Tag Archives: bioactive ingredients

NanoActive™ Phloretin Redefining Efficacy with Advanced Nano-Delivery Technology

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1. Product Overview

Phloretin, an extraordinary dihydrochalcone polyphenol derived from the root bark of Malus domestica (apple tree), is celebrated for its multi-functional benefits: remarkable tyrosinase inhibition, potent radical scavenging, and cellular DNA protection. However, traditional crystalline Phloretin is notoriously difficult to formulate due to poor water solubility, high oxidation susceptibility, and inability to penetrate the stratum corneum barrier effectively.

PuriPharm introduces NanoActive™ Phloretin—powered by our proprietary Advanced Nano-Delivery System Technology. By encapsulating Phloretin within a sub-50nm nanostructured lipid matrix, we have unlocked its full potential, transforming nature’s most potent antioxidant into a stable, highly bioavailable formulation solution.

2. Key Benefits at a Glance

Breakthrough Bioavailability: Amphiphilic architecture enables seamless delivery across skin barriers.

Enhanced Stability: Protects the active payload from premature oxidation and degradation.

Formulation Freedom: Cold-processable, 100% water-dispersible, and prevents recrystallization or color shift.

Unmatched Potency: Delivers 94% radical scavenging efficiency and powerful tyrosinase inhibition (IC50 = 37.5 μmol/L).

3. The Science Behind the Innovation

Advanced Whitening & Melanin Regulation

Acts at the cellular level to inhibit tyrosinase activity. Fades post-inflammatory hyperpigmentation (PIH) and dramatically improves skin luminosity (L* value) without irritation.

Broad-Spectrum Antioxidant Matrix

Neutralizes reactive oxygen species (ROS) far more effectively than crystalline alternatives. The nano-delivery system ensures max dispersion in aqueous environments, achieving 94% scavenging efficiency—outperforming standard Vitamin C.

Acne Mitigation & Sebum Control

Targets sebaceous glands to reduce excess lipogenesis while inhibiting pro-inflammatory markers (PGE2, COX-2). Promotes a long-lasting matte finish and accelerates blemish recovery.

Deep Cellular DNA Defense

Shields cellular DNA from UV-induced Thymine Dimer formation and prevents the degradation of collagen by blocking MMP-9 expression, addressing the root causes of photoaging.

4. Applications & Guidelines

INCI Name: Phloretin, Phospholipids, Caprylic/Capric Triglyceride, Glycerin, Water

Recommended Use Level: 0.5% – 2.0%

Optimal pH: 4.5 – 6.5

Applications: Premium skin brightening serums, daily antioxidant defense lotions, anti-acne spot treatments, and cellular repair night creams.

Formulator’s Note: Ideal for cold-process formulations (add < 45°C). Compatible with high-clarity clear serums, O/W emulsions, and gels.

5. Storage & Safety

Storage Conditions: Store between 4°C and 25°C. Protect from direct light and localized thermal sources. No strict cold chain required.

Safety Profile: 0.0% irritation index in patch testing. Non-phototoxic, non-sensitizing, and GMO-free.

NanoActive® Phyto-Retinal Booster

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The Ultimate Synergy of Retinaldehyde and Silymarin: Pioneering Advanced Bioretinoid Therapy

Manufacturer: PuriPharm Co. Ltd.

Product Category: High-efficacy Functional Actives (PuriActives®) / Advanced Nano Delivery Systems (NanoActive®)

INCI Name: Water, Glycerin, Phospholipids, Retinal, Silybum Marianum (Milk Thistle) Extract, Caprylic/Capric Triglyceride

1. Product Concept: Solving the “Retinoid Paradox”

In the landscape of dermatology, Retinoids remain the gold standard for age-reversal. However, the industry has long been hindered by the “Retinoid Paradox”—the inverse relationship between biological potency and skin tolerance.

  • The Demand for High-Potency Anti-Aging: Traditional Retinol requires two metabolic oxidation steps to become active, often leading to “Retinoid Dermatitis” (peeling, erythema) at effective concentrations.
  • The Sensitive Skin Frontier: There is a critical market need for a solution that provides deep dermal restructuring without compromising the integrity of the epidermal barrier.

NanoActive® Phyto-Retinal Booster overcomes these challenges by integrating Retinaldehyde (the one-step precursor to Retinoic Acid) with Silymarin (a natural bio-shield) within a proprietary nano-encapsulation matrix. This is not merely a combination of ingredients, but a fundamental reconfiguration of skin pharmacokinetics.

2. Bio-Actives & Molecular Mechanisms

I. Retinaldehyde (Retinal): The “One-Step” Metabolic Pathway

Retinaldehyde is the direct precursor to Retinoic Acid. By bypassing the slow, rate-limiting oxidation step required by Retinol, it delivers superior performance:

  • Metabolic Efficiency: Retinal is converted into active Retinoic Acid up to 11 times more efficiently than Retinol within skin cells.
  • Targeted Remodeling: It actively triggers fibroblasts to up-regulate Collagen Type I, Type III, and Elastin, significantly strengthening the Dermo-Epidermal Junction (DEJ).

II. Silymarin: The Phyto-Shield against Inflammaging

Silymarin acts as both a biological buffer and a potent anti-aging active in its own right:

  • Inhibiting Inflammaging: By precisely inhibiting the NF-κB signaling pathway, Silymarin blocks the release of pro-inflammatory cytokines, fundamentally mitigating the risk of “Retinoid-induced” irritation.
  • Molecular Stabilization: Its robust radical scavenging capacity neutralizes UV-induced ROS, shielding the sensitive Retinal molecule from photodegradation.

3. NanoActive® Advanced Delivery System

Utilizing biomimetic phospholipid bilayer technology, PuriPharm encapsulates these actives into ultra-fine vesicles (~10-100nm) for “Smarter Delivery”:

  • Superior Permeation: The extremely small particle size (~50nm average) allows the vesicles to navigate the intercellular lipid matrix, reaching the basal layer and upper dermis with ease.
  • Controlled Release & Bioavailability: By mimicking the skin’s natural cell membranes, the system ensures high compatibility and a sustained release profile, preventing the “concentration spikes” that cause acute irritation.
  • Chemical Shielding: Provides a physical barrier against oxygen and UV radiation, dramatically extending the shelf-life and efficacy of the Retinal molecule in final formulations.

4. Technical Advantages & Formulation Guidelines

  • Water-soluble: Unlike conventional hydrophobic Retinal, this system is fully water-dispersible, allowing for the creation of high-performance serums, lightweight night creams, and even transparent formulations.
  • Enhanced Safety Profile: Clinical evaluations demonstrate a reduction in irritation scores by over 60% compared to free Retinol at equivalent biological activity levels.
  • Color & Stability: Yellow to brownish-yellow viscous liquid. Our stabilization technology prevents the severe browning/yellowing issues common with traditional Retinal powders.

5. Efficacy Data: From Science to Results

  • Cellular Regeneration: +45% increase in Keratinocyte proliferation within 72 hours (in-vitro).
  • Genetic Up-regulation: mRNA expression for Collagen Type I and III increased by over +120%.
  • Clinical Efficacy: 28-day in-vivo studies show significant reduction in wrinkle depth and visible improvements in skin density and luminosity.

6. Application Guidelines

  • Recommended Dosage: 1.0% – 5.0%
  • Optimal pH Range: 4.5 – 6.5 (Aligns with skin’s natural acidity while maximizing carrier stability).
  • Processing: Cold process highly recommended; add at the end of the manufacturing cycle.

PuriPharm Co. Ltd. (浦瑞生物医药技术有限公司)

Leading Advanced Nano Delivery: Transforming Molecular Science into Exceptional Efficacy.

ACTIVE SCIENCE. ADVANCED DELIVERY. REAL IMPACT.

From Science to Results.

Contact: service@puripharm.com

NanoActive 4-TERPINEOL: The Pure Power of Tea Tree, Delivered with Nano-Precision

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1. Product Overview

NanoActive 4-TERPINEOL is a highly purified, nanostructured lipid carrier (NLC) encapsulated formulation of 4-Terpineol, the most potent and functional active ingredient naturally found in Melaleuca alternifolia (Tea Tree) oil.

By isolating the highly active 4-Terpineol and utilizing PuriPharm’s proprietary NanoActive™ Delivery Technology, we have created a next-generation active ingredient. It offers exceptional broad-spectrum antimicrobial and anti-inflammatory properties while completely bypassing the classical limitations of traditional essential oils, such as poor water solubility, high volatility, pungent odor, and skin sensitization.

INCI Name: 4-Terpineol, Phospholipids, Glycerin, Water

Appearance: Opalescent to translucent liquid

Recommended Usage: 1.0% – 5.0%

2. The Challenge & The PuriPharm Solution

The Limits of Conventional 4-Terpineol

While 4-Terpineol is scientifically proven to be vastly superior to whole Tea Tree Oil in targeting Cutibacterium acnes and Demodex mites, its use in cosmetic formulations has been severely hindered:

  1. Formulation Incompatibility: Highly lipophilic and totally insoluble in water.
  2. Sensory Issues: Strong, characteristic medicinal odor that is difficult to mask.
  3. Instability: Prone to volatilization and oxidation during storage.
  4. Irritation: High concentrations can compromise the skin barrier and cause erythema.

The NanoActive™ Breakthrough

PuriPharm has engineered a sub-micron encapsulation system (particle size: 10nm – 100nm). The active 4-Terpineol is safely enclosed within a biocompatible phospholipid bilayer.

  • Total Water Solubility: Transforms a highly lipophilic compound into an easily dispersible, clear aqueous system.
  • Odor Masking: The lipid encapsulation significantly reduces the characteristic terpene odor, allowing for elegant, fragrance-free formulations.
  • Targeted Follicular Delivery: The lipophilic nature of the nanocarrier ensures targeted accumulation in the pilosebaceous unit, precisely where C. acnes and sebum reside.
  • Sustained Release & Zero Irritation: Controlled release kinetics prevent immediate spikes in local concentration, minimizing irritation and extending efficacy.

3. Mechanism of Action & Efficacy

A. Broad-Spectrum Antimicrobial & Anti-Parasitic Activity

NanoActive 4-TERPINEOL acts directly on the microbial cell membrane, disrupting its integrity without inducing bacterial resistance.

  • Acne Management: Exhibits a remarkably low Minimum Inhibitory Concentration (MIC) against Cutibacterium acnes and Staphylococcus aureus.
  • Scalp & Dandruff: Highly effective against Malassezia furfur, balancing the scalp microbiome.
  • Rosacea & Demodex: A proven, potent agent for paralyzing and eradicating Demodex folliculorum (face mites), a key trigger for rosacea and adult acne.

B. Immunomodulation & Inflammation Reduction

Beyond microbial control, 4-Terpineol actively suppresses the production of pro-inflammatory mediators. It inhibits the release of cytokines such as TNF-α, IL-1β, IL-8, and PGE2 from activated monocytes, rapidly reducing the clinical signs of inflammation, erythema, and swelling associated with acne lesions.

4. Cosmetic Applications

NanoActive 4-TERPINEOL is a versatile, high-performance active suitable for a wide range of dermatological and personal care applications:

  • Anti-Acne & Blemish Control: Serums, spot treatments, and purifying toners.
  • Sensitive Skin & Rosacea Care: Soothing lotions and barrier-repair creams.
  • Advanced Scalp Care: Anti-dandruff shampoos and scalp-purifying treatments.
  • Intimate Care: Gentle, pH-balanced washes for microbiome control.
  • Men’s Grooming: Aftershave balms to prevent folliculitis.

5. Formulation Guidelines

PuriPharm guarantees ease of use for formulators:

  • Solubility: Readily dispersible in water and cold-processable.
  • Process: Can be added directly to the aqueous phase or at the end of the formulation process (<45°C).
  • pH Stability: Stable across a broad pH range (4.0 – 7.0).
  • Compatibility: Highly compatible with standard cosmetic ingredients, including AHA/BHAs, niacinamide, and typical rheology modifiers.

PuriPharm Co. Ltd. Innovating the Future of Active Delivery.

NanoActive DHM

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NanoActive DHM Epigenetic Youth Restorer & DNA Methylation Inhibitor

1. PRODUCT IDENTIFICATION

  • Product Name: NanoActive DHM
  • Trade Name: NanoActive DHM by PuriPharm
  • INCI Name: Water, Glycerin, Caprylic/Capric Triglyceride, Ampelopsis Grossedentata Extract, Phospholipids, Tocopheryl Acetate.
  • Botanical Source of Active: Ampelopsis grossedentata(Vine Tea)
  • Active Content: 9.5% – 10.5% (Ampelopsis Grossedentata Extract)

2. PRODUCT DESCRIPTION

NanoActive DHM represents a paradigm shift in epigenetic anti-aging. Developed by PuriPharm Co. Ltd., it is the industry’s first cosmetically viable DNA methylation inhibitor. Utilizing advanced nanoliposomal technology, highly purified Dihydromyricetin (DHM) is encapsulated in a biomimetic phospholipid bilayer. This sophisticated delivery system overcomes the inherent instability and poor skin penetration of DHM, allowing for targeted delivery to the deep epidermis and dermis, fundamentally reversing cellular aging at the genetic transcription level.

3. MECHANISM OF ACTION

Environmental stressors (UV, pollution) and intrinsic aging lead to hypermethylation of DNA, which functionally “silences” essential youth and structural genes.

  • Epigenetic Reversal: NanoActive DHM acts as a potent DNA methylation inhibitor, effectively removing age-induced methyl tags.
  • Gene Reactivation: By modulating over 10,000 methylation sites, it reactivates silenced genes associated with the Extracellular Matrix (ECM), signal transduction, and autophagy.
  • Targeted Delivery: The 50-150 nm liposomal spheres ensure enhanced transdermal absorption and a sustained-release profile, maximizing biological availability and minimizing potential irritation.

4. TECHNICAL SPECIFICATIONS

5. EFFICACY & CLINICAL DATA SUMMARY

  • Transcriptomic Upregulation: Significantly upregulates key structural genes including COL6A1 (Collagen Type VI), ITGB6, ITGA5, and VCL, restoring cellular anchorage and tissue firmness.
  • 3D Skin Equivalent Model: In a 6-week in vitrostudy utilizing 20µM DHM on mature 3D skin models, NanoActive DHM effectively reversed epidermal thinning. Epidermal thickness increased from 30µm (untreated mature control) to ~50µm, closely mirroring the baseline of young skin models (60µm). Statistical significance achieved (p = 0.00064).

6. FORMULATION GUIDELINES

NanoActive DHM is designed for ease of use in premium cosmetic formulations.

  • Recommended Usage Level: 1.0% – 5.0%
  • Incorporation Phase: Add to the aqueous phase or during the cooling phase (below 45°C) for emulsions to maintain liposomal integrity.
  • pH Compatibility: Stable within a final formulation pH range of 4.5 – 7.5.
  • Incompatibilities: Avoid high concentrations of strong ionic surfactants or extreme ethanol levels (>20%) which may disrupt the lipid bilayer.
  • Processability: Do not subject to intense, prolonged shear force (homogenization > 3000 rpm for extended periods) after incorporation.

7. TARGET APPLICATIONS

  • Premium Anti-Aging Skincare: Serums, night creams, and eye treatments targeting chronological aging and photoaging.
  • Medical Aesthetics Post-Care: Restorative formulations designed to prolong the effects of clinical treatments by maintaining epigenetic cellular health.
  • Preventative Aging: Solutions targeting millennials/Gen-Z exposed to urban pollution, stress, and lifestyle-induced epigenetic damage.

8. STORAGE & SHELF LIFE

  • Storage Conditions: Store in a cool, dry place away from direct sunlight. Recommended storage temperature: 4°C – 25°C. Do not freeze. Keep containers tightly sealed when not in use.
  • Shelf Life: 24 months from the date of manufacture under optimal storage conditions.

Disclaimer: The information provided herein is based on our current knowledge and rigorous scientific testing. It is intended for informational purposes for cosmetic professionals and formulators. It is the responsibility of the formulator to ensure the stability, safety, and regulatory compliance of the final consumer product.

PuriPharm Co. Ltd.Pioneering Epigenetic Skincare SolutionsWebsite: www.puriactives.com | Email: service@puripharm.com

NanoActive® 7-DHC THE SKIN-NATIVE PROVITAMIN D PLATFORM

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Executive Overview
Science-Backed Innovation
PuriPharmis a leading specialist in the design and manufacture of high-functional cosmetic active ingredients and advanced delivery platforms.
Our mission is to empower global B2B customers with biologically meaningful solutions that translate complex cellular science into commercially successful skincare products.
PuriPharmBrand Framework
Why 7-DHC Matters
Endogenous Relevance
7-dehydrocholesterol (7-DHC) is a skin-native precursor produced naturally in the human epidermis.
As a key intermediate in the cholesterol biosynthetic pathway, it represents a truebiomimeticapproach to skin health, aligning with the skin’s inherent chemistry.
 
The Provitamin D Pathway
Homeostatic Skin Support
Translating Science to Beauty
The Delivery Advantage
The 7-DHC Innovation Platform
Beyond Traditional Actives
NanoActive® 7-DHC represents more than an ingredient—it is abiological platformfor brands seeking the next frontier in skin resilience.
By mimicking endogenous pathways, it offers a “Biology-First” marketing angle that resonates with sophisticated, research-driven consumers.
Mechanism of Action
Evidence Hierarchy
Polished Claim Map
Formulation Guidelines
Concept Applications
Target Consumer Needs
 
The Differentiation Edge
Commercial Strategic Value
Key Takeaways
 

Puripharm works together with Huzhou Center of Industrial Biotechnology, Chinese Academy of Sciences, to build a joint laboratory

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At the beginning of 2018, PuriPharm Co., Ltd. and Huzhou Center of Industrial Biotechnology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), signed the cooperation agreement on seeking common development by jointly establishing the Puri Joint Research and Development Laboratory.Continue reading→