PuriActives® SH50

Posted on 09/27/202609/27/2026 by L, Y

PuriActives® SH50 Saccharide Hydrolysate

Advanced Sugar Science for Skin & Hair Hydration

INCI — SACCHARIDE HYDROLYSATE · CAS 8013-17-0

A science-driven report for formulators, R&D scientists, and technical marketing teams

01 · MARKET OPPORTUNITY · 市场机遇

Hydration: An Inevitable Imperative

Healthy skin and hair are, first and foremost, water-rich systems.

In skin, stratum corneum water content determines flexibility, smoothness, and barrier performance — a healthy surface holds about 20–30% water, maintained by the skin’s own hygroscopic reservoir, the Natural Moisturizing Factor (NMF). In hair, water content governs flexibility, softness, and resistance to breakage. Yet daily life works against it: low humidity, cleansing, and aging continually erode the body’s own water-holding capacity.

Consumer Demand

Soft, dewy, comfortable skin and smooth, manageable hair — every single day.

The Biological Challenge

NMF depletion, accelerated water loss, and dry, fragile fibers.

The Sugar Answer

Hydroxyl-rich molecules that capture, bind, and retain water exactly where skin and hair need it most.

Three Drivers of Water Loss

— Low humidity, wind, and climate stress accelerate surface water loss

— Surfactant cleansing washes away water-soluble NMF

— Aging reduces the skin’s own production of NMF components

Sources — Rawlings & Harding, Dermatol. Ther., 2004 · Fowler, Pract. Dermatol., 2012

02 · PRODUCT IDENTITY · 产品身份

Meet PuriActives® SH50

Saccharide Hydrolysate（糖类水解物）

INCI name	Saccharide Hydrolysate
Identifiers	CAS 8013-17-0 · EC 232-393-1
Chemical nature	A plant-derived mixture of low-molecular-weight sugars
Origin	Produced by directed hydrolysis (inversion) of food-grade natural sugars
INCI functions	Humectant · skin conditioning · skin protecting
Safety status	CIR Expert Panel — safe as used · US FDA GRAS direct food additive · Listed in China’s IECIC inventory

Not an ordinary sugar blend — a well-defined, low-molecular-weight saccharide hydrolysate, built for modern water-based formulations.

Sources — CIR safety assessment, Int. J. Toxicol., 2025 · PubChem, Saccharide Hydrolysate (CAS 8013-17-0) · IECIC 2021 · PuriPharm process documentation

03 · SKIN BIOLOGY · 皮肤生物学

Why Sugars Matter to Skin

NMF accounts for 20–30% of stratum corneum dry weight — and sugars themselves are natural NMF components.

— Hydroxyl-rich sugars capture water through extensive hydrogen bonding

— Their small molecular size keeps them active in and around corneocytes

— The skin’s own design principle: many small polar molecules locking water where it matters

Sources — Fowler, Pract. Dermatol., 2012 · Rawlings & Harding, Dermatol. Ther., 2004 · Verdier-Sévrain & Bonté, J. Cosmet. Dermatol., 2007

04 · MECHANISM OF ACTION · 作用机制

A Multi-Dimensional Hydration Mechanism

01Bind waterLow-molecular-weight sugar molecules present a dense array of hydroxyl groups, forming an extensive hydrogen-bond network with water molecules.	02Hold waterAs hygroscopic molecules, sugars build a water reservoir at the skin and hair surface, buffering fluctuations in ambient humidity.
03Reduce surface water lossA water-rich surface slows evaporation from the stratum corneum, helping skin preserve its own water content.	04Support barrier comfortHydrated corneocytes stay supple; the skin surface remains smooth, soft, and comfortable throughout the day.

Mechanistic basis drawn from carbohydrate chemistry and skin hydration research — Verdier-Sévrain & Bonté, 2007 · Fluhr et al., 2023

05 · EFFICACY — HYDRATION · 功效证据 · 保湿

Hydration & Water Retention

From isolated stratum corneum to human volunteers, saccharide systems consistently improve the skin’s ability to bind and retain water across multiple models.

A natural sugar-derived humectant complex significantly enhanced bound-water capacity within the stratum corneum and modulated its structural parameters.

In vitro Raman spectroscopy · human stratum corneum　｜　Fluhr et al., J. Biophotonics, 2023

A serum containing 7% galacto-oligosaccharides significantly improved skin water retention (Corneometer measurement, p < 0.05 vs. control base).

Randomized controlled trial · N=60 · 8 weeks　｜　Hong et al., J. Pers. Med., 2020

Ten hygroscopic humectants (common moisturizing-cream types) significantly increased water retention in treated human stratum corneum, directly quantified by thermal desorption–mass spectrometry.

Thermal desorption–mass spectrometry　｜　Gournay et al., Int. J. Cosmet. Sci., 1995

These studies evaluated saccharide systems similar to — but not identical with — PuriActives® SH50. Together they establish the class’s hydration mechanism across complementary models.

06 · EFFICACY — BARRIER · 功效证据 · 屏障

Supporting the Skin Barrier

Hydration is not only about adding water — it is about maintaining a healthier water-management environment for the skin.

Transepidermal water loss kept under control

In an 8-week randomized trial, the oligosaccharide serum group showed significantly smaller TEWL changes than the control group at weeks 4–8 (p < 0.05), with a reduced erythema index at week 8.

Hong et al., J. Pers. Med., 2020

Hydration supports barrier biology

Adequate stratum corneum water content underpins the enzymatic processes required for orderly desquamation and surface cohesion.

Rawlings & Harding, Dermatol. Ther., 2004

Supple, not tight

Humectant-saturated corneocytes stay soft, reducing the tightness and surface micro-cracking typical of dehydrated skin.

Verdier-Sévrain & Bonté, J. Cosmet. Dermatol., 2007

07 · SENSORY DIMENSION · 感官维度

Skin Comfort & Sensory Benefits

Hydration is something consumers can truly feel. Water-plasticized keratin is the physical basis of softness, bounce, and a beautiful skin feel.

Softer to the touchBound water lowers the glassy stiffness of surface keratin; skin yields softly under touch.	Smoother surfaceHydrated corneocytes lie flatter and shed more evenly, improving surface texture and light reflection.
Less tightnessA water-buffered surface eases the dry, tight feeling after cleansing and in low-humidity environments.	Comfortable after-feelSmall-molecule, water-phase humectants blend easily into light, fresh texture concepts.

In a clinical study on sensitive atopic skin, an emulsion containing gluco-oligosaccharide and collagen tripeptide improved skin condition and tolerance parameters within 4 weeks — demonstrating that oligosaccharide-based care is well suited to reactive skin.

Berardesca et al., Int. J. Cosmet. Sci., 2009

08 · FRONTIER SCIENCE · 前沿科学

The Skin Microbiome — A Prebiotic Frontier

Skin microbes feed on sugars. Choosing which sugars to offer them is becoming a formulation strategy.

Short-chain fructo-oligosaccharides sustain the growth of beneficial Staphylococcus epidermidis while inhibiting Cutibacterium acnes and Staphylococcus aureus; in a reconstructed human epidermis model, 1% scFOS tilted microbial competition toward S. epidermidis.

Selective utilization · in vitro + reconstructed epidermis　｜　Le Bourgot et al., Sci. Rep., 2022

Galacto-oligosaccharides demonstrated prebiotic potential on the skin microbiota, with diffusion properties suited to topical delivery.

Prebiotic potential · skin microbiota　｜　Petrov et al., Int. J. Cosmet. Sci., 2022

An oligosaccharide-containing serum increased microbial diversity (Shannon index) after 8 weeks and reduced S. aureus abundance, while hydration parameters improved in parallel.

Human randomized controlled trial · facial skin　｜　Hong et al., J. Pers. Med., 2020

These effects were demonstrated for specific oligosaccharide structures. As a fermentable sugar substrate of the same class, PuriActives® SH50 offers a scientifically coherent platform for microbiome-friendly formulations.

09 · BEYOND SKIN · 承前启后 · 超越皮肤

From Skin to Hair — The Same Water Physics

Hair is keratin too. The water-binding logic that works on skin transfers directly to the hair fiber.

Water is hair’s plasticizer

Bound water molecules sit between keratin chains, keeping the fiber flexible; dry hair is markedly harder and more brittle.

Robbins, Chemical and Physical Behavior of Human Hair, Springer, 2012

Humidity changes mechanical behavior

Hair’s bending and recovery behavior depends strongly on humidity — evidence that internal water content dominates hand feel and style retention.

Wortmann et al., J. Appl. Polym. Sci., 2009

Humectants buffer humidity swings

Hygroscopic actives moderate the rate at which fibers gain and lose water with ambient humidity, smoothing out moisture extremes.

Yu et al., Mater. Sci. Eng. C, 2017

10 · HAIR CARE · 护发应用

PuriActives® SH50 Hair-Care Benefits

A small-molecule humectant delivering four tangible improvements to hair feel and behavior.

Moisture balanceHygroscopic sugar molecules attract and hold water inside and on the fiber, buffering moisture loss in dry air.	Softness & supplenessWater-plasticized fibers bend without breaking — the mechanical root of soft, bouncy hair.
Smooth combingBalanced internal moisture helps cuticles lie flatter, easing combing and reducing frizz and flyaway.	Daily protectionBy moderating humidity-driven swell–shrink cycles, hydration reduces hygral fatigue damage.

Mechanistic basis: humidity-sensitive hair mechanics (Yu et al., Mater. Sci. Eng. C, 2017; Wortmann et al., J. Appl. Polym. Sci., 2009) and hair–water relations (Robbins, Springer, 2012; Kanlayavattanakul & Lourith, Springer, 2015).

11 · FOR FORMULATORS · 致配方师

Formulation Value

Water-phase addition — simple and direct

Fully water-compatible small molecules — add directly to the emulsion water phase, or to aqueous serums, mists, and shampoos. No solubilizers, no heating process.

Broad format compatibility

Leave-on and rinse-off, emulsified and purely aqueous systems, skin and hair — one INCI covers facial serums, moisturizers, sheet masks, scalp essences, shampoos, conditioners, and hair masks.

Synergy logic

Naturally pairs with glycerin and hyaluronic acid (multi-size hydration); synergizes with β-glucans, amino acids (NMF-style blends), ceramides (hydration + lipid repair), and conditioning polymers in hair-care systems.

Use levels: maximum reported concentrations — 4.6% rinse-off (US industry survey, CIR 2025); 3% leave-on (China IECIC).

Within these reported use levels, PuriActives® SH50 is assessed as safe as used (CIR, Int. J. Toxicol., 2025) and is listed in China’s IECIC inventory.

12 · APPLICATIONS · 应用场景

Application Directions

Skincare

Hydrating serums & essences — fast-absorbing water-phase hydration forming the formula’s moisture backbone.

Daily moisturizers & barrier creams — sustained surface hydration and comfort in leave-on formulas.

Sheet & sleeping masks — high-dose water delivery in intensive-care concepts.

Facial mists & toners — light, non-sticky all-day water replenishment.

Sensitive-skin lines — gentle, sugar-based hydration with a well-documented safety record.

After-sun & post-procedure care — hydration support for stressed, dehydrated skin.

Men’s care — zero-burden hydration with no occlusive greasiness.

Body lotions & hand care — everyday barrier hydration at economical use levels.

Hair & Scalp Care

Moisturizing shampoos — surface-substantive hydration that remains after rinse-off.

Conditioners & hair masks — water-plasticized softness and improved combability.

Leave-in sprays & hair serums — lasting moisture balance and frizz management.

Scalp tonics & essences — scalp hydration is the foundation of comfort.

Curly & textured hair care — keeping moisture where it is needed most.

Anti-dryness repair lines — buffering the humidity swings that drive hygral fatigue.

13 · STARTING POINTS · 开发起点

Formulation Inspiration

Water-Barrier Hydrating SerumRole of SH50: 1–3% to build a multi-layer hydration backbone, within reported use levels.Pair with: hyaluronic acid, glycerin, panthenol.Positioning: a daily hydrating serum for all skin types.	24-Hour Moisturizing CreamRole of SH50: continuous water supply in the emulsion water phase.Pair with: ceramides, squalane, shea butter.Positioning: a barrier-comfort cream for day and night.
Scalp Comfort EssenceRole of SH50: scalp hydration and fermentable-sugar care in a leave-on water-based formula.Pair with: niacinamide, caffeine, gentle soothing agents.Positioning: a light, leave-on scalp treatment.	Hydrating Repair Hair MaskRole of SH50: replenishing fiber moisture in an intensive rinse-off base.Pair with: cationic conditioners, hydrolyzed proteins, plant oils.Positioning: a weekly deep-hydration treatment.

These concepts are starting points for development discussions; suggested dosages remain within the reported cosmetic use concentrations for saccharide hydrolysate.

14 · SUMMARY · 核心总结

Why PuriActives® SH50

01　Advanced water management. A low-molecular-weight saccharide humectant system that binds water through dense hydroxyl chemistry and keeps it in the stratum corneum.

02　Barrier support. Hydration is structural: adequate water content supports desquamation, surface cohesion, and controlled water loss.

03　Consumer-perceivable comfort. Softer touch, smoother surface, less tightness — the sensory signature of hydrated skin and hair.

04　Skin + hair in one. One INCI, two categories: the same water-binding logic serves facial, body, scalp, and hair care.

05　Formulation-friendly. Simple water-phase addition, no format restrictions, globally compliant — CIR assessed safe as used, FDA GRAS background, listed in China IECIC.

What it is — a purified saccharide system　·　Why it matters — water defines skin and hair quality　·　Why choose it — simple, safe, versatile

15 · EVIDENCE BASE · 证据基础

Scientific References

[1] Johnson W Jr, Bergfeld WF, Belsito DV, et al. Safety Assessment of Anhydrogalactose, Anhydroglucitol, Anhydroxylitol, Arabinose, Psicose, Saccharide Hydrolysate, and Saccharide Isomerate as Used in Cosmetics. Int. J. Toxicol. 2025; 44(4_suppl): 93S–120S. DOI: 10.1177/10915818251384580

[2] Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatol. Ther. 2004; 17(Suppl. 1): 43–48. DOI: 10.1111/j.1396-0296.2004.04S1005.x

[3] Fowler JF Jr. Understanding the role of natural moisturizing factor in skin hydration. Pract. Dermatol. 2012; 9: 36–40.

[4] Verdier-Sévrain S, Bonté F. Skin hydration: a review on its molecular mechanisms. J. Cosmet. Dermatol. 2007; 6(2): 75–82. DOI: 10.1111/j.1473-2165.2007.00300.x

[5] Fluhr JW, Tfayli A, Darlenski R, et al. Glycerol and natural sugar-derived complex modulate differentially stratum corneum water-binding properties and structural parameters in an in vitro Raman-desorption model. J. Biophotonics 2023; 16(1): e202200201. DOI: 10.1002/jbio.202200201

[6] Gournay A, Navarro R, Mathieu J, Rivière M. Water retention of treated stratum corneum measured by a coupling method: thermal desorption–mass spectrometry. Int. J. Cosmet. Sci. 1995; 17(4): 165–172.

[7] Hong KB, et al. Changes in the diversity of human skin microbiota to cosmetic serum containing prebiotics: results from a randomized controlled trial. J. Pers. Med. 2020; 10(3): 91. DOI: 10.3390/jpm10030091

[8] Berardesca E, Abril E, Serio M, Cameli N. Effects of topical gluco-oligosaccharide and collagen tripeptide F in the treatment of sensitive atopic skin. Int. J. Cosmet. Sci. 2009; 31(4): 271–277. DOI: 10.1111/j.1468-2494.2009.00495.x

[9] Le Bourgot C, Meunier C, Gaio E, et al. Effects of short chain fructo-oligosaccharides on selected skin bacteria. Sci. Rep. 2022; 12: 9702. DOI: 10.1038/s41598-022-13093-5

[10] Petrov A, Ćorović M, Milivojević A, et al. Prebiotic effect of galacto-oligosaccharides on the skin microbiota and determination of their diffusion properties. Int. J. Cosmet. Sci. 2022; 44(3): 309–319. DOI: 10.1111/ics.12778

[11] Zeng M, Li Y, Cheng J, Wang J, Liu Q. Prebiotic oligosaccharides in skin health: benefits, mechanisms, and cosmetic applications. Antioxidants 2025; 14(6): 754. DOI: 10.3390/antiox14060754

[12] Yu Y, Yang W, Wang B, Meyers MA. Structure and mechanical behavior of human hair. Mater. Sci. Eng. C 2017; 73: 152–163. DOI: 10.1016/j.msec.2016.12.008

[13] Wortmann FJ, Stapels M, Chandra L. Humidity-dependent bending recovery and relaxation of human hair. J. Appl. Polym. Sci. 2009; 113(5): 3336–3344. DOI: 10.1002/app.30336

[14] Robbins CR. Chemical and Physical Behavior of Human Hair. 5th ed. Berlin: Springer; 2012.

[15] Kanlayavattanakul M, Lourith N. Biopolysaccharides for skin hydrating cosmetics. In: Polysaccharides. Cham: Springer; 2015. p. 1867–1892. DOI: 10.1007/978-3-319-16298-0_29

Disclaimer

This document is prepared by PuriPharm Co., Ltd. for technical communication on cosmetic ingredients only and does not constitute any drug or medical claim. Third-party literature data are cited as technical background; the cited studies evaluated saccharide systems of the same class as, but not identical with, this product. Customers should independently verify the suitability and regulatory compliance of their finished formulations. PuriActives® is a trademark of PuriPharm Co., Ltd.

PURIPHARM CO., LTD.

PuriActives® SH50

Smarter sugar science for modern beauty — skin & hair hydration, from molecule to market.

INCI — SACCHARIDE HYDROLYSATE · CAS 8013-17-0

PuriPharm Co., Ltd. — Technical Product Report

PuriActives® SupraFerulix™

Posted on 08/19/202608/19/2026 by L, Y

Ferulic Acid, Reimagined:Meet PuriActives® SupraFerulix™

A supramolecular ferulic acid active for antioxidant, brightening & skin-comfort formulations.

Antioxidant protection is no longer a premium add-on — it is the new baseline.

Skincare has entered the antioxidant era. Consumers increasingly expect daily defense against oxidative stress from UV exposure, urban pollution and the visible signs of photoaging — while also asking for brighter-looking skin, sensitive-skin compatibility and microbiome-friendly care. The challenge for formulators is no longer whether to use an antioxidant, but how to deliver antioxidant performance with greater formulation flexibility and a more elegant skin experience.

01 · THE HERO MOLECULE

Why Ferulic Acid Still Matters

A classic antioxidant with enduring relevance in modern dermocosmetic and prestige skincare.

Ferulic acid · 4-hydroxy-3-methoxycinnamic acid · C10H10O4

Ferulic acid is a well-recognized plant-derived phenolic antioxidant valued for oxidative stress protection, photoaging care and radiance support. It is also known for complementing vitamin C / E antioxidant systems — one reason it remains a familiar ingredient in prestige antioxidant formulas.

Antioxidant profileHelps protect skin from environmental oxidative stress.	Photoaging careSupports skin exposed to UV and environmental stress.
Radiance supportHelps improve the look of dull, tired-looking skin.	Antioxidant synergyKnown for complementing vitamin C / E systems.

02 · THE FORMULATION PARADOX

Powerful, but Demanding

Conventional ferulic acid can make high-performance formulation unnecessarily difficult.

The molecule is compelling. The formulation experience can be less so. Conventional ferulic acid systems may face stability concerns, compatibility limitations, solubility and dispersibility challenges, sensory trade-offs and restricted formulation flexibility. Oxidation-driven color change, formula-environment sensitivity, uneven incorporation, and odor or color impact can all compromise the elegance of a finished product.

The market needs ferulic acid that is easier to formulate — and kinder to skin.

03 · THE PURIPHARM SOLUTION

Not Just an Ingredient. A Smart Active System.

Supramolecular association — designed, not simply mixed.

PuriActives® SupraFerulix™ · supramolecular ferulic acid active

PuriActives® SupraFerulix™ combines ferulic acid with zinc glycinate, xyloglucan and alpha-glucan oligosaccharide in a supramolecular design engineered for formulation flexibility and skin comfort.

FA	Ferulic AcidAntioxidant, anti-photoaging and radiance support — the hero of the system.

ZG	Zinc GlycinateSkin comfort, oil-prone skin support and soothing positioning.

XG	XyloglucanBio-polymer film-forming, barrier support and a hydration-friendly skin feel.

AGO	Alpha-Glucan OligosaccharidePrebiotic-inspired microbiome balance and sensitive-skin care positioning.

04 · SUPRAMOLECULAR DESIGN

A Protective Matrix, Built Around the Active

Four components work together through non-covalent supramolecular interactions.

Rather than treating ferulic acid as a stand-alone molecule, SupraFerulix™ places it within a supportive matrix. The design concept is intended to create a more formulation-friendly environment around the active, while integrating comfort-, barrier- and microbiome-oriented components into the same system.

Non-Covalent AssociationComponents work together through supramolecular interactions, not simple mixing.	A Protective EnvironmentThe supportive matrix positions ferulic acid for more formulation-friendly use.
Comfort-Oriented DesignBuilt for gentle, high-performance daily skincare concepts.	One Synergistic SystemAntioxidant performance is paired with comfort, barrier and microbiome positioning.

05 · FOUR PATHS TO BETTER SKIN

Performance That Goes Beyond Antioxidant Defense

A multi-dimensional skincare story for modern daily-care concepts.

Antioxidant DefenseHelps protect skin from environmental oxidative stress — UV, pollution and daily aggressors.	Barrier SupportA bio-polymer film helps support the moisture barrier and a hydrated skin feel.
Skin ComfortSoothing-oriented design for daily, gentle, high-performance use.	Microbiome BalancePrebiotic-inspired care designed to respect skin’s natural flora.

Xyloglucan supports a smooth, cushiony, hydration-friendly sensory concept.

06 · COMPONENT SPOTLIGHT

Four Roles, One Formula Story

Ferulic Acid is the hero antioxidant: it supports environmental stress defense, radiance and visible photoaging care, while complementing vitamin C / E systems.

Zinc Glycinate brings a mild zinc–amino acid complex into the system, supporting skin-comfort, soothing, sensitive-skin and oil-prone skin positioning.

Xyloglucan is the bio-polymer element. It forms a soft, breathable film, supports moisture retention and barrier function, and contributes to an elegant hydrated skin feel.

Alpha-Glucan Oligosaccharide adds a prebiotic-inspired angle, supporting microbiome-friendly, balance-focused and gentle daily-care concepts.

07 · FORMULATION ADVANTAGES

Designed to Formulate Beautifully

One active system, compatible with a wide range of dosage forms.

Formulation science in practice · illustration from the product presentation

Better CompatibilityImproved formulation compatibility versus conventional ferulic acid systems.	Flexible Across SystemsSuitable for both water-based and emulsion-based formulations.
Elegant Skin FeelA smooth, comfortable sensory profile for prestige positioning.	Clean-Beauty ReadyFits modern clean and minimalist formula concepts.
Sensitive-Skin ConceptsComfort-oriented design for gentle, sensitive-skin positioning.	Dosage-Form FreedomSerums · essences · lotions · creams · masks · ampoules.

08 · READY-TO-DEVELOP CONCEPTS

Seven Product Stories From One Active System

01	Antioxidant Brightening SerumA daily radiance-and-defense hero serum.

02	Urban Defense EssenceLightweight daily shield against pollution stress.

03	Sensitive-Skin Radiance AmpouleGentle glow in an intensive, comfort-first format.

04	Anti-Photoaging CreamDaily defense against visible signs of photoaging.

05	Post-Sun Repair LotionAfter-sun comfort and antioxidant care.

06	Oil-Prone Antioxidant GelLight, balancing antioxidant care for oil-prone skin.

07	Microbiome-Friendly Daily CareEveryday moisturizer supporting skin’s natural balance.

Antioxidant brightening serum · concept visual

09 · WHY UPGRADE

Conventional Ferulic Acid vs. SupraFerulix™

Dimension	Conventional Ferulic Acid	PuriActives® SupraFerulix™
System design	Single antioxidant molecule	Supramolecular active system
Formulation	Limited flexibility; stability and color-change concerns	Formulation-friendly design for modern systems
Care concept	Active-only approach	Antioxidant + comfort + barrier + microbiome concept
Positioning	Classic antioxidant	Modern, skin-comfort-oriented active system

SupraFerulix™ advantages reflect design intent; detailed performance should be confirmed against PuriPharm technical data.

10 · CLAIMS & SUPPORT

A Communication Platform Built for Cosmetic Formulation

Claim DirectionHelps protect skin from oxidative stress.	Claim DirectionSupports brighter-looking skin.
Claim DirectionHelps improve dull-looking complexion.	Claim DirectionSupports skin comfort.
Claim DirectionMicrobiome-friendly antioxidant system.	Claim DirectionDesigned for sensitive-skin-compatible antioxidant formulations.

Final claims should be validated against the regulatory requirements of each target market.

Documentation and technical support accompany the product.

Every batch is backed by complete documentation: TDS, COA, SDS, product specification, formulation guidance, regulatory support for target markets and customized technical communication on request.

Ferulic acid, reimagined as a modern supramolecular active system. PuriActives® SupraFerulix™ turns a classic antioxidant into a high-performance, skin-comfort-oriented system for antioxidant, brightening and gentle daily-care formulations.

ANTIOXIDANT DEFENSE · SKIN COMFORT · FORMULATION FREEDOM

PuriPharm Co., Ltd.

www.puriactives.comservice@puripharm.com · +86-572-2745768Building 6, No. 1366 Hongfeng Road, Huzhou, Zhejiang, China

For cosmetic formulation use only. No drug claims intended.

PuriActives®SupraSalix A Supramolecular Salicylic Acid System for Clearer,Calmer and Better-Balanced Skin

Posted on 08/02/202608/02/2026 by L, Y

THE NEW STANDARD IN CLARIFYING CARE

THE SALICYLIC ACID PARADOX

BEYOND CONVENTIONAL FREE SALICYLIC ACID

INTRODUCING PURIACTIVES® SUPRASALIX

WHAT “SUPRAMOLECULAR” MEANS

FOUR COMPONENTS, ONE INTEGRATED SYSTEM

SALICYLIC ACID: PRECISION CLARIFICATION

ZINC GLYCINATE: ANTIOXIDANT & COMFORT

XYLOGLUCAN: A SOFT PROTECTIVE INTERFACE

ALPHA-GLUCAN OLIGOSACCHARIDE: MICROBIOME CARE

THE 4D SUPRASALIX PLATFORM

A MULTI-LEVEL SKIN-BALANCE STRATEGY

DESIGNED FOR BETTER FORMULATION FREEDOM

EVIDENCE ARCHITECTURE

PUBLISHED SALICYLIC ACID EVIDENCE: CONTEXT

PUBLISHED ZINC-GLYCINE EVIDENCE

FROM FACIAL CLARITY TO SCALP BALANCE

FORMULATION FORMATS

PRODUCT-SPECIFIC VALIDATION ROADMAP

RESPONSIBLE CLAIMS & REGULATORY AWARENESS

WHY PURIACTIVES® SUPRASALIX

Product Data Sheet: NanoActive® Bakuchiol

Posted on 07/16/202607/16/2026 by L, Y

1. Product Description

NanoActive® Bakuchiol is a premium, biomimetic active ingredient concept featuring highly concentrated Bakuchiol encapsulated within a proprietary sub-micron lipid nanocarrier system. Derived from the seeds of Psoralea corylifolia, this retinol-like botanical active is engineered for enhanced stability, superior aqueous dispersion, and high tolerability in modern anti-aging, sensitive-skin, and blemish-care applications.

2. INCI Name & Composition

INCI Name: Water (Aqua), Glycerin, Bakuchiol, Phospholipids, Caprylic/Capric Triglyceride.
Source: 100% Plant-derived active (Bakuchiol).
Solubility: Highly miscible in water-based phases; easily incorporated into aqueous serums, hydrogels, and O/W emulsions.

3. Chemical-Physical & Microbiological Specifications

Designed to meet stringent global quality standards, ensuring optimal safety and formulation elegance.

4. Key Technical Advantages

Retinol-like Efficacy: Acts on the same biological pathways as retinol (e.g., retinoic acid receptor signaling) without the associated irritation or light sensitivity.
Aqueous Transparency: The glycerin-water nanocarrier base allows the formulation of crystal-clear serums without the need for harsh solubilizers.
Advanced Nano-Delivery: NanoActive® encapsulation ensures controlled, sustained delivery of the 10% active payload deep into the epidermal layers.
Skin Barrier Support: Integrated phospholipid bilayer mimics skin lipids, reinforcing the barrier function while delivering the active.

5. Clinical Evidence Highlights

Anti-Aging: Supports significant reduction in the appearance of fine lines and wrinkles.
Firmness & Elasticity: Promotes the appearance of a firmer skin texture by supporting collagen I, III, and IV expression.
Soothing & Inflammation: Effectively supports the reduction of visible redness and inflammation in sensitive and acne-prone skin.
Pigmentation: Helps achieve a more uniform skin tone and brightness through the modulation of pigment-related pathways.

6. Formulation Guidelines

Recommended Use Level: 1.0% – 5.0% (delivering 0.1% – 0.5% pure Bakuchiol to the final product).
Processing:
Phase: Add into the water phase or during the final cool-down phase (below 45°C) to maintain the integrity of the nanocarrier system.
pH Stability: Optimal range 4.5 – 7.0.
Antioxidant Protection: Since the delivery system relies on an aqueous/glycerin base, adding complementary antioxidants (e.g., Vitamin E, stabilized Vitamin C) to the final formulation is highly recommended to protect the active from long-term oxidation.
Chelating Agents: EDTA or naturally derived chelators (e.g., Sodium Phytate) are recommended to ensure formula stability.

7. Safety & Regulatory

Safety Profile: High tolerability demonstrated in clinical use; suitable for sensitive skin. Non-phototoxic.
Claims: Supports acne-prone skin care, helps improve the appearance of blemish-prone skin, promotes clearer-looking skin, anti-aging, skin soothing.
Storage: Store in a cool, dry place, protected from direct light and heat. Keep container tightly closed.

8. Applications

Premium Anti-Aging Clear Serums & Hydrogels
Sensitive Skin Repair Formulations
Blemish-Care & Acne-Prone Skin Treatments
Brightening & Uneven Tone Correctors
Daytime Protective Skincare (Non-light-sensitizing)

Disclaimer: This document is for informational purposes for professional cosmetic formulators. The claims presented are cosmetic in nature and should be substantiated by final product testing.

NanoActive®Bakuchiol

Posted on 07/07/202607/07/2026 by L, Y

A Gentle Retinol-Like Active Powered by Nano-Delivery Technology

Executive Summary

NanoActive® Bakuchiol is a nano-delivery cosmetic active combining the well-known retinol-like benefits of bakuchiol with PuriPharm’s advanced NanoActive® delivery technology.

Designed for modern anti-aging, soothing, brightening, and acne-prone skin formulations — supporting better dispersion, formulation elegance, and enhanced product differentiation.

Market Background: Demand for Retinol Alternatives

Why Bakuchiol: Natural-Origin, Retinol-Like, Gentle

Product Identity: NanoActive® Bakuchiol

Bakuchiol Science Overview

Retinol-Like Gene Expression Mechanism

Collagen I / III / IV and ECM Support

DEJ Support and Skin Firmness Concept

Hydration Support: AQP3 and HA Pathway

Clinical Anti-Aging Evidence

Comparison with Retinol: Efficacy and Tolerance

Antioxidant Mechanism and Lipid Protection

Soothing and Anti-Inflammatory Positioning

Acne-Prone Skin Application

Brightening / Uneven Tone Support

Why Nano-Delivery Matters for Bakuchiol

NanoActive® Technology Advantages

Formulation Guidelines

Application Concepts

Competitive Advantages for Cosmetic Brands

Safety, Regulatory & Claim Language

NANOACTIVE ENOXOLONE PuriActives Core Molecule x NanoActive Delivery

Posted on 06/15/202606/15/2026 by L, Y

PuriPharm: Dual Pillars of Innovation

Two Core Innovation Pillars

PuriActives: Enoxolone from Licorice Root

NanoActive NanoCarrier: Delivery Architecture

Application Challenges: Enoxolone Limitations

NanoActive System Solution

NanoActive Enoxolone = PuriActives Molecule + NanoActive Technology

Through nano-encapsulation, insoluble crystalline powder becomes a clear, transparent, stable bioactive liquid. We deliver precision-calculated efficacy.

NanoActive Parameters: Size Advantage

Product Technical Specifications

NanoActive Drives Deep Penetration

Multi-dimensional Efficacy

Anti-inflammatory Power: TSLP Inhibition

Clinical Evidence: Atopic Dermatitis Relief

NanoActive Antioxidant Defense Matrix

11β-HSD1 Inhibition: Correcting Steroid Skin

Antimicrobial Activity

Skin Barrier Repair & Soothing

Formulation Application Guide

PuriActives® SupraSalix Supramolecular Salicylic Acid

Posted on 06/13/202606/13/2026 by L, Y

Technical Dossier | PuriPharm Co. Ltd. —— A Breakthrough 3-in-1 Targeted Solution: Sebum Control • Barrier Repair • Microbiome Balance

1. Product Overview

Traditional Salicylic Acid (SA) is highly efficacious in anti-acne and sebum control treatments. However, its free-acid form is notoriously associated with adverse effects, including severe irritation, flaking, and disruption of the skin barrier. To address this persistent industry challenge, PuriPharm Co. Ltd. has engineered PuriActives® SupraSalix (Supramolecular Salicylic Acid), specifically designed for modern sensitive skin and compromised complexions.

Powered by cutting-edge supramolecular self-assembly technology, PuriActives® SupraSalix utilizes a core of Salicylic Acid and Zinc Amino Acid. It innovatively integrates the biomimetic repair network of Xyloglucan and the prebiotic engine of α-Glucan Oligosaccharide.

This active ingredient shatters the traditional paradigm that “anti-acne equals barrier damage.” By achieving a 4D synergistic effect—sustained-release desensitization, comedolytic sebum control, biomimetic repair, and microbiome balance—it stands as a next-generation, ultra-mild anti-acne active formulated for sensitive skin, acne vulgaris, and seborrheic dermatitis.

2. Core Components & Mechanism of Action

The exceptional efficacy of PuriActives® SupraSalix originates from its meticulously designed matrix of four core components:

2.1 The Core Anti-Acne Engine: Salicylic Acid & Zinc Amino Acid

A supramolecular network cleverly conjugates Salicylic Acid with Zinc Amino Acid (primarily Zinc Glycinate) to achieve “reduced toxicity, enhanced efficacy” alongside kinetic sustained release.

Salicylic Acid: A lipophilic BHA that penetrates deep into hair follicles to dissolve keratin plugs and sebum, exerting potent comedolytic action. Simultaneously, it inhibits COX enzyme activity to block the production of pro-inflammatory mediators like prostaglandins.
Zinc Ion: An essential trace element. It inhibits 5α-reductase activity, significantly reducing sebum hypersecretion at the source. It also disrupts pathogenic biofilms for broad-spectrum antimicrobial action while accelerating wound healing and tissue remodeling.
Amino Acid (e.g., Glycine): The smallest amino acid. It not only acts as a carrier to enhance Zinc’s skin penetration but is also a critical component of the Natural Moisturizing Factor (NMF) and collagen, effectively soothing localized dryness caused by acid peeling.

2.2 The Invisible Biomimetic Barrier: Xyloglucan

A natural polysaccharide extracted from Tamarind seeds, widely recognized in pharmaceutical applications for treating eczema, dermatitis, and psoriasis.

“Second Skin” Effect: Exhibits outstanding film-forming properties, creating a breathable, invisible biomimetic shield on the skin surface to defend against external aggressors (e.g., PM2.5, allergens).
Deep Hydration & Repair: Significantly reduces Transepidermal Water Loss (TEWL), providing a moist healing microenvironment for a compromised stratum corneum. It synergizes with amino acids to accelerate barrier repair and diminish erythema (redness) and acne marks.

2.3 The Microbiome Modulator: α-Glucan Oligosaccharide

A highly active, plant-derived prebiotic.

Targeted Feeding: Selectively promotes the proliferation of beneficial skin flora (e.g., Staphylococcus epidermidis) while remaining indigestible to pathogens (e.g., Cutibacterium acnes, Malassezia).
Competitive Inhibition: By robustly cultivating beneficial bacteria to occupy the ecological niche, it competitively inhibits the microorganisms responsible for acne and seborrheic dermatitis, cutting off the root cause of recurrent breakouts from an ecological standpoint.

3. 4D Synergy Matrix

PuriActives® SupraSalix is not a simple physical blend. Through PuriPharm’s supramolecular technology, it establishes a 1+1+1>3 synergistic network:

1D Clear & Control: SA pore unclogging + Zinc’s active sebaceous inhibition. A dual-action approach to drastically improve oily skin and congested pores.
2D Targeted Anti-inflammatory: Zinc (inhibiting the upstream NF-kB pathway) combined with SA (inhibiting the downstream COX pathway). Delivers rapid erythema reduction and soothes inflamed papules.
3D Biomimetic Repair: Xyloglucan’s physical film-forming + Amino acid’s biochemical hydration. Perfectly neutralizes the harsh peeling effects of acids, enabling simultaneous “Clear & Repair.”
4D Microbiome Balance: α-Glucan Oligosaccharide reconstructs the microbial barrier, complementing the antimicrobial properties of Zn and SA. It systematically improves acne-prone and reactive skin profiles, preventing future relapses.

4. Core Advantages vs. Benchmark

5. Applications & Formulation Guidelines

PuriActives® SupraSalix demonstrates exceptional compatibility and solubility, making it highly versatile for various cosmetic formats including toners, serums, emulsions, gels, and wash-off products.

Primary Application Scenarios:

Professional Acne/Comedone Care: Anti-acne serums, spot treatment gels, chemical peel solutions (highly recommended for sensitive skin peeling).
Sebum & Pore Management: Pore-refining toners, mattifying/balancing emulsions, deep-cleansing mud masks.
Seborrheic Dermatitis & Scalp Care: Anti-dandruff shampoos, scalp oil-control serums, scalp microbiome treatments.
SOS Redness & Repair Care: Post-extraction soothing treatments, anti-inflammatory products for barrier-compromised phases.

Formulation Guidelines:

Appearance: (Please refer to the actual product COA)
Solubility: Excellent water solubility; easily incorporated into the aqueous phase.
Recommended Dosage: 1.0% – 5.0% (Depending on specific product claims and efficacy substantiation).
Optimal pH Range: 4.0 – 6.5 (A mildly acidic environment favors the stability of the supramolecular network and SA activity. Strongly alkaline environments should be avoided).
Compatibility: Pairs excellently with active ingredients such as Niacinamide, Hyaluronic Acid, and Ceramides. Note: Avoid prolonged co-existence with high concentrations of strong metal chelating agents (e.g., EDTA) in the same system to prevent competitive disruption of the Zinc complex structure.

Copyright Statement: PuriActives® is a registered trademark of PuriPharm Co. Ltd. The information provided in this document is based on current scientific research and in vitro / in vivo testing, intended solely as a reference for formulators and R&D professionals.