Int J Biol Macromol. 2019;121:784\u2013795. DOI: 10.1016\/j.ijbiomac.2018.10.078<\/p>\n

Duan Z, Yokota M, Eda Y. The effect of alpha-glucan oligosaccharide on facial skin flora. J Soc Cosmet Chem Jpn. 2021;55(2):176\u2013181. DOI: 10.5107\/sccj.55.176<\/p>\n

Piquero-Casals J, et al. Non-steroidal topical therapy for facial seborrheic dermatitis. J Drugs Dermatol. 2020;19(6). DOI: 10.36849\/JDD.2020.5121 (combination-formulation context evidence)<\/p>\n

A cohort clinical study on topical salicylic acid \/ piroctone olamine \/ Zinc PCA regimens in scalp seborrheic dermatitis. J Cosmet Dermatol. 2025. PMID 39778065 (combination-formulation context evidence)<\/p>\n

Becker LC, et al. Final report of the safety assessment of allantoin and its related complexes. Int J Toxicol. 2010. DOI: 10.1177\/1091581810362805<\/p>\n

PATENTS<\/p>\n

WO1995026194A1\u3000Allantoin-metal complexes for skin and hair (1995)<\/p>\n

NL2037619A\u3000Active ingredients capable of increasing skin barrier-associated protein differentiation<\/p>\n

CN107126379B\u3000Oil-control acne-removing composition and application thereof<\/p>\n

WO2014027120A2\u3000Cosmetic and household care compositions (2014)<\/p>\n

JP6995791B2\u3000Xyloglucan-containing gel composition<\/p>\n

SUPPLIER & PLATFORM DATA<\/p>\n

Zinc PCA technical product information \u2014 public international supplier technical information<\/p>\n

Alpha-Glucan Oligosaccharide technical information \u2014 public international supplier technical information<\/p>\n

PuriActives\u00ae public supramolecular platform information \u2014 puriactives.com (platform narrative)<\/p>\n

XYLOGLUCAN Xyloglucan ingredient information \u2014 PuriPharm ingredient database\uff1b21 CFR \u00a7347.10<\/p>\n","protected":false},"excerpt":{"rendered":"

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