1. Epigenetics and Skin Aging
What is Epigenetics?
Epigenetics is the science studying how lifestyle and environmental factors influence gene expression.
This process occurs without changing the underlying DNA sequence.
Instead, it alters gene activity by turning genes “on” or “off” based on external stimuli.
It provides a profound new target for anti-aging interventions by addressing the root causes of cellular decline.
The Identical Twins Study
Primary Drivers of Skin Aging
The Process of DNA Methylation
Lifestyle and environmental factors influence gene expression primarily through DNA methylation.
Methyl groups (epigenetic factors) attach to the DNA molecule.
These methylation marks can activate or, more commonly in aging, improperly repress or “silence” specific genes.
This makes the DNA inaccessible to the machinery that keeps cells youthful and functional.
Hypermethylation and Aging
2. The DHM Breakthrough
Introducing Dihydromyricetin: The world’s first cosmetic DNA methylation inhibitor.
A Global Innovation
Dihydromyricetin (DHM)：
NanoActive DHM features Dihydromyricetin, globally recognized as the first cosmetic ingredient scientifically proven to inhibit DNA methylation. This represents a paradigm shift, leading a completely new direction in epigenetic anti-aging interventions.
Mechanism of Action
Inhibit Methylation: DHM acts directly at the genetic level to regulate and inhibit the excessive DNA methylation patterns that accumulate over time.
Reactivate Youth Genes: By removing these inhibitory methyl tags, DHM successfully reactivates silenced youth genes.
Restore Vitality: This fundamentally delays cellular aging by returning skin cells to their peak functional state, rather than just treating surface symptoms.
Natural Plant Source
NanoActive DHM is extracted exclusively from Ampelopsis Grossedentata, commonly known as Vine Tea.
It belongs to the Vitaceae family, Ampelopsis genus.
This specific plant is exceptionally rich in naturally occurring Dihydromyricetin.
It provides a clean, sustainable, and highly potent botanical source for epigenetic anti-aging formulations.
Cultivation & Extraction
3. Advanced Nanoliposome Technology
Nanoliposome Principles
Definition: Nanoliposomes are microscopic vesicles composed of phospholipid bilayers that perfectly mimic the human cell membrane structure.
Average Size: Ranging from 10 to 50 nm, they are perfectly sized to penetrate the skin barrier effectively.
Encapsulation: They possess a high drug entrapment efficiency, capable of securely encapsulating both hydrophobic and hydrophilic active ingredients like DHM.
Technology Advantages
The Dual Breakthrough
4. Clinical Efficacy and Validation
DNA Methylation Impact
Reversing the Clock
Under experimental conditions (20µM DHM over 6 weeks on a skin equivalent model), DHM treatment significantly affected over 10,000 methylation sites. It successfully induced a young epidermal DNA methylation pattern, restoring youthful epigenetic characteristics.
Epidermal Structure Improvement
Reactivation of Youth Genes
5. Market Application & Value
Competitive Advantage
Target Market & Applications
