Puri-Xyl THE 3D HYDRATION EXPERT
Signs of Imbalance
Environmental stress and aging disrupt the skin’s natural water balance, leading to:
- Visual Dryness:Flaking and dullness.
- Physical Discomfort:Tightness and roughness.
- Structural Weakness:Compromised barrier function.
The Goal: To restore equilibrium between water reserves and water loss.
Introducing Puri-Xyl
Natural Sugar Technology:
Puri-Xylis auniquecomplex of natural sugars derived fromWheat andCorn. It represents a green chemistry approach to skin hydration.
INCI Name: Xylitylglucoside,Anhydroxylitol, Xylitol
Key Attributes: Preservative-free,Allergen-free, Non-GMO.
Green Synthesis & Structure
TheHydraconcept: 3D Hydration
Mechanism 1: Dermal Reserves
Mechanism 2: Barrier Function
Ceramide Synthesis: A healthy barrier relies on the “mortar” holding cells together. Puri-Xylsignificantly stimulates the synthesis ofCeramides 1 & 2.
The Result: This creates an “Anti-Dehydration Shield,” physically preventing water from evaporating and protecting against external aggressors.
Mechanism 3: Water Circulation
Aquaporins (AQP3): Puri-Xylupregulates Aquaporin-3, the dedicated water channels in cell membranes. This ensures active transport of water and glycerol from the dermis to the epidermis.
Tight Junctions: By reinforcing tight junctions, Puri-Xylensures that water flow is controlled and distributed evenly throughout the epidermal layers, maximizing hydration efficacy.
Clinical Evaluation Protocol
Deep Hydration Kinetics
Anti-Dehydration Shield
Skin Restructuring
Smoothing & Normalization
Puri-Xyl doesn’t just hydrate; it restructures the skin surface by normalizing the desquamation process.
+25% Improvement in desquamation (less flaking).
+30% Improvement in skin micro-relief (smoother texture).
Visual Result: Skin looks plump, healthy, and radiant.
Safety & Tolerance
Technical Profile
Versatile Applications
Puri-Xyl PRODUCT DATA SHEET
PRODUCT DATA SHEET
Product Name: Puri-Xyl
Version: 2.0
Supplier: PuriPharm Co. Ltd.
1. PRODUCT OVERVIEW
Puri-Xyl is a moisturizing and restructuring complex derived from natural plant sugars. It is designed to harmonize the hydrous flow of the skin based on the “3D Hydration” concept, ensuring comprehensive hydration across all skin layers.
- INCI Name: Xylitylglucoside, Anhydroxylitol, Xylitol
- Product Category: Active Ingredient / Moisturizer
- Origin: Plant-derived (Wheat & Corn)
- Compliance: Preservative-free, Non-GMO, Allergen-free
2. KEY BENEFITS
Puri-Xyl optimizes the skin’s water flow, offering both immediate and long-term moisturizing benefits while reinforcing the skin barrier and improving surface texture.
- Hydration Reservoir: Significantly boosts dermal water reserves (Glycosaminoglycans/GAGs).
- Barrier Function: Stimulates ceramide synthesis to limit Trans-Epidermal Water Loss (TEWL).
- Water Circulation: Optimizes the expression of Aquaporins to facilitate epidermal water flow.
- Restructuring: Normalizes the desquamation process for smoother skin.
- Visual Improvement: Reduces flaking/dryness and smooths micro-relief.
3. COMPOSITION
4. MECHANISM OF ACTION
Puri-Xyl acts on three levels of the skin:
1.Dermis (Reserves): Significantly increases the synthesis of Glycosaminoglycans (GAGs).
- Chondroitin Sulfate: +183%
- Hyaluronic Acid: +20% (Epidermis), +55% (Dermis)
2.Epidermis (Flow): Stimulates the expression ofAquaporin-3 (AQP3)to facilitate water and glycerol transport between cells; strengthens Tight Junctions.
3.Stratum Corneum (Barrier): Promotes the synthesis of Ceramides 1 and 2, reinforcing the intercellular lipid cement to create an “Anti-Dehydration Shield.”
5. EFFICACY DATA
In-Vivo Study: 25 volunteers with dry skin applied a lotion containing 3% Puri-Xyl twice daily for 30 days.
●Anti-Dehydration Shield: After 30 days, Trans-Epidermal Water Loss (TEWL) was significantly reduced by-13%.
●Hydration Kinetics:
○24 Hours:Immediate barrier reinforcement observed.
○8 Days:Visible improvement in hydration.
○30 Days:Maximum hydration effect achieved.
●Skin Restructuring:
○Desquamation Improvement:+25%(Reduced flaking)
○Skin Micro-relief:+30%(Smoother texture)
6. PHYSICAL PROPERTIES
- Appearance: Liquid
- Color: Colorless to pale yellow
- Odor: Characteristic, faint
- Solubility: Soluble in water, alcohol, and glycols
- Shelf Life:24 months
7. FORMULATION GUIDELINES
- Recommended Dosage:1.5% – 5.0% (Clinically tested at 3%)
- Incorporation: Can be added at any stage of the formulation process (aqueous phase or end).
- pH Stability:Stable over a wide pH range (pH 3.0 – 10.0).
- Thermal Stability:Excellent; can withstand heating up to 80°C.
- Compatibility: No known incompatibilities; compatible with high electrolyte concentrations.
8. SAFETY & TOXICOLOGY
- Skin Tolerance:Excellent (48-hour Patch Test).
- Ocular Tolerance:Good (HET-CAM Test).
- Sensitization: Non-sensitizing.
- Mutagenicity: Non-mutagenic (Ames Test).
9. APPLICATIONS
Suitable for various cosmetic formulations:
- Face Care: Daily moisturizers, anti-aging serums, night creams.
- Body Care: Body lotions, hand creams, shower gels (reduces surfactant irritation).
- Hair Care:Scalp hydration treatments, shampoos, conditioners.
- Specific Care: Products for dry/sensitive skin, after-sun care.
Disclaimer: The information contained in this data sheet is based on our current knowledge. It is the user’s responsibility to verify the suitability of the product for their specific application.
NanoActive r-RETINOATE PRODUCT DATA SHEET
PRODUCT DATA SHEET
Product Name: NanoActive r-RETINOATE
Manufacturer: PuriPharm Co., Ltd.
Awards: 2019 Ringier Technology Innovation Award (Personal Care)
1. Product Overview
NanoActive r-RETINOATEis a next-generation, high-performance Vitamin A derivative engineered to overcome the traditional limitations of retinoid application in cosmetic science. Utilizing a proprietary 20–30 nm nano-encapsulation delivery system, this bioactive ingredient combines exceptional anti-aging efficacy with unprecedented stability and skin tolerability.
Formed by esterifying the hydroxyl group of retinol with retinoic acid, Retinyl Retinoate retains the bioactivity of both precursor molecules. It delivers up to 8x the activity of standard retinol while eliminating the characteristic irritation and photosensitivity. Crucially, its distinctive blue-light absorption profile and high photostability make it a breakthrough retinoid that is completely safe and effective for daytime application.
2. Chemical Description & Composition
- INCI Name: Retinyl Retinoate, Ascorbic Acid (Vitamin C), Phospholipids, Caprylic/Capric Triglyceride, Glycerin, Water
- Product Type: Nano-encapsulated Bioactive System
- Active Concentration: Available in 1.0% or 5.0% Retinyl Retinoate specifications
3. Physical & Chemical Properties
- Appearance: Yellow-orange viscous liquid
- Odor: Characteristic
- pH Value: 5.0 – 8.0
- Solubility: Amphiphilic (compatible with both water and oil phases)
- Photostability: Excellent (not light-sensitive; suitable for day-care formulations)
4. Platform Technology & Delivery System
PuriPharm’s advanced nano-delivery platform transforms how retinoids interact with the skin structure:
- Targeted Follicular Absorption: The 20–30 nm particle size allows the nanocarriers to accumulate efficiently within the hair follicle pathway. This creates a deep-skin “follicular reservoir” where actives can be retained rather than merely remaining on the skin’s surface.
- Sustained Release Kinetics: Once deposited in the appendages, the nano-emulsion structure facilitates a controlled, slow-release mechanism that extends the activity window for more than 10 days, ensuring long-lasting efficacy without overwhelming the skin barrier.
- Unique Occlusion Effect: Nano-sized lipid carriers create a highly uniform, tight surface film, increasing residence time and local deposition of the active compound.
5. Mechanism of Action: The One-Step Advantage
Traditional retinol formulations require a slow, three-step metabolic conversion (Retinyl Esters → Retinol → Retinal → Retinoic Acid) to become biologically active.
NanoActive r-RETINOATE features a direct “One-Step Conversion.”As a direct precursor, it is highly efficient and minimizes intermediate degradation.
Biocompatibility & Cytotoxicity:
In vitro data demonstrates that Retinyl Retinoate possesses significantly lower cytotoxicity compared to standard retinol. The IC50 of retinol is 25 μM, whereas the IC50 of NanoActive r-RETINOATE is 40 μM (an approximately 60% improvement in cellular tolerability), showcasing its ability to provide intense rejuvenation without the peeling, erythema, and barrier compromise associated with traditional Vitamin A.
6. Proven Cosmetic Benefits & Efficacy Data
A. Profound Anti-Aging & UV Repair (12-Week Clinical Study)
A controlled clinical trial comparing 0.06% Retinyl Retinoate (Group A) against 0.075% Retinol (Group B) applied twice daily demonstrated superior anti-aging performance:
- Elasticity Improvement: 90.9% of Group A subjects reported noticeable periocular elasticity improvement (vs. 81.8% in Group B).
- Photodamage Reversal: Group A exhibited an 8.61% measurable improvement in photodamage repair (vs. 7.43% in Group B).
- Longevity of Efficacy: NanoActive r-RETINOATE showed a significantly weaker “diminishing marginal effect,” meaning anti-wrinkle benefits continued to compound and remain highly visible even over long-term (1 year+) usage.
B. Hyaluronic Acid (HA) Expression
In vivotesting on epidermal and dermal tissues (HABP staining) confirms that NanoActive r-RETINOATE significantly upregulates endogenous mucopolysaccharide (hyaluronic acid) synthesis, heavily outperforming both standard retinol and retinoic acid.
C. Multi-Pathway Skin Enhancement
- Structural Integrity: Inhibits UV-induced Matrix Metalloproteinases (MMP) activity, reducing the breakdown of endogenous proteins, protecting elastic fibers, and promoting collagen synthesis.
- Tone & Clarity: Works synergistically with its Vitamin C component to inhibit tyrosinase, accelerate melanin metabolism, and reduce visible redness.
- Texture & Blemishes: Promotes healthy keratinocyte activity, increases epidermal thickness, and functions via multiple mechanisms to clear blemishes and accelerate the repair of acne marks.
7. Formulation Guidance
NanoActive r-RETINOATE is engineered for formulation elegance and versatility:
- Recommended Use Level: 1.0% – 5.0%
- Optimum pH Range: 3.0 – 6.5
- Processing: Simple to formulate. Add to the system at the final stage of manufacturing (post-emulsification, during the cooling phase) to protect the nanostructure.
- Compatibility: Highly compatible with a wide range of cosmetic matrices. Works exceptionally well in synergy with additional Hyaluronic Acid, Vitamin C, and biocomposite polysaccharides (e.g., hydrolyzed myrtle) for accelerated wrinkle-reduction claims.
8. Recommended Applications
- Daytime Anti-Aging Care: Day creams, lotions, and serums targeting fine lines, leveraging its unique photostability.
- Intensive Photodamage Repair: Post-sun recovery formulations and deep wrinkle repair treatments.
- Advanced Brightening: Radiance serums addressing hyperpigmentation and uneven skin tone (pairs perfectly with brightening regimens).
- Acne & Barrier Repair: Clarifying formulations aimed at treating blemishes, repairing acne marks, and thickening the epidermal layer.
Disclaimer: This document is provided for informational and technical support purposes only, based on PuriPharm Co., Ltd. research and development data. Formulators are responsible for conducting full stability, compatibility, and safety evaluations of their finished cosmetic products. PuriPharm Co., Ltd. makes no warranties regarding the specific outcomes of end-user formulations.
NanoActive r-RETINOATE
NanoActive r-RETINOATE
8× retinol activity
Photostable • Non-irritating
A next-generation vitamin A derivative
Company Overview
PuriPharm Biopharmaceutical Technology Co., Ltd.
Delivering Beauty • Creating Value
Focused on the research and development of bioactives.
- Specialized in the development of bioactive materials and functional ingredient systems.
- Combines scientific delivery technology with application-oriented product design.
- Dedicated to high-performance ingredients for beauty and personal care.
Nano Delivery Technology
- One of the most widely studied and applied new formulation technologies.
- Applicable across pharmaceuticals, foods, cosmetics and other fields.
- Nano-bioactives are new products developed using nanodelivery systems.
- Improves solubility, stability, irritation profile and odor while offering unique biological effects.
Fourth-Generation (4G) Cosmetic Ingredients
- Clearly defined ingredients and content
- Clearly defined targets
- Clear mechanism of action
- Formulations designed to preserve bioactivity
- Good solubility
- Stable and non-discoloring
- Easy to absorb
A perfect combination of traditional medicine, modern biotechnology and nanotechnology.
Unique Occlusion Effect
Follicular Targeted Absorption
- Nanocarriers accumulate efficiently around the hair follicle pathway.
- This supports targeted delivery into deep skin appendages where actives can be retained and released.
Key takeaway：Hair follicles provide an efficient access route for targeted nano-delivery.
Smaller Particles Penetrate Deeper
and in Greater Amounts
- Reduced particle size increases penetration depth in skin.
- Smaller particles also increase the delivered amount of active ingredient.
The smaller the carrier, the deeper the penetration and the higher the delivery amount.
Follicular Reservoir Enables Slow Release for
More Than 10 Days
- Hair follicles act as a storage reservoir for the active ingredient.
- The active can be released gradually for more than 10 days after deposition.
- This supports long-lasting efficacy with sustained local availability.
Long-lasting delivery：Slow release extends the activity window after follicular deposition.
Vitamin A：
A core scientific foundation for the product story
Functions of Vitamin A in the Human Body
- Supports vision and visual signaling.
- Contributes to growth, reproduction and immune support.
- Involved in antioxidant defense, cell differentiation and gene transcription.
Vitamin A and Nobel Prizes
Vitamin A Is the Gold Standard in Anti-Aging Skincare
Common Vitamin A Actives Used in Skincare
Conversion to Retinoic Acid in Vivo
Why It Won the Award
2019 Ringier Technology Innovation Award
- Vitamin A derivative suitable for daytime use
- Safe and low irritation
- Nano-encapsulation protects the active ingredient
- A breakthrough and a new technical approach for retinoid raw materials
A distinctive retinoid concept that balances efficacy, stability and tolerability.
Unique Absorption Spectrum
- Distinctive absorption profile
- Efficient blue-light absorption
- Good photostability
Product Introduction
- Retinyl retinoate is obtained by esterifying the hydroxyl group of retinol with retinoic acid, while avoiding the application limits of retinol and retinoic acid in cosmetics.
- NanoActive r-RETINOATE has an encapsulated particle size of 20–30 nm. This nanoemulsion size keeps the active stably suspended in the nanocarrier, enhances skin penetration and helps control the release rate.
Particle size：20–30 nm nano-encapsulation；
Delivery effect：Stable suspension, enhanced penetration and controlled release
Product Introduction
Skincare Benefits of Retinyl Retinoate
Efficacy Summary
Product Description
Formulation Guide
Suitable Products
Anti-aging products：
Maintains collagen in the dermis and helps prevent excessive collagen degradation.
When combined with hyaluronic acid and biocomposite polysaccharides (hydrolyzed myrtle), improvement in fine lines can be observed within one week.
Brightening products：
Works synergistically with vitamin C to inhibit tyrosinase, promote metabolism and accelerate fading of melanin.
The source deck notes that pairing with vitamin C is also effective for acne-prone skin.
Suitable Products
Sunscreen products：
Inhibits the UV-induced increase of MMP activity and helps protect elastic fibers and dermal collagen.
Improves wrinkles and fine lines caused by UV exposure.
Repair products：
Promotes endogenous hyaluronic acid synthesis and reduces skin TEWL.
Promotes keratinocyte activity and increases epidermal thickness, making the epidermis stronger.
NanoActive MN PRODUCT DATA SHEET
Manufacturer: PuriPharm Co. Ltd.
1. Product Overview
NanoActive MN is an advanced, high-performance bioactive ingredient engineered specifically for premium skin and hair care formulations. Utilizing state-of-the-art nano-delivery technology, NanoActive MN features a specialized lipophilic tail that drastically improves skin penetration while minimizing the irritation and sensitization traditionally associated with unmodified nicotinic acid.
Once delivered into the skin, it undergoes targeted conversion into Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme that orchestrates cellular energy metabolism, DNA repair, and lipid synthesis, fundamentally reversing the age-related decline of skin and hair follicle vitality.
2. INCI & Chemical Information
- INCI Name: Myristyl Nicotinate
- Product Type: Nano-encapsulated Bioactive Agent
3. Technology Highlights
PuriPharm Co. Ltd. leverages proprietary core technologies to ensure maximum efficacy:
- Nano Delivery System: Advanced nanotechnology ensures optimized bioavailability and targeted, deep-layer delivery of the active compound.
- Enhanced Penetration: The lipophilic modification facilitates superior transepidermal transportation.
- Targeted Action: Precisely targets local skin cells and hair follicles where esterase activity initiates the conversion process.
- Improved Stability: Formulated to protect the active core, ensuring long-term shelf-life and robust compatibility within complex cosmetic matrices.
4. Mechanism of Action: The NAD+ Pathway
NAD+ levels natively decline by up to 50% by middle age, leading to compromised cellular repair and energy metabolism.
NanoActive MN effectively addresses this:
- Enzymatic Cleavage: Upon penetration, native skin esterases selectively cleave the lipophilic tail of NanoActive MN.
- Conversion: The molecule is efficiently converted into the active coenzyme NAD+ via cellular synthetic pathways.
- Cellular Optimization: The synthesized NAD+ directly fuels mitochondrial energy generation, upregulates barrier lipid synthesis, and supports genomic (DNA) repair, combating oxidative stress and cellular senescence.
5. Proven Cosmetic Benefits & Efficacy Data
NanoActive MN has demonstrated remarkable results across comprehensive clinical andin vitroevaluations:
A. Profound Skin Barrier Repair
- Visual & Structural Improvement: Clinical studies demonstrate a 250% improvement in barrier function on facial skin and an 11% improvement on the forearm volar surface (at 5% use level).
- Epidermal Fortification: Induces a highly significant 70% increase in epidermal thickness (compared to a 13% increase in the control group).
- Tight Junction Enhancement: Upregulates ZO-1 protein expression (3.38-fold relative expression at 0.04 mg/mL), physically reinforcing the skin barrier.
B. Anti-Aging & Cellular Renewal
- Accelerated Renewal: Safely accelerates skin cell renewal by reducing Dansyl turnover time and increasing Minimal Erythema Dose (MED) without inducing photosensitivity.
- Antioxidant Capacity: Exhibits excellent DPPH radical scavenging ability (6.10% maximum clearance at 0.3125%).
C. Hair Follicle Vitality & Anti-Hair Loss
- Scalp Energy: Converts to NAD+ within the scalp, enhancing cellular ATP, stimulating follicle cell renewal, and actively neutralizing oxidative stress.
- Clinical Hair Improvement: Well-designed clinical trials confirm significant improvements in hair abundance, density, hair shaft thickness, and overall hair quality with zero reported adverse effects.
D. Synergistic Efficacy with Retinoids
- Retinol Companion: When formulated alongside retinoic acid or its derivatives, NanoActive MN acts as a potent buffer—significantly reducing retinoid-induced irritation and Transepidermal Water Loss (TEWL) while amplifying overall anti-aging efficacy.
6. Formulation Guidance & Compatibility
NanoActive MN is designed for seamless integration into modern cosmetic chemistry.
- Suggested Use Level: 0.2% – 5.0%
- Suitable Formulations: O/W and W/O Emulsion systems, Creams, Lotions, Serums, Essential Oils, Massage Oils, and Cleansing products.
- Ingredient Compatibility: Exhibits excellent compatibility with a wide array of cosmetic raw materials including UV filters, emollients, humectants, natural oils, potent antioxidants, emulsifiers, thickeners, and retinoids. Minimal degradation is observed even in complex formulation matrices.
7. Recommended Applications
- Advanced Facial Care: Anti-aging creams, barrier-repair lotions, and high-potency cellular regeneration serums.
- Eye Care: Non-irritating eye creams and serums targeting fine lines and delicate skin reinforcement.
- Hair & Scalp Care: Anti-hair loss treatments, scalp energizing tonics, and hair density serums.
- Color Cosmetics: Functional lipsticks, lip glosses, eyeliners, and mascaras requiring bioactive support.
8. Storage, Stability, and Handling
- Long-Term Stability: Demonstrates exceptional stability; viable for 24 months at room temperature in various formulations. Withstands accelerated stability testing (3 months at 40°C).
- Storage Conditions: Store in a cool, dry environment between 4°C and 25°C. Protect from direct sunlight and moisture. Keep the original container tightly sealed when not in use.
Disclaimer:The information contained in this document is provided in good faith and is based on our current laboratory data and technical knowledge. It is intended for informational purposes only. Formulators are responsible for ensuring the stability, safety, and legal compliance of their final consumer products. PuriPharm Co. Ltd. makes no warranties, expressed or implied, regarding the use of this product.
NanoActive MN Advanced Bioactive Ingredient for Skin and Hair Care
Product Overview
INCI Name
The INCI name is MyristylNicotinate, which is the standardized name in the cosmetic industry.
Product Type
It is an advanced bioactive ingredient specifically designed for skin and hair care products.
Key Feature
It can convert to NAD + in skin cells, improving penetration and reducing irritation compared to regular nicotinic acid.
Features & Applications
Applications
Mechanism of Action
The NAD + pathways and conversion process ofNanoActiveMN
NAD+ Pathways
NAD+ Importance
NAD + is essential for energy generation in mitochondria, lipid synthesis, DNA damage repair, and maintaining mitochondrial function and telomere length.
NAD+ Synthesis Pathways
There are three main pathways: the de novo pathway starting from tryptophan, the Preiss – Handler pathway using nicotinic acid, and the salvage pathway recycling NAD + metabolites.
NAD+ and Skin Health
NAD + is critical for cellular repair, energy metabolism, and combating age – related decline in skin. Its levels decrease by 50% by middle age.
NanoActiveMN Conversion
Efficacy Data
Barrier Repair：
Efficacy data on skin barrier repair
Anti – aging & Antioxidant
1. DPPH Radical Scavenging
The maximum clearance is 6.10% at a concentration of 0.3125%, showing its antioxidant ability.
2. ZO – 1 Protein Expression
At 0.04 mg/mL concentration, there is a 3.38 – fold relative expression of ZO – 1 protein.
3. Synergistic Effects with Retinoic Acid
It reduces irritation, enhances efficacy, and reduces water loss when used with retinoic acid.
Hair Loss Prevention
1. Clinical Study Design
A well – designed study was conducted to evaluate the efficacy ofNanoActiveMN on hair loss prevention.
2. Study Results
There was a significant improvement in hair abundance, density, quality, and thickness, with no adverse effects reported.
3. Mechanism of Action
It converts to NAD + in the scalp, enhancing cellular energy, improving barrier function, stimulating hair follicle cell renewal, and reducing oxidative stress.
Company Introduction
PuriPharmCo. Ltd.
1. Company Background
Specialized in bioactive ingredients, founded by industry experts and has global partnerships with research institutions.
2. Quality & Manufacturing
Strict quality control standards, state – of – the – art manufacturing facilities, and sustainable practices are in place.
3. R&D Capabilities
An expert technical team with PhD – level scientists and advanced laboratory facilities for cosmetic ingredient development.
Core Technologies
Nano Delivery：Advanced nanotechnology for enhanced bioavailability and targeted delivery of active ingredients.
Targeted Action：Allows for targeted action of ingredients at specific skin or hair sites.
Enhanced Penetration：Improves the penetration of ingredients into the skin for better efficacy.
Improved Stability： Ensures the stability of formulations during storage and use.
Formulation Stability
Stability information under different conditions
1. 24 – months Stability at Room Temperature
NanoActiveMN shows good stability in various formulations at room temperature for 24 months.
2. 3 – months Stability at 40℃
It has 3 – months stability at 40℃ in accelerated testing.
3. Minimal Degradation in Complex Formulations
There is minimal degradation in complex cosmetic matrices, ensuring long – term effectiveness.
Storage & Compatibility
Storage Conditions：
Store at 4 – 25℃ in a dry environment, protect from light, and keep the container tightly sealed.
Tested Formulations
It has been tested with various ingredients such as UV filters, emollients, humectants, natural oils, etc.
Ingredient Compatibility
Compatible with a wide range of cosmetic ingredients, including retinoids, antioxidants, emulsifiers, and thickeners.
NanoActive SA Nano-scale Formulations of Health Ingredients
Skincare Benefits and Market Applications of Salicylic Acid (I)
- Exfoliates the skin, improves firmness, helps restore youthful elasticity, lightens pigmentation, reduces fine lines, and improves photoaging caused by sun exposure.
- Mechanism: Salicylic acid causes corneocyte membranes to suddenly lose negative charge, weakening cohesion and promoting desquamation.
- Representative product: SK-II crystal resurfacing cream.
- By adding 1.5% salicylic acid to the original Pitera formula and likening its pore- and keratin-refining effect to peeling a shelled egg, the product sparked strong market enthusiasm.
Skincare Benefits and Market Applications of Salicylic Acid (II)
Clears acne, tightens pores, removes blackheads from pores, and provides antibacterial benefits to address oily skin concerns.
Mechanism: Because salicylic acid is lipophilic, it can merge with lipids and penetrate the stratum corneum and deep into pores, helping dissolve aged keratin buildup and improve pore blockage.
Representative product: Vichy oil-control purifying astringent toner.
An ideal conditioning product for problem skin. It further cleanses and repairs the skin, makes pores appear tighter, evens skin tone, and visibly improves shine and blackheads.
Skincare Benefits and Market Applications of Salicylic Acid
The two skincare functions above—exfoliation and oily-skin care—are exactly what the Chinese market needs.
- Most Chinese consumers have combination skin and face issues such as shine, enlarged pores, and acne.
- The air environment in China still needs improvement. Air pollution can cause thickening of the stratum corneum, dull-looking skin, and the accumulation of bacteria in the horny layer.
The market needs products containing salicylic acid.
Issues with Conventional Salicylic Acid
When pure salicylic acid is used in cosmetics, the following difficulties arise:
- It can be irritating and may cause erythema, itching, stinging, or allergic reactions.
- It has poor solubility. Salicylic acid is only slightly soluble in water, which limits formulation applications.
- Its activity depends on pH. In a low-pH environment, maintaining the free-acid form is important for efficacy.
Solution
In view of the issues above, PuriPharm Co. Ltd. developed NanoActive SA to ensure that salicylic acid can perform its skincare functions more effectively in cosmetics.
NanoActive SA delivers salicylic acid benefits more effectively while reducing irritation and related concerns.
Product Features
Salicylic acid remains in the free-acid form within the nano-carrier, effectively overcoming pH dependence.
Significantly reduces irritation and other adverse reactions associated with salicylic acid.
Completely water-soluble and can also be formulated in oil.
Clear, transparent, convenient, and easy to use.
Unique nanobiological effects such as follicular targeting and a follicular reservoir.
Product Characterization
Laser Particle Size Distribution
Electron Micrograph
NanoActive SA: Evaluation in Oily Skin Care
96% of users were satisfied with products containing NanoActive SA
Comprehensive improvement in oily skin
- Tightened pores
- Reduced sebum secretion
- Fewer comedones
NanoActive SA: Significant Efficacy in Acne Treatment
NanoActive SA: Applications
Enhances skin absorption. When salicylic acid is used with other skincare ingredients, it can improve the skin’s uptake of active ingredients.
Clears pore blockage. This mild acid helps break down blackheads and whiteheads by shedding the outermost layer of dead skin.
Exfoliates and cleanses. Salicylic acid is a keratolytic agent and also provides antibacterial benefits.
Removes dead skin cells and helps prevent acne caused when they mix with dirt and sebum.
Helps resist dryness. Salicylic acid softens keratin and helps defend against dry skin.
NanoActive SA: Use Guidelines
Add during the low-temperature stage.
Recommended dosage: 1–5%.
Avoid ferrous/ferric and other divalent or trivalent metal ions in the formulation system.
NanoActive SA
1. PRODUCT OVERVIEW
NanoActive SA is an innovative, high-performance delivery system of Salicylic Acid designed specifically for advanced personal care and dermatological formulations. While Salicylic Acid (BHA) is renowned for its exceptional comedolytic and keratolytic properties, its application is often restricted by poor water solubility, crystallization risks, and potential skin irritation at efficacious doses.
PuriPharm utilizes state-of-the-art liposomal nano-encapsulation technology to entrap Salicylic Acid within a biomimetic phospholipid and triglyceride matrix. This proprietary delivery system not only renders the active ingredient highly dispersible in aqueous environments but also ensures a sustained-release profile. The result is a profoundly stabilized, highly bioavailable active that maximizes targeted efficacy while virtually eliminating the stinging and erythema traditionally associated with chemical exfoliants.
2. INCI / CHEMICAL DESCRIPTION
The following composition reflects the typical concentration ranges formulated to ensure optimal encapsulation and stability.
3. KEY FEATURES & ADVANTAGES
- Superior Water Dispersibility: Seamlessly incorporates into clear aqueous systems, toners, and gels without the need for high concentrations of harsh solvents (e.g., alcohol or excessive glycols).
- Biomimetic Lipid Matrix: Utilizing phospholipids and natural triglycerides, the carrier system exhibits excellent skin affinity, actively replenishing the stratum corneum while delivering the BHA.
- Controlled & Sustained Release: Modulates the delivery rate of Salicylic Acid, significantly mitigating acute epidermal shock and reducing potential erythema or stinging.
- Crystallization Prevention: The nano-matrix physically prevents Salicylic Acid molecules from aggregating and precipitating over time, ensuring long-term shelf stability of the finished cosmetic product.
4. MECHANISM & TECHNOLOGY HIGHLIGHTS
Targeted Follicular Delivery via Nano-vesicles: NanoActive SA functions by enclosing the lipophilic Salicylic Acid core within a phospholipid-based outer shell. When applied to the skin, these sub-micron liposomal carriers exhibit a high affinity for the lipid-rich environment of the pilosebaceous unit. Upon penetrating the pore, the matrix undergoes a gradual degradation process triggered by the skin’s natural physiological environment, releasing the active payload continuously over several hours. This approach ensures maximum keratolytic action exactly where acnegenesis occurs.
5. PHYSICAL & CHEMICAL PROPERTIES
Safety & Purity Specifications:
- Heavy Metals: Pb < 10 mg/kg | As < 2 mg/kg | Hg < 1 mg/kg | Cd < 5 mg/kg
- Microbiology: Total Aerobic Count < 100 CFU/g | Yeast & Mold < 10 CFU/g
- Diethylene Glycol: < 1000 mg/kg
6. SOLUBILITY & COMPATIBILITY
- Solubility: Readily dispersible in water, glycols, and standard aqueous media.
- Compatibility: Highly compatible with a wide range of cosmetic excipients, including non-ionic and anionic surfactants, and standard thickeners. Avoid combining with strong alkaline agents that may disrupt the phospholipid encapsulation matrix.
7. PRODUCT BENEFITS & COSMETIC FUNCTIONS
- Intensive Anti-Acne: Reduces sebum secretion, unplugs impacted pores, and inhibits Cutibacterium acnes proliferation.
- Gentle Exfoliation: Promotes the shedding of dead keratinocytes, resulting in a smoother, more radiant complexion.
- Pore Minimizing: Clears cellular debris from pores, visibly reducing their appearance.
- Scalp Care (Anti-Dandruff): Effective in removing scalp buildup and regulating scalp hyperkeratosis without stripping hair shafts.
8. RECOMMENDED APPLICATIONS
- Facial Skincare: Anti-acne serums, clarifying toners, exfoliating lotions, spot treatments, and deep-cleansing masks.
- Cleansers: Foaming gel cleansers and purifying washes.
- Hair & Scalp Care: Anti-dandruff shampoos and scalp purifying serums.
9. SUGGESTED USE LEVEL & REGULATORY STATUS
- Suggested Use Level: 0.1% – 20.0%(Applicable for both leave-on and rinse-off formulations).(Note: A 20% addition of NanoActive SA delivers 2.0% of pure Salicylic Acid).
- Regulatory Restriction: Due to the presence of Salicylic Acid, this product is not to be used in products intended for children under 3 years of age, with the exception of shampoos.
10. FORMULATION GUIDANCE
- Processing Phase: It is highly recommended to add NanoActive SA during the final cooling phase of the manufacturing process, ideally at temperatures below 45°C (113°F), to preserve the integrity of the liposomal structure.
- pH Range: Maintain the final formulation pH between 3.5 and 6.0for optimal efficacy and stability.
- Agitation: Stir gently but thoroughly. Avoid extreme high-shear homogenization post-addition.
11. STORAGE AND HANDLING
- Storage Conditions: Store in tightly closed original containers in a cool, well-ventilated, and dry place. Optimal storage temperature is between 15°C and 25°C.
- Light & Temperature: Protect from direct sunlight, prolonged heat exposure, and freezing.
- Handling: Handle in accordance with good industrial hygiene and safety practices. Refer to the Material Safety Data Sheet (MSDS) for detailed safety instructions.
12. SHELF LIFE
24 months from the date of manufacture when stored properly in unopened original packaging under recommended conditions.
13. PACKAGING INFORMATION
Standard pack sizes available:
- 1 kg / 5 kg plastic fluorinated jugs
- 25 kg tightly sealed HDPE drums(Customized packaging available upon request).
CONTACT INFORMATION
PuriPharm Co. Ltd.
Building 6, No. 1366 Hongfeng Road,
Huzhou, Zhejiang, China
Tel:+86-572-2745768 Email:service@puripharm.com
DISCLAIMER:
The information provided in this Product Data Sheet is based on our current knowledge and represents typical characteristics. It is offered in good faith but without warranty. It is the responsibility of the formulator and the user to ensure that the final cosmetic product is safe, stable, and complies with all applicable local regulations and patent laws. PuriPharm Co. Ltd. reserves the right to modify product specifications without prior notice.
The Paradigm Shift in Advanced Skincare: From Bioactive Ingredients to Bio-mimetic Delivery Systems
Strategic Analysis of Nano-Encapsulated Retinaldehyde (NanoActive®RAL) as a High-Performance Alternative to Energy-Based Devices
1. The Evolution of Efficacy: Transitioning to “Clinical-Grade” Topical Solutions
The global skincare market is undergoing a fundamental shift from “Ingredient-Focused” (focusing on raw percentages) to “Science-Driven” (focusing on targeted delivery and bioavailability). A significant catalyst for this shift, particularly in the Asian and European markets, has been the 2024 regulatory tightening of home-use radiofrequency (RF) devices.As these devices are reclassified as medical instruments, a massive market gap has emerged for “RF-like” topical solutions capable of delivering measurable collagen-stimulating and skin-tightening results.
In this landscape,PuriPharm’s NanoActive® Retinal (RAL)delivery system has emerged as a premier commercial entry point. By leveraging pharmaceutical-grade nano-liposomes, PuriPharm addresses the historical “Triple Challenge” of Retinaldehyde: extreme instability, poor penetration, and high irritation potential.
2. Biochemical Logic: Why Retinaldehyde Outperforms Retinol
Vitamin A derivatives (retinoids) remain the gold standard in dermatology for stimulating the extracellular matrix (ECM). Their efficacy is determined by their proximity to Retinoic Acid in the metabolic pathway .
The “11x Efficiency” Factor
Traditional Retinol requires a two-step enzymatic oxidation to become active. In contrast, Retinaldehyde (RAL) is only one step away from Retinoic Acid. Scientific studies indicate that Retinaldehyde is approximately 11 times more efficientin bio-conversion than Retinol . This allows for significantly faster results in collagen synthesis, texture refinement, and wrinkle reduction even at lower concentrations .
3. NanoActive® Delivery System: Pharmaceutical-Grade Innovation
PuriPharm utilizes its proprietary Nano-Delivery System (NDS) to stabilize the “wild” nature of Retinaldehyde.
Ultra-Small Liposomal Architecture (<30nm)
NanoActive® RAL features a particle size precisely engineered to beunder 30nm (typically 20-30nm).This ultra-small scale, combined with a biomimetic phospholipid bilayer, provides two critical advantages:
1.Deep Dermal Penetration: The liposomal structure mimics skin cell membranes, allowing the active to bypass the stratum corneum and reach the deeper dermis more effectively than traditional emulsions.
2.“De-noising” Sustained Release: By encapsulating the RAL, the system provides a controlled release of the active. This “de-noising” process ensures a steady supply of energy to the skin while minimizing the common “Retinoid reaction” (redness, peeling, and stinging), making it suitable for sensitive skin types .
4. Clinical Evidence: Quantifiable Collagen Remodeling
The efficacy of PuriPharm’s NanoActive® RAL is substantiated by rigorous clinical testing. A 4-week independent human efficacy study conducted byIntertek (30 subjects, age 35-55) demonstrated the following results:
Instrument-Based Results (PRIMOS Analysis)
●Forehead Wrinkles: Count reduced by27.67%, total area reduced by11.98%.
●Crow’s Feet: Count reduced by31.05%, total area reduced by12.45%.
●Brightening (L Value)*: Significant increase in skin luminosity and ITA value, confirming a secondary whitening effect.
Subjective Satisfaction
●96.7% overall product satisfaction.
●93.3% of subjects reported visible improvements in skin firmness and elasticity.
●90.0% satisfaction regarding the reduction of fine lines under the eyes.
5. Innovation Highlight: NanoActive RETINAMIDE
For brands seeking “Day-to-Night” anti-aging solutions, PuriPharm has developed NanoActive RETINAMIDE, a stable amide derivative of retinoic acid conjugated with Polyethylene Glycol (PEG).
●Amide Bond Stability: Unlike HPR (Hydroxypinacolone Retinoate), RETINAMIDE is highly stable and does not hydrolyze into prohibited retinoic acid during shelf life.
●Daytime Capability: Due to its enhanced photo-stability and hydrophilic nature, it can be used during the day (when paired with SPF) to provide 24-hour collagen remodeling.
●Post-Procedure Recovery: It is exceptionally gentle, making it ideal for skin barrier repair and collagen maintenance following professional treatments like laser or microneedling.
6. The “Triple Threat” Synergy Strategy
PuriPharm’s NDS platform offers Universal Nano-Compatibility, allowing formulators to combine multiple nano-actives without risking physical instability or greasy textures.5A recommended high-performance matrix includes:
●NanoActive® RAL: Stimulates gene expression for collagen I and III synthesis.
●NanoActive® Silybin: A potent phyto-retinol that promotes regeneration while down-regulating pro-inflammatory cytokines to mitigate irritation .
●NanoActive® Hexylresorcinol: Reinforces the dermal support structure while inhibiting melanin for a unified, firm complexion.
7. Global Regulatory Compliance: EU 2024/996 Positioning
The latest EU Regulation 2024/996 restricts Retinol Equivalents (RE) to 0.3% for leave-on face products. This regulation heavily favors high-efficiency molecules like Retinaldehyde.
●Efficiency over Concentration: Because Retinaldehyde is 11x more active than Retinol, a 0.3% RAL concentration delivered via NanoActive® technology can provide anti-aging results comparable to unregulated 1.0%+ Retinol products from the past .
●Compliance Support: PuriPharm provides full in-vitro and clinical data to support “Anti-Wrinkle” and “Firming” claims under strict international labeling requirements.
Conclusion
The surge in demand for nano-encapsulated Retinaldehyde reflects a broader market return to technical excellence. PuriPharm’s NanoActive® delivery system does more than stabilize a volatile molecule; it simulates the biological effects of RF technology through a non-invasive, high-precision delivery platform. With its 31.05% reduction in wrinkle countand11x metabolic efficiency, NanoActive® RAL is not just a raw material—it is the strategic cornerstone for the next generation of “Clinic-at-Home” skincare.
Works cited
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Product Data Sheet: NanoActive Retinol
Manufacturer：PuriPharm Co., Ltd.
Product Name：NanoActive Retinol
Product Category：Stable, Water-soluble, High-absorption Vitamin A
1. Product Description
NanoActive Retinol is a novel preparation developed using a proprietary nano-delivery system. With a particle size ranging between 20-30 nm, this system effectively stabilizes Retinol within nano-carriers. This technology ensures deep skin penetration for maximum efficacy, controlled release, and significantly reduced irritation compared to conventional retinoic acid.
2. Product Identification (INCI)
- RETINOL (CAS #: 116-31-4)
- PHOSPHOLIPIDS (CAS #: 123465-35-0)
- CAPRYLIC/CAPRIC TRIGLYCERIDE (CAS #: 65381-09-1)
- GLYCERIN (CAS #: 56-81-5)
- WATER (CAS #: 7732-18-5)
3. Key Benefits & Efficacy
- Anti-Aging & Anti-Wrinkle: Stimulates collagen and elastin production; increases epidermal thickness and elasticity.
- Skin Renewal: Enhances cell turnover rate for smoother skin texture.
- Brightening: Inhibits tyrosinase expression and melanin synthesis to reduce pigmentation and even skin tone.
- Acne Care: Regulates sebum production and targets acne-causing bacteria (e.g., P. acnes).
- High Stability & Safety: Significantly improves Retinol stability and minimizes the irritation typically associated with Vitamin A derivatives.
- Enhanced Bioavailability: Nano-encapsulation ensures high absorption and effective penetration into skin layers.
4. Technical Specifications
4.1. Physical & Chemical Properties
4.2. Chemical Indexes
4.3. Microbiological Indexes
5. Application & Formulation Guidelines
- Recommended Usage: 0.1% – 1.0%
- Optimum pH Range: 4.5 – 8.0
- Application Method: Add to the formula during the final stage of production.
- Formulation Tips: * Primarily used in night care products.
- For daytime products, photoprotective agents must be added.
- Opaque packaging is highly recommended to protect the active ingredient.
6. Storage & Handling
- Preservatives & Antioxidants: Free from added preservatives and antioxidants.
- Storage Conditions: Store in original, unopened containers between and . Protect from direct sunlight and moisture.
- Shelf Life: 12 months from the date of manufacture under recommended conditions.
- Packaging: Standard plastic containers.
PuriPharm Co., Ltd.Address: 7th Floor, 6E Building, No. 1366 Hongfeng Road, Huzhou, Zhejiang, ChinaTel: 0572-2745768 | Email: service@puripharm.com