NanoActive r-RETINOATE
8× retinol activity
Photostable • Non-irritating
A next-generation vitamin A derivative
Company Overview
PuriPharm Biopharmaceutical Technology Co., Ltd.
Delivering Beauty • Creating Value
Focused on the research and development of bioactives.
- Specialized in the development of bioactive materials and functional ingredient systems.
- Combines scientific delivery technology with application-oriented product design.
- Dedicated to high-performance ingredients for beauty and personal care.
Nano Delivery Technology
- One of the most widely studied and applied new formulation technologies.
- Applicable across pharmaceuticals, foods, cosmetics and other fields.
- Nano-bioactives are new products developed using nanodelivery systems.
- Improves solubility, stability, irritation profile and odor while offering unique biological effects.
Fourth-Generation (4G) Cosmetic Ingredients
- Clearly defined ingredients and content
- Clearly defined targets
- Clear mechanism of action
- Formulations designed to preserve bioactivity
- Good solubility
- Stable and non-discoloring
- Easy to absorb
A perfect combination of traditional medicine, modern biotechnology and nanotechnology.
Unique Occlusion Effect
Follicular Targeted Absorption
- Nanocarriers accumulate efficiently around the hair follicle pathway.
- This supports targeted delivery into deep skin appendages where actives can be retained and released.
Key takeaway：Hair follicles provide an efficient access route for targeted nano-delivery.
Smaller Particles Penetrate Deeper
and in Greater Amounts
- Reduced particle size increases penetration depth in skin.
- Smaller particles also increase the delivered amount of active ingredient.
The smaller the carrier, the deeper the penetration and the higher the delivery amount.
Follicular Reservoir Enables Slow Release for
More Than 10 Days
- Hair follicles act as a storage reservoir for the active ingredient.
- The active can be released gradually for more than 10 days after deposition.
- This supports long-lasting efficacy with sustained local availability.
Long-lasting delivery：Slow release extends the activity window after follicular deposition.
Vitamin A：
A core scientific foundation for the product story
Functions of Vitamin A in the Human Body
- Supports vision and visual signaling.
- Contributes to growth, reproduction and immune support.
- Involved in antioxidant defense, cell differentiation and gene transcription.
Vitamin A and Nobel Prizes
Vitamin A Is the Gold Standard in Anti-Aging Skincare
Common Vitamin A Actives Used in Skincare
Conversion to Retinoic Acid in Vivo
Why It Won the Award
2019 Ringier Technology Innovation Award
- Vitamin A derivative suitable for daytime use
- Safe and low irritation
- Nano-encapsulation protects the active ingredient
- A breakthrough and a new technical approach for retinoid raw materials
A distinctive retinoid concept that balances efficacy, stability and tolerability.
Unique Absorption Spectrum
- Distinctive absorption profile
- Efficient blue-light absorption
- Good photostability
Product Introduction
- Retinyl retinoate is obtained by esterifying the hydroxyl group of retinol with retinoic acid, while avoiding the application limits of retinol and retinoic acid in cosmetics.
- NanoActive r-RETINOATE has an encapsulated particle size of 20–30 nm. This nanoemulsion size keeps the active stably suspended in the nanocarrier, enhances skin penetration and helps control the release rate.
Particle size：20–30 nm nano-encapsulation；
Delivery effect：Stable suspension, enhanced penetration and controlled release
Product Introduction
Skincare Benefits of Retinyl Retinoate
Efficacy Summary
Product Description
Formulation Guide
Suitable Products
Anti-aging products：
Maintains collagen in the dermis and helps prevent excessive collagen degradation.
When combined with hyaluronic acid and biocomposite polysaccharides (hydrolyzed myrtle), improvement in fine lines can be observed within one week.
Brightening products：
Works synergistically with vitamin C to inhibit tyrosinase, promote metabolism and accelerate fading of melanin.
The source deck notes that pairing with vitamin C is also effective for acne-prone skin.
Suitable Products
Sunscreen products：
Inhibits the UV-induced increase of MMP activity and helps protect elastic fibers and dermal collagen.
Improves wrinkles and fine lines caused by UV exposure.
Repair products：
Promotes endogenous hyaluronic acid synthesis and reduces skin TEWL.
Promotes keratinocyte activity and increases epidermal thickness, making the epidermis stronger.
