PuriActives® BioFuco™ Powder
A Microbiome-Friendly Prebiotic Powder Blend
A tri-saccharide system for skin and scalp microbiome balance
INCI: Biosaccharide Gum-1 · Xylitol · Lactitol
Microbiome balance · Barrier & hydration · Smart powder format
Product Technology & Market Introduction · Cosmetic Active Ingredient
01 · SKIN ECOLOGY
The Next Logic of Skincare: Skin Is an Ecosystem
Skin is more than a physical barrier — it is an ecosystem built by microorganisms, sebum, water, and immune cells together. Resident flora occupy ecological niches, produce antimicrobial molecules, and “educate” the immune system: they are the first “living line of defense” of skin homeostasis.
When the flora falls out of balance (dysbiosis), dryness, sensitivity, breakouts, and dandruff follow — the answer is to restore balance, not to eliminate indiscriminately.
Dryness & flaking · Sensitivity & redness · Breakouts · Dandruff— all are scientifically linked to microbiome imbalance
| 106microorganisms / cm²Order of magnitude of microbial density on healthy skin | ≈1,000bacterial species identified on human skinDiversity is closely tied to skin health |
Sources: Grice & Segre, Nat Rev Microbiol, 2011; Byrd et al., Nat Rev Microbiol, 2018.
02 · WHY THE MICROBIOME
From “Killing” to “Nurturing”: The Shift Toward Microbiome Balance
Traditional Antimicrobial Logic｜KILL THEM ALL
Broad-spectrum antimicrobials remove microbes indiscriminately; resident and pathogenic flora are damaged alike; the ecological vacuum lets pathogens rebound faster; barrier and flora homeostasis are repeatedly disrupted.
Microbiome Balance Logic｜BALANCE THE ECOSYSTEM
Provide sugar substrates usable by resident flora; selectively limit pathogen adhesion and biofilms; restore the natural balance of niche competition; a better microenvironment builds a stronger barrier.
Sources: Byrd et al., Nat Rev Microbiol, 2018; Katsuyama et al., J Dermatol Sci, 2005.
03 · PRODUCT CONCEPT
BioFuco™ Powder: A Tri-Saccharide Prebiotic Active
Biosaccharide Gum-1｜A Fucose-Rich Polysaccharide
A fermentation-derived polysaccharide. Film-forming water lock for lasting hydration; soothing and skin-friendly with high skin affinity; enhances formulation sensory feel.
Xylitol｜A Prebiotic Five-Carbon Sugar Alcohol
A prebiotic pentitol. A selective substrate for resident flora; upregulates filaggrin to support the barrier; limits pathogen adhesion and biofilm formation.
Lactitol｜A Prebiotic Disaccharide Alcohol
A prebiotic disaccharide polyol. Selectively utilized by beneficial bacteria; a multi-hydroxyl hydrating structure; improves scalp and skin comfort.
Polysaccharide network × prebiotic sugar alcohols × microbiome modulation — not a simple blend, but a synergistic active system designed around the skin ecosystem.
| PositioningMicrobiome-friendly activePrebiotic skin-conditioning system | Technical ProfileFermentation biotechnologyPreservative-free powder |
04 · SYNERGY SYSTEM
The Tri-Saccharide System: One Synergistic Eco-Active
Microbiome Modulation
Selectively feeds resident flora while restraining opportunistic pathogens.
Barrier Support
Xylitol upregulates filaggrin and reduces TEWL.
Lasting Hydration
Film-forming + humectant sugars + endogenous NMF.
Soothing Comfort
The fucose-rich polysaccharide soothes sensitive, reactive skin.
The synergy logic is based on published research evidence for each component; see the evidence page and source notes.
05 · PREBIOTIC MODULATION
Selective Prebiotics: Feed the Residents, Restrain the Opportunists
Staphylococcus epidermidis
Resident flora · produces antimicrobial peptides · maintains homeostasis
1% xylitol significantly promotes growth; higher growth rate in pure culture (p < 0.001).
Staphylococcus aureus
Opportunistic pathogen · linked to atopic skin concerns · can form biofilms
5% xylitol significantly inhibits growth; growth suppressed in pure culture (p < 0.001).
Cutibacterium acnes
Common in sebum-rich areas · overgrowth linked to breakouts
5% xylitol significantly inhibits growth; both tested strains suppressed (p < 0.005–0.001).
Mechanism: xylitol is difficult for opportunistic pathogens such as S. aureus to ferment, yet can be metabolized by specific resident flora; it also inhibits S. aureus glycocalyx synthesis and biofilm formation — the essential difference between prebiotic modulation and broad-spectrum antimicrobial action. Lactitol is likewise selectively utilized by beneficial bacteria in microbiome models.
Sources: Anglenius et al., Korean J Microbiol, 2020 (in vitro, pure culture); Katsuyama et al., J Dermatol Sci, 2005; lactitol prebiotic evidence: Björklund et al., Age, 2012 (microbiome model).
06 · REBUILDING THE NICHE
Beyond Inhibition — Rebuilding a Resident-Dominated Niche
Selectivity Is Clear
The combination inhibits biofilm formation by opportunistic S. aureus by up to 64.7%, while affecting resident S. epidermidis by only < 2.5%.
Co-Culture Confirmation
The system reversed the growth advantage of S. aureus, restoring dominance to S. epidermidis — niche competition shifted back toward health.
In-Vivo Echo
A xylitol-containing cream applied to atopic dry skin significantly reduced S. aureus colonization and improved dryness within 4 weeks.
Source: Katsuyama et al., J Dermatol Sci, 2005 (Part 2, human study).
07 · SKIN BARRIER
Microbiome → Barrier → Skin Resilience
Human evidence: barrier support (14 days, n = 12, dry skin).
| TEWL ↓TEWL significantly reduced; barrier function improved | Filaggrin ↑More filaggrin-positive epidermal cells (~25% vs. control) | Hydration ↑Stratum corneum hydration and biomechanics improved together |
A 5% glycerol + 5% xylitol formula used for 14 days: TEWL fell significantly while skin hydration, epidermal and dermal thickness, and the DEJ undulation index all rose; in-vitro data identify xylitol as the key component upregulating filaggrin expression.
In an SLS acute-irritation human model, xylitol and glycerol showed dose-dependent anti-irritant and anti-inflammatory effects — direct evidence for sensitive-skin and compromised-barrier scenarios.
Sources: Korponyai et al., Acta Derm Venereol, 2017 (in vivo); Szél et al., J Eur Acad Dermatol Venereol, 2015 (in vivo).
08 · HYDRATION
A Triple Hydration Mechanism: Film · Humectancy · NMF
8hBiosaccharide Gum-1 hydration lasts 8 hours in human testingIngredient technical dossier (in-vivo volunteer study)
01 Film-Forming — a “Breathable Moisture Film”
The high-molecular-weight polysaccharide forms a non-occlusive moisturizing film on the skin surface, slowing water loss for immediate and long-lasting hydration with a silky, non-sticky feel.
02 Humectancy — Hydrogen-Bond “Water Capture”
The multi-hydroxyl structures of xylitol and lactitol bind water molecules through hydrogen bonds, raising stratum corneum water content and maintaining dynamic moisture balance even in dry environments.
03 Endogenous NMF — Upregulating Filaggrin
Xylitol upregulates filaggrin expression in keratinocytes — filaggrin breakdown products are the primary source of natural moisturizing factor (NMF), reinforcing hydration from within rather than relying on external humectants alone.
Sources: Korponyai et al., Acta Derm Venereol, 2017; Cohen et al., J Chem Soc Faraday Trans, 1993; Biosaccharide Gum-1 ingredient technical dossier (in vivo).
09 · SOOTHING & COMFORT
The Skin-Friendly Science of a Fucose-Rich Polysaccharide
Fucose is a natural component of human glycoproteins and glycolipids — skin “recognizes” Biosaccharide Gum-1, which is naturally highly affine and highly tolerated.
This makes it a time-proven soothing ingredient for sensitive and reactive skin care.
Sources: Biosaccharide Gum-1 ingredient technical dossier (in-vivo volunteer testing); Szél et al., J Eur Acad Dermatol Venereol, 2015 (in vivo); CIR Expert Panel safety assessment of microbial polysaccharide gums.
PART II · THE SMART POWDER FORMAT
From Liquid Actives to a Smart Powder
A more stable, more convenient, more efficient delivery form for a microbiome active
10 · WHY POWDER
Why a Powder: Five Pain Points of Liquid Actives, Solved One by One
Preservative-Free Format
Low water activity inhibits microbial growth, reducing reliance on preservatives.
Easy to Store
A solid form — simply sealed at room temperature; stable in long-term inventory.
Easy to Ship
Over 95% of water weight removed; built for global supply chains.
Easy to Handle
Free-flowing and non-caking; convenient to weigh and dose in both lab and production.
Easy to Disperse
Disperses quickly and evenly in the water phase; suitable for transparent formulas as well.
| Traditional Liquid Actives | BIOFUCO™ POWDER |
|---|---|
| ~97% water · requires a preservation system | Solid composite powder · low water activity by design |
| Heavy to ship · shelf life challenged by microbes | Light to ship · storage-friendly · flexible supply chain |
| Low-dose actives are hard to weigh precisely | Solid dilution ensures weighing and dispersion accuracy |
The format comparison is based on the typical ~97% water content of liquid products in public technical literature; actual formulation performance should be verified.
11 · SMART SOLID DILUTION
Smart Solid Dilution: Every Milligram Under Precise Control
What It Means for Formulators
- Accurate dosing: gram-scale handling with milligram-level precision.
- Uniform dispersion: no local concentration spikes.
- Non-caking: free-flowing and disperses instantly in water.
- Scalable dosing: seamless scale-up from lab to production.
- Standardized delivery: consistent active content from batch to batch.
- High efficacy at low dose: a 1%–2% reference use level delivers the designed activity.
Use levels are reference ranges and should be optimized against formulation goals; the solid dilution process is a product design description.
12 · SCALP MICROBIOME
The Scalp: An Ecosystem That Also Needs Balance
The microbial fingerprint of dandruff: lipophilic Malassezia rises from 46% to 74%–83%, while resident C. acnes falls from 26% to single digits — dandruff is fundamentally a flora-imbalance problem.
The cascade of imbalance: dysbiosis accompanies elevated TEWL and pH plus a compromised scalp barrier, leading to dryness, itching, flaking, and scalp sensitivity.
A new care target: maintain scalp flora homeostasis and nourish the resident ecology — the next generation of scalp care beyond “aggressive anti-dandruff.”
13 · SCALP EVIDENCE
Xylitol × Lactitol: Evidence for Scalp Hydration and Barrier
Study Design
28 volunteers (16 women / 12 men) used a xylitol–lactitol wash-and-care regimen 3 times over 10 days — shampoo 1% + conditioner 1% + leave-on product 2%, against a placebo control.
Results
Scalp hydration rose +27% immediately and held at +17% on day 10; TEWL improved by -12.7% (trend); video microscopy showed regulated desquamation and stronger scalp barrier integrity.
Implication
By restoring scalp ecological balance — feeding beneficial flora and restraining harmful flora — dryness, itching, and dandruff discomfort are relieved at the source.
14 · SKINCARE APPLICATIONS
Skincare Applications: From Concept to Everyday Formulas
Microbiome Concepts
Microbiome skincare serums · prebiotic / postbiotic creams · post-cleansing microbiome care · flora-balancing lotions
Targeted Care
Soothing care for sensitive skin · barrier-repair creams · long-lasting hydrating serums and masks · microbiome care for blemish-prone skin
Gentle Scenarios
Gentle baby and child care · hydrating soothing mists · cleansers and rinse-off products · after-sun repair gels
Positioning: a microbiome-friendly active · a prebiotic skin-conditioning systemSuitable for leave-on and rinse-off systems; the water-soluble powder fits serums, creams, masks, mists, and cleansers.
Whether for a new “flora balance” concept launch or a sensitive-skin formula that pairs soothing with barrier support, BioFuco™ Powder delivers a clear scientific narrative and formulator-friendliness through a concise INCI combination.
15 · HAIR & SCALP CARE
From Scalp Ecology to Hair Condition
| Scalp MicrobiomeBalanced scalp flora | Scalp BarrierScalp barrier integrity | Comfort & HydrationComfort and moisture | Healthy HairA healthy environment for hair |
Typical Product Applications
- Microbiome shampoos
- Leave-on scalp serums
- Soothing scalp mists
- Conditioners and hair masks
- Anti-dandruff support care
- Products for sensitive scalps
Bonus: the film-forming property of Biosaccharide Gum-1 can remain on the hair fiber surface after rinsing, helping smooth the cuticle and enhance smoothness and shine (ingredient technical dossier).
16 · FORMULATOR-FRIENDLY
For Formulators: Usage Guide and Technical Notes
| Item | Recommendation |
|---|---|
| Reference use level | 0.5%–2.0% (reference range; optimize per formulation goals and efficacy positioning) |
| Phase of addition | Add to the water phase; ≤45°C for emulsion systems, room temperature for gels and aqueous systems |
| Dissolution & dispersion | Sprinkle slowly into the water phase under stirring; disperses and dissolves within minutes; pre-disperse and sieve for transparent formulas |
| pH suitability | 4.0–8.0 (reference range; suits mildly acidic to neutral systems) |
| Compatibility & compliance | Good compatibility with common surfactants, thickeners, and preservation systems (reference); all three ingredients are IECIC-listed cosmetic raw materials; xylitol has been assessed by CIR |
The above is a reference guide based on the ingredient’s public technical documentation and does not constitute precise process parameters; final formulation parameters should be confirmed through laboratory validation and stability testing.
17 · EVIDENCE CHAIN
The Evidence Chain: Mechanism → Evidence → Benefit
| Mechanism | Key Evidence (Source · Level) | Cosmetic Benefit |
|---|---|---|
| Selective microbiome modulation | 1% xylitol promotes S. epidermidis; 5% inhibits S. aureus / C. acnes — Anglenius et al., Korean J Microbiol, 2020 · in vitro | Microbiome-friendly concept |
| Anti-biofilm & niche rebuilding | Xylitol inhibits S. aureus glycocalyx and biofilms — Katsuyama et al., J Dermatol Sci, 2005 · in vitro + human; prebiotic blend inhibits S. aureus biofilms by up to 64.7% — Di Lodovico et al., Microorganisms, 2021 · in vitro | Blemish-prone and sensitive skin care |
| Barrier strengthening | Filaggrin expression up, TEWL significantly down (14 days, n=12) — Korponyai et al., Acta Derm Venereol, 2017 · human | Barrier repair |
| Triple hydration | Polysaccharide film hydrates for 8 hours — ingredient dossier · human; polyol hydrogen bonding to water — Cohen et al., 1993; filaggrin/NMF upregulation — Korponyai et al., 2017 | Long-lasting hydration |
| Soothing & comfort | Post-challenge volunteer testing confirms soothing — ingredient dossier · human; dose-dependent anti-irritation in the SLS model — Szél et al., JEADV, 2015 · human | Sensitive-skin comfort |
| Scalp microbiome care | Scalp hydration +27% (immediate) / +17% (day 10), TEWL -12.7% (day 10, n=28) — PCT/IB2004/004345 patent-family clinical data · human | Scalp and hair care |
In-vitro / dossier data ≠ finished-product clinical efficacy; third-party literature is for technical reference only and does not represent results for the BioFuco™ Powder finished formulation.
SUMMARY & CONTACT
Feed the beneficial flora. Balance the microbiome.
| Microbiome BalanceFeed residents, restrain opportunists | Barrier SupportFilaggrin · TEWL · NMF | HydrationFilm + humectancy + NMF |
| Skin ComfortSoothing for sensitive skin | Scalp CareBacked by clinical evidence | Smart Powder FormatPreservative-free · easy to use |
PuriActives® BioFuco™ Powder — the prebiotic powder for skin and scalp microbiome balance
PURIPHARM CO., LTD.
www.puriactives.com · service@puripharm.com · +86-572-2745768Building 6, No. 1366 Hongfeng Road, Huzhou, Zhejiang, China
This material is for cosmetic ingredient introduction only and does not constitute pharmaceutical claims; in-vitro and ingredient dossier data are not equivalent to finished-product clinical efficacy; cited third-party literature is for technical reference only. PuriActives® and BioFuco™ are trademarks of PURIPHARM CO., LTD.
