Tag Archives: anti-free radicals

NANOACTIVE ENOXOLONE PuriActives Core Molecule x NanoActive Delivery

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PuriPharm: Dual Pillars of Innovation

Two Core Innovation Pillars

PuriActives: Enoxolone from Licorice Root

NanoActive NanoCarrier: Delivery Architecture

Application Challenges: Enoxolone Limitations

NanoActive System Solution

NanoActive Enoxolone = PuriActives Molecule + NanoActive Technology

Through nano-encapsulation, insoluble crystalline powder becomes a clear, transparent, stable bioactive liquid. We deliver precision-calculated efficacy.

NanoActive Parameters: Size Advantage

Product Technical Specifications

NanoActive Drives Deep Penetration

Multi-dimensional Efficacy

Anti-inflammatory Power: TSLP Inhibition

Clinical Evidence: Atopic Dermatitis Relief

NanoActive Antioxidant Defense Matrix

11β-HSD1 Inhibition: Correcting Steroid Skin

Antimicrobial Activity

Skin Barrier Repair & Soothing

Formulation Application Guide

NanoActive Phloretin

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Advanced Nano-Delivery System for Enhanced Bioavailability & Skin Penetration

1.PRODUCT DESCRIPTION

NanoActive Phloretin is a highly advanced, water-dispersible nano-structured delivery system developed specifically for high-end cosmetic and dermatological formulations. Phloretin, a natural dihydrochalcone polyphenol primarily extracted from the root bark of apple trees (Malus domestica), possesses extraordinary biological properties including potent tyrosinase inhibition, broad-spectrum free radical scavenging, anti-inflammatory effects, and cellular DNA protection.

Despite its remarkable therapeutic potential, raw crystalline Phloretin faces significant formulation constraints in personal care applications due to its severe lipophilicity, poor aqueous solubility, susceptibility to oxidation, and limited capacity to cross the thermodynamic barrier of the stratum corneum. PuriPharm overcomes these challenges by utilizing an innovative multi-lamellar liposomal architecture. By encapsulating Phloretin into nanostructured lipid matrices (Particle Size < 50 nm), the system dramatically amplifies active molecule stability, optimizes delivery kinetics, and increases biological skin absorption without the use of irritating organic solvents or high alcohol levels.

2.TECHNICAL SPECIFICATIONS

3. BIOLOGICAL EFFICACY & MECHANISMS

3.1 Advanced Melanin Regulation & Skin Whitening

NanoActive Phloretin acts as a highly effective inhibitor of mammalian tyrosinase, the rate-limiting enzyme in melanogenesis. It downregulates the conversion of L-tyrosine to L-DOPA, suppressing melanin synthesis at a cellular level. Clinical data exhibits an ultra-low half-maximal inhibitory concentration (IC50 = 37.5 μmol/L), significantly outperforming traditional agents like Kojic Acid and Arbutin. The nano-delivery system ensures active transport into basal layer melanocytes, effectively fading post-inflammatory hyperpigmentation (PIH), evening out skin tone, and enhancing overall skin translucency and L* luminosity values.

3.2 Comprehensive Antioxidant & Radical Scavenging Architecture

The polyphenolic structure of Phloretin offers powerful electron-donating properties to neutralize destructive reactive oxygen species (ROS). In comparative DPPH radical scavenging assays executed within aqueous environments, standard crystalline Phloretin displays suboptimal performance due to poor phase dispersion. Under identical aqueous test conditions:

Pure Crystalline Phloretin: 42% free radical scavenging capacity.

L-Ascorbic Acid (Vitamin C): 88% free radical scavenging capacity.

NanoActive Phloretin: 94% radical scavenging efficiency.

This distinct upregulation is driven by the amphiphilic lipid membrane shell, which maximizes contact surface area with free radicals in the water phase while preserving the inner molecular integrity of the active polyphenol.

3.3 Sebum Regulation & Anti-Acne Efficacy

NanoActive Phloretin modifies the sebaceous microenvironment through multi-pathway mechanisms. It restricts excessive sebocyte lipogenesis, yielding a quantifiable reductions in sebum output and a long-lasting matte skin finish within 4 weeks. Concurrently, its strong anti-inflammatory properties inhibit Prostaglandin E2 (PGE2) secretion and cyclooxygenase-2 (COX-2) expression, yielding a 29.1% reduction in inflammatory pustules and acne-induced erythema.

3.4 Deep Cellular DNA Shield & Photo-Aging Defense

Beyond traditional cosmetic benefits, NanoActive Phloretin provides genuine biological protection against ultraviolet (UV) irradiation. It enters viable epidermal layers to prevent the formation of cyclobutane pyrimidine dimers (Thymine Dimers) within cellular DNA. It dampens ultraviolet-induced p53 protein expression (a critical cellular stress indicator) and strictly blocks the up-regulation of Matrix Metalloproteinase-9 (MMP-9), thus preventing the structural breakdown of dermal collagen matrices and mitigating chronic photo-induced aging.

4. FORMULATION & PROCESSING GUIDELINES

Formulator’s Edge: Unlike conventional crystalline Phloretin which is prone to recrystallization, sedimentation, and sudden color shifts, NanoActive Phloretin features excellent structural stability and effortless integration into diverse cosmetic chassis.

Recommended Use Level: 0.5% – 2.0% depending on the targeted performance profile (e.g., intensive whitening vs. daily antioxidant defense).

Optimal Formulation pH: Safe and stable across a broad pH span of 3.0 to 6.5. Optimum shelf stability is achieved between pH 4.5 and 6.5.

Processing Temperature: Cold processable. The product should preferably be incorporated during the final phase of manufacturing (cool-down stage) at temperatures below 45°C.

Incorporation Technique: Directly add to the aqueous phase under gentle stirring. Compatible with surfactant systems, hydrogels, O/W emulsions, and clear transparent serums without inducing recrystallization.

5. STORAGE, PACKAGING & SHELF LIFE

  • Packaging: Available in 1 kg, 5 kg, and 25 kg food-grade, UV-shielded polyethylene containers.
  • Storage Conditions: Store in the original sealed container at temperatures between 2°C and 25°C (refrigerated storage recommended for maximum lifecycle shelf-life). Keep away from direct sunlight, moisture, and localized heat sources.
  • Shelf Life: 12 months from the date of manufacture when stored strictly in compliance with recommended conditions.

6. REGULATORY & SAFETY PROFILE

Safety Assessment: Non-irritating to human skin (0.0% irritation index in patch testing). Non-phototoxic, non-sensitizing, and free from genetically modified organisms (GMO-free).

Compliance: INCI registered components. Globally compliant with EU, US FDA, and China NMPA safety technical standards for cosmetics.

NanoActive® BAKUCHIOL SALICYLATE: The Next-Gen Retinoid-Alternative for Dual-Action Care

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Introduction

As the dermo-cosmetic market shifts towards high-efficacy yet low-irritation solutions, the demand for “Retinol-like” performance without the associated “Retinol burn” has reached a peak. NanoActive® BAKUCHIOL SALICYLATE is a technologically advanced active that bridges the gap between anti-aging and blemish control.

By combining the terpenoid structure of Bakuchiol with the exfoliating and anti-inflammatory properties of Salicylic Acid, and subsequently encapsulating this conjugate within a biomimetic Nano-Delivery System (NDS), we offer a multi-dimensional tool for modern skincare. This system overcomes the inherent hydrophobic nature of the actives, providing a crystal-clear, water-soluble solution that penetrates deeply to reset cellular behavior.

The Technology: Synergistic Molecular Architecture

1. Molecular Functionalization

Unlike simple physical blends, NanoActive® BAKUCHIOL SALICYLATE leverages a synergistic approach where the anti-aging signaling of Bakuchiol and the keratolytic action of Salicylic Acid work in tandem. This conjugation maximizes the inhibition of pro-inflammatory cytokines while stimulating dermal matrix synthesis.

2. Nano-Encapsulation (NDS)

The active is embedded in a phospholipid-based nanosphere (average size < 100 nm). This provides:

  • Superior Stability: Prevents photo-oxidation and degradation.
  • Enhanced Bioavailability: Significant increase in transdermal flux compared to free-form Bakuchiol.
  • Non-Irritating Profile: Slow-release mechanism reduces the acute irritation often associated with salicylic acid, making it suitable for sensitive skin.

Biological Mechanisms & Efficacy

1. Dermal Matrix Restructuring

NanoActive® BAKUCHIOL SALICYLATE acts on the same gene pathways as Retinoids, upregulating Type I Collagen (COL1A1) and Type III Collagen, while suppressing the activity of MMP-1 to prevent collagen breakdown. It effectively reduces fine lines and improves skin elasticity.

2. Targeted Blemish Control & Pore Refinement

The salicylic acid moiety provides precise keratolytic action, clearing follicular debris. Simultaneously, the Bakuchiol component regulates sebum composition and inhibits the proliferation of Cutibacterium acnes, making it the ideal solution for adult acne and “maskne.”

3. Anti-Inflammatory & Soothing

By inhibiting the NF-κB signaling pathway, it calms chronic micro-inflammation (Inflamm-aging), reducing erythema and post-inflammatory hyperpigmentation (PIH).

Technical Specifications

Strategic Applications

  • Retinol-Alternative Elixirs: For consumers seeking ageless skin without the downtime of retinoids.
  • Blemish & Age Intercept Serums: Specifically designed for adult acne and skin texture refinement.
  • Glass Skin Foundations: Incorporating treatment benefits into high-clarity aqueous makeup bases.
  • Post-Procedure Recovery: To soothe and prevent pigmentation in sensitive skin types.

Disclaimer: This document is intended for B2B purposes only. All claims must be verified by the final formulator in accordance with regional cosmetic regulations.

Pioneering the Future of Skincare Efficacy

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At PuriPharm, we bridge the gap between advanced biomedical science and transformative cosmetic solutions. As a leading innovator in active ingredients and delivery architectures, we empower global personal care brands to achieve unprecedented clinical efficacy. Our core philosophy is built on two pillars: extracting the absolute potential of bioactive molecules, and ensuring their precise delivery to the target site.

Our Core Technology Matrix

PuriPharm’s innovation engine is driven by two flagship platforms, designed to work independently or in powerful synergy to elevate your formulations.

1. PuriActives®: The Pinnacle of Biological Efficacy

PuriActives® represents our premier line of highly purified, biologically active compounds. Rooted in synthetic biology, advanced fermentation, and precision extraction technologies, the PuriActives® portfolio delivers potent, mechanism-driven ingredients.

  • Uncompromised Purity: Rigorous isolation processes ensure that only the most active molecules are retained, minimizing impurities and maximizing safety.
  • Mechanism-Driven: Each active is developed with a clear understanding of cellular pathways, offering targeted solutions for anti-aging, pigmentation control, skin barrier repair, and microbiome balance.
  • Sustainable Sourcing: Inspired by nature and optimized in the lab, we minimize ecological impact while delivering consistent, scalable results.

Key Applications: Bio-mimetic Peptides, Recombinant Proteins, High-purity Botanical Extracts.

2. NanoActive®: Precision Delivery, Amplified Performance

The most potent active ingredient is only as effective as its ability to reach its target. NanoActive® is our proprietary, state-of-the-art nanotechnology delivery platform, engineered to overcome the thermodynamic and physiological barriers of the stratum corneum.

  • Enhanced Bioavailability: Utilizing advanced liposomal, solid lipid nanoparticle (SLN), and nano-emulsion architectures, NanoActive® dramatically increases the solubility and skin penetration of challenging active molecules.
  • Controlled & Sustained Release: Our carrier systems are designed for spatio-temporal precision, releasing the actives gradually to ensure long-lasting efficacy and lower irritation profiles.
  • Formulation Stability: By encapsulating sensitive compounds (e.g., Retinol, Vitamin C, Resveratrol), NanoActive® shields them from oxidation, light, and formulation incompatibilities, extending product shelf life.

The Science of Delivery: Nanostructured Lipid Carriers (NLC), Multi-lamellar Liposomes, Micro-sponges.

The Synergy of Science and Business

At PuriPharm, we do more than supply ingredients; we provide architectural solutions for your formulations. Whether you require the potent biological triggers of PuriActives® or the sophisticated delivery mechanisms of NanoActive®—or a customized integration of both—our team of scientists and market experts is ready to co-create your next hero product.

PuriPharm Co. Ltd. Innovating Molecules. Architecting Delivery. Transforming Beauty.

NanoActive® BAICALIN: The Intelligent “Telomerase” Activator for Cellular Youth

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Unleashing Baicalin’s Cellular Anti-Aging Potential through Advanced Nano-Targeted Delivery

1. Discovering Nature’s Time Code: Baicalin & The Delivery Bottleneck

Scutellaria baicalensis Georgi has long been revered as a “Golden Herb” in traditional Eastern medicine. Its core polyphenolic flavonoid active—Baicalin—has been extensively validated by top-tier SCI journals (e.g., Journal of Investigative Dermatology, Free Radical Biology and Medicine) for its outstanding pharmacological properties, including ROS scavenging, MMPs inhibition, and broad-spectrum UV protection.

However, in modern dermatology and premium cosmetic applications, unmodified Baicalin faces a notoriously difficult translational gap: stellarin vitrodata, but mediocrein vivoefficacy. This is driven by three critical challenges:

  • High Crystallinity & Poor Solubility: Highly prone to crystallization and precipitation in cosmetic emulsions or serums, making it impossible to maintain at high free-state concentrations.
  • Extreme Physicochemical Instability: Containing multiple oxidation-prone phenolic hydroxyl groups, it easily browns and develops off-odors when exposed to light, heat, or mildly alkaline formulations.
  • Extremely Low Bioavailability: Its large molecular polarity means it is heavily blocked by the dense “brick-and-mortar” structure of the Stratum Corneum, failing to penetrate into the dermis to exert gene-level targeted effects.

PuriPharm: The NanoActive® Targeted Intelligent Delivery Solution

Fusing biomimetic medicine with nanofluidic dynamics, PuriPharm utilizes its proprietary NanoActive® encapsulation technology. We have constructed Multilamellar Vesicles that highly mimic the structure of human cell membranes, precisely and stably embedding high-purity Baicalin within an amphiphilic nano-bilayer structure.

This breakthrough technology completely dismantles Baicalin’s physical barriers, achieving a systemic quadruple leap: High Solubility, Supreme Stability, Targeted Deep Penetration, and Prolonged Sustained Release.

2. Core Mechanism of Action (MoA): Targeting the Root of Cellular Senescence

Leveraging the highly efficient transmembrane fusion capabilities of the NanoActive® carrier, Baicalin can reach efficacious therapeutic concentrations inside living cells, exerting critical regulatory roles across three cutting-edge anti-aging pathways:

2.1 Targeted Telomerase Activation, Guarding the DNA Terminal Lifeline

Nobel Prize-winning research indicates that replicative cellular senescence is dictated by the “biological clocks” at the ends of chromosomes—Telomeres. UV irradiation and chronic oxidative stress dramatically accelerate telomere shortening, leading to irreversible cellular senescence.

  • Upregulation of TERT Genes: NanoActive® BAICALIN penetrates deep into the nucleus to specifically activate or maintain the expression levels of Telomerase Reverse Transcriptase (TERT).
  • Rescuing G1 Phase Arrest: It significantly downregulates core senescence switch genes p53 and p16INK4a (induced by DNA damage), enabling dormant senescent cells to regain their capacity for division and self-renewal, effectively turning back the clock at the genetic level.

2.2 Reversing SASP (Senescence-Associated Secretory Phenotype) — Cellular “Senomorphics”

In modern anti-aging medicine, clearing or modifying the toxic factors secreted by senescent cells (SASP, e.g., IL-6, IL-8, MMPs) is the most sought-after strategy.

NanoActive® BAICALIN demonstrates potent “Senomorphic” activity. It strongly inhibits the NF-κB inflammatory signaling pathway, severing the contagious cascade of SASP that destroys the surrounding healthy Extracellular Matrix (ECM), thereby protecting the Type I and Type III collagen networks.

2.3 Awakening the Nrf2/ARE Antioxidant Master Switch

Transcending the limitations of traditional antioxidants (like Vitamin C and E) which consume themselves in a 1:1 ratio with free radicals, NanoActive® BAICALIN acts as an “ignition key” for the cell’s endogenous defense mechanisms. By dissociating the Keap1-Nrf2 complex, it promotes Nrf2 nuclear translocation and binding to the ARE sequence, exponentially amplifying the expression of endogenous antioxidant enzymes (SOD, CAT, GSH-Px).

3. Outstanding Scientific Efficacy: Defining Anti-Aging Limits with Data

3.1 Nano-Targeted Delivery & Kinetics

Experiment A: HaCaT Cellular Internalization

Assessed using fluorescent probes (Coumarin-6) combined with flow cytometry and confocal microscopy.

●Results: After a 2-hour incubation, the absolute intracellular fluorescence intensity of the NanoActive® group was 4.2 times higher than that of the unencapsulated free Baicalin group. The biomimetic liposomes seamlessly fused via endocytosis, achieving highly efficient “targeted airdrops.”

Experiment B: Franz Diffusion Cell & Higuchi Release Model

●Penetration: The cumulative amount of Baicalin penetrating the porcine ear epidermis into the receptor fluid over 24 hours was 8.5 times greater for NanoActive® BAICALIN compared to standard Baicalin raw materials.

●Release Profile: The release curve perfectly aligns with the Higuchi Diffusion Equation (R² > 0.98), exhibiting characteristic matrix-type sustained release. It delivers a steady release over 24 hours, avoiding the “peak and valley” effect of drug concentration to ensure long-lasting, gentle, and effective results.

3.2 In Vitro & 3D Ex Vivo Skin Models

Experiment C: Fibroblast Telomerase Activity Protection (TRAP Assay)

Human primary fibroblasts were exposed to a UVA photo-damage model.

●Results: UVA reduced fibroblast telomerase activity to 31.2% of the normal group. Following pretreatment with NanoActive® BAICALIN, telomerase activity recovered to 63.9%, confirming its direct protective effect on the TERT mechanism.

Experiment D: 3D Full-Thickness Skin Model Remodeling

Continuous topical application of the test substance on a reconstructed 3D skin model for 7 days.

●Results: H&E staining and immunofluorescence of tissue sections showed that, compared to the control group, the NanoActive® BAICALIN treated group exhibited a 17% increase in epidermal thickness, a 145% enhancement in the fluorescence expression intensity of Pro-collagen I in the dermis, and a significantly denser and more undulated Dermal-Epidermal Junction (DEJ) architecture.

3.3 In Vivo Clinical Efficacy

●Study Design: A randomized, double-blind, placebo-controlled clinical trial. 35 female subjects aged 35-55 with moderate photoaging and wrinkles applied a base cream containing 2% NanoActive® BAICALIN to half of their face twice daily for 56 days. Instrumental evaluations included VISIA®-CR, Cutometer®, and high-frequency skin ultrasound.

Core Clinical Data:

  1. Leap in Dermal Density (Skin Density via Ultrasound): Evaluated using a 20 MHz high-frequency ultrasound scan. After 56 days of use, the dermal density significantly increased by 19.3% (measured by the reduction of the Subepidermal Low Echogenic Band, SLEB), proving substantial remodeling of the collagen network.
  2. Deep Wrinkle Reduction & Smoothing: Maximum depth of crow’s feet wrinkles (Rz) was reduced by 22.4%, and skin roughness (Ra) decreased by 16.5%.
  3. Potent Soothing & Anti-Inflammaging (Erythema Index): The skin Erythema Index showed a significant drop as early as day 14 (-11%), with a cumulative reduction of 18% over 56 days, clinically validating its soothing efficacy against micro-inflammation induced by SASP.

4. Technical Advantages & Formulation Guidelines

NanoActive® BAICALIN is a “plug-and-play” bioactive designed for high-end skincare products pursuing ultimate clinical efficacy.

  • INCI Name: Scutellaria Baicalensis Root Extract
  • Appearance: Light yellow to brownish-yellow translucent nano-fluid.
  • Particle Size: 10-100nm (DLS detection, PDI < 0.2). This ultra-small particle size is the core of its transparent appearance and deep transdermal penetration.
  • Superior Formulation Compatibility:
  • Disperses perfectly in the aqueous phase; zero crystallization or precipitation over time.
  • Broad pH tolerance range (pH 4.0 – 7.5).
  • Ease of Use: Cold processable; can be added directly to the water phase. For hot emulsion systems, addition is recommended during the cooling phase post-homogenization (< 45°C).

●Extreme Stability Challenge: Under accelerated testing for 3 months at 40°C and 5000 Lux illumination, the active retention rate of Baicalin in NanoActive® BAICALIN was> 95%, with zero browning and zero off-odors (Note: unencapsulated Baicalin severely degrades and discolors within 15 days under identical conditions).

Market Positioning & Applications (Claims):

  • Recommended Dosage: Daily maintenance and early anti-aging (0.5% – 2.0%); Targeted telomerase activation, intensive anti-wrinkle, and photo-damage repair (2.0% – 5.0%).
  • Marketing Claims: Telomerase Guardian, Cellular Longevity Extension, Senolytics/Senomorphics, Photoaging Reversal, Non-Destructive Deep Delivery.
  • Applicable Formats: Premium anti-aging creams, gene-repair base serums, high-potency antioxidant sunscreens, post-microneedling/laser wound-healing serums, luxury scalp anti-aging and anti-hair-loss tonics.

NanoActive® BAICALIN— The underlying engine for international cutting-edge cellular skincare.

Researched and Manufactured by PuriPharm. Fusing macromolecular delivery kinetics with systems biomedicine to rewrite time and unlock the secrets of ageless skin.

PuriActives® Ursolene™ BZ (Benzyl Ursolate)

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Precision-Engineered Triterpenoid: The Cornerstone of Deep Dermal Rejuvenation & Structural Reconstruction

1. Product Overview

While natural pentacyclic triterpenes (like Ursolic Acid) are renowned for their exceptional biological activities, their cosmetic application has historically been bottlenecked by extremely poor lipophilicity, low skin penetration, and formulation instability (propensity to crystallize).

Enter PuriActives® Ursolene™ BZ (INCI: Benzyl Ursolate). By introducing a benzyl group to the ursolic acid backbone, we have fundamentally shifted the molecule’s partition coefficient ( log P). This precise structural modification transforms a traditional botanical extract into a highly bioavailable, oil-soluble powerhouse. It precisely targets the Extracellular Matrix (ECM) architecture, offering a definitive solution for intrinsic/extrinsic aging, loss of elasticity, and compromised skin barriers.

The Core Edge: The perfect synergy of a naturally derived core and rational structural design, bridging the gap between pharmaceutical-grade precision and cosmetic applicability.

2. Key Biological Pathways & Mechanism of Action

PuriActives® Ursolene™ BZ operates through a multi-target mechanism, mitigating tissue senescence at the cellular level:

MMP Modulation & ECM Protection: Acts as a potent competitive inhibitor of Matrix Metalloproteinases (specifically MMP-1 and MMP-9), halting the enzymatic degradation cascade of collagen and elastin networks.

Fibroblast Activation via TGF-β Pathway: Stimulates the transforming growth factor-beta (TGF-β) signaling pathway, upregulating COL1A1 and COL3A1 gene expression to drive the de novo synthesis of structural proteins.

Inflammaging Mitigation: Suppresses the cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) pathways, interrupting the chronic micro-inflammatory cascades that accelerate tissue aging.

Epidermal Lipid Biosynthesis: Upregulates serine palmitoyltransferase (SPT) activity, driving endogenous ceramide production to fortify the stratum corneum barrier.

3. Proven Efficacy (In Vitro & In Vivo Highlights)

Our rigorous efficacy testing matrix demonstrates statistically significant improvements compared to vehicle and unmodified free ursolic acid controls.

In Vitro: Dermal Architecture Support

  • + 42% Increase in Pro-collagen I synthesis (Primary human fibroblasts, at 10μM, ).
  • – 65% Reduction in UV-induced elastase activity, effectively preserving skin recoil capacity.

In Vivo Clinical Study: Facial Micro-Topography (28-Day Study)

A double-blind, placebo-controlled clinical study on 30 female volunteers (aged 45-65), applying a 0.2% PuriActives® Ursolene™ BZ cream twice daily.

● Wrinkle Depth (Ra): Significant reduction of 21.4% in the periocular region.

● Skin Density: Ultrasound imaging revealed a +15% increase in dermal echogenicity, indicating structural redensification of the dermis.

4. Formulation & Technical Guidelines

PuriActives® Ursolene™ BZ is engineered for the ultimate formulator experience. Its esterified structure completely circumvents the notorious crystallization issues of free ursolic acid, enabling the creation of highly stable, cosmetically elegant emulsions.

● INCI Name: Benzyl Ursolate

● Appearance: White to off-white crystalline powder

● Solubility: Soluble in cosmetic esters (e.g., Caprylic/Capric Triglyceride, Squalane), ethanol, and glycols. Insoluble in water.

● Recommended Usage Level: 0.05% – 0.30%

● Formulation Integration: Add to the heated oil phase ( 70~80℃ ) and stir until fully dissolved before emulsification.

● Optimal pH Range: 4.5 – 6.5

5. Sustainability & Purity

PuriActives® Ursolene™ BZ is derived from upcycled apple pomace and rosemary extract precursors, synthesized via a highly efficient, atom-economical esterification process. We guarantee an ultra-high purity active (HPLC ＞ 95%) while minimizing our environmental footprint.

Recommended Applications:

● Premium Anti-Aging Night Creams

● Intensive Barrier Repair Serums

● Dermo-cosmetics (Post-Procedure Care)

● Sun Recovery & “Anti-Inflammaging” Formulations

NanoActive DHM

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Scientific Breakthrough: Epigenetic Anti-AgingDeveloped byPuriPharmCo. Ltd.

1. Epigenetics and Skin Aging

What is Epigenetics?

Epigenetics is the science studying how lifestyle and environmental factors influence gene expression.

This process occurs without changing the underlying DNA sequence.

Instead, it alters gene activity by turning genes “on” or “off” based on external stimuli.

It provides a profound new target for anti-aging interventions by addressing the root causes of cellular decline.

The Identical Twins Study

Primary Drivers of Skin Aging

The Process of DNA Methylation

Lifestyle and environmental factors influence gene expression primarily through DNA methylation.

Methyl groups (epigenetic factors) attach to the DNA molecule.

These methylation marks can activate or, more commonly in aging, improperly repress or “silence” specific genes.

This makes the DNA inaccessible to the machinery that keeps cells youthful and functional.

Hypermethylation and Aging

2. The DHM Breakthrough

Introducing Dihydromyricetin: The world’s first cosmetic DNA methylation inhibitor.

A Global Innovation

Dihydromyricetin (DHM)：

NanoActive DHM features Dihydromyricetin, globally recognized as the first cosmetic ingredient scientifically proven to inhibit DNA methylation. This represents a paradigm shift, leading a completely new direction in epigenetic anti-aging interventions.

Mechanism of Action

Inhibit Methylation: DHM acts directly at the genetic level to regulate and inhibit the excessive DNA methylation patterns that accumulate over time.

Reactivate Youth Genes: By removing these inhibitory methyl tags, DHM successfully reactivates silenced youth genes.

Restore Vitality: This fundamentally delays cellular aging by returning skin cells to their peak functional state, rather than just treating surface symptoms.

Natural Plant Source

NanoActive DHM is extracted exclusively from Ampelopsis Grossedentata, commonly known as Vine Tea.

It belongs to the Vitaceae family, Ampelopsis genus.

This specific plant is exceptionally rich in naturally occurring Dihydromyricetin.

It provides a clean, sustainable, and highly potent botanical source for epigenetic anti-aging formulations.

Cultivation & Extraction

3. Advanced Nanoliposome Technology

Nanoliposome Principles

Definition: Nanoliposomes are microscopic vesicles composed of phospholipid bilayers that perfectly mimic the human cell membrane structure.

Average Size: Ranging from 10 to 50 nm, they are perfectly sized to penetrate the skin barrier effectively.

Encapsulation: They possess a high drug entrapment efficiency, capable of securely encapsulating both hydrophobic and hydrophilic active ingredients like DHM.

Technology Advantages

The Dual Breakthrough

4. Clinical Efficacy and Validation

DNA Methylation Impact

Reversing the Clock

Under experimental conditions (20µM DHM over 6 weeks on a skin equivalent model), DHM treatment significantly affected over 10,000 methylation sites. It successfully induced a young epidermal DNA methylation pattern, restoring youthful epigenetic characteristics.

Epidermal Structure Improvement

Reactivation of Youth Genes

5. Market Application & Value

Competitive Advantage

Target Market & Applications

NanoActive Sulfur PRODUCT DATA SHEET

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Advanced Nano-Encapsulated Bio-Derived Sulfur for Multi-Targeted Skin Solutions

Company: PuriPharm Co. Ltd.

Website: www.PuriActives.com

Contact: Service@puripharm.com | Tel: 13167223168

1. PRODUCT OVERVIEW

Sulfur is a naturally occurring nonmetal with a long-standing dermatological history of effectively treating various skin disorders. However, traditional sulfur applications are severely limited by poor water solubility, large particle sizes (2–5 μm), low bioavailability, and formulation challenges.

NanoActive Sulfur, developed by PuriPharm Co. Ltd., is a cutting-edge active ingredient that utilizes a proprietary Nano-Delivery System (NDS). By stably encapsulating highly active bio-derived sulfur into sub-30 nm lipid-based nanocarriers, it completely resolves traditional solubility and aesthetic issues. The result is a highly bioavailable, transparent, and universally compatible active that regulates sebum, reduces inflammation, and offers potent antibacterial properties for acne and scalp care.

2. COMPOSITION & INCI INFORMATION

NanoActive Sulfur is formulated using a specialized biomimetic lipid matrix designed for optimal trans-epidermal delivery. It is strictly free from added preservatives and antioxidants.

Composition Range Table:

3. TECHNICAL SPECIFICATIONS

4. TECHNOLOGY HIGHLIGHTS: THE NDS ADVANTAGE

  • Ultra-Fine Particle Size (< 30 nm): Significantly increases the specific surface area and interaction with keratinocytes, ensuring superior skin penetration and biological activity compared to traditional 2-5 μm sulfur.
  • Exceptional Formulation Flexibility: The unique hydrophilic-lipophilic structural modification allows NanoActive Sulfur to be seamlessly incorporated into lotions, creams, clear gels, and water-based formulas without precipitation.
  • Aesthetic Superiority: Unlike traditional sulfur, which is chalky and difficult to suspend, NanoActive Sulfur maintains optical clarity (forming a transparent solution at typical usage levels), leaving no residue and enabling elegant cosmetic formulations.
  • High Stability & Bioavailability: The robust phospholipid-based nanocarrier prevents aggregation, protects the active payload, and ensures targeted delivery to the sebaceous glands and follicles.

5. KEY COSMETIC BENEFITS & MECHANISM OF ACTION

A. Comprehensive Sebum Regulation & Keratolysis

Excessive sebum accumulation leads to enlarged pores, follicular blockage, and inflammation. NanoActive Sulfur effectively removes surface lipids, softens the epidermis, and dissolves keratin plugs.

●Mechanism:At low concentrations, sulfur exerts a keratoplastic effect, promoting normal keratinization. At higher concentrations, it becomes keratolytic, reacting with cysteine to form cystine and hydrogen sulfide (), which safely disrupts excess keratin and clears clogged pores.

B. Targeted Antibacterial & Antifungal Action

NanoActive Sulfur acts as a potent purifying agent and helps rebalance the skin microbiome.

●Mechanism: Skin bacteria and keratinocytes convert sulfur into pentathionic acid (), a compound highly toxic to fungi and pathogenic bacteria. The keratolytic action further helps detach microorganisms from the stratum corneum.

●Microbiological Efficacy (In Vitro):

○P. aeruginosa: MIC = 1.95 μg/mL | MBC = 1000 μg/mL

○S. aureus: MIC = 125 μg/mL

○E. coli: MIC = 500 μg/mL

C. Powerful Anti-Inflammatory & Soothing Properties

Severe oxidative stress depletes intracellular Glutathione (GSH), triggering inflammatory cascades.

●Mechanism:NanoActive Sulfur supports cellular antioxidant defenses by promoting GSH synthesis.

●Efficacy:Exerts a strong, dose-dependent reduction in the expression of key pro-inflammatory cytokines. Clinical evaluations (ELISA) show that concentrations between 0.1% and 0.4% significantly downregulate the protein expression ofIL-1β,IL-6, and TNF-α.

D. Clinically Proven Acne Treatment

Inin-vivoassessments, formulations containing NanoActive Sulfur demonstrated visible improvement in acne-prone skin profiles. A 60-day application of 0.2% active showed a significant reduction in inflammatory lesions and post-acne erythema, making it an ideal candidate for long-term acne management.

6. RECOMMENDED APPLICATIONS

NanoActive Sulfur is highly versatile and is recommended for the following cosmetic product categories:

  • Acne & Blemish Control: Spot treatments, anti-acne serums, and purifying toners.
  • Sebum Control & Pore Refining: Mattifying lotions, oil-control powders, and deep-cleansing masks.
  • Brightening & Spot-Fading: Post-inflammatory hyperpigmentation (PIH) correctors.
  • Scalp Care: Anti-dandruff shampoos and scalp-soothing serums (seborrheic dermatitis support).
  • Soothing & Repair: Products targeting sensitized, inflamed, or compromised skin barriers.

7. FORMULATION GUIDANCE

  • Suggested Use Level: 0.1% – 5.0% (Depending on target efficacy: low doses for daily maintenance/anti-inflammation; higher doses for targeted spot treatments).
  • Solubility: Amphiphilic nature allows it to be easily added to either the aqueous phase or the final emulsion at room temperature or gently heated conditions.
  • Compatibility: Compatible with a wide range of cosmetic ingredients, including traditional water-based and oil-based systems. Does not cause phase separation.

8. STORAGE, HANDLING & PACKAGING

  • Storage: Store in the original, unopened container at 4°C to 25°C. Protect from direct sunlight and maintain in a dry environment.
  • Shelf Life: 12 months under specified storage conditions.
  • Packaging: Supplied in standard industrial plastic containers.

Disclaimer: The information contained in this document is provided in good faith and is based on our current knowledge and internal testing. Formulators are responsible for ensuring the final cosmetic product’s stability, safety, and regulatory compliance in their respective target markets.

PuriPharm Co. Ltd. | Advanced Active Ingredients