Manufacturer: PuriPharm Co. Ltd.

1. Product Overview

NanoActive MN is an advanced, high-performance bioactive ingredient engineered specifically for premium skin and hair care formulations. Utilizing state-of-the-art nano-delivery technology, NanoActive MN features a specialized lipophilic tail that drastically improves skin penetration while minimizing the irritation and sensitization traditionally associated with unmodified nicotinic acid.

Once delivered into the skin, it undergoes targeted conversion into Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme that orchestrates cellular energy metabolism, DNA repair, and lipid synthesis, fundamentally reversing the age-related decline of skin and hair follicle vitality.

2. INCI & Chemical Information

• INCI Name: Myristyl Nicotinate
• Product Type: Nano-encapsulated Bioactive Agent

3. Technology Highlights

PuriPharm Co. Ltd. leverages proprietary core technologies to ensure maximum efficacy:

• Nano Delivery System: Advanced nanotechnology ensures optimized bioavailability and targeted, deep-layer delivery of the active compound.
• Enhanced Penetration: The lipophilic modification facilitates superior transepidermal transportation.
• Targeted Action: Precisely targets local skin cells and hair follicles where esterase activity initiates the conversion process.
• Improved Stability: Formulated to protect the active core, ensuring long-term shelf-life and robust compatibility within complex cosmetic matrices.

4. Mechanism of Action: The NAD+ Pathway

NAD+ levels natively decline by up to 50% by middle age, leading to compromised cellular repair and energy metabolism.

NanoActive MN effectively addresses this:

1. Enzymatic Cleavage: Upon penetration, native skin esterases selectively cleave the lipophilic tail of NanoActive MN.
2. Conversion: The molecule is efficiently converted into the active coenzyme NAD+ via cellular synthetic pathways.
3. Cellular Optimization: The synthesized NAD+ directly fuels mitochondrial energy generation, upregulates barrier lipid synthesis, and supports genomic (DNA) repair, combating oxidative stress and cellular senescence.

5. Proven Cosmetic Benefits & Efficacy Data

NanoActive MN has demonstrated remarkable results across comprehensive clinical andin vitroevaluations:

A. Profound Skin Barrier Repair

• Visual & Structural Improvement: Clinical studies demonstrate a 250% improvement in barrier function on facial skin and an 11% improvement on the forearm volar surface (at 5% use level).
• Epidermal Fortification: Induces a highly significant 70% increase in epidermal thickness (compared to a 13% increase in the control group).
• Tight Junction Enhancement: Upregulates ZO-1 protein expression (3.38-fold relative expression at 0.04 mg/mL), physically reinforcing the skin barrier.

B. Anti-Aging & Cellular Renewal

• Accelerated Renewal: Safely accelerates skin cell renewal by reducing Dansyl turnover time and increasing Minimal Erythema Dose (MED) without inducing photosensitivity.
• Antioxidant Capacity: Exhibits excellent DPPH radical scavenging ability (6.10% maximum clearance at 0.3125%).

C. Hair Follicle Vitality & Anti-Hair Loss

• Scalp Energy: Converts to NAD+ within the scalp, enhancing cellular ATP, stimulating follicle cell renewal, and actively neutralizing oxidative stress.
• Clinical Hair Improvement: Well-designed clinical trials confirm significant improvements in hair abundance, density, hair shaft thickness, and overall hair quality with zero reported adverse effects.

D. Synergistic Efficacy with Retinoids

• Retinol Companion: When formulated alongside retinoic acid or its derivatives, NanoActive MN acts as a potent buffer—significantly reducing retinoid-induced irritation and Transepidermal Water Loss (TEWL) while amplifying overall anti-aging efficacy.

6. Formulation Guidance & Compatibility

NanoActive MN is designed for seamless integration into modern cosmetic chemistry.

• Suggested Use Level: 0.2% – 5.0%
• Suitable Formulations: O/W and W/O Emulsion systems, Creams, Lotions, Serums, Essential Oils, Massage Oils, and Cleansing products.
• Ingredient Compatibility: Exhibits excellent compatibility with a wide array of cosmetic raw materials including UV filters, emollients, humectants, natural oils, potent antioxidants, emulsifiers, thickeners, and retinoids. Minimal degradation is observed even in complex formulation matrices.

7. Recommended Applications

• Advanced Facial Care: Anti-aging creams, barrier-repair lotions, and high-potency cellular regeneration serums.
• Eye Care: Non-irritating eye creams and serums targeting fine lines and delicate skin reinforcement.
• Hair & Scalp Care: Anti-hair loss treatments, scalp energizing tonics, and hair density serums.
• Color Cosmetics: Functional lipsticks, lip glosses, eyeliners, and mascaras requiring bioactive support.

8. Storage, Stability, and Handling

• Long-Term Stability: Demonstrates exceptional stability; viable for 24 months at room temperature in various formulations. Withstands accelerated stability testing (3 months at 40°C).
• Storage Conditions: Store in a cool, dry environment between 4°C and 25°C. Protect from direct sunlight and moisture. Keep the original container tightly sealed when not in use.

Disclaimer:The information contained in this document is provided in good faith and is based on our current laboratory data and technical knowledge. It is intended for informational purposes only. Formulators are responsible for ensuring the stability, safety, and legal compliance of their final consumer products. PuriPharm Co. Ltd. makes no warranties, expressed or implied, regarding the use of this product.