Nano Liposomal Vitamin E (NanoActive E)

NanoActive E is a new type of vitamin E nanoliposome preparation (NanoLiposomal E).
Product Name: Nano Liposomal Vitamin E; Nanoactive Vitamin E; BioaActive Vitamin E; BioActive E; Nano Active E; Soluble Vitamin E CAS: 10191-41-0, 7695-91-2, 59-02-9

Description: Vitamin E is a fat-soluble vitamin, widely found in leaves, cereal oil and milk. It is a famous antioxidant and moisturizing ingredient and one of the essential components in the epidermis. Vitamin E can reduce the aging of tissue cells and the production of streak tissue, improve the effect of vitamin A, and prevent the oxidation of vitamin A and vitamin C. The external use of vitamin E has been proven to be effective in supplying vitamin E to the skin. However, pure vitamin E in cosmetic formulations is easily to be oxidized and is only oil soluble. Vitamin E wrapped in NanoActive is highly stable and soluble in water.

Features

  • NanoActive E is 100% water soluble and 100% oil soluble (amphiphilic) for a wide range of application.
  • NanoActive E greatly improves the stability and bioavailability of vitamin E
  • NanoActive E has good heat, pH and shear stability and is easy to use
  • NanoActive E is rich in active substance, which can be up to 20%
  • NanoActive E uses FDA GRAS grade materials for high safety
  • NanoActive E can increase the amount of vitamin E infiltrated into the depth of the epidermis while traditional oil-in-water emulsion loose vitamin E can only stay on the skin surface.

Efficacy:

  • NanoActive E effectively neutralizes free radicals, improves skin texture and reduces the appearance of wrinkles
  • NanoActive E can improve the stability of other active substances such as vitamin C in the product and promote the absorption of active substances by the skin.

Scope of application:

Eye care products, anti-aging products such as serum, eye mask, facial mask, skin care, etc.

Use: Add it at room temperature. You may heat it to above 40℃ to speed up the dissolution. Recommended dosage: 1-5%. Better effect with products containing NanoActive Q10.

Storage: Recommended to store it at 2-8°C

Packing specifications: 1kg, 5kg, 10kg

Recommended dosage: 0.5-5.0%

NanoActive C

Nanoactive C is a novel vitamin C nanoliposome formulation (NanoLiposomal C).
Product Name: Nano Liposomal Vitamin C; Nanoactive Vitamin C; BioaActive Vitamin C; BioActive VC; NanoActive VC; Oil Soluble Vitamin C; Fat Oil Soluble Vitamin C; Water Soluble Vitamin C; CAS: 50-81-7

Description: Vitamin C (Ascorbic Acid), also known as L-ascorbic acid, is a water-soluble vitamin.” Vitamin C is an important antioxidant, involved in multiple reactions in vivo which has functions such as promoting collagen production, blocking melanin synthesis, scavenging free radicals, and preventing skin aging. It is one of the most classic and active actives in cosmetics. Vitamin C is insoluble in fat-soluble systems and extremely unstable in aqueous solution, which limits its use greatly. Although a variety of vitamin C derivatives have been developed and used, they must be converted into a prototype vitamin C into the body to function, and their activity is greatly reduced. L-Vitamin C (“Left C”) is the only form of vitamin C that can be directly absorbed by human skin. NanoActive C is a L-Vitamin C nano-active material developed by Nano Transmission System (NDS) and with an average particle size of less than 30 nm. It also solves the problem of solubility and stability of vitamin C, allowing vitamin C to be stably encapsulated in nano-carriers. It can greatly increase the absorption rate and bioavailability, and greatly expand its application range.

Vitamin C

 


Vitamin C physiological activity

  • Ascorbic activity (promotes collagen synthesis)
  • Resistance to oxidation
  • Inhibition to melanin synthesis
  • Improvement in immune system

 

Features

  • NanoActive C is a non-chemically modified stable L-C nano product that works directly and efficiently without the need of vivo transformation.
  • NanoActive C uses GRAS (Recognized Safety) grade materials for high safety and non-irritation
  • NanoActive C is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.
  • NanoActive C greatly improves the stability and bioavailability of vitamin C
  • NanoActive C is stable to heat, pH and shearing, so it is convenient to use.

Distribution map of NanoActive C particle size

Efficacy:

  • NanoActive C inhibits melanin formation and reduces melanin by inhibiting tyrosinase activity. It also diminishes formed spots, eliminates pigmentation, and reduces sunburn and freckles caused by sunlight.
  • It protects the skin from lesions caused by UV rays, such as the skin lines acquired.
  • L-Vitamin C is an essential ingredient in the manufacture of collagen, and collagen is the main component of the dermis. NanoActive C promotes collagen synthesis to reduce fine lines.
  • NanoActive C can effectively neutralize free radicals, promote skin metabolism, accelerate skin rejuvenation, improve skin texture, restore damaged skin, and make skin firm and elastic
  • NanoActive C can improve the stability of other active matters in the product and facilitate absorption

Melanocytes

 

Whitening mechanism of NanoActive C

Vitamin C inhibits UV-induced skin damage

 

 

 

 

 

 

 

Vitamin C inhibits melanin production in B16 melanocytes

 

 

 

 

 

 

 

Vitamin C promotes collagen synthesis in human fibroblasts

 

Potential use of NanoActive

  1. Maintanance of skin elasticity

– Enhance collagen synthesis

  1. Whitening effect

– Antioxidant (reduction)

– Inhibition to tyrosinase activity

  1. Prevent skin inflammation and photoaging

– Antioxidant (eliminating hydroxyl radicals)

Use:add it at ordinary temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%. Better effect with products containing vitamin E and ferulic acid.

Storage: keep it away from light at a temperature below 25℃.

 

NanoActive THC

NanoActive THC is a novel tetrahydrocurcumin nanoliposome preparation (NanoLiposomal THC).
Product Name: Nano Liposomal THC; Nanoactive THC; BioaActive THC; BioActive Tetrahydrocurcuminoids; NanoActive Tetrahydrocurcuminoids; Water Soluble Tetrahydrocurcuminoids; Fat Soluble Tetrahydrocurcuminoids

CAS: 36062-04-1

Description:Tetrahydrocurcumin (ultra pure whitening element) is a natural functional whitening ingredient extracted from the roots of Ginger Curcuma longa.Thanks to its potent activity against tyrosinase, the whitening effect of this product is better than that of arbutin; it can effectively inhibit the formation of oxygen free radicals as well as eliminate the formed free radicals. Featured with significant antioxidant effects, such as anti-aging of human skin, skin repair, lightening pigments, clearing freckles, etc., it is widely applied in various skincare products for whitening, freckle eliminating, and anti-oxidation. Tetrahydrocurcumin is hardly soluble in water while easy to be oxidized and discolored, which limits its application in cosmetics. Nano actives with a particle size of less than 30 nm developed by nano-transmission system (NDS) enable tetrahydrocurcumin to be steadily wrapped in nano-carriers, greatly improving the absorption efficiency and bioavailability. This overcomes the original defects and maintain the advantages with a more convenient and wider range of uses.

Tetrahydrocurcumin

Skincare Effect

Tetrahydrocurcumin (ultra pure whitening element) is a perfect comprehensive natural ingredient for whitening and a high-purity turmeric extract that can inhibit tyrosinase at a extremely low concentration. Its whitening effect is several times that of common whitening active ingredients such as arbutin, licorice and vitamin C. It also has a unique bio-protective function, which can provide skin with double anti-oxidation protection, helping the skin to resist the damage of UV rays and inflammation. Safety tests show that it has no side effects of any irritation or sensitization on human skin, and can safely and effectively perform the function of natural whitening and skin brightening. Compared with the western medicine phenylbutazone, ultra-pure whitening element can achieve the same effect with half of its dose. Compared with curcumin and its analogues, ultra-pure whitening element is more effective for acute and subacute inflammation. The inhibition of ultra-pure whitening element against lipoxygenase, collagenase and hyaluronidase reduces the formation of skin inflammation including erythema, while also reducing wrinkles, maintaining skin elasticity and anti-aging.While whitening the skin, it can also improve the skin texture, increase the gloss, and make the skin look healthy and bright. Therefore, ultra-pure whitening element is a comprehensive natural extract for whitening. It is a natural whitening material with comprehensive functions such as resisting UV, anti-oxidation, inhibiting inflammation and tyrosinase, lightening melanin, etc. In comparison with similar products in the market, its whitening effect of lightening melanin is excellent, and it also has many other skin bioprotective effects, which is an advantage that other raw materials cannot match. Widely applied, it is a whitening additive recognized by famous cosmetics companies around the world.

 

 

 

 

Tetrahydrocurcumin can effectively eliminate oxygen free radical

Tetrahydrocurcumin has significant anti-inflammatory effects

Experiments showed tetrahydrocurcumin’s excellent whitening effect

 

Features

  • NanoActive THC solves the problem of tetrahydrocurcumin’s tendency to be oxidized and discolored.
  • NanoActive THC uses FDA GRAS materials for high safety.
  • NanoActive THC has a good stability towards heat, pH and shearing and is easy to use.
  • NanoActive THC greatly improves the stability and bioavailability of tetrahydrocurcumin.
  • NanoActive THC improves the stability of other actives in the product and promotes absorption.
  • NanoActive THC is 100% water soluble and 100% oil soluble (amphiphilic), allowing a wide range of uses.

 

Applications

  • Inhibit melanin synthesis, reduce pigmentation and whiten your skin
  • Eliminate free radicals and confront skin aging
  • Promote collagen synthesis, improve skin thickness and elasticity, remove wrinkles, and firm your skin
  • Help wound healing and reduce scars
  • Anti-glycosylation
  • Cure acne and reduce acne marks.
  • Anti-bacteria, diminish inflammation and sensitization, and provide analgesic effects
  • Prevent scarring and fibrosis

  Use: Add it at room temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%. The optimum pH range of the system is 3.0-6.5, and the finished product should be protected from direct exposure to sunlight (using opaque packaging). It is recommended that UV absorber be added to day care products.

Storage : keep it away from light at a temperature below 25℃.

 

NanoActive SA

Nanoactive SA is a novel salicylic acid nanoliposome preparation (NanoLiposomal SA).
Product Name: Nano Liposomal SA; Nanoactive SA; Nano Active Salicylic Acid; Water Soluble Salicylic Acid; Fat Soluble Salicylic Acid; BioActive Salicylic Acid CAS: 69-72-7

Description: Salicylic acid is Beta Hydroxy Acid, also known as BHA or B softening fruit acid, which is found in willow barks, wintergreen leaves and sweet birches in nature. Salicylic acid has an excellent ability to clear acne, exfoliate, and clean pores with high safety. Salicylic acid can also lighten pigment spots, shrink pores, remove fine wrinkles and improve aging caused by sun exposure, thus becoming the new favor of skincare products. However, salicylic acid is hardly soluble in water and is highly irritating, which limits its application. The Nano SA actives, developed with the nano-transmission system (NDS), has a particle size of less than 30nm, which enables salicylic acid to be steadily encapsulated in nano-carriers, greatly improves the absorption efficiency and bio-availability. This overcomes the original defects and maintain the advantages with a more convenient and wider range of uses.


White willow                                                      Salicylic acid

 

Features:

  • NanoActive SA uses FDA GRAS grade materials for high safety
  • NanoActive SA is stable to heat, pH and shearing, so it is convenient to use.
  • NanoActive SA overcomes the original shortcomings of salicylic acid while maintaining the advantages, and improves bioavailability
  • NanoActive SA can improve the stability of other active matters in the product and facilitate absorption

 

Efficacy:

  • It increases the absorption of your skin. When combined with other skincare ingredients, salicylic acid increases the absorption of actives by the skin.
  • It clears pore blockage. This gentle acid can decomposes blackheads and whiteheads by strip the outer layers of your skin.
  • Exfoliate and cleanse. Salicylic acid is a keratolytic agent that not only has exfoliating effect, but also has anti-bacterial effect. At the same time, it can remove dead cells from the skin and prevent the acne caused after the mix between dirt and sebum.
  • It resists dryness. Salicylic acid softens keratin and helps protect skin from dryness.

 

Use: Add it at room temperature. You may heat it to over 40℃ to speed up the dissolution. Recommended dosage: 1-5%. Divalent or trivalent metal ions such as iron must be avoided in the system.

 

Storage: Keep it away from light at a temperature below 25℃.

 

 

 

 

 

 

NanoActive RAL

Nanoactive RAL, INCI name: Retinal, CAS: 116-31-4.

Product Name: Nanoactive RAL, BioaActive Retinaldehyde; BioActive Retinal; Soluble Retinal; Soluble Retinaldehyde;Nano Liposomal

Nanoactive RAL is a novel retinal nanoliposome formulation (NanoLiposomal RAL).

A new liposome preparation. RAL has the characteristics of retinoic acid in the skin, and is better tolerated than retinoic acid. It directly interacts with protein receptors in cells, stimulates epidermis to accelerate regeneration, increases the thickness of the stratum corneum, and makes the skin tighter and more orderly. It also accelerates the production of collagen in the dermis layer, prevents the damage of UV to collagen, inhibits the increase of MMP caused by UV, and makes the skin more elastic; the unique aldehyde-based structure has a very good effect on P. acnes, etc., and effectively improves acne skin. Large amounts of retinal, retinol, retinol retinate (15498-86-9), HPR(893412-73-2) and other Vitamin A kind products of pharmaceutical grade are available.

 

Description:

Retinaldehyde (RAL), also known as vitamin A aldehyde, is a derivative of retinol after oxidation. It is formed by oxidative cleavage of β-carotene. If  reduced, retinol can be attained; If oxidized, retinoic acid can be attained.Retinoic acid。”. The role of retinoic acid (Vitamin A) in skin diseaseis very extensive, but due to local irritation, its clinical application is limited to some extent.Retinaldehyde is an intermediate metabolite of natural retinoic acid and has similar biological activity as retinoic acid. But the skin is significantly more tolerant to retinoic acid.

The main forms of vitamin A and their interconversion

Retinal has many target on the skin. It can be used as a skin care product to produce a variety of effects such as anti-aging, skin rejuvenation, whitening, anti-wrinkle, acne, keratin, etc. It is an emerging high-efficiency natural active substance. Retinal is hardly soluble in water while easy to be oxidized and discolored, which limits its application in cosmetics. Nano actives with a particle size of less than 30 nm developed by nano-transmission system (NDS) enable retinals to be steadily wrapped in nano-carriers, greatly improving the absorption efficiency and bioavailability. This overcomes the original defects and maintain the advantages and enables a more convenient and wider range of uses.

Skin care effect

The large use of non-physiological doses of exogenous retinoic acid can cause an overload of the retinoic acid-dependent pathway in the skin, causing adverse reactions such as skin irritation. RAL is a natural metabolite of retinol and a direct precursor of retinoic acid, and it also has similar biological activity to retinoic acid. The advantage of RAL compared with retinoic acid is its multi-directional metabolism, that is, the excess RAL can be rapidly reduced to retinol, then stored and inactivated in the form of retinol, and this “reverse metabolism” is not present in retinoic acid. After it is absorbed by the skin, most of it is converted to retinol vinegar stored for slow release, and a small amount of RAL is oxidized to retinoic acid by keratinocytes in differentiation-dependent manner, while a very small amount of retinoic acid is can exert significant biological effects in cells. This can avoid skin adverse reactions caused by high doses of retinoic acid. Clinical observations also show that topical RAL creams are well tolerated compared with retinoic acid and can be applied to sensitive areas. The topical RAL cannot absorbed by human blood. The levels of various vitamin A acids in the blood also cannot be affected.

RAL needs to be activated by the conversion of enzymes in keratinocytes to retinoic acid, so RAL has similar biological activity as retinoic acid. One of the indicators of retinoic acid activity is to induce the expression of retinoic acid binding protein (CRABP-2) in cells. External RAL can evidently induce the expression of CRABP-2 mRNA and protein. The topical natural retinoic acidcan also induce the expression of nuclear receptor in retinoic acid . Like retinoic acid, RAL also functions to regulate cell proliferation and differentiation. It can increase epidermal DNA synthesis, increase epidermis thickness, induce 50kD keratin, and reduce 7OkD keratin mRNA expression. Inducing positive keratinization, reducing 65kD keratin mRNA expression, and increasing filaggrin and loricin mRNA expression. In addition, RAL is also involved in the regulation of neovascularization in the skin, inhibiting the production of vascular endothelial growth factor by keratinocytes. It can repair the elastic fibers and collagen damage induced by UVA. RAL is also capable of dissolving acne and the direct sterilizing effect towards propionibacterium acnes. Natural retinoic acid play an important role in epidermal differentiation, dermal remodeling and curing skin inflammation. Retinaldehyde as an important intermediate metabolite of natural retinoic acid has both biological activity similar to that of retinoic acid and is well tolerated by the skin, thus it is given wider application in cosmetics.

Retinaldehyde can repair elastic fiber and collagen loss caused by UV:

Retinaldehyde prevents skin aging caused by ultrasound and fluid

technology:

 

Retinaldehyde can effectively improve skin photoaging symptoms:

 

 

Retinaldehyde and retinal are well tolerated, while retinoic acid is more irritating

Retinaldehyde can effectively inhibit epidermal melanin

Features

  • NanoActive Retinaldehyde uses FDA GRAS grade materials for high safety
  • NanoActive Retinaldehyde has good heat, pH and sheer stability and is easy to use.
  • NanoActive Retinaldehydegreatly enhances the stability and bioavailability of retinal
  • NanoActive Retinaldehyde can improve the stability of other active matters in the product and facilitate absorption
  • NanoActive Retinaldehyde is 100% water soluble and 100% oil soluble, allowing a wide range of uses.

 

Applications

  • Wrinkle repairing: promote collagen and hyaluronic acid synthesis, increase skin thickness and elasticity, repair the wrinkle and firm the skin.
  • Whitening and freckle removing: inhibit melanin synthesis, reduce pigmentation, whiten the skin and remove the freckle.
  • Anti-aging: anti-oxidation, anti-skin-aging
  • Skin-refreshing: renewal of keratin, refresh the skin.
  • Acne Treatment: sterilizing propionibacterium acnes and streptococcus, etc., treating acne and removing acne marks
  • Curing of skin photoaging

 

 Use: Add it at room temperature; recommended dosage: 1-5% The optimum pH range of the system is 3.0-6.5, and the finished product should avoid direct exposure to sunlight (using opaque packaging). It is recommended to add UV absorber to day care products.

 

Storage: keep it away from light at a temperature below 25℃.

 

NanoActive Sulfur

Nanoactive Sulphur is a new type of sulphur nanoliposome preparation (NanoLiposomal Sulphur).
Product Name: Nano Liposomal Sulfur; Nanoactive Sulfur; BioaActive Sulfur; Soluble Sulfur CAS: 7704-34-9

Description

Sulfur has long been an effective drug for the treatment of various skin diseases. It is a yellow non-metallic element widely distributed in the earth’s crust. The function of sulphur depends on its direct interaction with the skin. The smaller the particles are, the larger the effective area of ​​interaction between sulfur and the skin is, and the greater the efficacy is. Nanobiosulfuris a sebum regulating agent that has triple effects on problem skin, namely antibacterial, anti-inflammatory and sebum regulating. Water-soluble and non-irritating to the skin, in cosmetics, it can regulate the secretion function of sebaceous glands, facilitate skin whitening. It is also effective in anti-bacteria, reducing the appearance of whelk, acne and dandruff. SulfurSarcoptic Mitecan kill bacteria and fungus, strip the skin of oil, soften the epidermis, dissolve the keratin Sulfurby forming pentathionic acidSecretionafter interactingHydrogen sulfidewith skin and tissue.

Lipoic acid nanoactive material with a particle size of less than 30 nm developed by Nano-transport system (NDS) has completely solved sulfur’s solubility problem, allowing it to be stably encapsulated in a nanocarrier, which can greatly increase its absorption efficiency and bioavailability.

Lipoic acid’s structure

 

 

Sulphur is a yellow colored non-metal element, widely distributed throughout the planet. Different sulphur-based topical preparations have been developed through the years.

Sublimed sulphur is prepared by changing sulphur from solid to gas (sublimation). The resulting gas is subsequently condensed into fine yellow powder, which can be used in different ways. The physical properties of sublimed sulphur differ from those of precipitated sulphur. Sublimed sulphur, Washed sulphur, is made of large particles with mild therapeutic efficacy; it is yellow, nonsoluble in water or alcohol, slightly soluble in olive oil (10%) and tastes slightly acidic. Washed sulphur is sublimed sulphur, treated With diluted ammoniac first and boiling water afterwards. Precipitated sulphur, also called magistery of sulphur or milk of sulphur, is made of small particles with high therapeutic efficacy; it is whitish-yellow, non soluble in water, slightly soluble in alcohol, soluble in 1:100 olive oil and insipid.

Nanoactive sulphur consists of minute particles, smaller than those of precipitated sulphur (1 to 100 nm), which can be suspended in a colloidal solution. So far, this form is considered the most active one. Currently, the so-called biosulphur is most Frequent used, because of its better diffusion and higher activity on the skin.

 

TRADITIONAL USES

Sulphur has been used for medicinal purposes since the times of Hippocrates. Commercially, this product is important to produce sulphuric acid, abundantly used in the chemical industry and others.

 

COSMETIC PROPERTIES

Keratolytic properties

The action of sulphur depends on its direct interaction with the skin. The smallest particle sizes have the largest interaction area and therefore, they are most efficient. For many years, sulphur has been considered a specific remedy for seborrhea, used as octahedral sulphur solution in The therapeutic effects of sulphur on acne-prone skin or skin with excessive sebum secretion could result from its keratolytic action. The mechanism underlying such effect is not known; it probably depends on the interaction of sulphur with the cysteine Into keratinocytes

 

 

Cystine is a major constituent of the horny layer. This reaction promotes normal keratinization, due to the keratoplastic effect of sulphur, applied at low concentrations.Applied at high concentrations, the same reaction causes keratolytic effects, because sulphur hydrogen breaks keratin.It is possible That applications of high sulphur concentrations on the skin result in sulphur hydrogen enough enough to dissolve the horny layer

Therefore, nanoactive sulphur fluid is recommended to formulate cosmetic products with regulatory activity on sebum secretions.

 

Antifungal action

Sulphur antifungal action depends on the conversion of sulphur into pentathionic acid, a

Compound toxic to fungi. Sulphur hydrogen formation could also be involved in this action.

Applied on the skin, sulphur turns into pentathionic acid due to the action of skin bacteria and

Keratinolytic. of keratolytic action of sulphur could cause the fungi to detach from the horny layer

Therefore, nanoacive sulphur fluid is recommended to formulate cosmetic products with purifying and antiseptic action

COSMETIC APPLICATIONS

 

Features

  • NanoActive Sulfur uses FDA GRAS grade materials for high safety
  • NanoActive Sulfur has good heat, pH and shear stability and is easy to use.
  • NanoActive Sulfur greatly improves the stability and bioavailability of ALA
  • NanoActive Sulfur improves the stability and absorption of other actives in the product
  • NanoActive Sulfur is 100% water soluble and 100% oil soluble (amphiphilic) for a wide range of applications

 

Product use:Add at room temperature,heat it to above 40°C to speed up its dissolution. Recommended dosage: 1-3%. Better effect with products containing lipoic acid.

Product storage: Keep below 25°C and away from light.

 

 

NanoActive Repair

Nanoactive Repair is a novel ceramide nanoliposome preparation (NanoLiposomal Repair).
Product Name: Nano Liposomal Ceramide; Nanoactive Ceramide; BioaActive Ceramide; Soluble Ceramide; Nanoactive Repair; Bioa Active Repair; SymRepair 100 CAS: 100403-19-8

Description: The results of skin research indicate thatceramide is the main component of the skin’s stratum corneum lipids, accounting for about 50% of the epidermal keratinous lipid content. It plays a key role in the physiological function of the stratum corneum and takes on the role of skin protection, moisturizing and nourishing. The application of a skincare product containing ceramide for external use can achieve the purpose of preventing allergic skin diseases and the effect of suppressing melanin brown spots. The ceramide-3 with the same structure as natural ceramide is used as the raw material. The nano-ceramides, developed with the nano-transmission system (NDS), has a particle size of less than 30nm, which solves the problems of solubility and irritation, so that it is stably encapsulated in nano-carriers to synergize with natural stratum corneum components of skin, such as phospholipids, cholesterol and stearic acid to repair the barrier.

Ceramide-3 structure

 

The main role of ceramide in the stratum corneum of the epidermis:

  • Barrier: As long as the ceramide is removed from the epidermis, the barrier function of the skin disappears.
  • Adhesion: Ceramide can significantly enhance the adhesion between keratinocytes, improve skin dryness and reduce skin desquamation.
  • Moisturizing: Ceramide has a strong ability to associate water molecules, maintaining the moisture of the skin by forming a network in the stratum corneum.
  • Anti-aging: Ceramide can improve skin dryness, desquamation, roughness and tarnishing, increase skin thickness, improve skin moisturizing ability, reduce wrinkles, increase skin elasticity and delay skin aging.
  • Anti-allergy: Ceramide can help the stratum corneum thicken significantly, improve the skin’s tolerance, inhibit the invasion of harmful substances from the outside, avoid the sensitivity of skin caused by the invasion, and have the effect of restoring couperose skin.

However, many skin conditions can cause a decrease in ceramide levels leading to impaired skin barrier (more than 50% reduction in total ceramide or single ceramide):

  • Aging
  • Allergic dermatitis
  • Dry skin / dry skin in winter
  • Dandruff
  • Psychological stress
  • Gender (older women versus older men)
  • Race/skin type

Ceramide is the most important component of the lipid barrier of the skin, and ceramide can repair the skin barrier function. However, it is difficult to extract natural ceramides, to synthesize natural ceramides, to formulate natural or natural ceramides with high melting point (over 90 C), and to crystallize low concentration, ineffective and high concentration products, which limit the use of ceramides. A new type of synthetic ceramide developed similar to the natural ceramide structure is used as the raw material, and the nano-ceramides with a particle size of less than 30 nm developed by the nano-transport system (NDS) have solved the problem of solubility and applicability. It is stably encapsulated in a nanocarrier to synergize with skin natural stratum corneum components such as phospholipids, cholesterol and stearic acid to repair the barrier.

Research shows this product has:

  • A dose-dependent feature in repairing skin lesions
  • A comparable efficacy to natural ceramide
  • An effect of preventing skin lesions
  • A restoring effect
  • A good moisturizing effect

Ceramide for allergic skin repair

Ceramide can effectively reduce the water flux of defatted pigskin (in vitro)

 

Ceramide effectively reduces the transepidermal water loss rate of human bodies (TEWL)

Applications:

  • Skincare
  • Bodycare
  • Facial care
  • Dry skin care
  • Winter skincare
  • Daily skincare
  • Anti-aging products
  • Products for sensitive skin
  • Sunscreen products
  • After-sun repair products

 

Use:Add it at an ordinary temperature; recommended dosage: 5-10%. Better effect with products such as yeast glucan liposome.

Storage: Keep it away from light at a temperature below 25℃.

 

Nano-Lipoic Acid (NanoActive ALA)

Nanoactive ALA is a new type of lipoic acid nanoliposome preparation (NanoLiposomal ALA).
Product Name: Nano Liposomal ALA; Nanoactive ALA; BioaActive ALA; BioActive Alpha lipoic acid; NanoActive Alpha lipoic acid; Soluble alpha lipoic acid; Soluble ALA CAS: 62-46-4

Description: Alpha lipoic acid is an enzyme existing in mitochondria, which is similar to vitamins and can  eliminate free radicals that accelerate aging and cause disease. Lipoic acid has both fat-soluble and water-soluble properties, so it can pass through the entire body and reach every cell, providing comprehensive performance for human body. It is an all-purpose antioxidant with fat solubility and water solubility. Lipoic acid has the antioxidant effects 400 times greater than that of vitamins C and E, and it can greatly enhance the effects of vitamins C and E. Also, its efficacy lasts longer than other antioxidants. Smaller than the molecules of vitamin E, it can be easily absorbed by the skin and be effective in beautifying, activating cells and facilitating hair growth. Lipoic acid is effective in removing dark eye circles, wrinkles and spots. In addition, it enhances metabolism, improving the body’s blood circulation, so that skill will no longer be dull and the appearance or pores will be minimized, making your skin enviously firm and delicate. Therefore, lipoic acid is also an anti-aging nutrient that ranks the first place in the United States, which ties with ALA. The lipoic acid nanoactive material with particle size less than 30nm developed by nano-transmission system (NDS) completely solves the problem of solubility, and allows lipoic acid to be stably encapsulated in nano-carriers, which can greatly increase its absorption efficiency and bioavailability.

Lipoic acid’s structure

 

 

Lipoic acid is an powerful versatile anti-oxidant that can regenerates other antioxidants.

 

Lipoic acid (LA) target against skin aging

Features

  • NanoActive ALA uses FDA GRAS grade materials for high safety.
  • NanoActive ALA has good heat, pH and shear stability and is easy to use
  • NanoActive ALA greatly improves ALA’s stability and bioavailability
  • NanoActive ALA improves the stability and absorption of other actives in the product.
  • NanoActive ALA is 100% water soluble and 100% oil soluble (amphiphilic) for a wide range of applications.

 

Efficacy

  • NanoActive ALA can enhance the anti-oxidation effect of skin cells, reduce the damage from free radicals to the skin, significantly reduce skin roughness, eliminate freckles and reduce the appearance of fine lines.
  • NanoActive ALA is an active functional ingredient that is effective in anti-wrinkles, whitening, anti-aging, moisturizing and increasing skin elasticity.
  • It helps to enhance the efficacy of antioxidants such as polyphenols and kinetin, and also reduces the endogenous antioxidants.

   Use: Add it at room temperature. You may heat it to above 40 °C to speed up its dissolution, Recommended dosage: 1-3%. Better effect with products containing lipoic acid.

Storage: Keep it away from light at a temperature below 25°C.

 

 

Experimental proof

Effect of lipoic acid on cell activity

Lipoic acid’s whitening effect

Lipoic acid’s anti-wrinkle effect