PURIACTIVES® PAD

Posted on 06/23/202606/23/2026 by L, Y

PURIPHARM CO. LTD. & PURIACTIVES® PLATFORM

PuriPharm Co. Ltd. is a leading supplier of high-purity functional cosmetic actives, specializing in nano-encapsulation and advanced delivery systems for the global beauty industry.

The PuriActives® platform represents a portfolio of science-backed, formulation-friendly active ingredients designed for modern skin and scalp care formulations.

Each ingredient in the PuriActives® portfolio is selected and optimized for:

Demonstrated efficacy through scientific literature and in-house validation
Optimal formulation compatibility across a broad range of cosmetic product types
Regulatory compliance for North American, European, and Asian markets
Supply reliability and consistent batch-to-batch quality

PRODUCT SNAPSHOT

WHY POTASSIUM AZELOYL DIGLYCINATE?

Azelaic acid is a well-recognized cosmetic ingredient with multiple skin benefits. However, its practical use in cosmetic formulations has been limited by poor water solubility, low pH requirements, and skin tolerability concerns.

Potassium azeloyl diglycinate (PAD) was developed as a water-soluble derivative that retains the beneficial properties of azelaic acid while overcoming its formulation limitations.

FROM AZELAIC ACID TO A FORMULATION-FRIENDLY DERIVATIVE

Side-by-side comparison of key properties

TECHNICAL PROFILE & QUALITY SPECIFICATIONS

MARKET NEED

Oily, Blemish-Prone, Uneven-Tone & Sensitive Skin

Global consumers increasingly seek multifunctional, gentle solutions for complex skin concerns. PuriActives® PAD addresses all of these needs in a single molecule.

MECHANISM OVERVIEW: MULTI-PATHWAY SKIN BALANCE

PuriActives® PAD works through five complementary pathways for comprehensive skin, scalp, and hair benefits:

Brightening Mechanism: Tyrosinase / Melanin Pathway

Tyrosinase — The Rate-Limiting Enzyme

Tyrosinase catalyzes the conversion of tyrosine to melanin pigments in melanocytes. It is the key regulatory enzyme in melanin synthesis, making it a primary target for skin-brightening actives.

PAD Mechanism of Action

PuriActives® PAD has been reported to inhibit tyrosinase activity, helping to reduce melanin production and supporting a brighter, more even-looking skin tone.

Key Pathway Cascade

PAD → Tyrosinase Inhibition → Reduced Melanin Synthesis → Brighter Skin Appearance

Clinical Relevance

Tyrosinase inhibitors are widely used in cosmetic brightening products. PAD offers a water-soluble, well-tolerated alternative for formulators seeking brightening efficacy without the formulation challenges of azelaic acid.

Uneven Tone and Dark Spot Care

Dark spots and uneven skin tone result from localized melanin overproduction, often triggered by UV exposure, hormonal changes, or post-inflammatory responses. PuriActives® PAD helps address this through its tyrosinase-inhibition-related activity, supporting a more uniform-looking complexion over continued use.

Sebum Balance Mechanism

Blemish-Prone Skin Care Positioning

Excess sebum, inflammation, and blemish formation are interconnected concerns. PuriActives® PAD’s dual action — sebum balance support plus anti-inflammatory properties — makes it well-suited for blemish-prone skin care formulations.

Redness-Prone and Sensitive-Skin Comfort

Redness-prone skin is often associated with elevated inflammatory mediators, including IL-1α (interleukin-1 alpha), a key pro-inflammatory cytokine. PuriActives® PAD has been reported to help reduce IL-1α release, providing anti-inflammatory support that soothes the appearance of redness. Combined with glycine’s skin-conditioning properties and a neutral pH of 6.5–7.5, PAD offers excellent tolerance for sensitive skin.

Hydration and Elasticity Support

The glycine moiety in PuriActives® PAD contributes humectant and skin-conditioning properties. Glycine is a naturally occurring amino acid that helps support skin moisture retention, elasticity, and suppleness — complementing brightening and sebum-balancing benefits to create a well-rounded multifunctional active.

Scalp Care Opportunity

Scalp health is increasingly recognized as the foundation of healthy-looking hair. Oily scalp, discomfort, and imbalance are common concerns. PuriActives® PAD’s sebum-regulating and anti-inflammatory properties translate effectively to scalp care, offering brands a science-backed active for this emerging category.

Hair-Care Mechanism: 5α-Reductase / IL-1α / Scalp Balance

Hair Fiber Care Patent Story

Formulation Advantages

Recommended Use Level & Formulation Formats

Application Concepts

Claim Language & Regulatory-Friendly Wording

Competitive Value Proposition

Summary: One Molecule, Skin + Scalp + Hair Balance

PuriActives® PALMITOYL METHOXYTRYPTAMINE

Posted on 06/16/202606/16/2026 by L, Y

Available in Pure Crystalline Powder & NanoActive® Water-Soluble Liquid Grades

1. PRODUCT IDENTIFICATION

Trade Name: PuriActives® PALMITOYL METHOXYTRYPTAMINE (Pure Powder Grade) / NanoActive® PALMITOYL METHOXYTRYPTAMINE (Water-Soluble Liquid Grade)
INCI Name (US/EU):

Pure Powder Grade: Palmitoyl Methoxytryptamine

NanoActive® Grade: Water, Glycerin, Phospholipids, Palmitoyl Methoxytryptamine, Caprylic/Capric Glyceride

Chemical Name (Active): N-[2-(5-methoxy-1H-indol-3-yl)ethyl]hexadecanamide
CAS Number (Active): 224422-91-3
Molecular Formula (Active): C₂₇H₄₄N₂O₂
Molecular Weight (Active): 428.66 g/mol
Chemical Structure: CH₃-(CH₂)₁₄-CO-NH-CH₂-CH₂-C₈H₄(OCH₃)NH

2. PRODUCT DESCRIPTION

PuriActives® Palmitoyl Methoxytryptamine is a high-purity, bio-mimetic lipid-alkaloid conjugate engineered to deliver profound neuro-cosmetic soothing and cellular anti-inflammatory benefits. By coupling the potent neuro-active molecule 5-methoxytryptamine (a direct analog and precursor of melatonin) with palmitic acid, this compound exhibits exceptional skin-penetration kinetics and lipid-membrane affinity.

To address the inherent solubility limitations of the pure lipophilic crystalline powder in water-based cosmetic architectures, PuriPharm offers NanoActive® Palmitoyl Methoxytryptamine. Utilizing state-of-the-art advanced nano-delivery technology, this grade encapsulates the active within a biomimetic phospholipid bilayer membrane (average particle size < 100 nm). This advanced delivery system transforms a highly lipophilic compound into a thermodynamic-stable, optically transparent, and water-dispersible active, dramatically boosting skin bioavailability and offering effortless formulation flexibility.

3. CORE MECHANISMS OF ACTION

A. Neurogenic Soothing via TRP Channel Modulation

Sensitive skin is characterized by hyper-excited sensory nerve endings. Palmitoyl Methoxytryptamine acts as a gentle, soothing modulator of neurogenic pathways. It targets transient receptor potential (TRP) channels, specifically mitigating the over-activation of TRPV1 (capsaicin receptor), which in turn suppresses sensations of burning, stinging, tightness, and itching.

B. Anti-Inflammaging & PPAR-α Activation

Similar to endogenous endocannabinoid-like molecules (such as Palmitoylethanolamide / PEA), Palmitoyl Methoxytryptamine serves as an agonist for the nuclear receptor PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha). This activation triggers downstream anti-inflammatory cascades:

Inhibits the release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α.
Suppresses mast cell degranulation, mitigating sudden skin redness and histamine-induced itchiness.

C. Melatonin Receptor Agonism & Circadian Repair

Because 5-methoxytryptamine is a direct deacetylation analog of melatonin (N-acetyl-5-methoxytryptamine), Palmitoyl Methoxytryptamine acts as a highly potent biomimetic agent for cutaneous melatonin receptors (MT1 and MT2). This direct agonism:

Resets and synchronizes the skin’s biological clock genes (such as CLOCK and PER1).
Enhances the skin’s endogenous defense against oxidative stress induced by ultraviolet (UV) radiation and blue light.
Accelerates nocturnal DNA repair and cell regeneration, restoring a radiant and rested complexion overnight.

D. Enhanced Bioavailability via Lipophilic Vectoring & Nano-Carrier Delivery

Pure Powder: Conjugation with palmitic acid increases the partition coefficient (log P ≈ 7.15), allowing the active to integrate seamlessly into the intercellular lipid matrix of the stratum corneum.
NanoActive® Liquid: The phospholipid membrane of the nano-carriers fuses directly with the lipid bilayers of the stratum corneum. This bypasses the rate-limiting barrier of intercellular lipid transport, creating a “depot effect” in the viable epidermis and accelerating cellular uptake of the active molecule.

4. TECHNICAL SPECIFICATIONS

[Grade A] PuriActives® PALMITOYL METHOXYTRYPTAMINE (Pure Powder)

[Grade B] NanoActive® PALMITOYL METHOXYTRYPTAMINE (Water-Soluble Liquid)

Microbiological Specifications (Both Grades)

Total Aerobic Plate Count: ≤ 100 CFU/g
Yeasts and Molds: ≤ 10 CFU/g
Pathogens (E. coli, S. aureus, P. aeruginosa): Negative/g

5. COSMETIC BENEFITS & CLINICAL CLAIMS

Instant Neuro-Soothing: Rapidly reduces sensory discomfort, itching, and neuro-sensitivity.
Anti-Redness & Erythema Control: Dampens micro-vascular reactivity and controls flushing in rosacea-prone skin.
Skin Barrier Recovery: Accelerates epidermal barrier repair and decreases trans-epidermal water loss (TEWL).
Intense Inflammaging Defense: Protects structural proteins (collagen and elastin) from enzymatic degradation caused by chronic low-grade inflammation.
Chronobiological Renewal: Aids in resetting skin repair rhythms, restoring a radiant and rested complexion overnight.

6. FORMULATION & PROCESSING GUIDELINES (PURE POWDER)

A. Recommended Usage Levels

Daily Soothing & Maintenance Creams: 0.05% – 0.2%
Intensive SOS / Post-Procedure Care: 0.2% – 0.5%

B. Solubility & Incorporation

Oil Phase: Soluble in hot cosmetic esters and lipids (e.g., Caprylic/Capric Triglyceride, Squalane, C12-15 Alkyl Benzoate) at 75°C – 80°C.
Water Phase: Insoluble in water.

C. Processing Temperature

● Stable at temperatures up to 85°C. It is recommended to dissolve the active in the oil phase before emulsification.

7. FORMULATION & PROCESSING GUIDELINES (NANOACTIVE® LIQUID)

A. Recommended Usage Levels

Daily Soothing Serums & Toners: 1.0% – 4.0% (Equivalent to 0.05% – 0.2% pure active)
High-Concentration Clinical Soothing Ampoules: 4.0% – 10.0% (Equivalent to 0.2% – 0.5% pure active)

B. Solubility & Incorporation

Water Phase: 100% dispersible in water. It yields an elegant, optically transparent solution, ideal for clear gel, serum, toner, and essence formulations.
Incorporation: Highly recommended to add to the water phase or post-emulsification phase during the cooling stage at temperatures below 40°C.

C. Processing Guidelines & Shear Sensitivity

● Avoid exposing NanoActive® grade to high-shear homogenization equipment (e.g., rotor-stator homogenizers) for prolonged periods, as extreme shear can disrupt the lipid vesicle bilayers. Use paddle stirring or gentle marine propellers to disperse.

D. pH Stability (NanoActive®)

● Optimum stability is observed within a pH range of 4.5 – 6.5.

8. STORAGE, SHELF LIFE & REGULATORY

● Storage Conditions: Store in the original, tightly sealed container.

Pure Powder: Keep in a cool, dry, and well-ventilated area, preferably refrigerated at 2°C – 8°C for long-term storage.
NanoActive® Liquid: Do not freeze. Store at 4°C – 25°C, protected from direct sunlight and heat.

● Shelf Life: 24 months from the date of manufacture when stored under prescribed conditions.

● Regulatory Compliance: Approved for use in cosmetics worldwide (including EU, USA, and China IECIC listing). Vegan-compliant, cruelty-free, and non-GMO.

Disclaimer: The information contained in this document is provided in good faith and is based on our current technical knowledge. Formulation results may vary depending on other raw materials and processing equipment used. It is the formulator’s responsibility to conduct final product safety and efficacy tests.

NANOACTIVE ENOXOLONE PuriActives Core Molecule x NanoActive Delivery

Posted on 06/15/202606/15/2026 by L, Y

PuriPharm: Dual Pillars of Innovation

Two Core Innovation Pillars

PuriActives: Enoxolone from Licorice Root

NanoActive NanoCarrier: Delivery Architecture

Application Challenges: Enoxolone Limitations

NanoActive System Solution

NanoActive Enoxolone = PuriActives Molecule + NanoActive Technology

Through nano-encapsulation, insoluble crystalline powder becomes a clear, transparent, stable bioactive liquid. We deliver precision-calculated efficacy.

NanoActive Parameters: Size Advantage

Product Technical Specifications

NanoActive Drives Deep Penetration

Multi-dimensional Efficacy

Anti-inflammatory Power: TSLP Inhibition

Clinical Evidence: Atopic Dermatitis Relief

NanoActive Antioxidant Defense Matrix

11β-HSD1 Inhibition: Correcting Steroid Skin

Antimicrobial Activity

Skin Barrier Repair & Soothing

Formulation Application Guide

PuriActives® PALMITOYL TRYPTAMINE

Posted on 06/14/202606/14/2026 by L, Y

Available in Pure Crystalline Powder & NanoActive® Water-Soluble Liquid Grades

1. PRODUCT IDENTIFICATION

Trade Name: PuriActives® PALMITOYL TRYPTAMINE (Pure Powder Grade) / NanoActive® PALMITOYL TRYPTAMINE (Water-Soluble Liquid Grade)

INCI Name (US/EU):

Pure Powder Grade: Palmitoyl Tryptamine
NanoActive® Grade: Water, Glycerin, Phospholipids, Palmitoyl Tryptamine, Caprylic/Capric Triglyceride
Chemical Name (Active): N-[2-(1H-indol-3-yl)ethyl]hexadecanamide
CAS Number (Active): 21469-15-8
Molecular Formula (Active): C₂₆H₄₂N₂O
Molecular Weight (Active): 398.63 g/mol
Chemical Structure: CH₃-(CH₂)₁₄-CO-NH-CH₂-CH₂-C₈H₅NH

2. PRODUCT DESCRIPTION

PuriActives® Palmitoyl Tryptamine is a high-purity, bio-mimetic lipid-alkaloid conjugate engineered to deliver profound neuro-cosmetic soothing and cellular anti-inflammatory benefits. By coupling the potent neuro-active molecule tryptamine with palmitic acid, this compound exhibits exceptional skin-penetration kinetics and lipid-membrane affinity.

To address the inherent solubility limitations of the pure lipophilic crystalline powder in water-based cosmetic architectures, PuriPharm offers NanoActive® Palmitoyl Tryptamine. Utilizing state-of-the-art advanced nano-delivery technology, this grade encapsulates the active within a biomimetic phospholipid bilayer membrane (average particle size < 100 nm). This advanced delivery system transforms a highly lipophilic compound into a thermodynamic-stable, optically transparent, and water-dispersible active, dramatically boosting skin bioavailability and offering effortless formulation flexibility.

3. CORE MECHANISMS OF ACTION

A. Neurogenic Soothing via TRP Channel Modulation

Sensitive skin is characterized by hyper-excited sensory nerve endings. Palmitoyl Tryptamine acts as a gentle, soothing modulator of neurogenic pathways. It targets transient receptor potential (TRP) channels, specifically mitigating the over-activation of TRPV1 (capsaicin receptor), which in turn suppresses sensations of burning, stinging, tightness, and itching.

B. Anti-Inflammaging & PPAR-α Activation

Similar to endogenous endocannabinoid-like molecules (such as Palmitoylethanolamide / PEA), Palmitoyl Tryptamine serves as an agonist for the nuclear receptor PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha). This activation triggers downstream anti-inflammatory cascades:

Inhibits the release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α.
Suppresses mast cell degranulation, mitigating sudden skin redness and histamine-induced itchiness.

C. Melatonin Pathway Synergy & Circadian Repair

Because tryptamine is an biochemical precursor in the melatonin and serotonin synthesis pathways, topical application of Palmitoyl Tryptamine supports the skin’s nocturnal repair mechanisms. It enhances the skin’s endogenous defense against oxidative stress induced by ultraviolet (UV) radiation and blue light, helping to maintain cellular homeostasis during sleep.

D. Enhanced Bioavailability via Lipophilic Vectoring & Nano-Carrier Delivery

Pure Powder: Conjugation with palmitic acid increases the partition coefficient (log P ≈ 6.83), allowing the active to integrate seamlessly into the intercellular lipid matrix of the stratum corneum.
NanoActive® Liquid: The phospholipid membrane of the nano-carriers fuses directly with the lipid bilayers of the stratum corneum. This bypasses the rate-limiting barrier of intercellular lipid transport, creating a “depot effect” in the viable epidermis and accelerating cellular uptake of the active molecule.

4. TECHNICAL SPECIFICATIONS

[Grade A] PuriActives® PALMITOYL TRYPTAMINE (Pure Powder)

[Grade B] NanoActive® PALMITOYL TRYPTAMINE (Water-Soluble Liquid)

Microbiological Specifications (Both Grades)

Total Aerobic Plate Count: ≤ 100 CFU/g
Yeasts and Molds: ≤ 10 CFU/g
Pathogens (E. coli, S. aureus, P. aeruginosa): Negative/g

5. COSMETIC BENEFITS & CLINICAL CLAIMS

Instant Neuro-Soothing: Rapidly reduces sensory discomfort, itching, and neuro-sensitivity.
Anti-Redness & Erythema Control: Dampens micro-vascular reactivity and controls flushing in rosacea-prone skin.
Skin Barrier Recovery: Accelerates epidermal barrier repair and decreases trans-epidermal water loss (TEWL).
Intense Inflammaging Defense: Protects structural proteins (collagen and elastin) from enzymatic degradation caused by chronic low-grade inflammation.
Chronobiological Renewal: Aids in resetting skin repair rhythms, restoring a radiant and rested complexion overnight.

6. FORMULATION & PROCESSING GUIDELINES (PURE POWDER)

A. Recommended Usage Levels

Daily Soothing & Maintenance Creams: 0.05% – 0.2%
Intensive SOS / Post-Procedure Care: 0.2% – 0.5%

B. Solubility & Incorporation

Oil Phase: Soluble in hot cosmetic esters and lipids (e.g., Caprylic/Capric Triglyceride, Squalane, C12-15 Alkyl Benzoate) at 75°C – 80°C.
Water Phase: Insoluble in water.

C. Processing Temperature

●Stable at temperatures up to 85°C. It is recommended to dissolve the active in the oil phase before emulsification.

7. FORMULATION & PROCESSING GUIDELINES (NANOACTIVE® LIQUID)

A. Recommended Usage Levels

Daily Soothing Serums & Toners: 1.0% – 4.0% (Equivalent to 0.05% – 0.2% pure active)
High-Concentration Clinical Soothing Ampoules: 4.0% – 10.0% (Equivalent to 0.2% – 0.5% pure active)

B. Solubility & Incorporation

Water Phase: 100% dispersible in water. It yields an elegant, optically transparent solution, ideal for clear gel, serum, toner, and essence formulations.
Incorporation: Highly recommended to add to the water phase or post-emulsification phase during the cooling stage at temperatures below 40°C.

C. Processing Guidelines & Shear Sensitivity

Avoid exposing NanoActive® grade to high-shear homogenization equipment (e.g., rotor-stator homogenizers) for prolonged periods, as extreme shear can disrupt the lipid vesicle bilayers. Use paddle stirring or gentle marine propellers to disperse.

D. pH Stability (NanoActive®)

Optimum stability is observed within a pH range of 4.5 – 6.5.

8. STORAGE, SHELF LIFE & REGULATORY

Storage Conditions: Store in the original, tightly sealed container.
Pure Powder: Keep in a cool, dry, and well-ventilated area, preferably refrigerated at 2°C – 8°C for long-term storage.
NanoActive® Liquid: Do not freeze. Store at 4°C – 25°C, protected from direct sunlight and heat.
Shelf Life: 24 months from the date of manufacture when stored under prescribed conditions.
Regulatory Compliance: Approved for use in cosmetics worldwide (including EU, USA, and China IECIC listing). Vegan-compliant, cruelty-free, and non-GMO.

PuriActives® SupraSalix Supramolecular Salicylic Acid

Posted on 06/13/202606/13/2026 by L, Y

Technical Dossier | PuriPharm Co. Ltd. —— A Breakthrough 3-in-1 Targeted Solution: Sebum Control • Barrier Repair • Microbiome Balance

1. Product Overview

Traditional Salicylic Acid (SA) is highly efficacious in anti-acne and sebum control treatments. However, its free-acid form is notoriously associated with adverse effects, including severe irritation, flaking, and disruption of the skin barrier. To address this persistent industry challenge, PuriPharm Co. Ltd. has engineered PuriActives® SupraSalix (Supramolecular Salicylic Acid), specifically designed for modern sensitive skin and compromised complexions.

Powered by cutting-edge supramolecular self-assembly technology, PuriActives® SupraSalix utilizes a core of Salicylic Acid and Zinc Amino Acid. It innovatively integrates the biomimetic repair network of Xyloglucan and the prebiotic engine of α-Glucan Oligosaccharide.

This active ingredient shatters the traditional paradigm that “anti-acne equals barrier damage.” By achieving a 4D synergistic effect—sustained-release desensitization, comedolytic sebum control, biomimetic repair, and microbiome balance—it stands as a next-generation, ultra-mild anti-acne active formulated for sensitive skin, acne vulgaris, and seborrheic dermatitis.

2. Core Components & Mechanism of Action

The exceptional efficacy of PuriActives® SupraSalix originates from its meticulously designed matrix of four core components:

2.1 The Core Anti-Acne Engine: Salicylic Acid & Zinc Amino Acid

A supramolecular network cleverly conjugates Salicylic Acid with Zinc Amino Acid (primarily Zinc Glycinate) to achieve “reduced toxicity, enhanced efficacy” alongside kinetic sustained release.

Salicylic Acid: A lipophilic BHA that penetrates deep into hair follicles to dissolve keratin plugs and sebum, exerting potent comedolytic action. Simultaneously, it inhibits COX enzyme activity to block the production of pro-inflammatory mediators like prostaglandins.
Zinc Ion: An essential trace element. It inhibits 5α-reductase activity, significantly reducing sebum hypersecretion at the source. It also disrupts pathogenic biofilms for broad-spectrum antimicrobial action while accelerating wound healing and tissue remodeling.
Amino Acid (e.g., Glycine): The smallest amino acid. It not only acts as a carrier to enhance Zinc’s skin penetration but is also a critical component of the Natural Moisturizing Factor (NMF) and collagen, effectively soothing localized dryness caused by acid peeling.

2.2 The Invisible Biomimetic Barrier: Xyloglucan

A natural polysaccharide extracted from Tamarind seeds, widely recognized in pharmaceutical applications for treating eczema, dermatitis, and psoriasis.

“Second Skin” Effect: Exhibits outstanding film-forming properties, creating a breathable, invisible biomimetic shield on the skin surface to defend against external aggressors (e.g., PM2.5, allergens).
Deep Hydration & Repair: Significantly reduces Transepidermal Water Loss (TEWL), providing a moist healing microenvironment for a compromised stratum corneum. It synergizes with amino acids to accelerate barrier repair and diminish erythema (redness) and acne marks.

2.3 The Microbiome Modulator: α-Glucan Oligosaccharide

A highly active, plant-derived prebiotic.

Targeted Feeding: Selectively promotes the proliferation of beneficial skin flora (e.g., Staphylococcus epidermidis) while remaining indigestible to pathogens (e.g., Cutibacterium acnes, Malassezia).
Competitive Inhibition: By robustly cultivating beneficial bacteria to occupy the ecological niche, it competitively inhibits the microorganisms responsible for acne and seborrheic dermatitis, cutting off the root cause of recurrent breakouts from an ecological standpoint.

3. 4D Synergy Matrix

PuriActives® SupraSalix is not a simple physical blend. Through PuriPharm’s supramolecular technology, it establishes a 1+1+1>3 synergistic network:

1D Clear & Control: SA pore unclogging + Zinc’s active sebaceous inhibition. A dual-action approach to drastically improve oily skin and congested pores.
2D Targeted Anti-inflammatory: Zinc (inhibiting the upstream NF-kB pathway) combined with SA (inhibiting the downstream COX pathway). Delivers rapid erythema reduction and soothes inflamed papules.
3D Biomimetic Repair: Xyloglucan’s physical film-forming + Amino acid’s biochemical hydration. Perfectly neutralizes the harsh peeling effects of acids, enabling simultaneous “Clear & Repair.”
4D Microbiome Balance: α-Glucan Oligosaccharide reconstructs the microbial barrier, complementing the antimicrobial properties of Zn and SA. It systematically improves acne-prone and reactive skin profiles, preventing future relapses.

4. Core Advantages vs. Benchmark

5. Applications & Formulation Guidelines

PuriActives® SupraSalix demonstrates exceptional compatibility and solubility, making it highly versatile for various cosmetic formats including toners, serums, emulsions, gels, and wash-off products.

Primary Application Scenarios:

Professional Acne/Comedone Care: Anti-acne serums, spot treatment gels, chemical peel solutions (highly recommended for sensitive skin peeling).
Sebum & Pore Management: Pore-refining toners, mattifying/balancing emulsions, deep-cleansing mud masks.
Seborrheic Dermatitis & Scalp Care: Anti-dandruff shampoos, scalp oil-control serums, scalp microbiome treatments.
SOS Redness & Repair Care: Post-extraction soothing treatments, anti-inflammatory products for barrier-compromised phases.

Formulation Guidelines:

Appearance: (Please refer to the actual product COA)
Solubility: Excellent water solubility; easily incorporated into the aqueous phase.
Recommended Dosage: 1.0% – 5.0% (Depending on specific product claims and efficacy substantiation).
Optimal pH Range: 4.0 – 6.5 (A mildly acidic environment favors the stability of the supramolecular network and SA activity. Strongly alkaline environments should be avoided).
Compatibility: Pairs excellently with active ingredients such as Niacinamide, Hyaluronic Acid, and Ceramides. Note: Avoid prolonged co-existence with high concentrations of strong metal chelating agents (e.g., EDTA) in the same system to prevent competitive disruption of the Zinc complex structure.

Copyright Statement: PuriActives® is a registered trademark of PuriPharm Co. Ltd. The information provided in this document is based on current scientific research and in vitro / in vivo testing, intended solely as a reference for formulators and R&D professionals.

PuriActives® Sodium Algin Sulfate The Marine-Derived GAGs Biomimetic for Ultimate Cellular Regeneration

Posted on 06/09/202606/09/2026 by L, Y

Company: PuriPharm Co. Ltd.

Product Category: Active Ingredient / Anti-Aging & Skin Barrier Repair

Format: Technical & Marketing Brochure

1. Executive Summary

PuriActives® Sodium Algin Sulfate is an advanced, highly purified sulfated polysaccharide derived from premium marine brown algae. Engineered through precise biomimetic biotechnology, it acts as a structural and functional analogue to endogenous Glycosaminoglycans (GAGs), specifically Heparan Sulfate.

By mimicking the extracellular matrix’s (ECM) natural biological environment, Sodium Algin Sulfate plays a crucial role in stabilizing growth factors, reducing chronic inflammation (“inflammaging”), and accelerating deep skin tissue repair. It is the ultimate marine-biotech solution for premium anti-aging, soothing, and post-procedure recovery formulations.

2. The Scientific Rationale: A Master of the Extracellular Matrix (ECM)

As skin ages, the natural pool of Heparan Sulfate in the ECM depletes, leading to structural collapse, impaired cellular communication, and accelerated wrinkling.

PuriActives® Sodium Algin Sulfate features a precisely controlled Degree of Sulfation (DS) that closely mimics human GAGs.

Growth Factor Stabilization: Its negatively charged sulfated topology allows it to bind specifically to endogenous growth factors (e.g., FGF, EGF, TGF-β), protecting them from proteolytic degradation and amplifying their signaling pathways for collagen synthesis.
MMP Inhibition: It competitively binds to and inhibits Matrix Metalloproteinases (MMPs), particularly Hyaluronidase and Elastase, preserving the skin’s natural hyaluronic acid and elastin reservoirs.

3. Core Clinical Efficacies

I. Profound Anti-Aging & Wrinkle Reduction

By acting as a biological reservoir for growth factors, Sodium Algin Sulfate stimulates fibroblast proliferation and upregulates the synthesis of Collagen I and III. It restores the dermal-epidermal junction (DEJ) architecture, resulting in visibly firmer skin and a reduction in fine lines.

II. Rapid Barrier Repair & Soothing

Exhibiting exceptional anti-inflammatory properties, it actively downregulates pro-inflammatory cytokines (such as IL-1α and TNF-α). It accelerates epidermal re-epithelialization, making it highly effective for sensitive skin, rosacea, and post-aesthetic procedure care (e.g., post-laser, post-peel).

III. Deep, Sustained Hydration

Unlike standard humectants that merely hold water on the surface, its high molecular weight and dense charge network create a breathable, 3D bio-polymeric film. This shields against trans-epidermal water loss (TEWL) while actively modulating cellular hydration channels from within.

4. Technical Specifications & Formulation Guidelines

INCI Name: Sodium Algin Sulfate (and) Water (Aqua)
Appearance: Clear to slightly yellowish, viscous liquid.
Odor: Characteristic (mild marine origin).
Solubility: 100% soluble in water. Insoluble in oils and high concentrations of ethanol.
pH Value (at 20°C): 5.0 – 7.5
Recommended Usage Level: 1.0% – 5.0%

Formulation Advantages (The PuriPharm Edge):

High Compatibility: Compatible with a wide range of cosmetic chassis, including clear serums, O/W emulsions, and hydrogels.
Stability: Highly stable against thermal stress (up to 80°C) and light. Can be added to the aqueous phase before homogenization or post-added during the cooling phase below 40°C.
Synergistic Potential: Pairs perfectly with peptides, ceramides, and PuriPharm’s NanoActive® encapsulates (like NanoActive® Phloretin) for comprehensive anti-aging and barrier-repair protocols.

5. Application Horizons

Intensive Anti-Aging Serums: To restructure the dermal matrix and enhance firmness.
Dermatological Soothing Creams: For hypersensitive, reactive, or compromised skin.
Post-Procedure Care: Accelerating recovery after laser treatments, micro-needling, or chemical peels.
Scalp Care Therapies: Reducing scalp inflammation and maintaining follicular ECM health.

PuriPharm Co. Ltd.

Active Science. Advanced Delivery. Real Impact.

For technical dossiers, material safety data sheets (MSDS), or formulation assistance, please contact our R&D support team.

Email: Service@puripharm.com | Web: www.PuriActives.com

NanoActive™ Phloretin Redefining Efficacy with Advanced Nano-Delivery Technology

Posted on 06/05/202606/05/2026 by L, Y

1. Product Overview

Phloretin, an extraordinary dihydrochalcone polyphenol derived from the root bark of Malus domestica (apple tree), is celebrated for its multi-functional benefits: remarkable tyrosinase inhibition, potent radical scavenging, and cellular DNA protection. However, traditional crystalline Phloretin is notoriously difficult to formulate due to poor water solubility, high oxidation susceptibility, and inability to penetrate the stratum corneum barrier effectively.

PuriPharm introduces NanoActive™ Phloretin—powered by our proprietary Advanced Nano-Delivery System Technology. By encapsulating Phloretin within a sub-50nm nanostructured lipid matrix, we have unlocked its full potential, transforming nature’s most potent antioxidant into a stable, highly bioavailable formulation solution.

2. Key Benefits at a Glance

Breakthrough Bioavailability: Amphiphilic architecture enables seamless delivery across skin barriers.

Enhanced Stability: Protects the active payload from premature oxidation and degradation.

Formulation Freedom: Cold-processable, 100% water-dispersible, and prevents recrystallization or color shift.

Unmatched Potency: Delivers 94% radical scavenging efficiency and powerful tyrosinase inhibition (IC50 = 37.5 μmol/L).

3. The Science Behind the Innovation

Advanced Whitening & Melanin Regulation

Acts at the cellular level to inhibit tyrosinase activity. Fades post-inflammatory hyperpigmentation (PIH) and dramatically improves skin luminosity (L* value) without irritation.

Broad-Spectrum Antioxidant Matrix

Neutralizes reactive oxygen species (ROS) far more effectively than crystalline alternatives. The nano-delivery system ensures max dispersion in aqueous environments, achieving 94% scavenging efficiency—outperforming standard Vitamin C.

Acne Mitigation & Sebum Control

Targets sebaceous glands to reduce excess lipogenesis while inhibiting pro-inflammatory markers (PGE2, COX-2). Promotes a long-lasting matte finish and accelerates blemish recovery.

Deep Cellular DNA Defense

Shields cellular DNA from UV-induced Thymine Dimer formation and prevents the degradation of collagen by blocking MMP-9 expression, addressing the root causes of photoaging.