Category Archives: Anti-aging

Product Data Sheet: NanoActive Retinol

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Manufacturer：PuriPharm Co., Ltd.

Product Name：NanoActive Retinol

Product Category：Stable, Water-soluble, High-absorption Vitamin A

1. Product Description

NanoActive Retinol is a novel preparation developed using a proprietary nano-delivery system. With a particle size ranging between 20-30 nm, this system effectively stabilizes Retinol within nano-carriers. This technology ensures deep skin penetration for maximum efficacy, controlled release, and significantly reduced irritation compared to conventional retinoic acid.

2. Product Identification (INCI)

  • RETINOL (CAS #: 116-31-4)
  • PHOSPHOLIPIDS (CAS #: 123465-35-0)
  • CAPRYLIC/CAPRIC TRIGLYCERIDE (CAS #: 65381-09-1)
  • GLYCERIN (CAS #: 56-81-5)
  • WATER (CAS #: 7732-18-5)

3. Key Benefits & Efficacy

  • Anti-Aging & Anti-Wrinkle: Stimulates collagen and elastin production; increases epidermal thickness and elasticity.
  • Skin Renewal: Enhances cell turnover rate for smoother skin texture.
  • Brightening: Inhibits tyrosinase expression and melanin synthesis to reduce pigmentation and even skin tone.
  • Acne Care: Regulates sebum production and targets acne-causing bacteria (e.g., P. acnes).
  • High Stability & Safety: Significantly improves Retinol stability and minimizes the irritation typically associated with Vitamin A derivatives.
  • Enhanced Bioavailability: Nano-encapsulation ensures high absorption and effective penetration into skin layers.

4. Technical Specifications

4.1. Physical & Chemical Properties

4.2. Chemical Indexes

4.3. Microbiological Indexes

5. Application & Formulation Guidelines

  • Recommended Usage: 0.1% – 1.0%
  • Optimum pH Range: 4.5 – 8.0
  • Application Method: Add to the formula during the final stage of production.
  • Formulation Tips: * Primarily used in night care products.
  • For daytime products, photoprotective agents must be added.
  • Opaque packaging is highly recommended to protect the active ingredient.

6. Storage & Handling

  • Preservatives & Antioxidants: Free from added preservatives and antioxidants.
  • Storage Conditions: Store in original, unopened containers between and . Protect from direct sunlight and moisture.
  • Shelf Life: 12 months from the date of manufacture under recommended conditions.
  • Packaging: Standard plastic containers.

PuriPharm Co., Ltd.Address: 7th Floor, 6E Building, No. 1366 Hongfeng Road, Huzhou, Zhejiang, ChinaTel: 0572-2745768 | Email: service@puripharm.com

NanoActive® RAL (Liposomal Retinal) Advanced Vitamin A Technology for High-Performance Skin Care

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Company & Brand Background

PuriPharm Co. Ltd. is a science-driven company specializing in the research, development, and commercialization of high-performance functional bioactive ingredients. With a strong foundation in pharmaceutical science, biotechnology, and advanced formulation technologies, PuriPharm is dedicated to delivering safe, effective, and innovative active ingredient solutions for the global cosmetics, personal care, and biomedical industries.

PuriPharm operates two core product platforms:

• PuriActives® – a portfolio of high-quality functional bioactives derived from natural, bio-based, and scientifically validated sources.

• NanoActive® – an advanced nano-delivery ingredient platform designed to enhance the stability, bioavailability, and efficacy of sensitive active compounds through cutting-edge encapsulation technologies.

NanoActive® RAL (Liposomal Retinal) is a flagship product of the NanoActive® series, representing PuriPharm’s expertise in vitamin A chemistry, lipid delivery systems, and skin bioavailability optimization.

Retinal, also known as retinaldehyde (RAL), is a highly active form of vitamin A and a direct biochemical precursor of retinoic acid, the biologically active molecule responsible for many of vitamin A’s well-known skin benefits.

Unlike retinol, which requires a two-step enzymatic conversion process in the skin, retinal converts to retinoic acid in only one step. As a result, retinal delivers faster and more efficient biological activity at significantly lower concentrations.

Scientific and clinical studies have demonstrated that:

• Retinal converts to retinoic acid approximately 11 times faster than retinol

• Retinal offers efficacy comparable to retinoic acid but with significantly improved skin tolerance

• Retinal provides powerful anti-aging, skin-renewing, and collagen-stimulating effects with reduced irritation

For these reasons, retinal is widely recognized as one of the most advanced and effective vitamin A forms available for modern skin care formulations.

Why Choose Retinal Instead of Retinol?

Although retinol has long been used in cosmetic formulations, it presents several inherent limitations, including instability, oxidation, discoloration, and slow biological conversion.

Retinal offers distinct advantages:

• Faster efficacy – 11-fold faster conversion to retinoic acid compared with retinol

• Higher biological efficiency – closer to retinoic acid in the vitamin A metabolic pathway

• Improved skin tolerance – lower irritation potential compared with retinoic acid

• Broader functionality – supports anti-aging, acne control, skin tone improvement, and barrier repair

However, retinal itself is a chemically sensitive molecule that is prone to oxidation, light degradation, and discoloration. These challenges have historically limited its widespread use in cosmetic formulations.

NanoActive® RAL: Liposomal Retinal Technology

NanoActive® RAL overcomes the traditional limitations of retinal through an advanced liposomal nano-delivery system, enabling formulators to fully unlock the benefits of retinal in a stable, effective, and user-friendly form.

NanoActive® RAL is a lipid-encapsulated retinal, engineered using phospholipid bilayer technology that mimics the structure of biological cell membranes. This delivery system provides comprehensive protection and controlled release of retinal in the skin.

Key Features of NanoActive® RAL

• High stability – protected from oxidation, light exposure, and thermal degradation

• No discoloration – maintains formulation clarity and color stability over time

• Enhanced skin absorption – liposomal structure improves penetration and bioavailability

• Controlled release – gradual delivery minimizes irritation while maximizing efficacy

• Superior compatibility – easy to formulate into a wide range of cosmetic systems

Through nano-encapsulation, NanoActive® RAL ensures that retinal remains active, effective, and safe throughout the product’s shelf life and during skin application.

11 Times Faster Conversion to Retinoic Acid

One of the most important advantages of NanoActive® RAL is the intrinsic metabolic efficiency of retinal.

In the skin:

• Retinol → Retinal → Retinoic Acid (two-step conversion)

• Retinal → Retinoic Acid (one-step conversion)

This simplified pathway allows retinal to deliver results approximately 11 times faster than retinol, leading to quicker improvements in skin texture, tone, and visible signs of aging.

Because NanoActive® RAL enhances retinal delivery and stability, this rapid conversion can occur more efficiently and consistently within the skin.

Skin Benefits of NanoActive® RAL

NanoActive® RAL delivers a comprehensive range of clinically supported skin benefits:

Anti-Aging & Wrinkle Reduction

• Stimulates collagen and elastin synthesis

• Improves skin firmness, elasticity, and density

• Reduces the appearance of fine lines and wrinkles

Skin Renewal & Texture Improvement

• Accelerates epidermal cell turnover

• Smooths rough skin texture

• Promotes a more even and refined complexion

Brightening & Tone Correction

• Inhibits tyrosinase activity and melanin formation

• Enhances skin radiance and uniformity

• Helps fade hyperpigmentation and discoloration

Acne & Blemish Control

• Exhibits direct antibacterial activity against acne-causing bacteria

• Regulates sebum production

• Supports pore refinement and blemish recovery

Barrier Support & Repair

• Improves skin barrier integrity

• Enhances resilience against environmental stressors

• Supports long-term skin health and comfort

Superior Stability and Color Performance

Traditional retinal and retinol formulations often suffer from:

• Rapid degradation

• Yellowing or browning over time

• Loss of activity during storage

NanoActive® RAL is specifically designed to address these issues. The liposomal encapsulation effectively isolates retinal from environmental stress factors, resulting in:

• Excellent formulation stability

• Minimal color change over time

• Consistent performance throughout shelf life

This makes NanoActive® RAL ideal for premium skin care products where visual appearance, product consistency, and long-term efficacy are critical.

Easy Absorption & Skin Compatibility

The phospholipid-based nano-carriers used in NanoActive® RAL closely resemble the lipid structure of human skin. This biomimetic design allows for:

• Improved skin affinity

• Efficient penetration through the stratum corneum

• Targeted delivery to deeper skin layers

As a result, NanoActive® RAL is easily absorbed, non-greasy, and well tolerated, even in long-term use formulations.

NanoActive® RAL is suitable for a wide range of cosmetic and personal care applications, including:

• Anti-aging serums and creams

• Brightening and skin renewal products

• Acne treatment formulations

• Eye care products

• Barrier repair and post-treatment care

Its excellent compatibility allows formulators to incorporate NanoActive® RAL into emulsions, gels, lotions, and advanced delivery systems with ease.

A New Generation of Vitamin A Actives

By combining the proven biological power of retinal with state-of-the-art nano-delivery technology, NanoActive® RAL represents a new generation of vitamin A active ingredients.

It offers:

• Faster results than retinol

• Better tolerance than retinoic acid

• Greater stability than conventional retinal

• Enhanced user experience and formulation reliability

Conclusion

NanoActive® RAL (Liposomal Retinal) embodies PuriPharm Co. Ltd.’s commitment to scientific excellence, innovation, and performance. As a key product within the NanoActive® platform and a natural extension of the PuriActives® philosophy, NanoActive® RAL provides formulators and brands with a powerful, stable, and advanced vitamin A solution for next-generation skin care.

By delivering stable, non-discoloring, easily absorbed liposomal retinal with an 11-fold faster conversion to retinoic acid compared with retinol, NanoActive® RAL sets a new benchmark for efficacy, safety, and formulation sophistication in modern cosmetic science.

PuriActives®PuriVitin™

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The Global Hydration Challenge

What Consumers Really Expect

The Problem with Conventional Humectants

A New Hydration Strategy

From temporary surface moisturization…

To skin-identical, biomimetic hydration.

Introducing PuriVitin™

What Is PuriVitin™?

Origin & Sustainability

Science Insight: Saccharide Isomers

Mechanism of Action

Hydration That Stays

Short & Long-Term Benefits

Visible Skin Improvements

FACIAL COLOR MAPPING TECHNOLOGY

Makes PURIVITIN benefits visible

3-HOUR after single applicationof 1% PURIVITIN dry cheek area is already betterhydrated.

Used for 28-DAYS, 1% PENTAVITIN®brings tired, dry skin back to life.

3% PURIVITIN compared to placebo

Three hours after single application of3%PURIVITIN significant hydration boost of forehead, eye region and cheek area.

After twice daily application for 28 days of 3% PURIVITIN®, there is highly significant hydration power to all facial areas.

PURIVITIN Reverse the 5 symptoms of dehydrated skin: roughness,dullness, flakiness, tightness, redness

PURIVITIN Reverse the 5 symptoms of dehydrated skin: roughness,dullness, flakiness, tightness, redness

PREBIOTIC SCALP MODULATION

PURIVITIN Rebalances scalp microbiomeinteraction in vitro

PURIVITIN For a well balanced scalp microbiome interaction

Consumer-Relevant Benefits

Conceptual Comparison

Versatile Application Areas

Formulation Advantages

Dosage & Use Level

Clean Beauty & Market Fit

Why Partner with PuriActives®?

Bio-Skinflora Solution

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Description: nutrient solution with strong capacities of moisture retention, soothing allergies and anti-irritation

Innovative Mechanism:

Plant collagen, glucan and prebiotics work together to form a highly hydrophilic micro-ecological protective membrane on the skin, which protects, repairs and strengthens the first defensive line for skin.

With a strong hydrophilic feature, phytocollagen is a very good natural moisturizing ingredient. Unlike general covering moisturizer, Plant collagen can promote the keratinocytes of skin to produce a natural moisturizing factor (NMF), which exerts a moisturizing effect, penetrates and infiltrates the stratum corneum, making the skin more transparent and moisturized, and forming a skin self-protection mechanism. This will enhance skin elasticity, eliminate small wrinkles, improves the texture of skin, and isolates external toxic and harmful substances.

The natural water-soluble yeast β-glucan can bind to the receptor CR3 of yeast β-glucan on the Langerhans cells in the epidermis, activate macrophages, and produce various cytokines (e.g., IL-1, IL-6, GM-CSF), epidermal growth factor (EGF), tumor necrosis factor (TNF-α) and angiogenic factors (AF), etc., thus improving skinimmunity. Yeast glucan also has the function of anti-inflammation, anti-allergy, eliminating free radical, moisturizing and accelerating stratum corneum renewal, which helps the skin resist external mechanical and chemical stimuli and facilitates the recovery of injuries. An increase in epidermal growth factor can promote the production of collagen and elastin, thus improving the exterior of skin and eliminating fine line wrinkles.

Prebiotics promotes the growth of epidermal probiotics through selective nutrient supply mechanisms, inhibits the growth of harmful flora through competitive mechanisms, establishes and maintains a stable and healthy skin micro-ecological system, maintains healthy skin pH, and reduces inflammation and allergic reactions. .

 

 

 

 

 

 

 

Fermentation-derived Phytocollagen

 

 

 

 

 

 

 

 

 

Plant-derived Fructan and Fructose Oligomers

 

 

 

 

 

 

 

Yeast-derived Glucan

 

Prebiotics can improve skin micro-ecological balance

Applications:

  1. Sensitive skin: protecting the skin from external stimuli, soothing allergies and anti-inflammation
  2. Dry skin: moisturizing, wrinkle-reducing, anti-aging, improving skin texture
  3. Anti-acne&pimple: inhibiting the growth of harmful microbes such as propionibacterium acnes, promoting the growth of skin probiotics, establishing a healthy micro-ecological system, and regulating the pH value of skin health.
  4. Infant care: prevention on infection (especially for the areas wrapped with diaper)
  5. Other skincare and haircare products.

 

Instruction for Prescription

Solubility: This product is easily soluble in water

Recommended dosage: The product is added in an amount of 1-10%. It is recommended to add this below 60℃ in the final stage of cosmetic production. It is compatible with a wide range of cosmetic ingredients.

 

 

PuriBifido

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INCI Name :Bifida Ferment Lysate

Bifida Ferment Extract, Phenoxyethanol, Potassium Sorbate, Xanthan Gum

CAS No. None for now; 122-99-6; 24634-61-5; 11138-66-2

It is fermented by the compound bifidobacteria (known as bifidus yeast in the industry). It is a probiotic product that thoroughly improves the skin condition and can be classified as a skin micro-ecological active matter. The core ingredient of the Estee Lauder Advanced Night Repair is the bifidus yeast. The anti-ageing active ingredients extracted from the lysate of bifidobacteria through biotechnology can effectively protect skin, reduce the damage caused by ultraviolet rays to the skin, activate the immuno-suppressive process, stimulate endogenous skin protection, and promote cell repair. It can reduce skin spots, brighten the skin, reduce the number and degree of wrinkles, and smooth the skin. Bifidus yeast can promote cell repair and support the endogenous protection mechanism to fight against skin aging.

PuriBifido is created through the fermentation of composite bifidobacterium (commonly known as Bifida) groups. It is a bifidobacterium derivative that can completely improve skin states with the

Specification

Exterior Opaque light yellow fluid
Smell Slight featured acid smell
pH 4.0~6.0
Total solids ≥ 3.0 %
Nitrogen level 0.1~0.15%
Total amount of fungi ≤ 50 CFU/ml
Total amount of bacteria ≤ 300 CFU/ml
Heavy metal ≤ 40 ppm

Recommendation for use

Recommend dosage: 5.0~20.0%. An addition may be applied if required.

  • This product is a suspension, so there may be a few sediments after being left still for a long time, which is normal. Please shake it up before use.
  • It is recommended to add thickener in the prescription so as to prevent bacteria pieces from subsiding. The specific prescription shall be determined after testing.
  • Use it at the temperature lower than 60℃, and add it to the aqueous phase.
  • If this product is mixed with high-concentration alcohols, the flocculation precipitation will occur. The maximum allowable alcohol concentration is 30% according to the prescription.
  • If this product contacts a strongly acidic/alkaline environment, the flocculation precipitation and color change will occur. It should be avoided to directly add the product to such environment.

Nano Liposomal Vitamin A (NanoActive A)

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NanoActive A is a novel vitamin A nanoliposome preparation (NanoLiposomal A).
Product Name: Nano Liposomal Vitamin A: Nanoactive Vitamin A; BioaActive Vitamin A; BioActive VA; NanoActive VA; Soluble Vitamin A CAS: 79-81-2

Description: Vitamin A palmitate is a vitamin A derivative and a fat-soluble antioxidant. NanoActive A is water-soluble, transparent,highly effective and non-irritating vitamin A, which can repair cells and protect against UV-induced skin aging, promote the metabolism of epidermis and keratinocytes, facilitate and strengthen the exfoliation of keratinocytes and the growth of new cells, as well as the production of collagen and elastic fibers, while helping to maintain the normal metabolic cycle of cells.

Chemical structure of Vitamin A

Mechanism

 Features

  • NanoActive A uses FDA GRAS grade materials for high safety
  • NanoActive A is stable to heat, pH and shearing, so it is convenient to use.
  • NanoActive A is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.
  • NanoActive A greatly improves the stability and bioavailability of vitamin A

 

Efficacy:

  • NanoActive A has the ability to regulate the metabolism of the epidermis and stratum corneum, which can resist aging and wrinkle
  • NanoActive A relieves seborrhea and makes skin elastic, while diminishing spots and softening skin
  • NanoActive A helps protect the epidermis and mucous membranes from bacteria in order to maintain skin health
  • NanoActive A can improve the stability of other active matters in the product and facilitate absorption

Effectively increase skin elasticity

 

Use:Add it at room temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%. Metal ions such as iron ions must be avoided in the system. Better effect with products such as vitamin C and vitamin E.

Storage: Keep it away from light at a temperature below 25℃.

NanoActive RAL

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Nanoactive RAL, INCI name: Retinal, CAS: 116-31-4.

Product Name: Nanoactive RAL, BioaActive Retinaldehyde; BioActive Retinal; Soluble Retinal; Soluble Retinaldehyde;Nano Liposomal

Nanoactive RAL is a novel retinal nanoliposome formulation (NanoLiposomal RAL).

A new liposome preparation. RAL has the characteristics of retinoic acid in the skin, and is better tolerated than retinoic acid. It directly interacts with protein receptors in cells, stimulates epidermis to accelerate regeneration, increases the thickness of the stratum corneum, and makes the skin tighter and more orderly. It also accelerates the production of collagen in the dermis layer, prevents the damage of UV to collagen, inhibits the increase of MMP caused by UV, and makes the skin more elastic; the unique aldehyde-based structure has a very good effect on P. acnes, etc., and effectively improves acne skin. Large amounts of retinal, retinol, retinol retinate (15498-86-9), HPR(893412-73-2) and other Vitamin A kind products of pharmaceutical grade are available.

 

Description:

Retinaldehyde (RAL), also known as vitamin A aldehyde, is a derivative of retinol after oxidation. It is formed by oxidative cleavage of β-carotene. If  reduced, retinol can be attained; If oxidized, retinoic acid can be attained.Retinoic acid。”. The role of retinoic acid (Vitamin A) in skin diseaseis very extensive, but due to local irritation, its clinical application is limited to some extent.Retinaldehyde is an intermediate metabolite of natural retinoic acid and has similar biological activity as retinoic acid. But the skin is significantly more tolerant to retinoic acid.

The main forms of vitamin A and their interconversion

Retinal has many target on the skin. It can be used as a skin care product to produce a variety of effects such as anti-aging, skin rejuvenation, whitening, anti-wrinkle, acne, keratin, etc. It is an emerging high-efficiency natural active substance. Retinal is hardly soluble in water while easy to be oxidized and discolored, which limits its application in cosmetics. Nano actives with a particle size of less than 30 nm developed by nano-transmission system (NDS) enable retinals to be steadily wrapped in nano-carriers, greatly improving the absorption efficiency and bioavailability. This overcomes the original defects and maintain the advantages and enables a more convenient and wider range of uses.

Skin care effect

The large use of non-physiological doses of exogenous retinoic acid can cause an overload of the retinoic acid-dependent pathway in the skin, causing adverse reactions such as skin irritation. RAL is a natural metabolite of retinol and a direct precursor of retinoic acid, and it also has similar biological activity to retinoic acid. The advantage of RAL compared with retinoic acid is its multi-directional metabolism, that is, the excess RAL can be rapidly reduced to retinol, then stored and inactivated in the form of retinol, and this “reverse metabolism” is not present in retinoic acid. After it is absorbed by the skin, most of it is converted to retinol vinegar stored for slow release, and a small amount of RAL is oxidized to retinoic acid by keratinocytes in differentiation-dependent manner, while a very small amount of retinoic acid is can exert significant biological effects in cells. This can avoid skin adverse reactions caused by high doses of retinoic acid. Clinical observations also show that topical RAL creams are well tolerated compared with retinoic acid and can be applied to sensitive areas. The topical RAL cannot absorbed by human blood. The levels of various vitamin A acids in the blood also cannot be affected.

RAL needs to be activated by the conversion of enzymes in keratinocytes to retinoic acid, so RAL has similar biological activity as retinoic acid. One of the indicators of retinoic acid activity is to induce the expression of retinoic acid binding protein (CRABP-2) in cells. External RAL can evidently induce the expression of CRABP-2 mRNA and protein. The topical natural retinoic acidcan also induce the expression of nuclear receptor in retinoic acid . Like retinoic acid, RAL also functions to regulate cell proliferation and differentiation. It can increase epidermal DNA synthesis, increase epidermis thickness, induce 50kD keratin, and reduce 7OkD keratin mRNA expression. Inducing positive keratinization, reducing 65kD keratin mRNA expression, and increasing filaggrin and loricin mRNA expression. In addition, RAL is also involved in the regulation of neovascularization in the skin, inhibiting the production of vascular endothelial growth factor by keratinocytes. It can repair the elastic fibers and collagen damage induced by UVA. RAL is also capable of dissolving acne and the direct sterilizing effect towards propionibacterium acnes. Natural retinoic acid play an important role in epidermal differentiation, dermal remodeling and curing skin inflammation. Retinaldehyde as an important intermediate metabolite of natural retinoic acid has both biological activity similar to that of retinoic acid and is well tolerated by the skin, thus it is given wider application in cosmetics.

Retinaldehyde can repair elastic fiber and collagen loss caused by UV:

Retinaldehyde prevents skin aging caused by ultrasound and fluid

technology:

 

Retinaldehyde can effectively improve skin photoaging symptoms:

 

 

Retinaldehyde and retinal are well tolerated, while retinoic acid is more irritating

Retinaldehyde can effectively inhibit epidermal melanin

Features

  • NanoActive Retinaldehyde uses FDA GRAS grade materials for high safety
  • NanoActive Retinaldehyde has good heat, pH and sheer stability and is easy to use.
  • NanoActive Retinaldehydegreatly enhances the stability and bioavailability of retinal
  • NanoActive Retinaldehyde can improve the stability of other active matters in the product and facilitate absorption
  • NanoActive Retinaldehyde is 100% water soluble and 100% oil soluble, allowing a wide range of uses.

 

Applications

  • Wrinkle repairing: promote collagen and hyaluronic acid synthesis, increase skin thickness and elasticity, repair the wrinkle and firm the skin.
  • Whitening and freckle removing: inhibit melanin synthesis, reduce pigmentation, whiten the skin and remove the freckle.
  • Anti-aging: anti-oxidation, anti-skin-aging
  • Skin-refreshing: renewal of keratin, refresh the skin.
  • Acne Treatment: sterilizing propionibacterium acnes and streptococcus, etc., treating acne and removing acne marks
  • Curing of skin photoaging

 

 Use: Add it at room temperature; recommended dosage: 1-5% The optimum pH range of the system is 3.0-6.5, and the finished product should avoid direct exposure to sunlight (using opaque packaging). It is recommended to add UV absorber to day care products.

 

Storage: keep it away from light at a temperature below 25℃.

 

Nano-Lipoic Acid (NanoActive ALA)

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Nanoactive ALA is a new type of lipoic acid nanoliposome preparation (NanoLiposomal ALA).
Product Name: Nano Liposomal ALA; Nanoactive ALA; BioaActive ALA; BioActive Alpha lipoic acid; NanoActive Alpha lipoic acid; Soluble alpha lipoic acid; Soluble ALA CAS: 62-46-4

Description: Alpha lipoic acid is an enzyme existing in mitochondria, which is similar to vitamins and can  eliminate free radicals that accelerate aging and cause disease. Lipoic acid has both fat-soluble and water-soluble properties, so it can pass through the entire body and reach every cell, providing comprehensive performance for human body. It is an all-purpose antioxidant with fat solubility and water solubility. Lipoic acid has the antioxidant effects 400 times greater than that of vitamins C and E, and it can greatly enhance the effects of vitamins C and E. Also, its efficacy lasts longer than other antioxidants. Smaller than the molecules of vitamin E, it can be easily absorbed by the skin and be effective in beautifying, activating cells and facilitating hair growth. Lipoic acid is effective in removing dark eye circles, wrinkles and spots. In addition, it enhances metabolism, improving the body’s blood circulation, so that skill will no longer be dull and the appearance or pores will be minimized, making your skin enviously firm and delicate. Therefore, lipoic acid is also an anti-aging nutrient that ranks the first place in the United States, which ties with ALA. The lipoic acid nanoactive material with particle size less than 30nm developed by nano-transmission system (NDS) completely solves the problem of solubility, and allows lipoic acid to be stably encapsulated in nano-carriers, which can greatly increase its absorption efficiency and bioavailability.

Lipoic acid’s structure

 

 

Lipoic acid is an powerful versatile anti-oxidant that can regenerates other antioxidants.

 

Lipoic acid (LA) target against skin aging

Features

  • NanoActive ALA uses FDA GRAS grade materials for high safety.
  • NanoActive ALA has good heat, pH and shear stability and is easy to use
  • NanoActive ALA greatly improves ALA’s stability and bioavailability
  • NanoActive ALA improves the stability and absorption of other actives in the product.
  • NanoActive ALA is 100% water soluble and 100% oil soluble (amphiphilic) for a wide range of applications.

 

Efficacy

  • NanoActive ALA can enhance the anti-oxidation effect of skin cells, reduce the damage from free radicals to the skin, significantly reduce skin roughness, eliminate freckles and reduce the appearance of fine lines.
  • NanoActive ALA is an active functional ingredient that is effective in anti-wrinkles, whitening, anti-aging, moisturizing and increasing skin elasticity.
  • It helps to enhance the efficacy of antioxidants such as polyphenols and kinetin, and also reduces the endogenous antioxidants.

   Use: Add it at room temperature. You may heat it to above 40 °C to speed up its dissolution, Recommended dosage: 1-3%. Better effect with products containing lipoic acid.

Storage: Keep it away from light at a temperature below 25°C.

 

 

Experimental proof

Effect of lipoic acid on cell activity

Lipoic acid’s whitening effect

Lipoic acid’s anti-wrinkle effect