Category Archives: Platform Technology

Product Introduction: PuriActives® Ceramide E

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Product Introduction: PuriActives® Ceramide E

Advanced Biomimetic Lipid for Intensive Skin Barrier Restoration

1. Executive Overview: The Next Generation of Dermocosmetics

PuriActives® Ceramide E (INCI: Cetyl-PG Hydroxyethyl Palmitamide) represents a breakthrough in biomimetic lipid technology. Engineered specifically for the premium skincare and clinical dermocosmetics market, this high-purity pseudo-ceramide precisely replicates the structural geometry and biological function of human Ceramide Type 2.

By acting as the ultimate “intercellular cement,” it effectively fortifies the stratum corneum, restoring the skin’s primary defense system against modern environmental stressors.

2. The Science of Biomimicry: Mechanism of Action

Natural ceramides are easily depleted by aging, harsh surfactants, and environmental factors, leading to compromised skin barriers (e.g., Atopic Dermatitis, extreme dryness).

PuriActives® Ceramide E resolves this through advanced structural homology:

  • Intercalation: Its optimized molecular weight and lipophilic tail allow it to seamlessly intercalate into the existing lipid matrix of the skin.
  • TEWL Reduction: It physically seals the micro-fissures in the stratum corneum, dramatically reducing Transepidermal Water Loss (TEWL) and locking in endogenous moisture.
  • Barrier Reinforcement: Protects sensitive nerve endings from external irritants, instantly soothing reactive skin.

3. The Thermodynamic Advantage: Lamellar Phases

Beyond mere occlusion, PuriActives® Ceramide E is distinguished by its thermodynamic behavior in cosmetic formulations.

When co-emulsified with physiological lipids (cholesterol and free fatty acids), it self-assembles into highly ordered Liquid Crystalline Lamellar Phases.

  • Sustained Release: This multi-layered structure mimics healthy human sebum, offering long-lasting, sustained hydration rather than a temporary surface coating.
  • Elegant Skin-Feel: It delivers rich, intensive moisturization without the heavy, greasy tackiness traditionally associated with heavy ointments.

4. Formulation Excellence: The “Golden Ratio”

To unlock the maximum clinical efficacy of PuriActives® Ceramide E, our scientists recommend the biomimetic 3:1:1 Ratio (Ceramide : Cholesterol : Free Fatty Acid).

Application Versatility:

  • Face & Body Care: Barrier repair creams, anti-aging moisturizers, and soothing lotions for sensitive/eczema-prone skin (Use Level: 0.1% – 3.0%).
  • Advanced Hair Care: Deep conditioning masks and post-chemical treatment (bleaching/coloring) cuticle lipid replenishment.
  • Baby Care: Ultra-gentle, skin-identical protection for developing skin barriers.

5. Premium Quality & “Clean Label” Promise

Manufactured under the rigorous quality control standards of PuriPharm, this ingredient is designed for formulators targeting the “Clean Beauty” and high-end clinical segments.

  • 100% Preservative & Antioxidant Free: Eliminates the risk of sensitization from additive chemicals.
  • Exceptional Purity: Heavy metals meticulously controlled (≤10mg/kg), ensuring safety for the most sensitive dermatological applications.
  • Microbiological Superiority: Meets and exceeds stringent pharmacopeial-grade limits (Aerobic Plate Count ≤1000 CFU/g).
  • Proven Stability: Guaranteed shelf life of 36 months at room temperature (4~25℃), demonstrating robust chemical stability.

PuriPharm Co., Ltd. – Innovating at the intersection of biotechnology and dermatological science. Contact our technical team for custom formulation guidance and clinical data dossiers.

Innovative Formulation

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There is a growing number of biological active matters that face the problems such as being difficult to dissolve, unstability, being easy to be discolored, and low bio-availability during the development of new products.Continue reading→

Green Chemistry

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The goal of green chemistry is to reduce the impact of chemicals on human health with a dedicated sustainable prevention program, reduce or eliminate the use of chemicals and the production of hazardous substances in the design of chemical substances, thus effectively getting rid of environmental pollution.Continue reading→

Biotechnology

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Puripharm has established modern biotechnologies represented by the genetic engineering, metabolic engineering, protein engineering, fermentation engineering, biochemical extraction, etc.Continue reading→

Natural Phospholipid Nano Moisturizer

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Description: Natural Phospholipid Nano Moisturizer is a new type of moisturizing lotion developed with natural GMO-free soybean phospholipid, linseed oil, vitamin E and other natural materials under the modern nano-pharmaceutical technology. The average particle size of the product is less than 30nm. With its high transparency and sound stability, it can be applied to various formulations. Small size nanoparticles can have a good Occlusion Effect on our skin, enhancing the ability of moisture preserving of our skin. Phospholipid is one of the main components of human cells. It boasts great biocompatibility and fine skin texture, which provides a natural barrier for our skin against the invasion of external allergens such as microbe and dust particles so as to protect our skin from ultraviolet damage. The interaction between active substance in the formulation and the nano-sized oil dropletscan effectively improve the chemical stability of the product and promote the penetration of the active substance through the corneum into the deep part of our skin, giving full play of its functions and greatly enhancing the quality of the product.

Particles of different sizes interacting with our skin

Journal of Microencapsulation, 2011; 28(8): 709–716

The smaller the particle is, the stronger the adhesion effect is. The nanoparticles can have a good Occlusion Effect on the skin, which enhances the ability of moisture preserving of our skin.

Advanced Drug Delivery Reviews 59 (2007) 522–530

 

Distribution of product particle size

Moisturizing effect of different concentrations of nano moisturizer

Phospholipids (LP)  can effectively reduce skin erythema caused by ultraviolet radiation

Nano moisturizer can promote the absorption and transformation of delta-amino acid in MCF-7 cells

 

Nano moisturizer can promote the transdermal absorption and transformation of delta-amino acid

Nano Liposomal Vitamin E (NanoActive E)

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NanoActive E is a new type of vitamin E nanoliposome preparation (NanoLiposomal E).
Product Name: Nano Liposomal Vitamin E; Nanoactive Vitamin E; BioaActive Vitamin E; BioActive E; Nano Active E; Soluble Vitamin E CAS: 10191-41-0, 7695-91-2, 59-02-9

Description: Vitamin E is a fat-soluble vitamin, widely found in leaves, cereal oil and milk. It is a famous antioxidant and moisturizing ingredient and one of the essential components in the epidermis. Vitamin E can reduce the aging of tissue cells and the production of streak tissue, improve the effect of vitamin A, and prevent the oxidation of vitamin A and vitamin C. The external use of vitamin E has been proven to be effective in supplying vitamin E to the skin. However, pure vitamin E in cosmetic formulations is easily to be oxidized and is only oil soluble. Vitamin E wrapped in NanoActive is highly stable and soluble in water.

Features

  • NanoActive E is 100% water soluble and 100% oil soluble (amphiphilic) for a wide range of application.
  • NanoActive E greatly improves the stability and bioavailability of vitamin E
  • NanoActive E has good heat, pH and shear stability and is easy to use
  • NanoActive E is rich in active substance, which can be up to 20%
  • NanoActive E uses FDA GRAS grade materials for high safety
  • NanoActive E can increase the amount of vitamin E infiltrated into the depth of the epidermis while traditional oil-in-water emulsion loose vitamin E can only stay on the skin surface.

Efficacy:

  • NanoActive E effectively neutralizes free radicals, improves skin texture and reduces the appearance of wrinkles
  • NanoActive E can improve the stability of other active substances such as vitamin C in the product and promote the absorption of active substances by the skin.

Scope of application:

Eye care products, anti-aging products such as serum, eye mask, facial mask, skin care, etc.

Use: Add it at room temperature. You may heat it to above 40℃ to speed up the dissolution. Recommended dosage: 1-5%. Better effect with products containing NanoActive Q10.

Storage: Recommended to store it at 2-8°C

Packing specifications: 1kg, 5kg, 10kg

Recommended dosage: 0.5-5.0%