PuriActives® BioCalmin
Precision Molecular Soothing for Sensitive Skin & Scalp
PURIPHARM CO. LTD. — COSMETIC ACTIVE INGREDIENTS
PuriActives® BioCalmin
Precision Molecular Soothing for Sensitive Skin & Scalp
INCI: Hydroxyphenyl Propamidobenzoic AcidScientific name: Dihydroavenanthramide D (DHAvD), nature-inspired synthetic avenanthramide
Nature-Inspired Chemistry · Fast Comfort · Multi-Pathway Defense
THE CHALLENGE — SKIN BIOLOGY
When Skin Overreacts, Multiple Signals Converge
COMMON MANIFESTATIONS：Itching、Redness、Burning、Stinging、Tightness、Dryness、Irritation、Scalp discomfort
POTENTIAL TRIGGERS：SurfactantsEnvironmental stress、Dry skin、Shaving、Hair coloring、Bleaching、Exfoliating acid、Retinoids、Frequent cleansing、Compromised skin barrier
THE SIGNALING CASCADE — SCHEMATIC
External Stress
↓
Sensory Nerve Activation · Substance P
↓
Mast Cell Activation
↓
Histamine + Inflammatory Mediators
↓
Itch · Redness · Discomfort
One trigger can set off the full neurogenic irritation chain — effective soothing starts upstream.
THE MOLECULE
Nature-Inspired Precision Chemistry
Dihydroavenanthramide D (DHAvD) | MW ≈ 285.3 Da | logP ≈ 3.34
| Item | Information |
|---|---|
| INCI NAME | Hydroxyphenyl Propamidobenzoic Acid |
| SCIENTIFIC NAME | Dihydroavenanthramide D (DHAvD) |
| INGREDIENT FAMILY | Nature-inspired synthetic avenanthramide |
A synthetic analogue nature-inspired by oat avenanthramides — the phenolic anthranilic acid amides behind the protective chemistry of oats — engineered as a highly defined molecular active with consistent, reproducible performance.
Key actions
Anti-itchAnti-rednessAnti-histamine pathway
Product attributes
AntioxidantEffective at low concentrationsSkin & scalp soothing
Molecular properties per published pharmaceutical-formulation research on DHAvD. Highly defined molecular identity — not an oat extract. Activity at low concentrations, across both skin and scalp applications.
DESIGN LOGIC
From Oat Defense Chemistry to Targeted Cosmetic Soothing
Avenanthramides are anthranilic acid amides known for biological activities relevant to skin comfort. PuriActives® BioCalmin translates that biology into one defined, reproducible molecule.
Oat Avenanthramide Biology
↓
Structure–Activity Understanding
↓
Dihydroavenanthramide D
↓
Consistent Molecular Soothing Performance
MOLECULAR ADVANTAGES
Controlled molecular identityReproducible quality, batch after batchStrong activity at ppm-level concentrations
MULTIFUNCTIONAL ADVANTAGES
Multifunctional soothing profileAntioxidant capacityBroad formulation potential
Nature-Inspired. Molecularly Defined.The premium positioning — beyond “naturalness”: defined, reproducible, potent.
MECHANISM
One Molecule. Four Levels of Skin Comfort.
NET RESULT: Less Itch · Less Redness · Less Irritation · More Comfort
01 Substance P / Mast Cell Pathway
Helps inhibit Substance P-induced histamine release from mast cells.
02 Histamine-Related Itch & Redness
Helps reduce downstream itch and erythema responses in challenged skin.
03 Inflammatory Signaling
Published mechanistic research supports modulation of NF-κB-related inflammatory signaling.
04 Oxidative Stress
Strong radical-scavenging activity helps limit the oxidative amplification of irritation.
MECHANISM IN FOCUS
Interrupting the Substance P–Mast Cell–Histamine Axis
Sensory Nerve
↓
Substance P
↓
Mast Cell
↓
Histamine
↓
Itch · Redness
PuriActives® BioCalmin inhibits Substance P-induced histamine release.
Substance P released from sensory nerves stimulates mast cells and promotes histamine release, driving itching, redness and neurogenic skin discomfort. Published studies show that synthetic avenanthramides including Dihydroavenanthramide D inhibit Substance P-induced histamine release from mast cells; the original patent literature describes anthranilic acid amides for precisely this purpose.
Target the Signal Before It Becomes Visible Discomfort.
Evidence type: in vitro mast-cell assay; patent literature.
EVIDENCE — IN VITRO
Strong Activity at ppm-Level Concentrations
−81%histamine net release at 500 ppm DHAvD vs. stimulated control
Published in-vitro mast-cell results show progressive, dose-dependent suppression of histamine net release as DHAvD concentration rises from 0.5 to 500 ppm — potent activity well below typical use levels.
Histamine net release relative to Substance P-stimulated control (= 100%). Chart redrawn from published data.Source: Schmaus G, Herrmann M, Joppe H, Lange S, Koch O, Pillai R, Röding J. Dihydroavenanthramide D for Anti-irritant and Anti-itch. Cosmetics & Toiletries. 2007;122(11):55–66.
EVIDENCE — HUMAN IN VIVO
From Mast Cells to Human Skin
| HUMAN IN VIVO — HISTAMINE CHALLENGE | STUDY DESIGN |
|---|---|
| Method | Double-blind, placebo controlled |
| Challenge | Histamine challenge (skin-prick model) |
| Subjects | ≈ 10 subjects per study |
| Formulations | O/W emulsions with 500 ppm synthetic avenanthramides |
| Controls | Placebo & untreated controls |
| Assessment | Itch and redness scoring up to 180 minutes |
Itch Reduction
significantly lower vs placebo — p < 0.05
Redness Reduction
significantly lower vs placebo — p < 0.05
Schematic representation of the published outcome — synthetic avenanthramides including Dihydroavenanthramide D significantly reduced histamine-induced itch and redness versus placebo and untreated skin; bar heights are illustrative, not original quantitative values. Source: Schmaus G, et al. Cosmetics & Toiletries. 2007;122(11):55–66.
Visible Redness Down. Perceived Itch Down.
POTENCY
Powerful Soothing Does Not Require High Loading
500 ppm
= 0.05% active
The concentration that demonstrated meaningful anti-itch and anti-redness activity in the published human histamine-challenge model.
High biological potency
Meaningful activity at a low concentration.
Efficient formulation concept
Supports efficient formulation design.
Attractive in sophisticated sensitive-skin formulations
Suitable for advanced sensitive-skin products.
Compatible with multi-active cosmetic systems
Can be integrated into multi-active systems.
Published active concentration for Dihydroavenanthramide D (Schmaus G, et al. 2007). Final PuriActives® BioCalmin use level and assay: refer to the current PuriPharm TDS / SPEC.
EVIDENCE — ANTIOXIDANT
Soothing + Radical Defense
ABTS ANTIOXIDANT ASSAYIC50 = 26.54 μMIC50 = 7.57 μg/mL
Published ABTS data report radical-scavenging activity for DHAvD comparable with the reference antioxidants α-tocopherol and Trolox under the same assay conditions.
- Helps neutralize reactive radicals
- Helps reduce oxidative amplification of irritation
- Supports environmental-stress protection concepts
- Complements sensitive-skin and healthy-aging formulations
Calm Today. Defend Against Tomorrow’s Stress.
Source: Schmaus G, et al. Dihydroavenanthramide D for Anti-irritant and Anti-itch. Cosmetics & Toiletries. 2007;122(11):55–66.
MECHANISTIC CONTEXT
Beyond Histamine: Supporting Control of the Inflammatory Cascade
ROS / Cytokine Stress
↓
IκB degradation
↓
NF-κB Activation
↓
Inflammatory Mediator Expression
Published mechanistic studies on DHAvD demonstrate suppression of NF-κB-related signaling and downstream iNOS / NO responses in experimental biological models — a second, histamine-independent layer of the molecule’s soothing logic.
How to read this evidence: Supporting mechanistic evidence — not a direct clinical skin-efficacy claim. The experimental disease model in the source publication is not a product indication.
MECHANISTIC STUDY — NF-κB · iNOS · NOReference: Lv N, Song MY, Lee YR, et al. Biochem Biophys Res Commun. 2009;387(1):97–102.
MOLECULAR ROBUSTNESS
Stable Across a Remarkably Broad pH Window
Broad pH stability expands formulation possibilities.
pH 3 — pH 5 — pH 7 — pH 9 — pH 12
acidicalkaline
Published stability research evaluated DHAvD at pH 3 · 5 · 7 · 9 · 12 over 24 weeks and reported only slight degradation — even under very acidic and very alkaline conditions.
24 weeks of stability evaluation
WHERE BROAD pH STABILITY MATTERS
Facial skin careCleansing productsShaving products
MORE APPLICATIONS
Scalp productsHair coloring systemsBleaching-associated comfort concepts
Molecule-level stability data (published research; Schmaus G, et al. 2007). Final product pH range and handling: current PuriPharm TDS / SPEC.
FORMULATION SCIENCE
Unlocking Dermal Availability Through Smart Vehicle Design
Vehicle design determines how much DHAvD reaches viable skin.
EX VIVO HUMAN SKIN — FRANZ DIFFUSION
- 2–4× higher DHAvD release within 30 minutes with a 2% butylene glycol / pentylene glycol blend
- ≈ 2× penetration into viable skin layers within 30 minutes
- Sustained delivery advantage maintained over 300 minutes
41% vs 12% of the applied dose, optimized vs reference formulation.
Published formulation science using Dihydroavenanthramide D. Source: Heuschkel S, Wohlrab J, Schmaus G, Neubert RHH. Eur J Pharm Biopharm. 2008;70(1):239–247. doi:10.1016/j.ejpb.2008.04.005
SCALP CARE
Sensitive Scalp Is Sensitive Skin
WHAT SENSITIVE SCALP FEELS LIKE
Itching · Burning · Redness · Dryness · Tightness · Dandruff-associated discomfort · Irritation after coloration or bleaching
WHERE BIOCALMIN FITS
Scalp soothing tonicsSensitive-scalp shampoosAnti-dandruff shampoosScalp serums
MORE APPLICATIONS
Dry-scalp treatmentsHair-color aftercareBleaching / perming comfortDaily scalp care
Comfort Starts at the Scalp.
EVIDENCE — CLINICAL SCALP STUDY
Noticeable Scalp Comfort in 30 Minutes
−57%
scalp itch vs. placebo
after 30 minutes · single application · p < 0.05
| CLINICAL SCALP STUDY | Information |
|---|---|
| Participants | 18 volunteers with itchy scalp |
| Test formulation | 1% tested same-active formulation |
| Design | Single application, placebo controlled |
| Evaluation | 30-minute evaluation |
Relative scalp itch (placebo = 100%).
Source: Published same-active scalp clinical study; n = 18; 30-minute single-application evaluation. Chart redrawn in the PuriPharm visual system.
EVIDENCE — CLINICAL SCALP STUDY
Immediate Comfort. Sustained Performance.
CLINICAL SCALP STUDY — 5 DAYS−40% itching vs. baseline after five days−47% itching vs. placebo after five days
The same study reported a marked reduction in burning sensation.
−40% vs baseline
−47% vs placebo
From Fast Relief to Daily Scalp Comfort
18 volunteers with itchy scalp · once-daily use · 5-day treatment · placebo comparison · symptom scores for itching and burning. Published same-active scalp clinical study; charts redrawn from reported results.
SCALP CARE — COMBINATION CONCEPT
Go Beyond Flake Control
Anti-Dandruff Active + Dihydroavenanthramide D
↓
Flake Management + Itch Comfort
Published patent literature reports combinations of DHAvD with climbazole for itchy scalp and anti-dandruff applications. Human studies described in the patent showed improved itch reduction when the two actives were combined — the anti-dandruff active manages flakes while DHAvD addresses the itch signal.
0.05% DHAvD + 0.2% ClimbazoleSynergy index 0.77synergistically enhanced itch-relieving activity in the patent dataset
APPLICATIONS: Anti-dandruff shampoo · Anti-dandruff scalp serum · Scalp lotion · Itchy dry-scalp products
PATENT REFERENCES:WO2004047833A2 — Anthranilic acid amides and derivatives thereof as cosmetic and pharmaceutical agents (2004)WO2007062957A1 / EP1959915B1 / US8911795B2 — Anthranilic acid amide + anti-dandruff active combinations for itch relief (2007)
APPLICATIONS — SKIN CARE
High-Performance Soothing Across Skin-Care Categories
Add Comfort Without Compromising Performance.
SENSITIVE SKIN
Sensitive-skin serumSoothing essenceRedness-care creamDaily comfort moisturizerSensitive body lotion
HIGH-ACTIVITY SKIN CARE
Retinoid companion careAHA / BHA / PHA formulationsBrightening systemsPost-exfoliation careAdvanced anti-aging formulas
STRESS & RECOVERY
After-sunAfter-shavePost-cleansing comfortDry, itchy-feeling skin careMask formulationsEnvironmental-stress products
APPLICATIONS — HAIR & SCALP
A Dedicated Soothing Strategy for Modern Scalp Care
APPLICATION CONCEPTS
Sensitive scalp shampooScalp soothing tonicAnti-dandruff shampooAnti-dandruff serumDry scalp care
MORE FORMATS
Scalp essencePost-hair-color carePost-bleaching comfortRelaxing / straightening aftercareLeave-on scalp spray
CORE BENEFIT ARCHITECTURE
Anti-ItchAnti-RednessScalp ComfortAnti-Dandruff SupportPost-Chemical-Treatment Soothing
From sensitive-skin care to advanced scalp comfort — one molecule, two territories.
WHY PURIACTIVES® BIOCALMIN
Calm the Signal. Restore the Comfort.
PuriActives® BioCalmin — Hydroxyphenyl Propamidobenzoic Acid. A precision molecule for next-generation soothing formulations, from sensitive-skin care to advanced scalp comfort.
FAST
Rapidly helps relieve itch and discomfort.
TARGETED
Acts on the Substance P–mast cell–histamine pathway.
PROVEN
Supported by human, cellular and formulation research.
MULTIFUNCTIONAL
Soothing + redness care + antioxidant defense.
VERSATILE
Designed for advanced skin and scalp concepts.