NanoActive r-RETINOATE

Posted on 04/17/202604/17/2026 by L, Y

NanoActive r-RETINOATE

8× retinol activity

Photostable • Non-irritating

A next-generation vitamin A derivative

Company Overview

PuriPharm Biopharmaceutical Technology Co., Ltd.

Delivering Beauty • Creating Value

Focused on the research and development of bioactives.

Specialized in the development of bioactive materials and functional ingredient systems.
Combines scientific delivery technology with application-oriented product design.
Dedicated to high-performance ingredients for beauty and personal care.

Nano Delivery Technology

One of the most widely studied and applied new formulation technologies.
Applicable across pharmaceuticals, foods, cosmetics and other fields.
Nano-bioactives are new products developed using nanodelivery systems.
Improves solubility, stability, irritation profile and odor while offering unique biological effects.

Fourth-Generation (4G) Cosmetic Ingredients

Clearly defined ingredients and content
Clearly defined targets
Clear mechanism of action
Formulations designed to preserve bioactivity
Good solubility
Stable and non-discoloring
Easy to absorb

A perfect combination of traditional medicine, modern biotechnology and nanotechnology.

Unique Occlusion Effect

Follicular Targeted Absorption

Nanocarriers accumulate efficiently around the hair follicle pathway.
This supports targeted delivery into deep skin appendages where actives can be retained and released.

Key takeaway：Hair follicles provide an efficient access route for targeted nano-delivery.

Smaller Particles Penetrate Deeper

and in Greater Amounts

Reduced particle size increases penetration depth in skin.
Smaller particles also increase the delivered amount of active ingredient.

The smaller the carrier, the deeper the penetration and the higher the delivery amount.

Follicular Reservoir Enables Slow Release for

More Than 10 Days

Hair follicles act as a storage reservoir for the active ingredient.
The active can be released gradually for more than 10 days after deposition.
This supports long-lasting efficacy with sustained local availability.

Long-lasting delivery：Slow release extends the activity window after follicular deposition.

Vitamin A：

A core scientific foundation for the product story

Functions of Vitamin A in the Human Body

Supports vision and visual signaling.
Contributes to growth, reproduction and immune support.
Involved in antioxidant defense, cell differentiation and gene transcription.

Vitamin A and Nobel Prizes

Vitamin A Is the Gold Standard in Anti-Aging Skincare

Common Vitamin A Actives Used in Skincare

Conversion to Retinoic Acid in Vivo

Why It Won the Award

2019 Ringier Technology Innovation Award

Vitamin A derivative suitable for daytime use
Safe and low irritation
Nano-encapsulation protects the active ingredient
A breakthrough and a new technical approach for retinoid raw materials

A distinctive retinoid concept that balances efficacy, stability and tolerability.

Unique Absorption Spectrum

Distinctive absorption profile
Efficient blue-light absorption
Good photostability

Product Introduction

Retinyl retinoate is obtained by esterifying the hydroxyl group of retinol with retinoic acid, while avoiding the application limits of retinol and retinoic acid in cosmetics.
NanoActive r-RETINOATE has an encapsulated particle size of 20–30 nm. This nanoemulsion size keeps the active stably suspended in the nanocarrier, enhances skin penetration and helps control the release rate.

Particle size：20–30 nm nano-encapsulation；

Delivery effect：Stable suspension, enhanced penetration and controlled release

Product Introduction

Skincare Benefits of Retinyl Retinoate

Efficacy Summary

Product Description

Formulation Guide

Suitable Products

Anti-aging products：

Maintains collagen in the dermis and helps prevent excessive collagen degradation.

When combined with hyaluronic acid and biocomposite polysaccharides (hydrolyzed myrtle), improvement in fine lines can be observed within one week.

Brightening products：

Works synergistically with vitamin C to inhibit tyrosinase, promote metabolism and accelerate fading of melanin.

The source deck notes that pairing with vitamin C is also effective for acne-prone skin.

Suitable Products

Sunscreen products：

Inhibits the UV-induced increase of MMP activity and helps protect elastic fibers and dermal collagen.

Improves wrinkles and fine lines caused by UV exposure.

Repair products：

Promotes endogenous hyaluronic acid synthesis and reduces skin TEWL.

Promotes keratinocyte activity and increases epidermal thickness, making the epidermis stronger.

NanoActive MN PRODUCT DATA SHEET

Posted on 04/16/202604/16/2026 by L, Y

Manufacturer: PuriPharm Co. Ltd.

1. Product Overview

NanoActive MN is an advanced, high-performance bioactive ingredient engineered specifically for premium skin and hair care formulations. Utilizing state-of-the-art nano-delivery technology, NanoActive MN features a specialized lipophilic tail that drastically improves skin penetration while minimizing the irritation and sensitization traditionally associated with unmodified nicotinic acid.

Once delivered into the skin, it undergoes targeted conversion into Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme that orchestrates cellular energy metabolism, DNA repair, and lipid synthesis, fundamentally reversing the age-related decline of skin and hair follicle vitality.

2. INCI & Chemical Information

INCI Name: Myristyl Nicotinate
Product Type: Nano-encapsulated Bioactive Agent

3. Technology Highlights

PuriPharm Co. Ltd. leverages proprietary core technologies to ensure maximum efficacy:

Nano Delivery System: Advanced nanotechnology ensures optimized bioavailability and targeted, deep-layer delivery of the active compound.
Enhanced Penetration: The lipophilic modification facilitates superior transepidermal transportation.
Targeted Action: Precisely targets local skin cells and hair follicles where esterase activity initiates the conversion process.
Improved Stability: Formulated to protect the active core, ensuring long-term shelf-life and robust compatibility within complex cosmetic matrices.

4. Mechanism of Action: The NAD+ Pathway

NAD+ levels natively decline by up to 50% by middle age, leading to compromised cellular repair and energy metabolism.

NanoActive MN effectively addresses this:

Enzymatic Cleavage: Upon penetration, native skin esterases selectively cleave the lipophilic tail of NanoActive MN.
Conversion: The molecule is efficiently converted into the active coenzyme NAD+ via cellular synthetic pathways.
Cellular Optimization: The synthesized NAD+ directly fuels mitochondrial energy generation, upregulates barrier lipid synthesis, and supports genomic (DNA) repair, combating oxidative stress and cellular senescence.

5. Proven Cosmetic Benefits & Efficacy Data

NanoActive MN has demonstrated remarkable results across comprehensive clinical andin vitroevaluations:

A. Profound Skin Barrier Repair

Visual & Structural Improvement: Clinical studies demonstrate a 250% improvement in barrier function on facial skin and an 11% improvement on the forearm volar surface (at 5% use level).
Epidermal Fortification: Induces a highly significant 70% increase in epidermal thickness (compared to a 13% increase in the control group).
Tight Junction Enhancement: Upregulates ZO-1 protein expression (3.38-fold relative expression at 0.04 mg/mL), physically reinforcing the skin barrier.

B. Anti-Aging & Cellular Renewal

Accelerated Renewal: Safely accelerates skin cell renewal by reducing Dansyl turnover time and increasing Minimal Erythema Dose (MED) without inducing photosensitivity.
Antioxidant Capacity: Exhibits excellent DPPH radical scavenging ability (6.10% maximum clearance at 0.3125%).

C. Hair Follicle Vitality & Anti-Hair Loss

Scalp Energy: Converts to NAD+ within the scalp, enhancing cellular ATP, stimulating follicle cell renewal, and actively neutralizing oxidative stress.
Clinical Hair Improvement: Well-designed clinical trials confirm significant improvements in hair abundance, density, hair shaft thickness, and overall hair quality with zero reported adverse effects.

D. Synergistic Efficacy with Retinoids

Retinol Companion: When formulated alongside retinoic acid or its derivatives, NanoActive MN acts as a potent buffer—significantly reducing retinoid-induced irritation and Transepidermal Water Loss (TEWL) while amplifying overall anti-aging efficacy.

6. Formulation Guidance & Compatibility

NanoActive MN is designed for seamless integration into modern cosmetic chemistry.

Suggested Use Level: 0.2% – 5.0%
Suitable Formulations: O/W and W/O Emulsion systems, Creams, Lotions, Serums, Essential Oils, Massage Oils, and Cleansing products.
Ingredient Compatibility: Exhibits excellent compatibility with a wide array of cosmetic raw materials including UV filters, emollients, humectants, natural oils, potent antioxidants, emulsifiers, thickeners, and retinoids. Minimal degradation is observed even in complex formulation matrices.

7. Recommended Applications

Advanced Facial Care: Anti-aging creams, barrier-repair lotions, and high-potency cellular regeneration serums.
Eye Care: Non-irritating eye creams and serums targeting fine lines and delicate skin reinforcement.
Hair & Scalp Care: Anti-hair loss treatments, scalp energizing tonics, and hair density serums.
Color Cosmetics: Functional lipsticks, lip glosses, eyeliners, and mascaras requiring bioactive support.

8. Storage, Stability, and Handling

Long-Term Stability: Demonstrates exceptional stability; viable for 24 months at room temperature in various formulations. Withstands accelerated stability testing (3 months at 40°C).
Storage Conditions: Store in a cool, dry environment between 4°C and 25°C. Protect from direct sunlight and moisture. Keep the original container tightly sealed when not in use.

Disclaimer:The information contained in this document is provided in good faith and is based on our current laboratory data and technical knowledge. It is intended for informational purposes only. Formulators are responsible for ensuring the stability, safety, and legal compliance of their final consumer products. PuriPharm Co. Ltd. makes no warranties, expressed or implied, regarding the use of this product.

The Paradigm Shift in Advanced Skincare: From Bioactive Ingredients to Bio-mimetic Delivery Systems

Posted on 04/05/202604/05/2026 by L, Y

Strategic Analysis of Nano-Encapsulated Retinaldehyde (NanoActive®RAL) as a High-Performance Alternative to Energy-Based Devices

1. The Evolution of Efficacy: Transitioning to “Clinical-Grade” Topical Solutions

The global skincare market is undergoing a fundamental shift from “Ingredient-Focused” (focusing on raw percentages) to “Science-Driven” (focusing on targeted delivery and bioavailability). A significant catalyst for this shift, particularly in the Asian and European markets, has been the 2024 regulatory tightening of home-use radiofrequency (RF) devices.As these devices are reclassified as medical instruments, a massive market gap has emerged for “RF-like” topical solutions capable of delivering measurable collagen-stimulating and skin-tightening results.

In this landscape,PuriPharm’s NanoActive® Retinal (RAL)delivery system has emerged as a premier commercial entry point. By leveraging pharmaceutical-grade nano-liposomes, PuriPharm addresses the historical “Triple Challenge” of Retinaldehyde: extreme instability, poor penetration, and high irritation potential.

2. Biochemical Logic: Why Retinaldehyde Outperforms Retinol

Vitamin A derivatives (retinoids) remain the gold standard in dermatology for stimulating the extracellular matrix (ECM). Their efficacy is determined by their proximity to Retinoic Acid in the metabolic pathway .

The “11x Efficiency” Factor

Traditional Retinol requires a two-step enzymatic oxidation to become active. In contrast, Retinaldehyde (RAL) is only one step away from Retinoic Acid. Scientific studies indicate that Retinaldehyde is approximately 11 times more efficientin bio-conversion than Retinol . This allows for significantly faster results in collagen synthesis, texture refinement, and wrinkle reduction even at lower concentrations .

3. NanoActive® Delivery System: Pharmaceutical-Grade Innovation

PuriPharm utilizes its proprietary Nano-Delivery System (NDS) to stabilize the “wild” nature of Retinaldehyde.

Ultra-Small Liposomal Architecture (<30nm)

NanoActive® RAL features a particle size precisely engineered to beunder 30nm (typically 20-30nm).This ultra-small scale, combined with a biomimetic phospholipid bilayer, provides two critical advantages:

1.Deep Dermal Penetration: The liposomal structure mimics skin cell membranes, allowing the active to bypass the stratum corneum and reach the deeper dermis more effectively than traditional emulsions.

2.“De-noising” Sustained Release: By encapsulating the RAL, the system provides a controlled release of the active. This “de-noising” process ensures a steady supply of energy to the skin while minimizing the common “Retinoid reaction” (redness, peeling, and stinging), making it suitable for sensitive skin types .

4. Clinical Evidence: Quantifiable Collagen Remodeling

The efficacy of PuriPharm’s NanoActive® RAL is substantiated by rigorous clinical testing. A 4-week independent human efficacy study conducted byIntertek (30 subjects, age 35-55) demonstrated the following results:

Instrument-Based Results (PRIMOS Analysis)

●Forehead Wrinkles: Count reduced by27.67%, total area reduced by11.98%.

●Crow’s Feet: Count reduced by31.05%, total area reduced by12.45%.

●Brightening (L Value)*: Significant increase in skin luminosity and ITA value, confirming a secondary whitening effect.

Subjective Satisfaction

●96.7% overall product satisfaction.

●93.3% of subjects reported visible improvements in skin firmness and elasticity.

●90.0% satisfaction regarding the reduction of fine lines under the eyes.

5. Innovation Highlight: NanoActive RETINAMIDE

For brands seeking “Day-to-Night” anti-aging solutions, PuriPharm has developed NanoActive RETINAMIDE, a stable amide derivative of retinoic acid conjugated with Polyethylene Glycol (PEG).

●Amide Bond Stability: Unlike HPR (Hydroxypinacolone Retinoate), RETINAMIDE is highly stable and does not hydrolyze into prohibited retinoic acid during shelf life.

●Daytime Capability: Due to its enhanced photo-stability and hydrophilic nature, it can be used during the day (when paired with SPF) to provide 24-hour collagen remodeling.

●Post-Procedure Recovery: It is exceptionally gentle, making it ideal for skin barrier repair and collagen maintenance following professional treatments like laser or microneedling.

6. The “Triple Threat” Synergy Strategy

PuriPharm’s NDS platform offers Universal Nano-Compatibility, allowing formulators to combine multiple nano-actives without risking physical instability or greasy textures.5A recommended high-performance matrix includes:

●NanoActive® RAL: Stimulates gene expression for collagen I and III synthesis.

●NanoActive® Silybin: A potent phyto-retinol that promotes regeneration while down-regulating pro-inflammatory cytokines to mitigate irritation .

●NanoActive® Hexylresorcinol: Reinforces the dermal support structure while inhibiting melanin for a unified, firm complexion.

7. Global Regulatory Compliance: EU 2024/996 Positioning

The latest EU Regulation 2024/996 restricts Retinol Equivalents (RE) to 0.3% for leave-on face products. This regulation heavily favors high-efficiency molecules like Retinaldehyde.

●Efficiency over Concentration: Because Retinaldehyde is 11x more active than Retinol, a 0.3% RAL concentration delivered via NanoActive® technology can provide anti-aging results comparable to unregulated 1.0%+ Retinol products from the past .

●Compliance Support: PuriPharm provides full in-vitro and clinical data to support “Anti-Wrinkle” and “Firming” claims under strict international labeling requirements.

Conclusion

The surge in demand for nano-encapsulated Retinaldehyde reflects a broader market return to technical excellence. PuriPharm’s NanoActive® delivery system does more than stabilize a volatile molecule; it simulates the biological effects of RF technology through a non-invasive, high-precision delivery platform. With its 31.05% reduction in wrinkle countand11x metabolic efficiency, NanoActive® RAL is not just a raw material—it is the strategic cornerstone for the next generation of “Clinic-at-Home” skincare.

Works cited

1.家用美容仪- MCR嘉世咨询, accessed April 3, 2026,

2.Retinal vs Retinol | Stabilization, Encapsulation & Claim Limits – Grand Ingredients, accessed April 3, 2026,

3.Platform Technology – PuriPharm, accessed April 3, 2026,

4.Anti acne oil control – PuriPharm, accessed April 3, 2026,

5.上海市化妆品行业广告宣传合规指引-广告监督管理, accessed April 3, 2026,

6.玻色因纳米视黄醛精华人体功效测试报告.pdf

7.NanoActive RETINAMIDE – PuriPharm, accessed April 3, 2026,

8.Bio-nest Biochemical Technology – Covalo, accessed April 3, 2026,

9.化妆品广告宣传合规指南-专业文章, accessed April 3, 2026,

Product Data Sheet: NanoActive Retinol

Posted on 03/27/202603/27/2026 by L, Y

Manufacturer：PuriPharm Co., Ltd.

Product Name：NanoActive Retinol

Product Category：Stable, Water-soluble, High-absorption Vitamin A

1. Product Description

NanoActive Retinol is a novel preparation developed using a proprietary nano-delivery system. With a particle size ranging between 20-30 nm, this system effectively stabilizes Retinol within nano-carriers. This technology ensures deep skin penetration for maximum efficacy, controlled release, and significantly reduced irritation compared to conventional retinoic acid.

2. Product Identification (INCI)

RETINOL (CAS #: 116-31-4)
PHOSPHOLIPIDS (CAS #: 123465-35-0)
CAPRYLIC/CAPRIC TRIGLYCERIDE (CAS #: 65381-09-1)
GLYCERIN (CAS #: 56-81-5)
WATER (CAS #: 7732-18-5)

3. Key Benefits & Efficacy

Anti-Aging & Anti-Wrinkle: Stimulates collagen and elastin production; increases epidermal thickness and elasticity.
Skin Renewal: Enhances cell turnover rate for smoother skin texture.
Brightening: Inhibits tyrosinase expression and melanin synthesis to reduce pigmentation and even skin tone.
Acne Care: Regulates sebum production and targets acne-causing bacteria (e.g., P. acnes).
High Stability & Safety: Significantly improves Retinol stability and minimizes the irritation typically associated with Vitamin A derivatives.
Enhanced Bioavailability: Nano-encapsulation ensures high absorption and effective penetration into skin layers.

4. Technical Specifications

4.1. Physical & Chemical Properties

4.2. Chemical Indexes

4.3. Microbiological Indexes

5. Application & Formulation Guidelines

Recommended Usage: 0.1% – 1.0%
Optimum pH Range: 4.5 – 8.0
Application Method: Add to the formula during the final stage of production.
Formulation Tips: * Primarily used in night care products.
For daytime products, photoprotective agents must be added.
Opaque packaging is highly recommended to protect the active ingredient.

6. Storage & Handling

Preservatives & Antioxidants: Free from added preservatives and antioxidants.
Storage Conditions: Store in original, unopened containers between and . Protect from direct sunlight and moisture.
Shelf Life: 12 months from the date of manufacture under recommended conditions.
Packaging: Standard plastic containers.

PuriPharm Co., Ltd.Address: 7th Floor, 6E Building, No. 1366 Hongfeng Road, Huzhou, Zhejiang, ChinaTel: 0572-2745768 | Email: service@puripharm.com

NanoActive® 7-DHC THE SKIN-NATIVE PROVITAMIN D PLATFORM

Posted on 03/17/202603/17/2026 by L, Y

Executive Overview

Science-Backed Innovation

PuriPharmis a leading specialist in the design and manufacture of high-functional cosmetic active ingredients and advanced delivery platforms.

Our mission is to empower global B2B customers with biologically meaningful solutions that translate complex cellular science into commercially successful skincare products.

PuriPharmBrand Framework

Why 7-DHC Matters

Endogenous Relevance

7-dehydrocholesterol (7-DHC) is a skin-native precursor produced naturally in the human epidermis.

As a key intermediate in the cholesterol biosynthetic pathway, it represents a truebiomimeticapproach to skin health, aligning with the skin’s inherent chemistry.

The Provitamin D Pathway

Homeostatic Skin Support

Translating Science to Beauty

The Delivery Advantage

The 7-DHC Innovation Platform

Beyond Traditional Actives

NanoActive® 7-DHC represents more than an ingredient—it is abiological platformfor brands seeking the next frontier in skin resilience.

By mimicking endogenous pathways, it offers a “Biology-First” marketing angle that resonates with sophisticated, research-driven consumers.

Mechanism of Action

Evidence Hierarchy

Polished Claim Map

Formulation Guidelines

Concept Applications

Target Consumer Needs

The Differentiation Edge

Commercial Strategic Value

Key Takeaways

Retinal (Retinaldehyde) Market Outlook & Strategic Analysis Report

Posted on 03/09/202603/09/2026 by L, Y

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I. Background:

The “EU Vitamin A Restriction” Shaking the Industry

The formal implementation of Regulation (EU) 2024/996 marks a pivotal regulatory turning point for Vitamin A derivatives in the skincare industry.

1. Key Regulatory Highlights

Concentration Thresholds: From November 1, 2025, new face and leave-on products must not exceed 0.3% Retinol Equivalent (RE); body lotions are limited to 0.05% RE.
Grace Period: Non-compliant products already on the market must be withdrawn by May 1, 2027.
Mandatory Labeling: Products must include a warning: “Contains Vitamin A. Consider your daily intake before use.”

2. Industry Ripple Effects

This regulation forces a paradigm shift from “High Concentration” to “High Efficiency.” Retinal (Retinaldehyde), the direct precursor to Retinoic Acid, has emerged as the premier alternative to Retinol, offering superior performance within the new legal limits.

II. Core Value:

Why Retinal is the “Optimal Solution”

Under the 0.3% concentration cap, Retinal provides a much higher “performance ceiling” compared to Retinol.

Conversion Efficiency: Retinal requires only one conversion step to become Retinoic Acid (the active form), whereas Retinol requires two. Research indicates Retinal’s bio-activity is approximately 10-11 times more efficient than Retinol.
Compliance Advantage: At the 0.3% EU limit, Retinal can deliver anti-aging results comparable to unregulated high-concentration Retinol (1.0%+) products of the past.
Antibacterial Benefits: Unlike Retinol, Retinal possesses natural antimicrobial activity, making it a unique solution for the “adult acne & anti-aging” dual-segment.

III. Technical Strategy:

Advanced Delivery & Synergistic Formulas

To overcome Retinal’s inherent instability, the following next-generation combinations are recommended:

1. Retinal + Silybin (Phyto-Retinol Strategy):

Silybin is highlighted as the premier plant-based Retinol alternative. It promotes collagen regeneration via “Retinoid-like” pathways without the irritation.
Its potent anti-inflammatory properties significantly down-regulate pro-inflammatory cytokines, mitigating the potential irritation often associated with Retinal.

2. Retinal + Hexylresorcinol (Multi-Target Aging):

Hexylresorcinol inhibits melanin synthesis while reinforcing the dermal support structure.
This synergy achieves a “1+1>2” effect for intensive wrinkle reduction and skin tone brightening.

IV. Core Competitive Advantages of PuriPharm

As a leader in Nano-Delivery Systems (NDS), PuriPharm is uniquely positioned to solve the stability and penetration challenges of Retinal:

1. Pharmaceutical-Grade Nano-Encapsulation (NanoActive®)

Solving Stability Issues: Retinal is extremely sensitive to light and oxygen. PuriPharm’s Nano-Liposome technology isolates the active from environmental factors, ensuring long-term potency.
Enhanced Skin Penetration: With particle sizes typically below 30nm, NanoActive® RAL (Retinal) penetrates the skin barrier more effectively than traditional formulations, reaching the deeper dermis.
Reduced Irritation (De-noising): Controlled release technology ensures a steady delivery of actives, minimizing the “Retinoid reaction” (redness and peeling).

2. Comprehensive Synergistic Ingredient Portfolio

PuriPharm provides a complete suite of nano-encapsulated actives, including NanoActive® RAL, NanoActive® Silybin, and NanoActive® Hexylresorcinol.
Universal Nano-Compatibility allows formulators to combine these “Triple Threat” ingredients seamlessly, ensuring physical stability and a premium, non-greasy skin feel.

3. Professional R&D & Data Support

● Backed by a founding team with deep pharmaceutical backgrounds, PuriPharm provides robust in-vitro and clinical efficacy data. This assists global brands in justifying their claims and navigating strict EU labeling requirements.

V. Strategic Opportunities for the International Market

“Concentration-to-Efficiency” Rebranding: Help brands leverage 0.3% Retinal Nano-products to outperform 1.0% Retinol competitors in efficacy.
Global Compliance Transition: Provide ready-to-use, EU-compliant ingredient solutions and stability dossiers for brands looking to enter or stay in the European market.
Custom NDS Development: Utilize the NDS platform to create exclusive “Retinal + X” nano-complexes, building a proprietary technical moat for the brand.

VI. Conclusion

The EU Vitamin A restriction is not an end, but the beginning of the “Era of Scientific Anti-Aging.” By utilizing PuriPharm’s Nano-Delivery Systems to master the stability and delivery of Retinal, brands can achieve market dominance in the post-retinol landscape.

NanoActive® RAL (Liposomal Retinal) Advanced Vitamin A Technology for High-Performance Skin Care

Posted on 02/13/202602/13/2026 by L, Y

Company & Brand Background

PuriPharm Co. Ltd. is a science-driven company specializing in the research, development, and commercialization of high-performance functional bioactive ingredients. With a strong foundation in pharmaceutical science, biotechnology, and advanced formulation technologies, PuriPharm is dedicated to delivering safe, effective, and innovative active ingredient solutions for the global cosmetics, personal care, and biomedical industries.

PuriPharm operates two core product platforms:

• PuriActives® – a portfolio of high-quality functional bioactives derived from natural, bio-based, and scientifically validated sources.

• NanoActive® – an advanced nano-delivery ingredient platform designed to enhance the stability, bioavailability, and efficacy of sensitive active compounds through cutting-edge encapsulation technologies.

NanoActive® RAL (Liposomal Retinal) is a flagship product of the NanoActive® series, representing PuriPharm’s expertise in vitamin A chemistry, lipid delivery systems, and skin bioavailability optimization.

Retinal, also known as retinaldehyde (RAL), is a highly active form of vitamin A and a direct biochemical precursor of retinoic acid, the biologically active molecule responsible for many of vitamin A’s well-known skin benefits.

Unlike retinol, which requires a two-step enzymatic conversion process in the skin, retinal converts to retinoic acid in only one step. As a result, retinal delivers faster and more efficient biological activity at significantly lower concentrations.

Scientific and clinical studies have demonstrated that:

• Retinal converts to retinoic acid approximately 11 times faster than retinol

• Retinal offers efficacy comparable to retinoic acid but with significantly improved skin tolerance

• Retinal provides powerful anti-aging, skin-renewing, and collagen-stimulating effects with reduced irritation

For these reasons, retinal is widely recognized as one of the most advanced and effective vitamin A forms available for modern skin care formulations.

Why Choose Retinal Instead of Retinol?

Although retinol has long been used in cosmetic formulations, it presents several inherent limitations, including instability, oxidation, discoloration, and slow biological conversion.

Retinal offers distinct advantages:

• Faster efficacy – 11-fold faster conversion to retinoic acid compared with retinol

• Higher biological efficiency – closer to retinoic acid in the vitamin A metabolic pathway

• Improved skin tolerance – lower irritation potential compared with retinoic acid

• Broader functionality – supports anti-aging, acne control, skin tone improvement, and barrier repair

However, retinal itself is a chemically sensitive molecule that is prone to oxidation, light degradation, and discoloration. These challenges have historically limited its widespread use in cosmetic formulations.

NanoActive® RAL: Liposomal Retinal Technology

NanoActive® RAL overcomes the traditional limitations of retinal through an advanced liposomal nano-delivery system, enabling formulators to fully unlock the benefits of retinal in a stable, effective, and user-friendly form.

NanoActive® RAL is a lipid-encapsulated retinal, engineered using phospholipid bilayer technology that mimics the structure of biological cell membranes. This delivery system provides comprehensive protection and controlled release of retinal in the skin.

Key Features of NanoActive® RAL

• High stability – protected from oxidation, light exposure, and thermal degradation

• No discoloration – maintains formulation clarity and color stability over time

• Enhanced skin absorption – liposomal structure improves penetration and bioavailability

• Controlled release – gradual delivery minimizes irritation while maximizing efficacy

• Superior compatibility – easy to formulate into a wide range of cosmetic systems

Through nano-encapsulation, NanoActive® RAL ensures that retinal remains active, effective, and safe throughout the product’s shelf life and during skin application.

11 Times Faster Conversion to Retinoic Acid

One of the most important advantages of NanoActive® RAL is the intrinsic metabolic efficiency of retinal.

In the skin:

• Retinol → Retinal → Retinoic Acid (two-step conversion)

• Retinal → Retinoic Acid (one-step conversion)

This simplified pathway allows retinal to deliver results approximately 11 times faster than retinol, leading to quicker improvements in skin texture, tone, and visible signs of aging.

Because NanoActive® RAL enhances retinal delivery and stability, this rapid conversion can occur more efficiently and consistently within the skin.

Skin Benefits of NanoActive® RAL

NanoActive® RAL delivers a comprehensive range of clinically supported skin benefits:

Anti-Aging & Wrinkle Reduction

• Stimulates collagen and elastin synthesis

• Improves skin firmness, elasticity, and density

• Reduces the appearance of fine lines and wrinkles

Skin Renewal & Texture Improvement

• Accelerates epidermal cell turnover

• Smooths rough skin texture

• Promotes a more even and refined complexion

Brightening & Tone Correction

• Inhibits tyrosinase activity and melanin formation

• Enhances skin radiance and uniformity

• Helps fade hyperpigmentation and discoloration

Acne & Blemish Control

• Exhibits direct antibacterial activity against acne-causing bacteria

• Regulates sebum production

• Supports pore refinement and blemish recovery

Barrier Support & Repair

• Improves skin barrier integrity

• Enhances resilience against environmental stressors

• Supports long-term skin health and comfort

Superior Stability and Color Performance

Traditional retinal and retinol formulations often suffer from:

• Rapid degradation

• Yellowing or browning over time

• Loss of activity during storage

NanoActive® RAL is specifically designed to address these issues. The liposomal encapsulation effectively isolates retinal from environmental stress factors, resulting in:

• Excellent formulation stability

• Minimal color change over time

• Consistent performance throughout shelf life

This makes NanoActive® RAL ideal for premium skin care products where visual appearance, product consistency, and long-term efficacy are critical.

Easy Absorption & Skin Compatibility

The phospholipid-based nano-carriers used in NanoActive® RAL closely resemble the lipid structure of human skin. This biomimetic design allows for:

• Improved skin affinity

• Efficient penetration through the stratum corneum

• Targeted delivery to deeper skin layers

As a result, NanoActive® RAL is easily absorbed, non-greasy, and well tolerated, even in long-term use formulations.

NanoActive® RAL is suitable for a wide range of cosmetic and personal care applications, including:

• Anti-aging serums and creams

• Brightening and skin renewal products

• Acne treatment formulations

• Eye care products

• Barrier repair and post-treatment care

Its excellent compatibility allows formulators to incorporate NanoActive® RAL into emulsions, gels, lotions, and advanced delivery systems with ease.

A New Generation of Vitamin A Actives

By combining the proven biological power of retinal with state-of-the-art nano-delivery technology, NanoActive® RAL represents a new generation of vitamin A active ingredients.

It offers:

• Faster results than retinol

• Better tolerance than retinoic acid

• Greater stability than conventional retinal

• Enhanced user experience and formulation reliability

Conclusion

NanoActive® RAL (Liposomal Retinal) embodies PuriPharm Co. Ltd.’s commitment to scientific excellence, innovation, and performance. As a key product within the NanoActive® platform and a natural extension of the PuriActives® philosophy, NanoActive® RAL provides formulators and brands with a powerful, stable, and advanced vitamin A solution for next-generation skin care.

By delivering stable, non-discoloring, easily absorbed liposomal retinal with an 11-fold faster conversion to retinoic acid compared with retinol, NanoActive® RAL sets a new benchmark for efficacy, safety, and formulation sophistication in modern cosmetic science.