NanoActive Sulfur PRODUCT DATA SHEET

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Advanced Nano-Encapsulated Bio-Derived Sulfur for Multi-Targeted Skin Solutions

Company: PuriPharm Co. Ltd.

Website: www.PuriActives.com

Contact: Service@puripharm.com | Tel: 13167223168

1. PRODUCT OVERVIEW

Sulfur is a naturally occurring nonmetal with a long-standing dermatological history of effectively treating various skin disorders. However, traditional sulfur applications are severely limited by poor water solubility, large particle sizes (2–5 μm), low bioavailability, and formulation challenges.

NanoActive Sulfur, developed by PuriPharm Co. Ltd., is a cutting-edge active ingredient that utilizes a proprietary Nano-Delivery System (NDS). By stably encapsulating highly active bio-derived sulfur into sub-30 nm lipid-based nanocarriers, it completely resolves traditional solubility and aesthetic issues. The result is a highly bioavailable, transparent, and universally compatible active that regulates sebum, reduces inflammation, and offers potent antibacterial properties for acne and scalp care.

2. COMPOSITION & INCI INFORMATION

NanoActive Sulfur is formulated using a specialized biomimetic lipid matrix designed for optimal trans-epidermal delivery. It is strictly free from added preservatives and antioxidants.

Composition Range Table:

3. TECHNICAL SPECIFICATIONS

4. TECHNOLOGY HIGHLIGHTS: THE NDS ADVANTAGE

  • Ultra-Fine Particle Size (< 30 nm): Significantly increases the specific surface area and interaction with keratinocytes, ensuring superior skin penetration and biological activity compared to traditional 2-5 μm sulfur.
  • Exceptional Formulation Flexibility: The unique hydrophilic-lipophilic structural modification allows NanoActive Sulfur to be seamlessly incorporated into lotions, creams, clear gels, and water-based formulas without precipitation.
  • Aesthetic Superiority: Unlike traditional sulfur, which is chalky and difficult to suspend, NanoActive Sulfur maintains optical clarity (forming a transparent solution at typical usage levels), leaving no residue and enabling elegant cosmetic formulations.
  • High Stability & Bioavailability: The robust phospholipid-based nanocarrier prevents aggregation, protects the active payload, and ensures targeted delivery to the sebaceous glands and follicles.

5. KEY COSMETIC BENEFITS & MECHANISM OF ACTION

A. Comprehensive Sebum Regulation & Keratolysis

Excessive sebum accumulation leads to enlarged pores, follicular blockage, and inflammation. NanoActive Sulfur effectively removes surface lipids, softens the epidermis, and dissolves keratin plugs.

●Mechanism:At low concentrations, sulfur exerts a keratoplastic effect, promoting normal keratinization. At higher concentrations, it becomes keratolytic, reacting with cysteine to form cystine and hydrogen sulfide (), which safely disrupts excess keratin and clears clogged pores.

B. Targeted Antibacterial & Antifungal Action

NanoActive Sulfur acts as a potent purifying agent and helps rebalance the skin microbiome.

●Mechanism: Skin bacteria and keratinocytes convert sulfur into pentathionic acid (), a compound highly toxic to fungi and pathogenic bacteria. The keratolytic action further helps detach microorganisms from the stratum corneum.

●Microbiological Efficacy (In Vitro):

○P. aeruginosa: MIC = 1.95 μg/mL | MBC = 1000 μg/mL

○S. aureus: MIC = 125 μg/mL

○E. coli: MIC = 500 μg/mL

C. Powerful Anti-Inflammatory & Soothing Properties

Severe oxidative stress depletes intracellular Glutathione (GSH), triggering inflammatory cascades.

●Mechanism:NanoActive Sulfur supports cellular antioxidant defenses by promoting GSH synthesis.

●Efficacy:Exerts a strong, dose-dependent reduction in the expression of key pro-inflammatory cytokines. Clinical evaluations (ELISA) show that concentrations between 0.1% and 0.4% significantly downregulate the protein expression ofIL-1β,IL-6, and TNF-α.

D. Clinically Proven Acne Treatment

Inin-vivoassessments, formulations containing NanoActive Sulfur demonstrated visible improvement in acne-prone skin profiles. A 60-day application of 0.2% active showed a significant reduction in inflammatory lesions and post-acne erythema, making it an ideal candidate for long-term acne management.

6. RECOMMENDED APPLICATIONS

NanoActive Sulfur is highly versatile and is recommended for the following cosmetic product categories:

  • Acne & Blemish Control: Spot treatments, anti-acne serums, and purifying toners.
  • Sebum Control & Pore Refining: Mattifying lotions, oil-control powders, and deep-cleansing masks.
  • Brightening & Spot-Fading: Post-inflammatory hyperpigmentation (PIH) correctors.
  • Scalp Care: Anti-dandruff shampoos and scalp-soothing serums (seborrheic dermatitis support).
  • Soothing & Repair: Products targeting sensitized, inflamed, or compromised skin barriers.

7. FORMULATION GUIDANCE

  • Suggested Use Level: 0.1% – 5.0% (Depending on target efficacy: low doses for daily maintenance/anti-inflammation; higher doses for targeted spot treatments).
  • Solubility: Amphiphilic nature allows it to be easily added to either the aqueous phase or the final emulsion at room temperature or gently heated conditions.
  • Compatibility: Compatible with a wide range of cosmetic ingredients, including traditional water-based and oil-based systems. Does not cause phase separation.

8. STORAGE, HANDLING & PACKAGING

  • Storage: Store in the original, unopened container at 4°C to 25°C. Protect from direct sunlight and maintain in a dry environment.
  • Shelf Life: 12 months under specified storage conditions.
  • Packaging: Supplied in standard industrial plastic containers.

Disclaimer: The information contained in this document is provided in good faith and is based on our current knowledge and internal testing. Formulators are responsible for ensuring the final cosmetic product’s stability, safety, and regulatory compliance in their respective target markets.

PuriPharm Co. Ltd. | Advanced Active Ingredients

NanoActive Sulfur

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Introduction

Sulfur is a yellow nonmetal widely distributed throughout the earth and has long been used as an effective treatment for various skin disorders. Its activity depends on the interaction between sulfur particles and keratinocytes: the smaller the particles, the larger the contact area and the better the efficacy. Bio-derived sulfur formed by the bacterial oxidation of sulfides into elemental sulfur shows better spreadability on the skin and higher activity.

NanoActive Sulfur, developed through a nano-delivery system, effectively regulates sebum secretion and helps treat acne and dandruff, while also providing strong antibacterial and anti-inflammatory activity.

Sebum Regulation

Excessive sebum secretion accumulates in follicles, enlarges pores, causes follicular blockage, and may even trigger inflammation.

NanoActive Sulfur effectively removes excess surface oil and helps soften the epidermis. It can also dissolve keratin and relieve skin imbalance caused by overactive oil secretion. In addition, it helps improve acne, pimples, and seborrheic dermatitis associated with overactive sebaceous glands.

Keratolytic Effect

Cystine is a major component of the stratum corneum. At low concentrations, sulfur promotes normal keratinization through its keratoplastic activity. At high concentrations, the same reaction produces a keratolytic effect because hydrogen sulfide disrupts keratin, and sufficient accumulation can dissolve the stratum corneum.

Therefore, NanoActive Sulfur is recommended for cosmetic formulations designed to regulate sebum secretion.

Antibacterial Action

The antibacterial action of sulfur depends on its conversion into pentathionic acid (H₂S₅O₆), a compound toxic to fungi. Hydrogen sulfide may also contribute to this activity. Through the action of skin bacteria and keratin-forming cells, sulfur can be converted into pentathionic acid. In addition, sulfur’s keratolytic activity may help separate fungi from the stratum corneum.

Therefore, NanoActive Sulfur is recommended for cosmetic formulations with purifying and preservative functions.

Pentathionic Acid Activity

Anti-inflammatory Action

Glutathione (GSH) is the most important cellular antioxidant. It exists in the reduced thiol form (GSH) and the oxidized disulfide form (GSSG), and undergoes thiol-disulfide exchange catalyzed by thiol transferases. Severe oxidative stress depletes intracellular GSH.

NanoActive Sulfur can promote GSH synthesis while reducing pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α, delivering a strong anti-inflammatory effect.

Inflammatory Factor Reduction

Inflammatory Factor Reduction

The protein expression levels of TNF-α, IL-1β, and IL-6 were measured by ELISA.

Compared with the control group, NanoActive Sulfur reduced the expression of TNF-α, IL-1β, and IL-6 in a dose-dependent manner.

NanoActive Sulfur in Acne Treatment

5% NanoActive Sulfur 2 months

Visible improvement in acne appearance after continuous use.

Challenges in Sulfur Applications

Advantages of NanoActive Sulfur

NanoActive Sulfur has a unique chemical structure (linear and hydrophilic), making it easier to formulate, easier to combine with other ingredients, and easier to absorb.

Nano-delivery System

NanoActive Sulfur developed with a nano-delivery system (NDS) has a particle size below 30 nm. It completely solves sulfur solubility issues by stably encapsulating sulfur inside nano-carriers, greatly improving absorption efficiency and bioavailability.

NanoActive Sulfur

Applications

Market Cases

Puri-Xyl THE 3D HYDRATION EXPERT

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The Challenge: Dehydrated Skin

Signs of Imbalance

Environmental stress and aging disrupt the skin’s natural water balance, leading to:

  • Visual Dryness:Flaking and dullness.
  • Physical Discomfort:Tightness and roughness.
  • Structural Weakness:Compromised barrier function.

The Goal: To restore equilibrium between water reserves and water loss.

Introducing Puri-Xyl

Natural Sugar Technology:

Puri-Xylis auniquecomplex of natural sugars derived fromWheat andCorn. It represents a green chemistry approach to skin hydration.

INCI Name: Xylitylglucoside,Anhydroxylitol, Xylitol

Key Attributes: Preservative-free,Allergen-free, Non-GMO.

Green Synthesis & Structure

TheHydraconcept: 3D Hydration

Mechanism 1: Dermal Reserves

Mechanism 2: Barrier Function

Ceramide Synthesis: A healthy barrier relies on the “mortar” holding cells together. Puri-Xylsignificantly stimulates the synthesis ofCeramides 1 & 2.

The Result: This creates an “Anti-Dehydration Shield,” physically preventing water from evaporating and protecting against external aggressors.

Mechanism 3: Water Circulation

Aquaporins (AQP3): Puri-Xylupregulates Aquaporin-3, the dedicated water channels in cell membranes. This ensures active transport of water and glycerol from the dermis to the epidermis.

Tight Junctions: By reinforcing tight junctions, Puri-Xylensures that water flow is controlled and distributed evenly throughout the epidermal layers, maximizing hydration efficacy.

Clinical Evaluation Protocol

Deep Hydration Kinetics

Anti-Dehydration Shield

Skin Restructuring

Smoothing & Normalization

Puri-Xyl doesn’t just hydrate; it restructures the skin surface by normalizing the desquamation process.

+25% Improvement in desquamation (less flaking).

+30% Improvement in skin micro-relief (smoother texture).

Visual Result: Skin looks plump, healthy, and radiant.

Safety & Tolerance

Technical Profile

Versatile Applications

Puri-Xyl PRODUCT DATA SHEET

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PRODUCT DATA SHEET

Product Name: Puri-Xyl

Version: 2.0

Supplier: PuriPharm Co. Ltd.

1. PRODUCT OVERVIEW

Puri-Xyl is a moisturizing and restructuring complex derived from natural plant sugars. It is designed to harmonize the hydrous flow of the skin based on the “3D Hydration” concept, ensuring comprehensive hydration across all skin layers.

  • INCI Name: Xylitylglucoside, Anhydroxylitol, Xylitol
  • Product Category: Active Ingredient / Moisturizer
  • Origin: Plant-derived (Wheat & Corn)
  • Compliance: Preservative-free, Non-GMO, Allergen-free

2. KEY BENEFITS

Puri-Xyl optimizes the skin’s water flow, offering both immediate and long-term moisturizing benefits while reinforcing the skin barrier and improving surface texture.

  • Hydration Reservoir: Significantly boosts dermal water reserves (Glycosaminoglycans/GAGs).
  • Barrier Function: Stimulates ceramide synthesis to limit Trans-Epidermal Water Loss (TEWL).
  • Water Circulation: Optimizes the expression of Aquaporins to facilitate epidermal water flow.
  • Restructuring: Normalizes the desquamation process for smoother skin.
  • Visual Improvement: Reduces flaking/dryness and smooths micro-relief.

3. COMPOSITION

4. MECHANISM OF ACTION

Puri-Xyl acts on three levels of the skin:

1.Dermis (Reserves): Significantly increases the synthesis of Glycosaminoglycans (GAGs).

  • Chondroitin Sulfate: +183%
  • Hyaluronic Acid: +20% (Epidermis), +55% (Dermis)

2.Epidermis (Flow): Stimulates the expression ofAquaporin-3 (AQP3)to facilitate water and glycerol transport between cells; strengthens Tight Junctions.

3.Stratum Corneum (Barrier): Promotes the synthesis of Ceramides 1 and 2, reinforcing the intercellular lipid cement to create an “Anti-Dehydration Shield.”

5. EFFICACY DATA

In-Vivo Study: 25 volunteers with dry skin applied a lotion containing 3% Puri-Xyl twice daily for 30 days.

●Anti-Dehydration Shield: After 30 days, Trans-Epidermal Water Loss (TEWL) was significantly reduced by-13%.

●Hydration Kinetics:

○24 Hours:Immediate barrier reinforcement observed.

○8 Days:Visible improvement in hydration.

○30 Days:Maximum hydration effect achieved.

●Skin Restructuring:

○Desquamation Improvement:+25%(Reduced flaking)

○Skin Micro-relief:+30%(Smoother texture)

6. PHYSICAL PROPERTIES

  • Appearance: Liquid
  • Color: Colorless to pale yellow
  • Odor: Characteristic, faint
  • Solubility: Soluble in water, alcohol, and glycols
  • Shelf Life:24 months

7. FORMULATION GUIDELINES

  • Recommended Dosage:1.5% – 5.0% (Clinically tested at 3%)
  • Incorporation: Can be added at any stage of the formulation process (aqueous phase or end).
  • pH Stability:Stable over a wide pH range (pH 3.0 – 10.0).
  • Thermal Stability:Excellent; can withstand heating up to 80°C.
  • Compatibility: No known incompatibilities; compatible with high electrolyte concentrations.

8. SAFETY & TOXICOLOGY

  • Skin Tolerance:Excellent (48-hour Patch Test).
  • Ocular Tolerance:Good (HET-CAM Test).
  • Sensitization: Non-sensitizing.
  • Mutagenicity: Non-mutagenic (Ames Test).

9. APPLICATIONS

Suitable for various cosmetic formulations:

  • Face Care: Daily moisturizers, anti-aging serums, night creams.
  • Body Care: Body lotions, hand creams, shower gels (reduces surfactant irritation).
  • Hair Care:Scalp hydration treatments, shampoos, conditioners.
  • Specific Care: Products for dry/sensitive skin, after-sun care.

Disclaimer: The information contained in this data sheet is based on our current knowledge. It is the user’s responsibility to verify the suitability of the product for their specific application.

NanoActive r-RETINOATE PRODUCT DATA SHEET

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PRODUCT DATA SHEET

Product Name: NanoActive r-RETINOATE

Manufacturer: PuriPharm Co., Ltd.

Awards: 2019 Ringier Technology Innovation Award (Personal Care)

1. Product Overview

NanoActive r-RETINOATEis a next-generation, high-performance Vitamin A derivative engineered to overcome the traditional limitations of retinoid application in cosmetic science. Utilizing a proprietary 20–30 nm nano-encapsulation delivery system, this bioactive ingredient combines exceptional anti-aging efficacy with unprecedented stability and skin tolerability.

Formed by esterifying the hydroxyl group of retinol with retinoic acid, Retinyl Retinoate retains the bioactivity of both precursor molecules. It delivers up to 8x the activity of standard retinol while eliminating the characteristic irritation and photosensitivity. Crucially, its distinctive blue-light absorption profile and high photostability make it a breakthrough retinoid that is completely safe and effective for daytime application.

2. Chemical Description & Composition

  • INCI Name: Retinyl Retinoate, Ascorbic Acid (Vitamin C), Phospholipids, Caprylic/Capric Triglyceride, Glycerin, Water
  • Product Type: Nano-encapsulated Bioactive System
  • Active Concentration: Available in 1.0% or 5.0% Retinyl Retinoate specifications

3. Physical & Chemical Properties

  • Appearance: Yellow-orange viscous liquid
  • Odor: Characteristic
  • pH Value: 5.0 – 8.0
  • Solubility: Amphiphilic (compatible with both water and oil phases)
  • Photostability: Excellent (not light-sensitive; suitable for day-care formulations)

4. Platform Technology & Delivery System

PuriPharm’s advanced nano-delivery platform transforms how retinoids interact with the skin structure:

  • Targeted Follicular Absorption: The 20–30 nm particle size allows the nanocarriers to accumulate efficiently within the hair follicle pathway. This creates a deep-skin “follicular reservoir” where actives can be retained rather than merely remaining on the skin’s surface.
  • Sustained Release Kinetics: Once deposited in the appendages, the nano-emulsion structure facilitates a controlled, slow-release mechanism that extends the activity window for more than 10 days, ensuring long-lasting efficacy without overwhelming the skin barrier.
  • Unique Occlusion Effect: Nano-sized lipid carriers create a highly uniform, tight surface film, increasing residence time and local deposition of the active compound.

5. Mechanism of Action: The One-Step Advantage

Traditional retinol formulations require a slow, three-step metabolic conversion (Retinyl Esters → Retinol → Retinal → Retinoic Acid) to become biologically active.

NanoActive r-RETINOATE features a direct “One-Step Conversion.”As a direct precursor, it is highly efficient and minimizes intermediate degradation.

Biocompatibility & Cytotoxicity:

In vitro data demonstrates that Retinyl Retinoate possesses significantly lower cytotoxicity compared to standard retinol. The IC50 of retinol is 25 μM, whereas the IC50 of NanoActive r-RETINOATE is 40 μM (an approximately 60% improvement in cellular tolerability), showcasing its ability to provide intense rejuvenation without the peeling, erythema, and barrier compromise associated with traditional Vitamin A.

6. Proven Cosmetic Benefits & Efficacy Data

A. Profound Anti-Aging & UV Repair (12-Week Clinical Study)

A controlled clinical trial comparing 0.06% Retinyl Retinoate (Group A) against 0.075% Retinol (Group B) applied twice daily demonstrated superior anti-aging performance:

  • Elasticity Improvement: 90.9% of Group A subjects reported noticeable periocular elasticity improvement (vs. 81.8% in Group B).
  • Photodamage Reversal: Group A exhibited an 8.61% measurable improvement in photodamage repair (vs. 7.43% in Group B).
  • Longevity of Efficacy: NanoActive r-RETINOATE showed a significantly weaker “diminishing marginal effect,” meaning anti-wrinkle benefits continued to compound and remain highly visible even over long-term (1 year+) usage.

B. Hyaluronic Acid (HA) Expression

In vivotesting on epidermal and dermal tissues (HABP staining) confirms that NanoActive r-RETINOATE significantly upregulates endogenous mucopolysaccharide (hyaluronic acid) synthesis, heavily outperforming both standard retinol and retinoic acid.

C. Multi-Pathway Skin Enhancement

  • Structural Integrity: Inhibits UV-induced Matrix Metalloproteinases (MMP) activity, reducing the breakdown of endogenous proteins, protecting elastic fibers, and promoting collagen synthesis.
  • Tone & Clarity: Works synergistically with its Vitamin C component to inhibit tyrosinase, accelerate melanin metabolism, and reduce visible redness.
  • Texture & Blemishes: Promotes healthy keratinocyte activity, increases epidermal thickness, and functions via multiple mechanisms to clear blemishes and accelerate the repair of acne marks.

7. Formulation Guidance

NanoActive r-RETINOATE is engineered for formulation elegance and versatility:

  • Recommended Use Level: 1.0% – 5.0%
  • Optimum pH Range: 3.0 – 6.5
  • Processing: Simple to formulate. Add to the system at the final stage of manufacturing (post-emulsification, during the cooling phase) to protect the nanostructure.
  • Compatibility: Highly compatible with a wide range of cosmetic matrices. Works exceptionally well in synergy with additional Hyaluronic Acid, Vitamin C, and biocomposite polysaccharides (e.g., hydrolyzed myrtle) for accelerated wrinkle-reduction claims.

8. Recommended Applications

  • Daytime Anti-Aging Care: Day creams, lotions, and serums targeting fine lines, leveraging its unique photostability.
  • Intensive Photodamage Repair: Post-sun recovery formulations and deep wrinkle repair treatments.
  • Advanced Brightening: Radiance serums addressing hyperpigmentation and uneven skin tone (pairs perfectly with brightening regimens).
  • Acne & Barrier Repair: Clarifying formulations aimed at treating blemishes, repairing acne marks, and thickening the epidermal layer.

Disclaimer: This document is provided for informational and technical support purposes only, based on PuriPharm Co., Ltd. research and development data. Formulators are responsible for conducting full stability, compatibility, and safety evaluations of their finished cosmetic products. PuriPharm Co., Ltd. makes no warranties regarding the specific outcomes of end-user formulations.

NanoActive r-RETINOATE

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NanoActive r-RETINOATE

8× retinol activity

Photostable • Non-irritating

A next-generation vitamin A derivative

Company Overview

PuriPharm Biopharmaceutical Technology Co., Ltd.

Delivering Beauty • Creating Value

Focused on the research and development of bioactives.

  • Specialized in the development of bioactive materials and functional ingredient systems.
  • Combines scientific delivery technology with application-oriented product design.
  • Dedicated to high-performance ingredients for beauty and personal care.

Nano Delivery Technology

  • One of the most widely studied and applied new formulation technologies.
  • Applicable across pharmaceuticals, foods, cosmetics and other fields.
  • Nano-bioactives are new products developed using nanodelivery systems.
  • Improves solubility, stability, irritation profile and odor while offering unique biological effects.

Fourth-Generation (4G) Cosmetic Ingredients

  • Clearly defined ingredients and content
  • Clearly defined targets
  • Clear mechanism of action
  • Formulations designed to preserve bioactivity
  • Good solubility
  • Stable and non-discoloring
  • Easy to absorb

A perfect combination of traditional medicine, modern biotechnology and nanotechnology.

Unique Occlusion Effect

Follicular Targeted Absorption

  • Nanocarriers accumulate efficiently around the hair follicle pathway.
  • This supports targeted delivery into deep skin appendages where actives can be retained and released.

Key takeaway：Hair follicles provide an efficient access route for targeted nano-delivery.

Smaller Particles Penetrate Deeper

and in Greater Amounts

  • Reduced particle size increases penetration depth in skin.
  • Smaller particles also increase the delivered amount of active ingredient.

The smaller the carrier, the deeper the penetration and the higher the delivery amount.

Follicular Reservoir Enables Slow Release for

More Than 10 Days

  • Hair follicles act as a storage reservoir for the active ingredient.
  • The active can be released gradually for more than 10 days after deposition.
  • This supports long-lasting efficacy with sustained local availability.

Long-lasting delivery：Slow release extends the activity window after follicular deposition.

Vitamin A：

A core scientific foundation for the product story

Functions of Vitamin A in the Human Body

  • Supports vision and visual signaling.
  • Contributes to growth, reproduction and immune support.
  • Involved in antioxidant defense, cell differentiation and gene transcription.

Vitamin A and Nobel Prizes

Vitamin A Is the Gold Standard in Anti-Aging Skincare

Common Vitamin A Actives Used in Skincare

Conversion to Retinoic Acid in Vivo

Why It Won the Award

2019 Ringier Technology Innovation Award

  • Vitamin A derivative suitable for daytime use
  • Safe and low irritation
  • Nano-encapsulation protects the active ingredient
  • A breakthrough and a new technical approach for retinoid raw materials

A distinctive retinoid concept that balances efficacy, stability and tolerability.

Unique Absorption Spectrum

  • Distinctive absorption profile
  • Efficient blue-light absorption
  • Good photostability

Product Introduction

  • Retinyl retinoate is obtained by esterifying the hydroxyl group of retinol with retinoic acid, while avoiding the application limits of retinol and retinoic acid in cosmetics.
  • NanoActive r-RETINOATE has an encapsulated particle size of 20–30 nm. This nanoemulsion size keeps the active stably suspended in the nanocarrier, enhances skin penetration and helps control the release rate.

Particle size：20–30 nm nano-encapsulation；

Delivery effect：Stable suspension, enhanced penetration and controlled release

Product Introduction

Skincare Benefits of Retinyl Retinoate

Efficacy Summary

Product Description

Formulation Guide

Suitable Products

Anti-aging products：

Maintains collagen in the dermis and helps prevent excessive collagen degradation.

When combined with hyaluronic acid and biocomposite polysaccharides (hydrolyzed myrtle), improvement in fine lines can be observed within one week.

Brightening products：

Works synergistically with vitamin C to inhibit tyrosinase, promote metabolism and accelerate fading of melanin.

The source deck notes that pairing with vitamin C is also effective for acne-prone skin.

Suitable Products

Sunscreen products：

Inhibits the UV-induced increase of MMP activity and helps protect elastic fibers and dermal collagen.

Improves wrinkles and fine lines caused by UV exposure.

Repair products：

Promotes endogenous hyaluronic acid synthesis and reduces skin TEWL.

Promotes keratinocyte activity and increases epidermal thickness, making the epidermis stronger.

NanoActive MN PRODUCT DATA SHEET

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Manufacturer: PuriPharm Co. Ltd.

1. Product Overview

NanoActive MN is an advanced, high-performance bioactive ingredient engineered specifically for premium skin and hair care formulations. Utilizing state-of-the-art nano-delivery technology, NanoActive MN features a specialized lipophilic tail that drastically improves skin penetration while minimizing the irritation and sensitization traditionally associated with unmodified nicotinic acid.

Once delivered into the skin, it undergoes targeted conversion into Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme that orchestrates cellular energy metabolism, DNA repair, and lipid synthesis, fundamentally reversing the age-related decline of skin and hair follicle vitality.

2. INCI & Chemical Information

  • INCI Name: Myristyl Nicotinate
  • Product Type: Nano-encapsulated Bioactive Agent

3. Technology Highlights

PuriPharm Co. Ltd. leverages proprietary core technologies to ensure maximum efficacy:

  • Nano Delivery System: Advanced nanotechnology ensures optimized bioavailability and targeted, deep-layer delivery of the active compound.
  • Enhanced Penetration: The lipophilic modification facilitates superior transepidermal transportation.
  • Targeted Action: Precisely targets local skin cells and hair follicles where esterase activity initiates the conversion process.
  • Improved Stability: Formulated to protect the active core, ensuring long-term shelf-life and robust compatibility within complex cosmetic matrices.

4. Mechanism of Action: The NAD+ Pathway

NAD+ levels natively decline by up to 50% by middle age, leading to compromised cellular repair and energy metabolism.

NanoActive MN effectively addresses this:

  1. Enzymatic Cleavage: Upon penetration, native skin esterases selectively cleave the lipophilic tail of NanoActive MN.
  2. Conversion: The molecule is efficiently converted into the active coenzyme NAD+ via cellular synthetic pathways.
  3. Cellular Optimization: The synthesized NAD+ directly fuels mitochondrial energy generation, upregulates barrier lipid synthesis, and supports genomic (DNA) repair, combating oxidative stress and cellular senescence.

5. Proven Cosmetic Benefits & Efficacy Data

NanoActive MN has demonstrated remarkable results across comprehensive clinical andin vitroevaluations:

A. Profound Skin Barrier Repair

  • Visual & Structural Improvement: Clinical studies demonstrate a 250% improvement in barrier function on facial skin and an 11% improvement on the forearm volar surface (at 5% use level).
  • Epidermal Fortification: Induces a highly significant 70% increase in epidermal thickness (compared to a 13% increase in the control group).
  • Tight Junction Enhancement: Upregulates ZO-1 protein expression (3.38-fold relative expression at 0.04 mg/mL), physically reinforcing the skin barrier.

B. Anti-Aging & Cellular Renewal

  • Accelerated Renewal: Safely accelerates skin cell renewal by reducing Dansyl turnover time and increasing Minimal Erythema Dose (MED) without inducing photosensitivity.
  • Antioxidant Capacity: Exhibits excellent DPPH radical scavenging ability (6.10% maximum clearance at 0.3125%).

C. Hair Follicle Vitality & Anti-Hair Loss

  • Scalp Energy: Converts to NAD+ within the scalp, enhancing cellular ATP, stimulating follicle cell renewal, and actively neutralizing oxidative stress.
  • Clinical Hair Improvement: Well-designed clinical trials confirm significant improvements in hair abundance, density, hair shaft thickness, and overall hair quality with zero reported adverse effects.

D. Synergistic Efficacy with Retinoids

  • Retinol Companion: When formulated alongside retinoic acid or its derivatives, NanoActive MN acts as a potent buffer—significantly reducing retinoid-induced irritation and Transepidermal Water Loss (TEWL) while amplifying overall anti-aging efficacy.

6. Formulation Guidance & Compatibility

NanoActive MN is designed for seamless integration into modern cosmetic chemistry.

  • Suggested Use Level: 0.2% – 5.0%
  • Suitable Formulations: O/W and W/O Emulsion systems, Creams, Lotions, Serums, Essential Oils, Massage Oils, and Cleansing products.
  • Ingredient Compatibility: Exhibits excellent compatibility with a wide array of cosmetic raw materials including UV filters, emollients, humectants, natural oils, potent antioxidants, emulsifiers, thickeners, and retinoids. Minimal degradation is observed even in complex formulation matrices.

7. Recommended Applications

  • Advanced Facial Care: Anti-aging creams, barrier-repair lotions, and high-potency cellular regeneration serums.
  • Eye Care: Non-irritating eye creams and serums targeting fine lines and delicate skin reinforcement.
  • Hair & Scalp Care: Anti-hair loss treatments, scalp energizing tonics, and hair density serums.
  • Color Cosmetics: Functional lipsticks, lip glosses, eyeliners, and mascaras requiring bioactive support.

8. Storage, Stability, and Handling

  • Long-Term Stability: Demonstrates exceptional stability; viable for 24 months at room temperature in various formulations. Withstands accelerated stability testing (3 months at 40°C).
  • Storage Conditions: Store in a cool, dry environment between 4°C and 25°C. Protect from direct sunlight and moisture. Keep the original container tightly sealed when not in use.

Disclaimer:The information contained in this document is provided in good faith and is based on our current laboratory data and technical knowledge. It is intended for informational purposes only. Formulators are responsible for ensuring the stability, safety, and legal compliance of their final consumer products. PuriPharm Co. Ltd. makes no warranties, expressed or implied, regarding the use of this product.

NanoActive MN Advanced Bioactive Ingredient for Skin and Hair Care

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Product Overview

INCI Name

The INCI name is MyristylNicotinate, which is the standardized name in the cosmetic industry.

Product Type

It is an advanced bioactive ingredient specifically designed for skin and hair care products.

Key Feature

It can convert to NAD + in skin cells, improving penetration and reducing irritation compared to regular nicotinic acid.

Features & Applications

Applications

Mechanism of Action

The NAD + pathways and conversion process ofNanoActiveMN

NAD+ Pathways

NAD+ Importance

NAD + is essential for energy generation in mitochondria, lipid synthesis, DNA damage repair, and maintaining mitochondrial function and telomere length.

NAD+ Synthesis Pathways

There are three main pathways: the de novo pathway starting from tryptophan, the Preiss – Handler pathway using nicotinic acid, and the salvage pathway recycling NAD + metabolites.

NAD+ and Skin Health

NAD + is critical for cellular repair, energy metabolism, and combating age – related decline in skin. Its levels decrease by 50% by middle age.

NanoActiveMN Conversion

Efficacy Data

Barrier Repair：

Efficacy data on skin barrier repair

Anti – aging & Antioxidant

1. DPPH Radical Scavenging

The maximum clearance is 6.10% at a concentration of 0.3125%, showing its antioxidant ability.

2. ZO – 1 Protein Expression

At 0.04 mg/mL concentration, there is a 3.38 – fold relative expression of ZO – 1 protein.

3. Synergistic Effects with Retinoic Acid

It reduces irritation, enhances efficacy, and reduces water loss when used with retinoic acid.

Hair Loss Prevention

1. Clinical Study Design

A well – designed study was conducted to evaluate the efficacy ofNanoActiveMN on hair loss prevention.

2. Study Results

There was a significant improvement in hair abundance, density, quality, and thickness, with no adverse effects reported.

3. Mechanism of Action

It converts to NAD + in the scalp, enhancing cellular energy, improving barrier function, stimulating hair follicle cell renewal, and reducing oxidative stress.

Company Introduction

PuriPharmCo. Ltd.

1. Company Background

Specialized in bioactive ingredients, founded by industry experts and has global partnerships with research institutions.

2. Quality & Manufacturing

Strict quality control standards, state – of – the – art manufacturing facilities, and sustainable practices are in place.

3. R&D Capabilities

An expert technical team with PhD – level scientists and advanced laboratory facilities for cosmetic ingredient development.

Core Technologies

Nano Delivery：Advanced nanotechnology for enhanced bioavailability and targeted delivery of active ingredients.

Targeted Action：Allows for targeted action of ingredients at specific skin or hair sites.

Enhanced Penetration：Improves the penetration of ingredients into the skin for better efficacy.

Improved Stability： Ensures the stability of formulations during storage and use.

Formulation Stability

Stability information under different conditions

1. 24 – months Stability at Room Temperature

NanoActiveMN shows good stability in various formulations at room temperature for 24 months.

2. 3 – months Stability at 40℃

It has 3 – months stability at 40℃ in accelerated testing.

3. Minimal Degradation in Complex Formulations

There is minimal degradation in complex cosmetic matrices, ensuring long – term effectiveness.

Storage & Compatibility

Storage Conditions：

Store at 4 – 25℃ in a dry environment, protect from light, and keep the container tightly sealed.

Tested Formulations

It has been tested with various ingredients such as UV filters, emollients, humectants, natural oils, etc.

Ingredient Compatibility

Compatible with a wide range of cosmetic ingredients, including retinoids, antioxidants, emulsifiers, and thickeners.