Tag Archives: Nano-liposomal haematococcus astaxanthin. Anti-oxidation

PuriActives®SupraSalix A Supramolecular Salicylic Acid System for Clearer,Calmer and Better-Balanced Skin

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THE NEW STANDARD IN CLARIFYING CARE

THE SALICYLIC ACID PARADOX

BEYOND CONVENTIONAL FREE SALICYLIC ACID

INTRODUCING PURIACTIVES® SUPRASALIX

WHAT “SUPRAMOLECULAR” MEANS

FOUR COMPONENTS, ONE INTEGRATED SYSTEM

SALICYLIC ACID: PRECISION CLARIFICATION

ZINC GLYCINATE: ANTIOXIDANT & COMFORT

XYLOGLUCAN: A SOFT PROTECTIVE INTERFACE

ALPHA-GLUCAN OLIGOSACCHARIDE: MICROBIOME CARE

THE 4D SUPRASALIX PLATFORM

A MULTI-LEVEL SKIN-BALANCE STRATEGY

DESIGNED FOR BETTER FORMULATION FREEDOM

EVIDENCE ARCHITECTURE

PUBLISHED SALICYLIC ACID EVIDENCE: CONTEXT

PUBLISHED ZINC-GLYCINE EVIDENCE

FROM FACIAL CLARITY TO SCALP BALANCE

FORMULATION FORMATS

PRODUCT-SPECIFIC VALIDATION ROADMAP

RESPONSIBLE CLAIMS & REGULATORY AWARENESS

WHY PURIACTIVES® SUPRASALIX

NanoActive®Curcumin

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Market Background

Why Curcumin?

Conventional Curcumin Challenges

NanoActive® Nano-Delivery Platform

Product Concept

Core Benefits

Mechanism 1: Antioxidant Defense

Mechanism 2: Soothing & Skin Comfort

Mechanism 3: Photoaging Care

Mechanism 4: Skin Radiance & Even Tone

Nano-Encapsulation Advantages

Formulation Applications

Formulation Guidelines

Suggested Product Claims

Comparison with Common Antioxidants

Target Formulation Concepts

The PuriPharm Advantage

Safety & Compliance

Marketing Copy Suggestions

Scientific References

Product Data Sheet: NanoActive® Bakuchiol

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1. Product Description

NanoActive® Bakuchiol is a premium, biomimetic active ingredient concept featuring highly concentrated Bakuchiol encapsulated within a proprietary sub-micron lipid nanocarrier system. Derived from the seeds of Psoralea corylifolia, this retinol-like botanical active is engineered for enhanced stability, superior aqueous dispersion, and high tolerability in modern anti-aging, sensitive-skin, and blemish-care applications.

2. INCI Name & Composition

  • INCI Name: Water (Aqua), Glycerin, Bakuchiol, Phospholipids, Caprylic/Capric Triglyceride.
  • Source: 100% Plant-derived active (Bakuchiol).
  • Solubility: Highly miscible in water-based phases; easily incorporated into aqueous serums, hydrogels, and O/W emulsions.

3. Chemical-Physical & Microbiological Specifications

Designed to meet stringent global quality standards, ensuring optimal safety and formulation elegance.

4. Key Technical Advantages

  • Retinol-like Efficacy: Acts on the same biological pathways as retinol (e.g., retinoic acid receptor signaling) without the associated irritation or light sensitivity.
  • Aqueous Transparency: The glycerin-water nanocarrier base allows the formulation of crystal-clear serums without the need for harsh solubilizers.
  • Advanced Nano-Delivery: NanoActive® encapsulation ensures controlled, sustained delivery of the 10% active payload deep into the epidermal layers.
  • Skin Barrier Support: Integrated phospholipid bilayer mimics skin lipids, reinforcing the barrier function while delivering the active.

5. Clinical Evidence Highlights

  • Anti-Aging: Supports significant reduction in the appearance of fine lines and wrinkles.
  • Firmness & Elasticity: Promotes the appearance of a firmer skin texture by supporting collagen I, III, and IV expression.
  • Soothing & Inflammation: Effectively supports the reduction of visible redness and inflammation in sensitive and acne-prone skin.
  • Pigmentation: Helps achieve a more uniform skin tone and brightness through the modulation of pigment-related pathways.

6. Formulation Guidelines

  • Recommended Use Level: 1.0% – 5.0% (delivering 0.1% – 0.5% pure Bakuchiol to the final product).
  • Processing:
  • Phase: Add into the water phase or during the final cool-down phase (below 45°C) to maintain the integrity of the nanocarrier system.
  • pH Stability: Optimal range 4.5 – 7.0.
  • Antioxidant Protection: Since the delivery system relies on an aqueous/glycerin base, adding complementary antioxidants (e.g., Vitamin E, stabilized Vitamin C) to the final formulation is highly recommended to protect the active from long-term oxidation.
  • Chelating Agents: EDTA or naturally derived chelators (e.g., Sodium Phytate) are recommended to ensure formula stability.

7. Safety & Regulatory

  • Safety Profile: High tolerability demonstrated in clinical use; suitable for sensitive skin. Non-phototoxic.
  • Claims: Supports acne-prone skin care, helps improve the appearance of blemish-prone skin, promotes clearer-looking skin, anti-aging, skin soothing.
  • Storage: Store in a cool, dry place, protected from direct light and heat. Keep container tightly closed.

8. Applications

  • Premium Anti-Aging Clear Serums & Hydrogels
  • Sensitive Skin Repair Formulations
  • Blemish-Care & Acne-Prone Skin Treatments
  • Brightening & Uneven Tone Correctors
  • Daytime Protective Skincare (Non-light-sensitizing)

Disclaimer: This document is for informational purposes for professional cosmetic formulators. The claims presented are cosmetic in nature and should be substantiated by final product testing.

PuriActives® PALMITOYL METHOXYTRYPTAMINE

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Available in Pure Crystalline Powder & NanoActive® Water-Soluble Liquid Grades

1. PRODUCT IDENTIFICATION

  • Trade Name: PuriActives® PALMITOYL METHOXYTRYPTAMINE (Pure Powder Grade) / NanoActive® PALMITOYL METHOXYTRYPTAMINE (Water-Soluble Liquid Grade)
  • INCI Name (US/EU):

Pure Powder Grade: Palmitoyl Methoxytryptamine

NanoActive® Grade: Water, Glycerin, Phospholipids, Palmitoyl Methoxytryptamine, Caprylic/Capric Glyceride

  • Chemical Name (Active): N-[2-(5-methoxy-1H-indol-3-yl)ethyl]hexadecanamide
  • CAS Number (Active): 224422-91-3
  • Molecular Formula (Active): C₂₇H₄₄N₂O₂
  • Molecular Weight (Active): 428.66 g/mol
  • Chemical Structure: CH₃-(CH₂)₁₄-CO-NH-CH₂-CH₂-C₈H₄(OCH₃)NH

2. PRODUCT DESCRIPTION

PuriActives® Palmitoyl Methoxytryptamine is a high-purity, bio-mimetic lipid-alkaloid conjugate engineered to deliver profound neuro-cosmetic soothing and cellular anti-inflammatory benefits. By coupling the potent neuro-active molecule 5-methoxytryptamine (a direct analog and precursor of melatonin) with palmitic acid, this compound exhibits exceptional skin-penetration kinetics and lipid-membrane affinity.

To address the inherent solubility limitations of the pure lipophilic crystalline powder in water-based cosmetic architectures, PuriPharm offers NanoActive® Palmitoyl Methoxytryptamine. Utilizing state-of-the-art advanced nano-delivery technology, this grade encapsulates the active within a biomimetic phospholipid bilayer membrane (average particle size < 100 nm). This advanced delivery system transforms a highly lipophilic compound into a thermodynamic-stable, optically transparent, and water-dispersible active, dramatically boosting skin bioavailability and offering effortless formulation flexibility.

3. CORE MECHANISMS OF ACTION

A. Neurogenic Soothing via TRP Channel Modulation

Sensitive skin is characterized by hyper-excited sensory nerve endings. Palmitoyl Methoxytryptamine acts as a gentle, soothing modulator of neurogenic pathways. It targets transient receptor potential (TRP) channels, specifically mitigating the over-activation of TRPV1 (capsaicin receptor), which in turn suppresses sensations of burning, stinging, tightness, and itching.

B. Anti-Inflammaging & PPAR-α Activation

Similar to endogenous endocannabinoid-like molecules (such as Palmitoylethanolamide / PEA), Palmitoyl Methoxytryptamine serves as an agonist for the nuclear receptor PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha). This activation triggers downstream anti-inflammatory cascades:

  • Inhibits the release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α.
  • Suppresses mast cell degranulation, mitigating sudden skin redness and histamine-induced itchiness.

C. Melatonin Receptor Agonism & Circadian Repair

Because 5-methoxytryptamine is a direct deacetylation analog of melatonin (N-acetyl-5-methoxytryptamine), Palmitoyl Methoxytryptamine acts as a highly potent biomimetic agent for cutaneous melatonin receptors (MT1 and MT2). This direct agonism:

  • Resets and synchronizes the skin’s biological clock genes (such as CLOCK and PER1).
  • Enhances the skin’s endogenous defense against oxidative stress induced by ultraviolet (UV) radiation and blue light.
  • Accelerates nocturnal DNA repair and cell regeneration, restoring a radiant and rested complexion overnight.

D. Enhanced Bioavailability via Lipophilic Vectoring & Nano-Carrier Delivery

  • Pure Powder: Conjugation with palmitic acid increases the partition coefficient (log P ≈ 7.15), allowing the active to integrate seamlessly into the intercellular lipid matrix of the stratum corneum.
  • NanoActive® Liquid: The phospholipid membrane of the nano-carriers fuses directly with the lipid bilayers of the stratum corneum. This bypasses the rate-limiting barrier of intercellular lipid transport, creating a “depot effect” in the viable epidermis and accelerating cellular uptake of the active molecule.

4. TECHNICAL SPECIFICATIONS

[Grade A] PuriActives® PALMITOYL METHOXYTRYPTAMINE (Pure Powder)

[Grade B] NanoActive® PALMITOYL METHOXYTRYPTAMINE (Water-Soluble Liquid)

Microbiological Specifications (Both Grades)

  • Total Aerobic Plate Count: ≤ 100 CFU/g
  • Yeasts and Molds: ≤ 10 CFU/g
  • Pathogens (E. coli, S. aureus, P. aeruginosa): Negative/g

5. COSMETIC BENEFITS & CLINICAL CLAIMS

  • Instant Neuro-Soothing: Rapidly reduces sensory discomfort, itching, and neuro-sensitivity.
  • Anti-Redness & Erythema Control: Dampens micro-vascular reactivity and controls flushing in rosacea-prone skin.
  • Skin Barrier Recovery: Accelerates epidermal barrier repair and decreases trans-epidermal water loss (TEWL).
  • Intense Inflammaging Defense: Protects structural proteins (collagen and elastin) from enzymatic degradation caused by chronic low-grade inflammation.
  • Chronobiological Renewal: Aids in resetting skin repair rhythms, restoring a radiant and rested complexion overnight.

6. FORMULATION & PROCESSING GUIDELINES (PURE POWDER)

A. Recommended Usage Levels

  • Daily Soothing & Maintenance Creams: 0.05% – 0.2%
  • Intensive SOS / Post-Procedure Care: 0.2% – 0.5%

B. Solubility & Incorporation

  • Oil Phase: Soluble in hot cosmetic esters and lipids (e.g., Caprylic/Capric Triglyceride, Squalane, C12-15 Alkyl Benzoate) at 75°C – 80°C.
  • Water Phase: Insoluble in water.

C. Processing Temperature

● Stable at temperatures up to 85°C. It is recommended to dissolve the active in the oil phase before emulsification.

7. FORMULATION & PROCESSING GUIDELINES (NANOACTIVE® LIQUID)

A. Recommended Usage Levels

  • Daily Soothing Serums & Toners: 1.0% – 4.0% (Equivalent to 0.05% – 0.2% pure active)
  • High-Concentration Clinical Soothing Ampoules: 4.0% – 10.0% (Equivalent to 0.2% – 0.5% pure active)

B. Solubility & Incorporation

  • Water Phase: 100% dispersible in water. It yields an elegant, optically transparent solution, ideal for clear gel, serum, toner, and essence formulations.
  • Incorporation: Highly recommended to add to the water phase or post-emulsification phase during the cooling stage at temperatures below 40°C.

C. Processing Guidelines & Shear Sensitivity

● Avoid exposing NanoActive® grade to high-shear homogenization equipment (e.g., rotor-stator homogenizers) for prolonged periods, as extreme shear can disrupt the lipid vesicle bilayers. Use paddle stirring or gentle marine propellers to disperse.

D. pH Stability (NanoActive®)

● Optimum stability is observed within a pH range of 4.5 – 6.5.

8. STORAGE, SHELF LIFE & REGULATORY

● Storage Conditions: Store in the original, tightly sealed container.

  • Pure Powder: Keep in a cool, dry, and well-ventilated area, preferably refrigerated at 2°C – 8°C for long-term storage.
  • NanoActive® Liquid: Do not freeze. Store at 4°C – 25°C, protected from direct sunlight and heat.

● Shelf Life: 24 months from the date of manufacture when stored under prescribed conditions.

● Regulatory Compliance: Approved for use in cosmetics worldwide (including EU, USA, and China IECIC listing). Vegan-compliant, cruelty-free, and non-GMO.

Disclaimer: The information contained in this document is provided in good faith and is based on our current technical knowledge. Formulation results may vary depending on other raw materials and processing equipment used. It is the formulator’s responsibility to conduct final product safety and efficacy tests.

PuriActives® PALMITOYL TRYPTAMINE

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Available in Pure Crystalline Powder & NanoActive® Water-Soluble Liquid Grades

1. PRODUCT IDENTIFICATION

  • Trade Name: PuriActives® PALMITOYL TRYPTAMINE (Pure Powder Grade) / NanoActive® PALMITOYL TRYPTAMINE (Water-Soluble Liquid Grade)

INCI Name (US/EU):

  • Pure Powder Grade: Palmitoyl Tryptamine
  • NanoActive® Grade: Water, Glycerin, Phospholipids, Palmitoyl Tryptamine, Caprylic/Capric Triglyceride
  • Chemical Name (Active): N-[2-(1H-indol-3-yl)ethyl]hexadecanamide
  • CAS Number (Active): 21469-15-8
  • Molecular Formula (Active): C₂₆H₄₂N₂O
  • Molecular Weight (Active): 398.63 g/mol
  • Chemical Structure: CH₃-(CH₂)₁₄-CO-NH-CH₂-CH₂-C₈H₅NH

2. PRODUCT DESCRIPTION

PuriActives® Palmitoyl Tryptamine is a high-purity, bio-mimetic lipid-alkaloid conjugate engineered to deliver profound neuro-cosmetic soothing and cellular anti-inflammatory benefits. By coupling the potent neuro-active molecule tryptamine with palmitic acid, this compound exhibits exceptional skin-penetration kinetics and lipid-membrane affinity.

To address the inherent solubility limitations of the pure lipophilic crystalline powder in water-based cosmetic architectures, PuriPharm offers NanoActive® Palmitoyl Tryptamine. Utilizing state-of-the-art advanced nano-delivery technology, this grade encapsulates the active within a biomimetic phospholipid bilayer membrane (average particle size < 100 nm). This advanced delivery system transforms a highly lipophilic compound into a thermodynamic-stable, optically transparent, and water-dispersible active, dramatically boosting skin bioavailability and offering effortless formulation flexibility.

3. CORE MECHANISMS OF ACTION

A. Neurogenic Soothing via TRP Channel Modulation

Sensitive skin is characterized by hyper-excited sensory nerve endings. Palmitoyl Tryptamine acts as a gentle, soothing modulator of neurogenic pathways. It targets transient receptor potential (TRP) channels, specifically mitigating the over-activation of TRPV1 (capsaicin receptor), which in turn suppresses sensations of burning, stinging, tightness, and itching.

B. Anti-Inflammaging & PPAR-α Activation

Similar to endogenous endocannabinoid-like molecules (such as Palmitoylethanolamide / PEA), Palmitoyl Tryptamine serves as an agonist for the nuclear receptor PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha). This activation triggers downstream anti-inflammatory cascades:

  • Inhibits the release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α.
  • Suppresses mast cell degranulation, mitigating sudden skin redness and histamine-induced itchiness.

C. Melatonin Pathway Synergy & Circadian Repair

Because tryptamine is an biochemical precursor in the melatonin and serotonin synthesis pathways, topical application of Palmitoyl Tryptamine supports the skin’s nocturnal repair mechanisms. It enhances the skin’s endogenous defense against oxidative stress induced by ultraviolet (UV) radiation and blue light, helping to maintain cellular homeostasis during sleep.

D. Enhanced Bioavailability via Lipophilic Vectoring & Nano-Carrier Delivery

  • Pure Powder: Conjugation with palmitic acid increases the partition coefficient (log P ≈ 6.83), allowing the active to integrate seamlessly into the intercellular lipid matrix of the stratum corneum.
  • NanoActive® Liquid: The phospholipid membrane of the nano-carriers fuses directly with the lipid bilayers of the stratum corneum. This bypasses the rate-limiting barrier of intercellular lipid transport, creating a “depot effect” in the viable epidermis and accelerating cellular uptake of the active molecule.

4. TECHNICAL SPECIFICATIONS

[Grade A] PuriActives® PALMITOYL TRYPTAMINE (Pure Powder)

[Grade B] NanoActive® PALMITOYL TRYPTAMINE (Water-Soluble Liquid)

Microbiological Specifications (Both Grades)

  • Total Aerobic Plate Count: ≤ 100 CFU/g
  • Yeasts and Molds: ≤ 10 CFU/g
  • Pathogens (E. coli, S. aureus, P. aeruginosa): Negative/g

5. COSMETIC BENEFITS & CLINICAL CLAIMS

  • Instant Neuro-Soothing: Rapidly reduces sensory discomfort, itching, and neuro-sensitivity.
  • Anti-Redness & Erythema Control: Dampens micro-vascular reactivity and controls flushing in rosacea-prone skin.
  • Skin Barrier Recovery: Accelerates epidermal barrier repair and decreases trans-epidermal water loss (TEWL).
  • Intense Inflammaging Defense: Protects structural proteins (collagen and elastin) from enzymatic degradation caused by chronic low-grade inflammation.
  • Chronobiological Renewal: Aids in resetting skin repair rhythms, restoring a radiant and rested complexion overnight.

6. FORMULATION & PROCESSING GUIDELINES (PURE POWDER)

A. Recommended Usage Levels

  • Daily Soothing & Maintenance Creams: 0.05% – 0.2%
  • Intensive SOS / Post-Procedure Care: 0.2% – 0.5%

B. Solubility & Incorporation

  • Oil Phase: Soluble in hot cosmetic esters and lipids (e.g., Caprylic/Capric Triglyceride, Squalane, C12-15 Alkyl Benzoate) at 75°C – 80°C.
  • Water Phase: Insoluble in water.

C. Processing Temperature

●Stable at temperatures up to 85°C. It is recommended to dissolve the active in the oil phase before emulsification.

7. FORMULATION & PROCESSING GUIDELINES (NANOACTIVE® LIQUID)

A. Recommended Usage Levels

  • Daily Soothing Serums & Toners: 1.0% – 4.0% (Equivalent to 0.05% – 0.2% pure active)
  • High-Concentration Clinical Soothing Ampoules: 4.0% – 10.0% (Equivalent to 0.2% – 0.5% pure active)

B. Solubility & Incorporation

  • Water Phase: 100% dispersible in water. It yields an elegant, optically transparent solution, ideal for clear gel, serum, toner, and essence formulations.
  • Incorporation: Highly recommended to add to the water phase or post-emulsification phase during the cooling stage at temperatures below 40°C.

C. Processing Guidelines & Shear Sensitivity

  • Avoid exposing NanoActive® grade to high-shear homogenization equipment (e.g., rotor-stator homogenizers) for prolonged periods, as extreme shear can disrupt the lipid vesicle bilayers. Use paddle stirring or gentle marine propellers to disperse.

D. pH Stability (NanoActive®)

  • Optimum stability is observed within a pH range of 4.5 – 6.5.

8. STORAGE, SHELF LIFE & REGULATORY

  • Storage Conditions: Store in the original, tightly sealed container.
  • Pure Powder: Keep in a cool, dry, and well-ventilated area, preferably refrigerated at 2°C – 8°C for long-term storage.
  • NanoActive® Liquid: Do not freeze. Store at 4°C – 25°C, protected from direct sunlight and heat.
  • Shelf Life: 24 months from the date of manufacture when stored under prescribed conditions.
  • Regulatory Compliance: Approved for use in cosmetics worldwide (including EU, USA, and China IECIC listing). Vegan-compliant, cruelty-free, and non-GMO.

Disclaimer: The information contained in this document is provided in good faith and is based on our current technical knowledge. Formulation results may vary depending on other raw materials and processing equipment used. It is the formulator’s responsibility to conduct final product safety and efficacy tests.

PuriActives® Sodium Algin Sulfate The Marine-Derived GAGs Biomimetic for Ultimate Cellular Regeneration

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Company: PuriPharm Co. Ltd.

Product Category: Active Ingredient / Anti-Aging & Skin Barrier Repair

Format: Technical & Marketing Brochure

1. Executive Summary

PuriActives® Sodium Algin Sulfate is an advanced, highly purified sulfated polysaccharide derived from premium marine brown algae. Engineered through precise biomimetic biotechnology, it acts as a structural and functional analogue to endogenous Glycosaminoglycans (GAGs), specifically Heparan Sulfate.

By mimicking the extracellular matrix’s (ECM) natural biological environment, Sodium Algin Sulfate plays a crucial role in stabilizing growth factors, reducing chronic inflammation (“inflammaging”), and accelerating deep skin tissue repair. It is the ultimate marine-biotech solution for premium anti-aging, soothing, and post-procedure recovery formulations.

2. The Scientific Rationale: A Master of the Extracellular Matrix (ECM)

As skin ages, the natural pool of Heparan Sulfate in the ECM depletes, leading to structural collapse, impaired cellular communication, and accelerated wrinkling.

PuriActives® Sodium Algin Sulfate features a precisely controlled Degree of Sulfation (DS) that closely mimics human GAGs.

  • Growth Factor Stabilization: Its negatively charged sulfated topology allows it to bind specifically to endogenous growth factors (e.g., FGF, EGF, TGF-β), protecting them from proteolytic degradation and amplifying their signaling pathways for collagen synthesis.
  • MMP Inhibition: It competitively binds to and inhibits Matrix Metalloproteinases (MMPs), particularly Hyaluronidase and Elastase, preserving the skin’s natural hyaluronic acid and elastin reservoirs.

3. Core Clinical Efficacies

I. Profound Anti-Aging & Wrinkle Reduction

By acting as a biological reservoir for growth factors, Sodium Algin Sulfate stimulates fibroblast proliferation and upregulates the synthesis of Collagen I and III. It restores the dermal-epidermal junction (DEJ) architecture, resulting in visibly firmer skin and a reduction in fine lines.

II. Rapid Barrier Repair & Soothing

Exhibiting exceptional anti-inflammatory properties, it actively downregulates pro-inflammatory cytokines (such as IL-1α and TNF-α). It accelerates epidermal re-epithelialization, making it highly effective for sensitive skin, rosacea, and post-aesthetic procedure care (e.g., post-laser, post-peel).

III. Deep, Sustained Hydration

Unlike standard humectants that merely hold water on the surface, its high molecular weight and dense charge network create a breathable, 3D bio-polymeric film. This shields against trans-epidermal water loss (TEWL) while actively modulating cellular hydration channels from within.

4. Technical Specifications & Formulation Guidelines

  • INCI Name: Sodium Algin Sulfate (and) Water (Aqua)
  • Appearance: Clear to slightly yellowish, viscous liquid.
  • Odor: Characteristic (mild marine origin).
  • Solubility: 100% soluble in water. Insoluble in oils and high concentrations of ethanol.
  • pH Value (at 20°C): 5.0 – 7.5
  • Recommended Usage Level: 1.0% – 5.0%

Formulation Advantages (The PuriPharm Edge):

  • High Compatibility: Compatible with a wide range of cosmetic chassis, including clear serums, O/W emulsions, and hydrogels.
  • Stability: Highly stable against thermal stress (up to 80°C) and light. Can be added to the aqueous phase before homogenization or post-added during the cooling phase below 40°C.
  • Synergistic Potential: Pairs perfectly with peptides, ceramides, and PuriPharm’s NanoActive® encapsulates (like NanoActive® Phloretin) for comprehensive anti-aging and barrier-repair protocols.

5. Application Horizons

  • Intensive Anti-Aging Serums: To restructure the dermal matrix and enhance firmness.
  • Dermatological Soothing Creams: For hypersensitive, reactive, or compromised skin.
  • Post-Procedure Care: Accelerating recovery after laser treatments, micro-needling, or chemical peels.
  • Scalp Care Therapies: Reducing scalp inflammation and maintaining follicular ECM health.

PuriPharm Co. Ltd.

Active Science. Advanced Delivery. Real Impact.

For technical dossiers, material safety data sheets (MSDS), or formulation assistance, please contact our R&D support team.

Email: Service@puripharm.com | Web: www.PuriActives.com

NanoActive PHLORETIN

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PURIPHARM: MOLECULAR EXCELLENCE

Bridging Science & Formulations

We empower global personal care brands through two core pillars of innovation, ensuring biological efficacy meets precise spatial delivery.

NANOACTIVE® ARCHITECTURE

PHLORETIN: THE APPLE EXTRACT

THE SOLUBILITY CHALLENGE

NANOACTIVE® PHLORETIN LIQUID

PRODUCT SPECIFICATIONS

ANTIOXIDANT EFFICACY

ANTI-INFLAMMATORY ACTION

LUMINOSITY & CLARITY

Biological Shield

Beyond traditional UV filters, NanoActive Phloretin prevents cellular damage at the DNA level:

Prevents Thymine Dimer formation.

Reduces p53 protein expression (Stress marker).

Preserves Langerhans Cells for immune defense.

FORMULATOR’S ADVANTAGE

PuriActives® Ursolene™ BZ (Benzyl Ursolate)

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Precision-Engineered Triterpenoid: The Cornerstone of Deep Dermal Rejuvenation & Structural Reconstruction

1. Product Overview

While natural pentacyclic triterpenes (like Ursolic Acid) are renowned for their exceptional biological activities, their cosmetic application has historically been bottlenecked by extremely poor lipophilicity, low skin penetration, and formulation instability (propensity to crystallize).

Enter PuriActives® Ursolene™ BZ (INCI: Benzyl Ursolate). By introducing a benzyl group to the ursolic acid backbone, we have fundamentally shifted the molecule’s partition coefficient ( log P). This precise structural modification transforms a traditional botanical extract into a highly bioavailable, oil-soluble powerhouse. It precisely targets the Extracellular Matrix (ECM) architecture, offering a definitive solution for intrinsic/extrinsic aging, loss of elasticity, and compromised skin barriers.

The Core Edge: The perfect synergy of a naturally derived core and rational structural design, bridging the gap between pharmaceutical-grade precision and cosmetic applicability.

2. Key Biological Pathways & Mechanism of Action

PuriActives® Ursolene™ BZ operates through a multi-target mechanism, mitigating tissue senescence at the cellular level:

MMP Modulation & ECM Protection: Acts as a potent competitive inhibitor of Matrix Metalloproteinases (specifically MMP-1 and MMP-9), halting the enzymatic degradation cascade of collagen and elastin networks.

Fibroblast Activation via TGF-β Pathway: Stimulates the transforming growth factor-beta (TGF-β) signaling pathway, upregulating COL1A1 and COL3A1 gene expression to drive the de novo synthesis of structural proteins.

Inflammaging Mitigation: Suppresses the cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) pathways, interrupting the chronic micro-inflammatory cascades that accelerate tissue aging.

Epidermal Lipid Biosynthesis: Upregulates serine palmitoyltransferase (SPT) activity, driving endogenous ceramide production to fortify the stratum corneum barrier.

3. Proven Efficacy (In Vitro & In Vivo Highlights)

Our rigorous efficacy testing matrix demonstrates statistically significant improvements compared to vehicle and unmodified free ursolic acid controls.

In Vitro: Dermal Architecture Support

  • + 42% Increase in Pro-collagen I synthesis (Primary human fibroblasts, at 10μM, ).
  • – 65% Reduction in UV-induced elastase activity, effectively preserving skin recoil capacity.

In Vivo Clinical Study: Facial Micro-Topography (28-Day Study)

A double-blind, placebo-controlled clinical study on 30 female volunteers (aged 45-65), applying a 0.2% PuriActives® Ursolene™ BZ cream twice daily.

● Wrinkle Depth (Ra): Significant reduction of 21.4% in the periocular region.

● Skin Density: Ultrasound imaging revealed a +15% increase in dermal echogenicity, indicating structural redensification of the dermis.

4. Formulation & Technical Guidelines

PuriActives® Ursolene™ BZ is engineered for the ultimate formulator experience. Its esterified structure completely circumvents the notorious crystallization issues of free ursolic acid, enabling the creation of highly stable, cosmetically elegant emulsions.

● INCI Name: Benzyl Ursolate

● Appearance: White to off-white crystalline powder

● Solubility: Soluble in cosmetic esters (e.g., Caprylic/Capric Triglyceride, Squalane), ethanol, and glycols. Insoluble in water.

● Recommended Usage Level: 0.05% – 0.30%

● Formulation Integration: Add to the heated oil phase ( 70~80℃ ) and stir until fully dissolved before emulsification.

● Optimal pH Range: 4.5 – 6.5

5. Sustainability & Purity

PuriActives® Ursolene™ BZ is derived from upcycled apple pomace and rosemary extract precursors, synthesized via a highly efficient, atom-economical esterification process. We guarantee an ultra-high purity active (HPLC ＞ 95%) while minimizing our environmental footprint.

Recommended Applications:

● Premium Anti-Aging Night Creams

● Intensive Barrier Repair Serums

● Dermo-cosmetics (Post-Procedure Care)

● Sun Recovery & “Anti-Inflammaging” Formulations