{"id":2604,"date":"2019-08-30T18:19:10","date_gmt":"2019-08-30T09:19:10","guid":{"rendered":"http:\/\/www.puriactives.com\/jp\/?p=2604"},"modified":"2019-09-03T01:32:34","modified_gmt":"2019-09-02T16:32:34","slug":"%e3%83%8a%e3%83%8e%e3%82%b9%e3%83%a0%e3%83%bc%e3%82%b9nanosmooth","status":"publish","type":"post","link":"http:\/\/www.puriactives.com\/jp\/?p=2604","title":{"rendered":"\u30ca\u30ce\u30b9\u30e0\u30fc\u30b9NanoSmooth"},"content":{"rendered":"<p>\u8981\u7d04\uff1a\u30ca\u30ce\u30b9\u30e0\u30fc\u30b9\uff08NanoSmooth\uff09\u306f\u3001\u65b0\u3057\u3044\u30ca\u30ce\u4f1d\u9001\u6280\u8853\u306b\u3088\u3063\u3066\u690d\u7269\u7531\u6765\u306e\u69d8\u3005\u306a\u690d\u7269\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3084\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb\u30d7\u30ed\u30d1\u30df\u30c9\u5b89\u606f\u9999\u9178\u306a\u3069\u3001\u6d88\u708e 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http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image001-2-600x151.jpg 600w, http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image001-2.jpg 912w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 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P, SP) \u306a\u3069\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u3001Ca<sup>2+<\/sup>\u6d41\u5165\u3084K<sup> +<\/sup>\u6d41\u51fa\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001SP\u3068\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u907a\u4f1d\u5b50\u95a2\u9023\u30da\u30d7\u30c1\u30c9(calcitonin gene related peptide, CGRP) \u306e\u653e\u51fa\u306b\u3064\u306a\u304c\u308a\u3001\u4fb5\u5bb3\u53d7\u5bb9\u6027\u75bc\u75db\u3092\u5f15\u304d\u8d77\u3053\u3059[9]\u3002\u5929\u7136\u7523\u7269\u3092\u542b\u3080\u591a\u304f\u306eTRPV1\u30c1\u30e3\u30cd\u30eb\u8abf\u7bc0\u5264\u306f\u3001\u69d8\u3005\u306a\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u5bfe\u3057\u3066\u75db\u307f\u8efd\u6e1b\u52b9\u679c\u3092\u793a\u3057\u3001\u93ae\u75db\u85ac\u306e\u958b\u767a\u306b\u91cd\u8981\u306a\u6a19\u7684\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-2606\" src=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image004-300x204.gif\" alt=\"\" width=\"300\" height=\"204\" \/><\/p>\n<p style=\"text-align: center\">\u30ab\u30d7\u30b5\u30a4\u30b7\u30f3\u53d7\u5bb9\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020<\/p>\n<p>\u3053\u308c\u307e\u3067\u306b\u81ea\u7136\u754c\u304b\u3089\u767a\u898b\u3055\u308c\u305f\u3001TRP\u30c1\u30e3\u30cd\u30eb\u3092\u6a19\u7684\u3068\u3059\u308b\u5929\u7136\u8abf\u7bc0\u5264\u306f100\u7a2e\u4f59\u308a\u306b\u9054\u3057\u3001\u4e3b\u306b\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u3001\u30c6\u30eb\u30da\u30ce\u30a4\u30c9\u3001\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30da\u30d7\u30c1\u30c9\u3001\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306a\u3069\u306e\u6210\u5206\u3092\u542b\u307f\u300170\u7a2e\u4f59\u308a\u306e\u52d5\u690d\u7269\u306b\u95a2\u308f\u308b\u3002\u307b\u3068\u3093\u3069\u306e\u8abf\u7bc0\u5264\u306f\u3001TRP\u30c1\u30e3\u30cd\u30eb\u3092\u6d3b\u6027\u5316\u307e\u305f\u306f\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185Ca<sup>2+<\/sup>\u30ec\u30d9\u30eb\u3092\u4e0a\u3052\u305f\u308a\u4e0b\u3052\u305f\u308a\u3057\u3066\u3001\u795e\u7d4c\u7d42\u672b\u306e\u8131\u611f\u4f5c\u3001\u5185\u56e0\u6027\u7269\u8cea\u653e\u51fa\u306e\u8a98\u5c0e\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u4f53\u5185\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u3001\u93ae\u75db\u3001\u6297\u708e\u75c7\u3001\u795e\u7d4c\u7cfb\u4fdd\u8b77\u306a\u3069\u306e\u6d3b\u6027\u3092\u793a\u3059\u3002<\/p>\n<p>\u79d1\u5b66\u7684\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u3084\u4e94\u500d\u5b50\u62bd\u51fa\u7269\u306a\u3069\u306e\u690d\u7269\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306f\u6d88\u708e\u30fb\u93ae\u75db\u52b9\u679c\u306e\u3042\u308b\u5b89\u5168\u306aTRPV1\u62ee\u6297\u85ac\u3067\u3042\u308b\u3002\u65e5\u672c\u4eba\u79d1\u5b66\u8005Yoshihito Shimazu\u3089\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u5c40\u6240\u752810mM\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306e\u93ae\u75db\u52b9\u679c\u304c37mM(1%)\u30ea\u30c9\u30ab\u30a4\u30f3\u306b\u5339\u6575\u3059\u308b\uff08Brain Research Bulletin\uff0c<a href=\"\/dx.doi.org\/10.1016\/j.brainresbull.2016.06.001&amp;quot\">http:\/\/dx.doi.org\/10.1016\/j.brainresbull.2016.06.001<\/a>\uff09\u3002<\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-2607\" src=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image005-5-300x214.jpg\" alt=\"\" width=\"300\" height=\"214\" srcset=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image005-5-300x214.jpg 300w, http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image005-5-768x547.jpg 768w, http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image005-5-1024x729.jpg 1024w, http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image005-5-600x427.jpg 600w, http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image005-5.jpg 1269w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p style=\"text-align: center\"><strong>TRPV1\u3092\u6a19\u7684\u3068\u3059\u308b\u30ca\u30ce\u30b9\u30e0\u30fc\u30b9NanoSmooth\u306e\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb\u30d7\u30ed\u30d1\u30df\u30c9\u5b89\u606f\u9999\u9178\u306f\u3001\u30aa\u30fc\u30c8\uff08Avenasativa\uff09\u306e\u6d3b\u6027\u6210\u5206\u306b\u7531\u6765\u3057\u3001\u8fc5\u901f\u306a\u6297\u708e\u75c7\u30fb\u304b\u3086\u307f\u6b62\u3081\u6d3b\u6027\u3092\u6301\u3064\u3002\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u9ea6\u89d2\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u306f\u3001\u708e\u75c7\u306b\u76f4\u63a5\u95a2\u9023\u3059\u308b\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u6838\u5185\u56e0\u5b50NF-\u03baB -\u03b1\u306e\u5206\u89e3\u6291\u5236\u3084\u7d30\u80de\u6838\u5185\u56e0\u5b50NF-\u03baB\u306ep65\u30bf\u30f3\u30d1\u30af\u8cea\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u30ea\u30f3\u9178\u5316\u9632\u6b62\u306b\u3088\u308b\u7d30\u80de\u708e\u75c7\u767a\u751f\u306e\u963b\u5bb3\u304a\u3088\u3073\u708e\u75c7\u6027\u514d\u75ab\u53cd\u5fdc\u30fb\u795e\u7d4c\u6027\u76ae\u819a\u708e\u53cd\u5fdc\u306e\u8efd\u6e1b\u3092\u542b\u3080\u591a\u6a5f\u80fd\u6297\u708e\u75c7\u6d3b\u6027\u3092\u6301\u3064\u3002\u9ea6\u89d2\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u306f\u3001\u816b\u760d\u58ca\u6b7b\u56e0\u5b50TNF-\u03b1\u306e\u8a98\u5c0e\u306b\u3088\u308bNF-\u03baB\u306e\u9175\u7d20\u6d3b\u6027\u5206\u89e3\u3092\u6291\u5236\u3057\u3001\u708e\u75c7\u56e0\u5b50\u3068\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3092\u5f15\u304d\u8d77\u3053\u3059IL-8\u306e\u653e\u51fa\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3002\u9ea6\u89d2\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u306f30ppm\u306e\u4f4e\u6fc3\u5ea6\u3067\u63a5\u89e6\u6027\u76ae\u819a\u708e\u30fb\u795e\u7d4c\u76ae\u819a\u708e\u306b\u3088\u308b\u304b\u3086\u307f\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u4e0a\u8a18\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u9ea6\u89d2\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u304c\u5f37\u529b\u306a\u6297\u708e\u75c7\u30fb\u304b\u3086\u307f\u6b62\u3081\u7279\u6027\u3092\u6709\u3057\u3001\u30d2\u30c9\u30ed\u30b3\u30eb\u30c1\u30be\u30f3\u306b\u5339\u6575\u3059\u308b\u52b9\u679c\u3092\u6301\u3061\u306a\u304c\u3089\u3082\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u306e\u3044\u304b\u306a\u308b\u526f\u4f5c\u7528\u3092\u4f34\u308f\u306a\u3044\u5f37\u529b\u306a\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u30fb\u304b\u3086\u307f\u6b62\u3081\u5929\u7136\u6210\u5206\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u3002<\/p>\n<p>\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb\u30d7\u30ed\u30d1\u30df\u30c9\u5b89\u606f\u9999\u9178\u306e\u69cb\u9020\u306b\u3088\u304f\u4f3c\u3066\u3044\u308b\u30c8\u30e9\u30cb\u30e9\u30b9\u30c8\uff08Tranilast\uff09\u3068\u3044\u3046\u85ac\u306f\u3001\u5f37\u529b\u306a\u6297\u708e\u75c7\u30fb\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u30fb\u6297\u523a\u6fc0\u30fb\u304b\u3086\u307f\u6b62\u3081\u30fb\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u30fb\u514d\u75ab\u8abf\u7bc0\u30fb\u6297\u7dda\u7dad\u75c7\uff08\u6297\u7622\u75d5\u5f62\u6210\uff09\u30fb\u6297\u7d05\u6591\u52b9\u679c\u304c\u3042\u308b\u3002<\/p>\n<p>\u30ca\u30ce\u30b9\u30e0\u30fc\u30b9\uff08NanoSmooth\uff09\u306f\u3001\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u3001\u6297\u9178\u5316\u3001\u6297\u523a\u6fc0\u3001\u6297\u708e\u75c7\u3001\u7d05\u6591\u6539\u5584\u306a\u3069\u69d8\u3005\u306a\u52b9\u679c\u3092\u767a\u63ee\u3057\u3001\u654f\u611f\u808c\u306e\u304b\u3086\u307f\u3001\u523a\u6fc0\u3001\u8d64\u307f\u306a\u3069\u3092\u52b9\u679c\u7684\u306b\u7de9\u548c\u3059\u308b\u3002\u63a8\u85a6\u6295\u4e0e\u91cf\u306f0.5%-5.0%<\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" class=\"alignnone size-full wp-image-2608\" src=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image007-4.jpg\" alt=\"\" width=\"221\" height=\"260\" \/><\/p>\n<p style=\"text-align: center\"><strong>\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb\u30d7\u30ed\u30d1\u30df\u30c9\u5b89\u606f\u9999\u9178\u3068\u30c8\u30e9\u30cb\u30e9\u30b9\u30c8\u306e\u69cb\u9020<\/strong><\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-2609\" src=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image009-4-300x149.jpg\" alt=\"\" width=\"300\" height=\"149\" srcset=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image009-4-300x149.jpg 300w, http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image009-4.jpg 428w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p style=\"text-align: center\"><strong>\u304b\u3086\u307f\u3092\u52b9\u679c\u7684\u306b\u6291\u3048\u308bNanoSmooth<\/strong><\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-2610\" src=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image010-3-300x144.jpg\" alt=\"\" width=\"300\" height=\"144\" srcset=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image010-3-300x144.jpg 300w, http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image010-3.jpg 427w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p style=\"text-align: center\"><strong>\u7d05\u6591\u3092\u52b9\u679c\u7684\u306b\u6e1b\u3089\u3059NanoSmooth<\/strong><\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-2611\" src=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image011-1-300x135.jpg\" alt=\"\" width=\"300\" height=\"135\" srcset=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image011-1-300x135.jpg 300w, http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image011-1.jpg 484w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p style=\"text-align: center\"><strong>\u63a5\u89e6\u6027\u76ae\u819a\u708e\u3092\u52b9\u679c\u7684\u306b\u6291\u3048\u308bNanoSmooth<\/strong><\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" class=\"alignnone size-medium wp-image-2612\" src=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image013-1-300x137.jpg\" alt=\"\" width=\"300\" height=\"137\" srcset=\"http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image013-1-300x137.jpg 300w, http:\/\/www.puriactives.com\/jp\/wp-content\/uploads\/2019\/08\/image013-1.jpg 485w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p style=\"text-align: center\"><strong>\u795e\u7d4c\u6027\u76ae\u819a\u708e\u3092\u52b9\u679c\u7684\u306b\u6291\u3048\u308b<\/strong>NanoSmooth<\/p>\n<p>&nbsp;<\/p>\n<p>\u30ca\u30ce\u4f1d\u9001\u30b7\u30b9\u30c6\u30e0\uff08NDS\uff09\u306b\u3088\u308a\u958b\u767a\u3055\u308c\u305f\u30ca\u30ce\u30b9\u30e0\u30fc\u30b9\u306f\u3001\u30d0\u30a4\u30aa\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3068\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb\u30d7\u30ed\u30d1\u30df\u30c9\u5b89\u606f\u9999\u9178\u306e\u6eb6\u89e3\u6027\u554f\u984c\u3092\u5b8c\u5168\u306b\u89e3\u6c7a\u3057\u3001\u6d3b\u6027\u7269\u8cea\u3092\u30ca\u30ce\u30ad\u30e3\u30ea\u30a2\u306b\u5b89\u5b9a\u306b\u5c01\u5165\u3055\u305b\u3001\u4fbf\u5229\u306b\u6d3b\u7528\u3067\u304d\u3001\u5206\u96e2\u3055\u308c\u306b\u304f\u304f\u3001\u5438\u53ce\u52b9\u7387\u3068\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\u3092\u5927\u5e45\u306b\u5411\u4e0a\u3055\u305b\u308b\u3002<\/p>\n<p>\u88fd\u54c1\u306e\u4f7f\u7528\uff1a\u4f4e\u6e29\u6bb5\u968e\u3067\u5165\u308c\u3001\u63a8\u5968\u7528\u91cf\uff1a0.5-5.0%\u3002<\/p>\n<p>\u88fd\u54c1\u306e\u4fdd\u7ba1\uff1a25\u2103\u4ee5\u4e0b\u306e\u6697\u6240\u3067\u4fdd\u7ba1\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8981\u7d04\uff1a\u30ca\u30ce\u30b9\u30e0\u30fc\u30b9\uff08NanoSmooth\uff09\u306f\u3001\u65b0\u3057\u3044\u30ca\u30ce\u4f1d\u9001\u6280\u8853\u306b\u3088\u3063\u3066\u690d\u7269\u7531\u6765\u306e\u69d8\u3005\u306a\u690d\u7269\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3084\u30d2\u30c9\u30ed\u30ad\u30b7\u30d5\u30a7\u30cb\u30eb\u30d7\u30ed\u30d1\u30df\u30c9\u5b89\u606f\u9999\u9178\u306a\u3069\u3001\u6d88\u708e 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