NanoActive DHM

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NanoActive DHM Epigenetic Youth Restorer & DNA Methylation Inhibitor

1. PRODUCT IDENTIFICATION

  • Product Name: NanoActive DHM
  • Trade Name: NanoActive DHM by PuriPharm
  • INCI Name: Water, Glycerin, Caprylic/Capric Triglyceride, Ampelopsis Grossedentata Extract, Phospholipids, Tocopheryl Acetate.
  • Botanical Source of Active: Ampelopsis grossedentata(Vine Tea)
  • Active Content: 9.5% – 10.5% (Ampelopsis Grossedentata Extract)

2. PRODUCT DESCRIPTION

NanoActive DHM represents a paradigm shift in epigenetic anti-aging. Developed by PuriPharm Co. Ltd., it is the industry’s first cosmetically viable DNA methylation inhibitor. Utilizing advanced nanoliposomal technology, highly purified Dihydromyricetin (DHM) is encapsulated in a biomimetic phospholipid bilayer. This sophisticated delivery system overcomes the inherent instability and poor skin penetration of DHM, allowing for targeted delivery to the deep epidermis and dermis, fundamentally reversing cellular aging at the genetic transcription level.

3. MECHANISM OF ACTION

Environmental stressors (UV, pollution) and intrinsic aging lead to hypermethylation of DNA, which functionally “silences” essential youth and structural genes.

  • Epigenetic Reversal: NanoActive DHM acts as a potent DNA methylation inhibitor, effectively removing age-induced methyl tags.
  • Gene Reactivation: By modulating over 10,000 methylation sites, it reactivates silenced genes associated with the Extracellular Matrix (ECM), signal transduction, and autophagy.
  • Targeted Delivery: The 50-150 nm liposomal spheres ensure enhanced transdermal absorption and a sustained-release profile, maximizing biological availability and minimizing potential irritation.

4. TECHNICAL SPECIFICATIONS

5. EFFICACY & CLINICAL DATA SUMMARY

  • Transcriptomic Upregulation: Significantly upregulates key structural genes including COL6A1 (Collagen Type VI), ITGB6, ITGA5, and VCL, restoring cellular anchorage and tissue firmness.
  • 3D Skin Equivalent Model: In a 6-week in vitrostudy utilizing 20µM DHM on mature 3D skin models, NanoActive DHM effectively reversed epidermal thinning. Epidermal thickness increased from 30µm (untreated mature control) to ~50µm, closely mirroring the baseline of young skin models (60µm). Statistical significance achieved (p = 0.00064).

6. FORMULATION GUIDELINES

NanoActive DHM is designed for ease of use in premium cosmetic formulations.

  • Recommended Usage Level: 1.0% – 5.0%
  • Incorporation Phase: Add to the aqueous phase or during the cooling phase (below 45°C) for emulsions to maintain liposomal integrity.
  • pH Compatibility: Stable within a final formulation pH range of 4.5 – 7.5.
  • Incompatibilities: Avoid high concentrations of strong ionic surfactants or extreme ethanol levels (>20%) which may disrupt the lipid bilayer.
  • Processability: Do not subject to intense, prolonged shear force (homogenization > 3000 rpm for extended periods) after incorporation.

7. TARGET APPLICATIONS

  • Premium Anti-Aging Skincare: Serums, night creams, and eye treatments targeting chronological aging and photoaging.
  • Medical Aesthetics Post-Care: Restorative formulations designed to prolong the effects of clinical treatments by maintaining epigenetic cellular health.
  • Preventative Aging: Solutions targeting millennials/Gen-Z exposed to urban pollution, stress, and lifestyle-induced epigenetic damage.

8. STORAGE & SHELF LIFE

  • Storage Conditions: Store in a cool, dry place away from direct sunlight. Recommended storage temperature: 4°C – 25°C. Do not freeze. Keep containers tightly sealed when not in use.
  • Shelf Life: 24 months from the date of manufacture under optimal storage conditions.

Disclaimer: The information provided herein is based on our current knowledge and rigorous scientific testing. It is intended for informational purposes for cosmetic professionals and formulators. It is the responsibility of the formulator to ensure the stability, safety, and regulatory compliance of the final consumer product.

PuriPharm Co. Ltd.Pioneering Epigenetic Skincare SolutionsWebsite: www.puriactives.com | Email: service@puripharm.com

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