![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/35.png\")
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u21d2\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/36.png\")
<\/h1>\nHighly Efficient in Anti-Bacteria & Anti-Melanin
\nHighly efficient with very low dose of use
\nBorad activity to resist bacteria, fungi and pathogens.
\n0.00002% PIONIN can inhibit the growth of
\npropionibacterium acnes
\n0.00001% PIONIN can inhibit 83 % melanin formation<\/p>\n
Anit-acne: quickly and significantly reduce spots
\nReduce 50% of spots or rashes within 2 weeks<\/p>\n
Preservative activity: improve the efficacy of
\nparabens or completely replace them<\/p>\n
High security
\nCompliant with Japanese Quasi Drugsto be used in anti-acne products<\/p>\n
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u21d2\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0<\/h1>\nFast & deep effect on anti-acne & anti-freckle effect<\/strong> Bactericidal activity : PIONIN can be used as a preservative<\/strong> Highly efficient molecule in anti-bacteria & anti-melanin<\/strong> Inhibits bacteria and fungi with an extremely low dose of use ( In vitro test )<\/strong> Strong inhibition of melanin<\/strong> Highly safe and non-irritant<\/strong> Application : Aniti-acne, anti-freckle, whitening, cleansing<\/strong> Definition<\/strong> Formula Guidelines<\/strong><\/p>\n Technical indicators<\/strong><\/p>\n Storage<\/strong><\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" Highly Efficient in Anti-Bacteria & Anti-Melanin Hi […]<\/p>\n","protected":false},"author":3,"featured_media":403,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[17],"tags":[],"_links":{"self":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/380"}],"collection":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=380"}],"version-history":[{"count":2,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/380\/revisions"}],"predecessor-version":[{"id":395,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/posts\/380\/revisions\/395"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=\/wp\/v2\/media\/403"}],"wp:attachment":[{"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=380"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.puriactives.com\/en\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nIn Vitro Test : Strongly inhibit propionibacterium acnes.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/23.png\")
\nIn Vivo Tests: Effectively reduce propionibacterium acnes.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/24.png\")
\nNumber of propionibacterium acnes on the skin during skin care process.
\nClinical Test: Within two weeks, it reduced 50% spots
\nTesting program: Carry out test in 38 testees with acne problems.
\nMethod: Wash face 3 times every day with emulsion containing 0.001% of PIONIN and smears twice a week with cream containing 0.005% of PIONIN.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/25-1.png\")
<\/p>\n
\nThe PIONIN’s bactericidal ability allows it to be used as a preservative. In vitro test data shows that in term of anti-bacteria and anti-fungi of various kinds, PIONIN is more effective than paraben methyl ester. Therefore, just adding a small amount of paraben in the formulation containing PIONIN is enough to achieve an antibacterial effect.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/26.png\")
\nPIONIN can be used alone ( See the picture below, the number of E. coli contained in 0.002% PIONIN ).
\nPIONIN can compensate for the methylparaben ( Adding 0.002% PIONIN can lead to an increase of anti-E. Coli activity of 0.05% Methylparaben).
\nWhen mixed with polyols, PIONIN can completely replace parabens as a preservative.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/27.png\")
<\/p>\n
\nPIONIN similar to cyanine dyes. Even a single PIONIN molecule also has anti-bacterial activity, which is the reason why PIONIN is still efficient even with an extremely low dose:
\n-resistant to propionibacterium acnes
\nand inhibits melanin production
\n-improves the corrosion resistance
\nof finished products<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/28.png\")
\nBy causing collapse of cell membrane and cell wall and intracelluar degradation, PIONIN will damage the microorganisms.<\/p>\n
\nIn vitro test (see table below, agar plate dilution) proves that the extremely low dose of use of PIONIN can also inhibit a wide range of bacteria and fungi. The lowest concentration of PIONIN used to inhibit bacterial growth is called the Minimum Inhibitory Concentration (MIC).<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/29.png\")
<\/p>\n
\nPIONIN can prevent the formation of melanin. In vitro test indicates that:
\n– 0.000003% PIONIN can suppress 50% melanin formation
\n– 0.00001% PIONIN can suppress 83% melanin formation.
\nIn contrast, 0.07% kojic acid can inhibit 100% melanin formation.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/30.png\")
<\/p>\n
\nHuman body patch test ( human body, 0.2%, 48 hours ): negative
\nInitial skin irritation ( rabbit, 0.2%, 24 hours ): negative
\nSustained skin irritation ( rabbit, 0.01%, 90 day ): negative
\nEye irritation ( rabbit, 0.0007%, 24 hour ): negative
\nSkin sensitization ( Guinea pig, 0.2%, maximum test ): negative
\nPhototoxicity ( rabbit, 0.2%): negative
\nPhotosensitization ( Guinea Pig, 0.2%, Adjuvant-Strip Method ): negative
\nInduced gene mutation (10\u03bcg, Ames test, \u00b1S9 mix): negative
\nAcute Toxicity LD 50 ( mouse )\uff1a 325 mg\/kg<\/p>\n
\nAnti-acne, oily skin, anti-freckle
\nWhitening
\nCleaning formula, hand cream<\/p>\n
\nCommodity names : PIONIN
\nEnglish name : BIOXYNE
\nINCI name : Quaternary Ammonium Salt -73
\nChina INCI (2007): has been included
\nChina INCI (2010): has been included
\nCAS#: 15763-48-1
\nEINECS#: 239-852-5
\nRelated regulations : Compliant with Japanese Quasi-drugs for using in acne products.<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/31.png\")
<\/p>\n![\"\"](\"http:\/\/www.puriactives.com\/en\/wp-content\/uploads\/2018\/10\/32.png\")
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