PURIPHARM CO. LTD. · INGREDIENT SCIENCE PLATFORM
NanoActive™ BatyCer™
Biomimetic Skin Barrier Lipid Platform
Powered by PURISOME® Liposome Delivery Technology
INCI NAME — BATYL ALCOHOL
02 · BARRIER SCIENCE
The New Era of Skin Barrier Science
| Technology generation | Core direction |
|---|---|
| Traditional moisturization | Surface hydration |
| Occlusive barrier technology | Reduction of surface water loss |
| Ceramide-based lipid repair | Replenishment of essential barrier lipids |
| Biomimetic lipid reconstruction | Restoration of skin-like lipid organization |
| Nano-delivery lipid platform | Nanoscale delivery of ordered biomimetic lipid systems |
Each generation of barrier care has moved closer to the skin’s own biology — from surface hydration toward the restoration of its native lipid organization.
NanoActive™ BatyCer™ embodies this progression: physiological lipids, engineered into an ordered architecture, delivered at the nanoscale.
“The future of barrier care is not only hydration — it is lipid architecture restoration.”
03 · PRODUCT OVERVIEW
NanoActive™ BatyCer™
Advanced Skin Barrier Lipid Platform
A multifunctional lipid delivery system that reassembles the skin’s native barrier lipids into a single, biomimetic stratum corneum architecture.
INTEGRATED LIPID SYSTEM
| 01 | Batyl Alcohol — signature functional lipid |
| 02 | Ceramide NP — essential barrier lipid |
| 03 | Cholesterol — membrane stabilizer |
| 04 | Phospholipids — vesicle-forming carriers |
| 05 | Stearic Acid — physiological fatty acid |
04 · THE SIGNATURE LIPID
Batyl Alcohol — The Signature Functional Lipid
INCI NAME
Batyl Alcohol
CHEMICAL IDENTITY
Glyceryl Octadecyl Ether (1-O-octadecyl glycerol)
STRUCTURAL CHARACTERISTICS
| 01 | C18 alkyl chain — long-chain lipid affinity |
| 02 | Glycerol ether backbone — high chemical stability |
| 03 | Amphiphilic lipid structure — membrane compatibility |
“Batyl Alcohol bridges conventional emollient technology and biomimetic lipid engineering.”
05 · SCIENTIFIC RATIONALE
Why Batyl Alcohol?
| Scientific feature | Significance |
|---|---|
| 01 Lipid membrane compatibility | An amphiphilic alkylglycerol that partitions readily into lipid membranes and integrates with bilayer structures. |
| 02 Interaction with stratum corneum lipid domains | Its C18 chain aligns with the intercellular lipid matrix, engaging the skin’s native barrier domains. |
| 03 Support of ordered lipid organization | Promotes the formation of ordered lamellar phases — the structural basis of a competent barrier. |
| 04 Compatibility with lipid delivery systems | Readily incorporated into phospholipid vesicles, enabling stable, nano-enabled delivery formats. |
REFERENCE SCIENTIFIC FINDINGS
Alkylglycerol derivatives have demonstrated effects on:
| 01 | — TEWL reduction |
| 02 | — Stratum corneum lipid organization |
| 03 | — Barrier modulation |
Bernal-Chávez SA et al. Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators. Molecules. 2017;22(1):185.
06 · SKIN PHYSIOLOGY
Skin Barrier Lipid Architecture
| Structure | Description |
|---|---|
| Corneocytes | Flattened, protein-rich cells forming the structural “bricks” of the stratum corneum |
| Intercellular lipid matrix | Lamellar assemblies of Ceramide NP, cholesterol and free fatty acids — the true barrier to water loss |
| Lamellar organization | Ordered lipid layering governs water retention, barrier integrity, resilience and environmental protection |
“The stratum corneum functions as a highly organized lipid membrane system.”
07 · THE ESSENTIAL BARRIER LIPID
Ceramide NP
The Essential Barrier Lipid
Ceramides constitute roughly half of the stratum corneum lipid mass. Among them, Ceramide NP is a dominant species in healthy human skin — and one of the first to decline when the barrier is compromised.
| Core function | Physiological significance |
|---|---|
| Water retention | Forms the hydrophobic lamellar phases that limit transepidermal water loss. |
| Lamellar organization | Drives the stacking of lipids into long-range ordered lamellar structures. |
| Barrier cohesion | Cements corneocytes into a cohesive, mechanically resilient barrier. |
“Restoring ceramide organization is a fundamental strategy for improving barrier performance.”
08 · PHYSIOLOGICAL LIPID BALANCE
Ceramide NP + Cholesterol + Fatty Acid Synergy
Balanced physiological lipid mixtures accelerate barrier recovery — Ceramide NP enriched systems restore barrier recovery, SC hydration and lipid organization.
09 · THE INNOVATION
Batyl Alcohol Reinforced Lipid Matrix
| 01 | Batyl Alcohol: The structural lipid enhancer enters the platform. |
| 02 | Improves lipid compatibility: Harmonizes unlike lipid species within one matrix. |
| 03 | Supports membrane organization: Reinforces ordered packing across lipid domains. |
| 04 | Enhances biomimetic lipid assembly: A reinforced matrix, closer to the skin’s own architecture. |
“Batyl Alcohol functions as a structural lipid enhancer within the barrier lipid platform.”
The result: a lipid matrix with greater coherence, stability and physiological resemblance than ceramide systems alone.
10 · DELIVERY TECHNOLOGY
PURISOME® Nanoliposome Technology
An advanced phospholipid-based nanocarrier that wraps the BatyCer™ lipid complex in a skin-affine bilayer envelope.
| 01 | Lipid protection — shields sensitive lipids from oxidation and degradation |
| 02 | Improved dispersion — uniform nanoscale distribution throughout the formula |
| 03 | Enhanced formulation flexibility — easy incorporation across emulsion systems |
| 04 | Controlled lipid delivery — targeted deposition of barrier lipids at the skin surface |
11 · MOLECULAR ARCHITECTURE
Inside the NanoActive™ BatyCer™ Vesicle
| Architecture | Function |
|---|---|
| Outer phospholipid bilayer | Skin-affine vesicle envelope |
| Cholesterol stabilization | Membrane cohesion and integrity |
| Batyl Alcohol integration | Structural lipid enhancement |
| Ceramide NP lipid matrix | Biomimetic barrier core |
12 · MECHANISM OF ACTION
From Application to Barrier Performance
| 01 | Application |
| 02 | NanoActive™ BatyCer™ deposition |
| 03 | Lipid integration |
| 04 | Barrier lipid organization |
| 05 | Reduced moisture loss |
| 06 | Improved skin comfort |
Each vesicle carries a complete barrier-lipid repertoire; upon deposition, the lipids merge with the intercellular matrix and re-establish ordered lamellar organization.
13 · BARRIER REINFORCEMENT BENEFITS
Measurable Barrier Performance
| 01 | Supports skin barrier recovery: Ceramide NP enriched lipid systems are documented to restore barrier recovery. |
| 02 | Improves hydration retention: Ordered lamellar lipids reduce TEWL and sustain stratum corneum hydration. |
| 03 | Enhances skin smoothness: A restored lipid matrix refines surface texture and tactile quality. |
| 04 | Strengthens lipid resilience: Alkylglycerol-supported lipid organization reinforces barrier modulation. |
14 · HYDRATION SCIENCE
Hydration & Moisture Retention
THE PHYSIOLOGICAL LOGIC
Hydration is governed less by how much water a formula contains than by how well the barrier retains it. By rebuilding ordered lamellar lipids, NanoActive™ BatyCer™ addresses moisture loss at its structural origin.
TEWL — transepidermal water loss, the reference metric for barrier integrity.
15 · SENSITIVE SKIN
Sensitive Skin & Environmental Stress Support
| BARRIER DISRUPTION FACTORS | NANOACTIVE™ BATYCER™ SUPPORTS |
|---|---|
| Cleansing stress — Surfactants strip intercellular lipids | Lipid balance — Replenishes the physiological lipid ratio |
| Environmental exposure — Pollution and UV challenge barrier lipids | Barrier resilience — Reinforces lipid organization under stress |
| Dry climate — Low humidity accelerates water loss | Skin comfort — Reduces tightness associated with barrier disruption |
Barrier-compromised and sensitive skin states share a common origin: depleted and disorganized stratum corneum lipids. Lipid replenishment is the physiological counter-strategy.
16 · BEYOND SKIN
Advanced Hair Lipid Science
The hair fiber, like the skin barrier, depends on lipid organization. Its protective cuticle is coated in covalently bound surface lipids that chemical and thermal stress progressively remove.
CUTICLE LIPID REPLENISHMENT
NanoActive™ BatyCer™ deposits biomimetic lipids along the fiber surface, helping to re-lubricate lifted cuticle scales and restore a smooth, coherent surface.
17 · HAIRCARE APPLICATIONS
Lipid Science for Haircare Formulas
| Application | Positioning |
|---|---|
| Premium conditioners | Daily lipid replenishment in rinse-off systems |
| Hair masks | Intensive lipid restoration for damaged fiber |
| Leave-in treatments | Persistent surface lipid film for daily defense |
| Scalp barrier products | Extending barrier lipid science to the scalp |
CONSUMER-VISIBLE BENEFITS
| 01 | Improved smoothness |
| 02 | Enhanced shine |
| 03 | Better manageability |
Surface lipid replenishment translates directly into sensory properties that consumers can feel and see.
18 · FOR FORMULATORS
Formulation Advantages
| Advantage | Description |
|---|---|
| 01 Lipid system compatibility | Integrates smoothly with oils, esters, ceramide systems and phospholipid phases. |
| 02 Easy incorporation into emulsions | Pre-dispersed nanoliposome form — no high-shear solubilization required. |
| 03 Premium skincare concept fit | Biomimetic barrier story aligned with dermo-cosmetic positioning. |
| 04 Multifunctional formulations | One platform spanning facial, body, hair and scalp applications. |
“A biomimetic lipid platform that formulates like a modern active — and performs like skin’s own biology.”
19 · APPLICATION OPPORTUNITIES
One Platform, Three Categories
| Facial Care | Body Care | Hair Care |
|---|---|---|
| Barrier creamsAnti-aging moisturizersSensitive skin products | Dry skin careBody emulsionsIntensive lipid balms | ConditionersHair masksScalp care |
| Core territory: daily barrier maintenance and recovery for the face | Large-surface barrier support for dry and very dry body skin | Cuticle lipid replenishment from fiber surface to scalp barrier |
20 · SCIENTIFIC EVIDENCE LANDSCAPE
Built on Established Science
| Evidence stream | Scientific foundation |
|---|---|
| Batyl Alcohol | Alkylglycerols documented for lipid organization, TEWL reduction and barrier modulation. |
| Ceramide NP | Physiological ceramide species at the center of barrier restoration research. |
| Liposomes | Decades of evidence for phospholipid vesicles in advanced topical delivery. |
SUPPORTING LITERATURE DOMAINS
| 01 | — Stratum corneum lipid organization and lamellar phase behavior |
| 02 | — Ceramide / cholesterol / free fatty acid systems and barrier recovery |
| 03 | — Liposomal topical delivery and skin deposition |
Three independent evidence streams converge in one ingredient platform.
21 · INNOVATION SUMMARY
A Complete Lipid Engineering Solution
| Platform element | Content |
|---|---|
| Functional Lipid | Batyl Alcohol |
| Biomimetic Barrier Matrix | Ceramide NP · Cholesterol · Stearic Acid |
| Nano Delivery Technology | PURISOME® Nanoliposomes |
NanoActive™ BatyCer™: Biomimetic Skin Barrier Lipid Platform — PuriPharm Co. Ltd.
22 · SCIENTIFIC REFERENCES
Peer-Reviewed Foundation
| 01 | [1] Bernal-Chávez SA, et al. Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators. Molecules. 2017;22(1):185. doi:10.3390/molecules22010185 |
| 02 | [2] Bektay HŞ, et al. The Design and Optimization of Ceramide NP-Loaded Liposomes to Restore the Skin Barrier. Pharmaceutics. 2023;15(12):2685. doi:10.3390/pharmaceutics15122685 |
FURTHER SUPPORTING LITERATURE
| 01 | — Stratum corneum lipid organization and lamellar phase behavior |
| 02 | — Ceramide / cholesterol / free fatty acid systems and accelerated barrier recovery |
| 03 | — Liposomal topical delivery and controlled skin deposition |
23 · CLOSING
NanoActive™ BatyCer™
An innovative cosmetic active platform combining biomimetic lipid science and nano delivery technology.
BIOMIMETIC SKIN BARRIER LIPID PLATFORM · PURIPHARM CO. LTD.