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PuriActives® PALMITOYL METHOXYTRYPTAMINE

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Available in Pure Crystalline Powder & NanoActive® Water-Soluble Liquid Grades

1. PRODUCT IDENTIFICATION

  • Trade Name: PuriActives® PALMITOYL METHOXYTRYPTAMINE (Pure Powder Grade) / NanoActive® PALMITOYL METHOXYTRYPTAMINE (Water-Soluble Liquid Grade)
  • INCI Name (US/EU):

Pure Powder Grade: Palmitoyl Methoxytryptamine

NanoActive® Grade: Water, Glycerin, Phospholipids, Palmitoyl Methoxytryptamine, Caprylic/Capric Glyceride

  • Chemical Name (Active): N-[2-(5-methoxy-1H-indol-3-yl)ethyl]hexadecanamide
  • CAS Number (Active): 224422-91-3
  • Molecular Formula (Active): C₂₇H₄₄N₂O₂
  • Molecular Weight (Active): 428.66 g/mol
  • Chemical Structure: CH₃-(CH₂)₁₄-CO-NH-CH₂-CH₂-C₈H₄(OCH₃)NH

2. PRODUCT DESCRIPTION

PuriActives® Palmitoyl Methoxytryptamine is a high-purity, bio-mimetic lipid-alkaloid conjugate engineered to deliver profound neuro-cosmetic soothing and cellular anti-inflammatory benefits. By coupling the potent neuro-active molecule 5-methoxytryptamine (a direct analog and precursor of melatonin) with palmitic acid, this compound exhibits exceptional skin-penetration kinetics and lipid-membrane affinity.

To address the inherent solubility limitations of the pure lipophilic crystalline powder in water-based cosmetic architectures, PuriPharm offers NanoActive® Palmitoyl Methoxytryptamine. Utilizing state-of-the-art advanced nano-delivery technology, this grade encapsulates the active within a biomimetic phospholipid bilayer membrane (average particle size < 100 nm). This advanced delivery system transforms a highly lipophilic compound into a thermodynamic-stable, optically transparent, and water-dispersible active, dramatically boosting skin bioavailability and offering effortless formulation flexibility.

3. CORE MECHANISMS OF ACTION

A. Neurogenic Soothing via TRP Channel Modulation

Sensitive skin is characterized by hyper-excited sensory nerve endings. Palmitoyl Methoxytryptamine acts as a gentle, soothing modulator of neurogenic pathways. It targets transient receptor potential (TRP) channels, specifically mitigating the over-activation of TRPV1 (capsaicin receptor), which in turn suppresses sensations of burning, stinging, tightness, and itching.

B. Anti-Inflammaging & PPAR-α Activation

Similar to endogenous endocannabinoid-like molecules (such as Palmitoylethanolamide / PEA), Palmitoyl Methoxytryptamine serves as an agonist for the nuclear receptor PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha). This activation triggers downstream anti-inflammatory cascades:

  • Inhibits the release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α.
  • Suppresses mast cell degranulation, mitigating sudden skin redness and histamine-induced itchiness.

C. Melatonin Receptor Agonism & Circadian Repair

Because 5-methoxytryptamine is a direct deacetylation analog of melatonin (N-acetyl-5-methoxytryptamine), Palmitoyl Methoxytryptamine acts as a highly potent biomimetic agent for cutaneous melatonin receptors (MT1 and MT2). This direct agonism:

  • Resets and synchronizes the skin’s biological clock genes (such as CLOCK and PER1).
  • Enhances the skin’s endogenous defense against oxidative stress induced by ultraviolet (UV) radiation and blue light.
  • Accelerates nocturnal DNA repair and cell regeneration, restoring a radiant and rested complexion overnight.

D. Enhanced Bioavailability via Lipophilic Vectoring & Nano-Carrier Delivery

  • Pure Powder: Conjugation with palmitic acid increases the partition coefficient (log P ≈ 7.15), allowing the active to integrate seamlessly into the intercellular lipid matrix of the stratum corneum.
  • NanoActive® Liquid: The phospholipid membrane of the nano-carriers fuses directly with the lipid bilayers of the stratum corneum. This bypasses the rate-limiting barrier of intercellular lipid transport, creating a “depot effect” in the viable epidermis and accelerating cellular uptake of the active molecule.

4. TECHNICAL SPECIFICATIONS

[Grade A] PuriActives® PALMITOYL METHOXYTRYPTAMINE (Pure Powder)

[Grade B] NanoActive® PALMITOYL METHOXYTRYPTAMINE (Water-Soluble Liquid)

Microbiological Specifications (Both Grades)

  • Total Aerobic Plate Count: ≤ 100 CFU/g
  • Yeasts and Molds: ≤ 10 CFU/g
  • Pathogens (E. coli, S. aureus, P. aeruginosa): Negative/g

5. COSMETIC BENEFITS & CLINICAL CLAIMS

  • Instant Neuro-Soothing: Rapidly reduces sensory discomfort, itching, and neuro-sensitivity.
  • Anti-Redness & Erythema Control: Dampens micro-vascular reactivity and controls flushing in rosacea-prone skin.
  • Skin Barrier Recovery: Accelerates epidermal barrier repair and decreases trans-epidermal water loss (TEWL).
  • Intense Inflammaging Defense: Protects structural proteins (collagen and elastin) from enzymatic degradation caused by chronic low-grade inflammation.
  • Chronobiological Renewal: Aids in resetting skin repair rhythms, restoring a radiant and rested complexion overnight.

6. FORMULATION & PROCESSING GUIDELINES (PURE POWDER)

A. Recommended Usage Levels

  • Daily Soothing & Maintenance Creams: 0.05% – 0.2%
  • Intensive SOS / Post-Procedure Care: 0.2% – 0.5%

B. Solubility & Incorporation

  • Oil Phase: Soluble in hot cosmetic esters and lipids (e.g., Caprylic/Capric Triglyceride, Squalane, C12-15 Alkyl Benzoate) at 75°C – 80°C.
  • Water Phase: Insoluble in water.

C. Processing Temperature

● Stable at temperatures up to 85°C. It is recommended to dissolve the active in the oil phase before emulsification.

7. FORMULATION & PROCESSING GUIDELINES (NANOACTIVE® LIQUID)

A. Recommended Usage Levels

  • Daily Soothing Serums & Toners: 1.0% – 4.0% (Equivalent to 0.05% – 0.2% pure active)
  • High-Concentration Clinical Soothing Ampoules: 4.0% – 10.0% (Equivalent to 0.2% – 0.5% pure active)

B. Solubility & Incorporation

  • Water Phase: 100% dispersible in water. It yields an elegant, optically transparent solution, ideal for clear gel, serum, toner, and essence formulations.
  • Incorporation: Highly recommended to add to the water phase or post-emulsification phase during the cooling stage at temperatures below 40°C.

C. Processing Guidelines & Shear Sensitivity

● Avoid exposing NanoActive® grade to high-shear homogenization equipment (e.g., rotor-stator homogenizers) for prolonged periods, as extreme shear can disrupt the lipid vesicle bilayers. Use paddle stirring or gentle marine propellers to disperse.

D. pH Stability (NanoActive®)

● Optimum stability is observed within a pH range of 4.5 – 6.5.

8. STORAGE, SHELF LIFE & REGULATORY

● Storage Conditions: Store in the original, tightly sealed container.

  • Pure Powder: Keep in a cool, dry, and well-ventilated area, preferably refrigerated at 2°C – 8°C for long-term storage.
  • NanoActive® Liquid: Do not freeze. Store at 4°C – 25°C, protected from direct sunlight and heat.

● Shelf Life: 24 months from the date of manufacture when stored under prescribed conditions.

● Regulatory Compliance: Approved for use in cosmetics worldwide (including EU, USA, and China IECIC listing). Vegan-compliant, cruelty-free, and non-GMO.

Disclaimer: The information contained in this document is provided in good faith and is based on our current technical knowledge. Formulation results may vary depending on other raw materials and processing equipment used. It is the formulator’s responsibility to conduct final product safety and efficacy tests.

PuriActives® PALMITOYL TRYPTAMINE

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Available in Pure Crystalline Powder & NanoActive® Water-Soluble Liquid Grades

1. PRODUCT IDENTIFICATION

  • Trade Name: PuriActives® PALMITOYL TRYPTAMINE (Pure Powder Grade) / NanoActive® PALMITOYL TRYPTAMINE (Water-Soluble Liquid Grade)

INCI Name (US/EU):

  • Pure Powder Grade: Palmitoyl Tryptamine
  • NanoActive® Grade: Water, Glycerin, Phospholipids, Palmitoyl Tryptamine, Caprylic/Capric Triglyceride
  • Chemical Name (Active): N-[2-(1H-indol-3-yl)ethyl]hexadecanamide
  • CAS Number (Active): 21469-15-8
  • Molecular Formula (Active): C₂₆H₄₂N₂O
  • Molecular Weight (Active): 398.63 g/mol
  • Chemical Structure: CH₃-(CH₂)₁₄-CO-NH-CH₂-CH₂-C₈H₅NH

2. PRODUCT DESCRIPTION

PuriActives® Palmitoyl Tryptamine is a high-purity, bio-mimetic lipid-alkaloid conjugate engineered to deliver profound neuro-cosmetic soothing and cellular anti-inflammatory benefits. By coupling the potent neuro-active molecule tryptamine with palmitic acid, this compound exhibits exceptional skin-penetration kinetics and lipid-membrane affinity.

To address the inherent solubility limitations of the pure lipophilic crystalline powder in water-based cosmetic architectures, PuriPharm offers NanoActive® Palmitoyl Tryptamine. Utilizing state-of-the-art advanced nano-delivery technology, this grade encapsulates the active within a biomimetic phospholipid bilayer membrane (average particle size < 100 nm). This advanced delivery system transforms a highly lipophilic compound into a thermodynamic-stable, optically transparent, and water-dispersible active, dramatically boosting skin bioavailability and offering effortless formulation flexibility.

3. CORE MECHANISMS OF ACTION

A. Neurogenic Soothing via TRP Channel Modulation

Sensitive skin is characterized by hyper-excited sensory nerve endings. Palmitoyl Tryptamine acts as a gentle, soothing modulator of neurogenic pathways. It targets transient receptor potential (TRP) channels, specifically mitigating the over-activation of TRPV1 (capsaicin receptor), which in turn suppresses sensations of burning, stinging, tightness, and itching.

B. Anti-Inflammaging & PPAR-α Activation

Similar to endogenous endocannabinoid-like molecules (such as Palmitoylethanolamide / PEA), Palmitoyl Tryptamine serves as an agonist for the nuclear receptor PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha). This activation triggers downstream anti-inflammatory cascades:

  • Inhibits the release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α.
  • Suppresses mast cell degranulation, mitigating sudden skin redness and histamine-induced itchiness.

C. Melatonin Pathway Synergy & Circadian Repair

Because tryptamine is an biochemical precursor in the melatonin and serotonin synthesis pathways, topical application of Palmitoyl Tryptamine supports the skin’s nocturnal repair mechanisms. It enhances the skin’s endogenous defense against oxidative stress induced by ultraviolet (UV) radiation and blue light, helping to maintain cellular homeostasis during sleep.

D. Enhanced Bioavailability via Lipophilic Vectoring & Nano-Carrier Delivery

  • Pure Powder: Conjugation with palmitic acid increases the partition coefficient (log P ≈ 6.83), allowing the active to integrate seamlessly into the intercellular lipid matrix of the stratum corneum.
  • NanoActive® Liquid: The phospholipid membrane of the nano-carriers fuses directly with the lipid bilayers of the stratum corneum. This bypasses the rate-limiting barrier of intercellular lipid transport, creating a “depot effect” in the viable epidermis and accelerating cellular uptake of the active molecule.

4. TECHNICAL SPECIFICATIONS

[Grade A] PuriActives® PALMITOYL TRYPTAMINE (Pure Powder)

[Grade B] NanoActive® PALMITOYL TRYPTAMINE (Water-Soluble Liquid)

Microbiological Specifications (Both Grades)

  • Total Aerobic Plate Count: ≤ 100 CFU/g
  • Yeasts and Molds: ≤ 10 CFU/g
  • Pathogens (E. coli, S. aureus, P. aeruginosa): Negative/g

5. COSMETIC BENEFITS & CLINICAL CLAIMS

  • Instant Neuro-Soothing: Rapidly reduces sensory discomfort, itching, and neuro-sensitivity.
  • Anti-Redness & Erythema Control: Dampens micro-vascular reactivity and controls flushing in rosacea-prone skin.
  • Skin Barrier Recovery: Accelerates epidermal barrier repair and decreases trans-epidermal water loss (TEWL).
  • Intense Inflammaging Defense: Protects structural proteins (collagen and elastin) from enzymatic degradation caused by chronic low-grade inflammation.
  • Chronobiological Renewal: Aids in resetting skin repair rhythms, restoring a radiant and rested complexion overnight.

6. FORMULATION & PROCESSING GUIDELINES (PURE POWDER)

A. Recommended Usage Levels

  • Daily Soothing & Maintenance Creams: 0.05% – 0.2%
  • Intensive SOS / Post-Procedure Care: 0.2% – 0.5%

B. Solubility & Incorporation

  • Oil Phase: Soluble in hot cosmetic esters and lipids (e.g., Caprylic/Capric Triglyceride, Squalane, C12-15 Alkyl Benzoate) at 75°C – 80°C.
  • Water Phase: Insoluble in water.

C. Processing Temperature

●Stable at temperatures up to 85°C. It is recommended to dissolve the active in the oil phase before emulsification.

7. FORMULATION & PROCESSING GUIDELINES (NANOACTIVE® LIQUID)

A. Recommended Usage Levels

  • Daily Soothing Serums & Toners: 1.0% – 4.0% (Equivalent to 0.05% – 0.2% pure active)
  • High-Concentration Clinical Soothing Ampoules: 4.0% – 10.0% (Equivalent to 0.2% – 0.5% pure active)

B. Solubility & Incorporation

  • Water Phase: 100% dispersible in water. It yields an elegant, optically transparent solution, ideal for clear gel, serum, toner, and essence formulations.
  • Incorporation: Highly recommended to add to the water phase or post-emulsification phase during the cooling stage at temperatures below 40°C.

C. Processing Guidelines & Shear Sensitivity

  • Avoid exposing NanoActive® grade to high-shear homogenization equipment (e.g., rotor-stator homogenizers) for prolonged periods, as extreme shear can disrupt the lipid vesicle bilayers. Use paddle stirring or gentle marine propellers to disperse.

D. pH Stability (NanoActive®)

  • Optimum stability is observed within a pH range of 4.5 – 6.5.

8. STORAGE, SHELF LIFE & REGULATORY

  • Storage Conditions: Store in the original, tightly sealed container.
  • Pure Powder: Keep in a cool, dry, and well-ventilated area, preferably refrigerated at 2°C – 8°C for long-term storage.
  • NanoActive® Liquid: Do not freeze. Store at 4°C – 25°C, protected from direct sunlight and heat.
  • Shelf Life: 24 months from the date of manufacture when stored under prescribed conditions.
  • Regulatory Compliance: Approved for use in cosmetics worldwide (including EU, USA, and China IECIC listing). Vegan-compliant, cruelty-free, and non-GMO.

Disclaimer: The information contained in this document is provided in good faith and is based on our current technical knowledge. Formulation results may vary depending on other raw materials and processing equipment used. It is the formulator’s responsibility to conduct final product safety and efficacy tests.

PuriActives® Sodium Algin Sulfate The Marine-Derived GAGs Biomimetic for Ultimate Cellular Regeneration

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Company: PuriPharm Co. Ltd.

Product Category: Active Ingredient / Anti-Aging & Skin Barrier Repair

Format: Technical & Marketing Brochure

1. Executive Summary

PuriActives® Sodium Algin Sulfate is an advanced, highly purified sulfated polysaccharide derived from premium marine brown algae. Engineered through precise biomimetic biotechnology, it acts as a structural and functional analogue to endogenous Glycosaminoglycans (GAGs), specifically Heparan Sulfate.

By mimicking the extracellular matrix’s (ECM) natural biological environment, Sodium Algin Sulfate plays a crucial role in stabilizing growth factors, reducing chronic inflammation (“inflammaging”), and accelerating deep skin tissue repair. It is the ultimate marine-biotech solution for premium anti-aging, soothing, and post-procedure recovery formulations.

2. The Scientific Rationale: A Master of the Extracellular Matrix (ECM)

As skin ages, the natural pool of Heparan Sulfate in the ECM depletes, leading to structural collapse, impaired cellular communication, and accelerated wrinkling.

PuriActives® Sodium Algin Sulfate features a precisely controlled Degree of Sulfation (DS) that closely mimics human GAGs.

  • Growth Factor Stabilization: Its negatively charged sulfated topology allows it to bind specifically to endogenous growth factors (e.g., FGF, EGF, TGF-β), protecting them from proteolytic degradation and amplifying their signaling pathways for collagen synthesis.
  • MMP Inhibition: It competitively binds to and inhibits Matrix Metalloproteinases (MMPs), particularly Hyaluronidase and Elastase, preserving the skin’s natural hyaluronic acid and elastin reservoirs.

3. Core Clinical Efficacies

I. Profound Anti-Aging & Wrinkle Reduction

By acting as a biological reservoir for growth factors, Sodium Algin Sulfate stimulates fibroblast proliferation and upregulates the synthesis of Collagen I and III. It restores the dermal-epidermal junction (DEJ) architecture, resulting in visibly firmer skin and a reduction in fine lines.

II. Rapid Barrier Repair & Soothing

Exhibiting exceptional anti-inflammatory properties, it actively downregulates pro-inflammatory cytokines (such as IL-1α and TNF-α). It accelerates epidermal re-epithelialization, making it highly effective for sensitive skin, rosacea, and post-aesthetic procedure care (e.g., post-laser, post-peel).

III. Deep, Sustained Hydration

Unlike standard humectants that merely hold water on the surface, its high molecular weight and dense charge network create a breathable, 3D bio-polymeric film. This shields against trans-epidermal water loss (TEWL) while actively modulating cellular hydration channels from within.

4. Technical Specifications & Formulation Guidelines

  • INCI Name: Sodium Algin Sulfate (and) Water (Aqua)
  • Appearance: Clear to slightly yellowish, viscous liquid.
  • Odor: Characteristic (mild marine origin).
  • Solubility: 100% soluble in water. Insoluble in oils and high concentrations of ethanol.
  • pH Value (at 20°C): 5.0 – 7.5
  • Recommended Usage Level: 1.0% – 5.0%

Formulation Advantages (The PuriPharm Edge):

  • High Compatibility: Compatible with a wide range of cosmetic chassis, including clear serums, O/W emulsions, and hydrogels.
  • Stability: Highly stable against thermal stress (up to 80°C) and light. Can be added to the aqueous phase before homogenization or post-added during the cooling phase below 40°C.
  • Synergistic Potential: Pairs perfectly with peptides, ceramides, and PuriPharm’s NanoActive® encapsulates (like NanoActive® Phloretin) for comprehensive anti-aging and barrier-repair protocols.

5. Application Horizons

  • Intensive Anti-Aging Serums: To restructure the dermal matrix and enhance firmness.
  • Dermatological Soothing Creams: For hypersensitive, reactive, or compromised skin.
  • Post-Procedure Care: Accelerating recovery after laser treatments, micro-needling, or chemical peels.
  • Scalp Care Therapies: Reducing scalp inflammation and maintaining follicular ECM health.

PuriPharm Co. Ltd.

Active Science. Advanced Delivery. Real Impact.

For technical dossiers, material safety data sheets (MSDS), or formulation assistance, please contact our R&D support team.

Email: Service@puripharm.com | Web: www.PuriActives.com

NanoActive PHLORETIN

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PURIPHARM: MOLECULAR EXCELLENCE

Bridging Science & Formulations

We empower global personal care brands through two core pillars of innovation, ensuring biological efficacy meets precise spatial delivery.

NANOACTIVE® ARCHITECTURE

PHLORETIN: THE APPLE EXTRACT

THE SOLUBILITY CHALLENGE

NANOACTIVE® PHLORETIN LIQUID

PRODUCT SPECIFICATIONS

ANTIOXIDANT EFFICACY

ANTI-INFLAMMATORY ACTION

LUMINOSITY & CLARITY

Biological Shield

Beyond traditional UV filters, NanoActive Phloretin prevents cellular damage at the DNA level:

Prevents Thymine Dimer formation.

Reduces p53 protein expression (Stress marker).

Preserves Langerhans Cells for immune defense.

FORMULATOR’S ADVANTAGE

PuriActives® Ursolene™ BZ (Benzyl Ursolate)

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Precision-Engineered Triterpenoid: The Cornerstone of Deep Dermal Rejuvenation & Structural Reconstruction

1. Product Overview

While natural pentacyclic triterpenes (like Ursolic Acid) are renowned for their exceptional biological activities, their cosmetic application has historically been bottlenecked by extremely poor lipophilicity, low skin penetration, and formulation instability (propensity to crystallize).

Enter PuriActives® Ursolene™ BZ (INCI: Benzyl Ursolate). By introducing a benzyl group to the ursolic acid backbone, we have fundamentally shifted the molecule’s partition coefficient ( log P). This precise structural modification transforms a traditional botanical extract into a highly bioavailable, oil-soluble powerhouse. It precisely targets the Extracellular Matrix (ECM) architecture, offering a definitive solution for intrinsic/extrinsic aging, loss of elasticity, and compromised skin barriers.

The Core Edge: The perfect synergy of a naturally derived core and rational structural design, bridging the gap between pharmaceutical-grade precision and cosmetic applicability.

2. Key Biological Pathways & Mechanism of Action

PuriActives® Ursolene™ BZ operates through a multi-target mechanism, mitigating tissue senescence at the cellular level:

MMP Modulation & ECM Protection: Acts as a potent competitive inhibitor of Matrix Metalloproteinases (specifically MMP-1 and MMP-9), halting the enzymatic degradation cascade of collagen and elastin networks.

Fibroblast Activation via TGF-β Pathway: Stimulates the transforming growth factor-beta (TGF-β) signaling pathway, upregulating COL1A1 and COL3A1 gene expression to drive the de novo synthesis of structural proteins.

Inflammaging Mitigation: Suppresses the cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) pathways, interrupting the chronic micro-inflammatory cascades that accelerate tissue aging.

Epidermal Lipid Biosynthesis: Upregulates serine palmitoyltransferase (SPT) activity, driving endogenous ceramide production to fortify the stratum corneum barrier.

3. Proven Efficacy (In Vitro & In Vivo Highlights)

Our rigorous efficacy testing matrix demonstrates statistically significant improvements compared to vehicle and unmodified free ursolic acid controls.

In Vitro: Dermal Architecture Support

  • + 42% Increase in Pro-collagen I synthesis (Primary human fibroblasts, at 10μM, ).
  • – 65% Reduction in UV-induced elastase activity, effectively preserving skin recoil capacity.

In Vivo Clinical Study: Facial Micro-Topography (28-Day Study)

A double-blind, placebo-controlled clinical study on 30 female volunteers (aged 45-65), applying a 0.2% PuriActives® Ursolene™ BZ cream twice daily.

● Wrinkle Depth (Ra): Significant reduction of 21.4% in the periocular region.

● Skin Density: Ultrasound imaging revealed a +15% increase in dermal echogenicity, indicating structural redensification of the dermis.

4. Formulation & Technical Guidelines

PuriActives® Ursolene™ BZ is engineered for the ultimate formulator experience. Its esterified structure completely circumvents the notorious crystallization issues of free ursolic acid, enabling the creation of highly stable, cosmetically elegant emulsions.

● INCI Name: Benzyl Ursolate

● Appearance: White to off-white crystalline powder

● Solubility: Soluble in cosmetic esters (e.g., Caprylic/Capric Triglyceride, Squalane), ethanol, and glycols. Insoluble in water.

● Recommended Usage Level: 0.05% – 0.30%

● Formulation Integration: Add to the heated oil phase ( 70~80℃ ) and stir until fully dissolved before emulsification.

● Optimal pH Range: 4.5 – 6.5

5. Sustainability & Purity

PuriActives® Ursolene™ BZ is derived from upcycled apple pomace and rosemary extract precursors, synthesized via a highly efficient, atom-economical esterification process. We guarantee an ultra-high purity active (HPLC ＞ 95%) while minimizing our environmental footprint.

Recommended Applications:

● Premium Anti-Aging Night Creams

● Intensive Barrier Repair Serums

● Dermo-cosmetics (Post-Procedure Care)

● Sun Recovery & “Anti-Inflammaging” Formulations

NanoActive DHM

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NanoActive DHM Epigenetic Youth Restorer & DNA Methylation Inhibitor

1. PRODUCT IDENTIFICATION

  • Product Name: NanoActive DHM
  • Trade Name: NanoActive DHM by PuriPharm
  • INCI Name: Water, Glycerin, Caprylic/Capric Triglyceride, Ampelopsis Grossedentata Extract, Phospholipids, Tocopheryl Acetate.
  • Botanical Source of Active: Ampelopsis grossedentata(Vine Tea)
  • Active Content: 9.5% – 10.5% (Ampelopsis Grossedentata Extract)

2. PRODUCT DESCRIPTION

NanoActive DHM represents a paradigm shift in epigenetic anti-aging. Developed by PuriPharm Co. Ltd., it is the industry’s first cosmetically viable DNA methylation inhibitor. Utilizing advanced nanoliposomal technology, highly purified Dihydromyricetin (DHM) is encapsulated in a biomimetic phospholipid bilayer. This sophisticated delivery system overcomes the inherent instability and poor skin penetration of DHM, allowing for targeted delivery to the deep epidermis and dermis, fundamentally reversing cellular aging at the genetic transcription level.

3. MECHANISM OF ACTION

Environmental stressors (UV, pollution) and intrinsic aging lead to hypermethylation of DNA, which functionally “silences” essential youth and structural genes.

  • Epigenetic Reversal: NanoActive DHM acts as a potent DNA methylation inhibitor, effectively removing age-induced methyl tags.
  • Gene Reactivation: By modulating over 10,000 methylation sites, it reactivates silenced genes associated with the Extracellular Matrix (ECM), signal transduction, and autophagy.
  • Targeted Delivery: The 50-150 nm liposomal spheres ensure enhanced transdermal absorption and a sustained-release profile, maximizing biological availability and minimizing potential irritation.

4. TECHNICAL SPECIFICATIONS

5. EFFICACY & CLINICAL DATA SUMMARY

  • Transcriptomic Upregulation: Significantly upregulates key structural genes including COL6A1 (Collagen Type VI), ITGB6, ITGA5, and VCL, restoring cellular anchorage and tissue firmness.
  • 3D Skin Equivalent Model: In a 6-week in vitrostudy utilizing 20µM DHM on mature 3D skin models, NanoActive DHM effectively reversed epidermal thinning. Epidermal thickness increased from 30µm (untreated mature control) to ~50µm, closely mirroring the baseline of young skin models (60µm). Statistical significance achieved (p = 0.00064).

6. FORMULATION GUIDELINES

NanoActive DHM is designed for ease of use in premium cosmetic formulations.

  • Recommended Usage Level: 1.0% – 5.0%
  • Incorporation Phase: Add to the aqueous phase or during the cooling phase (below 45°C) for emulsions to maintain liposomal integrity.
  • pH Compatibility: Stable within a final formulation pH range of 4.5 – 7.5.
  • Incompatibilities: Avoid high concentrations of strong ionic surfactants or extreme ethanol levels (>20%) which may disrupt the lipid bilayer.
  • Processability: Do not subject to intense, prolonged shear force (homogenization > 3000 rpm for extended periods) after incorporation.

7. TARGET APPLICATIONS

  • Premium Anti-Aging Skincare: Serums, night creams, and eye treatments targeting chronological aging and photoaging.
  • Medical Aesthetics Post-Care: Restorative formulations designed to prolong the effects of clinical treatments by maintaining epigenetic cellular health.
  • Preventative Aging: Solutions targeting millennials/Gen-Z exposed to urban pollution, stress, and lifestyle-induced epigenetic damage.

8. STORAGE & SHELF LIFE

  • Storage Conditions: Store in a cool, dry place away from direct sunlight. Recommended storage temperature: 4°C – 25°C. Do not freeze. Keep containers tightly sealed when not in use.
  • Shelf Life: 24 months from the date of manufacture under optimal storage conditions.

Disclaimer: The information provided herein is based on our current knowledge and rigorous scientific testing. It is intended for informational purposes for cosmetic professionals and formulators. It is the responsibility of the formulator to ensure the stability, safety, and regulatory compliance of the final consumer product.

PuriPharm Co. Ltd.Pioneering Epigenetic Skincare SolutionsWebsite: www.puriactives.com | Email: service@puripharm.com

NanoActive DHM

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Scientific Breakthrough: Epigenetic Anti-AgingDeveloped byPuriPharmCo. Ltd.

1. Epigenetics and Skin Aging

What is Epigenetics?

Epigenetics is the science studying how lifestyle and environmental factors influence gene expression.

This process occurs without changing the underlying DNA sequence.

Instead, it alters gene activity by turning genes “on” or “off” based on external stimuli.

It provides a profound new target for anti-aging interventions by addressing the root causes of cellular decline.

The Identical Twins Study

Primary Drivers of Skin Aging

The Process of DNA Methylation

Lifestyle and environmental factors influence gene expression primarily through DNA methylation.

Methyl groups (epigenetic factors) attach to the DNA molecule.

These methylation marks can activate or, more commonly in aging, improperly repress or “silence” specific genes.

This makes the DNA inaccessible to the machinery that keeps cells youthful and functional.

Hypermethylation and Aging

2. The DHM Breakthrough

Introducing Dihydromyricetin: The world’s first cosmetic DNA methylation inhibitor.

A Global Innovation

Dihydromyricetin (DHM)：

NanoActive DHM features Dihydromyricetin, globally recognized as the first cosmetic ingredient scientifically proven to inhibit DNA methylation. This represents a paradigm shift, leading a completely new direction in epigenetic anti-aging interventions.

Mechanism of Action

Inhibit Methylation: DHM acts directly at the genetic level to regulate and inhibit the excessive DNA methylation patterns that accumulate over time.

Reactivate Youth Genes: By removing these inhibitory methyl tags, DHM successfully reactivates silenced youth genes.

Restore Vitality: This fundamentally delays cellular aging by returning skin cells to their peak functional state, rather than just treating surface symptoms.

Natural Plant Source

NanoActive DHM is extracted exclusively from Ampelopsis Grossedentata, commonly known as Vine Tea.

It belongs to the Vitaceae family, Ampelopsis genus.

This specific plant is exceptionally rich in naturally occurring Dihydromyricetin.

It provides a clean, sustainable, and highly potent botanical source for epigenetic anti-aging formulations.

Cultivation & Extraction

3. Advanced Nanoliposome Technology

Nanoliposome Principles

Definition: Nanoliposomes are microscopic vesicles composed of phospholipid bilayers that perfectly mimic the human cell membrane structure.

Average Size: Ranging from 10 to 50 nm, they are perfectly sized to penetrate the skin barrier effectively.

Encapsulation: They possess a high drug entrapment efficiency, capable of securely encapsulating both hydrophobic and hydrophilic active ingredients like DHM.

Technology Advantages

The Dual Breakthrough

4. Clinical Efficacy and Validation

DNA Methylation Impact

Reversing the Clock

Under experimental conditions (20µM DHM over 6 weeks on a skin equivalent model), DHM treatment significantly affected over 10,000 methylation sites. It successfully induced a young epidermal DNA methylation pattern, restoring youthful epigenetic characteristics.

Epidermal Structure Improvement

Reactivation of Youth Genes

5. Market Application & Value

Competitive Advantage

Target Market & Applications

LipoEcdysone™ PRO: The Biomimetic Phytosteroid Revolution

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Advanced Liposomal Hydroxyecdysone for High-Performance Cosmetics & Nutraceuticals

1. Product Concept: Unlocking Nature’s Blueprint

Hydroxyecdysone (20-HE) is a highly potent phytosteroid naturally found in select adaptogenic plants. Renowned for its extraordinary ability to stimulate cellular vitality and protein synthesis, its traditional application has been limited by poor solubility and low bioavailability.

Enter LipoEcdysone™ PRO. By utilizing cutting-edge, pharmaceutical-grade liposomal encapsulation technology, we have engineered a highly stable, bioavailable delivery system. Our biomimetic phospholipid vesicles seamlessly integrate with human cell membranes, ensuring deep tissue penetration and targeted active release—bridging the gap between natural potential and ultimate clinical efficacy.

2. The Liposomal Advantage: Science Meets Delivery

Standard Hydroxyecdysone struggles to cross the stratum corneum in skin or survive enzymatic degradation in the gut. Our proprietary liposomal matrix solves this:

  • Biomimetic Penetration: Phospholipid bilayers mimic cellular structures, facilitating endocytosis and direct intracellular delivery.
  • Enhanced Stability: Protects the active phytosteroid from oxidation, pH variations, and metabolic breakdown.
  • Sustained Release: Controlled time-release mechanism prevents active degradation and prolongs biological efficacy.

3. Cosmetic Applications (Personal Care)

Architecting Skin Density & Resilience from Within

In cosmetic formulations, LipoEcdysone™ PRO acts as a powerful anti-aging and skin-restoring agent. It stimulates the skin’s natural regenerative pathways without the side effects associated with synthetic retinoids.

Key Mechanisms & Benefits:

  • Epidermal Reinforcement: Accelerates keratinocyte differentiation, fortifying the skin barrier and increasing epidermal thickness.
  • Dermal Matrix Redensification: Up-regulates the synthesis of Collagen I and III, effectively improving skin elasticity and smoothing deep wrinkles.
  • Micro-Wound Healing: Ideal for post-procedure or compromised skin, promoting rapid tissue repair through enhanced cellular crosstalk.

Recommended Applications: Anti-aging serums, skin-barrier repair creams, post-treatment recovery lotions, and firming body care.

4. Nutraceutical Applications (Functional Foods & Supplements)

The Ultimate Natural Anabolic & Metabolic Adaptogen

For the sports nutrition and longevity markets, LipoEcdysone™ PRO delivers unparalleled systemic benefits. By significantly increasing oral bioavailability, lower dosages achieve superior physiological results.

Key Mechanisms & Benefits:

  • Muscle Protein Synthesis (MPS): Activates the PI3K/Akt signaling pathway, promoting lean muscle mass accretion and accelerating recovery post-exercise.
  • Metabolic Homeostasis: Acts as a powerful adaptogen, supporting glucose metabolism and mitigating the physical markers of stress.
  • Joint & Cartilage Support: Exhibits anti-inflammatory properties, preserving extracellular matrix integrity in joints for aging populations and athletes.

Recommended Applications: Sports recovery shots, longevity capsules, adaptogenic functional beverages, and joint-health gummies.

5. Technical Specifications & Formulation Guidelines

  • INCI Name: Phospholipids (and) PHYTOECDYSTEROIDS.
  • Appearance: Translucent to slightly opalescent fluid.
  • Particle Size (D50): < 150 nm (Ensuring optimal cellular uptake).
  • Solubility: Dispersible in water; compatible with both hydrophilic and lipophilic systems.
  • Recommended Use Level: * Cosmetics: 1.0% – 5.0% (Add during the cooling phase, below 40°C).

Nutraceuticals: Please refer to local regulatory guidelines for dietary supplement dosing.

  • Preservative System:Self-preserving / Preservative-free options available.
  • Sustainability: Ethically sourced botanical extracts, solvent-free liposomal extrusion process, 100% vegan and cruelty-free.

Disclaimer: The information provided is for B2B educational purposes. Finished product claims must be evaluated by the respective legal and regulatory bodies of the target markets.