PuriActives® BioFuco™ Powder

Posted on 09/24/202609/24/2026 by L, Y

PuriActives® BioFuco™ Powder

A Microbiome-Friendly Prebiotic Powder Blend

A tri-saccharide system for skin and scalp microbiome balance

INCI: Biosaccharide Gum-1 · Xylitol · Lactitol

Microbiome balance · Barrier & hydration · Smart powder format

Product Technology & Market Introduction · Cosmetic Active Ingredient

01 · SKIN ECOLOGY

The Next Logic of Skincare: Skin Is an Ecosystem

Skin is more than a physical barrier — it is an ecosystem built by microorganisms, sebum, water, and immune cells together. Resident flora occupy ecological niches, produce antimicrobial molecules, and “educate” the immune system: they are the first “living line of defense” of skin homeostasis.

When the flora falls out of balance (dysbiosis), dryness, sensitivity, breakouts, and dandruff follow — the answer is to restore balance, not to eliminate indiscriminately.

Dryness & flaking · Sensitivity & redness · Breakouts · Dandruff— all are scientifically linked to microbiome imbalance

106microorganisms / cm²Order of magnitude of microbial density on healthy skin

≈1,000bacterial species identified on human skinDiversity is closely tied to skin health

Sources: Grice & Segre, Nat Rev Microbiol, 2011; Byrd et al., Nat Rev Microbiol, 2018.

02 · WHY THE MICROBIOME

From “Killing” to “Nurturing”: The Shift Toward Microbiome Balance

Traditional Antimicrobial Logic｜KILL THEM ALL

Broad-spectrum antimicrobials remove microbes indiscriminately; resident and pathogenic flora are damaged alike; the ecological vacuum lets pathogens rebound faster; barrier and flora homeostasis are repeatedly disrupted.

Microbiome Balance Logic｜BALANCE THE ECOSYSTEM

Provide sugar substrates usable by resident flora; selectively limit pathogen adhesion and biofilms; restore the natural balance of niche competition; a better microenvironment builds a stronger barrier.

Sources: Byrd et al., Nat Rev Microbiol, 2018; Katsuyama et al., J Dermatol Sci, 2005.

03 · PRODUCT CONCEPT

BioFuco™ Powder: A Tri-Saccharide Prebiotic Active

Biosaccharide Gum-1｜A Fucose-Rich Polysaccharide

A fermentation-derived polysaccharide. Film-forming water lock for lasting hydration; soothing and skin-friendly with high skin affinity; enhances formulation sensory feel.

Xylitol｜A Prebiotic Five-Carbon Sugar Alcohol

A prebiotic pentitol. A selective substrate for resident flora; upregulates filaggrin to support the barrier; limits pathogen adhesion and biofilm formation.

Lactitol｜A Prebiotic Disaccharide Alcohol

A prebiotic disaccharide polyol. Selectively utilized by beneficial bacteria; a multi-hydroxyl hydrating structure; improves scalp and skin comfort.

Polysaccharide network × prebiotic sugar alcohols × microbiome modulation — not a simple blend, but a synergistic active system designed around the skin ecosystem.

PositioningMicrobiome-friendly activePrebiotic skin-conditioning system

Technical ProfileFermentation biotechnologyPreservative-free powder

04 · SYNERGY SYSTEM

The Tri-Saccharide System: One Synergistic Eco-Active

Microbiome Modulation

Selectively feeds resident flora while restraining opportunistic pathogens.

Barrier Support

Xylitol upregulates filaggrin and reduces TEWL.

Lasting Hydration

Film-forming + humectant sugars + endogenous NMF.

Soothing Comfort

The fucose-rich polysaccharide soothes sensitive, reactive skin.

The synergy logic is based on published research evidence for each component; see the evidence page and source notes.

05 · PREBIOTIC MODULATION

Selective Prebiotics: Feed the Residents, Restrain the Opportunists

Staphylococcus epidermidis

Resident flora · produces antimicrobial peptides · maintains homeostasis

1% xylitol significantly promotes growth; higher growth rate in pure culture (p < 0.001).

Staphylococcus aureus

Opportunistic pathogen · linked to atopic skin concerns · can form biofilms

5% xylitol significantly inhibits growth; growth suppressed in pure culture (p < 0.001).

Cutibacterium acnes

Common in sebum-rich areas · overgrowth linked to breakouts

5% xylitol significantly inhibits growth; both tested strains suppressed (p < 0.005–0.001).

Mechanism: xylitol is difficult for opportunistic pathogens such as S. aureus to ferment, yet can be metabolized by specific resident flora; it also inhibits S. aureus glycocalyx synthesis and biofilm formation — the essential difference between prebiotic modulation and broad-spectrum antimicrobial action. Lactitol is likewise selectively utilized by beneficial bacteria in microbiome models.

Sources: Anglenius et al., Korean J Microbiol, 2020 (in vitro, pure culture); Katsuyama et al., J Dermatol Sci, 2005; lactitol prebiotic evidence: Björklund et al., Age, 2012 (microbiome model).

06 · REBUILDING THE NICHE

Beyond Inhibition — Rebuilding a Resident-Dominated Niche

Selectivity Is Clear

The combination inhibits biofilm formation by opportunistic S. aureus by up to 64.7%, while affecting resident S. epidermidis by only < 2.5%.

Co-Culture Confirmation

The system reversed the growth advantage of S. aureus, restoring dominance to S. epidermidis — niche competition shifted back toward health.

In-Vivo Echo

A xylitol-containing cream applied to atopic dry skin significantly reduced S. aureus colonization and improved dryness within 4 weeks.

Source: Katsuyama et al., J Dermatol Sci, 2005 (Part 2, human study).

07 · SKIN BARRIER

Microbiome → Barrier → Skin Resilience

Human evidence: barrier support (14 days, n = 12, dry skin).

TEWL ↓TEWL significantly reduced; barrier function improved

Filaggrin ↑More filaggrin-positive epidermal cells (~25% vs. control)

Hydration ↑Stratum corneum hydration and biomechanics improved together

A 5% glycerol + 5% xylitol formula used for 14 days: TEWL fell significantly while skin hydration, epidermal and dermal thickness, and the DEJ undulation index all rose; in-vitro data identify xylitol as the key component upregulating filaggrin expression.

In an SLS acute-irritation human model, xylitol and glycerol showed dose-dependent anti-irritant and anti-inflammatory effects — direct evidence for sensitive-skin and compromised-barrier scenarios.

Sources: Korponyai et al., Acta Derm Venereol, 2017 (in vivo); Szél et al., J Eur Acad Dermatol Venereol, 2015 (in vivo).

08 · HYDRATION

A Triple Hydration Mechanism: Film · Humectancy · NMF

8hBiosaccharide Gum-1 hydration lasts 8 hours in human testingIngredient technical dossier (in-vivo volunteer study)

01 Film-Forming — a “Breathable Moisture Film”

The high-molecular-weight polysaccharide forms a non-occlusive moisturizing film on the skin surface, slowing water loss for immediate and long-lasting hydration with a silky, non-sticky feel.

02 Humectancy — Hydrogen-Bond “Water Capture”

The multi-hydroxyl structures of xylitol and lactitol bind water molecules through hydrogen bonds, raising stratum corneum water content and maintaining dynamic moisture balance even in dry environments.

03 Endogenous NMF — Upregulating Filaggrin

Xylitol upregulates filaggrin expression in keratinocytes — filaggrin breakdown products are the primary source of natural moisturizing factor (NMF), reinforcing hydration from within rather than relying on external humectants alone.

Sources: Korponyai et al., Acta Derm Venereol, 2017; Cohen et al., J Chem Soc Faraday Trans, 1993; Biosaccharide Gum-1 ingredient technical dossier (in vivo).

09 · SOOTHING & COMFORT

The Skin-Friendly Science of a Fucose-Rich Polysaccharide

Fucose is a natural component of human glycoproteins and glycolipids — skin “recognizes” Biosaccharide Gum-1, which is naturally highly affine and highly tolerated.

This makes it a time-proven soothing ingredient for sensitive and reactive skin care.

Sources: Biosaccharide Gum-1 ingredient technical dossier (in-vivo volunteer testing); Szél et al., J Eur Acad Dermatol Venereol, 2015 (in vivo); CIR Expert Panel safety assessment of microbial polysaccharide gums.

PART II · THE SMART POWDER FORMAT

From Liquid Actives to a Smart Powder

A more stable, more convenient, more efficient delivery form for a microbiome active

10 · WHY POWDER

Why a Powder: Five Pain Points of Liquid Actives, Solved One by One

Preservative-Free Format

Low water activity inhibits microbial growth, reducing reliance on preservatives.

Easy to Store

A solid form — simply sealed at room temperature; stable in long-term inventory.

Easy to Ship

Over 95% of water weight removed; built for global supply chains.

Easy to Handle

Free-flowing and non-caking; convenient to weigh and dose in both lab and production.

Easy to Disperse

Disperses quickly and evenly in the water phase; suitable for transparent formulas as well.

Traditional Liquid Actives	BIOFUCO™ POWDER
~97% water · requires a preservation system	Solid composite powder · low water activity by design
Heavy to ship · shelf life challenged by microbes	Light to ship · storage-friendly · flexible supply chain
Low-dose actives are hard to weigh precisely	Solid dilution ensures weighing and dispersion accuracy

The format comparison is based on the typical ~97% water content of liquid products in public technical literature; actual formulation performance should be verified.

11 · SMART SOLID DILUTION

Smart Solid Dilution: Every Milligram Under Precise Control

What It Means for Formulators

Accurate dosing: gram-scale handling with milligram-level precision.
Uniform dispersion: no local concentration spikes.
Non-caking: free-flowing and disperses instantly in water.
Scalable dosing: seamless scale-up from lab to production.
Standardized delivery: consistent active content from batch to batch.
High efficacy at low dose: a 1%–2% reference use level delivers the designed activity.

Use levels are reference ranges and should be optimized against formulation goals; the solid dilution process is a product design description.

12 · SCALP MICROBIOME

The Scalp: An Ecosystem That Also Needs Balance

The microbial fingerprint of dandruff: lipophilic Malassezia rises from 46% to 74%–83%, while resident C. acnes falls from 26% to single digits — dandruff is fundamentally a flora-imbalance problem.

The cascade of imbalance: dysbiosis accompanies elevated TEWL and pH plus a compromised scalp barrier, leading to dryness, itching, flaking, and scalp sensitivity.

A new care target: maintain scalp flora homeostasis and nourish the resident ecology — the next generation of scalp care beyond “aggressive anti-dandruff.”

13 · SCALP EVIDENCE

Xylitol × Lactitol: Evidence for Scalp Hydration and Barrier

Study Design

28 volunteers (16 women / 12 men) used a xylitol–lactitol wash-and-care regimen 3 times over 10 days — shampoo 1% + conditioner 1% + leave-on product 2%, against a placebo control.

Results

Scalp hydration rose +27% immediately and held at +17% on day 10; TEWL improved by -12.7% (trend); video microscopy showed regulated desquamation and stronger scalp barrier integrity.

Implication

By restoring scalp ecological balance — feeding beneficial flora and restraining harmful flora — dryness, itching, and dandruff discomfort are relieved at the source.

14 · SKINCARE APPLICATIONS

Skincare Applications: From Concept to Everyday Formulas

Microbiome Concepts

Microbiome skincare serums · prebiotic / postbiotic creams · post-cleansing microbiome care · flora-balancing lotions

Targeted Care

Soothing care for sensitive skin · barrier-repair creams · long-lasting hydrating serums and masks · microbiome care for blemish-prone skin

Gentle Scenarios

Gentle baby and child care · hydrating soothing mists · cleansers and rinse-off products · after-sun repair gels

Positioning: a microbiome-friendly active · a prebiotic skin-conditioning systemSuitable for leave-on and rinse-off systems; the water-soluble powder fits serums, creams, masks, mists, and cleansers.

Whether for a new “flora balance” concept launch or a sensitive-skin formula that pairs soothing with barrier support, BioFuco™ Powder delivers a clear scientific narrative and formulator-friendliness through a concise INCI combination.

15 · HAIR & SCALP CARE

From Scalp Ecology to Hair Condition

Scalp MicrobiomeBalanced scalp flora

Scalp BarrierScalp barrier integrity

Comfort & HydrationComfort and moisture

Healthy HairA healthy environment for hair

Typical Product Applications

Microbiome shampoos
Leave-on scalp serums
Soothing scalp mists
Conditioners and hair masks
Anti-dandruff support care
Products for sensitive scalps

Bonus: the film-forming property of Biosaccharide Gum-1 can remain on the hair fiber surface after rinsing, helping smooth the cuticle and enhance smoothness and shine (ingredient technical dossier).

16 · FORMULATOR-FRIENDLY

For Formulators: Usage Guide and Technical Notes

Item	Recommendation
Reference use level	0.5%–2.0% (reference range; optimize per formulation goals and efficacy positioning)
Phase of addition	Add to the water phase; ≤45°C for emulsion systems, room temperature for gels and aqueous systems
Dissolution & dispersion	Sprinkle slowly into the water phase under stirring; disperses and dissolves within minutes; pre-disperse and sieve for transparent formulas
pH suitability	4.0–8.0 (reference range; suits mildly acidic to neutral systems)
Compatibility & compliance	Good compatibility with common surfactants, thickeners, and preservation systems (reference); all three ingredients are IECIC-listed cosmetic raw materials; xylitol has been assessed by CIR

The above is a reference guide based on the ingredient’s public technical documentation and does not constitute precise process parameters; final formulation parameters should be confirmed through laboratory validation and stability testing.

17 · EVIDENCE CHAIN

The Evidence Chain: Mechanism → Evidence → Benefit

Mechanism	Key Evidence (Source · Level)	Cosmetic Benefit
Selective microbiome modulation	1% xylitol promotes S. epidermidis; 5% inhibits S. aureus / C. acnes — Anglenius et al., Korean J Microbiol, 2020 · in vitro	Microbiome-friendly concept
Anti-biofilm & niche rebuilding	Xylitol inhibits S. aureus glycocalyx and biofilms — Katsuyama et al., J Dermatol Sci, 2005 · in vitro + human; prebiotic blend inhibits S. aureus biofilms by up to 64.7% — Di Lodovico et al., Microorganisms, 2021 · in vitro	Blemish-prone and sensitive skin care
Barrier strengthening	Filaggrin expression up, TEWL significantly down (14 days, n=12) — Korponyai et al., Acta Derm Venereol, 2017 · human	Barrier repair
Triple hydration	Polysaccharide film hydrates for 8 hours — ingredient dossier · human; polyol hydrogen bonding to water — Cohen et al., 1993; filaggrin/NMF upregulation — Korponyai et al., 2017	Long-lasting hydration
Soothing & comfort	Post-challenge volunteer testing confirms soothing — ingredient dossier · human; dose-dependent anti-irritation in the SLS model — Szél et al., JEADV, 2015 · human	Sensitive-skin comfort
Scalp microbiome care	Scalp hydration +27% (immediate) / +17% (day 10), TEWL -12.7% (day 10, n=28) — PCT/IB2004/004345 patent-family clinical data · human	Scalp and hair care

In-vitro / dossier data ≠ finished-product clinical efficacy; third-party literature is for technical reference only and does not represent results for the BioFuco™ Powder finished formulation.

SUMMARY & CONTACT

Feed the beneficial flora. Balance the microbiome.

Microbiome BalanceFeed residents, restrain opportunists	Barrier SupportFilaggrin · TEWL · NMF	HydrationFilm + humectancy + NMF
Skin ComfortSoothing for sensitive skin	Scalp CareBacked by clinical evidence	Smart Powder FormatPreservative-free · easy to use

PuriActives® BioFuco™ Powder — the prebiotic powder for skin and scalp microbiome balance

PURIPHARM CO., LTD.

www.puriactives.com · service@puripharm.com · +86-572-2745768Building 6, No. 1366 Hongfeng Road, Huzhou, Zhejiang, China

This material is for cosmetic ingredient introduction only and does not constitute pharmaceutical claims; in-vitro and ingredient dossier data are not equivalent to finished-product clinical efficacy; cited third-party literature is for technical reference only. PuriActives® and BioFuco™ are trademarks of PURIPHARM CO., LTD.

PuriVitin® S100 The Moisture Magnet

Posted on 08/18/202608/18/2026 by L, Y

SACCHARIDE ISOMERATE · MOISTURE MAGNET

72-Hour Long-Lasting Deep Hydration · High-Assay Powder · Preservative-Free · Skin-Identical Technology

PuriPharm Co. Ltd. · Huzhou, China · www.puriactives.com

CONTENTS

Agenda

PRODUCT PRESENTATION

01 Insight The unmet need in skin hydration

02 Science Magnet-like binding mechanism & proven efficacy

03 Advantage Why the powder format

04 Application & Specification Formulation guide · Technical specs · Quality assurance

CHAPTER 01 · INSIGHT Hydration, the First Principle of Skincare Among all skincare claims, hydration is the most fundamental — and the least perfectly solved. Water must not only be delivered, but retained.

01 · INSIGHT

Why Traditional Humectants Never Truly Stay

① Glycerin & Polyols Passive hygroscopicity depends on ambient humidity and drops sharply in dry air; higher doses turn sticky while water still escapes fast.

② Hyaluronic Acid High-MW molecules sit on the surface forming a film rather than penetrating the stratum corneum — largely removed by a single wash.

③ Ordinary Sugar Humectants Lacking skin affinity, they merely rest on the surface; in rinse-off formats they are flushed away almost completely.

The market needs not more water — but water that stays.HYDRATION THAT STAYS, NOT JUST HYDRATION

Sources: Flychem, Saccharide Isomerate Formulation Guide; public technical literature

PuriActives® PuriVitin S100 · The Moisture Magnet

A Small Sugar, Skin-Identical by Nature

INCI Name：Saccharide Isomerate

CAS No.：100843-69-4

Origin：Saccharide complex obtained by isomerization of plant-derived carbohydrates

Composition：A blend of mono- and disaccharides, similar in composition to the sugars of skin NMF

Mol. Weight：120 – 400 Da

Appearance：Pale yellow to white powder, characteristic odor

SKIN-IDENTICAL：Highly similar to the sugar complex of the skin’s own NMF — not a foreigner, but one of our own.

Skin identity means inherent biocompatibility and mildness — the structural basis of lasting hydration.

Sources: CIR Safety Assessment of Saccharide Humectants; PuriPharm PuriVitin S100 Product Specification

PuriActives® PuriVitin S100 · The Moisture Magnet

CHAPTER 02 · SCIENCE It Clings to Skin, Like a Magnet A unique binding mechanism turns hydration from a surface act into deep retention — bind, retain, stay: a three-step loop of lasting moisturization.

02 · MECHANISM

Magnet-Like Binding: A Three-Step Loop

01 · Magnetic Binding · BIND The sugar complex forms hydrogen bonds with the ε-amino groups of lysine in keratin, anchoring itself into skin rather than sitting on it.

02 · Water Reservoir · RESERVOIR Bound sugars continuously attract and lock in water, building a lasting moisture reservoir within the stratum corneum — instant and deep.

03 · Long-Term Stay · STAY The bond cannot be washed off; it is removed only by natural desquamation, keeping skin hydrated for 72 hours and beyond.

CANNOT BE WASHED OFF — REMOVED ONLY BY NATURAL DESQUAMATION

02 · EFFICACY

72 Hours of Deep, Long-Lasting Hydration

72h LONG-LASTING DEEP HYDRATION A single application creates a moisture reservoir for instant, deep hydration that persists for 72 hours — even through daily cleansing routines.

3h：Instant boost on extra-dry areas Perceptible hydration of the driest facial zones within 3 hours

28d：True hydration across all facial areas Daily use steadily improves hydration of every facial zone over 28 days

+275%：Skin moisture increase after one use In-vivo body-lotion study: +275% skin moisture after a single application

75%：Softer skin, no tightness — self-assessed 0.2–0.5% shower gel, skin still hydrated after 7 days of frequent washing

Beyond Hydration: Barrier Repair & Soothing

50%+Smoother Clinical scoring shows over 50% improvement in smoothness and softness after only 2 weeks, with flakiness and itch reduced by more than half.

2×：Faster barrier recovery vs control In-vivo study: more than 2× the barrier repair rate, 24 hours ahead of a leading benchmark

2×：Redness relief 2× the benchmark Significant soothing of dryness-induced redness and sensitivity — ideal for sensitive-skin formulas

24h：24-hour soothing for body skin Relieves dryness from frequent washing, sanitizers and daily cleansing stress

Strengthening the skin’s own defense, cutting water loss at the source — this is what moisture retention truly means.

Activating Skin’s Own Hydration Program

PuriVitinS100

Filaggrin ↑ NMF SYNTHESIS Elevates NMF levels, strengthening the water-holding power of the stratum corneum

Hyaluronan Synthase-3 (HAS-3) ↑ ENDOGENOUS HA Stimulates endogenous hyaluronic acid production — moisture from within

Loricrin ↑ BARRIER STRUCTURE Reinforces the cornified envelope for a more complete barrier architecture

Acid Sphingomyelinase (ASM) ↑ CERAMIDES Boosts ceramide synthesis, replenishing intercellular lipids to curb water loss

More than external hydration — it awakens the skin’s own moisture system, inside and out.

02 · COMPARISON

A Fundamental Difference from Classic Humectants

Dimension	PuriVitin S100	Glycerin	Hyaluronic Acid
Mechanism	Hydrogen-bonded to keratin — becomes part of the skin	Surface hygroscopicity, humidity-dependent	Surface film-forming occlusion
Wash Resistance	Cannot be washed off; removed only by natural desquamation	Easily rinsed away	Largely removed by washing
Longevity	72-hour continuous deep hydration	Hours only; needs reapplication	Short-term surface hydration
Barrier Care	Upregulates barrier genes, reduces TEWL	Indirect, limited	Mainly occlusive film

Glycerin and hyaluronic acid are water passing through; the Moisture Magnet is water that moves in.

Sources: CIR Safety Assessment; Flychem Formulation Guide

PuriActives® PuriVitin S100 · The Moisture Magnet

CHAPTER 03 · ADVANTAGE Why the Powder Format? The same magnet, in its purest form — higher assay, lighter load, and benefits that run from plant to formula.

03 · POWDER ADVANTAGES

S100 Powder: Five Core Advantages

01 · High Assay Dry powder with moisture ≤10% — actives far above a standard 50% aqueous grade, so less goes further

02 · Easy Logistics No water weight: far lighter and smaller shipments at ambient 4–25°C storage — lower freight and warehousing costs

03 · Easy Handling Precise weighing and dosing; fits aqueous, emulsion, anhydrous and powder formats alike

04 · Preservative-Free Low water activity naturally suppresses microbial growth — no preservatives needed in the raw material

05 · Proven Safety CIR safety assessment: low toxicological risk, non-sensitizing — decades of safe use worldwide

≤10% MOISTURE CONTENT · 36 SHELF LIFE (MONTHS) · 0 PRESERVATIVES ADDED

03 · POWDER VS LIQUID

Powder Grade vs Standard Aqueous Grade

Dimension	PuriVitin S100 Powder	Standard 50% Aqueous Grade
Active Content	High (moisture ≤10%)	Approx. 50%
Recommended Dose	0.2 – 1.0% (leave-on)	1 – 3%
Preservation	No preservatives required	Water-based: microbial control needed
Storage & Shipping	Ambient, lightweight, compact	Roughly 2× weight and volume
Microbial Risk	Low water activity, low risk	Relatively higher
Suitable Systems	Aqueous / emulsion / anhydrous / powder	Aqueous / emulsion

Note: Aqueous-grade figures are general references from public technical literature of the same INCI; please refer to each supplier’s TDS. Dosage conversion is based on active content.

Sources: Flychem, Saccharide Isomerate grade comparison guide; PuriPharm Product Specification

PuriActives® PuriVitin S100 · The Moisture Magnet

04 · APPLICATION

Formulation Guide

Solubility Readily water-soluble; add to the water phase — pre-dispersing in a little water avoids clumping

Process Suitable for cold and hot processing; keep heated stages below 60°C

pH Range Stable across a wide pH window (ref. 4–10), including high-pH soap bases

Dosage Leave-on 0.2 – 1.0%; rinse-off 0.2 – 0.5% (powder grade, active-adjusted)

Compatibility Synergistic with glycerin, hyaluronic acid, ceramides and niacinamide; works as a hydration booster for glycerin

APPLICATIONS Head-to-Toe Formats• Facial serums · ampoules · toners • Creams · lotions · eye care • Masks · lyophilized powders · anhydrous • Body lotion · hand cream · after-sun • Shampoo · conditioner · scalp care • Cleansers · shower gels · bar soaps

04 · SPECIFICATION

Technical Quality Standard

Category	Item	Specification	Unit
Physico-chemical	Color	Pale yellow to white	—
	Odor	Characteristic	—
	Aspect	Powder	—
	Moisture	≤ 10	%
	Refractive index (50% aq., 25°C)	1.42 – 1.43	—
Safety & Micro	Heavy Metals	≤ 20	ppm
	Aerobic Plate Count	≤ 1000	CFU/g
	Escherichia coli	Negative	—
	Salmonella	Negative	—
Storage & Pack	Shelf Time	36	months
	Storage Temperature	4 – 25	°C
	Storage & Packaging	Cool, dry, sealed, protected from light; plastic container	—

Source: PuriPharm Co. Ltd., PuriActives® PuriVitin S100 Product Specification (revision date: 2024-12-02), approved by the Manager of Quality Control.

PuriActives® PuriVitin S100 · The Moisture Magnet

04 · QUALITY & COMPLIANCE

Global Compliance, Traceable Quality

Rigorous Quality Control Batch release testing with internal heavy-metal and microbial limits stricter than industry norms; COA supplied with every lot

Compliant in Major Global Markets INCI listed; compliant with EU Regulation (EC) No 1223/2009; hundreds of products reported in the US FDA VCRP; the same INCI holds quasi-drug additive status in Japan

Authoritative Safety Endorsement US CIR safety assessment: low toxicological risk, non-sensitizing; leave-on use recorded up to 2.8%, with decades of safe application

REFERENCES References & Data Sources1. CIR. Safety Assessment of Saccharide Humectants as Used in Cosmetics. 2021 2. DSM-Firmenich. PENTAVITIN® official product information (same INCI) 3. Happi. DSM Pentavitin Provides Deep Hydration for Skin and Hair Care. 2011 4. DSM. Rinse-off in-vivo efficacy studies. Personal Care, 2021 5. Flychem. Saccharide Isomerate formulation guide 6. PuriPharm Co. Ltd. PuriVitin S100 Product Specification, 2024 Note: Items 2–5 are public studies of the same INCI (Saccharide Isomerate). Efficacy claims should be validated in the final formulation.

PURIACTIVES® BY PURIPHARM Every gram of your formula, holding on to water. HYDRATION THAT STAYS — PURIVITIN S100 PuriPharm Co. Ltd. No. 1366 Hongfeng Road, Huzhou, Zhejiang, China Tel +86-572-2745768 · service@puripharm.com www.puriactives.com This document is provided in good faith for formulation reference only; suitability testing and regulatory compliance remain the user’s responsibility.

PuriActives® SupraSalix Supramolecular Salicylic Acid

Posted on 06/13/202606/13/2026 by L, Y

Technical Dossier | PuriPharm Co. Ltd. —— A Breakthrough 3-in-1 Targeted Solution: Sebum Control • Barrier Repair • Microbiome Balance

1. Product Overview

Traditional Salicylic Acid (SA) is highly efficacious in anti-acne and sebum control treatments. However, its free-acid form is notoriously associated with adverse effects, including severe irritation, flaking, and disruption of the skin barrier. To address this persistent industry challenge, PuriPharm Co. Ltd. has engineered PuriActives® SupraSalix (Supramolecular Salicylic Acid), specifically designed for modern sensitive skin and compromised complexions.

Powered by cutting-edge supramolecular self-assembly technology, PuriActives® SupraSalix utilizes a core of Salicylic Acid and Zinc Amino Acid. It innovatively integrates the biomimetic repair network of Xyloglucan and the prebiotic engine of α-Glucan Oligosaccharide.

This active ingredient shatters the traditional paradigm that “anti-acne equals barrier damage.” By achieving a 4D synergistic effect—sustained-release desensitization, comedolytic sebum control, biomimetic repair, and microbiome balance—it stands as a next-generation, ultra-mild anti-acne active formulated for sensitive skin, acne vulgaris, and seborrheic dermatitis.

2. Core Components & Mechanism of Action

The exceptional efficacy of PuriActives® SupraSalix originates from its meticulously designed matrix of four core components:

2.1 The Core Anti-Acne Engine: Salicylic Acid & Zinc Amino Acid

A supramolecular network cleverly conjugates Salicylic Acid with Zinc Amino Acid (primarily Zinc Glycinate) to achieve “reduced toxicity, enhanced efficacy” alongside kinetic sustained release.

Salicylic Acid: A lipophilic BHA that penetrates deep into hair follicles to dissolve keratin plugs and sebum, exerting potent comedolytic action. Simultaneously, it inhibits COX enzyme activity to block the production of pro-inflammatory mediators like prostaglandins.
Zinc Ion: An essential trace element. It inhibits 5α-reductase activity, significantly reducing sebum hypersecretion at the source. It also disrupts pathogenic biofilms for broad-spectrum antimicrobial action while accelerating wound healing and tissue remodeling.
Amino Acid (e.g., Glycine): The smallest amino acid. It not only acts as a carrier to enhance Zinc’s skin penetration but is also a critical component of the Natural Moisturizing Factor (NMF) and collagen, effectively soothing localized dryness caused by acid peeling.

2.2 The Invisible Biomimetic Barrier: Xyloglucan

A natural polysaccharide extracted from Tamarind seeds, widely recognized in pharmaceutical applications for treating eczema, dermatitis, and psoriasis.

“Second Skin” Effect: Exhibits outstanding film-forming properties, creating a breathable, invisible biomimetic shield on the skin surface to defend against external aggressors (e.g., PM2.5, allergens).
Deep Hydration & Repair: Significantly reduces Transepidermal Water Loss (TEWL), providing a moist healing microenvironment for a compromised stratum corneum. It synergizes with amino acids to accelerate barrier repair and diminish erythema (redness) and acne marks.

2.3 The Microbiome Modulator: α-Glucan Oligosaccharide

A highly active, plant-derived prebiotic.

Targeted Feeding: Selectively promotes the proliferation of beneficial skin flora (e.g., Staphylococcus epidermidis) while remaining indigestible to pathogens (e.g., Cutibacterium acnes, Malassezia).
Competitive Inhibition: By robustly cultivating beneficial bacteria to occupy the ecological niche, it competitively inhibits the microorganisms responsible for acne and seborrheic dermatitis, cutting off the root cause of recurrent breakouts from an ecological standpoint.

3. 4D Synergy Matrix

PuriActives® SupraSalix is not a simple physical blend. Through PuriPharm’s supramolecular technology, it establishes a 1+1+1>3 synergistic network:

1D Clear & Control: SA pore unclogging + Zinc’s active sebaceous inhibition. A dual-action approach to drastically improve oily skin and congested pores.
2D Targeted Anti-inflammatory: Zinc (inhibiting the upstream NF-kB pathway) combined with SA (inhibiting the downstream COX pathway). Delivers rapid erythema reduction and soothes inflamed papules.
3D Biomimetic Repair: Xyloglucan’s physical film-forming + Amino acid’s biochemical hydration. Perfectly neutralizes the harsh peeling effects of acids, enabling simultaneous “Clear & Repair.”
4D Microbiome Balance: α-Glucan Oligosaccharide reconstructs the microbial barrier, complementing the antimicrobial properties of Zn and SA. It systematically improves acne-prone and reactive skin profiles, preventing future relapses.

4. Core Advantages vs. Benchmark

5. Applications & Formulation Guidelines

PuriActives® SupraSalix demonstrates exceptional compatibility and solubility, making it highly versatile for various cosmetic formats including toners, serums, emulsions, gels, and wash-off products.

Primary Application Scenarios:

Professional Acne/Comedone Care: Anti-acne serums, spot treatment gels, chemical peel solutions (highly recommended for sensitive skin peeling).
Sebum & Pore Management: Pore-refining toners, mattifying/balancing emulsions, deep-cleansing mud masks.
Seborrheic Dermatitis & Scalp Care: Anti-dandruff shampoos, scalp oil-control serums, scalp microbiome treatments.
SOS Redness & Repair Care: Post-extraction soothing treatments, anti-inflammatory products for barrier-compromised phases.

Formulation Guidelines:

Appearance: (Please refer to the actual product COA)
Solubility: Excellent water solubility; easily incorporated into the aqueous phase.
Recommended Dosage: 1.0% – 5.0% (Depending on specific product claims and efficacy substantiation).
Optimal pH Range: 4.0 – 6.5 (A mildly acidic environment favors the stability of the supramolecular network and SA activity. Strongly alkaline environments should be avoided).
Compatibility: Pairs excellently with active ingredients such as Niacinamide, Hyaluronic Acid, and Ceramides. Note: Avoid prolonged co-existence with high concentrations of strong metal chelating agents (e.g., EDTA) in the same system to prevent competitive disruption of the Zinc complex structure.

Copyright Statement: PuriActives® is a registered trademark of PuriPharm Co. Ltd. The information provided in this document is based on current scientific research and in vitro / in vivo testing, intended solely as a reference for formulators and R&D professionals.

NanoActive 4-TERPINEOL: The Pure Power of Tea Tree, Delivered with Nano-Precision

Posted on 05/25/202605/25/2026 by L, Y

1. Product Overview

NanoActive 4-TERPINEOL is a highly purified, nanostructured lipid carrier (NLC) encapsulated formulation of 4-Terpineol, the most potent and functional active ingredient naturally found in Melaleuca alternifolia (Tea Tree) oil.

By isolating the highly active 4-Terpineol and utilizing PuriPharm’s proprietary NanoActive™ Delivery Technology, we have created a next-generation active ingredient. It offers exceptional broad-spectrum antimicrobial and anti-inflammatory properties while completely bypassing the classical limitations of traditional essential oils, such as poor water solubility, high volatility, pungent odor, and skin sensitization.

INCI Name: 4-Terpineol, Phospholipids, Glycerin, Water

Appearance: Opalescent to translucent liquid

Recommended Usage: 1.0% – 5.0%

2. The Challenge & The PuriPharm Solution

The Limits of Conventional 4-Terpineol

While 4-Terpineol is scientifically proven to be vastly superior to whole Tea Tree Oil in targeting Cutibacterium acnes and Demodex mites, its use in cosmetic formulations has been severely hindered:

Formulation Incompatibility: Highly lipophilic and totally insoluble in water.
Sensory Issues: Strong, characteristic medicinal odor that is difficult to mask.
Instability: Prone to volatilization and oxidation during storage.
Irritation: High concentrations can compromise the skin barrier and cause erythema.

The NanoActive™ Breakthrough

PuriPharm has engineered a sub-micron encapsulation system (particle size: 10nm – 100nm). The active 4-Terpineol is safely enclosed within a biocompatible phospholipid bilayer.

Total Water Solubility: Transforms a highly lipophilic compound into an easily dispersible, clear aqueous system.
Odor Masking: The lipid encapsulation significantly reduces the characteristic terpene odor, allowing for elegant, fragrance-free formulations.
Targeted Follicular Delivery: The lipophilic nature of the nanocarrier ensures targeted accumulation in the pilosebaceous unit, precisely where C. acnes and sebum reside.
Sustained Release & Zero Irritation: Controlled release kinetics prevent immediate spikes in local concentration, minimizing irritation and extending efficacy.

3. Mechanism of Action & Efficacy

A. Broad-Spectrum Antimicrobial & Anti-Parasitic Activity

NanoActive 4-TERPINEOL acts directly on the microbial cell membrane, disrupting its integrity without inducing bacterial resistance.

Acne Management: Exhibits a remarkably low Minimum Inhibitory Concentration (MIC) against Cutibacterium acnes and Staphylococcus aureus.
Scalp & Dandruff: Highly effective against Malassezia furfur, balancing the scalp microbiome.
Rosacea & Demodex: A proven, potent agent for paralyzing and eradicating Demodex folliculorum (face mites), a key trigger for rosacea and adult acne.

B. Immunomodulation & Inflammation Reduction

Beyond microbial control, 4-Terpineol actively suppresses the production of pro-inflammatory mediators. It inhibits the release of cytokines such as TNF-α, IL-1β, IL-8, and PGE2 from activated monocytes, rapidly reducing the clinical signs of inflammation, erythema, and swelling associated with acne lesions.

4. Cosmetic Applications

NanoActive 4-TERPINEOL is a versatile, high-performance active suitable for a wide range of dermatological and personal care applications:

Anti-Acne & Blemish Control: Serums, spot treatments, and purifying toners.
Sensitive Skin & Rosacea Care: Soothing lotions and barrier-repair creams.
Advanced Scalp Care: Anti-dandruff shampoos and scalp-purifying treatments.
Intimate Care: Gentle, pH-balanced washes for microbiome control.
Men’s Grooming: Aftershave balms to prevent folliculitis.

5. Formulation Guidelines

PuriPharm guarantees ease of use for formulators:

Solubility: Readily dispersible in water and cold-processable.
Process: Can be added directly to the aqueous phase or at the end of the formulation process (<45°C).
pH Stability: Stable across a broad pH range (4.0 – 7.0).
Compatibility: Highly compatible with standard cosmetic ingredients, including AHA/BHAs, niacinamide, and typical rheology modifiers.

PuriPharm Co. Ltd. Innovating the Future of Active Delivery.

Pioneering the Future of Skincare Efficacy

Posted on 05/19/202605/19/2026 by L, Y

At PuriPharm, we bridge the gap between advanced biomedical science and transformative cosmetic solutions. As a leading innovator in active ingredients and delivery architectures, we empower global personal care brands to achieve unprecedented clinical efficacy. Our core philosophy is built on two pillars: extracting the absolute potential of bioactive molecules, and ensuring their precise delivery to the target site.

Our Core Technology Matrix

PuriPharm’s innovation engine is driven by two flagship platforms, designed to work independently or in powerful synergy to elevate your formulations.

1. PuriActives®: The Pinnacle of Biological Efficacy

PuriActives® represents our premier line of highly purified, biologically active compounds. Rooted in synthetic biology, advanced fermentation, and precision extraction technologies, the PuriActives® portfolio delivers potent, mechanism-driven ingredients.

Uncompromised Purity: Rigorous isolation processes ensure that only the most active molecules are retained, minimizing impurities and maximizing safety.
Mechanism-Driven: Each active is developed with a clear understanding of cellular pathways, offering targeted solutions for anti-aging, pigmentation control, skin barrier repair, and microbiome balance.
Sustainable Sourcing: Inspired by nature and optimized in the lab, we minimize ecological impact while delivering consistent, scalable results.

Key Applications: Bio-mimetic Peptides, Recombinant Proteins, High-purity Botanical Extracts.

2. NanoActive®: Precision Delivery, Amplified Performance

The most potent active ingredient is only as effective as its ability to reach its target. NanoActive® is our proprietary, state-of-the-art nanotechnology delivery platform, engineered to overcome the thermodynamic and physiological barriers of the stratum corneum.

Enhanced Bioavailability: Utilizing advanced liposomal, solid lipid nanoparticle (SLN), and nano-emulsion architectures, NanoActive® dramatically increases the solubility and skin penetration of challenging active molecules.
Controlled & Sustained Release: Our carrier systems are designed for spatio-temporal precision, releasing the actives gradually to ensure long-lasting efficacy and lower irritation profiles.
Formulation Stability: By encapsulating sensitive compounds (e.g., Retinol, Vitamin C, Resveratrol), NanoActive® shields them from oxidation, light, and formulation incompatibilities, extending product shelf life.

The Science of Delivery: Nanostructured Lipid Carriers (NLC), Multi-lamellar Liposomes, Micro-sponges.

The Synergy of Science and Business

At PuriPharm, we do more than supply ingredients; we provide architectural solutions for your formulations. Whether you require the potent biological triggers of PuriActives® or the sophisticated delivery mechanisms of NanoActive®—or a customized integration of both—our team of scientists and market experts is ready to co-create your next hero product.

PuriPharm Co. Ltd. Innovating Molecules. Architecting Delivery. Transforming Beauty.

NanoActive® BAICALIN

Posted on 05/19/202605/19/2026 by L, Y

A New Era in Telomerase-Targeted Anti-Aging: Ultimate Repair at the Cellular Core

PURIPHARM: PIONEERS IN DELIVERY INNOVATION

Leading the “Transdermal Delivery” Revolution

PuriPharm is dedicated to the efficient delivery of biological active ingredients. The NanoActive® platform, driven by our proprietary NDS (Nano Delivery System) technology, overcomes the traditional limitations of active compounds regarding stability, solubility, and permeability.

Focus on nano-encapsulation of bioactives.

Pharmaceutical-grade R&D and manufacturing standards.

Empowering premium global cosmetic brands.

BAICALIN: NATURE’S “LONGEVITY FACTOR”

Modern Science from Traditional Medicine

Extracted from the roots of Scutellaria baicalensis, Baicalin is widely recognized in dermatology as a highly potent, multi-functional active ingredient. Extensive SCI research confirms its superior performance in delaying cellular senescence, neutralizing free radicals, and repairing UV damage.

Key Profile: A high-purity flavonoid compound and a natural telomerase activator.

TRADITIONAL CHALLENGES: FORMULATION BOTTLENECKS

THE NANOACTIVE® SOLUTION

Driven by Molecular Motor Technology

NanoActive® BAICALIN utilizes ATP synthase molecular motor technology to encapsulate active molecules within biological microcapsules that highly simulate cellular membrane structures.

Particle Size: 10-100nm, increasing transdermal delivery by 500%.

Stability: Enhances anti-oxidative degradation capacity by more than 10 times.

Solubility: 100% highly water-soluble for crystal-clear formulations.

Core Mechanism: Molecular Targeted Repair

TELOMERASE: THE “BIOLOGICAL CLOCK”

Breaking the Hayflick Limit

Telomeres are protective caps located at the ends of chromosomes that shorten with each cell division. Once telomeres are depleted, the cell enters a state of irreversible “Senescence”.

Telomerase is the only crucial enzyme capable of replenishing telomere length and resetting cellular lifespan. Baicalin is proven to be one of the very few natural small molecules capable of effectively activating this enzyme.

CORE MECHANISM: ACTIVATING HTERT EXPRESSION

DEFENDING AGAINST PHOTOAGING: UVA/UVB PROTECTION

MOLECULAR TARGETS: REGULATING P53/P16 SIGNALING

IN VITRO: SIGNIFICANT ROS SCAVENGING

IN VITRO: PROMOTING FIBROBLAST PROLIFERATION

IN VITRO: DNA DAMAGE REPAIR (Γ-H2AX)

Clinical Research: Efficacy Validation

CLINICAL: MULTI-DIMENSIONAL WRINKLE REDUCTION

CLINICAL: ENHANCING ELASTICITY & FIRMNESS

CLINICAL: IMPROVING TEXTURE & REFINEMENT

COMPARISON: NANOACTIVE® VS TRADITIONAL

FORMULATION GUIDELINES: STABILITY & COMPATIBILITY

SAFETY & COMPLIANCE: RIGOROUS STANDARDS

Redefining High-End Anti-Aging Actives

NanoActive® BAICALIN is more than just an antioxidant; it is a molecular bridge across the Hayflick limit. Through precise targeting of telomerase, we enable skin cells to recapture the metabolic vitality of their youth.

NanoActive DMC

Posted on 04/30/202604/30/2026 by L, Y

Advanced Delivery System by PuriPharm Co. Ltd.

Liposomal Dimethylmethoxy Chromanol. The ultimate dual-scavenger shield against Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), engineered for maximum bioavailability.

1. Redefining Antioxidant Protection

Dimethylmethoxy Chromanol is widely recognized as one of the most potent synthetic analogs of γ-tocopherol. Unlike traditional antioxidants that only target Oxygen free radicals, DMC is a unique dual-scavenger, effectively neutralizing both ROS and RNS, preventing lipid peroxidation and protein damage.

However, incorporating DMC into cosmetic formulations presents challenges due to its solubility and stability issues. PuriPharm’s NanoActive technology solves this by encapsulating DMC within nanometric liposomal vesicles. This structural mimicry of the stratum corneum ensures superior stability, profound epidermal penetration, and sustained release of the active molecule.

Key Advantages:

Dual Scavenging: Neutralizes both ROS and RNS, offering 360° cellular protection.
Liposomal Delivery: Nano-scale vesicles ensure deep penetration and prolonged efficacy.
Photo-aging Defense: Prevents UV-induced DNA damage and premature skin aging.
Formulation Friendly: Water-soluble liposomes easily integrate into aqueous phases.

2. The Science Behind the Shield

A targeted approach to cellular defense and delivery.

① ROS & RNS Quenching

Environmental stressors (pollution, UV) trigger ROS (like Superoxide) and RNS (like Peroxynitrite). DMC acts as an electron donor, rapidly stabilizing these radicals before they can initiate cascading lipid peroxidation in cell membranes.

② Phospholipid Bilayer Integration

PuriPharm encapsulates DMC in a flexible, biocompatible phospholipid bilayer. This liposome protects the fragile DMC molecule from premature oxidation within the cosmetic formula, dramatically increasing shelf-life.

③ Targeted Release

Due to their nanometric size (< 100nm) and biomimetic nature, the liposomes fuse with the stratum corneum, releasing DMC directly into the deeper epidermal layers where cellular protection is most critical.

3. Technical Specifications

Designed for cosmetic formulators seeking uncompromising quality, stability, and ease of use in advanced skincare architectures.

4. Applications

Anti-Aging Serums: Prevent structural protein degradation.
Anti-Pollution Creams: Shield against urban environmental stress.
Suncare & After-Sun: Mitigate UV-induced oxidative cascade.
Brightening Essences: Prevent oxidation-triggered melanogenesis.

NanoActive Sulfur

Posted on 04/18/202604/18/2026 by L, Y

Introduction

Sulfur is a yellow nonmetal widely distributed throughout the earth and has long been used as an effective treatment for various skin disorders. Its activity depends on the interaction between sulfur particles and keratinocytes: the smaller the particles, the larger the contact area and the better the efficacy. Bio-derived sulfur formed by the bacterial oxidation of sulfides into elemental sulfur shows better spreadability on the skin and higher activity.

NanoActive Sulfur, developed through a nano-delivery system, effectively regulates sebum secretion and helps treat acne and dandruff, while also providing strong antibacterial and anti-inflammatory activity.

Sebum Regulation

Excessive sebum secretion accumulates in follicles, enlarges pores, causes follicular blockage, and may even trigger inflammation.

NanoActive Sulfur effectively removes excess surface oil and helps soften the epidermis. It can also dissolve keratin and relieve skin imbalance caused by overactive oil secretion. In addition, it helps improve acne, pimples, and seborrheic dermatitis associated with overactive sebaceous glands.

Keratolytic Effect

Cystine is a major component of the stratum corneum. At low concentrations, sulfur promotes normal keratinization through its keratoplastic activity. At high concentrations, the same reaction produces a keratolytic effect because hydrogen sulfide disrupts keratin, and sufficient accumulation can dissolve the stratum corneum.

Therefore, NanoActive Sulfur is recommended for cosmetic formulations designed to regulate sebum secretion.

Antibacterial Action

The antibacterial action of sulfur depends on its conversion into pentathionic acid (H₂S₅O₆), a compound toxic to fungi. Hydrogen sulfide may also contribute to this activity. Through the action of skin bacteria and keratin-forming cells, sulfur can be converted into pentathionic acid. In addition, sulfur’s keratolytic activity may help separate fungi from the stratum corneum.

Therefore, NanoActive Sulfur is recommended for cosmetic formulations with purifying and preservative functions.

Pentathionic Acid Activity

Anti-inflammatory Action

Glutathione (GSH) is the most important cellular antioxidant. It exists in the reduced thiol form (GSH) and the oxidized disulfide form (GSSG), and undergoes thiol-disulfide exchange catalyzed by thiol transferases. Severe oxidative stress depletes intracellular GSH.

NanoActive Sulfur can promote GSH synthesis while reducing pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α, delivering a strong anti-inflammatory effect.

Inflammatory Factor Reduction

The protein expression levels of TNF-α, IL-1β, and IL-6 were measured by ELISA.

Compared with the control group, NanoActive Sulfur reduced the expression of TNF-α, IL-1β, and IL-6 in a dose-dependent manner.

NanoActive Sulfur in Acne Treatment

5% NanoActive Sulfur 2 months

Visible improvement in acne appearance after continuous use.

Challenges in Sulfur Applications

Advantages of NanoActive Sulfur

NanoActive Sulfur has a unique chemical structure (linear and hydrophilic), making it easier to formulate, easier to combine with other ingredients, and easier to absorb.

Nano-delivery System

NanoActive Sulfur developed with a nano-delivery system (NDS) has a particle size below 30 nm. It completely solves sulfur solubility issues by stably encapsulating sulfur inside nano-carriers, greatly improving absorption efficiency and bioavailability.