PuriActives® Ursolene™ BZ (Benzyl Ursolate)

Posted on 05/12/202605/12/2026 by L, Y

Precision-Engineered Triterpenoid: The Cornerstone of Deep Dermal Rejuvenation & Structural Reconstruction

1. Product Overview

While natural pentacyclic triterpenes (like Ursolic Acid) are renowned for their exceptional biological activities, their cosmetic application has historically been bottlenecked by extremely poor lipophilicity, low skin penetration, and formulation instability (propensity to crystallize).

Enter PuriActives® Ursolene™ BZ (INCI: Benzyl Ursolate). By introducing a benzyl group to the ursolic acid backbone, we have fundamentally shifted the molecule’s partition coefficient ( log P). This precise structural modification transforms a traditional botanical extract into a highly bioavailable, oil-soluble powerhouse. It precisely targets the Extracellular Matrix (ECM) architecture, offering a definitive solution for intrinsic/extrinsic aging, loss of elasticity, and compromised skin barriers.

The Core Edge: The perfect synergy of a naturally derived core and rational structural design, bridging the gap between pharmaceutical-grade precision and cosmetic applicability.

2. Key Biological Pathways & Mechanism of Action

PuriActives® Ursolene™ BZ operates through a multi-target mechanism, mitigating tissue senescence at the cellular level:

MMP Modulation & ECM Protection: Acts as a potent competitive inhibitor of Matrix Metalloproteinases (specifically MMP-1 and MMP-9), halting the enzymatic degradation cascade of collagen and elastin networks.

Fibroblast Activation via TGF-β Pathway: Stimulates the transforming growth factor-beta (TGF-β) signaling pathway, upregulating COL1A1 and COL3A1 gene expression to drive the de novo synthesis of structural proteins.

Inflammaging Mitigation: Suppresses the cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) pathways, interrupting the chronic micro-inflammatory cascades that accelerate tissue aging.

Epidermal Lipid Biosynthesis: Upregulates serine palmitoyltransferase (SPT) activity, driving endogenous ceramide production to fortify the stratum corneum barrier.

3. Proven Efficacy (In Vitro & In Vivo Highlights)

Our rigorous efficacy testing matrix demonstrates statistically significant improvements compared to vehicle and unmodified free ursolic acid controls.

In Vitro: Dermal Architecture Support

+ 42% Increase in Pro-collagen I synthesis (Primary human fibroblasts, at 10μM, ).
– 65% Reduction in UV-induced elastase activity, effectively preserving skin recoil capacity.

In Vivo Clinical Study: Facial Micro-Topography (28-Day Study)

A double-blind, placebo-controlled clinical study on 30 female volunteers (aged 45-65), applying a 0.2% PuriActives® Ursolene™ BZ cream twice daily.

● Wrinkle Depth (Ra): Significant reduction of 21.4% in the periocular region.

● Skin Density: Ultrasound imaging revealed a +15% increase in dermal echogenicity, indicating structural redensification of the dermis.

4. Formulation & Technical Guidelines

PuriActives® Ursolene™ BZ is engineered for the ultimate formulator experience. Its esterified structure completely circumvents the notorious crystallization issues of free ursolic acid, enabling the creation of highly stable, cosmetically elegant emulsions.

● INCI Name: Benzyl Ursolate

● Appearance: White to off-white crystalline powder

● Solubility: Soluble in cosmetic esters (e.g., Caprylic/Capric Triglyceride, Squalane), ethanol, and glycols. Insoluble in water.

● Recommended Usage Level: 0.05% – 0.30%

● Formulation Integration: Add to the heated oil phase ( 70~80℃ ) and stir until fully dissolved before emulsification.

● Optimal pH Range: 4.5 – 6.5

5. Sustainability & Purity

PuriActives® Ursolene™ BZ is derived from upcycled apple pomace and rosemary extract precursors, synthesized via a highly efficient, atom-economical esterification process. We guarantee an ultra-high purity active (HPLC ＞ 95%) while minimizing our environmental footprint.

Recommended Applications:

● Premium Anti-Aging Night Creams

● Intensive Barrier Repair Serums

● Dermo-cosmetics (Post-Procedure Care)

● Sun Recovery & “Anti-Inflammaging” Formulations

NanoActive DHM

Posted on 05/10/202605/10/2026 by L, Y

NanoActive DHM Epigenetic Youth Restorer & DNA Methylation Inhibitor

1. PRODUCT IDENTIFICATION

Product Name: NanoActive DHM
Trade Name: NanoActive DHM by PuriPharm
INCI Name: Water, Glycerin, Caprylic/Capric Triglyceride, Ampelopsis Grossedentata Extract, Phospholipids, Tocopheryl Acetate.
Botanical Source of Active: Ampelopsis grossedentata(Vine Tea)
Active Content: 9.5% – 10.5% (Ampelopsis Grossedentata Extract)

2. PRODUCT DESCRIPTION

NanoActive DHM represents a paradigm shift in epigenetic anti-aging. Developed by PuriPharm Co. Ltd., it is the industry’s first cosmetically viable DNA methylation inhibitor. Utilizing advanced nanoliposomal technology, highly purified Dihydromyricetin (DHM) is encapsulated in a biomimetic phospholipid bilayer. This sophisticated delivery system overcomes the inherent instability and poor skin penetration of DHM, allowing for targeted delivery to the deep epidermis and dermis, fundamentally reversing cellular aging at the genetic transcription level.

3. MECHANISM OF ACTION

Environmental stressors (UV, pollution) and intrinsic aging lead to hypermethylation of DNA, which functionally “silences” essential youth and structural genes.

Epigenetic Reversal: NanoActive DHM acts as a potent DNA methylation inhibitor, effectively removing age-induced methyl tags.
Gene Reactivation: By modulating over 10,000 methylation sites, it reactivates silenced genes associated with the Extracellular Matrix (ECM), signal transduction, and autophagy.
Targeted Delivery: The 50-150 nm liposomal spheres ensure enhanced transdermal absorption and a sustained-release profile, maximizing biological availability and minimizing potential irritation.

4. TECHNICAL SPECIFICATIONS

5. EFFICACY & CLINICAL DATA SUMMARY

Transcriptomic Upregulation: Significantly upregulates key structural genes including COL6A1 (Collagen Type VI), ITGB6, ITGA5, and VCL, restoring cellular anchorage and tissue firmness.
3D Skin Equivalent Model: In a 6-week in vitrostudy utilizing 20µM DHM on mature 3D skin models, NanoActive DHM effectively reversed epidermal thinning. Epidermal thickness increased from 30µm (untreated mature control) to ~50µm, closely mirroring the baseline of young skin models (60µm). Statistical significance achieved (p = 0.00064).

6. FORMULATION GUIDELINES

NanoActive DHM is designed for ease of use in premium cosmetic formulations.

Recommended Usage Level: 1.0% – 5.0%
Incorporation Phase: Add to the aqueous phase or during the cooling phase (below 45°C) for emulsions to maintain liposomal integrity.
pH Compatibility: Stable within a final formulation pH range of 4.5 – 7.5.
Incompatibilities: Avoid high concentrations of strong ionic surfactants or extreme ethanol levels (>20%) which may disrupt the lipid bilayer.
Processability: Do not subject to intense, prolonged shear force (homogenization > 3000 rpm for extended periods) after incorporation.

7. TARGET APPLICATIONS

Premium Anti-Aging Skincare: Serums, night creams, and eye treatments targeting chronological aging and photoaging.
Medical Aesthetics Post-Care: Restorative formulations designed to prolong the effects of clinical treatments by maintaining epigenetic cellular health.
Preventative Aging: Solutions targeting millennials/Gen-Z exposed to urban pollution, stress, and lifestyle-induced epigenetic damage.

8. STORAGE & SHELF LIFE

Storage Conditions: Store in a cool, dry place away from direct sunlight. Recommended storage temperature: 4°C – 25°C. Do not freeze. Keep containers tightly sealed when not in use.
Shelf Life: 24 months from the date of manufacture under optimal storage conditions.

Disclaimer: The information provided herein is based on our current knowledge and rigorous scientific testing. It is intended for informational purposes for cosmetic professionals and formulators. It is the responsibility of the formulator to ensure the stability, safety, and regulatory compliance of the final consumer product.

PuriPharm Co. Ltd.Pioneering Epigenetic Skincare SolutionsWebsite: www.puriactives.com | Email: service@puripharm.com

NanoActive DHM

Posted on 05/06/202605/06/2026 by L, Y

Scientific Breakthrough: Epigenetic Anti-AgingDeveloped byPuriPharmCo. Ltd.

1. Epigenetics and Skin Aging

What is Epigenetics?

Epigenetics is the science studying how lifestyle and environmental factors influence gene expression.

This process occurs without changing the underlying DNA sequence.

Instead, it alters gene activity by turning genes “on” or “off” based on external stimuli.

It provides a profound new target for anti-aging interventions by addressing the root causes of cellular decline.

The Identical Twins Study

Primary Drivers of Skin Aging

The Process of DNA Methylation

Lifestyle and environmental factors influence gene expression primarily through DNA methylation.

Methyl groups (epigenetic factors) attach to the DNA molecule.

These methylation marks can activate or, more commonly in aging, improperly repress or “silence” specific genes.

This makes the DNA inaccessible to the machinery that keeps cells youthful and functional.

Hypermethylation and Aging

2. The DHM Breakthrough

Introducing Dihydromyricetin: The world’s first cosmetic DNA methylation inhibitor.

A Global Innovation

Dihydromyricetin (DHM)：

NanoActive DHM features Dihydromyricetin, globally recognized as the first cosmetic ingredient scientifically proven to inhibit DNA methylation. This represents a paradigm shift, leading a completely new direction in epigenetic anti-aging interventions.

Mechanism of Action

Inhibit Methylation: DHM acts directly at the genetic level to regulate and inhibit the excessive DNA methylation patterns that accumulate over time.

Reactivate Youth Genes: By removing these inhibitory methyl tags, DHM successfully reactivates silenced youth genes.

Restore Vitality: This fundamentally delays cellular aging by returning skin cells to their peak functional state, rather than just treating surface symptoms.

Natural Plant Source

NanoActive DHM is extracted exclusively from Ampelopsis Grossedentata, commonly known as Vine Tea.

It belongs to the Vitaceae family, Ampelopsis genus.

This specific plant is exceptionally rich in naturally occurring Dihydromyricetin.

It provides a clean, sustainable, and highly potent botanical source for epigenetic anti-aging formulations.

Cultivation & Extraction

3. Advanced Nanoliposome Technology

Nanoliposome Principles

Definition: Nanoliposomes are microscopic vesicles composed of phospholipid bilayers that perfectly mimic the human cell membrane structure.

Average Size: Ranging from 10 to 50 nm, they are perfectly sized to penetrate the skin barrier effectively.

Encapsulation: They possess a high drug entrapment efficiency, capable of securely encapsulating both hydrophobic and hydrophilic active ingredients like DHM.

Technology Advantages

The Dual Breakthrough

4. Clinical Efficacy and Validation

DNA Methylation Impact

Reversing the Clock

Under experimental conditions (20µM DHM over 6 weeks on a skin equivalent model), DHM treatment significantly affected over 10,000 methylation sites. It successfully induced a young epidermal DNA methylation pattern, restoring youthful epigenetic characteristics.

Epidermal Structure Improvement

Reactivation of Youth Genes

5. Market Application & Value

Competitive Advantage

Target Market & Applications

NanoActive™ DCP Advanced Liposomal Dimethylmethoxy Chromanyl Palmitate

Posted on 05/02/202605/02/2026 by L, Y

Next-Generation Targeted Delivery for Flawless, Radiant Skin

Product Overview

In the pursuit of safe and highly effective skin depigmentation, the delivery system is just as crucial as the active molecule itself. NanoActive™ DCP represents a paradigm shift in cosmetic skin brightening. By encapsulating the potent, photo-protective brightening agent—Dimethylmethoxy Chromanyl Palmitate—within an advanced nanoscale liposomal carrier, we have solved the traditional challenges of cutaneous penetration and active stability.

Designed for premium anti-aging and skin-illuminating formulations, this branded ingredient offers unparalleled bioavailability. It delivers the active compound precisely to the basal layer where melanocytes reside, unleashing peak biological activity at the nanoscale (the NanoActive™ advantage).

Technical Identity

Trade Name: NanoActive™ DCP
INCI Name: Water (and) Glycerin (and) Phospholipids (and) Dimethylmethoxy Chromanyl Palmitate
Appearance: Translucent to clear pale yellow liquid
Solubility: Water-dispersible
Recommended Usage Level: 1.0% – 5.0%

The Science: Mechanism of Action

Our proprietary liposomal technology bridges the gap between biological potential and clinical efficacy through a dual-action mechanism:

1. The Active: Precision Tyrosinase Inhibition

At the core of NanoActive™ DCP is Dimethylmethoxy Chromanyl Palmitate, a clinically validated, non-cytotoxic molecule that effectively inhibits human tyrosinase—the rate-limiting enzyme in melanogenesis. Unlike traditional agents like Hydroquinone, it exhibits no cellular toxicity and offers a significant photo-protective effect against UV-induced cellular damage, preventing premature photo-aging while correcting hyperpigmentation.

2. The Vector: Liposomal Transdermal Delivery

The human stratum corneum is a formidable barrier to hydrophobic molecules. Our advanced liposomes, composed of biocompatible phospholipids, mimic the skin’s natural lipid bilayer.

Enhanced Penetration: The nanoscale vesicles effortlessly fuse with the cellular membranes of the epidermis, facilitating deep tissue penetration.
Sustained Release: The liposomal matrix provides a controlled, time-released effect, maintaining optimal active concentrations at the target site over an extended period.
Superior Stability: Encapsulation protects the active core from oxidation and formulation incompatibilities, ensuring maximum potency from the laboratory to the consumer.

Key Formulator Benefits & Claims

Clean Beauty Compliant & Self-Preserving: Formulated entirely without conventional preservatives, this ingredient leverages an optimized, low-water-activity matrix for inherent microbiological stability. It perfectly aligns with strict “Clean Label” standards (e.g., Credo, Sephora Clean), reducing regulatory hurdles and formulation complexity for brand owners.
Perfect Clear-System Compatibility: Perfectly compatible with clear aqueous formulations. Its precise nanoscale dimensions evade Mie scattering, enabling the creation of completely transparent serums, high-performance toners, and ampoules without introducing turbidity.
Exceptional Thermodynamic Stability: Engineered for extreme resilience. NanoActive™ DCP withstands rigorous Freeze-Thaw Cycle Tests without demulsification, phase separation, or significant particle size growth, guaranteeing robust shelf-life and global supply chain reliability.
Visible Brightening & Tone Evening: Significantly reduces the appearance of age spots, melasma, and post-inflammatory hyperpigmentation (PIH).
Photo-Protection & Anti-Aging: Fights reactive oxygen species (ROS) and protects cells from UV-mediated damage.
Unmatched Safety Profile: Non-irritating, non-sensitizing, and free from the cytotoxic side effects associated with conventional lightening agents.
Formulation Elegance: Easy to incorporate into aqueous phases at the end of the manufacturing process (cold processable).

Cosmetic Applications

Ideal for premium dermatological and cosmetic formulations aimed at global skin tone improvement:

Intensive Brightening Serums & Essences
Clear Aqueous Toners and Micellar Waters
Anti-Dark Spot Targeted Treatments
Daily Radiance Creams and Lotions
Anti-Aging & Photo-Protection Formulations

Formulation Guidelines

Incorporation: Add to the cooling phase of emulsions (below 40°C) or directly into the aqueous phase of gels and serums under gentle stirring.
pH Stability: Optimal performance within a pH range of 4.5 to 7.0.
Compatibility: Compatible with most cosmetic ingredients; avoid high shear forces post-addition to maintain liposome integrity. Excellent suitability for clear or transparent formulations.

Disclaimer: The information provided is for educational and B2B formulation purposes. Final product claims must be validated by the brand owner according to local cosmetic regulations.

NanoActive DMC

Posted on 04/30/202604/30/2026 by L, Y

Advanced Delivery System by PuriPharm Co. Ltd.

Liposomal Dimethylmethoxy Chromanol. The ultimate dual-scavenger shield against Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), engineered for maximum bioavailability.

1. Redefining Antioxidant Protection

Dimethylmethoxy Chromanol is widely recognized as one of the most potent synthetic analogs of γ-tocopherol. Unlike traditional antioxidants that only target Oxygen free radicals, DMC is a unique dual-scavenger, effectively neutralizing both ROS and RNS, preventing lipid peroxidation and protein damage.

However, incorporating DMC into cosmetic formulations presents challenges due to its solubility and stability issues. PuriPharm’s NanoActive technology solves this by encapsulating DMC within nanometric liposomal vesicles. This structural mimicry of the stratum corneum ensures superior stability, profound epidermal penetration, and sustained release of the active molecule.

Key Advantages:

Dual Scavenging: Neutralizes both ROS and RNS, offering 360° cellular protection.
Liposomal Delivery: Nano-scale vesicles ensure deep penetration and prolonged efficacy.
Photo-aging Defense: Prevents UV-induced DNA damage and premature skin aging.
Formulation Friendly: Water-soluble liposomes easily integrate into aqueous phases.

2. The Science Behind the Shield

A targeted approach to cellular defense and delivery.

① ROS & RNS Quenching

Environmental stressors (pollution, UV) trigger ROS (like Superoxide) and RNS (like Peroxynitrite). DMC acts as an electron donor, rapidly stabilizing these radicals before they can initiate cascading lipid peroxidation in cell membranes.

② Phospholipid Bilayer Integration

PuriPharm encapsulates DMC in a flexible, biocompatible phospholipid bilayer. This liposome protects the fragile DMC molecule from premature oxidation within the cosmetic formula, dramatically increasing shelf-life.

③ Targeted Release

Due to their nanometric size (< 100nm) and biomimetic nature, the liposomes fuse with the stratum corneum, releasing DMC directly into the deeper epidermal layers where cellular protection is most critical.

3. Technical Specifications

Designed for cosmetic formulators seeking uncompromising quality, stability, and ease of use in advanced skincare architectures.

4. Applications

Anti-Aging Serums: Prevent structural protein degradation.
Anti-Pollution Creams: Shield against urban environmental stress.
Suncare & After-Sun: Mitigate UV-induced oxidative cascade.
Brightening Essences: Prevent oxidation-triggered melanogenesis.

LipoEcdysone™ PRO: The Biomimetic Phytosteroid Revolution

Posted on 04/24/202604/24/2026 by L, Y

Advanced Liposomal Hydroxyecdysone for High-Performance Cosmetics & Nutraceuticals

1. Product Concept: Unlocking Nature’s Blueprint

Hydroxyecdysone (20-HE) is a highly potent phytosteroid naturally found in select adaptogenic plants. Renowned for its extraordinary ability to stimulate cellular vitality and protein synthesis, its traditional application has been limited by poor solubility and low bioavailability.

Enter LipoEcdysone™ PRO. By utilizing cutting-edge, pharmaceutical-grade liposomal encapsulation technology, we have engineered a highly stable, bioavailable delivery system. Our biomimetic phospholipid vesicles seamlessly integrate with human cell membranes, ensuring deep tissue penetration and targeted active release—bridging the gap between natural potential and ultimate clinical efficacy.

2. The Liposomal Advantage: Science Meets Delivery

Standard Hydroxyecdysone struggles to cross the stratum corneum in skin or survive enzymatic degradation in the gut. Our proprietary liposomal matrix solves this:

Biomimetic Penetration: Phospholipid bilayers mimic cellular structures, facilitating endocytosis and direct intracellular delivery.
Enhanced Stability: Protects the active phytosteroid from oxidation, pH variations, and metabolic breakdown.
Sustained Release: Controlled time-release mechanism prevents active degradation and prolongs biological efficacy.

3. Cosmetic Applications (Personal Care)

Architecting Skin Density & Resilience from Within

In cosmetic formulations, LipoEcdysone™ PRO acts as a powerful anti-aging and skin-restoring agent. It stimulates the skin’s natural regenerative pathways without the side effects associated with synthetic retinoids.

Key Mechanisms & Benefits:

Epidermal Reinforcement: Accelerates keratinocyte differentiation, fortifying the skin barrier and increasing epidermal thickness.
Dermal Matrix Redensification: Up-regulates the synthesis of Collagen I and III, effectively improving skin elasticity and smoothing deep wrinkles.
Micro-Wound Healing: Ideal for post-procedure or compromised skin, promoting rapid tissue repair through enhanced cellular crosstalk.

Recommended Applications: Anti-aging serums, skin-barrier repair creams, post-treatment recovery lotions, and firming body care.

4. Nutraceutical Applications (Functional Foods & Supplements)

The Ultimate Natural Anabolic & Metabolic Adaptogen

For the sports nutrition and longevity markets, LipoEcdysone™ PRO delivers unparalleled systemic benefits. By significantly increasing oral bioavailability, lower dosages achieve superior physiological results.

Key Mechanisms & Benefits:

Muscle Protein Synthesis (MPS): Activates the PI3K/Akt signaling pathway, promoting lean muscle mass accretion and accelerating recovery post-exercise.
Metabolic Homeostasis: Acts as a powerful adaptogen, supporting glucose metabolism and mitigating the physical markers of stress.
Joint & Cartilage Support: Exhibits anti-inflammatory properties, preserving extracellular matrix integrity in joints for aging populations and athletes.

Recommended Applications: Sports recovery shots, longevity capsules, adaptogenic functional beverages, and joint-health gummies.

5. Technical Specifications & Formulation Guidelines

INCI Name: Phospholipids (and) PHYTOECDYSTEROIDS.
Appearance: Translucent to slightly opalescent fluid.
Particle Size (D50): < 150 nm (Ensuring optimal cellular uptake).
Solubility: Dispersible in water; compatible with both hydrophilic and lipophilic systems.
Recommended Use Level: * Cosmetics: 1.0% – 5.0% (Add during the cooling phase, below 40°C).

Nutraceuticals: Please refer to local regulatory guidelines for dietary supplement dosing.

Preservative System:Self-preserving / Preservative-free options available.
Sustainability: Ethically sourced botanical extracts, solvent-free liposomal extrusion process, 100% vegan and cruelty-free.

Disclaimer: The information provided is for B2B educational purposes. Finished product claims must be evaluated by the respective legal and regulatory bodies of the target markets.

NanoActive Sulfur PRODUCT DATA SHEET

Posted on 04/19/202604/19/2026 by L, Y

Advanced Nano-Encapsulated Bio-Derived Sulfur for Multi-Targeted Skin Solutions

Company: PuriPharm Co. Ltd.

Website: www.PuriActives.com

Contact: Service@puripharm.com | Tel: 13167223168

1. PRODUCT OVERVIEW

Sulfur is a naturally occurring nonmetal with a long-standing dermatological history of effectively treating various skin disorders. However, traditional sulfur applications are severely limited by poor water solubility, large particle sizes (2–5 μm), low bioavailability, and formulation challenges.

NanoActive Sulfur, developed by PuriPharm Co. Ltd., is a cutting-edge active ingredient that utilizes a proprietary Nano-Delivery System (NDS). By stably encapsulating highly active bio-derived sulfur into sub-30 nm lipid-based nanocarriers, it completely resolves traditional solubility and aesthetic issues. The result is a highly bioavailable, transparent, and universally compatible active that regulates sebum, reduces inflammation, and offers potent antibacterial properties for acne and scalp care.

2. COMPOSITION & INCI INFORMATION

NanoActive Sulfur is formulated using a specialized biomimetic lipid matrix designed for optimal trans-epidermal delivery. It is strictly free from added preservatives and antioxidants.

Composition Range Table:

3. TECHNICAL SPECIFICATIONS

4. TECHNOLOGY HIGHLIGHTS: THE NDS ADVANTAGE

Ultra-Fine Particle Size (< 30 nm): Significantly increases the specific surface area and interaction with keratinocytes, ensuring superior skin penetration and biological activity compared to traditional 2-5 μm sulfur.
Exceptional Formulation Flexibility: The unique hydrophilic-lipophilic structural modification allows NanoActive Sulfur to be seamlessly incorporated into lotions, creams, clear gels, and water-based formulas without precipitation.
Aesthetic Superiority: Unlike traditional sulfur, which is chalky and difficult to suspend, NanoActive Sulfur maintains optical clarity (forming a transparent solution at typical usage levels), leaving no residue and enabling elegant cosmetic formulations.
High Stability & Bioavailability: The robust phospholipid-based nanocarrier prevents aggregation, protects the active payload, and ensures targeted delivery to the sebaceous glands and follicles.

5. KEY COSMETIC BENEFITS & MECHANISM OF ACTION

A. Comprehensive Sebum Regulation & Keratolysis

Excessive sebum accumulation leads to enlarged pores, follicular blockage, and inflammation. NanoActive Sulfur effectively removes surface lipids, softens the epidermis, and dissolves keratin plugs.

●Mechanism:At low concentrations, sulfur exerts a keratoplastic effect, promoting normal keratinization. At higher concentrations, it becomes keratolytic, reacting with cysteine to form cystine and hydrogen sulfide (), which safely disrupts excess keratin and clears clogged pores.

B. Targeted Antibacterial & Antifungal Action

NanoActive Sulfur acts as a potent purifying agent and helps rebalance the skin microbiome.

●Mechanism: Skin bacteria and keratinocytes convert sulfur into pentathionic acid (), a compound highly toxic to fungi and pathogenic bacteria. The keratolytic action further helps detach microorganisms from the stratum corneum.

●Microbiological Efficacy (In Vitro):

○P. aeruginosa: MIC = 1.95 μg/mL | MBC = 1000 μg/mL

○S. aureus: MIC = 125 μg/mL

○E. coli: MIC = 500 μg/mL

C. Powerful Anti-Inflammatory & Soothing Properties

Severe oxidative stress depletes intracellular Glutathione (GSH), triggering inflammatory cascades.

●Mechanism:NanoActive Sulfur supports cellular antioxidant defenses by promoting GSH synthesis.

●Efficacy:Exerts a strong, dose-dependent reduction in the expression of key pro-inflammatory cytokines. Clinical evaluations (ELISA) show that concentrations between 0.1% and 0.4% significantly downregulate the protein expression ofIL-1β,IL-6, and TNF-α.

D. Clinically Proven Acne Treatment

Inin-vivoassessments, formulations containing NanoActive Sulfur demonstrated visible improvement in acne-prone skin profiles. A 60-day application of 0.2% active showed a significant reduction in inflammatory lesions and post-acne erythema, making it an ideal candidate for long-term acne management.

6. RECOMMENDED APPLICATIONS

NanoActive Sulfur is highly versatile and is recommended for the following cosmetic product categories:

Acne & Blemish Control: Spot treatments, anti-acne serums, and purifying toners.
Sebum Control & Pore Refining: Mattifying lotions, oil-control powders, and deep-cleansing masks.
Brightening & Spot-Fading: Post-inflammatory hyperpigmentation (PIH) correctors.
Scalp Care: Anti-dandruff shampoos and scalp-soothing serums (seborrheic dermatitis support).
Soothing & Repair: Products targeting sensitized, inflamed, or compromised skin barriers.

7. FORMULATION GUIDANCE

Suggested Use Level: 0.1% – 5.0% (Depending on target efficacy: low doses for daily maintenance/anti-inflammation; higher doses for targeted spot treatments).
Solubility: Amphiphilic nature allows it to be easily added to either the aqueous phase or the final emulsion at room temperature or gently heated conditions.
Compatibility: Compatible with a wide range of cosmetic ingredients, including traditional water-based and oil-based systems. Does not cause phase separation.

8. STORAGE, HANDLING & PACKAGING

Storage: Store in the original, unopened container at 4°C to 25°C. Protect from direct sunlight and maintain in a dry environment.
Shelf Life: 12 months under specified storage conditions.
Packaging: Supplied in standard industrial plastic containers.

Disclaimer: The information contained in this document is provided in good faith and is based on our current knowledge and internal testing. Formulators are responsible for ensuring the final cosmetic product’s stability, safety, and regulatory compliance in their respective target markets.

PuriPharm Co. Ltd. | Advanced Active Ingredients

NanoActive Sulfur

Posted on 04/18/202604/18/2026 by L, Y

Introduction

Sulfur is a yellow nonmetal widely distributed throughout the earth and has long been used as an effective treatment for various skin disorders. Its activity depends on the interaction between sulfur particles and keratinocytes: the smaller the particles, the larger the contact area and the better the efficacy. Bio-derived sulfur formed by the bacterial oxidation of sulfides into elemental sulfur shows better spreadability on the skin and higher activity.

NanoActive Sulfur, developed through a nano-delivery system, effectively regulates sebum secretion and helps treat acne and dandruff, while also providing strong antibacterial and anti-inflammatory activity.

Sebum Regulation

Excessive sebum secretion accumulates in follicles, enlarges pores, causes follicular blockage, and may even trigger inflammation.

NanoActive Sulfur effectively removes excess surface oil and helps soften the epidermis. It can also dissolve keratin and relieve skin imbalance caused by overactive oil secretion. In addition, it helps improve acne, pimples, and seborrheic dermatitis associated with overactive sebaceous glands.

Keratolytic Effect

Cystine is a major component of the stratum corneum. At low concentrations, sulfur promotes normal keratinization through its keratoplastic activity. At high concentrations, the same reaction produces a keratolytic effect because hydrogen sulfide disrupts keratin, and sufficient accumulation can dissolve the stratum corneum.

Therefore, NanoActive Sulfur is recommended for cosmetic formulations designed to regulate sebum secretion.

Antibacterial Action

The antibacterial action of sulfur depends on its conversion into pentathionic acid (H₂S₅O₆), a compound toxic to fungi. Hydrogen sulfide may also contribute to this activity. Through the action of skin bacteria and keratin-forming cells, sulfur can be converted into pentathionic acid. In addition, sulfur’s keratolytic activity may help separate fungi from the stratum corneum.

Therefore, NanoActive Sulfur is recommended for cosmetic formulations with purifying and preservative functions.

Pentathionic Acid Activity

Anti-inflammatory Action

Glutathione (GSH) is the most important cellular antioxidant. It exists in the reduced thiol form (GSH) and the oxidized disulfide form (GSSG), and undergoes thiol-disulfide exchange catalyzed by thiol transferases. Severe oxidative stress depletes intracellular GSH.

NanoActive Sulfur can promote GSH synthesis while reducing pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α, delivering a strong anti-inflammatory effect.

Inflammatory Factor Reduction

The protein expression levels of TNF-α, IL-1β, and IL-6 were measured by ELISA.

Compared with the control group, NanoActive Sulfur reduced the expression of TNF-α, IL-1β, and IL-6 in a dose-dependent manner.

NanoActive Sulfur in Acne Treatment

5% NanoActive Sulfur 2 months

Visible improvement in acne appearance after continuous use.

Challenges in Sulfur Applications

Advantages of NanoActive Sulfur

NanoActive Sulfur has a unique chemical structure (linear and hydrophilic), making it easier to formulate, easier to combine with other ingredients, and easier to absorb.

Nano-delivery System

NanoActive Sulfur developed with a nano-delivery system (NDS) has a particle size below 30 nm. It completely solves sulfur solubility issues by stably encapsulating sulfur inside nano-carriers, greatly improving absorption efficiency and bioavailability.