Category Archives: Biotechnology

NanoActive® RAL (Liposomal Retinal) Advanced Vitamin A Technology for High-Performance Skin Care

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Company & Brand Background

PuriPharm Co. Ltd. is a science-driven company specializing in the research, development, and commercialization of high-performance functional bioactive ingredients. With a strong foundation in pharmaceutical science, biotechnology, and advanced formulation technologies, PuriPharm is dedicated to delivering safe, effective, and innovative active ingredient solutions for the global cosmetics, personal care, and biomedical industries.

PuriPharm operates two core product platforms:

• PuriActives® – a portfolio of high-quality functional bioactives derived from natural, bio-based, and scientifically validated sources.

• NanoActive® – an advanced nano-delivery ingredient platform designed to enhance the stability, bioavailability, and efficacy of sensitive active compounds through cutting-edge encapsulation technologies.

NanoActive® RAL (Liposomal Retinal) is a flagship product of the NanoActive® series, representing PuriPharm’s expertise in vitamin A chemistry, lipid delivery systems, and skin bioavailability optimization.

Retinal, also known as retinaldehyde (RAL), is a highly active form of vitamin A and a direct biochemical precursor of retinoic acid, the biologically active molecule responsible for many of vitamin A’s well-known skin benefits.

Unlike retinol, which requires a two-step enzymatic conversion process in the skin, retinal converts to retinoic acid in only one step. As a result, retinal delivers faster and more efficient biological activity at significantly lower concentrations.

Scientific and clinical studies have demonstrated that:

• Retinal converts to retinoic acid approximately 11 times faster than retinol

• Retinal offers efficacy comparable to retinoic acid but with significantly improved skin tolerance

• Retinal provides powerful anti-aging, skin-renewing, and collagen-stimulating effects with reduced irritation

For these reasons, retinal is widely recognized as one of the most advanced and effective vitamin A forms available for modern skin care formulations.

Why Choose Retinal Instead of Retinol?

Although retinol has long been used in cosmetic formulations, it presents several inherent limitations, including instability, oxidation, discoloration, and slow biological conversion.

Retinal offers distinct advantages:

• Faster efficacy – 11-fold faster conversion to retinoic acid compared with retinol

• Higher biological efficiency – closer to retinoic acid in the vitamin A metabolic pathway

• Improved skin tolerance – lower irritation potential compared with retinoic acid

• Broader functionality – supports anti-aging, acne control, skin tone improvement, and barrier repair

However, retinal itself is a chemically sensitive molecule that is prone to oxidation, light degradation, and discoloration. These challenges have historically limited its widespread use in cosmetic formulations.

NanoActive® RAL: Liposomal Retinal Technology

NanoActive® RAL overcomes the traditional limitations of retinal through an advanced liposomal nano-delivery system, enabling formulators to fully unlock the benefits of retinal in a stable, effective, and user-friendly form.

NanoActive® RAL is a lipid-encapsulated retinal, engineered using phospholipid bilayer technology that mimics the structure of biological cell membranes. This delivery system provides comprehensive protection and controlled release of retinal in the skin.

Key Features of NanoActive® RAL

• High stability – protected from oxidation, light exposure, and thermal degradation

• No discoloration – maintains formulation clarity and color stability over time

• Enhanced skin absorption – liposomal structure improves penetration and bioavailability

• Controlled release – gradual delivery minimizes irritation while maximizing efficacy

• Superior compatibility – easy to formulate into a wide range of cosmetic systems

Through nano-encapsulation, NanoActive® RAL ensures that retinal remains active, effective, and safe throughout the product’s shelf life and during skin application.

11 Times Faster Conversion to Retinoic Acid

One of the most important advantages of NanoActive® RAL is the intrinsic metabolic efficiency of retinal.

In the skin:

• Retinol → Retinal → Retinoic Acid (two-step conversion)

• Retinal → Retinoic Acid (one-step conversion)

This simplified pathway allows retinal to deliver results approximately 11 times faster than retinol, leading to quicker improvements in skin texture, tone, and visible signs of aging.

Because NanoActive® RAL enhances retinal delivery and stability, this rapid conversion can occur more efficiently and consistently within the skin.

Skin Benefits of NanoActive® RAL

NanoActive® RAL delivers a comprehensive range of clinically supported skin benefits:

Anti-Aging & Wrinkle Reduction

• Stimulates collagen and elastin synthesis

• Improves skin firmness, elasticity, and density

• Reduces the appearance of fine lines and wrinkles

Skin Renewal & Texture Improvement

• Accelerates epidermal cell turnover

• Smooths rough skin texture

• Promotes a more even and refined complexion

Brightening & Tone Correction

• Inhibits tyrosinase activity and melanin formation

• Enhances skin radiance and uniformity

• Helps fade hyperpigmentation and discoloration

Acne & Blemish Control

• Exhibits direct antibacterial activity against acne-causing bacteria

• Regulates sebum production

• Supports pore refinement and blemish recovery

Barrier Support & Repair

• Improves skin barrier integrity

• Enhances resilience against environmental stressors

• Supports long-term skin health and comfort

Superior Stability and Color Performance

Traditional retinal and retinol formulations often suffer from:

• Rapid degradation

• Yellowing or browning over time

• Loss of activity during storage

NanoActive® RAL is specifically designed to address these issues. The liposomal encapsulation effectively isolates retinal from environmental stress factors, resulting in:

• Excellent formulation stability

• Minimal color change over time

• Consistent performance throughout shelf life

This makes NanoActive® RAL ideal for premium skin care products where visual appearance, product consistency, and long-term efficacy are critical.

Easy Absorption & Skin Compatibility

The phospholipid-based nano-carriers used in NanoActive® RAL closely resemble the lipid structure of human skin. This biomimetic design allows for:

• Improved skin affinity

• Efficient penetration through the stratum corneum

• Targeted delivery to deeper skin layers

As a result, NanoActive® RAL is easily absorbed, non-greasy, and well tolerated, even in long-term use formulations.

NanoActive® RAL is suitable for a wide range of cosmetic and personal care applications, including:

• Anti-aging serums and creams

• Brightening and skin renewal products

• Acne treatment formulations

• Eye care products

• Barrier repair and post-treatment care

Its excellent compatibility allows formulators to incorporate NanoActive® RAL into emulsions, gels, lotions, and advanced delivery systems with ease.

A New Generation of Vitamin A Actives

By combining the proven biological power of retinal with state-of-the-art nano-delivery technology, NanoActive® RAL represents a new generation of vitamin A active ingredients.

It offers:

• Faster results than retinol

• Better tolerance than retinoic acid

• Greater stability than conventional retinal

• Enhanced user experience and formulation reliability

Conclusion

NanoActive® RAL (Liposomal Retinal) embodies PuriPharm Co. Ltd.’s commitment to scientific excellence, innovation, and performance. As a key product within the NanoActive® platform and a natural extension of the PuriActives® philosophy, NanoActive® RAL provides formulators and brands with a powerful, stable, and advanced vitamin A solution for next-generation skin care.

By delivering stable, non-discoloring, easily absorbed liposomal retinal with an 11-fold faster conversion to retinoic acid compared with retinol, NanoActive® RAL sets a new benchmark for efficacy, safety, and formulation sophistication in modern cosmetic science.

PuriActives® PuriVitin™

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1. PRODUCT IDENTITY
Trade Name: PuriActives® PuriVitin™
INCI Name (EU/US): Saccharide Isomerate, Aqua, Citric Acid, Sodium Citrate
CAS No.: 100843-69-4, 7732-18-5, 77-92-9, 68-04-2
Origin: 100% Plant-derived
General Description
PuriVitin™ is a highly effective, 100% plant-derived carbohydrate complex designed to provide deep, long-lasting hydration. Its unique composition is chemically similar to the carbohydrate fraction of the Natural Moisturizing Factor (NMF) found in human skin.
Unlike conventional humectants that can be easily washed off, PuriVitin™ binds physically to the skin’s keratin, creating a moisture reservoir that lasts for up to 72 hours. It is an essential active for formulations targeting instant hydration, barrier repair, and scalp comfort.

2. KEY BENEFITS & CLAIMS
“Magnet-Like” Skin Affinity
●Unique Binding Mechanism: PuriVitin™ binds to the epsilon-amino group of lysine in keratin. This unique binding mechanism ensures the active is not washed off by water, making it ideal for both leave-on and rinse-off products (e.g., shower gels, face cleansers).
●Long-Lasting Hydration: Provides sustained hydration for up to 72 hours, breaking the dry-skin cycle.
Skin Barrier Support
●Strengthens Barrier Function: Improves the skin’s defense against external aggressors (pollution, cold weather, dry air).
●Soothing Effect: Visible reduction in dryness, flakiness, and tightness associated with dehydrated skin.
●Scalp Care: effectively hydrates the scalp, reducing itchiness and improving the overall health of the scalp microbiome environment.
Sensory Profile
●Leaves skin feeling soft, plump, and smooth without stickiness.

3. COMPOSITION DATA

4. TECHNICAL SPECIFICATIONS
Physical & Chemical Properties

Microbiological Standards

5. MECHANISM OF ACTION
PuriVitin™ functions differently from traditional polyols (like glycerin) or macromolecules (like hyaluronic acid).
1.Isomerization: The glucose and fructose from plant kernels are isomerized to create a unique carbohydrate complex.
2.Bio-Mimicry: This complex mimics the composition of carbohydrates found naturally in the Stratum Corneum.
3.Keratin Binding: Upon application, PuriVitin™ forms a permanent bond with the keratinocytes. This bond is so strong that the moisture-locking effect persists until the dead skin cells naturally exfoliate (desquamation), ensuring hydration that outlasts washing.

6. APPLICATIONS & DOSAGE
Recommended Use Level: 1.0 – 5.0%
PuriVitin™ is suitable for a wide range of cosmetic applications:
Skin Care
●Daily Moisturizers: Day and night creams for instant and long-term hydration.
●Serums & Essences: Intensive hydration boosters.
●Anti-Aging: Plumps skin to reduce the appearance of fine lines caused by dehydration.
Rinse-Off Products
●Cleansers & Body Wash: Provides hydration that stays on the skin even after rinsing.
●Hand Soaps: Protects hands from dryness caused by frequent washing.
Hair & Scalp Care
●Shampoos & Conditioners: Hydrates the scalp to prevent flakes and itchiness.
●Hair Masks: Improves moisture retention in the hair shaft.
Body Care
●Body Lotions: For long-lasting comfort on dry areas (elbows, knees, heels).

7.FORMULATION GUIDELINES
●Solubility: Freely soluble in water. Insoluble in oils.
●Incorporation: Can be added to the water phase or at the end of the formulation process (cooling phase).
●Processing Temperature: Stable at temperatures up to 80°C. Can be processed hot or cold.
●pH Stability: Stable across a wide pH range (3.0 – 7.0 recommended for final formulation efficacy).
●Compatibility: Compatible with most cosmetic ingredients, including high concentrations of ethanol and electrolytes.

8. REGULATORY & STORAGE
Storage Conditions
●Store in the original, unopened container.
●Protect from direct sunlight and heat.
●Store at room temperature (15°C – 25°C).
Shelf Life
●36 months from the date of manufacture when stored under recommended conditions.
Packaging
●Standard industrial plastic containers (Drum/Jerry can).
Safety & Regulatory Status
●Vegan: Suitable for vegan formulations.
●Non-GMO: Produced from non-GMO plant sources.
●Preservative Status: Preservative-free (Self-preserving due to high solid content and osmotic pressure).

Disclaimer:
The information provided in this data sheet is based on our current knowledge and experience. It does not relieve the processor from carrying out their own tests and trials. A legally binding assurance of certain properties or suitability for a specific purpose cannot be derived from this data.
Manufacturer:
PuriPharm Co., Ltd.
PuriActives® is a registered trademark of PuriPharm Co., Ltd.

PuriBifido

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INCI Name :Bifida Ferment Lysate

Bifida Ferment Extract, Phenoxyethanol, Potassium Sorbate, Xanthan Gum

CAS No. None for now; 122-99-6; 24634-61-5; 11138-66-2

It is fermented by the compound bifidobacteria (known as bifidus yeast in the industry). It is a probiotic product that thoroughly improves the skin condition and can be classified as a skin micro-ecological active matter. The core ingredient of the Estee Lauder Advanced Night Repair is the bifidus yeast. The anti-ageing active ingredients extracted from the lysate of bifidobacteria through biotechnology can effectively protect skin, reduce the damage caused by ultraviolet rays to the skin, activate the immuno-suppressive process, stimulate endogenous skin protection, and promote cell repair. It can reduce skin spots, brighten the skin, reduce the number and degree of wrinkles, and smooth the skin. Bifidus yeast can promote cell repair and support the endogenous protection mechanism to fight against skin aging.

PuriBifido is created through the fermentation of composite bifidobacterium (commonly known as Bifida) groups. It is a bifidobacterium derivative that can completely improve skin states with the

Specification

Exterior Opaque light yellow fluid
Smell Slight featured acid smell
pH 4.0~6.0
Total solids ≥ 3.0 %
Nitrogen level 0.1~0.15%
Total amount of fungi ≤ 50 CFU/ml
Total amount of bacteria ≤ 300 CFU/ml
Heavy metal ≤ 40 ppm

Recommendation for use

Recommend dosage: 5.0~20.0%. An addition may be applied if required.

  • This product is a suspension, so there may be a few sediments after being left still for a long time, which is normal. Please shake it up before use.
  • It is recommended to add thickener in the prescription so as to prevent bacteria pieces from subsiding. The specific prescription shall be determined after testing.
  • Use it at the temperature lower than 60℃, and add it to the aqueous phase.
  • If this product is mixed with high-concentration alcohols, the flocculation precipitation will occur. The maximum allowable alcohol concentration is 30% according to the prescription.
  • If this product contacts a strongly acidic/alkaline environment, the flocculation precipitation and color change will occur. It should be avoided to directly add the product to such environment.