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PuriActives® Ursolene™ BZ (Benzyl Ursolate)

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Precision-Engineered Triterpenoid: The Cornerstone of Deep Dermal Rejuvenation & Structural Reconstruction

1. Product Overview

While natural pentacyclic triterpenes (like Ursolic Acid) are renowned for their exceptional biological activities, their cosmetic application has historically been bottlenecked by extremely poor lipophilicity, low skin penetration, and formulation instability (propensity to crystallize).

Enter PuriActives® Ursolene™ BZ (INCI: Benzyl Ursolate). By introducing a benzyl group to the ursolic acid backbone, we have fundamentally shifted the molecule’s partition coefficient ( log P). This precise structural modification transforms a traditional botanical extract into a highly bioavailable, oil-soluble powerhouse. It precisely targets the Extracellular Matrix (ECM) architecture, offering a definitive solution for intrinsic/extrinsic aging, loss of elasticity, and compromised skin barriers.

The Core Edge: The perfect synergy of a naturally derived core and rational structural design, bridging the gap between pharmaceutical-grade precision and cosmetic applicability.

2. Key Biological Pathways & Mechanism of Action

PuriActives® Ursolene™ BZ operates through a multi-target mechanism, mitigating tissue senescence at the cellular level:

MMP Modulation & ECM Protection: Acts as a potent competitive inhibitor of Matrix Metalloproteinases (specifically MMP-1 and MMP-9), halting the enzymatic degradation cascade of collagen and elastin networks.

Fibroblast Activation via TGF-β Pathway: Stimulates the transforming growth factor-beta (TGF-β) signaling pathway, upregulating COL1A1 and COL3A1 gene expression to drive the de novo synthesis of structural proteins.

Inflammaging Mitigation: Suppresses the cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) pathways, interrupting the chronic micro-inflammatory cascades that accelerate tissue aging.

Epidermal Lipid Biosynthesis: Upregulates serine palmitoyltransferase (SPT) activity, driving endogenous ceramide production to fortify the stratum corneum barrier.

3. Proven Efficacy (In Vitro & In Vivo Highlights)

Our rigorous efficacy testing matrix demonstrates statistically significant improvements compared to vehicle and unmodified free ursolic acid controls.

In Vitro: Dermal Architecture Support

  • + 42% Increase in Pro-collagen I synthesis (Primary human fibroblasts, at 10μM, ).
  • – 65% Reduction in UV-induced elastase activity, effectively preserving skin recoil capacity.

In Vivo Clinical Study: Facial Micro-Topography (28-Day Study)

A double-blind, placebo-controlled clinical study on 30 female volunteers (aged 45-65), applying a 0.2% PuriActives® Ursolene™ BZ cream twice daily.

● Wrinkle Depth (Ra): Significant reduction of 21.4% in the periocular region.

● Skin Density: Ultrasound imaging revealed a +15% increase in dermal echogenicity, indicating structural redensification of the dermis.

4. Formulation & Technical Guidelines

PuriActives® Ursolene™ BZ is engineered for the ultimate formulator experience. Its esterified structure completely circumvents the notorious crystallization issues of free ursolic acid, enabling the creation of highly stable, cosmetically elegant emulsions.

● INCI Name: Benzyl Ursolate

● Appearance: White to off-white crystalline powder

● Solubility: Soluble in cosmetic esters (e.g., Caprylic/Capric Triglyceride, Squalane), ethanol, and glycols. Insoluble in water.

● Recommended Usage Level: 0.05% – 0.30%

● Formulation Integration: Add to the heated oil phase ( 70~80℃ ) and stir until fully dissolved before emulsification.

● Optimal pH Range: 4.5 – 6.5

5. Sustainability & Purity

PuriActives® Ursolene™ BZ is derived from upcycled apple pomace and rosemary extract precursors, synthesized via a highly efficient, atom-economical esterification process. We guarantee an ultra-high purity active (HPLC ＞ 95%) while minimizing our environmental footprint.

Recommended Applications:

● Premium Anti-Aging Night Creams

● Intensive Barrier Repair Serums

● Dermo-cosmetics (Post-Procedure Care)

● Sun Recovery & “Anti-Inflammaging” Formulations

NanoActive DHM

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NanoActive DHM Epigenetic Youth Restorer & DNA Methylation Inhibitor

1. PRODUCT IDENTIFICATION

  • Product Name: NanoActive DHM
  • Trade Name: NanoActive DHM by PuriPharm
  • INCI Name: Water, Glycerin, Caprylic/Capric Triglyceride, Ampelopsis Grossedentata Extract, Phospholipids, Tocopheryl Acetate.
  • Botanical Source of Active: Ampelopsis grossedentata(Vine Tea)
  • Active Content: 9.5% – 10.5% (Ampelopsis Grossedentata Extract)

2. PRODUCT DESCRIPTION

NanoActive DHM represents a paradigm shift in epigenetic anti-aging. Developed by PuriPharm Co. Ltd., it is the industry’s first cosmetically viable DNA methylation inhibitor. Utilizing advanced nanoliposomal technology, highly purified Dihydromyricetin (DHM) is encapsulated in a biomimetic phospholipid bilayer. This sophisticated delivery system overcomes the inherent instability and poor skin penetration of DHM, allowing for targeted delivery to the deep epidermis and dermis, fundamentally reversing cellular aging at the genetic transcription level.

3. MECHANISM OF ACTION

Environmental stressors (UV, pollution) and intrinsic aging lead to hypermethylation of DNA, which functionally “silences” essential youth and structural genes.

  • Epigenetic Reversal: NanoActive DHM acts as a potent DNA methylation inhibitor, effectively removing age-induced methyl tags.
  • Gene Reactivation: By modulating over 10,000 methylation sites, it reactivates silenced genes associated with the Extracellular Matrix (ECM), signal transduction, and autophagy.
  • Targeted Delivery: The 50-150 nm liposomal spheres ensure enhanced transdermal absorption and a sustained-release profile, maximizing biological availability and minimizing potential irritation.

4. TECHNICAL SPECIFICATIONS

5. EFFICACY & CLINICAL DATA SUMMARY

  • Transcriptomic Upregulation: Significantly upregulates key structural genes including COL6A1 (Collagen Type VI), ITGB6, ITGA5, and VCL, restoring cellular anchorage and tissue firmness.
  • 3D Skin Equivalent Model: In a 6-week in vitrostudy utilizing 20µM DHM on mature 3D skin models, NanoActive DHM effectively reversed epidermal thinning. Epidermal thickness increased from 30µm (untreated mature control) to ~50µm, closely mirroring the baseline of young skin models (60µm). Statistical significance achieved (p = 0.00064).

6. FORMULATION GUIDELINES

NanoActive DHM is designed for ease of use in premium cosmetic formulations.

  • Recommended Usage Level: 1.0% – 5.0%
  • Incorporation Phase: Add to the aqueous phase or during the cooling phase (below 45°C) for emulsions to maintain liposomal integrity.
  • pH Compatibility: Stable within a final formulation pH range of 4.5 – 7.5.
  • Incompatibilities: Avoid high concentrations of strong ionic surfactants or extreme ethanol levels (>20%) which may disrupt the lipid bilayer.
  • Processability: Do not subject to intense, prolonged shear force (homogenization > 3000 rpm for extended periods) after incorporation.

7. TARGET APPLICATIONS

  • Premium Anti-Aging Skincare: Serums, night creams, and eye treatments targeting chronological aging and photoaging.
  • Medical Aesthetics Post-Care: Restorative formulations designed to prolong the effects of clinical treatments by maintaining epigenetic cellular health.
  • Preventative Aging: Solutions targeting millennials/Gen-Z exposed to urban pollution, stress, and lifestyle-induced epigenetic damage.

8. STORAGE & SHELF LIFE

  • Storage Conditions: Store in a cool, dry place away from direct sunlight. Recommended storage temperature: 4°C – 25°C. Do not freeze. Keep containers tightly sealed when not in use.
  • Shelf Life: 24 months from the date of manufacture under optimal storage conditions.

Disclaimer: The information provided herein is based on our current knowledge and rigorous scientific testing. It is intended for informational purposes for cosmetic professionals and formulators. It is the responsibility of the formulator to ensure the stability, safety, and regulatory compliance of the final consumer product.

PuriPharm Co. Ltd.Pioneering Epigenetic Skincare SolutionsWebsite: www.puriactives.com | Email: service@puripharm.com

NanoActive DHM

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Scientific Breakthrough: Epigenetic Anti-AgingDeveloped byPuriPharmCo. Ltd.

1. Epigenetics and Skin Aging

What is Epigenetics?

Epigenetics is the science studying how lifestyle and environmental factors influence gene expression.

This process occurs without changing the underlying DNA sequence.

Instead, it alters gene activity by turning genes “on” or “off” based on external stimuli.

It provides a profound new target for anti-aging interventions by addressing the root causes of cellular decline.

The Identical Twins Study

Primary Drivers of Skin Aging

The Process of DNA Methylation

Lifestyle and environmental factors influence gene expression primarily through DNA methylation.

Methyl groups (epigenetic factors) attach to the DNA molecule.

These methylation marks can activate or, more commonly in aging, improperly repress or “silence” specific genes.

This makes the DNA inaccessible to the machinery that keeps cells youthful and functional.

Hypermethylation and Aging

2. The DHM Breakthrough

Introducing Dihydromyricetin: The world’s first cosmetic DNA methylation inhibitor.

A Global Innovation

Dihydromyricetin (DHM)：

NanoActive DHM features Dihydromyricetin, globally recognized as the first cosmetic ingredient scientifically proven to inhibit DNA methylation. This represents a paradigm shift, leading a completely new direction in epigenetic anti-aging interventions.

Mechanism of Action

Inhibit Methylation: DHM acts directly at the genetic level to regulate and inhibit the excessive DNA methylation patterns that accumulate over time.

Reactivate Youth Genes: By removing these inhibitory methyl tags, DHM successfully reactivates silenced youth genes.

Restore Vitality: This fundamentally delays cellular aging by returning skin cells to their peak functional state, rather than just treating surface symptoms.

Natural Plant Source

NanoActive DHM is extracted exclusively from Ampelopsis Grossedentata, commonly known as Vine Tea.

It belongs to the Vitaceae family, Ampelopsis genus.

This specific plant is exceptionally rich in naturally occurring Dihydromyricetin.

It provides a clean, sustainable, and highly potent botanical source for epigenetic anti-aging formulations.

Cultivation & Extraction

3. Advanced Nanoliposome Technology

Nanoliposome Principles

Definition: Nanoliposomes are microscopic vesicles composed of phospholipid bilayers that perfectly mimic the human cell membrane structure.

Average Size: Ranging from 10 to 50 nm, they are perfectly sized to penetrate the skin barrier effectively.

Encapsulation: They possess a high drug entrapment efficiency, capable of securely encapsulating both hydrophobic and hydrophilic active ingredients like DHM.

Technology Advantages

The Dual Breakthrough

4. Clinical Efficacy and Validation

DNA Methylation Impact

Reversing the Clock

Under experimental conditions (20µM DHM over 6 weeks on a skin equivalent model), DHM treatment significantly affected over 10,000 methylation sites. It successfully induced a young epidermal DNA methylation pattern, restoring youthful epigenetic characteristics.

Epidermal Structure Improvement

Reactivation of Youth Genes

5. Market Application & Value

Competitive Advantage

Target Market & Applications

LipoEcdysone™ PRO: The Biomimetic Phytosteroid Revolution

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Advanced Liposomal Hydroxyecdysone for High-Performance Cosmetics & Nutraceuticals

1. Product Concept: Unlocking Nature’s Blueprint

Hydroxyecdysone (20-HE) is a highly potent phytosteroid naturally found in select adaptogenic plants. Renowned for its extraordinary ability to stimulate cellular vitality and protein synthesis, its traditional application has been limited by poor solubility and low bioavailability.

Enter LipoEcdysone™ PRO. By utilizing cutting-edge, pharmaceutical-grade liposomal encapsulation technology, we have engineered a highly stable, bioavailable delivery system. Our biomimetic phospholipid vesicles seamlessly integrate with human cell membranes, ensuring deep tissue penetration and targeted active release—bridging the gap between natural potential and ultimate clinical efficacy.

2. The Liposomal Advantage: Science Meets Delivery

Standard Hydroxyecdysone struggles to cross the stratum corneum in skin or survive enzymatic degradation in the gut. Our proprietary liposomal matrix solves this:

  • Biomimetic Penetration: Phospholipid bilayers mimic cellular structures, facilitating endocytosis and direct intracellular delivery.
  • Enhanced Stability: Protects the active phytosteroid from oxidation, pH variations, and metabolic breakdown.
  • Sustained Release: Controlled time-release mechanism prevents active degradation and prolongs biological efficacy.

3. Cosmetic Applications (Personal Care)

Architecting Skin Density & Resilience from Within

In cosmetic formulations, LipoEcdysone™ PRO acts as a powerful anti-aging and skin-restoring agent. It stimulates the skin’s natural regenerative pathways without the side effects associated with synthetic retinoids.

Key Mechanisms & Benefits:

  • Epidermal Reinforcement: Accelerates keratinocyte differentiation, fortifying the skin barrier and increasing epidermal thickness.
  • Dermal Matrix Redensification: Up-regulates the synthesis of Collagen I and III, effectively improving skin elasticity and smoothing deep wrinkles.
  • Micro-Wound Healing: Ideal for post-procedure or compromised skin, promoting rapid tissue repair through enhanced cellular crosstalk.

Recommended Applications: Anti-aging serums, skin-barrier repair creams, post-treatment recovery lotions, and firming body care.

4. Nutraceutical Applications (Functional Foods & Supplements)

The Ultimate Natural Anabolic & Metabolic Adaptogen

For the sports nutrition and longevity markets, LipoEcdysone™ PRO delivers unparalleled systemic benefits. By significantly increasing oral bioavailability, lower dosages achieve superior physiological results.

Key Mechanisms & Benefits:

  • Muscle Protein Synthesis (MPS): Activates the PI3K/Akt signaling pathway, promoting lean muscle mass accretion and accelerating recovery post-exercise.
  • Metabolic Homeostasis: Acts as a powerful adaptogen, supporting glucose metabolism and mitigating the physical markers of stress.
  • Joint & Cartilage Support: Exhibits anti-inflammatory properties, preserving extracellular matrix integrity in joints for aging populations and athletes.

Recommended Applications: Sports recovery shots, longevity capsules, adaptogenic functional beverages, and joint-health gummies.

5. Technical Specifications & Formulation Guidelines

  • INCI Name: Phospholipids (and) PHYTOECDYSTEROIDS.
  • Appearance: Translucent to slightly opalescent fluid.
  • Particle Size (D50): < 150 nm (Ensuring optimal cellular uptake).
  • Solubility: Dispersible in water; compatible with both hydrophilic and lipophilic systems.
  • Recommended Use Level: * Cosmetics: 1.0% – 5.0% (Add during the cooling phase, below 40°C).

Nutraceuticals: Please refer to local regulatory guidelines for dietary supplement dosing.

  • Preservative System:Self-preserving / Preservative-free options available.
  • Sustainability: Ethically sourced botanical extracts, solvent-free liposomal extrusion process, 100% vegan and cruelty-free.

Disclaimer: The information provided is for B2B educational purposes. Finished product claims must be evaluated by the respective legal and regulatory bodies of the target markets.

NanoActive Sulfur PRODUCT DATA SHEET

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Advanced Nano-Encapsulated Bio-Derived Sulfur for Multi-Targeted Skin Solutions

Company: PuriPharm Co. Ltd.

Website: www.PuriActives.com

Contact: Service@puripharm.com | Tel: 13167223168

1. PRODUCT OVERVIEW

Sulfur is a naturally occurring nonmetal with a long-standing dermatological history of effectively treating various skin disorders. However, traditional sulfur applications are severely limited by poor water solubility, large particle sizes (2–5 μm), low bioavailability, and formulation challenges.

NanoActive Sulfur, developed by PuriPharm Co. Ltd., is a cutting-edge active ingredient that utilizes a proprietary Nano-Delivery System (NDS). By stably encapsulating highly active bio-derived sulfur into sub-30 nm lipid-based nanocarriers, it completely resolves traditional solubility and aesthetic issues. The result is a highly bioavailable, transparent, and universally compatible active that regulates sebum, reduces inflammation, and offers potent antibacterial properties for acne and scalp care.

2. COMPOSITION & INCI INFORMATION

NanoActive Sulfur is formulated using a specialized biomimetic lipid matrix designed for optimal trans-epidermal delivery. It is strictly free from added preservatives and antioxidants.

Composition Range Table:

3. TECHNICAL SPECIFICATIONS

4. TECHNOLOGY HIGHLIGHTS: THE NDS ADVANTAGE

  • Ultra-Fine Particle Size (< 30 nm): Significantly increases the specific surface area and interaction with keratinocytes, ensuring superior skin penetration and biological activity compared to traditional 2-5 μm sulfur.
  • Exceptional Formulation Flexibility: The unique hydrophilic-lipophilic structural modification allows NanoActive Sulfur to be seamlessly incorporated into lotions, creams, clear gels, and water-based formulas without precipitation.
  • Aesthetic Superiority: Unlike traditional sulfur, which is chalky and difficult to suspend, NanoActive Sulfur maintains optical clarity (forming a transparent solution at typical usage levels), leaving no residue and enabling elegant cosmetic formulations.
  • High Stability & Bioavailability: The robust phospholipid-based nanocarrier prevents aggregation, protects the active payload, and ensures targeted delivery to the sebaceous glands and follicles.

5. KEY COSMETIC BENEFITS & MECHANISM OF ACTION

A. Comprehensive Sebum Regulation & Keratolysis

Excessive sebum accumulation leads to enlarged pores, follicular blockage, and inflammation. NanoActive Sulfur effectively removes surface lipids, softens the epidermis, and dissolves keratin plugs.

●Mechanism:At low concentrations, sulfur exerts a keratoplastic effect, promoting normal keratinization. At higher concentrations, it becomes keratolytic, reacting with cysteine to form cystine and hydrogen sulfide (), which safely disrupts excess keratin and clears clogged pores.

B. Targeted Antibacterial & Antifungal Action

NanoActive Sulfur acts as a potent purifying agent and helps rebalance the skin microbiome.

●Mechanism: Skin bacteria and keratinocytes convert sulfur into pentathionic acid (), a compound highly toxic to fungi and pathogenic bacteria. The keratolytic action further helps detach microorganisms from the stratum corneum.

●Microbiological Efficacy (In Vitro):

○P. aeruginosa: MIC = 1.95 μg/mL | MBC = 1000 μg/mL

○S. aureus: MIC = 125 μg/mL

○E. coli: MIC = 500 μg/mL

C. Powerful Anti-Inflammatory & Soothing Properties

Severe oxidative stress depletes intracellular Glutathione (GSH), triggering inflammatory cascades.

●Mechanism:NanoActive Sulfur supports cellular antioxidant defenses by promoting GSH synthesis.

●Efficacy:Exerts a strong, dose-dependent reduction in the expression of key pro-inflammatory cytokines. Clinical evaluations (ELISA) show that concentrations between 0.1% and 0.4% significantly downregulate the protein expression ofIL-1β,IL-6, and TNF-α.

D. Clinically Proven Acne Treatment

Inin-vivoassessments, formulations containing NanoActive Sulfur demonstrated visible improvement in acne-prone skin profiles. A 60-day application of 0.2% active showed a significant reduction in inflammatory lesions and post-acne erythema, making it an ideal candidate for long-term acne management.

6. RECOMMENDED APPLICATIONS

NanoActive Sulfur is highly versatile and is recommended for the following cosmetic product categories:

  • Acne & Blemish Control: Spot treatments, anti-acne serums, and purifying toners.
  • Sebum Control & Pore Refining: Mattifying lotions, oil-control powders, and deep-cleansing masks.
  • Brightening & Spot-Fading: Post-inflammatory hyperpigmentation (PIH) correctors.
  • Scalp Care: Anti-dandruff shampoos and scalp-soothing serums (seborrheic dermatitis support).
  • Soothing & Repair: Products targeting sensitized, inflamed, or compromised skin barriers.

7. FORMULATION GUIDANCE

  • Suggested Use Level: 0.1% – 5.0% (Depending on target efficacy: low doses for daily maintenance/anti-inflammation; higher doses for targeted spot treatments).
  • Solubility: Amphiphilic nature allows it to be easily added to either the aqueous phase or the final emulsion at room temperature or gently heated conditions.
  • Compatibility: Compatible with a wide range of cosmetic ingredients, including traditional water-based and oil-based systems. Does not cause phase separation.

8. STORAGE, HANDLING & PACKAGING

  • Storage: Store in the original, unopened container at 4°C to 25°C. Protect from direct sunlight and maintain in a dry environment.
  • Shelf Life: 12 months under specified storage conditions.
  • Packaging: Supplied in standard industrial plastic containers.

Disclaimer: The information contained in this document is provided in good faith and is based on our current knowledge and internal testing. Formulators are responsible for ensuring the final cosmetic product’s stability, safety, and regulatory compliance in their respective target markets.

PuriPharm Co. Ltd. | Advanced Active Ingredients

Puri-Xyl THE 3D HYDRATION EXPERT

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The Challenge: Dehydrated Skin

Signs of Imbalance

Environmental stress and aging disrupt the skin’s natural water balance, leading to:

  • Visual Dryness:Flaking and dullness.
  • Physical Discomfort:Tightness and roughness.
  • Structural Weakness:Compromised barrier function.

The Goal: To restore equilibrium between water reserves and water loss.

Introducing Puri-Xyl

Natural Sugar Technology:

Puri-Xylis auniquecomplex of natural sugars derived fromWheat andCorn. It represents a green chemistry approach to skin hydration.

INCI Name: Xylitylglucoside,Anhydroxylitol, Xylitol

Key Attributes: Preservative-free,Allergen-free, Non-GMO.

Green Synthesis & Structure

TheHydraconcept: 3D Hydration

Mechanism 1: Dermal Reserves

Mechanism 2: Barrier Function

Ceramide Synthesis: A healthy barrier relies on the “mortar” holding cells together. Puri-Xylsignificantly stimulates the synthesis ofCeramides 1 & 2.

The Result: This creates an “Anti-Dehydration Shield,” physically preventing water from evaporating and protecting against external aggressors.

Mechanism 3: Water Circulation

Aquaporins (AQP3): Puri-Xylupregulates Aquaporin-3, the dedicated water channels in cell membranes. This ensures active transport of water and glycerol from the dermis to the epidermis.

Tight Junctions: By reinforcing tight junctions, Puri-Xylensures that water flow is controlled and distributed evenly throughout the epidermal layers, maximizing hydration efficacy.

Clinical Evaluation Protocol

Deep Hydration Kinetics

Anti-Dehydration Shield

Skin Restructuring

Smoothing & Normalization

Puri-Xyl doesn’t just hydrate; it restructures the skin surface by normalizing the desquamation process.

+25% Improvement in desquamation (less flaking).

+30% Improvement in skin micro-relief (smoother texture).

Visual Result: Skin looks plump, healthy, and radiant.

Safety & Tolerance

Technical Profile

Versatile Applications

Puri-Xyl PRODUCT DATA SHEET

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PRODUCT DATA SHEET

Product Name: Puri-Xyl

Version: 2.0

Supplier: PuriPharm Co. Ltd.

1. PRODUCT OVERVIEW

Puri-Xyl is a moisturizing and restructuring complex derived from natural plant sugars. It is designed to harmonize the hydrous flow of the skin based on the “3D Hydration” concept, ensuring comprehensive hydration across all skin layers.

  • INCI Name: Xylitylglucoside, Anhydroxylitol, Xylitol
  • Product Category: Active Ingredient / Moisturizer
  • Origin: Plant-derived (Wheat & Corn)
  • Compliance: Preservative-free, Non-GMO, Allergen-free

2. KEY BENEFITS

Puri-Xyl optimizes the skin’s water flow, offering both immediate and long-term moisturizing benefits while reinforcing the skin barrier and improving surface texture.

  • Hydration Reservoir: Significantly boosts dermal water reserves (Glycosaminoglycans/GAGs).
  • Barrier Function: Stimulates ceramide synthesis to limit Trans-Epidermal Water Loss (TEWL).
  • Water Circulation: Optimizes the expression of Aquaporins to facilitate epidermal water flow.
  • Restructuring: Normalizes the desquamation process for smoother skin.
  • Visual Improvement: Reduces flaking/dryness and smooths micro-relief.

3. COMPOSITION

4. MECHANISM OF ACTION

Puri-Xyl acts on three levels of the skin:

1.Dermis (Reserves): Significantly increases the synthesis of Glycosaminoglycans (GAGs).

  • Chondroitin Sulfate: +183%
  • Hyaluronic Acid: +20% (Epidermis), +55% (Dermis)

2.Epidermis (Flow): Stimulates the expression ofAquaporin-3 (AQP3)to facilitate water and glycerol transport between cells; strengthens Tight Junctions.

3.Stratum Corneum (Barrier): Promotes the synthesis of Ceramides 1 and 2, reinforcing the intercellular lipid cement to create an “Anti-Dehydration Shield.”

5. EFFICACY DATA

In-Vivo Study: 25 volunteers with dry skin applied a lotion containing 3% Puri-Xyl twice daily for 30 days.

●Anti-Dehydration Shield: After 30 days, Trans-Epidermal Water Loss (TEWL) was significantly reduced by-13%.

●Hydration Kinetics:

○24 Hours:Immediate barrier reinforcement observed.

○8 Days:Visible improvement in hydration.

○30 Days:Maximum hydration effect achieved.

●Skin Restructuring:

○Desquamation Improvement:+25%(Reduced flaking)

○Skin Micro-relief:+30%(Smoother texture)

6. PHYSICAL PROPERTIES

  • Appearance: Liquid
  • Color: Colorless to pale yellow
  • Odor: Characteristic, faint
  • Solubility: Soluble in water, alcohol, and glycols
  • Shelf Life:24 months

7. FORMULATION GUIDELINES

  • Recommended Dosage:1.5% – 5.0% (Clinically tested at 3%)
  • Incorporation: Can be added at any stage of the formulation process (aqueous phase or end).
  • pH Stability:Stable over a wide pH range (pH 3.0 – 10.0).
  • Thermal Stability:Excellent; can withstand heating up to 80°C.
  • Compatibility: No known incompatibilities; compatible with high electrolyte concentrations.

8. SAFETY & TOXICOLOGY

  • Skin Tolerance:Excellent (48-hour Patch Test).
  • Ocular Tolerance:Good (HET-CAM Test).
  • Sensitization: Non-sensitizing.
  • Mutagenicity: Non-mutagenic (Ames Test).

9. APPLICATIONS

Suitable for various cosmetic formulations:

  • Face Care: Daily moisturizers, anti-aging serums, night creams.
  • Body Care: Body lotions, hand creams, shower gels (reduces surfactant irritation).
  • Hair Care:Scalp hydration treatments, shampoos, conditioners.
  • Specific Care: Products for dry/sensitive skin, after-sun care.

Disclaimer: The information contained in this data sheet is based on our current knowledge. It is the user’s responsibility to verify the suitability of the product for their specific application.

NanoActive r-RETINOATE PRODUCT DATA SHEET

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PRODUCT DATA SHEET

Product Name: NanoActive r-RETINOATE

Manufacturer: PuriPharm Co., Ltd.

Awards: 2019 Ringier Technology Innovation Award (Personal Care)

1. Product Overview

NanoActive r-RETINOATEis a next-generation, high-performance Vitamin A derivative engineered to overcome the traditional limitations of retinoid application in cosmetic science. Utilizing a proprietary 20–30 nm nano-encapsulation delivery system, this bioactive ingredient combines exceptional anti-aging efficacy with unprecedented stability and skin tolerability.

Formed by esterifying the hydroxyl group of retinol with retinoic acid, Retinyl Retinoate retains the bioactivity of both precursor molecules. It delivers up to 8x the activity of standard retinol while eliminating the characteristic irritation and photosensitivity. Crucially, its distinctive blue-light absorption profile and high photostability make it a breakthrough retinoid that is completely safe and effective for daytime application.

2. Chemical Description & Composition

  • INCI Name: Retinyl Retinoate, Ascorbic Acid (Vitamin C), Phospholipids, Caprylic/Capric Triglyceride, Glycerin, Water
  • Product Type: Nano-encapsulated Bioactive System
  • Active Concentration: Available in 1.0% or 5.0% Retinyl Retinoate specifications

3. Physical & Chemical Properties

  • Appearance: Yellow-orange viscous liquid
  • Odor: Characteristic
  • pH Value: 5.0 – 8.0
  • Solubility: Amphiphilic (compatible with both water and oil phases)
  • Photostability: Excellent (not light-sensitive; suitable for day-care formulations)

4. Platform Technology & Delivery System

PuriPharm’s advanced nano-delivery platform transforms how retinoids interact with the skin structure:

  • Targeted Follicular Absorption: The 20–30 nm particle size allows the nanocarriers to accumulate efficiently within the hair follicle pathway. This creates a deep-skin “follicular reservoir” where actives can be retained rather than merely remaining on the skin’s surface.
  • Sustained Release Kinetics: Once deposited in the appendages, the nano-emulsion structure facilitates a controlled, slow-release mechanism that extends the activity window for more than 10 days, ensuring long-lasting efficacy without overwhelming the skin barrier.
  • Unique Occlusion Effect: Nano-sized lipid carriers create a highly uniform, tight surface film, increasing residence time and local deposition of the active compound.

5. Mechanism of Action: The One-Step Advantage

Traditional retinol formulations require a slow, three-step metabolic conversion (Retinyl Esters → Retinol → Retinal → Retinoic Acid) to become biologically active.

NanoActive r-RETINOATE features a direct “One-Step Conversion.”As a direct precursor, it is highly efficient and minimizes intermediate degradation.

Biocompatibility & Cytotoxicity:

In vitro data demonstrates that Retinyl Retinoate possesses significantly lower cytotoxicity compared to standard retinol. The IC50 of retinol is 25 μM, whereas the IC50 of NanoActive r-RETINOATE is 40 μM (an approximately 60% improvement in cellular tolerability), showcasing its ability to provide intense rejuvenation without the peeling, erythema, and barrier compromise associated with traditional Vitamin A.

6. Proven Cosmetic Benefits & Efficacy Data

A. Profound Anti-Aging & UV Repair (12-Week Clinical Study)

A controlled clinical trial comparing 0.06% Retinyl Retinoate (Group A) against 0.075% Retinol (Group B) applied twice daily demonstrated superior anti-aging performance:

  • Elasticity Improvement: 90.9% of Group A subjects reported noticeable periocular elasticity improvement (vs. 81.8% in Group B).
  • Photodamage Reversal: Group A exhibited an 8.61% measurable improvement in photodamage repair (vs. 7.43% in Group B).
  • Longevity of Efficacy: NanoActive r-RETINOATE showed a significantly weaker “diminishing marginal effect,” meaning anti-wrinkle benefits continued to compound and remain highly visible even over long-term (1 year+) usage.

B. Hyaluronic Acid (HA) Expression

In vivotesting on epidermal and dermal tissues (HABP staining) confirms that NanoActive r-RETINOATE significantly upregulates endogenous mucopolysaccharide (hyaluronic acid) synthesis, heavily outperforming both standard retinol and retinoic acid.

C. Multi-Pathway Skin Enhancement

  • Structural Integrity: Inhibits UV-induced Matrix Metalloproteinases (MMP) activity, reducing the breakdown of endogenous proteins, protecting elastic fibers, and promoting collagen synthesis.
  • Tone & Clarity: Works synergistically with its Vitamin C component to inhibit tyrosinase, accelerate melanin metabolism, and reduce visible redness.
  • Texture & Blemishes: Promotes healthy keratinocyte activity, increases epidermal thickness, and functions via multiple mechanisms to clear blemishes and accelerate the repair of acne marks.

7. Formulation Guidance

NanoActive r-RETINOATE is engineered for formulation elegance and versatility:

  • Recommended Use Level: 1.0% – 5.0%
  • Optimum pH Range: 3.0 – 6.5
  • Processing: Simple to formulate. Add to the system at the final stage of manufacturing (post-emulsification, during the cooling phase) to protect the nanostructure.
  • Compatibility: Highly compatible with a wide range of cosmetic matrices. Works exceptionally well in synergy with additional Hyaluronic Acid, Vitamin C, and biocomposite polysaccharides (e.g., hydrolyzed myrtle) for accelerated wrinkle-reduction claims.

8. Recommended Applications

  • Daytime Anti-Aging Care: Day creams, lotions, and serums targeting fine lines, leveraging its unique photostability.
  • Intensive Photodamage Repair: Post-sun recovery formulations and deep wrinkle repair treatments.
  • Advanced Brightening: Radiance serums addressing hyperpigmentation and uneven skin tone (pairs perfectly with brightening regimens).
  • Acne & Barrier Repair: Clarifying formulations aimed at treating blemishes, repairing acne marks, and thickening the epidermal layer.

Disclaimer: This document is provided for informational and technical support purposes only, based on PuriPharm Co., Ltd. research and development data. Formulators are responsible for conducting full stability, compatibility, and safety evaluations of their finished cosmetic products. PuriPharm Co., Ltd. makes no warranties regarding the specific outcomes of end-user formulations.