Magnano Magnolia officinalis Extract Nanoemulsion
Magnolia officinalis is an important herb of traditional Chinese medicine, which has been included in the Chinese pharmacopoeia. Magnolia officinalis barks contain two anti-inflammatory isomers, magnolol and honokiol. Magnolia officinalis barks have been used in Asia for more than a thousand years in the treatment of qi stagnation (lassitude), digestive disorders, anxiety, and allergic diseases. Magnolia officinalis extract nanoemulsion uses nano-technology to encapsulate magnolol and honokiol, the main active matters of magnolia officinalis extract, to solve the problem of solubility, making it more stable and easier to be absorbed so that it can better perform its activity of anti-inflammation, anti-aging, anti-aging, anti-bacterial, etc.
Magnolol and honokiol a traditional Chinese medicine Magnolia officinalis
Wide Application of Magnolia Officinalis Extract in Medicine
Inflammation is the first body response to infection or irritation, manifested by partially increased blood flow, migration and activation of immune cells in the affected area, release of numerous free radicals, and destruction towards normal tissues. Ideally, inflammation can clear the infection and then resolve spontaneously, allowing normal tissues to rebuild. But inflammation can become chronic (for example, the infection does not completely disappear, or the inflammatory response becomes very sensitive, or the inflammatory response is caused by an autoimmune response). In addition, as we grow older, we are more and more prone to chronic inflammation. Chronic inflammation caused by free radicals will particularly accelerate the aging process.
Inflammation Caused by Free Radicals
Chronic inflammation is a key risk factor as we age, and it is now considered as one of the key risk factors for aging diseases such as heart disease and stroke. Inflammation is also deemed as the cause of some age-related common neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Studies have found that when a person is feeble, there is usually an excess of one or more inflammatory factors inside him, such as TNF-a (tumor necrosis factor), IL-6, IL-1 (b), or IL-8 (leukocyte hormone). Inflammatory aging becomes a major challenge for human health.
Inflammatory Aging
Studies have shown that the main active matters in the magnolia officinalis extract are magnolol and honokiol. Magnolol and honokiol are effective in removing oxygen free radicals from the body. By inhibiting the activation of NF-ĸB (transcription factor), magnolol and honokiol produce a synergistic anti-inflammatory effect. In addition, they have antioxidant, antibacterial and anti-angiogenic effects while reducing harmful substances. Magnolol and honokiol also have a very strong anti-allergic effect.
Magnolia officinalis has strong antibacterial effect. Its antibacterial spectrum is wide, and the antibacterial property is stable, which will not be easily damaged by heat, acid and alkali. It has a strong inhibitory effect on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, etc., and has an inhibitory effect on common pathogenic skin fungi.
Better Anti-propionibacteria Activity of Magnolol and Honokiol than Erythromycin
Minimum Inhibitory Concentration (MIC) of Magnolol and Honokiol against Propionibacterium
Higer Transdermal Efficiency of Nanoemulsion Encapsulated Active Matters than Traditional Preparations
Product Features:
- Magnano uses materials of FDA GRAS class, so it is very safe
- Magnano is stable to heat, pH and cuts, so it is convenient to use
- Magnano greatly improve the solubility, stability and bioavailability of plant polyphenols.
- Magnano can improve the stability of other active matters in the product and facilitate absorption
- Magnano itself has good antibacterial activity without preservatives
Wide Application of Magnano in Skincare Products
Use of Product:Add it at a low temperature. It is suitable for anti-aging, anti-inflammation, anti-oxidation products, etc.
Recommended dosage:0.1-5%。Better effect with products containing nano-astaxanthin, etc.
Storage of Product: keep it away from light at a temperature below 25℃.
Synbiotics Skin Micro-ecological Nanoemulsion BioNanoCare
A perfect match of biopharmaceutical technology and nanotechnology
Description: With the rise of skin microbiology, the combination of probiotics and prebiotics (i.e., Synbiotics) targeting the removal of bacteria harmful to skin with targets has been the latest trend in the materials of international skincare and skincare products. BioNanoCare is a nano-encapsulated synbiotic designed for the skin micro-ecological balance and skin repair, using modern biological and nano-technology, combined with probiotics and prebiotics, and targeting bacteria harmful to skin. With advantages of safety, high efficiency and environmental friendliness, it will not kill good bacteria together with bad ones like traditional antibiotics. The nano-encapsulated probiotics extract can provide nutrients and moisture for skin repair, thereby moisturizing, preventing aging and wrinkles and inhibiting pigmentation, so that the skin will return to normal. The nano-encapsulated prebiotics can effectively promote the proliferation of probiotics on the skin surface, thereby inhibiting the growth of harmful bacteria, restore the micro-ecological balance of skin as soon as possible, and keep the skin young. Specially added water-soluble yeast glucan can effectively activate skin Langerhans cells, and play a role in anti-inflammation, anti-allergy, eliminating the activity of radicals, moisturizing and accelerating the renewal of the stratum corneum, helping the skin resist external exogenous various mechanical and chemical stimuli and promoting the recovery of injuries.
Saccharomyces cerevisiae Fructo oligosaccharide Lactobacillus
Fungi, bacteria and viruses on the surface of human skin constitute a complex microbial ecosystem called the “skin microbiome”. Microbiome study is becoming popular in the biomedical field. In May 2016, the White House announced the launch of the National Microbiome Initiative (NMI), aiming to promote the development of microbial science, benefiting individuals, communities and all of humanity in the areas of health care, food production, environmental protection, etc. As a hot theme in biomedicine, microbiome is expanding into the field of skin research. The international renowned pharmaceutical company Johnson & Johnson also announced the establishment of the Johnson & Johnson Human Microbiome Research Center in February last year. In recent years, the company has endeavored a lot to develop the role of microbiome in the development of new drugs. It is reported by Happi that Johnson & Johnson Consumer Inc. has reached an agreement with Xycrobe Therapeutics, a US biotechnology startup, to further cooperate on the treatment of inflammatory skin diseases.
The research team led by the National Institute of Allergy and Infectious Diseases (NIAID) published an article in Nature(Jan 5, 2015), stating that the skin microbiome can significantly affect immunity. The researchers transplanted different types of symbiotic bacteria into mice to prompt them to produce specific immune cells of symbiotic bacteria. After the transplantation of S.epidermidis, a common skin symbiotic bacterium, onto the skin of mice, the number of CD8+T cells is increased, and this immune cell can produce the chemical messenger IL-17A. Studies have shown that Staphylococcus epidermidis can enhance immunity to specific pathogens without causing inflammation. Different types of skin symbiotic bacteria can cause different immune responses, which indicates that immune cells in skin can quickly sense and respond to changes in the skin flora. These findings help explain the protective role of skin symbiotic bacteria and to reveal the specific mechanisms of how flora changes cause skin diseases.
Human Skin Microbial Map
The paper “Temporal Stability of the Human Skin Microbiome” published in Cell(May 5, 2016) reported a new metagenomic study which shows that despite frequent cleaning and exposure to bacteria-rich objects, our individual skin microbial environment remains highly stable after a period of time. This recognition can be used to better understand a range of human skin diseases, thus helping to develop prebiotic, probiotic and microbial transplantation.
According to a survey of the World Health Organization (WHO), among the yellow races, people whose skin is in a healthy state account for less than 10%, more than 20% are in a morbid state, and 70% are in a sub-healthy state. The past 30 years has seen the significant growing trend of skin diseases in the world. The abuse of antibiotics and hormones has led to more and more skin diseases caused by the environment, e.g., eczema, acne, hormonal dermatitis, cosmetic-dependent dermatitis, seborrheic dermatitis, etc. With the development of biomedicine, the study found that 95% of skin diseases show a skin micro-ecological imbalance.
Micro-ecological balance refers to the dynamic balance of normal combination of normal micro-organisms and their host ecosystems during the long-term evolution process. On the surface of the normal person, i.e., on the surface of the skin and internal parts, there are numerous microorganisms. The floras on the skin surface is divided into resident and temporary ones, most of which are beneficial to our body, such as clearing the waste on the skin surface (apoptotic cells), decomposing excessive lipids, resisting the invasion of foreign pathogens through competitive inhibition, etc. When the balanced relationship is broken, the skin function will be disordered, which causes diseases. Therefore, the Human Microbiological Program funded by the National Institutes of Health has been implemented to explore the characteristics and role of human micro-ecology. Recently, researches on skin micro-ecology have also received increasing attention from dermatologists. The balance and stability of floras have an important impact on the physiological function of bodies. The balance and stability of the in vivo floras directly affects the barrier effect of the skin surface on the external defense, and can obviously promote the balance of floras and improve the immunity.
Billions of bacteria that inhabit human bodies form a tiny ecosystem, which is necessary for maintaining normal human growth. Guts, oral cavity, skin and vagina are the four major bacteria banks of human bodies. Various and numerous bacteria are included, hundreds of which have been separated and identified.
Skin Microbes – an Important Part of the Skin Barrier
Probiotics, the concept of which originates from Greek, means “for life”. In short, probiotics are often called “friendly bacteria” because they play a role in good health by supplementing an appropriate amount of them. There are 10 trillion bacteria in a human body, weighing approx. 1.5 kg. The bacteria include both harmful and beneficial ones. The beneficial ones, also known as probiotics, are friendly bacteria that are good for your health. They enhance and maintain the natural balance of micro-ecology, which is a very important balance for general health and immune system as well. The beneficial bacteria or fungi in human and animal bodies are mainly: bifidobacteria, lactic acid bacteria, Clostridium butyricum, Lactobacillus acidophilus, saccharomycete, etc.
Skin Micro-ecological Balance
Studies have shown that the use of microorganisms to stimulate the development of the Th1 immune system and supplement probiotics can effectively stimulate immune cells to produce interferon, IL-10 and other cytokines, improve sensitive constitution and immunity. Probiotic therapy is a safe and effective method for the treatment of eczema. Probiotics can significantly promote the development and maturation of the immune system as well as the injury recovery, change sensitive constitution, gradually reduce the frequency and degree of allergic attacks until they disappear, fundamentally regulate the sensitive constitution, enhance immunity, and thoroughly treat allergic diseases. Nanoemulsion is a new type of safe and effective immune adjuvant. Synbiotic nanoemulsion can better enhance the immune regulation and repair capacity of probiotics.
In theory, human guts, oral cavity, skin and other tissues and organs all contain bacteria. Moreover, probiotics and harmful bacteria coexist. If there are more probiotics, the proportion of harmful bacteria will be less, and vice versa. Supplementing probiotics is the safest, the most direct and effective method for detoxification and beauty. It can inhibit the growth of harmful bacteria and reduce the production of toxins. Probiotics can gradually restore the partial micro-ecological balance of skin, resist the invasion and growth of harmful bacteria, reduce skin’s absorption and deposition of pigment, make the pigmentation fade away, and solve cosmetic problems from within. It also has a positive therapeutic effect on the treatment of acne, chloasma and other skin diseases. A growing number of studies have shown that skin microbes can promote the skin barrier and natural barrier to form a perfect balance so as to maintain the skin health.
Micro-ecological adjustment to solve skin problems – handle bacteria with bacteria
Prebiotics can have a positive effect on the hosts and improve the health of hosts by selectively stimulating the growth and activity of one or several bacteria. Prebiotics only proliferate bacteria (probiotics) that are beneficial to humans, but do not proliferate harmful bacteria that have potential pathogenic or spoiling activity to humans. In general, prebiotics are the “nutrition” of human probiotics. Therefore, the addition of high-quality prebiotics to skincare products can help the skin recover and maintain a micro-ecological balance, thus ensuring normal skin barrier function.
Synbiotics can promote the growth of beneficial bacteria and inhibit the growth of harmful bacteria
“Synbiotics” refers to the combination of probiotics and prebiotics. The combination of nano-encapsulated prebiotics and probiotic strains produces a synergistic effect that leads to more physiological benefits. The nano-encapsulated probiotic extract can provide nutrients and moisture for skin repair, thereby moisturizing, preventing aging and wrinkles and inhibiting pigmentation, so that the skin will return to normal. The nano-encapsulated prebiotics can effectively promote the proliferation of probiotics on the skin surface, thereby inhibiting the growth of harmful bacteria, restore the micro-ecological balance of skin as soon as possible, and keep the skin young. Synbiotics can also promote the expression of endogenous cationic antibacterial peptides (β-defensins) hBD2 and hBD3. β-defensins can directly bind to the surface of pathogens and destroy them, and prevent the invasion of certain viruses. Cellular test results showed that 0.5% BioNanoCare could promote the expression of hBD2 gene by 51%. In vitro biological tests found that 3% BioNanoCare could promote the expression of hBD3 gene by 72%.
The hair follicles and sweat glands are moist and nutritious, making them ideal for microbial enrichment. The nano-encapsulated synbiotics facilitate the entry of probiotic active matters and prebiotics, promote the growth of beneficial microbes, inhibit the growth of harmful microbes, thus maintaining the skin micro-ecological balance and a good skin barrier function.
Special Hair Follicle targeting Effect of Nanoparticle Preparations
The smaller the particle size is, the stronger the adhesion effect is. Nanoparticles can form a good occlusion effect on the skin and increase the moisturizing performance of skin
Unique Closure Effect of Nanoparticle Preparations
Yeast is relatively early applied by humans, and is the most widely used microbe. People often use its fermentation to produce a variety of fermented food and wine. Meanwhile, yeast is also a multi-biological therapeutic drug, which is included in the monograph written by the German Commission E (the German statutory herbal pharmacopoeia) as an antibacterial and anti-inflammatory herb that treats acnes. In recent years, the biochemical technology has been developing continuously, especially the progress of fermentation technology. It has continuously produced high-efficiency and innovative yeast extracts. Their most prominent functions are anti-aging, deep repair, skin regeneration and anti-UV protection, anti-allergy soothing, etc. The β-glucan in the yeast wall is a key substance for yeast to exert antibacterial and anti-inflammatory effects.
Schematic Diagram of Yeast β-glucan Structure
In the epidermis, the immune system of skin includes plasma cells, Langerhans cells, and keratinocytes. In recent years, Langerhans cells have been confirmed to have a very special relationship with macrophages in the skin, and play an extremely important role in skin immunity. There are many immune networks composed of Langerhans cells under the stratum corneum of the skin. Langerhans cells are dendritic cells, and their antennae can reach the stratum corneum cells with the receptor CR3 of yeast β-glucan. The binding of glucan to the receptor causes a series of stereo chemical changes that activate macrophages, produce various cytokines (e.g., IL-1, IL-6, GM-CSF), epidermal growth factor (EGF), tumor necrosis (TNF-α) and angiogenic factor (AF). On aging or wrinkled skin, an increase in epidermal growth factor can promote the production of collagen and elastin, thus improving the exterior of skin and eliminating small wrinkles.
Schematic Diagram of the Biological Activity of Yeast Glucan
Studies have also shown that UV radiation has an inhibitory effect on Langerhans cells in the skin. If the skin is exposed to the sun for a long time, the number and activity of Langerhans cells will be greatly reduced, and the defense immunity of skin will be weakened. In addition to its own sunscreen effect and the ability to relieve pain and inflammation, β-glucan can also promote the proliferation of Langerhans cells and enhance skin immunity. Clinical studies have also shown that yeast glucan plays a role in anti-inflammation, anti-allergy, eliminating the activity of radicals, moisturizing and accelerating the renewal of the stratum corneum, helping the skin resist external exogenous various mechanical and chemical stimuli and promoting the recovery of injuries. Experiments have proved that yeast glucan can significantly reduce the skin allergic inflammation caused by stimulating active ingredients such as fruit acids.
Healing Effect for Couperose Skin
Healing Effect for Rashes
Application of BioNanoCare in Cosmetics
BioNanoCareis made from natural raw materials so it is non-toxic and non-irritating. It is added to skincare products to help rebuild or maintain good skin micro-ecology and skin barrier, reduce irritation, renew and repair stressed skin, effectively reduce skin wrinkles, improve skin moisture retention and smoothness, promote the recovery and regeneration of scars, brighten the skin, and treat specific dermatitis. It is widely used in anti-wrinkle and anti-aging products, sunscreen and after-sun care products, soothing products for sensitive skin and other high-end cosmetics.
Instruction for Prescription
Solubility: This product is easily soluble in water.
Recommended dosage: The product is added in an amount of 1-10%. It is recommended to add this below 50℃in the final stage of cosmetic production. It is compatible with a wide range of cosmetic ingredients.
BioActive Sugar
| Glycoin® natural is a main active element of myrothamnus flabellifolia , which is necessary for it to survive in a long drought.Glycoin® natural revives myrothamnus flabellifolia — it can activate the cells in the long drought (up to 50 years!), and bring a new life to the myrothamnus flabellifolia. Glycoin® natural can also be produced by halotolerant blue-green algae, and protect bodies from the damage of osmotic pressure. Glycoin® natural When the lipid bilayer is dehydrated, small molecule solutes like glycoin® natural can lower the addition value of temperature during the fluid-gel conversion. This may be explained with the effect of distance among membranes. How do small molecule solutes affect the interaction among membranes is mainly connected with water. Natural cell activators |
PuriBifido
INCI Name :Bifida Ferment Lysate
Bifida Ferment Extract, Phenoxyethanol, Potassium Sorbate, Xanthan Gum
CAS No. None for now; 122-99-6; 24634-61-5; 11138-66-2
It is fermented by the compound bifidobacteria (known as bifidus yeast in the industry). It is a probiotic product that thoroughly improves the skin condition and can be classified as a skin micro-ecological active matter. The core ingredient of the Estee Lauder Advanced Night Repair is the bifidus yeast. The anti-ageing active ingredients extracted from the lysate of bifidobacteria through biotechnology can effectively protect skin, reduce the damage caused by ultraviolet rays to the skin, activate the immuno-suppressive process, stimulate endogenous skin protection, and promote cell repair. It can reduce skin spots, brighten the skin, reduce the number and degree of wrinkles, and smooth the skin. Bifidus yeast can promote cell repair and support the endogenous protection mechanism to fight against skin aging.
PuriBifido is created through the fermentation of composite bifidobacterium (commonly known as Bifida) groups. It is a bifidobacterium derivative that can completely improve skin states with the
Specification
| Exterior | Opaque light yellow fluid |
| Smell | Slight featured acid smell |
| pH | 4.0~6.0 |
| Total solids | ≥ 3.0 % |
| Nitrogen level | 0.1~0.15% |
| Total amount of fungi | ≤ 50 CFU/ml |
| Total amount of bacteria | ≤ 300 CFU/ml |
| Heavy metal | ≤ 40 ppm |
Recommendation for use
Recommend dosage: 5.0~20.0%. An addition may be applied if required.
- This product is a suspension, so there may be a few sediments after being left still for a long time, which is normal. Please shake it up before use.
- It is recommended to add thickener in the prescription so as to prevent bacteria pieces from subsiding. The specific prescription shall be determined after testing.
- Use it at the temperature lower than 60℃, and add it to the aqueous phase.
- If this product is mixed with high-concentration alcohols, the flocculation precipitation will occur. The maximum allowable alcohol concentration is 30% according to the prescription.
- If this product contacts a strongly acidic/alkaline environment, the flocculation precipitation and color change will occur. It should be avoided to directly add the product to such environment.
Rosewood extract nanoemulsion (pTeroNano)
Pterocarpus Santalinus Wood Extract Nanoemulsion
Being a precious kind of wood, rosewood can be developed for skincare. It has been recorded in Shizhen Li’s “Compendium of Materia Medica” in the Ming Dynasty as a valuable Chinese herbal medicine that helps blood circulation and removes blood stasis. Study has found that pterostilbene is one of the most important active ingredients in rosewood. Pterostilbene is a structural homologue of resveratrol. Recently, it has been found to increase the activity of Sirtuin 1 (deacetylase) by 12 times, which helps delaying aging and prolonging lifespan. Compared with resveratrol, pterostilbene can be more easily absorbed, with good bio-pharmaceutical response, more stable metabolism, stronger effects of anti-oxidation and anti-cell proliferation, a longer half-life (over 7 times that of resveratrol), better clinical effect. It can better reduce NF-κB, iNOS and other anti-inflammatory markers. It can also selectively inhibit COX-2, with an antibacterial ability 5-10 times that of resveratrol. Pterostilbene can effectively inhibit the formation of melanin, brighten the skin, and protect the skin from UV damage. With the pterostilbene nanoemulsion developed by nano-transport system, Puripharm effectively solve the application problems of low solubility, poor stability and easy discoloration so that it can be easily applied to various skincare products.
Pterostilbene is a derivative in which the third and the fifth of phenolic hydroxyl groups of resveratrol are substituted by methoxy groups. In recent years, it has been increasingly recognized for its potential effects of anti-cancer, anti-oxidation, anti-inflammatory and anti-diabetic. Although the amount and position of the hydroxyl group are usually the main factors determining the biological activity of the natural polyphenol product, pterostilbene, with only the 4-position hydroxyl group, exhibits an antioxidant activity equal to or even stronger than that of resveratrol. In the cell-free system, pterostilbene has an antioxidant capacity similar to that of resveratrol. In terms of protecting erythrocyte membrane from lipid peroxidation, pterostilbene is significantly more effective (IC50 = (44.5 ± 7.8) μmol / L) than resveratrol. Pterostilbene is also known as “second-generation resveratrol”.
Resveratrol Pterostilbene
Pterostilbene (Pter) is more effective in preventing ultraviolet rays from causing inflammation than resveratrol (Resv).
Protective effects of Pter and Resv from skin cancer caused by UV irradiation
The main problems hindering Pterostilbene’s application in cosmetics are its chemical instability, discoloration and low solubility. Rosewood extract nanoemulsion developed with nano drug-delivery technologysolves the above problems well while retaining pterostilbene’s intrinsic biological activity. Therefore it can be easily and effectively used in various cosmetics, better absorbed, and function better in whitening, anti-inflammatory and sunburn repair.
Nanoemulsion is more active than traditional preparations
Product Features ：
- pTeroNano uses FDA GRAS grade materials for higher safety.
- pTeroNano is stable to heat, pH, and cuts, so it is convenient to use.
- pTeroNano A huge improvement in pterostilbene’s solubility, stability and bioavailability of pterostilbene
- pTeroNano It can improve the stability of other active substances in the product and facilitate absorption
Product use: add under low temperature , pTeroNano has a small amount of positive charge (helps nanocarriers attach to and be absorbed by the skin). If there is much negative charge in the formulation system, you must add pTeroNano before diluting it with pure water, or adjust the dosage, or purchase customized uncharged product from the manufacturer.
Recommended dosage ：0.5-5%。Better effect with products containing nano-retinene, nano-astaxanthin, etc.
Product Storage: keep it away from light at a temperature below 25℃.
NanoSmooth
Abstract: NanoSmooth is a new multi-effect skin care active product that developed by using a new type of nanochannel delivery technology which combines anti-inflammatory, anti-itching, and antibacterial healing active compounds such as plant polyphenols and dihydro-o-alkali alkaloids. This skin care active has the functions of repairing barrier, evening skin color, reducing fever and redness, etc
As people’s awareness of health and environmental protection enhances, active matter derived from plants is getting more and more attention. Plant polyphenols (PPs) are a kind of substance that plants produce to resist natural enemies, competitors, infections and physical injuries. Currently, over 8000 kinds of plant PPs have been discovered. Plant PPs’ abilities of UV absorption, anti-oxidation, radical clearance, metal complexation and antibiosis functions are similar among plants, animals and humans. Many PPs also have the activity of anti-inflammation, anti-allergy, micro-circulation facilitation, anti-tumor, etc., thus are widely being used in fields such as medicine, functional food and cosmeceuticals. The first plant medicine approved by FDA is VEREGEN, a tea polyphenol ointment. The annual sales amount of salvia polyphenol acid salt that Shanghai Green Valley cure cardiovascular diseases through injection has exceeded one billion yuan.
The unique physical, chemical and biological properties enable the plant PPs to be a natural skin protector against the injuries caused by UV (e.g. inflammation, light aging and canceration) as well as the antibiotics against skin fungus and bacterial infection. Besides, there are many important phenylalanine metabolites in human bodies (e.g. estrogen, thyroxine, tyrosine and dopamine), which are quite similar to the plant PPs derived from phenylalanine. Hence, plant PPs used in human bodies can easily enter the metabolism channel, replacing or competing with endogenous phenylalanine metabolites. This provides a theoretical basis for the plant PPs skincare products that include the functions of brightening, anti-aging, anti-acne, anti-alopecia, brightening and anti-hypertrichosis. As for the anti-inflammation effect closely combined with facilitating the recovery of injuries, not only is it attributed to the anti-oxidation, radical clearance, metal complexation, etc., of plant PPs, but also it depends on the interaction between plant PPs and regular inflammatory cells (e.g. keratinocyte) and collected inflammatory cells (e.g. granulocyte, lymphocyte and dendritic cells) of skin. From the perspective of molecular biology, plant PPs restrain the expression and activation of many pro-inflammatory enzymes by reacting with certain surface receptors, and regulating signal transmission channels and inflammation reaction. The extensive molecular targets make plant PPs become the most promising partly applied active matter for anti-inflammation, anti-allergy and injury recovery. Plant PPs can induce the production of enzymes that eliminate carcinogenic toxin and restrain harmful substance from converting into the final carcinogenic enzymes, thus detoxifying and preventing cancers.
The main problems that hinder the application of plant PPs in cosmetics are the chemical instability, interaction with other ingredients, low permeability and fast metabolism in skin. NanoSmooth, developed through nano-medicine technology, solves the above problems well while maintaining the original biological activity of the plant polyphenols so that it can be applied to varieties of cosmetics.
TRPV1 channel, also known as capsaicin receptor, chemical components such as capsaicin, pH<6, temperature>42°C and substance P (SP) can activate the channel, causing cations such as Ca2+inflow and K+outflow. This results in the release of SP and calcitonin gene related peptide (CGRP), causing nociceptive pain [9]. Many TRPV1 channel modulators, including natural products, have been shown to effectively alleviate pain in a variety of animal models, and TRPV1 has become an important target standard for the development of analgesic drugs.
Capsaicin receptor protein structure
So far, more than 100 natural regulators targeting TRP channels have been found in nature, including alkaloids, terpenoids, phenols, peptides, flavonoids, etc., involving more than 70 species of animals and plants. Most of the modulators increase or decrease intracellular Ca2+levels by activating or inhibiting TRP channels, resulting in desensitization of nerve endings, induction of endogenous release, etc. Animal tests have demostrated that actives have abilities such as analgesia, anti-inflammation and nervous system protection, etc.
Scientific research shows that plant polyphenols such as resveratrol and gallnut extract are safe and efficient TRPV1 antagonists, which play an anti-inflammatory and analgesic role. Japanese scientist Yoshihito Shimazu et al. showed that the analgesic effect of partial use topical 10 mM resveratrol is comparable to 37 mM (1%) lidocaine (Brain Research Bulletin, http://dx.doi.org/10.1016/j.brainresbull.2016.06.001）.
NanoSmooth targets TRPV1 target mechanism
Dihydrotomatine alkaloids are derived from the active ingredient of oats (Avenasativa) and have rapid anti-inflammatory and anti-itching activity. Studies have shown that oat alkaloids have multifunctional anti-inflammatory activity, including inhibition of keratinocyte nuclear factor NF-κB-α degradation directly related to inflammation, preventing phosphorylation of p65 protein subunit on nuclear factor NF-κB, thereby blocking the process of breaking cell inflammation; reducing the incidence of inflammatory immune response and skin neurodermatitis. Oat alkaloids inhibit TNF-alpha and induce activity of NF-kappa B degrading enzymes, reduce inflammatory factors and lead to the release of atopic dermatitis IL-8. At a low concentration of 30 ppm, oat alkaloids can greatly reduce the number of itching from contact dermatitis and neurodermatitis. The above evidence indicates that oat alkaloids have potent anti-inflammatory and anti-itch properties and are the potent non-steroidal anti-inflammatory and anti-itching natural ingredient with a potency comparable to hydrocortisone without any side effects of steroid hormones.
Tranilast is a drug very similar to the structure of dihydroolaline alkaloids and has powerful effects on: anti-inflammatory, anti-allergic, anti-irritation, fast anti-itching, antihistamine, immunomodulation, anti-fibrosis (anti-scarring), anti-erythema.
NanoSmooth can exert multiple effects such as antihistamine, anti-oxidation, anti-irritant, anti-inflammatory, and erythema and especially good at relieving sensitive skin, itching, irritation, redness, etc. The recommended dosage range from 0.5% to 5.0%.
Dihydrotomatine alkaloids and Tranilast structure
NanoSmooth can effectively suppress itching
NanoSmooth can effectively reduce erythema
NanoSmooth can effectively inhibit contact dermatitis
NanoSmooth can effectively inhibit contact dermatitis
NanoSmooth developed by nanoChaneel Delivery System（NDS）, completely solves the solubility problem of biopolyphenols and dihydrotomatine alkaloids. The active substances are stably encapsulated in nanocarriers, which are convenient for application, difficult to precipitate, and can significantly increase absorption efficiency and bioavailability.
Use : Adding at the low temperature stage, recommended dosage: 0.5-5.0%.
Storage: Keep it away from light at a temperature below 25℃.
NanoActive FA
NanoActive FA is a novel ferulic acid nanoliposome preparation (NanoLiposomal AA).
Product Name: Nano Liposomal Ferulic Acid; Nanoactive Ferulic Acid; BioaActive Ferulic Acid; BioActive FA; NanoActive FA; Soluble Ferulic Acid
CAS: 1135-24-6
Description: Ferulic acid is an organic acid isolated from Ferula foetida regel in 1866. Ferulic acid is an intercellular adhesive that binds the polysaccharides among cells to make the skin firm and elastic. Ferulic acid survives in the blood longer than L-C and is one of the ultimate anti-oxidant warriors. Ferulic acid is a fat-soluble antioxidant. Compared with vitamin E, ferulic acid has a better effect on removing fat-soluble free radicals. The content of ferulic acid is high in Chinese herbal medicines such as Ferula foetida regel, Angelica sinensis, Ligusticum wallichii, Cimicifuga foetida, and seeds of wild jujubes, and it is an active ingredient in these traditional Chinese medicines. It is effective in eliminating free radicals, anti-thrombus, anti-bacteria, anti-inflammation, inhibiting tumor, preventing hypertension, and heart diseases, enhancing the vitality of sperm as well as other health functions and protecting the skin.
Ferula foetida regel Ferulic acid
Features
- NanoActive FA uses FDA GRAS (Generally Recognized as Safe) materials so it is highly safe.
- NanoActive FA has a good stability towards heat, pH and shearing, so it is easy to use.
- NanoActive FA greatly improves the stability and bioavailability of ferulic acid.
- NanoActive FA improves the stability and absorption of other actives in the product.
- NanoActive FA is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.
Efficacy
- Firming: Combine the polysaccharides among cells to make your skin firmer (sagging eyelids, skin slackness after weight loss and pregnancy)
- Anti-aging: Confront free radicals (fat-soluble antioxidants)
- Whitening and evening skin tone: Absorb UVB and inhibit the formation of melanin (whitening by preventing tyrosinase synthesis of melanin through competitive inhibiting method)
Use:Add this product at room temperature and heat it to above 40 °C to speed up its dissolution. Recommended dosage: 1-5%. It works better with products such as Nano Vitamin C and Nano Vitamin E.
Storage: Keep it away from light at a temperature below 25℃.
Experimental proof
Black Cell Producing Effect of Ferulic Acid
Inhibiting Effect of Ferulic Acid against Tyrosinase Activity
Effect of Ferulic Acid on Skin Tone
Effect of Ferulic Acid on Hair
NanoActive phytosterol
NanoActive phytosterol is a new phytosterol nanoliposome preparation (NanoLiposomal phytosterol).
Product Name: Nano Liposomal Phytosterosl; Nanoactive PHYTOSTEROLS; BioaActive PHYTOSTEROLS; Soluble PHYTOSTEROLS CAS: 68441-03-2
Description: Phytosterol is a kind of substance with cyclopentane perhydrophenanthrene (also known as steroid nucleus) as its frame. It is similar in structure to animal sterols such as cholesterol, and is in free or binding state in nature. Known as the “key to life” and widely found in plants, phytosterol is a kind of natural physiologically active substances beneficial to humans. It can inhibit the cholesterol absorption of humans, promote the degradation and metabolism of cholesterol, inhibit the biosynthesis of cholesterol, etc., and has been found to have the function of inhibiting cardiovascular diseases in animal studies. Also, it is effective in anti-cancer, anti-tumor, anti-inflammatory, improving immunity, regulating growth, anti-virus, anti-oxidation, etc. In recent years, it has been proved that phytosterol has skincare effects such as anti-inflammatory, anti-irritation, moisturizing and anti-wrinkle. However, its poor solubility in water and oil, and demulsification when added in the formulation limit the application in cosmetics. The NanoActive phytosterol, developed with the nano-transmission system (NDS), has a particle size of less than 30nm, which solves the problems of solubility and enables phytosterol to be stably encapsulated in nano-carriers, thus greatly improving absorption efficiency and bioavailability.
Main component structure of phytosterol
Cholesterol is an important component of the epidermal layer of skin and plays an important role in maintaining skin health, but direct application of cholesterol to the skin can cause acne and inflammation. Phytosterol has a structure similar to cholesterol, so it can be used in skincare cosmetics to replace cholesterol. Phytosterol also has a similar effect to cholesterol on skin, which can increase skin elasticity and resist wrinkles, and help restore harmed skin. Compared with cholesterol, phytosterol is featured with the functions of anti-oxidation, anti-inflammation, anti-irritation, etc. Recently, German studies have further discovered that (Hautarzt. 2008 Jul; 59(7): 557-62.) phytosterol can effectively inhibit the expression of the collagen-degraded matrix metalloproteins (MMPs), block the decreased synthetic expression of collagen COL1A1 and COL1A2 induced by UV irritation, and even promote collagen expression. Therefore, it has a good moisturizing and anti-wrinkle effect and is an ideal anti-aging active substance. With high permeability to skin, phytosterol can maintain the moisture on the surface of your skin, promote skin metabolism, inhibit skin inflammation, prevent sunburn erythema, skin aging, facilitate hair growth, and nourish hair.
Phytosterol completely inhibits sunburn cell production (MED: minimum erythema dose, UV units)
Use:Add it at room temperature. You may heat it to above 40 °C to speed up its dissolution; recommended dosage: 1-5%. It works better with products such as nano vitamin A and ceramide.
Storage: Keep it away from light at a temperature below 25℃.
Nano Organic Acid Preservative (Bioactive NanoGuard)
Bioactive NanoGuard is a new type of organic acid preservative nano liposome preparation (NanoLiposomal NanoGuard).
Product Name: Nano Liposomal Bioactive NanoGuard; Nanoactive Bioactive NanoGuard; Bioactive NanoGuard
CAS: 65-85-0, 110-44-1
This product is a new safe and mild organic acid preservative prepared by specific nano-encapsulation technology with organic acids such as benzoic acid and sorbic acid as active materials. It can be used for anti-corrosion of organic certified products and natural cosmetics. The unique nanotechnology overcomes the high pH dependence of organic acid preservatives, with an applicable pH up to 7.0. Benzoic acid and sorbic acid are both recognised by ECOCERT as preservatives for organic certified cosmetics. Europe – Up to 2% used in rinse-off and leave-on products, US – benzoic acid can be used in both rinse-off and leave-on products. Japan – In finished products, the maximum allowable amount of benzoic acid and its sodium salt is 1%. It can be used in eye serum and other products with high irritability as it is non-irritating.
Chemical structure:
benzoic acid
Sorbic acid
Sorbic acid and benzoic acid have long been widely used as preservatives in food, pharmaceutical and daily chemical products. Although their safety and effectiveness are fully recognized, they are highly dependent on the pH of the system. When the pH is higher than 4.0, its antibacterial effect was significantly lowered; when the pH is higher than 6.0, it almost loses its antibacterial activity. The new preservative developed by nano-encapsulation technology effectively solves the problem of pH dependence of benzoic acid and sorbic acid. It works effectively as an antiseptic within the range of pH 1.0-7.0, and can be widely applied to various products. The product has good solubility (the solubility in water is 20-30 times that of benzoic acid and sorbic acid, both oil-soluble and water-soluble), good thermal, pH stability and compatibility, and can be widely applied to various products.
This product effectively overcomes pH dependence
NanoActive Lutein
NanoActive Lutein is a new lutein nano liposome preparation (NanoLiposomal Lutein).
Product Name: Nano Liposomal Lutein; Nanoactive Lutein; BioaActive Lutein; Soluble Lutein CAS: 127-40-2
Description: Lutein, also known as plant lutein, coexists with zeaxanthin in nature. It is the main pigment that forms the macular area of the human eye. Human eyes contain high amounts of lutein which can only be supplemented by the intake of lutein as human body can not produce this element by itself. Without lutein, human will lose eyesight. A natural carotenoid found in vegetables and fruits, Lutein is a good antioxidant that protects cells in human body from the damage of free radical. Lutein is good for vision health as it can resist sunlight, blue light in computer and cellphone screens, relieve eye fatigue, sore eyes, tears, myopia, and prevent eye diseases such as cataracts and maculopathy. The skin is the only barrier between internal and external environment for human body. Lutein also plays a role in filtering blue light and strong anti-oxidation for the skin, greatly avoiding the damage of light to skin cells and preventing various kinds of skin disease caused by intense light stimulation. The high-energy blue light from electronic screen inhibits the generation of melatonin, penetrates deep into the skin layer, damages collagen, hyaluronic acid and elastin, accelerating skin aging, and may cause bad skin conditions such as enlarged pores, dark circles and hemorrhoids. Functioning as blue light filter and anti-oxidation agent, Lutein is the most effective biological actives that protects the skin from high-energy blue light. NanoActive Lutein developed by new nano-transfer technology solves lutein’s problems including low solubility, low stability and tendency to lose or change color, which make it hard to apply in skin care products. It is a multi-effect skincare actives that is anti-blue light, anti-oxidation and anti-aging. Lutein also performs well in skincare products, eliminating ubiquitous blue light and free radicals.
- Effectively inhibits the formation of harmful free radicals, slows down skin aging, and facilitates bright and elastic skin;
- Absorbs large amounts of daylight, computer light, and office lighting to protect skin against damage caused by UVA/UVB and blue light.
A type of carotenoid, Lutein is a natural colorant or pigment. It is found in dark green leafy plants such as spinach, various fruits and corn. The egg yolk also contains lutein. Lutein nutritionally supports human eyes and skin. The eye is the only organ in our body that receives external light stimuli, while the skin is the only one that is directly exposed to the external environment. As an antioxidant, Lutein can eliminate free radicals in human body or reduce its damage. Excessive free radicals can cause various chronic diseases. Lutein can improve vision and also ensure the health of the eye by reducing the risk of macular degeneration. Lutein can increase the skin’s antioxidant capacity and help prevent free radical damage.
Lutein structure
Mobile phones and computers are now indispensable in urbanites’ lives. Smartphones and computers can cause the same damage to our skin as ultraviolet rays from the sun because the blue light emitted by the screen can inhibit melatonin generation and penetrate deep into the skin layer, damaging collagen, hyaluronic acid and elastin, and accelerating skin aging. It can also cause skin problems such as enlarged pores, dark circles, and hemorrhoids.
Lutein is the most effective active against blue light damage. It can filter out up to 90% of high-energy blue light from the visible spectrum. Blue light is different from the commonly known ultraviolet A and ultraviolet B in the invisible light spectrum. Blue light can trigger oxidation reactions and cause potential free radical damage for human organs such as eyes and the skin that are exposed to both indoor light as well as sunlight.
Lutein mechanism
The antioxidant activity of natural lutein can protect skin cells, by preventing oxidation and free radicals from the very beginning, and working effectively to whiten the skin, remove freckle and wrinkle, moisturize, increase skin elasticity, glossiness and smoothness, and delay skin aging.
As it is a fat-soluble compound, Lutein is hard to be absorbed by the skin with ordinary emulsions. The lutein nanoactive material with a particle size of less than 30 nm developed by the nano-transport system (NDS)completelysolves the solubility and stability problems of lutein, allowing lutein to be stably encapsulated in the nanocarrier so that it hugely improves absorption efficiencyandbio-availability and becomes suitable for aqueous agent system.
Product features ：
- NanoActive Lutein uses FDA GRAS grade materials for higher safety
- NanoActive Lutein is stable to heat, pH, and cuts, so it is convenient to use
- NanoActive Lutein greatly enhances the stability and bioavailability of lutein
- NanoActive Lutein improves the stability and absorption of other actives in the product
- NanoActive Lutein is 100% water soluble and has a wide range of applications
Product Effects:
- NanoActive Lutein protects the skin from blue light, increases the antioxidant effect of skin cells, and reduces the damage of free radicals to the skin;
- NanoActive Lutein is an active ingredient that works well to remove wrinkles, whiten the skin, anti-aging, moisturize and increase skin elasticity.
Product use: Add under low temperature; recommended dosage: 1-5%.
Product storage: keep away from light at a temperature below 25°C.