P U R I P H A R M C O . , L T D .
PURIACTIVES® · NANOACTIVE™ Nanoliposome Series
NanoActive™ GalaBiome™
Nanoliposomal Prebiotic Barrier Platform
Microbiome × Hydration × Barrier
PuriPharm Co. Ltd.
PARADIGM SHIFT
Moisturization Is More Than Adding Water
Skin hydration is an ecosystem function.
Traditional moisturization focuses on humectants, occlusives, and emollients. Modern skin science shows that skin hydration is an ecosystem function created by multiple interacting factors.
SIX KEY FACTORS
Lipid architecture; natural moisturizing factor (NMF); tight junctions; water transport; the acid mantle; and the skin microbiome.
A MUTUALLY SUPPORTIVE LOOP
Healthy microbiome ↕ healthy barrier ↕ healthy hydration
The three dimensions reinforce one another. An imbalance in any one dimension can propagate through the whole system—this is the scientific basis of “ecosystem hydration.”
Reference: Lee HJ, Kim M. Skin Barrier Function and the Microbiome. Int J Mol Sci. 2022;23:13071. doi:10.3390/ijms232113071.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
MICROBIOME × BARRIER
Microbiome & Barrier: A Bidirectional Symbiotic Defense Network
DEFENSE PATHWAY
Microbial barrier → acid mantle → metabolites/innate signals → keratinocyte differentiation → tight junctions → ceramide lipid barrier
TEWL ↓ · HYDRATION ↑
Lower transepidermal water loss and improved skin hydration
Healthy commensal microorganisms help build four layers of defense:
PHYSICAL
Commensals occupy ecological niches and reinforce the integrity of surface defenses.
CHEMICAL
Metabolism produces organic acids that help maintain the acid mantle.
MICROBIAL
Competition for nutrients and adhesion sites limits the dominance of opportunistic microbes.
IMMUNE
Contributes to homeostatic regulation of innate and adaptive immune signaling.
Healthy commensals do more than simply exist on the skin surface; they actively participate in the skin’s defense network.
Reference: Lee HJ, Kim M. Skin Barrier Function and the Microbiome. Int J Mol Sci. 2022;23:13071. doi:10.3390/ijms232113071.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
PRODUCT OVERVIEW
One Platform. Four Biological Dimensions.
SELECTIVE PREBIOTIC POLYOL
Lactitol: a lactose-derived disaccharide polyol that supports a healthy skin microbiome through selective prebiotic logic—selective nourishment rather than broad-spectrum feeding.
HYDRATION & BARRIER BIOLOGY
XAX ternary sugar-derivative system: Xylitylglucoside + Anhydroxylitol + Xylitol—multi-pathway hydration biology spanning water reserves, water circulation, and barrier lipids.
BIOMIMETIC LIPID INTERFACE
Phospholipids: amphiphilic structures analogous to biological membranes, creating a biomimetic lipid interface while supporting barrier lipids.
ADVANCED DELIVERY ARCHITECTURE
NanoActive™ nanoliposomes: nanoscale phospholipid vesicles encapsulate the aqueous phase of sugar-based actives for uniform distribution, local retention, and synergistic delivery.
Biome × hydration × barrier × delivery—one platform, four biological dimensions.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
LACTITOL
Lactitol | Selective Prebiotic Logic from Sugar Science
IDENTITY
Lactitol is a lactose-derived disaccharide polyol. Its value is not limited to humectancy; it lies in the prebiotic potential created by selective fermentation.
Feed the beneficial ecosystem, rather than simply feeding everything.
SCIENTIFIC EVIDENCE
Pure-culture screening compared how broadly different candidate prebiotic substrates were used by microorganisms:
- Lactitol was used with high specificity by Lactobacillus-related strains;
- Common substrates such as galacto-oligosaccharides and fructo-oligosaccharides were used by a broader range of microorganisms;
- The study reported that this degree of selectivity had not been observed among previously established prebiotics.
This selective utilization profile makes lactitol an ideal sugar-based nutritional substrate for targeted support of beneficial microbiota.
In-vitro pure-culture evidence for lactitol’s prebiotic mechanism supports its selective nourishment rationale.
Reference: Mäkeläinen H, Saarinen M, Stowell J, Rautonen N, Ouwehand AC. Beneficial Microbes. 2010;1(2):139-148. doi:10.3920/BM2009.0029.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
SELECTIVE ECOLOGY
Lactitol + Xylitol: Selective Skin Ecology
Selective polyol ecology—not “killing microbes,” but shaping ecological selection.
ECOLOGICAL SELECTION
The polyol combination provides selectively utilized nutritional substrates.
SUPPORT HEALTHY RESIDENT MICROBIOTA
Resident commensals gain a nutritional advantage.
LIMIT OPPORTUNISTIC DOMINANCE
Helps restore a more stable skin ecosystem.
In-vitro evidence
30–50%
In-vitro inhibition of growth for selected opportunistic microorganisms by the polyol system
≈100%
Increase in growth for selected healthy resident skin microorganisms
Suppress opportunistic advantage while supporting resident commensals—this is the essential difference between ecological selection and broad-spectrum antimicrobial strategies.
Reference: WO1995015149A1. Novel Cosmetic Compositions Containing Simple Polyols. 1995.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
ACID MANTLE
Supporting the Skin’s Acidic Ecosystem
The skin’s acidic environment is both a chemical barrier and a driver of microbial selection. A cleansing-induced rise in pH temporarily disrupts this balance; a polyol ecosystem-support system can help the skin return more quickly to its physiological acidic state.
Human study: 2% lactitol + 2% xylitol system
TIMELINE
Washing → pH rises and the acid mantle is temporarily disrupted → polyol ecosystem support → faster return to physiological acidic pH
4–6 h
Typical time required for the cleansing-induced pH rise to return to baseline
≈3 h
Recovery time after use of the polyol system (p < 0.05), with a more favorable microbial composition also observed
Reference: WO1995015149A1. Novel Cosmetic Compositions Containing Simple Polyols. 1995.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
XAX SYSTEM
XAX | From Humectancy to Hydration Biology
XAX = Xylitylglucoside + Anhydroxylitol + Xylitol. It is not an ordinary sugar-based humectant, but a hydration system acting simultaneously on three biological axes:
AXIS 01 · WATER RESERVOIR
Enhances water-reserve systems such as hyaluronic acid and chondroitin sulfate, building an internal skin “reservoir.”
AXIS 02 · BARRIER LIPIDS
Promotes ceramide-related synthesis and optimization of the lipid barrier, reducing water loss at its source.
AXIS 03 · WATER CIRCULATION
Modulates mechanisms related to tight junctions and epidermal water transport, enabling orderly movement of water through the skin.
Reservoir + lipids + circulation: from “holding water” to “managing water”—XAX forms the biological hydration backbone of GalaBiome™.
Reference: Garcia C, et al. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
CERAMIDE BIOLOGY
Reshaping the Lipid Logic of the Stratum Corneum
BRICK & MORTAR MODEL
Corneocytes are the “bricks,” while intercellular lipids such as ceramides form the “mortar.”
MECHANISM
XAX → de novo ceramide synthesis ↑ + cholesterol synthesis pathway (HMGCR-related) ↑ → more orderly intercellular lipid matrix → barrier strength ↑ → TEWL ↓
In-vitro evidence · De novo ceramide synthesis
Human skin explant model: 3% XAX versus untreated control (P < 0.05); differences for placebo and glycerol were not statistically significant (ns). Barrier improvement consistent with reduced TEWL was also observed.
Reference: Garcia C, Valin E, Hernandez E, Kern C, Roso A. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
WATER RESERVOIR
Building an Internal Water Reservoir in the Skin
MECHANISM
XAX → acts on fibroblasts and keratinocytes → hyaluronic acid (HA) ↑ + chondroitin sulfate (CS) ↑ → extracellular-matrix water-binding capacity ↑ → expansion of the skin’s internal water reservoir
Hyaluronic acid and chondroitin sulfate are core glycosaminoglycans in dermal–epidermal water reserves and determine the skin’s water-storage capacity.
Cell model · Dose-dependent stimulation of chondroitin sulfate synthesis
In-vitro cultured human skin fibroblasts; mechanistic cell-model data. Differences in the two higher-concentration groups were statistically significant (P < 0.05). XAX also increased hyaluronic acid production in the cell model.
Reference: Garcia C, Valin E, Hernandez E, Kern C, Roso A. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
WATER CIRCULATION
Hydration Is a Dynamic Flow
Hydration is not simply the static act of “holding water.”
HYDRATION FLOW
Reservoir → transport → retention → controlled loss
WATER FLOW PATHWAY
Dermis → epidermis · tight junctions → stratum corneum
XAX-REGULATED GENES
CGN (cingulin); CLDN-4/CLDN-5/CLDN-7 (claudins); and multiple genes related to epidermal differentiation, keratinization, and tight junctions.
Evidence derives from a gene-expression study in a 3D reconstructed epidermis model.
Water reservoir + water circulation + barrier retention—this is the scientific narrative that differentiates GalaBiome™ from a simple humectant.
Reference: Garcia C, Valin E, Hernandez E, Kern C, Roso A. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
HUMAN EVIDENCE
Long-Lasting Hydration Beyond the Moment of Application
Human study: 25 female volunteers with dry skin used 3% XAX for 30 days. Benefits progressed over time, moving from immediate hydration toward structural improvement.
8 HOURS
Corneometry +6% and TEWL −8%—an immediately visible hydration response.
DAY 15
Hydration benefits remained stable while barrier indicators continued to improve.
DAY 30
Corneometry +11% and TEWL −15%—a transition from water replenishment to barrier-structure improvement.
Corneometry reflects stratum-corneum hydration, while TEWL was measured by evaporimetry. The same study also observed approximately 33% improvement in skin micro-roughness and approximately 25% improvement in desquamation.
Human research on XAX validates its multi-pathway hydration and barrier mechanisms—GalaBiome™ integrates them into a unified ecosystem platform.
Reference: Garcia C, Valin E, Hernandez E, Kern C, Roso A. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
RAMAN SCIENCE
Not All Water in the Stratum Corneum Is the Same
GLOBAL WATER
Overall hydration level of the stratum corneum.
PARTIALLY BOUND WATER
Water weakly associated with stratum-corneum structures.
UNBOUND WATER
Freely mobile water molecules.
KEY RAMAN FINDINGS — SUGAR-DERIVED COMPLEX
- All three water states improved: global, partially bound, and unbound water
- Water-retention capacity increased
- Lateral organization of stratum-corneum lipids became more orderly
- Keratin structural stability improved
- Effects were observed not only at the surface but also at a depth of 8 μm
CONFOCAL RAMAN DEPTH PROFILE
Surface: all three water states improved.
At 8 μm in the stratum corneum: improvement was also observed—benefits were not limited to the surface.
Reference: Fluhr JW, Tfayli A, Darlenski R, et al. J Biophotonics. 2023;16:e202200201. doi:10.1002/jbio.202200201.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
NANOLIPOSOME
From Prebiotic Molecules to a Biomimetic Delivery Interface
NANOLIPOSOME STRUCTURE
Aqueous core: an active aqueous pool of lactitol + XAX.
Phospholipid bilayer: surrounds the aqueous core.
External water phase: vesicles are dispersed in the continuous aqueous phase.
WHAT THE SYSTEM PROVIDES
- A reservoir for aqueous actives
- A phospholipid-bilayer interface
- More uniform distribution across the skin/scalp surface
- Synergy with a biomembrane-like lipid environment
- Improved delivery performance and user experience
- A dual microbiome + barrier platform
The phospholipid bilayer has an amphiphilic structure similar to biological membranes—this delivery architecture differentiates GalaBiome™ from an ordinary blended solution.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
DELIVERY DIRECTION
A Scientifically Established Delivery Direction
CARRIER DIRECTIONS ESTABLISHED IN PUBLIC PATENTS
Polyols such as lactitol and xylitol may be delivered in cosmetics as liposomes, micro/nanoparticles, or micro/nanocapsules.
MORE RECENT EXTENSIONS
Public patent research has also explored topical delivery of microbiome-related actives using phospholipid liposomes. Liposomes × microbiome care is a scientifically validated technical direction.
PATENT REFERENCES
WO1995015149A1 (1995) | Novel Cosmetic Compositions Containing Simple Polyols.
US20240216265A1 (2024) | Liposomal Vegan Probiotic Skin Treatment.
GalaBiome™’s polyol × liposome architecture is built on decades of publicly available scientific development.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
16 · INTEGRATED MECHANISM
The GalaBiome™ 4D Mechanism
NanoActive™ GalaBiome™
Balanced microbiome × optimized hydration × stronger barrier × improved skin & scalp comfort
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
POSITIVE FEEDBACK
Microbiome–Ceramide Crosstalk
FORWARD
Healthy microbiome → metabolic activity of commensals such as S. epidermidis → sphingomyelinase participates in host ceramide formation → ceramide homeostasis → barrier integrity + water retention ↑
REVERSE
A healthy, stable barrier with appropriate pH → dense lipid matrix and intact acid mantle → more secure commensal niches → a more stable microbiome
Positive Microbiome–Barrier Loop
Frontier science from skin-microbiome reviews indicates that healthy commensals participate in barrier-lipid homeostasis through metabolic activity. This is the theoretical foundation of GalaBiome™’s integrated microbiome × barrier design.
Reference: Lee HJ, Kim M. Skin Barrier Function and the Microbiome. Int J Mol Sci. 2022;23:13071. doi:10.3390/ijms232113071.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
18 · SCALP ECOSYSTEM
The Scalp Is Skin — With a Different Ecosystem
High sebum × abundant follicles: a distinctive microenvironment.
High microbial density: a more sensitive microbial balance.
Barrier readily affected by cleansing and the environment: more fragile water and lipid homeostasis.
Blow-drying/coloring/perming: thermal and chemical stress.
Environmental stress: dryness, pollution, and UV exposure.
Scalp care cannot focus only on dandruff removal or oil control; three dimensions must be managed together:
Scalp microbiome × scalp barrier × scalp hydration
GalaBiome™ = Scalp Ecosystem Conditioner
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
SCALP EVIDENCE
Scalp Hydration & Barrier Support
Human scalp study of a lactitol/xylitol system
28 volunteers (16 women + 12 men) · 10-day regimen · used in shampoo, conditioner, and leave-on scalp care.
+27%
Immediate moisturization: increase in scalp hydration immediately after application
+17%
Long-lasting moisturization: sustained scalp hydration
BARRIER & DESQUAMATION
TEWL results supported improved scalp-barrier integrity; videomicroscopy showed improvement in the appearance of scalp desquamation.
From hydration to barrier support, and from immediate to lasting benefits, the polyol ecosystem concept also applies to the scalp—providing human evidence for GalaBiome™ scalp applications.
Reference: Human scalp claim substantiation study, 28 volunteers, 10-day regimen, Dec. 2004. · WO2006061678A1. Cosmetic or Dermatological Compositions of Saccharose Substitutes.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
APPLICATIONS
One Biological Platform. Multiple Beauty Applications.
SKIN
- Barrier-repair serum
- Hydrating serum
- Cream for sensitive skin
- Microbiome-supporting moisturizing lotion
- Gel cream/sheet mask
- Gentle cleansing/post-cleansing care
SCALP & HAIR
- Scalp essence/scalp treatment
- Shampoo/conditioner
- Hair mask
- Leave-on scalp treatment
- Anti-dryness scalp care
- Sensitive-scalp care
Healthy scalp → a better environment for hair. Scalp hydration, comfort, and barrier support—combined with the emollient sensory profile and hair-care compatibility of phospholipids—make a healthy scalp the best environment for beautiful hair.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
FOR FORMULATORS
Designed for Modern Formulation Thinking
A single humectant mainly addresses immediate water attraction; a single prebiotic mainly supports a microbiome concept; traditional barrier lipids mainly provide lipid replenishment. GalaBiome™ integrates prebiotic support + hydration biology + barrier support + nanoliposomes into one platform.
| Technical dimension | Humectant | Single prebiotic | GalaBiome™ |
| Immediate hydration | ✓ | — | ✓ |
| Biological hydration | — | — | ✓ |
| Microbiome support | — | ✓ | ✓ |
| Barrier support | Limited | Indirect | ✓ |
| Nanoliposomal delivery | — | — | ✓ |
| Skin + scalp | Limited | Possible | ✓ |
One addition covers four core dimensions of modern formulation.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
CLAIM ARCHITECTURE
Claim Architecture
MICROBIOME
- Supports skin ecosystem balance
- Helps maintain microbiome homeostasis
- Prebiotic skin and scalp care
HYDRATION
- Immediate and long-lasting moisturization
- Supports skin water reserves
- Optimizes water-retention capacity
BARRIER
- Helps strengthen the moisture barrier
- Supports ceramide and lipid homeostasis
- Helps reduce excessive water loss
SCALP
- Supports scalp hydration
- Improves scalp comfort
- Helps maintain scalp ecosystem balance
- Supports a healthy-looking scalp
TECHNOLOGY
- Nanoliposomal prebiotic platform
- Biomimetic phospholipid delivery
- Microbiome–barrier synergy
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
PRODUCT CONCEPTS
From Ingredient to Product Concepts
MICROBIOME BARRIER SERUM
Prebiotic ecosystem support; ceramide biology; long-lasting hydration.
SKIN ECOSYSTEM CREAM
Barrier strengthening; comfortable skin feel; suitable for dry and sensitive skin.
SCALP BIOME ESSENCE
Scalp hydration; improved appearance of flaking; scalp comfort.
HYDRATING BIOME SHAMPOO
Gentle cleansing; scalp-ecosystem friendly; post-wash comfort.
Four premium concept directions—from face to scalp, multiple expressions of the same platform.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.
24 · SUMMARY
NanoActive™ GalaBiome™
Microbiome × Hydration × Barrier × Nanoliposome
A Smarter Ecosystem for Skin & Scalp.
PuriPharm Co. Ltd.
REFERENCES
Scientific References
JOURNALS
- Lee HJ, Kim M. Skin Barrier Function and the Microbiome. Int J Mol Sci. 2022;23:13071. doi:10.3390/ijms232113071.
- Garcia C, Valin E, Hernandez E, Kern C, Roso A. Effect of a Simple Sugar-based Ingredient on Skin Moisturization: Biological Mode of Action and Clinical Effects. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.
- Fluhr JW, Tfayli A, Darlenski R, et al. Glycerol and natural sugar-derived complex modulate differentially stratum corneum water-binding properties and structural parameters in an in vitro Raman-desorption model. J Biophotonics. 2023;16:e202200201. doi:10.1002/jbio.202200201.
- Mäkeläinen H, Saarinen M, Stowell J, Rautonen N, Ouwehand AC. Xylo-oligosaccharides and lactitol promote the growth of Bifidobacterium lactis and Lactobacillus species in pure cultures. Beneficial Microbes. 2010;1(2):139-148. doi:10.3920/BM2009.0029.
PATENTS
- WO1995015149A1 (1995) | Novel Cosmetic Compositions Containing Simple Polyols.
- WO2006061678A1 (2006) | Cosmetic or Dermatological Compositions of Saccharose Substitutes.
- US20240216265A1 (2024) | Liposomal Vegan Probiotic Skin Treatment.
- WO2026167254A1 (2026) | Compositions Comprising Alditol and Alditol Derivatives for Supporting and Protecting the Skin.
NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.