{"id":2295,"date":"2026-10-14T14:59:31","date_gmt":"2026-10-14T06:59:31","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=2295"},"modified":"2026-10-14T14:59:31","modified_gmt":"2026-10-14T06:59:31","slug":"nanoactive-harpa","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=2295","title":{"rendered":"NanoActive™ Harpa"},"content":{"rendered":"

NanoActive™ HarpaLiposomal Devil\u2019s Claw Phytocomplex for Skin & Scalp Resilience<\/p>\n

BRAND & PRODUCT<\/p>\n

NanoActive™ Harpa \u00b7 Liposomal Harpagoside Botanical Complex<\/b><\/h2>\n

\"\"<\/p>\n

Liposomal Devil\u2019s Claw Phytocomplex for Skin & Scalp Resilience<\/p>\n

Powered by PURISOME\u00ae FlexVes™ Liposome Technology<\/p>\n

Soothe inflammatory signals, restore barrier resilience and revitalize the scalp<\/p>\n

PuriPharm Co., Ltd.<\/p>\n

PRODUCT OVERVIEW<\/p>\n

African desert botanical resilience meets modern nano-delivery<\/b><\/h2>\n

TRADE NAME<\/p>\n

NanoActive™ Harpa<\/p>\n

PRODUCT POSITIONING<\/p>\n

Liposomal harpagoside botanical complex<\/p>\n

INCI NAME<\/p>\n

HARPAGOPHYTUM PROCUMBENS ROOT EXTRACT<\/p>\n

BOTANICAL SOURCE<\/p>\n

Devil\u2019s claw root<\/p>\n

MARKER ACTIVES<\/p>\n

Harpagoside and other iridoid glycosides<\/p>\n

DELIVERY TECHNOLOGY<\/p>\n

PURISOME\u00ae FlexVes™ flexible vesicle liposome technology<\/p>\n

APPLICATIONS<\/p>\n

Skincare \u00b7 Scalp care \u00b7 Hair care<\/p>\n

KEY BENEFITS<\/p>\n

▪ Soothing and redness care<\/p>\n

▪ Barrier recovery<\/p>\n

▪ Reduced water loss<\/p>\n

▪ Inflamm-aging care<\/p>\n

▪ Scalp comfort<\/p>\n

▪ Root vitality<\/p>\n

PRODUCT VALUE<\/p>\n

\"\"<\/p>\n

Botanical actives<\/p>\n

FlexVes™ flexible liposomes<\/p>\n

Skin and scalp applications<\/p>\n

NanoActive™ Harpa<\/p>\n

MARKET INSIGHT<\/p>\n

Skin and scalp face shared inflammatory stress<\/b><\/h2>\n

DAILY STRESSORS<\/p>\n

▪ Air pollution<\/p>\n

▪ UV exposure and heat<\/p>\n

▪ Extreme temperature changes<\/p>\n

▪ Frequent cleansing<\/p>\n

▪ Surfactant irritation<\/p>\n

▪ Cosmetic procedures<\/p>\n

▪ Shaving<\/p>\n

▪ Hair coloring, bleaching and perming<\/p>\n

▪ Heat styling<\/p>\n

▪ Sleep and lifestyle stress<\/p>\n

\"\"<\/p>\n

BOTANICAL ORIGIN<\/p>\n

Devil\u2019s claw: resilience from the African desert<\/b><\/h2>\n

Harpagophytum procumbens grows mainly in arid southern Africa, including Namibia, Botswana, South Africa, Angola and parts of Zimbabwe.<\/p>\n

\u201cHarpago\u201d derives from the Latin word for \u201chook.\u201d The fruit\u2019s sharp hooks give the plant its common name, devil\u2019s claw.<\/p>\n

Adapted to extreme dryness: defensive secondary metabolites accumulate under desert heat and water stress.<\/p>\n

Secondary storage roots are the traditional plant material used and contain concentrated actives.<\/p>\n

Burgundy flowers and hooked fruits create a distinctive visual identity for the African desert botanical story.<\/p>\n

Traditional use and scientific interest connect southern African botanical practice with modern inflammation research.<\/p>\n

\"\"\"\"<\/p>\n

Namib Desert landscape; devil\u2019s claw flowers, hooked fruits, secondary roots and dried roots (reference images).<\/p>\n

Source: Zuplex Botanicals. Rosacalm Product Brochure. 2019 [5].<\/p>\n

PHYTOCHEMICAL PROFILE<\/p>\n

Beyond harpagoside: a multi-active botanical matrix<\/b><\/h2>\n

IRIDOID GLYCOSIDES<\/p>\n

    \n
  • Harpagoside (marker compound)<\/li>\n
  • Harpagide<\/li>\n
  • Procumbide<\/li>\n<\/ul>\n

    PHENOLIC GLYCOSIDES<\/p>\n

      \n
    • Acteoside \/ Verbascoside<\/li>\n
    • Isoacteoside<\/li>\n<\/ul>\n

      PHYTOSTEROLS<\/p>\n

        \n
      • \u03b2-Sitosterol<\/li>\n
      • TRITERPENES<\/li>\n
      • Oleanolic acid<\/li>\n
      • Ursolic acid<\/li>\n<\/ul>\n

        FLAVONOIDS<\/p>\n

          \n
        • Luteolin<\/li>\n
        • Kaempferol<\/li>\n<\/ul>\n

          AROMATIC ACIDS<\/p>\n

            \n
          • Caffeic acid<\/li>\n
          • Cinnamic acid<\/li>\n
          • Chlorogenic acid<\/li>\n<\/ul>\n

            Harpagoside is the principal marker compound. The full devil\u2019s claw root extract also contains multiple complementary actives.<\/p>\n

            Source: Zuplex Botanicals. Rosacalm Product Brochure. 2019 [5].<\/p>\n

            FORMULATION PHILOSOPHY<\/p>\n

            One marker compound, multiple complementary pathways<\/b><\/h2>\n

            SINGLE MARKER COMPOUND: HARPAGOSIDE<\/p>\n

            ▪ A defined active marker<\/p>\n

            ▪ A focus of mechanistic research<\/p>\n

            ▪ A clear anchor for scientific communication<\/p>\n

            FULL DEVIL\u2019S CLAW ROOT PHYTOCOMPLEX<\/p>\n

            ▪ Multiple iridoid glycosides<\/p>\n

            ▪ Complementary polyphenols and flavonoids<\/p>\n

            ▪ Additional triterpenes<\/p>\n

            ▪ Botanical activity across multiple targets<\/p>\n

            ▪ A broader rationale for soothing and repair<\/p>\n

            NanoActive™ Harpa delivers a botanical active network centered on harpagoside.<\/p>\n

            Source: Abdelouahab N, Heard C. J Nat Prod. 2008;71:746\u2013749. DOI: 10.1021\/np070204u [2].<\/p>\n

            THE DELIVERY CHALLENGE<\/p>\n

            Botanical actives need effective delivery<\/b><\/h2>\n

            Actives vary in polarity, making a single solvent system difficult to optimize.<\/p>\n

            Uneven partitioning between aqueous and oil phases affects formulation uniformity.<\/p>\n

            Suboptimal dispersion can limit active availability.<\/p>\n

            Limited skin or scalp contact time reduces surface residence.<\/p>\n

            Some actives are sensitive to light, oxidation and other environmental factors.<\/p>\n

            Conventional extracts offer limited technological differentiation for premium positioning.<\/p>\n

            Scalp actives may run off with liquid, further reducing contact efficiency.<\/p>\n

            PURISOME\u00ae FlexVes™ upgrades conventional devil\u2019s claw extract into a functional active with a modern delivery concept.<\/p>\n

            DELIVERY TECHNOLOGY<\/p>\n

            Flexible vesicles improve contact with target surfaces<\/b><\/h2>\n

            \"\"<\/p>\n

            TECHNOLOGICAL DIFFERENTIATION<\/p>\n

            From conventional botanical extract to NanoActive™ delivery<\/b><\/h2>\n\n\n\n\n\n\n\n\n\n\n
            Dimension<\/th>\nConventional devil\u2019s claw root extract<\/th>\nNanoActive™ Harpa<\/th>\n<\/tr>\n
            Botanical source<\/td>\nDevil\u2019s claw root<\/td>\nActive devil\u2019s claw root phytocomplex<\/td>\n<\/tr>\n
            Marker constituent<\/td>\nHarpagoside<\/td>\nMulti-component phytocomplex centered on harpagoside<\/td>\n<\/tr>\n
            Dispersion<\/td>\nConventional solution or dispersion<\/td>\nPhospholipid flexible vesicle delivery<\/td>\n<\/tr>\n
            Surface contact<\/td>\nPassive contact<\/td>\nDesigned to enhance contact with skin and scalp surfaces<\/td>\n<\/tr>\n
            Technology story<\/td>\nTraditional African botanical<\/td>\nAfrican botanical resilience + modern liposome technology<\/td>\n<\/tr>\n
            Applications<\/td>\nPrimarily skin soothing<\/td>\nSkin, scalp and hair care platform<\/td>\n<\/tr>\n
            Market positioning<\/td>\nNatural botanical extract<\/td>\nPremium botanical active with nano-delivery<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

            MECHANISM OVERVIEW<\/p>\n

            Soothing begins with upstream signaling<\/b><\/h2>\n

            \"\"<\/p>\n

            KEY MESSAGE<\/p>\n

            Modulation of upstream NF-\u03baB-related signals provides a mechanistic rationale for soothing, redness care and barrier repair with devil\u2019s claw root actives.<\/p>\n

            Source: Huang THW et al. J Ethnopharmacol. 2006;104:149\u2013155. DOI: 10.1016\/j.jep.2005.08.055 [1].<\/p>\n

            MECHANISM: NF-\u03baB<\/p>\n

            NF-\u03baB: a key regulator of inflammatory cascades<\/b><\/h2>\n

            NF-\u03baB links external stimuli with inflammatory mediator expression.<\/p>\n

            After stimulation, NF-\u03baB can activate and enter the nucleus, promoting inflammatory mediators associated with redness, heat sensations and barrier discomfort.<\/p>\n

            Studies of harpagoside report effects on NF-\u03baB activation and nuclear translocation, providing a molecular rationale for upstream inflammatory signal management.<\/p>\n

            The mechanistic evidence comes from published cellular and molecular studies and supports the product\u2019s soothing rationale [1].<\/p>\n

            \"\"<\/p>\n

            Source: Huang THW et al. J Ethnopharmacol. 2006;104:149\u2013155 [1].<\/p>\n

            MECHANISM: INFLAMMATORY MEDIATORS<\/p>\n

            Inflammatory mediator regulation at multiple levels<\/b><\/h2>\n

            iNOS<\/p>\n

            Inducible nitric oxide synthase<\/p>\n

            ▪ Involved in NO production during inflammation<\/p>\n

            ▪ Excess activity is associated with oxidative stress<\/p>\n

            ▪ May increase cellular stress<\/p>\n

            COX-2<\/p>\n

            Inducible cyclooxygenase<\/p>\n

            ▪ An important inducible enzyme in inflammation<\/p>\n

            ▪ Participates in prostaglandin production<\/p>\n

            ▪ Associated with redness, burning and discomfort<\/p>\n

            PGE2<\/p>\n

            Prostaglandin E2<\/p>\n

            ▪ Involved in local vasodilation and inflammatory signaling<\/p>\n

            ▪ May contribute to redness, swelling and barrier discomfort<\/p>\n

            NANOACTIVE™ HARPA: MECHANISTIC POSITIONING<\/p>\n

            NF-\u03baB \u2014 iNOS \u2014 COX-2 \u2014 PGE2 inflammatory signaling axis<\/p>\n

            Harpagoside and the full phytocomplex provide a rationale for soothing at multiple levels of this axis.<\/p>\n

            Sources: Huang THW et al., 2006 [1]; Abdelouahab N, Heard C., 2008 [2].<\/p>\n

            SKIN INTERFACE RESEARCH<\/p>\n

            From cellular signaling to topical skin applications<\/b><\/h2>\n

            ▪ Devil\u2019s claw root extract and its major glycosides have been studied in skin-related models [2].<\/p>\n

            ▪ Research includes epidermal COX-2 responses relevant to redness and discomfort signals.<\/p>\n

            ▪ Constituent ratios may influence overall effects; a single compound may not substitute for the full extract.<\/p>\n

            ▪ Skin models indicate complementary value from multiple constituents.<\/p>\n

            ▪ Transcutaneous and topical studies provide a mechanistic basis for cosmetic soothing applications [3].<\/p>\n

            \"\"<\/p>\n

            Skin model research connects molecular mechanisms with topical use, supporting the rationale for soothing and barrier repair.<\/p>\n

            Sources: Abdelouahab N, Heard C. J Nat Prod. 2008 [2]; Int J Pharm. 2009 (ex vivo skin model study) [3].<\/p>\n

            INFLAMM-AGING<\/p>\n

            Managing low-grade inflammatory stress for skin resilience<\/b><\/h2>\n

            Persistent low-grade inflammatory stress may affect skin cells, barrier function and the extracellular matrix. Inflamm-aging is therefore a concept used in premium anti-aging product development.<\/p>\n

            \"\"<\/p>\n

            APPLICATION TERRITORIES<\/p>\n

            ▪ Anti-aging for sensitive skin<\/p>\n

            ▪ Repair-focused anti-aging<\/p>\n

            ▪ Urban environmental care<\/p>\n

            ▪ Barrier-focused anti-aging<\/p>\n

            ▪ Soothing support alongside potent actives<\/p>\n

            ▪ Skin longevity and resilience concepts<\/p>\n

            Upstream signal management provides a scientific rationale for combining soothing with anti-aging product concepts.<\/p>\n

            Mechanistic sources: Huang THW et al., 2006 [1]; Abdelouahab N, Heard C., 2008 [2].<\/p>\n

            EFFICACY BENCHMARK: THIRD-PARTY DEVIL\u2019S CLAW ROOT EXTRACT DATA<\/p>\n

            Redness and water loss improvements over 24\u201348 hours<\/b><\/h2>\n

            TEST DESIGN<\/p>\n

            TEST LABORATORY\uff1aDermaconsult GmbH<\/p>\n

            PARTICIPANTS\uff1a20 participants, plus 1 reserve participant<\/p>\n

            SEX AND AGE\uff1a14 women and 6 men; 23\u201361 years<\/p>\n

            TEST AREA\uff1aInner forearm<\/p>\n

            ACTIVE CONCENTRATION\uff1a5%<\/p>\n

            ASSESSMENTS\uff1aSkin redness \u00b7 Transepidermal water loss \u00b7 Skin irritation patch test<\/p>\n

            INSTRUMENTS\uff1aCR-400 chroma meter \u00b7 Tewameter Triple TM 330 T<\/p>\n

            INSTRUMENTAL RESULTS<\/p>\n

            \"\"<\/p>\n\n\n\n\n\n
            Endpoint<\/th>\n24 hours<\/th>\n48 hours<\/th>\n<\/tr>\n
            Reduction in skin redness<\/td>\n9.1%<\/td>\n14.7%<\/td>\n<\/tr>\n
            Reduction in TEWL<\/td>\n16.7%<\/td>\n22.95%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

            ▪ Redness improvement observed at 24 hours<\/p>\n

            ▪ Greater improvement at 48 hours<\/p>\n

            ▪ Continued reduction in transepidermal water loss<\/p>\n

            ▪ Supports positioning for rapid soothing and barrier recovery<\/p>\n

            ▪ Relevant to products for sensitive, irritated or environmentally stressed skin<\/p>\n

            Note: These data come from a third-party human efficacy test of 5% conventional devil\u2019s claw root extract. They serve as botanical benchmarks for NanoActive™ Harpa product development and efficacy positioning.<\/p>\n

            Sources: Zuplex Botanicals. Rosacalm Product Brochure. 2019 [5]; Dermaconsult GmbH Test Summary [6].<\/p>\n

            SKINCARE PLATFORM<\/p>\n

            From rapid soothing to lasting barrier resilience<\/b><\/h2>\n

            CALM<\/p>\n

            ▪ Help reduce visible redness<\/p>\n

            ▪ Soothe tightness and discomfort<\/p>\n

            ▪ Help restore skin comfort<\/p>\n

            RESTORE<\/p>\n

            ▪ Support barrier recovery<\/p>\n

            ▪ Help reduce transepidermal water loss<\/p>\n

            ▪ Improve dryness, roughness and fragility<\/p>\n

            DEFEND<\/p>\n

            ▪ Help manage inflammatory signals associated with external stressors<\/p>\n

            ▪ Support care under pollution and climate stress<\/p>\n

            ▪ Provide soothing support in formulations with potent actives<\/p>\n

            REVITALIZE<\/p>\n

            ▪ Help restore a healthy, balanced appearance<\/p>\n

            ▪ Improve softness and moisturized feel<\/p>\n

            ▪ Support repair-focused anti-aging and skin resilience concepts<\/p>\n

            Rapid botanical soothing supports skin recovery and resilience.<\/p>\n

            SKINCARE APPLICATIONS<\/p>\n

            For repair-focused and sensitive-skin products<\/b><\/h2>\n

            01 Redness rescue serum<\/p>\n

            Rapid soothing care for environmental irritation, temperature changes, sleep loss and fragile skin.<\/p>\n

            02 Urban repair cream<\/p>\n

            For skin stressed by pollution, dryness and demanding lifestyles.<\/p>\n

            03 Soothing serum to complement potent actives<\/p>\n

            For concepts featuring retinol, retinal, acids or high-concentration niacinamide.<\/p>\n

            04 After-sun soothing lotion<\/p>\n

            Comfort care following UV and heat exposure.<\/p>\n

            05 Eye-area soothing serum<\/p>\n

            For the appearance of fatigue, dryness and puffiness.<\/p>\n

            06 Post-shave barrier repair lotion<\/p>\n

            For redness, tightness and discomfort after shaving.<\/p>\n

            OTHER APPLICATIONS<\/p>\n

            Soothing masks \u00b7 Body repair lotions \u00b7 Hand and foot care \u00b7 Cosmetic aftercare for tattoos \u00b7 Local repair gels<\/p>\n

            COMPLEMENTARY INGREDIENT CONCEPTS<\/p>\n

            Panthenol \u00b7 Ectoin \u00b7 \u03b2-Glucan \u00b7 Niacinamide \u00b7 Ceramides \u00b7 Bisabolol \u00b7 Allantoin \u00b7 Hyaluronic acid<\/p>\n

            SCALP SCIENCE<\/p>\n

            Scalpification brings barrier and soothing science to the scalp<\/b><\/h2>\n

            SCALP STRESSORS<\/p>\n

            ▪ Frequent shampooing<\/p>\n

            ▪ Surfactants<\/p>\n

            ▪ Sebum oxidation<\/p>\n

            ▪ Pollutant accumulation<\/p>\n

            ▪ UV and heat<\/p>\n

            ▪ Hair coloring, bleaching and perming<\/p>\n

            ▪ Blow-drying and heat styling<\/p>\n

            ▪ Scratching and mechanical friction<\/p>\n

            POTENTIAL IMPACT<\/p>\n

            ▪ Tightness and discomfort<\/p>\n

            ▪ Visible redness<\/p>\n

            ▪ Barrier imbalance<\/p>\n

            ▪ Dryness or sebum imbalance<\/p>\n

            ▪ Affected root environment<\/p>\n

            ▪ Reduced hair strength and healthy appearance<\/p>\n

            \"\"\"\"<\/p>\n

            Close-up scalp and hair-root images (reference images).<\/p>\n

            NanoActive™ Harpa extends sensitive-skin soothing science to scalp microenvironment care.<\/p>\n

            HAIR CARE DIRECTION: PATENT-SUPPORTED APPLICATION CONCEPTS<\/p>\n

            From botanical soothing to root vitality<\/b><\/h2>\n

            HENKEL AG & CO. KGAA<\/p>\n

            Patent WO2008031685A1<\/p>\n

            Root Extract of Harpagophytum for Stimulating Hair Growth<\/p>\n

            Published patent concerning devil\u2019s claw root extract for hair applications [4].<\/p>\n

            ▪ Devil\u2019s claw actives appear in hair strengthening and thickening concepts.<\/p>\n

            ▪ The patent addresses root vitality and hair-condition improvement.<\/p>\n

            ▪ Applications include shampoos, conditioners, scalp serums, sprays, lotions and scalp tonics.<\/p>\n

            ▪ Patent examples include formulations with devil\u2019s claw extract.<\/p>\n

            ▪ Studies involve dermal papilla cells and keratinocytes.<\/p>\n

            ▪ The patent discusses advantages of liposomal encapsulation in scalp and hair care products.<\/p>\n

            These patent-supported development directions provide technical and conceptual references for NanoActive™ Harpa scalp and hair care applications.<\/p>\n

            Source: Henkel AG & Co. KGaA. Patent WO2008031685A1 [4].<\/p>\n

            SCALP DELIVERY<\/p>\n

            Improving botanical contact with scalp and root surfaces<\/b><\/h2>\n

            CONVENTIONAL WATER-SOLUBLE BOTANICAL EXTRACT<\/p>\n

            ▪ Can run off with liquid<\/p>\n

            ▪ Limited surface residence<\/p>\n

            ▪ Potentially uneven distribution<\/p>\n

            ▪ Shorter scalp contact time<\/p>\n

            NanoActive™ Harpa<\/p>\n

            FLEXVES™ LIPOSOMAL DELIVERY<\/p>\n

            ▪ Delivery associated with phospholipid vesicles<\/p>\n

            ▪ Improved scalp surface distribution<\/p>\n

            ▪ Enhanced contact with follicular openings<\/p>\n

            ▪ Suitable for leave-on scalp serums and tonics<\/p>\n

            ▪ A modern technology concept for root care<\/p>\n

            ▪ Integration of soothing and root vitality concepts<\/p>\n

            Liposomal delivery is designed to support retention, uniform distribution and longer contact on the scalp.<\/p>\n

            SCALP & HAIR PLATFORM<\/p>\n

            Scalp comfort, root strength and revitalized hair<\/b><\/h2>\n

            SCALP COMFORT<\/p>\n

            ▪ Help soothe tightness and discomfort<\/p>\n

            ▪ Improve comfort in irritated scalps<\/p>\n

            ▪ Support scalp barrier balance<\/p>\n

            ROOT VITALITY<\/p>\n

            ▪ Support a healthy root microenvironment<\/p>\n

            ▪ Suitable for volumizing, strengthening and anti-hair-loss product concepts<\/p>\n

            ▪ Help improve the appearance of thinning and fragile hair<\/p>\n

            HAIR STRENGTH<\/p>\n

            ▪ Support damaged and fragile hair care<\/p>\n

            ▪ Help improve perceived strength and healthy shine<\/p>\n

            ▪ Suitable for care after coloring and perming<\/p>\n

            MARKET DIFFERENTIATION<\/p>\n

            African devil\u2019s claw botanical story \u00b7 Harpagoside mechanisms \u00b7 Skin and scalp applications \u00b7 Nano-liposome technology \u00b7 Soothing combined with root vitality<\/p>\n

            Scalp soothing is the starting point for a stronger, fuller-looking hair concept.<\/p>\n

            SCALP & HAIR PRODUCT CONCEPTS<\/p>\n

            From daily scalp balance to intensive root care<\/b><\/h2>\n

            01 Scalp soothing serum<\/p>\n

            For tightness, dryness and scalp discomfort.<\/p>\n

            02 Root vitality serum<\/p>\n

            For volume, strength and healthy-root concepts.<\/p>\n

            03 Sensitive-scalp shampoo<\/p>\n

            Combines gentle cleansing with scalp soothing.<\/p>\n

            04 Root strengthening conditioner<\/p>\n

            Supports smoothness and a stronger hair appearance.<\/p>\n

            05 Scalp repair serum after chemical treatments<\/p>\n

            Comfort care after coloring, bleaching or perming.<\/p>\n

            06 Volumizing leave-on spray<\/p>\n

            Lightweight, non-sticky daily root care.<\/p>\n

            COMPLEMENTARY INGREDIENT CONCEPTS<\/p>\n

            Caffeine \u00b7 Niacinamide \u00b7 Panthenol \u00b7 Zinc PCA \u00b7 Amino acids \u00b7 Peptides \u00b7 Ceramides \u00b7 Botanical antioxidants<\/p>\n

            NANOACTIVE™ HARPA<\/p>\n

            African desert resilience translated into beauty care<\/b><\/h2>\n

            SOOTHE INFLAMMATORY SIGNALS<\/p>\n

            A multi-component botanical system centered on harpagoside supports modern skin and scalp soothing concepts.<\/p>\n

            RESTORE BARRIER RESILIENCE<\/p>\n

            Third-party instrumental testing of the conventional extract supports positioning for redness care, reduced water loss and barrier recovery.<\/p>\n

            REVITALIZE THE SCALP<\/p>\n

            Patent-supported root-care directions and PURISOME\u00ae flexible vesicle delivery expand the possibilities for premium scalp and hair products.<\/p>\n

            NanoActive™ Harpa combines devil\u2019s claw botanical resilience with modern nano-liposome technology in an integrated concept for skin soothing, barrier recovery, scalp balance and root vitality.<\/p>\n

            \"\"<\/p>\n

            NanoActive™ Harpa \u00b7 Powered by PURISOME\u00ae FlexVes™ Liposome Technology<\/p>\n

            PURIPHARM CO., LTD.<\/p>\n

            REFERENCES<\/p>\n

            References and source materials<\/b><\/h2>\n

            [1] Huang THW, Tran VH, Duke RK, et al. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation. Journal of Ethnopharmacology. 2006;104(1\u20132):149\u2013155. DOI: 10.1016\/j.jep.2005.08.055<\/p>\n

            [2] Abdelouahab N, Heard C. Effect of the major glycosides of Harpagophytum procumbens on epidermal COX-2 in vitro. Journal of Natural Products. 2008;71(5):746\u2013749. DOI: 10.1021\/np070204u<\/p>\n

            [3] A Novel Ex Vivo Skin Model for the Assessment of the Potential Transcutaneous Anti-inflammatory Effect of Topically Applied Harpagophytum procumbens Extract. International Journal of Pharmaceutics. 2009.<\/p>\n

            [4] Henkel AG & Co. KGaA. Root Extract of Harpagophytum for Stimulating Hair Growth. Patent WO2008031685A1.<\/p>\n

            [5] Zuplex Botanicals. Rosacalm Product Brochure. 2019.<\/p>\n

            [6] Dermaconsult GmbH. Third-party instrumental evaluation of skin redness, transepidermal water loss and skin irritation, as summarized in the Rosacalm technical presentation.<\/p>\n

            [7] European Commission CosIng Database. HARPAGOPHYTUM PROCUMBENS ROOT EXTRACT.<\/p>\n","protected":false},"excerpt":{"rendered":"

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