{"id":2681,"date":"2026-10-22T22:35:36","date_gmt":"2026-10-22T14:35:36","guid":{"rendered":"http:\/\/www.puriactives.com\/en\/?p=2681"},"modified":"2026-10-22T22:35:36","modified_gmt":"2026-10-22T14:35:36","slug":"nanoactive-arteolea","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/en\/?p=2681","title":{"rendered":"NanoActive ArteOlea™"},"content":{"rendered":"

NanoActive ArteOlea™Artemisia annua Oil Nanoliposomes<\/h2>\n

Ingredient overview<\/p>\n

NanoActive ArteOlea™<\/h2>\n

\"\"<\/p>\n

PURIPHARM CO. LTD. \u00b7 Cosmetic Active Ingredients<\/p>\n

Artemisia annua Oil Nanoliposomes<\/p>\n

Water-compatible Artemisia.<\/p>\n

Broader botanical performance.<\/p>\n

INCI name: ARTEMISIA ANNUA EXTRACT<\/p>\n

A new botanical active platform that brings the rich phytochemistry of Artemisia annua into aqueous skin, scalp and hair-care formulations.<\/p>\n

Powered by PURISOME\u00ae FlexVes™ Liposome Technology<\/p>\n

Ingredient Innovation Profile \u00b7 2026<\/p>\n

Botanical platform<\/p>\n

A phytochemical resource with centuries of use<\/h2>\n

Artemisia annua L. (Asteraceae) has centuries of traditional medicinal use and is now among the most extensively studied medicinal plants. Surface glandular trichomes act as microscopic reservoirs, synthesizing and storing diverse lipophilic secondary metabolites.<\/p>\n

A living chemical factory.<\/b> Ten-cell glandular secretory trichomes cover the leaves and flowers, accumulating sesquiterpenes and volatile oils in subcuticular storage spaces.<\/p>\n

Chemical breadth.<\/b> Sesquiterpenes, flavonoids, phenolic acids, coumarins and volatile terpenes coexist in complementary proportions, creating a botanical platform beyond any single compound.<\/p>\n

Cosmetic relevance.<\/b> These classes relate to skin pathways involving oxidative stress, inflammatory signaling and barrier function.<\/p>\n

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Artemisia annua L., with finely divided, aromatic leaves. Aerial parts are richest in phytochemicals during flowering.<\/p>\n

Sesquiterpenes \u00b7 Flavonoids \u00b7 Phenolic acids \u00b7 Coumarins \u00b7 Volatile terpenes<\/p>\n

Ekiert H et al. Planta Med. 2021;87(8):584\u2013599. DOI: 10.1055\/a-1345-9528. PMID: 33482666. \u00b7 Duke MV, Paul RN. Int J Plant Sci. 1993;154(1):107\u2013118. DOI: 10.1086\/297094.<\/p>\n

Botanical platform<\/p>\n

Beyond artemisinin: a spectrum of phytochemical classes<\/h2>\n

The cosmetic value of Artemisia annua extends beyond one molecule. Its extracts combine complementary phytochemical classes that act on interconnected biological pathways.<\/p>\n\n\n\n\n\n
Phytochemical class<\/td>\nSesquiterpenes<\/td>\n<\/tr>\n
Representative constituents<\/td>\nArtemisinin \u00b7 Dihydroartemisinin \u00b7 Artemisinic acid<\/td>\n<\/tr>\n
Skin-related functions<\/td>\nInflammatory modulation; oxidative-stress signaling<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n
Phytochemical class<\/td>\nFlavonoids<\/td>\n<\/tr>\n
Representative constituents<\/td>\nQuercetin \u00b7 Luteolin \u00b7 Casticin \u00b7 Artemetin<\/td>\n<\/tr>\n
Skin-related functions<\/td>\nFree-radical scavenging; soothing; environmental defense<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n
Phytochemical class<\/td>\nPhenolic acids<\/td>\n<\/tr>\n
Representative constituents<\/td>\nChlorogenic acid \u00b7 Caffeic acid<\/td>\n<\/tr>\n
Skin-related functions<\/td>\nAntioxidant-network support; ROS modulation<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n
Phytochemical class<\/td>\nCoumarins<\/td>\n<\/tr>\n
Representative constituents<\/td>\nScopoletin \u00b7 Scopolin<\/td>\n<\/tr>\n
Skin-related functions<\/td>\nOxidative and skin-tone-related pathways<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n
Phytochemical class<\/td>\nVolatile terpenes<\/td>\n<\/tr>\n
Representative constituents<\/td>\nCamphor \u00b7 1,8-Cineole \u00b7 \u03b2-Caryophyllene<\/td>\n<\/tr>\n
Skin-related functions<\/td>\nSensory characteristics; skin comfort<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Ferreira JF et al. Molecules. 2010;15(5):3135\u20133170. DOI: 10.3390\/molecules15053135. PMID: 20657468. \u00b7 Bhakuni RS et al. Curr Sci. 2001;80(1):35\u201349.<\/p>\n

Formulation challenge<\/p>\n

Valuable chemistry with limited water compatibility<\/h2>\n

Many valuable Artemisia annua constituents are inherently lipophilic. Conventional aqueous formats struggle to accommodate them, creating a physical bottleneck between phytochemistry and cosmetic performance.<\/p>\n

Limited water solubility.<\/b> Lipophilic constituents precipitate in aqueous systems rather than dispersing uniformly.<\/p>\n

Crystallization risk.<\/b> Dissolved constituents may precipitate again during storage and temperature cycling.<\/p>\n

Restricted formats.<\/b> Clear toners, serums and gels are difficult to achieve, limiting conventional options to opaque emulsions.<\/p>\n

Uneven dispersion.<\/b> Poor distribution reduces contact between actives and the skin interface.<\/p>\n

Oxidative exposure.<\/b> Unprotected constituents degrade faster when exposed to oxygen and light.<\/p>\n

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Diagram text follows in the original order for mobile reading.<\/p>\n

Conventional constituents in an aqueous system<\/p>\n

Floating lipophilic constituents, undissolved<\/p>\n

Precipitation: active material lost from dispersion<\/p>\n

Schematic: lipophilic botanical constituents in water show poor dispersion, phase separation and reduced active availability.<\/p>\n

The formulation barrier is physical rather than biological: the chemistry has value, but the solvent environment is unsuitable.<\/p>\n

Delivery technology<\/p>\n

PURISOME\u00ae FlexVes™ Liposome Technology<\/h2>\n

Skin-compatible phospholipid bilayer vesicles bring lipophilic botanical actives into aqueous formulation formats.<\/p>\n

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Phospholipid bilayer vesicle: lipophilic actives reside in the membrane, with a water-compatible colloidal exterior.<\/p>\n

Encapsulation.<\/b> Lipophilic sesquiterpenes and flavonoids reside in the phospholipid bilayer, physically separated from the water in which they cannot dissolve.<\/p>\n

Water compatibility.<\/b> Vesicles disperse as stable colloids, converting oil-soluble phytochemistry into a form compatible with aqueous ingredients.<\/p>\n

Interfacial delivery.<\/b> Skin-compatible phospholipids support close contact with the stratum corneum and follicular openings, improving active presentation at biological interfaces.<\/p>\n

Protection.<\/b> The vesicular environment protects sensitive constituents from oxygen, light, aggregation and precipitation during processing and storage.<\/p>\n

Powered by PURISOME\u00ae Liposome Technology, PuriPharm Co. Ltd.\u2019s proprietary nanoliposomal delivery platform.<\/p>\n

Delivery technology<\/p>\n

From lipophilic potential to aqueous formulation flexibility<\/h2>\n

Lipophilic botanical constituents<\/b><\/p>\n

An extract rich in sesquiterpenes and flavonoids: biologically active, yet oil-affine and water-repellent.<\/p>\n

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PURISOME\u00ae encapsulation<\/b><\/p>\n

Actives are loaded into phospholipid bilayer vesicles, forming NanoActive ArteOlea™.<\/p>\n

Uniform aqueous dispersion<\/b><\/p>\n

A stable colloid carries the same active dose in each milliliter of formulation.<\/p>\n

Broader formulation options<\/b><\/p>\n

Toners, serums, gels, ampoules, masks and scalp tonics become accessible formulation categories.<\/p>\n

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Skin cross-section fluorescence images: carrier size influences distribution depth (a \u2192 c).<\/p>\n

Smaller carriers can travel farther.<\/p>\n

Reducing carrier size increases the effective concentration of particles at the skin surface and promotes distribution along skin pathways, providing a physical basis for delivery efficiency.<\/p>\n

NanoActive ArteOlea™ applies this principle in aqueous formulations.<\/p>\n

Fluorescence microscopy of skin cross-sections: PuriPharm Co. Ltd. Application Laboratory.<\/p>\n

Delivery technology<\/p>\n

Phytochemistry \u00d7 delivery science<\/h2>\n

What the plant provides<\/b><\/p>\n

Sesquiterpenes: stress-signaling modulation<\/p>\n

Flavonoids: antioxidant-network chemistry<\/p>\n

Phenolic acids: free-radical scavenging<\/p>\n

Coumarins: skin-tone pathway support<\/p>\n

Volatile terpenes: sensory comfort<\/p>\n

What the technology enables<\/b><\/p>\n

Water compatibility: aqueous and clear formats<\/p>\n

Colloidal dispersion: uniform active distribution<\/p>\n

Interfacial delivery: improved skin and scalp contact<\/p>\n

Encapsulation: support for formulation stability<\/p>\n

Format flexibility: from serums to scalp tonics<\/p>\n

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Figure labels: reduction in particle size; increase in lipid nanoparticle concentration.<\/p>\n

Nanocarrier mechanisms: small vesicles distribute uniformly across the stratum corneum; vesicle membranes support surface hydration. PuriPharm Co. Ltd. Application Laboratory.<\/p>\n

Efficacy platform<\/p>\n

One botanical platform, four skin-related pathways<\/h2>\n

NanoActive<\/p>\n

ArteOlea™<\/p>\n

Artemisia annua Oil Nanoliposomes<\/p>\n

Oxidative stress<\/b><\/p>\n

Free-radical scavenging by flavonoids and phenolic acids; modulation of ROS-driven signaling at the skin surface.<\/p>\n

Inflammatory signaling<\/b><\/p>\n

Reduced TSLP, IL-6 and IL-8; regulation of MAPK phosphorylation in stressed epidermis.<\/p>\n

Barrier function<\/b><\/p>\n

Restoration of filaggrin, loricrin and desmoglein-1 expression; normalization of epidermal structure.<\/p>\n

ECM \u00b7 Skin tone \u00b7 Follicles<\/b><\/p>\n

Type I collagen support in fibroblasts; melanin modulation in melanocytes; VEGF\/DKK1 signaling in dermal papilla cells.<\/p>\n

Pathway evidence: Tian Y et al. J Exp Pharmacol. 2025. PMID: 41116869. \u00b7 Zhao Y et al. Molecules. 2026. PMID: 41599277.<\/p>\n

Efficacy platform: soothing<\/p>\n

Calming inflammatory signals at their source<\/h2>\n

In stressed and sensitive skin, TSLP and downstream interleukins contribute to visible redness and discomfort. Artemisia annua chemistry acts on upstream signaling.<\/p>\n

Cytokine regulation.<\/b> In a 3D epidermal model of atopic inflammation, Artemisia annua extract (AAE) significantly reduced TSLP, IL-6 and IL-8, mediators linking barrier stress to visible irritation.<\/p>\n

Upstream signaling.<\/b> Phosphorylation of p38, JNK and ERK, key MAPK stress modules, decreased, indicating regulation at the signaling source.<\/p>\n

Supporting in vivo evidence.<\/b> Artemisia annua water extract alleviated DNCB-induced dermatitis in an animal model by restraining Th2-mediated responses, adding convergent evidence for a soothing platform.<\/p>\n

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Figure labels: control; AAE (%); protein expression (pg\/mL); TSLP; IL-1\u03b1, IL-6 and IL-8; GAPDH normalization. Original error bars, comparison brackets, ns and asterisks are retained.<\/p>\n

Cytokine expression (TSLP, IL-6, IL-8) after AAE treatment in an AD-like epidermal model.<\/p>\n

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Figure labels: gene number; P-value; p-p38 MAPK\/p38 MAPK ratio. Original GO\/KEGG pathway names and statistical marks are retained.<\/p>\n

AAE reduces MAPK phosphorylation (p38, JNK, ERK). Reproduced from Tian Y et al., 2025.<\/p>\n

Tian Y et al. J Exp Pharmacol. 2025;17:707\u2013720. DOI: 10.2147\/JEP.S550568. PMID: 41116869. \u00b7 Han X et al. J Ethnopharmacol. 2022;291:115160. PMID: 35245629.<\/p>\n

Efficacy platform: antioxidant defense<\/p>\n

Botanical antioxidant defense built on flavonoid chemistry<\/h2>\n

Artemisia annua flavonoids, including quercetin, luteolin and casticin, are documented free-radical scavengers that act alongside the plant\u2019s phenolic acids.<\/p>\n

A network of constituents.<\/b> Purified Artemisia annua flavonoids show strong antioxidant activity in biochemical assays. The overall flavonoid fraction outperforms isolated compounds, supporting a synergistic defense system.<\/p>\n

System-level evidence.<\/b> Transcriptomic analysis of an AD-like epidermal model shows enrichment of AAE-responsive genes in oxidative-stress, MAPK and inflammatory-response pathways, consistent with a botanical acting on multiple targets.<\/p>\n

Positioning.<\/b> Daily antioxidant defense for urban skin, supporting skin quality before oxidative stress becomes visible.<\/p>\n

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Figure labels: gene number and P-value. All original GO\/KEGG pathway names and groups are preserved in the figure.<\/p>\n

GO\/KEGG enrichment of AAE-responsive genes, with prominent oxidative-stress and MAPK-related pathways. Reproduced from Tian Y et al., 2025.<\/p>\n

Ferreira JF et al. Molecules. 2010;15(5):3135\u20133170. PMID: 20657468. \u00b7 Tian Y et al. J Exp Pharmacol. 2025;17:707\u2013720. PMID: 41116869.<\/p>\n

Efficacy platform: environmental defense<\/p>\n

Antioxidant biology for urban skin defense<\/h2>\n

Modern skin encounters continual oxidative challenges. NanoActive ArteOlea™ brings botanical defense chemistry into daily cosmetic care.<\/p>\n

Environmental stressors<\/b><\/p>\n

UV radiation \u00b7 Particulate matter \u00b7 Ozone<\/p>\n

ROS surge at the skin surface<\/b><\/p>\n

Lipid peroxidation \u00b7 Barrier stress \u00b7 Amplified inflammation<\/p>\n

Flavonoid + phenolic acid antioxidant network<\/b><\/p>\n

NanoActive ArteOlea™<\/p>\n

Visible outcomes<\/b><\/p>\n

\u00b7 Barrier integrity<\/p>\n

\u00b7 Even skin tone<\/p>\n

\u00b7 Lasting resilience<\/p>\n

\u00b7 Youthful skin quality<\/p>\n

Positioning areas<\/b><\/p>\n

Anti-pollution skin care:<\/b> daily defense against urban oxidative challenges<\/p>\n

Environmental-stress protection:<\/b> ROS management at the skin surface<\/p>\n

Prevention of premature aging:<\/b> early interruption of the stress\u2013aging cascade<\/p>\n

Skin resilience:<\/b> maintaining barrier quality under daily exposure<\/p>\n

Mechanistic basis: Ferreira JF et al. Molecules. 2010. PMID: 20657468. \u00b7 Tian Y et al. J Exp Pharmacol. 2025. PMID: 41116869.<\/p>\n

Efficacy platform: repair<\/p>\n

Soothing \u2192 protection \u2192 repair: supporting barrier resilience<\/h2>\n

Barrier damage makes inflammatory stress visible. Repair evidence positions AAE as an active for building skin resilience as well as soothing.<\/p>\n

Tissue-level repair.<\/b> In an AD-like 3D epidermal model, AAE restored normal epidermal morphology, reversing disrupted differentiation under inflammatory challenge.<\/p>\n

Barrier-gene recovery.<\/b> Expression of filaggrin (FLG), loricrin (LOR) and desmoglein-1 (DSG1) returned toward control levels, providing molecular evidence of structural repair.<\/p>\n

Cosmetic application.<\/b> Support recovery after environmental and inflammatory stress and reinforce daily barrier resilience in sensitive or stressed skin.<\/p>\n

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Figure labels: control; H&E; FLG; MC903 \/ IL-mix treatment conditions; \u03bcg\/mL; relative mRNA expression; NELL2, TSLP and IL-1\u03b1. Original labels and statistics are retained.<\/p>\n

3D epidermal model: restoration of H&E-stained morphology following AAE treatment.<\/p>\n

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Figure labels: control; AAE (%); H&E; FLG, LOR and DSG1; relative mRNA expression; HAS3 and NELL2; 50 \u03bcm scale bar. Original labels and statistics are retained.<\/p>\n

Barrier proteins FLG, LOR and DSG1 return toward control levels. Reproduced from Tian Y et al., 2025.<\/p>\n

Tian Y et al. J Exp Pharmacol. 2025;17:707\u2013720. DOI: 10.2147\/JEP.S550568. PMID: 41116869.<\/p>\n

Efficacy platform: healthy aging<\/p>\n

Protecting the extracellular matrix against stress-related aging<\/h2>\n

Oxidative and inflammatory stress accelerate collagen loss, contributing to visible loss of firmness. Artemisia annua sesquiterpene chemistry offers a line of defense.<\/p>\n

Type I collagen support.<\/b> Dihydroartemisinin (DHA), a characteristic Artemisia annua sesquiterpene derivative, increases type I collagen in human dermal fibroblasts in a dose-dependent manner, providing direct matrix-level evidence.<\/p>\n

A cell-compatible activity window.<\/b> Fibroblast viability is maintained across effective concentrations, a favorable cellular profile for leave-on cosmetic development.<\/p>\n

Cosmetic application.<\/b> Support skin density, visible firmness and a smooth appearance through matrix protection for healthy aging.<\/p>\n

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Figure labels: cell viability (%); average collagen I content (ng\/mL); control; DHA; DMSO; BC\/NC\/PC group abbreviations. Original concentrations, error bars and significance marks are retained.<\/p>\n

Fibroblast viability (A) and type I collagen content (B) following DHA treatment. Reproduced from Zhao Y et al., 2026.<\/p>\n

Zhao Y et al. Molecules. 2026;31(2):228. DOI: 10.3390\/molecules31020228. PMID: 41599277.<\/p>\n

Efficacy platform: skin tone<\/p>\n

Toward a more even skin tone<\/h2>\n

Pigmentation is closely intertwined with oxidative and inflammatory signaling, pathways relevant to Artemisia annua chemistry.<\/p>\n

Melanin modulation.<\/b> DHA reduces melanin content in melanocytes at tested concentrations while maintaining cell viability, indicating controlled modulation of melanogenesis within the cell-compatible range.<\/p>\n

Complementary coumarins.<\/b> Scopoletin and related Artemisia annua coumarins provide additional antioxidant support along oxidative pathways associated with skin tone.<\/p>\n

Positioning.<\/b> Brightening support and even skin tone within a broader antioxidant and soothing approach.<\/p>\n

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Figure labels: cell viability (%); melanin content (ng\/mL); control; PC-glabridin; DHA; \u03bcM; BC. Original dose labels and statistics are retained.<\/p>\n

Melanocyte viability (A) and melanin content (B) following DHA treatment. Reproduced from Zhao Y et al., 2026.<\/p>\n

Zhao Y et al. Molecules. 2026;31(2):228. PMID: 41599277. \u00b7 Ekiert H et al. Planta Med. 2021;87(8):584\u2013599. PMID: 33482666.<\/p>\n

Scalp and hair-care platform<\/p>\n

One botanical platform. Two beauty ecosystems.<\/h2>\n

Skin and scalp share inflammatory signaling, oxidative stress and barrier biology. NanoActive ArteOlea™ addresses both application areas.<\/p>\n

Skin<\/b><\/p>\n

Soothing and sensitive-skin support<\/p>\n

Antioxidant environmental defense<\/p>\n

Barrier repair and resilience<\/p>\n

Healthy aging and skin-tone support<\/p>\n

Shared biology<\/b><\/p>\n

Scalp and hair<\/b><\/p>\n

Scalp comfort and homeostasis<\/p>\n

Follicular oxidative-stress management<\/p>\n

A balanced scalp microenvironment<\/p>\n

Support for healthy hair<\/p>\n

Scalp and hair-care platform: comfort<\/p>\n

A calmer scalp creates a better environment for hair<\/h2>\n

Scalp sensitivity and seborrheic dermatitis involve inflammatory signaling, including pathways modulated by Artemisia annua chemistry in skin.<\/p>\n

Clinical direction.<\/b> A controlled clinical study reported significant anti-inflammatory efficacy in seborrheic dermatitis with a functional shampoo containing 0.063% artemether, an Artemisia annua sesquiterpene derivative.<\/p>\n

Mechanistic continuity.<\/b> The epidermal-model evidence involving TSLP, IL-6, IL-8 and MAPK regulation is relevant to inflammatory biology shared by the scalp.<\/p>\n

Cosmetic application.<\/b> Scalp comfort, reduced visible redness and daily support for sensitive scalp care, creating a calmer foundation for healthy hair.<\/p>\n

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Follicular openings provide a preferred entry route for nanocarriers into the scalp, bringing delivery to the target area.<\/p>\n

Pei Q et al. J Cosmet Dermatol. 2025;24(10):e70461. DOI: 10.1111\/jocd.70461. PMID: 40980936.<\/p>\n

Scalp and hair-care platform: oxidative stress<\/p>\n

Protecting the follicular microenvironment<\/h2>\n

Sebum oxidation, UV radiation and pollution converge at the follicular opening, where hair growth begins. Oxidative stress here affects scalp and hair quality.<\/p>\n

Antioxidant defense at the root.<\/b> The Artemisia annua flavonoid network brings documented free-radical-scavenging chemistry to the scalp surface, addressing oxidative pressure before it disrupts the follicular environment.<\/p>\n

Follicular delivery.<\/b> PURISOME\u00ae vesicles accumulate along follicular pathways. The nanocarrier mechanism supporting skin distribution also applies to scalp delivery.<\/p>\n

Outcome positioning.<\/b> Scalp resilience, homeostasis and a balanced microenvironment provide conditions for healthy hair.<\/p>\n

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Figure labels: nanoparticle; drug; SC = stratum corneum; E = epidermis; D = dermis; dermal\u2013epidermal junction; blood vessel.<\/p>\n

Nanocarrier distribution along follicular pathways, from the stratum corneum to the dermal\u2013epidermal junction (a \u2192 c).<\/p>\n

Antioxidant basis: Ferreira JF et al. Molecules. 2010. PMID: 20657468. \u00b7 Follicular targeting schematic: PuriPharm Co. Ltd. Application Laboratory.<\/p>\n

Scalp and hair-care platform: hair care<\/p>\n

From scalp biology to healthy hair<\/h2>\n

Dermal papilla signaling governs the hair cycle. VEGF supports follicular vitality, while DKK1 is associated with catagen signaling.<\/p>\n

Follicular signaling support.<\/b> In human dermal papilla cells, DHA increases VEGF expression and reduces DKK1, two mechanistically consistent effects on the follicular signaling environment.<\/p>\n

Aqueous scalp formats.<\/b> Water compatibility allows NanoActive ArteOlea™ to enter scalp tonics and leave-on formulations previously difficult for lipophilic botanical constituents, with potential for daily, non-greasy, low-residue formats.<\/p>\n

Concept areas.<\/b> Scalp tonics \u00b7 Leave-on scalp serums \u00b7 Anti-pollution hair care \u00b7 Antioxidant defense from scalp to hair shaft<\/p>\n

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Figure labels: cell viability (%); relative VEGF\/DKK1 mRNA expression; BC\/NC\/PC group abbreviations; DHA. All original concentrations, controls, error bars and significance marks are retained.<\/p>\n

Increased VEGF and decreased DKK1 in human dermal papilla cells. Reproduced from Zhao Y et al., 2026.<\/p>\n

Zhao Y et al. Molecules. 2026;31(2):228. DOI: 10.3390\/molecules31020228. PMID: 41599277.<\/p>\n

Formulation and applications<\/p>\n

One active, a full formulation landscape<\/h2>\n

Water compatibility turns a botanical extract into a platform ingredient compatible with the formats used by modern beauty brands.<\/p>\n

Toner:<\/b> a water-clear botanical revitalizing step<\/p>\n

Essence:<\/b> a lightweight daily antioxidant layer<\/p>\n

Serum:<\/b> concentrated soothing and defense<\/p>\n

Clear gel:<\/b> clarity without compromise<\/p>\n

Ampoule:<\/b> intensive post-stress repair<\/p>\n

Sheet mask:<\/b> soothing with extensive skin contact<\/p>\n

Light emulsion:<\/b> daily barrier support<\/p>\n

Scalp tonic:<\/b> targeted comfort at the roots<\/p>\n

Leave-on scalp serum:<\/b> a focus on follicular vitality<\/p>\n

Hair serum:<\/b> antioxidant defense from scalp to shaft<\/p>\n

The water-compatible form enables clear, low-viscosity systems across skin, scalp and hair-care categories.<\/p>\n

Formulation and applications<\/p>\n

Why water compatibility matters<\/h2>\n

01<\/b><\/p>\n

Easier incorporation.<\/b> Direct dispersion in the aqueous phase avoids heavy solubilizer workarounds or corrective heat-processing steps.<\/p>\n

02<\/b><\/p>\n

Uniform dispersion.<\/b> Colloidal vesicles distribute actives evenly through the bulk, supporting consistency across doses and bottles.<\/p>\n

03<\/b><\/p>\n

Greater interfacial availability.<\/b> Phospholipid carriers present lipophilic actives directly at skin and scalp surfaces.<\/p>\n

04<\/b><\/p>\n

Precipitation control.<\/b> Encapsulation prevents lipophilic constituents from crystallizing during shelf life and temperature cycling.<\/p>\n

05<\/b><\/p>\n

Broader format compatibility.<\/b> From clear toners to emulsions and scalp tonics, one active spans a full range of categories.<\/p>\n

06<\/b><\/p>\n

Formulation robustness.<\/b> Improved tolerance of processing, pH adjustment and storage stress throughout the product lifecycle.<\/p>\n

Technical value of the PURISOME\u00ae Liposome Technology platform, separate from and complementary to the extract\u2019s biological activity.<\/p>\n

Formulation and applications<\/p>\n

Five application concepts for the market<\/h2>\n

Soothing Defense Essence<\/b><\/p>\n

Daily essence \u00b7 Sensitive skin<\/p>\n

A daily soothing layer informed by TSLP and interleukin-modulation evidence, designed as lightweight care for irritation-prone, redness-prone skin.<\/p>\n

Urban Botanical Antioxidant Serum<\/b><\/p>\n

Defense serum \u00b7 Anti-pollution<\/p>\n

A flavonoid antioxidant network in a rapidly absorbing aqueous serum for daily defense against pollution-driven oxidative stress and its visible consequences.<\/p>\n

Post-Stress Repair Ampoule<\/b><\/p>\n

Intensive ampoule \u00b7 Barrier repair<\/p>\n

A concentrated repair concept informed by FLG\/LOR\/DSG1 recovery evidence, designed for skin after environmental or inflammatory stress.<\/p>\n

Scalp Comfort Tonic<\/b><\/p>\n

Scalp leave-on \u00b7 Daily comfort<\/p>\n

A water-light leave-on formula applying the platform\u2019s anti-inflammatory direction to sensitive, tight or visibly red scalps, for daily comfort at the roots.<\/p>\n

Botanical Defense Hair Serum<\/b><\/p>\n

Scalp and hair \u00b7 Scalp to shaft<\/p>\n

Follicular signaling support (VEGF\/DKK1) combined with antioxidant hair-shaft defense, linking scalp vitality with healthy hair in one serum.<\/p>\n

Concept directions for customer formulation development with NanoActive ArteOlea™.<\/p>\n

Summary<\/p>\n

NanoActive ArteOlea™ at a glance<\/h2>\n

Botanical chemistry<\/b><\/p>\n

The multiple phytochemical classes of Artemisia annua, including sesquiterpenes, flavonoids, phenolic acids and coumarins, map to skin-related biology.<\/p>\n

Water-compatible delivery<\/b><\/p>\n

PURISOME\u00ae FlexVes™ Liposome Technology converts lipophilic botanical constituents into colloidally stable, water-dispersible actives.<\/p>\n

Skin resilience<\/b><\/p>\n

Soothing, antioxidant defense, barrier repair, collagen support and skin-tone modulation provide evidence-informed directions for modern skin care.<\/p>\n

Scalp defense<\/b><\/p>\n

Scalp comfort, follicular oxidative-stress management and VEGF\/DKK1 signaling support form a second application platform.<\/p>\n\n\n\n\n\n\n
Trade name<\/td>\nNanoActive ArteOlea™ Artemisia annua Oil Nanoliposomes<\/td>\n<\/tr>\n
INCI name<\/td>\nARTEMISIA ANNUA EXTRACT<\/td>\n<\/tr>\n
Technology<\/td>\nPURISOME\u00ae FlexVes™ Liposome Technology<\/td>\n<\/tr>\n
Positioning<\/td>\nA water-compatible botanical active for skin, scalp and hair care<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

From lipophilic botanical actives to water-compatible performance.<\/p>\n

NanoActive ArteOlea™, developed and manufactured by PuriPharm Co. Ltd.<\/p>\n

References<\/p>\n

Scientific references<\/h2>\n

1. Tian Y et al. Artemisia annua Extract Ameliorates Atopic Dermatitis: Evidence from 3D Epidermal Model and Complementary in vitro Assays. J Exp Pharmacol. 2025;17:707\u2013720. DOI: 10.2147\/JEP.S550568. PMID: 41116869.<\/p>\n

2. Zhao Y et al. Potential Cosmetic Applications of Dihydroartemisinin. Molecules. 2026;31(2):228. DOI: 10.3390\/molecules31020228. PMID: 41599277.<\/p>\n

3. Pei Q et al. Anti-Inflammatory Efficacy of a Functional Shampoo Mixed With 0.063% Artemether for Seborrheic Dermatitis. J Cosmet Dermatol. 2025;24(10):e70461. DOI: 10.1111\/jocd.70461. PMID: 40980936.<\/p>\n

4. Han X et al. Artemisia annua water extract attenuates DNCB-induced atopic dermatitis by restraining Th2 cell-mediated responses. J Ethnopharmacol. 2022;291:115160. DOI: 10.1016\/j.jep.2022.115160. PMID: 35245629.<\/p>\n

5. Ekiert H et al. Artemisia annua \u2014 Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications. Planta Med. 2021;87(8):584\u2013599. DOI: 10.1055\/a-1345-9528. PMID: 33482666.<\/p>\n

6. Ferreira JF et al. Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin. Molecules. 2010;15(5):3135\u20133170. DOI: 10.3390\/molecules15053135. PMID: 20657468.<\/p>\n

7. Duke MV, Paul RN. Development and Fine Structure of the Glandular Trichomes of Artemisia annua L. Int J Plant Sci. 1993;154(1):107\u2013118. DOI: 10.1086\/297094.<\/p>\n

8. Bhakuni RS et al. Secondary metabolites of Artemisia annua and their biological activity. Curr Sci. 2001;80(1):35\u201349.<\/p>\n

Experimental figures reproduced from open-access publications, as cited on the relevant pages. Delivery-system images: PuriPharm Co. Ltd. Application Laboratory.<\/p>\n

Closing perspective<\/p>\n

Artemisia bioactivity \u00d7 water-compatible delivery \u00d7 modern cosmetic formulation<\/h2>\n

NanoActive ArteOlea™ translates the phytochemical potential of Artemisia annua into a water-compatible active platform for modern skin, scalp and hair-care formulations.<\/p>\n

PuriPharm Co. Ltd.<\/p>\n

Powered by PURISOME\u00ae FlexVes™ Liposome Technology<\/p>\n

NANOACTIVE ARTEOLEA™ Artemisia annua Oil Nanoliposomes<\/p>\n

INCI: ARTEMISIA ANNUA EXTRACT<\/p>\n","protected":false},"excerpt":{"rendered":"

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