Press Release in English

PuriPharm Co. Ltd. and Kunming Medical University Collaborate to Achieve Breakthrough in Antidepressant ResearchNovel Nano-Formulation Technology Enhances Efficacy of Tetrahydrocurcumin PuriPharm Co. Ltd. recently announced a significant research breakthrough in collaboration with Associate Professor Guo Ying’s team from the Department of Pharmacology, Kunming Medical University. The study confirms that PuriPharm’s proprietary nano-tetrahydrocurcumin (THCN) demonstrates superior efficacy in improving lipopolysaccharide (LPS)-induced depressive-like behaviors and neuroprotection in mice compared to traditional tetrahydrocurcumin (THC). The findings were published in Acta Universitatis Medicinalis Anhui. Research Highlights ·Enhanced Therapeutic Efficacy: THCN, developed using PuriPharm’s advanced nano-formulation technology, showed superior anti-anxiety effects in long-term administration compared to THC. ·Dual Neuroprotective Mechanisms: THCN alleviated prefrontal cortex demyelination by promoting GFAP expression, while THC mainly exerted its effects through TLR4 pathway inhibition. ·Improved Stability and Bioavailability: The nano-formulation optimized drug delivery, enabling sustained efficacy at a lower dose (10 mg/kg), a critical step toward clinical translation. Technology Value and Collaboration PuriPharm’s nano-formulation platform addresses challenges such as poor solubility and low stability of natural compounds. This collaboration underscores the potential of interdisciplinary research in advancing novel antidepressant therapies. “Our partnership highlights the power of industry-academia collaboration,” said Associate Professor Guo Ying. “THCN offers a promising new approach for depression treatment, and we look forward to further clinical development.” About PuriPharm Co. Ltd. PuriPharm specializes in nanomedicine and innovative drug delivery systems, committed to translating cutting-edge science into clinical solutions. With a focus on oncology and neurological disorders, the company leverages its expertise in nanotechnology to develop next-generation therapeutics. Media Contact PuriPharm Co. Ltd.  Email: service@puripharm.com Website: www.puriactives.com

Pionin, INCI name: Quaternium-73., CAS: 15763-48-1.

It is a kind of yellow odorless crystalline powder, an acne inhibitor with antibacterial activity that can be used as a preservative with a strong ability to kill bacteria, Staphylococcus, E. coli, etc., and has a antiseptic property better than parabens. It can also inhibit melanin production. Clinical studies have shown that its MIC for P. acnes is 0.00002%, and the rash can be reduced by 50% after two weeks of use. 0.1ppm of dosage can completely inhibit the formation of melanin, which is better than kojic acid. It is highly safe with good heat and light stability and pH stable between 5.5 to 8.0. Low required dosage makes it very cost-effective. Purinin has strong antibacterial and anti-melanin effects and is effective even in low dosage.

Scar-Zero is a new scar repair product that can effectively prevent and treat skin scars. With advanced genomics and proteomics technology, the product is manufactured by extracting core factors related to skin repair in human proteins through the online activity screening technology and genetic recombination technology. Various factors cooperate and restrict each other, forming a complex regulatory network, regulating cells to maintain normal oxidative stress levels, and controlling micro-inflammation in the skin. It guides the proliferation of epidermal and dermal cells, and prolongs the self-regenerating function of keratinocytes to fundamentally reverse the aging process of skin cells. The unique repair factor can help the skin produce a large number of active matters, effectively control the micro-inflammation in the skin, repair blood vessels and dermal cells, make the skin hydrated and translucent, and improve the skin gloss, softness and tenderness to render an effect of inverse age.

NanoActive CBD, INCI: CANNABIS SATIVA LEAF EXTRACT（Hemp leaf extract）， CAS: 13956-29-1.

A new liposome-encapsulated preparation with good water solubility, compatibility and stability which is easy to absorb. CBD works by inhibiting (FAAH) and increasing the content of ECS(endocannabinoid system). It has the effect of sedative, soothing, analgesic, antipruritic, repair, anti-aging, anti-wrinkle, anti-inflammation, sterilization, anti-acne (especially suitable for oily acne skin; better effect if used with NanoActive r-Retinoate), and inhibiting excessive secretion of sebum. Studies have shown that cannabinoids have important medicinal value for skin diseases. Hemp leaf extract can significantly reduce skin inflammation and regulate skin immune function, and has a good therapeutic effect on non-specific dermatitis, itching, rosacea and other skin diseases.

NanoActive HPR, INCI name: Hydroxyl pinacone retinoate, CAS: 893412-73-2.

A new nano-liposomal preparation which can be absorbed better. HPR is a retinol derivative that can directly bind to cellular RARs. It has the function of regulating the metabolism of the epidermis and stratum corneum. It has anti-ageing effects, reduces sebum spillage, dilutes epidermal pigments to prevents skin aging, treats acne, and whitens skin spots. Besides the powerful effect of retinoic acid, it greatly reduces its irritation. It is mainly used for anti-aging, wrinkle prevention and acne recurrence prevention. NanoActive r-Retinoate (retinol retinate, 15498-86-9), as a vitamin A ester, has milder and less irritating properties than retinol and thus can be effectively used in anti-aging and wrinkle removing skin care products.

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