NanoActive RETINAMIDE is an innovative ingredient that combines the anti-aging benefits of retinamide with the advantages of nano-technology, designed to enhance skin penetration, stability, and bioavailability.
Below is a detailed introduction to NanoActive RETINAMIDE:
- Chemical Characteristics
NanoActive RETINAMIDE is a derivative of retinamide, created by conjugating retinoic acid with polyethylene glycol (PEG) to form a polyethoxylated retinoic acid. This structure significantly improves its water solubility, stability and skin permeability while reducing irritation and degradation potential.
- Functions and Benefits
2.1 Anti-Aging Effects
- Promotes Collagen Synthesis:
NanoActive RETINAMIDE significantly increases collagen synthesis in the skin, reducing the appearance of wrinkles and fine lines.
- Reduces Elastin Degradation: By inhibiting the breakdown of elastin, it improves skin elasticity, making the skin firmer.
- Antioxidant Properties: It has antioxidant properties that combat free radical damage, delaying skin aging.
2.2 Skin Permeability
- NanoActive RETINAMIDE, through nano-encapsulation technology, significantly enhances skin absorption. Studies have shown that its skin permeability is several times higher than that of traditional retinol and retinyl palmitate.
- Its hydrophilic nature allows it to easily penetrate the skin barrier, reaching deeper skin layers to deliver anti-aging benefits.
2.3 Stability
- Amide Stability: To create a stable retinoic acid molecule, an amide condensation process is employed. In this chemical process, two molecules combine to form a new compound, creating a strong and highly stable bond known as an amide bond. This newly formed bond acts like a powerful adhesive, enhancing the stability of the original component. The amide structure inRETINAMIDE is highly stable and does not hydrolyze like retinoate (e.g., hydroxypinacolone retinoate, HPR), which can gradually convert to prohibited retinoic acid during the shelf life of cosmetic products. This makes NanoActive RETINAMIDE a safer and more stable alternative for long-term use.
- Environmental Stability: NanoActive RETINAMIDE exhibits higher stability under conditions of light, oxygen, and high temperatures, solving the problem of traditional retinamide being prone to degradation.
- Formulation Stability: In O/W emulsions, it shows superior stability compared to retinol and retinyl palmitate, making it ideal for various cosmetic formulations.
- Contribution of Polyethylene Glycol (PEG):
PEG significantly enhances the stability and skin permeability of PuriActives® Liposomal RETINAMIDE. The hydrophilic nature of PEG makes the compound more soluble in water and easier to absorb into the skin, while also protecting the molecule from oxidation and degradation. This results in a more stable and effective product that can be conveniently used during the day.
2.4 Safety
- NanoActive RETINAMIDE has demonstrated excellent safety in various toxicological tests, with no irritation or sensitization, making it suitable for long-term use.
- It has passed allergy and skin irritation tests, proving to be gentle on the skin without causing redness or irritation.
- Combination with PuriActives®FastCalmin: Combined with the patented formula PuriActives®FastCalmin, it effectively prevents adverse reactions commonly associated with retinol-based ingredients, providing enhanced safety and tolerability.
- Applications
3.1 Core Anti-Aging Applications
- Anti-Wrinkle Serums– For reducing the appearance of wrinkles and fine lines.
- Firming Creams– To enhance skin elasticity and reduce sagging.
- Whitening Products– By promoting collagen synthesis, it helps to even out skin tone.
- Sunscreen and Repair Products– Enhances the skin’s self-repair ability and reduces photo-aging damage.
3.2 Additional Applications Based on Tretinoin Clinical Efficacy
All listed benefits are enabled by the ingredient’s high permeability, low irritation profile, and daylight stability.
| Indication | Mechanism of Action | Suitable Product Forms |
| Acne vulgaris (comedonal & inflammatory) | Regulates follicular keratinization, suppresses sebum production, exerts anti-inflammatory effects. | Spot gels, oil-control serums, overnight blemish patches. |
| Keratosis pilaris (chicken skin) | Accelerates desquamation of hyper-keratotic follicular plugs, smoothes rough texture. | Body lotions with 5–8 % urea + 1 % NanoActive RETINAMIDE |
| Mild-to-moderate plaque psoriasis | Inhibits epidermal hyper-proliferation, restores orderly differentiation. | Calming repair creams, scalp lotions under occlusion. |
| Flat warts / HPV lesions | Induces keratinocyte apoptosis, activates local immunity, assists wart clearance. | Post-cryotherapy repair gels, low-irritation keratolytic pens. |
| Hyper-pigmentation (melasma, post-inflammatory marks) | Inhibits melanosome transfer, accelerates epidermal turnover, fades discoloration. | Intensive pigment-correct serums, post-laser spot correctors. |
| Photo-damage / actinic keratosis field therapy | Repairs UV-induced collagen fragmentation, reduces actinic keratosis count. | Antioxidant day creams with SPF, dermatologist-supervised field sprays. |
| Ichthyosis & disorders of cornification | Corrects defective desquamation, replenishes intercellular lipids. | High-occlusion ointments for extremities, pediatric-friendly lotions. |
| Post-procedure maintenance (laser, microneedling, chemical peel) | Enhances re-epithelialization and collagen remodeling while minimizing retinoid irritation. | Barrier-repair creams introduced 48 h post-procedure. |
- Usage Recommendations
- Formulation Suggestions– Typically used in nighttime skincare products to avoid light exposure; daylight use is possible when combined with broad-spectrum SPF.
- Recommended Concentration– 1–5 %, adjustable according to product positioning.
- Packaging Suggestions– Use opaque, airless dispensers to protect from light and oxidation.
- Market Positioning
- High Efficiency– Significantly outperforms traditional retinol and retinyl palmitate.
- Safety– Non-irritating and suitable for sensitive skin.
- Innovation– Combines nano-technology to provide a better user experience and effectiveness.
- Clinical Research Support
The anti-aging effects and safety of NanoActive RETINAMIDE are supported by multiple clinical studies. Research shows that it performs exceptionally well in promoting collagen synthesis, reducing wrinkles, and improving skin elasticity, with excellent tolerance and low irritation.
- Company Information
PuriPharm Co. Ltd. is a high-tech biopharmaceutical enterprise specializing in the development of functional active raw materials and nano-biological drugs. It is technology-driven and market-oriented, committed to the beauty and health sector. Based on platform technologies such as green chemistry, synthetic biology, nano-encapsulation, and plant extraction, a series of active products have been developed, which can be used in fields such as medicine, functional cosmetics, and food.