Intended Use

PuriActives®7-DHC is a high-purity active ingredient designed for advanced cosmetic and personal care formulations. As the natural precursor to vitamin D3, this innovative ingredient harnesses the skin’s inherent photoprotective mechanisms to enhance barrier function and support overall skin health. The product is specifically developed for premium skincare applications where scientifically-backed efficacy and exceptional quality are paramount.

7-Dehydrocholesterol is naturally present in human skin and plays a crucial role in the photoproduction of vitamin D3 upon exposure to UVB radiation. By supplementing the skin’s natural reservoir of this essential sterol, PuriActives®7-DHC helps optimize the skin’s response to environmental stressors while supporting its natural regenerative processes.

Benefits at a Glance

• Enhances skin barrier function and integrity through natural lipid replenishment
• Supports the skin’s natural photoprotective mechanisms and UV defense response
• Promotes skin hydration and moisture retention for improved skin comfort
• Precursor to vitamin D3, supporting skin’s natural vitamin D synthesis pathway
• High purity grade suitable for premium cosmetic formulations
• Compatible with a wide range of cosmetic formulations and delivery systems

INCI (PCPC Name)

Properties

Physical and Chemical Properties

• Crystalline solid at room temperature with characteristic sterol structure
• Lipophilic nature enables excellent skin penetration and bioavailability
• Stable under recommended storage conditions with proper protection from light
• Compatible with oil-based and emulsion formulations

Applications

PuriActives®7-DHC is suitable for a wide range of cosmetic and personal care applications:

• Premium anti-aging creams and serums targeting skin barrier enhancement
• Photoprotection and after-sun care products supporting natural skin defense
• Moisturizing formulations for dry and compromised skin conditions
• Barrier repair creams and sensitive skin formulations
• Premium body lotions and skin conditioning products
• Lip care products and protective balms

Recommended Usage Concentration

The optimal concentration depends on the specific formulation type, desired efficacy, and target consumer needs. We recommend conducting compatibility and stability testing for each specific formulation. For new product development, starting with 0.5% is suggested for most applications.

Formulation Guidelines

PuriActives®7-DHC should be incorporated into the oil phase of emulsions during the manufacturing process. The ingredient dissolves readily in warm oils (60-80°C) and can be added to the oil phase before emulsification. For anhydrous formulations, dissolve the ingredient in the oil base with gentle heating. Avoid prolonged exposure to high temperatures and protect from light during processing.

Handling Precautions

• Avoid formation of dust during handling; use appropriate dust control measures
• Use in well-ventilated areas or under local exhaust ventilation
• Wear appropriate personal protective equipment (gloves, safety glasses)
• Avoid contact with eyes, skin, and clothing; wash thoroughly after handling
• Do not eat, drink, or smoke while handling this product

Storage and Handling

Store in original containers in a cool, dry, well-ventilated area. Protect from light and moisture. Keep away from heat sources and open flames. Ensure containers are properly sealed after each use to maintain product quality and prevent contamination.

Scientific Findings

7-Dehydrocholesterol is a naturally occurring sterol that serves as the immediate precursor to vitamin D3 (cholecalciferol) in the human body. Scientific research has demonstrated several key findings regarding its role in skin health and function:

• 7-Dehydrocholesterol is present in the epidermis and is converted to previtamin D3 upon exposure to UVB radiation (290-320 nm), which then thermally isomerizes to vitamin D3
• As a component of the skin’s lipid matrix, it contributes to the structural integrity and barrier function of the stratum corneum
• Studies suggest that topical application of 7-dehydrocholesterol may help support the skin’s natural photoprotective response mechanisms
• The molecule’s lipophilic nature enables effective penetration through the stratum corneum, supporting its bioavailability in skin tissues
• Research indicates potential benefits for skin barrier enhancement and moisture retention through lipid replenishment

Specifications

Safety Information

PuriActives®7-DHC is not classified as hazardous according to Regulation (EC) No 1272/2008 (CLP). The substance has a favorable safety profile based on available toxicological dataand its natural occurrence in human skin. However, standard laboratory and manufacturing safety practices should be followed when handling this product.

For detailed safety information, please refer to the Safety Data Sheet (SDS) available upon request. The product is intended for cosmetic use only and should not be used in pharmaceutical or food applications without appropriate regulatory approval.

Regulatory Status

Packaging

Contact Information

DISCLAIMER

The information provided in this Product Data Sheet is based on our present knowledge and experience. It is intended to provide general guidance on the use of our product and does not constitute a warranty or guarantee of any specific results. Users should conduct their own tests to determine the suitability of the product for their intended applications. PuriPharm Co. Ltd. assumes no liability for any results obtained through the use of this product. The information contained herein is subject to change without notice. For the most current information, please contact our technical service department.

PuriPharm Co. Ltd. | PuriActives®7-DHC | February 2026

随着护肤科学的普及，消费者对“抗老”的需求已从简单的成分堆砌转向“转化效率”的追求。近期，The Inkey List 推出的Advanced 0.2% Retinal Serum正处于这一浪潮的中心。

1. 核心科学：为什么是视黄醛（Retinal）？

在维 A 家族的转化路径中，成分需要转化为**视黄酸（Retinoic Acid）**才能在皮肤上发挥生物活性：

转化效率的降维打击

• Retinol（视黄醇/A醇）： 需要两次转化才能生效。在转化过程中，有效成分会由于酶的活性、个体差异等因素大量损耗。
• Retinal（视黄醛/A醛）： 仅需一步转化即可成为视黄酸。研究表明，视黄醛的转化效率最高可达视黄醇的11倍，这意味着更低浓度的视黄醛就能达到甚至超过高浓度视黄醇的效果。

2. 政策推动：欧盟 0.3% 限额引发的洗牌

欧盟 SCCS（消费者安全科学委员会）近期对护肤品中维 A 类成分提出了浓度限制建议：

●面部和手部产品中，视黄醇（Retinol）及其衍生物的最大浓度限制在0.3% RE（视黄醇当量）。

这一政策对传统品牌造成了巨大冲击：

1. 高浓度 A 醇失去合法性： 过去市场追求 1.0%甚至更高浓度的 A 醇产品，但在新规下将无法在欧盟销售。
2. 视黄醛的降临： 由于视黄醛在 0.1% – 0.2% 的浓度下就能展现出卓越的抗老效果，它完美避开了 0.3% 的限制天花板，同时提供了比 0.3% A 醇更强的功效。

3. 产品拆解：The Inkey List Advanced 0.2% Retinal Serum

The Inkey List此次推出的产品定位清晰，主要针对进阶抗老用户。

技术亮点

• 0.2% 高浓度： 市场上主流视黄醛产品多为 0.05% 或0.1%（如 Avene 或 Medik8 的入门款）。0.2% 属于高阶浓度，直接对标专业级抗老。
• 缓释包裹技术： 视黄醛极其不稳定且有一定刺激性。该产品采用了脂质体或其他包裹技术，确保成分缓慢释放，降低对皮肤屏障的瞬间冲击。
• 辅助成分： 通常配伍有透明质酸、角鲨烷或泛醇，用于缓解 A 醛带来的干燥和脱屑现象。

优劣势评估

4. 市场观察：谁在竞争？

视黄醛赛道目前已进入“混战”阶段：

1. Medik8 Crystal Retinal 系列： 该赛道的标杆，提供从 0.01% 到 0.2% 的分级梯度，但价格昂贵。
2. Geek & Gorgeous A-Game： 欧洲高性价比代表，拥有 0.05% 和 0.1% 版本。
3. The Inkey List： 通过 0.2% 的高浓度和极致的价格竞争力，试图直接截流 Medik8 的高端用户。

5. 消费建议

如果您准备尝试这款0.2% 视黄醛精华：

1. 建立耐受： 遵循 “Low and Slow” 原则。第一周每周两次，逐渐增加频率。
2. 晚间使用： 维 A 类成分具有光敏性，仅限夜间使用。
3. 精简护肤： 使用期间避免同时使用高浓度酸类（AHA/BHA）或高浓度维 C。
4. 防晒： 白天必须严格涂抹 SPF 30+ 以上的防晒霜。

总结：视黄醛的崛起是护肤品从“浓度游戏”回归到“科学转化”的标志。The Inkey List 的这款新品不仅是应对法规的产物，更是平价替代高端抗老产品的又一力作。