INCI name:HYDROXYPHENYL PROPAMIDOBENZOIC ACID, PROPYLENE GLYCOL, BUTYLENE GLYCOL, PHOSPHOLIPIDS, TOCOPHERYL ACETATE, Dihydroavenanthramide D<\/p>\n
CAS: 697235-49-7.
\nTraits: colorless to yellow liquid
\nRecommended amount: 0.1-5%<\/p>\n
It is a kind of water-soluble liposome encapsulated active ingredients, and can be miscible with water in any proportion, so it is convenient and highly active. Clinical evidence shows that oat alkaloids are a powerful non-steroidal anti-inflammatory and antipruritic natural ingredient with a potency comparable to hydrocortisone, but without any side effects of steroid hormones. NanoCalmin have anti-inflammatory, anti-allergic, anti-irritant, rapid antipruritic, antihistamine, immune regulation, antifibrotic (anti-scarring), and anti-erythema effects. It can also effectively relieve itching, irritation, and redness of sensitive skin. PuriPharm can provide NanoCalmin powder with a high concentration of 99%.<\/p>\n
Overview<\/strong> About Allergic Reactions<\/strong> NanoCalmin’s Efficacy<\/strong> NanoCalmin’s Safety<\/strong> NanoCalmin’s Application<\/strong> 20% NanoCalmin aqueous solution<\/strong><\/p>\n NanoCalmin is lighter in color than the commercially available solution containing 5% Hydroxyphenyl Propamidobenzoic acid. <\/p>\n Formulation Guidelines<\/strong> Conclusion<\/strong> Good anti-irritant ingredients Effectively reduces itch […]<\/p>\n","protected":false},"author":3,"featured_media":354,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[17],"tags":[],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/350"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=350"}],"version-history":[{"count":4,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/350\/revisions"}],"predecessor-version":[{"id":992,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/350\/revisions\/992"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/media\/354"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=350"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nHydroxyphenyl Propamidobenzoic acid is derived from the active ingredient of oat (Avena Sativa), also known as dihydro oat acyl anthranilic acid, oat Avenanthramides or oat amide.
\nOat amide is an antioxidant substance unique in oat and has the highest content in the aleurone layer.
\nOat amide is used in bath product additives to relieve dry skin symptoms and skin itching.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/2-300x118.png\")
<\/p>\n
\nAllergy is the overreaction of the immune system to certain foreign substances that brought into contact with the body.
\nAllergic reactions can occur at any age.
\nThe most important factor affecting allergic reactions is heredity. Another major influencing factor is the environment.
\nInferior skin care products can also cause skin allergic reaction.<\/p>\n
\nHydroxyphenyl Propamidobenzoic acid and Tranilast are similar in structure .Tranilast has very powerful effects: anti-inflammatory, anti-allergic, anti-irritation, fast anti-itch, antihistamine, immunomodulation, anti-fibrosis (anti-scarring), anti-erythema.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/3\u526f\u672c-300x155.jpg\")
\nThe difference between Hydroxyphenyl Propamidobenzoic acid and anti-allergic drugs is that Hydroxyphenyl Propamidobenzoic acid inhibits allergic reaction as a therapeutic treatment, which can effectively prevent the occurrence and development of allergic reactions .
\nHydroxyphenyl Propamidobenzoic acid has less side effects than antihistamines and glucocorticoids, and has a significant therapeutic effect on anti-allergy .<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/5\u526f\u672c-254x300.jpg\")
\nTest to verify the effect of Hydroxyphenyl Propamidobenzoic acid against skin itching and blister erythema caused by histamine .
\nTest parameters:
\nItching: the number of times of tickling Skin.
\nerythema: relative initial erythema area .
\nHistamine hydrochloride (10mg\/ml) was added to the skin test site by a specific method.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/6-1024x425.png\")
\nApplication of histamine can cause severe itching, erythema, blisters.
\nHydroxyphenyl Propamidobenzoic acid can significantly alleviate skin abnormalities caused by histamine, such as itching, redness and blisters.
\nHydroxyphenyl Propamidobenzoic acid has a dose-dependent effect on skin itching and erythema relief.
\nHydroxyphenyl Propamidobenzoic acid has a mitigating effect on histamine-induced skin itching and erythema at very low concentrations.<\/p>\n
\nSome experts have studied the functional role of Hydroxyphenyl Propamidobenzoic acid in animals.
\nThe mice were fed in 2 groups. One is normal and the other added Hydroxyphenyl Propamidobenzoic acid at a dose of 0.1 g\/kg, the purpose of which is to see the ability of this substance to regulate the tissue oxidation and antioxidant balance in the mice.
\nIn addition, 50 days after feeding the mice, the two groups of mice were divided into the exercise group and the non-exercise group to study the effect of Hydroxyphenyl Propamidobenzoic acid on the oxidation induced by exercise in the internal organs of mice.
\nThe results showed that supplementation of Hydroxyphenyl Propamidobenzoic acid had no effect on the production of reactive oxygen species in most tissues except for the reduction of reactive oxygen species in the soleus muscle of mice, indicating that Hydroxyphenyl Propamidobenzoic acid does not affect cellular energy metabolism.
\nSupplementation with Hydroxyphenyl Propamidobenzoic acid improves superoxide dismutase activity in the thigh muscles, liver, and kidney, and increases glutathione peroxidase activity in the thigh muscles and heart. Exercise can increase reactive oxygen species in muscle and myocardium to accelerate the peroxidation of heart, liver and muscle. It has been found through experiments that oat amide can slow down the production of reactive oxygen species caused by muscle movement and reduce the phenomenon of fat peroxidation in the heart.
\nThis indicates that oat amide should be added as an effective antioxidant to the diet.<\/p>\n
\nHydroxyphenyl Propamidobenzoic acid has good efficacy but poor water solubility .
\nNanoCalmin is nano-coated so as to give Hydroxyphenyl Propamidobenzoic acid better stability, efficacy and safety, and at the same time is easy to use in formula .
\nNanoCalmin contains 5% Hydroxyphenyl Propamidobenzoic acid .
\nNanoCalmin utilizes a nano-delivery system (NDS) that not only solves the solubility problems and stability problems of biopolyphenols and dihydro oatAvenanthramides, but also greatly increases absorption efficiency and bioavailability.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/7-300x298.png\")
<\/p>\n
\nNanoCalmin is very soluble in water and does not affect the pH of the system .<\/p>\n
\nSuggested addition amount: 0.1-5%
\nHow to use: Add at 45 \u00b0 C (stable to heat)
\nSolubility: good water solubility
\nUse pH: 3-8
\nAttention: it should be preserved at low-temperature and dark place.
\nCompatibility: No incompatibility found at present.<\/p>\n
\nEfficient ingredients in anti-irritant and inflammation reduction.
\nEffectively reduces itching and redness .
\nAntihistamine, anti-oxidation.
\nEasy to formulate.
\nWide range of applications.
\nHhave a remarkable effect on skin care, hair care, body care and scalp care.<\/p>\n","protected":false},"excerpt":{"rendered":"