{"id":2265,"date":"2026-10-13T21:49:42","date_gmt":"2026-10-13T13:49:42","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=2265"},"modified":"2026-10-13T21:49:42","modified_gmt":"2026-10-13T13:49:42","slug":"nanoactive-oryzanol","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=2265","title":{"rendered":"NanoActive™ Oryzanol"},"content":{"rendered":"

01 \u00b7 NanoActive™ Oryzanol: Oryzanol Nanoliposomes<\/h2>\n

Cosmetic active ingredient product introduction. INCI: ORYZANOL. Rice-derived antioxidant defense, reinvented by liposomal delivery.<\/p>\n

Powered by PURISOME\u00ae FlexVes™ Liposome Technology. PuriPharm Co. Ltd.<\/p>\n

\"\"<\/p>\n

02 \u00b7 From Rice-Bran Active to Nano-Delivered Antioxidant<\/h2>\n

\u03b3-Oryzanol is a group of phytosterol\/triterpene alcohol ferulate esters naturally found in rice bran oil. Sterol lipids provide lipid affinity, while ferulate groups provide radical-defense potential.<\/p>\n

Antioxidant: radicals\/lipid peroxidation. Photoaging care: light-induced oxidative stress. Aging care: collagen\/elastic-network concepts. Skin + Hair: skin, scalp, and hair.<\/p>\n

NanoActive™ uses lipid vesicles to improve practical cosmetic formulation design.<\/p>\n

03 \u00b7 \u03b3-Oryzanol Ingredient Science<\/h2>\n

A mixture of ferulate esters in the unsaponifiable fraction of rice bran oil. Representative components: Cycloartenyl Ferulate, 24-Methylene Cycloartanyl Ferulate, Campesteryl Ferulate, and Sitosteryl Ferulate.<\/p>\n

An ester bond links the phenolic antioxidant ferulic-acid moiety with a lipid-affine phytosterol\/triterpene-alcohol moiety.<\/p>\n

Sources: Lerma-Garc\u00eda et al. Food Chem. 2009;115:389\u2013404; Ramazani et al. Curr Pharm Des. 2021;27(19):2299\u20132316. DOI: 10.2174\/1381612826666201102101428.<\/p>\n

Source link: https:\/\/doi.org\/10.2174\/1381612826666201102101428<\/p>\n

References: Lerma-Garc\u00eda JM, et al. Food Chemistry. 2009;115:389\u2013404. \uff5c Ramazani E, et al. Curr Pharm Des. 2021;27(19):2299\u20132316. DOI: 10.2174\/1381612826666201102101428<\/p>\n

\"\"<\/p>\n

04 \u00b7 Plant Antioxidant and Skin Lipid Science<\/h2>\n

Image: rice bran, the natural source.<\/p>\n

01 Radical defense and oxidative-chain inhibition. 02 Lipid antioxidant activity in lipid-rich environments. 03 Ferulate UV-absorption\/antioxidant properties as a basis for photostress care. 04 Research on collagenase, elastase, hyaluronidase, and tyrosinase.<\/p>\n

\"\"<\/p>\n

05 \u00b7 Multiple Antioxidant and Aging-Care Pathways<\/h2>\n

The mechanism map includes lower ROS, lipid peroxidation, oxidative damage, collagenase, elastase, hyaluronidase, and tyrosinase.<\/p>\n

Concepts: antioxidant\/photoaging care, elasticity, hydration-related structures, even tone, soothing defense, and scalp\/hair antioxidants. These summarize in vitro\/model literature and do not establish finished-product clinical efficacy.<\/p>\n

\"\"<\/p>\n

06 \u00b7 Radical-Chain Management and Lipid Protection<\/h2>\n

Ferulate esters participate in radical scavenging and reduced radical-induced lipid peroxidation. Relevant lipid environments include stratum-corneum lipids, sebum, cellular membranes, hair surface lipids, and oxidizable formulation oils.<\/p>\n

Pathway: radical scavenging, lipid protection, and biological-structure protection.<\/p>\n

Juliano C, Cossu M, Alamanni MC, Piu L. Int J Pharm. 2005;299:146\u2013154. DOI: 10.1016\/j.ijpharm.2005.05.018.<\/p>\n

Source link: https:\/\/doi.org\/10.1016\/j.ijpharm.2005.05.018<\/p>\n

Juliano C, Cossu M, Alamanni MC, Piu L. Antioxidant activity of gamma-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils. Int J Pharm. 2005;299:146\u2013154. DOI: 10.1016\/j.ijpharm.2005.05.018<\/p>\n

\"\"<\/p>\n

07 \u00b7 Oxidative Stress Connects Exposure and Skin Aging<\/h2>\n

UV\/pollution\/ROS, oxidative stress, cellular damage, ECM degradation, and loss of elasticity\/roughness\/uneven tone form the schematic pathway.<\/p>\n

NanoActive™ Oryzanol uses antioxidant design for daily aging-care concepts. This does not replace sunscreen and provides no SPF\/PA claims.<\/p>\n

\"\"<\/p>\n

08 \u00b7 2026 Nanoencapsulated \u03b3-Oryzanol Research<\/h2>\n

Literature nanoemulsion, H\u2082O\u2082-induced NIH\/3T3 mouse fibroblast aging model: reduced intracellular ROS, supported survival\/migration, and inhibition of collagenase, elastase, hyaluronidase, and tyrosinase.<\/p>\n

Reported parameters: approximately 162 nm particle size, PDI 0.2, and zeta potential \u221251 mV. These are Yadav\u2019s independent nanoemulsion values, not NanoActive™ product parameters.<\/p>\n

Yadav P, Sankar J, Mora C, et al. Nanoencapsulated gamma-oryzanol enhances fibroblast proliferation, migration, and reduces oxidative stress in H\u2082O\u2082-induced cellular aging model. J Funct Foods. 2026;136:107130. DOI: 10.1016\/j.jff.2025.107130.<\/p>\n

Source link: https:\/\/doi.org\/10.1016\/j.jff.2025.107130<\/p>\n

Yadav P, Sankar J, Mora C, et al. Nanoencapsulated gamma-oryzanol enhances fibroblast proliferation, migration, and reduces oxidative stress in H\u2082O\u2082-induced cellular aging model. J Funct Foods. 2026;136:107130. DOI: 10.1016\/j.jff.2025.107130<\/p>\n

09 \u00b7 Protecting Collagen, Elastin, and Hyaluronic-Acid Networks<\/h2>\n

The dermal ECM schematic shows collagen, elastin, and hyaluronic acid. Oxidative stress and collagenase\/elastase\/hyaluronidase activity can contribute to network breakdown.<\/p>\n

Multi-enzyme defense extends the literature concept from ROS management to structural-network preservation.<\/p>\n

\"\"<\/p>\n

10 \u00b7 Fibroblast Vitality<\/h2>\n

Dermal fibroblasts maintain collagen, elastin, and ECM. Oxidative pressure can reduce vitality\/migration and accelerate structural decline.<\/p>\n

Yadav\u2019s 2026 nanoemulsion study reported ROS reduction, viability support, and migration in an oxidative model, informing cellular vitality, matrix defense, and resilience concepts.<\/p>\n

J Funct Foods. 2026;136:107130. DOI: 10.1016\/j.jff.2025.107130. Independent formulation evidence.<\/p>\n

Source link: https:\/\/doi.org\/10.1016\/j.jff.2025.107130<\/p>\n

Source: Yadav P, et al. J Funct Foods. 2026;136:107130 (literature nanoemulsion, not this product)\u3002DOI: 10.1016\/j.jff.2025.107130<\/p>\n

11 \u00b7 Tone and Brightening Research<\/h2>\n

2025 in vitro B16F10 mouse melanoma research: DPPH\/FRAP antioxidant activity, lower cellular ROS, mushroom tyrosinase inhibition, reduced cellular melanin, and melanogenesis-related inhibition.<\/p>\n

Concepts: antioxidant brightening, tyrosinase modulation, and even tone. In vitro potential does not establish clinical brightening or product efficacy.<\/p>\n

Emami SA, Hadipour E, Boozari M, et al. Comparison of Antioxidant and Anti-Melanogenic Activity of \u03b3-Oryzanol and Gallic Acid by Inhibiting Tyrosinase Activity in B16F10 Mouse Melanoma Cells. Food Sci Nutr. 2025;13:e70946. DOI: 10.1002\/fsn3.70946.<\/p>\n

Source link: https:\/\/doi.org\/10.1002\/fsn3.70946<\/p>\n

Emami SA, Hadipour E, Boozari M, et al. Comparison of Antioxidant and Anti-Melanogenic Activity of \u03b3-Oryzanol and Gallic Acid by Inhibiting Tyrosinase Activity in B16F10 Mouse Melanoma Cells. Food Sci Nutr. 2025;13:e70946. DOI: 10.1002\/fsn3.70946<\/p>\n

12 \u00b7 UV-Associated Antioxidant Defense<\/h2>\n

Schematic: UV exposure, ROS generation, lipid peroxidation, inflammatory stress, and ECM damage.<\/p>\n

Cosmetic language: helps defend against UV-induced oxidative stress; supports daily photostress protection; helps protect skin lipids from oxidative challenge.<\/p>\n

No SPF\/PA values, sunscreen replacement, or core regulatory claim of a natural sunscreen.<\/p>\n

\"\"<\/p>\n

13 \u00b7 Nanoethosome Delivery Evidence<\/h2>\n

2021 \u03b3-oryzanol nanoethosomes improved delivery\/cellular uptake, offered long-term storage protection, and showed protection in UVB-related models.<\/p>\n

The original mouse work involved UV-induced skin cancer; this article retains it as delivery\/photostress research, without disease-prevention\/treatment claims.<\/p>\n

Zeinali M, et al. Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes. Life Sci. 2021;283:119759. DOI: 10.1016\/j.lfs.2021.119759.<\/p>\n

Source link: https:\/\/doi.org\/10.1016\/j.lfs.2021.119759<\/p>\n

Zeinali M, et al. Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes. Life Sciences. 2021;283:119759. DOI: 10.1016\/j.lfs.2021.119759<\/p>\n

14 \u00b7 Formulation Challenges<\/h2>\n

Low water dispersibility; crystallization\/precipitation with system or temperature changes; reliance on oils, emulsions, or solubilizers; limited effective delivery of free active; and prolonged environmental exposure.<\/p>\n

Published approaches include solubilization, dispersion, emulsification, phospholipid complexes, and nanodelivery.<\/p>\n

Patent examples: JP6803732B2, Cosmetics containing \u03b3-oryzanol; WO2012110303A2, Aqueous cosmetic composition containing composite material particles and gamma-oryzanol; EP1957041B1, Oil-in-water emulsion and its use for delivery of functionality.<\/p>\n

Patent examples (publication number and title): JP6803732B2 \u00b7 Cosmetics containing \u03b3-oryzanol\uff1bWO2012110303A2 \u00b7 Aqueous cosmetic composition containing composite material particles and gamma-oryzanol\uff1bEP1957041B1 \u00b7 Oil-in-water emulsion and its use for delivery of functionality\u3002<\/p>\n

15 \u00b7 From Lipophilic Active to Formulation-Ready Nano Active<\/h2>\n

Oryzanol, PURISOME\u00ae FlexVes™, and NanoActive™ Oryzanol form the design pathway.<\/p>\n

Protection: a phospholipid microenvironment. Dispersion: an adapted form for cosmetics. Delivery: effective skin-surface contact potential. Flexibility: serums, lotions, creams, scalp, and hair products.<\/p>\n

The design changes incorporation and contact rather than merely adding free Oryzanol.<\/p>\n

\"\"<\/p>\n

16 \u00b7 Biomimetic Lipid Vesicle Architecture<\/h2>\n

The scientific schematic labels a hydrophilic aqueous core, phospholipid hydrophilic heads, and a hydrophobic bilayer domain. Highly lipophilic \u03b3-Oryzanol is proposed to associate preferentially with the bilayer rather than the inner aqueous core.<\/p>\n

Oryzanol, lipid-bilayer association, vesicular dispersion, and cosmetic delivery. The localization drawing is proposed architecture rather than a direct measurement.<\/p>\n

\"\"<\/p>\n

17 \u00b7 More Than 15 Years of Liposome Research<\/h2>\n

2009 topical \u03b3-oryzanol liposomes: phosphatidylcholine, cholesterol, CHAPS, and sodium taurocholate. Initial loading levels 3%, 5%, and 10%.<\/p>\n

Endpoints: size, zeta potential, entrapment, release, antioxidant activity, and cellular compatibility. Antioxidant activity remained after loading; some systems showed enhanced cellular antioxidant activity.<\/p>\n

Viriyaroj A, Ngawhirunpat T, Sukma M, et al. Physicochemical properties and antioxidant activity of gamma-oryzanol-loaded liposome formulations for topical use. Pharm Dev Technol. 2009;14(6):665\u2013671. DOI: 10.3109\/10837450902911937. Literature formulation, not product data.<\/p>\n

Source link: https:\/\/doi.org\/10.3109\/10837450902911937<\/p>\n

Viriyaroj A, Ngawhirunpat T, Sukma M, et al. Physicochemical properties and antioxidant activity of gamma-oryzanol-loaded liposome formulations for topical use. Pharm Dev Technol. 2009;14(6):665\u2013671. DOI: 10.3109\/10837450902911937\u3000\u2014literature formulation supporting NanoActive™ design, not product data.<\/p>\n

18 \u00b7 Research from Liposomes to Lipid Nanocarriers<\/h2>\n

2009 topical liposomes; 2009 solid lipid nanoparticles\/nanoemulsions (SLN\/NE); 2021 nanoethosomes; 2024 liposomal nanocarriers; 2026 cellular-aging nanoencapsulation.<\/p>\n

Independent teams use these strategies for stability, dispersion, and delivery, providing continuity for NanoActive™ design.<\/p>\n

Ruktanonchai U, et al. J Microencapsul. 2009;26(7):614\u2013626. DOI: 10.3109\/02652040802586571; Jasim AJ, et al. ACS Omega. 2024;9:3554\u20133564. DOI: 10.1021\/acsomega.3c07339. Other sources appear in their sections.<\/p>\n

Source link: https:\/\/doi.org\/10.3109\/02652040802586571<\/p>\n

Source link: https:\/\/doi.org\/10.1021\/acsomega.3c07339<\/p>\n

Ruktanonchai U, et al. J Microencapsul. 2009;26(7):614\u2013626. DOI: 10.3109\/02652040802586571 \uff5c Jasim AJ, et al. ACS Omega. 2024;9:3554\u20133564. DOI: 10.1021\/acsomega.3c07339 (see other research sections)<\/p>\n

\"\"<\/p>\n

19 \u00b7 Human Evidence from Composite Rice-Bran Vesicles<\/h2>\n

Composite system: Ferulic Acid + \u03b3-Oryzanol + Phytic Acid + Niosomes. 30 volunteers, 28 days.<\/p>\n

Endpoints: hydration, elasticity, thickness, roughness, and pigmentation. Gels\/creams containing the composite vesicles improved multiple aging-related indicators.<\/p>\n

All human effects cannot be attributed to \u03b3-oryzanol alone. The study supports composite rice-bran actives and vesicular delivery, not direct NanoActive™ efficacy.<\/p>\n

Manosroi A, Chutoprapat R, Abe M, Manosroi W, Manosroi J. Pharm Biol. 2012;50(2):208\u2013224. DOI: 10.3109\/13880209.2011.596206.<\/p>\n

Source link: https:\/\/doi.org\/10.3109\/13880209.2011.596206<\/p>\n

Manosroi A, Chutoprapat R, Abe M, Manosroi W, Manosroi J. Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds. Pharm Biol. 2012;50(2):208\u2013224. DOI: 10.3109\/13880209.2011.596206<\/p>\n

20 \u00b7 Antioxidant Defense and Inflammatory Stress<\/h2>\n

Non-skin models suggest effects on NF-\u03baB-associated inflammatory signaling. These provide research clues for oxidative\/inflammatory-stress care.<\/p>\n

Cosmetic concepts: comfort support, environmental defense, and reduced oxidative burden in sensitive\/tired\/stressed skin. No medicinal anti-inflammatory or disease-treatment claims.<\/p>\n

Ramazani E, Akaberi M, Emami SA, Tayarani-Najaran Z. Curr Pharm Des. 2021;27(19):2299\u20132316. DOI: 10.2174\/1381612826666201102101428.<\/p>\n

Source link: https:\/\/doi.org\/10.2174\/1381612826666201102101428<\/p>\n

Ramazani E, Akaberi M, Emami SA, Tayarani-Najaran Z. Biological and Pharmacological Effects of Gamma-oryzanol: An Updated Review of the Molecular Mechanisms. Curr Pharm Des. 2021;27(19):2299\u20132316. DOI: 10.2174\/1381612826666201102101428<\/p>\n

21 \u00b7 From Skin Lipids to Hair Lipids<\/h2>\n

Hair surface lipids face oxidative\/environmental stress. Concepts: scalp antioxidant defense; hair lipid protection; sun\/pollution\/heat-styling care; and phospholipid conditioning support.<\/p>\n

Patents: EP0945122A1, Haircare composition containing gamma-oryzanol and calcium salts; WO2012110303A2, skin\/hair photoprotection context.<\/p>\n

Claims stay within antioxidants, lipid care, and smoothness, excluding hair growth or hair-loss prevention.<\/p>\n

EP0945122A1 \u2014 Haircare composition containing gamma-oryzanol and calcium salts WO2012110303A2 \u2014 relates to skin and\/or hair photoprotection against ultraviolet radiation<\/p>\n

\"\"<\/p>\n

22 \u00b7 One Platform, Skin and Hair<\/h2>\n

Skin: antioxidants, photoaging-related stress, collagen\/elastic matrix, hyaluronic-acid-related structures, tone, and environmental comfort.<\/p>\n

Scalp\/hair: antioxidants, fiber oxidation protection, photostress, lipids, and conditioning. Hair-growth\/hair-loss claims are excluded.<\/p>\n

23 \u00b7 Modern Formulation Applications<\/h2>\n

Skin: antioxidant\/aging\/day-defense serums, photoaging-care lotion, recovery cream, brightening serum, urban protection, after-sun care, eye-aging care, and premium rice-bran concepts.<\/p>\n

Scalp: antioxidant serum, comfort care, post-sun care, and urban-pollution care. Hair: conditioner, mask, leave-on serum, oil\/emulsion, sun-exposure care, post-color\/perming care, and heat-styling care.<\/p>\n

The source cites commercial approximately 5% \u03b3-oryzanol emulsion ingredients for soap\/facial wash, lotion, shampoo, and conditioner as market context, not this product\u2019s active content or recommended use level.<\/p>\n

24 \u00b7 A Formulation-Friendly Oryzanol Design<\/h2>\n

Free active challenges: hydrophobicity, poor aqueous dispersion, crystallization, oil\/solubilizer dependence, complex processing, restricted formats, and delivery limitations.<\/p>\n

NanoActive™ design: lipid-vesicle organization, aqueous dispersion, handling convenience, a lipid-compatible microenvironment, serum\/emulsion use, and skin\/hair applications.<\/p>\n

This is qualitative dosage-form\/process comparison, without unverified fold-improvement claims. Actual performance requires formulation validation.<\/p>\n

25 \u00b7 Rice Antioxidant, Reinvented<\/h2>\n

Rice-derived science; radical\/lipid-peroxidation defense; ECM protection concepts; antioxidant tone support; skin\/scalp\/hair use; and PURISOME\u00ae FlexVes™ liposomal delivery.<\/p>\n

NanoActive™ Oryzanol brings a classic rice-bran antioxidant into precision lipid-delivery design.<\/p>\n","protected":false},"excerpt":{"rendered":"

01 \u00b7 NanoActive™ Oryzanol: Oryzanol Nanoliposome […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[25],"tags":[],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/2265"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2265"}],"version-history":[{"count":1,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/2265\/revisions"}],"predecessor-version":[{"id":2294,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/2265\/revisions\/2294"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2265"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2265"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}