Intended Use
PuriActives®7-DHC is a high-purity active ingredient designed for advanced cosmetic and personal care formulations. As the natural precursor to vitamin D3, this innovative ingredient harnesses the skin’s inherent photoprotective mechanisms to enhance barrier function and support overall skin health. The product is specifically developed for premium skincare applications where scientifically-backed efficacy and exceptional quality are paramount.
7-Dehydrocholesterol is naturally present in human skin and plays a crucial role in the photoproduction of vitamin D3 upon exposure to UVB radiation. By supplementing the skin’s natural reservoir of this essential sterol, PuriActives®7-DHC helps optimize the skin’s response to environmental stressors while supporting its natural regenerative processes.
Benefits at a Glance
- Enhances skin barrier function and integrity through natural lipid replenishment
- Supports the skin’s natural photoprotective mechanisms and UV defense response
- Promotes skin hydration and moisture retention for improved skin comfort
- Precursor to vitamin D3, supporting skin’s natural vitamin D synthesis pathway
- High purity grade suitable for premium cosmetic formulations
- Compatible with a wide range of cosmetic formulations and delivery systems
INCI (PCPC Name)
Properties
Physical and Chemical Properties
- Crystalline solid at room temperature with characteristic sterol structure
- Lipophilic nature enables excellent skin penetration and bioavailability
- Stable under recommended storage conditions with proper protection from light
- Compatible with oil-based and emulsion formulations
Applications
PuriActives®7-DHC is suitable for a wide range of cosmetic and personal care applications:
- Premium anti-aging creams and serums targeting skin barrier enhancement
- Photoprotection and after-sun care products supporting natural skin defense
- Moisturizing formulations for dry and compromised skin conditions
- Barrier repair creams and sensitive skin formulations
- Premium body lotions and skin conditioning products
- Lip care products and protective balms
Recommended Usage Concentration
The optimal concentration depends on the specific formulation type, desired efficacy, and target consumer needs. We recommend conducting compatibility and stability testing for each specific formulation. For new product development, starting with 0.5% is suggested for most applications.
Formulation Guidelines
PuriActives®7-DHC should be incorporated into the oil phase of emulsions during the manufacturing process. The ingredient dissolves readily in warm oils (60-80°C) and can be added to the oil phase before emulsification. For anhydrous formulations, dissolve the ingredient in the oil base with gentle heating. Avoid prolonged exposure to high temperatures and protect from light during processing.
Handling Precautions
- Avoid formation of dust during handling; use appropriate dust control measures
- Use in well-ventilated areas or under local exhaust ventilation
- Wear appropriate personal protective equipment (gloves, safety glasses)
- Avoid contact with eyes, skin, and clothing; wash thoroughly after handling
- Do not eat, drink, or smoke while handling this product
Storage and Handling
Store in original containers in a cool, dry, well-ventilated area. Protect from light and moisture. Keep away from heat sources and open flames. Ensure containers are properly sealed after each use to maintain product quality and prevent contamination.
Scientific Findings
7-Dehydrocholesterol is a naturally occurring sterol that serves as the immediate precursor to vitamin D3 (cholecalciferol) in the human body. Scientific research has demonstrated several key findings regarding its role in skin health and function:
- 7-Dehydrocholesterol is present in the epidermis and is converted to previtamin D3 upon exposure to UVB radiation (290-320 nm), which then thermally isomerizes to vitamin D3
- As a component of the skin’s lipid matrix, it contributes to the structural integrity and barrier function of the stratum corneum
- Studies suggest that topical application of 7-dehydrocholesterol may help support the skin’s natural photoprotective response mechanisms
- The molecule’s lipophilic nature enables effective penetration through the stratum corneum, supporting its bioavailability in skin tissues
- Research indicates potential benefits for skin barrier enhancement and moisture retention through lipid replenishment
Specifications
Safety Information
PuriActives®7-DHC is not classified as hazardous according to Regulation (EC) No 1272/2008 (CLP). The substance has a favorable safety profile based on available toxicological dataand its natural occurrence in human skin. However, standard laboratory and manufacturing safety practices should be followed when handling this product.
For detailed safety information, please refer to the Safety Data Sheet (SDS) available upon request. The product is intended for cosmetic use only and should not be used in pharmaceutical or food applications without appropriate regulatory approval.
Regulatory Status
Packaging
Contact Information
DISCLAIMER
The information provided in this Product Data Sheet is based on our present knowledge and experience. It is intended to provide general guidance on the use of our product and does not constitute a warranty or guarantee of any specific results. Users should conduct their own tests to determine the suitability of the product for their intended applications. PuriPharm Co. Ltd. assumes no liability for any results obtained through the use of this product. The information contained herein is subject to change without notice. For the most current information, please contact our technical service department.
PuriPharm Co. Ltd. | PuriActives®7-DHC | February 2026