{"id":2197,"date":"2026-10-11T22:20:58","date_gmt":"2026-10-11T14:20:58","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=2197"},"modified":"2026-10-11T22:20:58","modified_gmt":"2026-10-11T14:20:58","slug":"puriactives-suprahda","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=2197","title":{"rendered":"PuriActives\u00ae SupraHDA™"},"content":{"rendered":"

01 \u00b7 PuriActives\u00ae SupraHDA™: Supramolecular Royal Jelly Lipid Care<\/h2>\n

Multicomponent supramolecular complex. Royal jelly lipid intelligence. Four-dimensional balance.<\/p>\n

Four complementary dimensions support skin and scalp homeostasis. Components: Zinc PCA, 10-HDAA, Xyloglucan, and Alpha-Glucan Oligosaccharide.<\/p>\n

PuriPharm Co. Ltd.<\/p>\n

02 \u00b7 From One Active to Four-Dimensional Homeostasis<\/h2>\n

Oily, fragile, and fluctuating skin can combine excess sebum, barrier instability, environmental stress, and microbiome imbalance. SupraHDA™ organizes four functional ingredients into a supramolecular system for sebum, barrier, interface, and microbiome management.<\/p>\n

Purify, Renew, Buffer, Balance: four components, four pathways, and three application areas\u2014skin, scalp, and hair. Designed for next-generation skin and scalp care. The presentation describes complementary design roles, which do not themselves establish measured product synergy.<\/p>\n

03 \u00b7 Next-Generation Sebum Care: Managing Homeostasis<\/h2>\n

01 Oily skin: move from degreasing toward oil\/water balance and freshness without dryness.<\/p>\n

02 Blemish-prone skin: support microbial diversity and balance.<\/p>\n

03 Aging care: extend collagen care to barrier homeostasis and oxidative-stress defense.<\/p>\n

04 Scalp skinification: apply skin-care science to sebum, microbes, the barrier, and comfort.<\/p>\n

Long-term stability, comfort, and microbial balance extend the goals of sebum care.<\/p>\n

04 \u00b7 Product Identity<\/h2>\n

Product: PuriActives\u00ae SupraHDA™. Chinese name: supramolecular royal jelly acid. Type: multicomponent supramolecular active complex.<\/p>\n

Positioning: oily, combination, fluctuating, barrier-fragile skin and scalp sebum imbalance care.<\/p>\n

Final INCI follows formal TDS\/SPEC. If Royal Jelly Extract (CAS 91081-56-0) is confirmed, include it fully in actual formulation order.<\/p>\n

Zinc PCA: sebum\/freshness and the stratum-corneum moisture environment.<\/p>\n

10-Hydroxydecanoic Acid (CAS 1679-53-4): a royal-jelly-lipid-inspired hydroxy fatty acid.<\/p>\n

Xyloglucan: a flexible hydrated polysaccharide network for interface buffering and dispersion.<\/p>\n

Alpha-Glucan Oligosaccharide: prebiotic microbiome care.<\/p>\n

05 \u00b7 Purify, Renew, Buffer, Balance<\/h2>\n

01 Purify\u2014Zinc PCA: sebum, freshness, and environmental management; PCA supports stratum-corneum hydration and zinc-related aging-care concepts.<\/p>\n

02 Renew\u201410-Hydroxydecanoic Acid (10-HDAA): epidermal renewal, NMF-related pathways, environmental antioxidant\/aging care, and skin\/scalp comfort.<\/p>\n

03 Buffer\u2014Xyloglucan: hydrated films, interface buffering, dispersion, sensory properties, and smoother\/flexible hair feel.<\/p>\n

04 Balance\u2014Alpha-Glucan Oligosaccharide: prebiotic ecology, diversity, and homeostasis, supporting scalp microbiome concepts.<\/p>\n

The presentation integrates these roles as supramolecular synergy.<\/p>\n

06 \u00b7 High-Value Actives Need Effective Formulation Design<\/h2>\n

Challenges: limited aqueous dispersion; crystallization\/cloudiness; compatibility between ions and polymers; uneven skin-interface distribution; sensory effects at high use levels; and lack of synergy from simple ingredient addition.<\/p>\n

Hydroxy fatty acids and combinations require systematic dispersion, compatibility, interface, and sensory design. SupraHDA™ uses ionic, hydrogen-bonding, hydrophobic, and polysaccharide-network interactions to organize actives and support molecular cooperation.<\/p>\n

07 \u00b7 Multiple Noncovalent Interactions Form a Dynamic Network<\/h2>\n

Zinc PCA supplies ionic\/polar sites. 10-Hydroxydecanoic Acid supplies hydroxyl\/carboxyl groups and a hydrophobic chain. Xyloglucan provides a hydroxyl-rich hydrated network. Alpha-Glucan Oligosaccharide provides oligosaccharide hydrogen bonding and microbiome functions.<\/p>\n

Hydrogen bonds dynamically associate hydroxyl\/polar groups. Ionic association links zinc with carboxyl\/hydroxyl groups reversibly. Hydrophobic interactions organize medium-length chains. The Xyloglucan network supports dispersion\/structure, while hydration maintains a moist interface.<\/p>\n

The design uses reversible, dynamic, cooperative molecular organization.<\/p>\n

08 \u00b7 Five Steps from Formulation to Interface Performance<\/h2>\n

01 Association: noncovalent interactions dynamically associate four components.<\/p>\n

02 Dispersion: polysaccharide networks support uniform aqueous dispersion.<\/p>\n

03 Compatibility: adapt to multiple formats and reduce precipitation\/cloudiness risk.<\/p>\n

04 Retention: hydrated films support interface residence and uniform contact.<\/p>\n

05 Performance: express Purify, Renew, Buffer, and Balance pathways.<\/p>\n

Design goals: easier formulation, uniform contact, better sensory properties, and multifunctionality.<\/p>\n

\"\"<\/p>\n

09 \u00b7 Zinc PCA: Sebum and Skin Environment Management<\/h2>\n

Zinc signal: supports sebum management, less shine\/stickiness, and control of unfavorable microbial conditions.<\/p>\n

PCA moisture logic: PCA is associated with natural moisturizing factors, supporting stratum-corneum softness\/moisture and less tightness after sebum removal.<\/p>\n

Photoaging support: cellular research reported reduced UVA-induced AP-1 activation\/MMP-1 production and supported collagen synthesis.<\/p>\n

The zinc\/PCA combination links freshness with moisture, barrier, and photoaging-care concepts. The source\u2019s priority wording does not establish historical novelty.<\/p>\n

Ingredient-level cellular evidence: Takino et al. Int J Cosmet Sci. 2012;34(1):23\u201328. DOI: 10.1111\/j.1468-2494.2011.00676.x.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1111\/j.1468-2494.2011.00676.x<\/p>\n

10 \u00b7 PCA and the Stratum-Corneum Moisture Environment<\/h2>\n

Pathway: filaggrin breakdown produces free amino acids and NMF components including PCA, supporting hygroscopicity and softness.<\/p>\n

Zinc PCA combines zinc-related care with PCA\u2019s hydration rationale. NMF is the stratum corneum\u2019s own moisture-retention system, and PCA is an important component. Sebum care can preserve hydration.<\/p>\n

Ingredient-level physiology: Clar EJ, Fourtanier A. Int J Cosmet Sci. 1981;3(3):101\u2013113. DOI: 10.1111\/j.1467-2494.1981.tb00275.x.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1111\/j.1467-2494.1981.tb00275.x<\/p>\n

\"\"<\/p>\n

11 \u00b7 Royal Jelly Lipids: Distinct Hydroxy Fatty Acids<\/h2>\n

10-Hydroxydecanoic Acid (CAS 1679-53-4): saturated \u03c9-hydroxy fatty acid and a core SupraHDA™ INCI; terminal hydroxyl, carboxylic acid, and medium-length hydrophobic chain. Product claims should rely on this molecule and direct finished-product data.<\/p>\n

10-Hydroxy-2-Decenoic Acid (10-H2DA \/ 10-HDA): representative unsaturated royal jelly fatty acid with more extensive published skin research and an amphiphilic structure. Its literature provides family background and mechanism directions.<\/p>\n

The molecules have related structures but are distinct. Shared amphiphilic features support biological and assembly concepts. 10-H2DA literature is not direct test data for 10-Hydroxydecanoic Acid or SupraHDA™.<\/p>\n

12 \u00b7 Epidermal Differentiation and Barrier Maturation<\/h2>\n

Path A: PPAR\u03b1, IVL\/LOR\/FLG\/TGM1, terminal keratinocyte differentiation, cornified-envelope formation, and barrier integrity.<\/p>\n

Path B: SPT\/GBA\/ACACA, epidermal lipid production, and intercellular lipid support.<\/p>\n

The concept concerns the skin\u2019s own barrier-building programs, epidermal renewal, and cornification.<\/p>\n

Royal jelly lipid in vitro mechanism research: Yuan et al. J Funct Foods. 2024;122:106505. DOI: 10.1016\/j.jff.2024.106505.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1016\/j.jff.2024.10650<\/p>\n

\"\"<\/p>\n

13 \u00b7 NMF Hydration: Supporting Endogenous Moisture Retention<\/h2>\n

3D human epidermis study of 10-H2DA at 10\/20\/40 \u03bcmol\/L. At 40 \u03bcmol\/L, total stratum-corneum free amino acids increased approximately 70%.<\/p>\n

FLG mRNA, filaggrin protein, and free amino acids increased. AQP3 did not show similarly significant changes.<\/p>\n

The proposed route promotes cornification and NMF formation rather than only external humectancy. The source\u2019s \u201cendogenous water creation\u201d phrase is presented here as endogenous moisture retention.<\/p>\n

These are 10-H2DA model data, not SupraHDA™ finished-product tests.<\/p>\n

Gu et al. Cosmetics. 2017;4(4):48. DOI: 10.3390\/cosmetics4040048.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.3390\/cosmetics4040048<\/p>\n

14 \u00b7 Published Human Hydration Study<\/h2>\n

10 healthy volunteers; UV-induced dry skin; a cream containing 0.01% of a synthetic 10-H2DA counterpart; hydration index assessed on days 7 and 21.<\/p>\n

Chart change from baseline: baseline 0.0%, day 7 +28.8%, day 21 +60.4%.<\/p>\n

The literature supports sustained-hydration potential in dry\/barrier-fragile skin formulations. This is royal jelly lipid literature on a 10-H2DA counterpart, not SupraHDA™ product data.<\/p>\n

Duplan et al. Eur J Dermatol. 2011;21(6):906\u2013915. DOI: 10.1684\/ejd.2011.1531.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1684\/ejd.2011.1531<\/p>\n

\"\"<\/p>\n

Published human hydration data for a 10-H2DA counterpart: change from baseline (%)<\/p>\n

15 \u00b7 Supporting Cellular Antioxidant Defense<\/h2>\n

Stress chain: UVB\/pollution, ROS, protein\/lipid\/DNA stress, and barrier fragility.<\/p>\n

10-H2DA research: increased NQO1 expression and detoxification\/antioxidant responses. Nrf2- and AhR-related signals may participate, with reduced UVB\/oxidant-induced cellular damage.<\/p>\n

The concept extends radical scavenging to endogenous environmental defense.<\/p>\n

Cellular 10-H2DA evidence: Okumura et al. Int J Mol Sci. 2021;22(23):12973. DOI: 10.3390\/ijms222312973.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.3390\/ijms222312973<\/p>\n

\"\"<\/p>\n

16 \u00b7 Two Research Pathways for Collagen Preservation<\/h2>\n

Zinc PCA pathway: UVA, AP-1, and MMP-1. Research reports inhibition of UVA-induced AP-1, reduced MMP-1, and supported collagen synthesis.<\/p>\n

Royal jelly lipid pathway: UVA, ROS, JNK\/p38 MAPK, and MMP-1\/3. 10-H2DA research reports reduced ROS\/MMP-1\/MMP-3, supported collagen production, and less cellular senescence.<\/p>\n

The design links oxidative-stress and collagen-degradation pathways to firmness, resilience, and youthful radiance concepts.<\/p>\n

Ingredient-level Zinc PCA and 10-H2DA literature: Takino 2012, DOI: 10.1111\/j.1468-2494.2011.00676.x; Zheng 2013;27(10):1269\u20131277, DOI: 10.1111\/j.1468-3083.2012.04707.x.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1111\/j.1468-2494.2011.00676.x<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04707.x<\/p>\n

\"\"<\/p>\n

17 \u00b7 Microbiome and Biofilm Research<\/h2>\n

In vitro Staphylococcus aureus study with sub-inhibitory 10-H2DA: MIC 2.25 mg\/mL; biofilm quantity decreased 41.9\u201372.9%; biofilm cellular metabolic activity decreased 73.6% at 1\/2 MIC.<\/p>\n

Other observations: less EPS formation, adhesion and aggregation, downregulated sarA\/agrA\/hla, and reduced hemolysis-related virulence.<\/p>\n

These findings inform refined ecological-care concepts for oily\/fluctuating skin and scalp, without establishing direct product efficacy.<\/p>\n

Gao K et al. Molecules. 2022;27(5):1485. DOI: 10.3390\/molecules27051485.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.3390\/molecules27051485<\/p>\n

18 \u00b7 Alpha-Glucan Oligosaccharide: Selective Balance<\/h2>\n

Ingredient-level human study: an \u03b1-glucan oligosaccharide gel, whole-face application twice daily for 2 weeks, and metagenomic\/DNA sequence analysis.<\/p>\n

Results: improved Simpson Index in initially low-diversity participants; trends toward more S. epidermidis and less S. aureus; C. acnes moving toward a more suitable proportion; support for balance\/diversity.<\/p>\n

Prebiotic care offers selective nutrition for beneficial microbes and supports ecology rather than sterile skin. Face\/body\/scalp care concepts extend from these ingredient-level findings.<\/p>\n

Duan et al. J Soc Cosmet Chem Jpn. 2021;55(2):176\u2013181. DOI: 10.5107\/sccj.55.176.<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.5107\/sccj.55.176<\/p>\n

19 \u00b7 Xyloglucan: Active Delivery, Interface, and Comfort<\/h2>\n

Hydroxyl-rich polysaccharide chains support hydration, flexible films\/interface buffering, reduced water-loss\/tightness concepts, and improved skin\/scalp\/hair feel.<\/p>\n

Materials research: film-forming Xyloglucan hydrogels, cellular compatibility, maintenance of a moist microenvironment, and platforms for active carriage, protection, and controlled-release research.<\/p>\n

Three roles: active carriage, interface protection, and sensory comfort.<\/p>\n

Picone et al. Int J Biol Macromol. 2019;121:784\u2013795. DOI: 10.1016\/j.ijbiomac.2018.10.078; Infante et al. AAPS PharmSciTech. 2023;24(1):29. DOI: 10.1208\/s12249-022-02472-w (skin\/hair film-evaluation methods).<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.10.078<\/p>\n

Source link from the presentation: https:\/\/doi.org\/10.1208\/s12249-022-02472-w<\/p>\n

\"\"<\/p>\n

20 \u00b7 Four-Dimensional Integration<\/h2>\n

Purify: Zinc PCA for sebum and freshness. Renew: 10-Hydroxydecanoic Acid for barrier\/environmental-defense concepts. Buffer: Xyloglucan for hydrated films\/interface buffering. Balance: Alpha-Glucan Oligosaccharide for prebiotic homeostasis.<\/p>\n

Design goals: freshness without dryness, refined ecological management, renewal with barrier care, and performance with a comfortable formulation experience.<\/p>\n

\"\"<\/p>\n

21 \u00b7 Multiple Pathways for Complex Skin Needs<\/h2>\n

The table retains the presentation\u2019s proposed ingredient, mechanism, and consumer-value mapping. Contributions derive from ingredient\/literature research; the mapping does not substitute for direct product validation. In particular, 10-H2DA literature should not be treated as direct 10-Hydroxydecanoic Acid measurements.<\/p>\n\n\n\n\n\n\n\n\n\n
Skin need<\/th>\nKey components<\/th>\nPathway<\/th>\nConsumer value<\/th>\n<\/tr>\n
Visible shine<\/td>\nZinc PCA<\/td>\nSebum-related signals and a fresh environment<\/td>\nLasting freshness \/ less recurring shine<\/td>\n<\/tr>\n
Pores and blemishes<\/td>\nZinc PCA + 10-Hydroxydecanoic Acid<\/td>\nEnvironmental care \/ biofilm and blemish-trigger concepts<\/td>\nFiner-looking pores \/ more even texture<\/td>\n<\/tr>\n
Dryness and tightness<\/td>\nXyloglucan + 10-Hydroxydecanoic Acid<\/td>\nHydrated films \/ NMF formation concepts<\/td>\nSoftness, hydration, and comfort<\/td>\n<\/tr>\n
Fragile barrier<\/td>\n10-Hydroxydecanoic Acid + Xyloglucan<\/td>\nCornification, lipid synthesis, and buffering concepts<\/td>\nBarrier stability \/ tolerance<\/td>\n<\/tr>\n
Microbiome imbalance<\/td>\nAlpha-Glucan Oligosaccharide<\/td>\nSelective prebiotic support for beneficial microbes<\/td>\nMicrobial balance \/ stable condition<\/td>\n<\/tr>\n
Environmental aging<\/td>\nZinc PCA + 10-Hydroxydecanoic Acid<\/td>\nAntioxidant defense \/ less MMP-related degradation<\/td>\nFirmness, resilience, and photoaging-care concepts<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

22 \u00b7 Scalp Skinification: Homeostasis Science<\/h2>\n

Scalp sebum balance: freshness\/stability and less recurring oiliness. Scalp microbiome: prebiotic diversity\/homeostasis. Scalp barrier: cornification and lipid-environment concepts. Scalp comfort: polysaccharide films buffer interfaces and dryness\/tightness. Hair surface care: smoother feel, shine, and combability.<\/p>\n

Market language: scalp freshness\/balance, microbiome care, barrier care, comfort\/hydration, and light smooth hair.<\/p>\n

Claims remain cosmetic. No treatment claims for alopecia, medicinal hair growth, seborrheic dermatitis, fungal infections, or permanent dandruff elimination.<\/p>\n

The scalp is an extension of skin; the platform supports scalp and hair-care concepts.<\/p>\n

23 \u00b7 Eight Concept Product Directions<\/h2>\n

Facial: 1 Oil-Balance Serum for oily\/combination skin, Zinc PCA with Niacinamide\/Panthenol. 2 Microbiome Essence for fluctuating skin, \u03b1-glucan oligosaccharide with Ectoin\/Betaine. 3 Barrier Comfort Cream for dry\/fragile skin, 10-Hydroxydecanoic Acid\/Xyloglucan with Ceramides\/Cholesterol. 4 Pore Refining Gel for visible pores\/blemish-prone skin, gentle-acid alternative strategies and soothing ingredients.<\/p>\n

Scalp\/hair: 5 Scalp Balance Essence, sebum\/microbiome care with water-soluble polysaccharides\/peptides. 6 Fresh Scalp Shampoo, mild surfactants for comfort\/light roots. 7 Scalp Comfort Mask for dryness\/tightness, polysaccharides with Panthenol\/Phytosterols. 8 Lightweight Conditioner for smoothness without flatness, amino-acid conditioners.<\/p>\n

Suggested partners: Niacinamide, Panthenol, Betaine, Ectoin, Ceramides, Cholesterol, amino acids, mild surfactants, water-soluble polysaccharides, peptides, and phytosterols. Formulation experiments must confirm compatibility.<\/p>\n

24 \u00b7 Formulation Guidance for Multiple Formats<\/h2>\n

Predisperse in water or add later; avoid prolonged heat; assess electrolyte\/anionic\/cationic-polymer compatibility; test clarity and long-term stability across pH conditions; verify centrifugation, freeze\u2013thaw, thermal cycling, and light stability; calculate addition from actual active content. Exact specifications, use levels, and conditions follow formal TDS\/SPEC.<\/p>\n

Facial formats: serums, lotions, creams, hydrogels, sprays, masks. Cleansing\/body: facial cleanser, body lotion. Scalp\/hair: scalp serum, shampoo, conditioner, hair mask.<\/p>\n

Evaluate aqueous and emulsion systems across these applications.<\/p>\n

25 \u00b7 Product Data Roadmap<\/h2>\n

A Formulation\/assembly characterization: aqueous dispersion comparison, turbidity, centrifugation, thermal cycling, FTIR hydrogen-bond shifts, DSC, rheology, and particle size only where applicable.<\/p>\n

B In vitro efficacy: FLG, IVL, LOR, TGM1, NQO1, ROS, MMP-1, collagen-related indicators, inflammatory factors.<\/p>\n

C Microbiome: S. epidermidis, C. acnes, S. aureus, selective utilization, biofilms, 16S\/metagenomics.<\/p>\n

D Human skin: sebum, pores, shine, hydration, TEWL, redness, roughness, comfort.<\/p>\n

E Scalp\/hair: scalp sebum, root freshness, hydration, tightness\/itch, visible flakes, combing force, friction, shine, static control, and volume.<\/p>\n

Future completed tests will be labeled SupraHDA™ Product Data, clearly separate from ingredient\/literature evidence. Build the finished-product evidence chain progressively from A to E.<\/p>\n

26 \u00b7 Conclusion: Modern Royal Jelly Lipid Care<\/h2>\n

Purify: sebum clarity. Renew: barrier renewal. Buffer: interface protection. Balance: microbiome balance. Skin + Scalp: dual application.<\/p>\n

SupraHDA™ combines royal jelly lipid science, zinc functions, polysaccharide interfaces, and prebiotic concepts into a forward-looking homeostasis-care platform.<\/p>\n

Royal jelly lipid intelligence. Four-dimensional balance.<\/p>\n

27 \u00b7 References and Related Patents<\/h2>\n

The references, publication numbers, years, and technical directions supplied in the presentation are retained below. Patents support technical routes\/application contexts and are not SupraHDA™ finished-product efficacy data.<\/p>\n

1. Takino Y et al. Int J Cosmet Sci. 2012;34(1):23\u201328. DOI: 10.1111\/j.1468-2494.2011.00676.x<\/p>\n

2. Clar EJ, Fourtanier A. Int J Cosmet Sci. 1981;3(3):101\u2013113. DOI: 10.1111\/j.1467-2494.1981.tb00275.x<\/p>\n

3. Duplan H et al. Eur J Dermatol. 2011;21(6):906\u2013915. DOI: 10.1684\/ejd.2011.1531<\/p>\n

4. Zheng J et al. J Eur Acad Dermatol Venereol. 2013;27(10):1269\u20131277. DOI: 10.1111\/j.1468-3083.2012.04707.x<\/p>\n

5. Gu L et al. Cosmetics. 2017;4(4):48. DOI: 10.3390\/cosmetics4040048<\/p>\n

6. Okumura N et al. Int J Mol Sci. 2021;22(23):12973. DOI: 10.3390\/ijms222312973<\/p>\n

7. Gao K et al. Molecules. 2022;27(5):1485. DOI: 10.3390\/molecules27051485<\/p>\n

8. Yuan C-Y et al. J Funct Foods. 2024;122:106505. DOI: 10.1016\/j.jff.2024.106505<\/p>\n

9. Duan Z et al. J Soc Cosmet Chem Jpn. 2021;55(2):176\u2013181. DOI: 10.5107\/sccj.55.176<\/p>\n

10. Picone P et al. Int J Biol Macromol. 2019;121:784\u2013795. DOI: 10.1016\/j.ijbiomac.2018.10.078<\/p>\n

11. Infante VHP et al. AAPS PharmSciTech. 2023;24(1):29. DOI: 10.1208\/s12249-022-02472-w<\/p>\n

12. Gao C et al. Int J Pharm. 2026;701:127150. DOI: 10.1016\/j.ijpharm.2026.127150\u3000 (supramolecular formulation trend reference only)<\/p>\n

Related patents (publication number, year, and technical direction)<\/p>\n

US6514507B2\uff5c2002\uff5chydroxy-acid lipid use in skin care<\/p>\n

JPH10147514A\uff5c1998\uff5cpreparation and use of royal-jelly-derived hydroxydecanoic acid<\/p>\n

US20120237494A1\uff5c2012\uff5chydroxy fatty acids for skin barrier care<\/p>\n

GB2498543A\uff5c2013\uff5chydroxydecanoic acid compositions and skin applications<\/p>\n

US10993900B2\uff0fEP3041585A2\uff5csupramolecular carriers and active delivery<\/p>\n

US20230372218A1\uff5c2023\uff5cpolysaccharide\u2013active complexes and personal care<\/p>\n

Patents support technical routes and application contexts, not SupraHDA™ finished-product efficacy data.<\/p>\n","protected":false},"excerpt":{"rendered":"

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