PURIACTIVES® PAD

PURIPHARM CO. LTD. & PURIACTIVES® PLATFORM

PuriPharm Co. Ltd. is a leading supplier of high-purity functional cosmetic actives, specializing in nano-encapsulation and advanced delivery systems for the global beauty industry.

The PuriActives® platform represents a portfolio of science-backed, formulation-friendly active ingredients designed for modern skin and scalp care formulations.

Each ingredient in the PuriActives® portfolio is selected and optimized for:

Demonstrated efficacy through scientific literature and in-house validation
Optimal formulation compatibility across a broad range of cosmetic product types
Regulatory compliance for North American, European, and Asian markets
Supply reliability and consistent batch-to-batch quality

PRODUCT SNAPSHOT

WHY POTASSIUM AZELOYL DIGLYCINATE?

Azelaic acid is a well-recognized cosmetic ingredient with multiple skin benefits. However, its practical use in cosmetic formulations has been limited by poor water solubility, low pH requirements, and skin tolerability concerns.

Potassium azeloyl diglycinate (PAD) was developed as a water-soluble derivative that retains the beneficial properties of azelaic acid while overcoming its formulation limitations.

FROM AZELAIC ACID TO A FORMULATION-FRIENDLY DERIVATIVE

Side-by-side comparison of key properties

TECHNICAL PROFILE & QUALITY SPECIFICATIONS

MARKET NEED

Oily, Blemish-Prone, Uneven-Tone & Sensitive Skin

Global consumers increasingly seek multifunctional, gentle solutions for complex skin concerns. PuriActives® PAD addresses all of these needs in a single molecule.

MECHANISM OVERVIEW: MULTI-PATHWAY SKIN BALANCE

PuriActives® PAD works through five complementary pathways for comprehensive skin, scalp, and hair benefits:

Brightening Mechanism: Tyrosinase / Melanin Pathway

Tyrosinase — The Rate-Limiting Enzyme

Tyrosinase catalyzes the conversion of tyrosine to melanin pigments in melanocytes. It is the key regulatory enzyme in melanin synthesis, making it a primary target for skin-brightening actives.

PAD Mechanism of Action

PuriActives® PAD has been reported to inhibit tyrosinase activity, helping to reduce melanin production and supporting a brighter, more even-looking skin tone.

Key Pathway Cascade

PAD → Tyrosinase Inhibition → Reduced Melanin Synthesis → Brighter Skin Appearance

Clinical Relevance

Tyrosinase inhibitors are widely used in cosmetic brightening products. PAD offers a water-soluble, well-tolerated alternative for formulators seeking brightening efficacy without the formulation challenges of azelaic acid.

Uneven Tone and Dark Spot Care

Dark spots and uneven skin tone result from localized melanin overproduction, often triggered by UV exposure, hormonal changes, or post-inflammatory responses. PuriActives® PAD helps address this through its tyrosinase-inhibition-related activity, supporting a more uniform-looking complexion over continued use.

Sebum Balance Mechanism

Blemish-Prone Skin Care Positioning

Excess sebum, inflammation, and blemish formation are interconnected concerns. PuriActives® PAD’s dual action — sebum balance support plus anti-inflammatory properties — makes it well-suited for blemish-prone skin care formulations.

Redness-Prone and Sensitive-Skin Comfort

Redness-prone skin is often associated with elevated inflammatory mediators, including IL-1α (interleukin-1 alpha), a key pro-inflammatory cytokine. PuriActives® PAD has been reported to help reduce IL-1α release, providing anti-inflammatory support that soothes the appearance of redness. Combined with glycine’s skin-conditioning properties and a neutral pH of 6.5–7.5, PAD offers excellent tolerance for sensitive skin.

Hydration and Elasticity Support

The glycine moiety in PuriActives® PAD contributes humectant and skin-conditioning properties. Glycine is a naturally occurring amino acid that helps support skin moisture retention, elasticity, and suppleness — complementing brightening and sebum-balancing benefits to create a well-rounded multifunctional active.

Scalp Care Opportunity

Scalp health is increasingly recognized as the foundation of healthy-looking hair. Oily scalp, discomfort, and imbalance are common concerns. PuriActives® PAD’s sebum-regulating and anti-inflammatory properties translate effectively to scalp care, offering brands a science-backed active for this emerging category.